Transcranial magnetic sham stimulation equipment and related products

Abstract

The present application provides a transcranial magnetic sham stimulation device and related products. When a subject is subjected to transcranial magnetic sham stimulation, the current detection module of the device detects the magnitude of the stimulation current output by the stimulation generating device; the current attenuator attenuates the stimulation current to obtain an attenuated current; the current converter converts the attenuated current to provide a power supply current for a waveform modulator; the waveform modulator provides a first input current to a sham stimulation response module on the stimulation coil based on the magnitude of the stimulation current and the power supply current, so that the first response generated by the sham stimulation response module is the same as the second response generated by the stimulation coil when the subject is subjected to real transcranial magnetic stimulation using the stimulation current. The present application is conducive to improving the authenticity of transcranial magnetic sham stimulation and reducing the impact of the subject's psychological effects on the experimental results.

Description

Technical Field

[0001] The present application relates to the field of biomedical engineering, and in particular to a transcranial magnetic sham stimulation device and related products. Background Art

[0002] With the development of science and technology, transcranial magnetic stimulation (TMS) is increasingly used in the field of neurological diseases and rehabilitation treatment. During transcranial magnetic stimulation, a stimulation current of corresponding frequency and intensity can be output through a stimulation generator. The stimulation current flows through the coil loop of the stimulation coil to form a magnetic field. The generated magnetic field can act on the subject's brain central nervous system to affect the subject's brain metabolism and neural electrical activity, achieving a therapeutic effect.

[0003] When studying the therapeutic effect of transcranial magnetic stimulation on diseases, it is impossible to accurately judge whether the therapeutic effect of the disease is related to transcranial magnetic stimulation due to the influence of the subject's psychological effects on the treatment of the disease. Therefore, it is necessary to conduct a control experiment of real transcranial magnetic stimulation and fake transcranial magnetic stimulation on the subjects to eliminate the influence of the subject's psychological effects on the treatment effect.

[0004] In existing transcranial magnetic stimulation experiments, the stimulation coil is replaced with a sham stimulation coil without a coil loop, and a control experiment of real and fake stimulation is conducted on the subjects. This results in lower authenticity of the sham transcranial magnetic stimulation and still a greater impact on the subjects' psychological effects. Summary of the invention

[0005] In order to solve the above-mentioned problems existing in the prior art, the embodiments of the present application provide a transcranial magnetic sham stimulation device and related products, which attenuates the stimulation current output by the stimulation generating device and then returns it to the stimulation generating device, and based on the detected size of the stimulation current, provides a first input current to the sham stimulation response module, so that the sham stimulation response module produces the same response as the real transcranial magnetic stimulation, thereby improving the authenticity of the transcranial magnetic sham stimulation and reducing the impact of the psychological effects on the subjects.

[0006] In a first aspect, an embodiment of the present application provides a transcranial magnetic sham stimulation device, the transcranial magnetic sham stimulation device comprising: a transcranial magnetic stimulation control device, a stimulation generating device and a stimulation coil; the stimulation coil is provided with a sham stimulation response module;

[0007] The transcranial magnetic stimulation control device comprises: a current detection module, a current attenuator, a current converter and a waveform modulator;

[0008] When the subject is subjected to sham transcranial magnetic stimulation, the current detection module is used to detect the magnitude of the stimulation current output by the stimulation generating device;

[0009] The current attenuator is used to attenuate the stimulation current to obtain an attenuated current;

[0010] The current converter is used to convert the attenuation current to provide a power supply current for the waveform modulator;

[0011] The waveform modulator is used to provide a first input current to the sham stimulation response module on the stimulation coil based on the magnitude of the stimulation current and the power supply current, so that the first response generated by the sham stimulation response module is the same as the second response generated by the stimulation coil when the subject is subjected to real transcranial magnetic stimulation using the stimulation current.

[0012] In a second aspect, an embodiment of the present application provides a transcranial magnetic sham stimulation response method, the method is applied to a transcranial magnetic sham stimulation device, the transcranial magnetic sham stimulation device comprises: a transcranial magnetic stimulation control device, a stimulation generating device and a stimulation coil; the stimulation coil is provided with a sham stimulation response module;

[0013] The transcranial magnetic stimulation control device comprises: a current detection module, a current attenuator, a current converter and a waveform modulator;

[0014] The method comprises:

[0015] When performing sham transcranial magnetic stimulation on the subject, detecting the magnitude of the stimulation current output by the stimulation generating device;

[0016] Attenuating the stimulation current to obtain an attenuated current;

[0017] converting the attenuation current to provide a supply current for the waveform modulator;

[0018] Based on the magnitude of the stimulation current and the power supply current, a first input current is provided to the sham stimulation response module on the stimulation coil so that the first response generated by the sham stimulation response module is the same as the second response generated by the stimulation coil when the subject is subjected to real transcranial magnetic stimulation using the stimulation current.

[0019] In a third aspect, an embodiment of the present application provides an electronic device, comprising: a processor and a memory, the processor being connected to the memory, the memory being used to store a computer program, and the processor being used to execute the computer program stored in the memory, so that the electronic device executes the method described in the second aspect.

[0020] In a fourth aspect, an embodiment of the present application provides a computer-readable storage medium, wherein the computer-readable storage medium stores a computer program, and the computer program enables a computer to execute the method described in the second aspect.

[0021] In a fifth aspect, an embodiment of the present application provides a computer program product, which includes a non-transitory computer-readable storage medium storing a computer program, and the computer program is operable to cause a computer to execute the method described in the second aspect.

[0022] Implementing the embodiments of the present application has the following beneficial effects:

[0023] In the embodiment of the present application, when a subject is subjected to transcranial magnetic sham stimulation, the magnitude of the stimulation current output by the stimulation generating device is detected by the current detection module, and then the stimulation current is attenuated by the current attenuator to obtain an attenuated current, and the attenuated current is converted by the current converter to provide a power supply current for the waveform modulator. Then, the waveform modulator provides a first input current to the sham stimulation response module on the stimulation coil based on the magnitude of the stimulation current and the power supply current, so that the first response generated by the sham stimulation response module is the same as the second response generated by the stimulation coil when the subject is subjected to transcranial magnetic real stimulation using the stimulation current. Thus, the transcranial magnetic sham stimulation device can, based on the magnitude of the stimulation current, cause the sham stimulation response module on the stimulation coil to generate the same response as the transcranial magnetic real stimulation using the stimulation current, so that the subject experiences the same sensory stimulation as the transcranial magnetic real stimulation, thereby improving the authenticity of the transcranial magnetic sham stimulation and reducing the influence of the subject's psychological effects on the experimental results when conducting a control experiment. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings required for use in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0025] Figure 1 A schematic diagram of an application scenario of a transcranial magnetic pseudo-stimulation response method provided in an embodiment of the present application;

[0026] Figure 2 A schematic diagram of a transcranial magnetic sham stimulation device provided in an embodiment of the present application;

[0027] Figure 3 A schematic diagram of the structure of a fake stimulus response module provided in an embodiment of the present application;

[0028] Figure 4 A schematic diagram of another transcranial magnetic sham stimulation device provided in an embodiment of the present application;

[0029] Figure 5 A schematic diagram of a transcranial magnetic false stimulation response method provided in an embodiment of the present application;

[0030] Figure 6 A schematic diagram of the structure of an electronic device provided in an embodiment of the present application. DETAILED DESCRIPTION

[0031] The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0032] The terms "first", "second", "third" and "fourth" etc. in the specification and claims of the present application and the drawings are used to distinguish different objects, rather than to describe a specific order. In addition, the terms "including" and "having" and any variations thereof are intended to cover non-exclusive inclusions. For example, a process, method, system, product or device that includes a series of steps or units is not limited to the listed steps or units, but optionally includes steps or units that are not listed, or optionally includes other steps or units inherent to these processes, methods, products or devices.

[0033] Reference to "embodiments" herein means that a particular feature, result, or characteristic described in conjunction with the embodiments may be included in at least one embodiment of the present application. The appearance of the phrase in various locations in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0034] First, see Figure 1 , Figure 1 A schematic diagram of an application scenario of a transcranial magnetic sham stimulation response method provided in an embodiment of the present application. The transcranial magnetic sham stimulation response method is mainly used to study the therapeutic effect of transcranial magnetic stimulation on the subject's disease, and to perform transcranial magnetic sham stimulation on the subject, so as to use the experimental results of transcranial magnetic sham stimulation as the control group of the experimental results of transcranial magnetic real stimulation, thereby eliminating the influence of the patient's psychological effects on the experimental results.

[0035] It should be noted that when transcranial magnetic stimulation is performed on a subject, the stimulation generating device 110 outputs a stimulation current corresponding to the current intensity based on the current intensity set by the user, and the stimulation current flows into the stimulation coil 120 through the wire. Among them, the stimulation coil 120 includes a coil loop. When the stimulation current flows through the coil loop of the stimulation coil 120, a magnetic field corresponding to the stimulation current is formed in the coil loop, and the formed magnetic field acts on the central nervous system of the subject's brain to affect the metabolism and neural electrical activity in the subject's brain. Based on the subject's brain disease, the current intensity output by the stimulation generating device 110 is adjusted to achieve the treatment of the subject's brain disease.

[0036] in, Figure 1 The transcranial magnetic stimulation control device 100 may be a trigger switch for transcranial magnetic stimulation, and the trigger switch may trigger the stimulation generating device 110 to output a stimulation current to perform transcranial magnetic stimulation.

[0037] It should be noted that when the stimulation current flows through the coil loop to form a magnetic field, the stimulation coil 120 will vibrate due to the change in magnetic field energy, wherein the parameters such as the vibration intensity and vibration frequency of the stimulation coil 120 are related to the strength of the formed magnetic field, and thus, the parameters such as the vibration intensity and vibration frequency of the stimulation coil 120 are related to the magnitude of the stimulation current output by the stimulation generating device 110. In addition, the change in magnetic field energy will generate sound in the stimulation coil 120, for example, periodic continuous audio will be generated. When the formed magnetic field acts on the subject's brain, a regular electrical stimulation current will be formed in the subject's head. Optionally, the electrical stimulation current can be a periodic pulse current, and the formed electrical stimulation current periodically stimulates the subject's head.

[0038] Among them, since the psychological effects of the subjects will affect the therapeutic effect of the disease, in order to study the therapeutic effect of transcranial magnetic stimulation on the disease, it is necessary to set up a control group for the transcranial magnetic stimulation experiment, that is, to set up a transcranial magnetic sham stimulation group as the control group of the transcranial magnetic real stimulation group. When the experimental results of the transcranial magnetic real stimulation group are better than those of the transcranial magnetic sham stimulation group, it can be considered that transcranial magnetic stimulation is beneficial to the treatment of the disease.

[0039] At present, when conducting a control experiment of transcranial magnetic sham stimulation, the stimulation coil 120 is replaced with a sham stimulation coil that does not contain a coil loop inside, and the sham stimulation coil is placed on the subject's head. Since the sham stimulation coil does not contain a coil loop inside, the stimulation current cannot form a magnetic field in the sham stimulation coil, that is, the subject cannot be subjected to transcranial magnetic stimulation. The experimental results at this time can be used as a control group for transcranial magnetic true stimulation. However, since the coil will generate corresponding vibrations, sounds, and electrical stimulation currents when performing true transcranial magnetic stimulation, the subject cannot perceive the corresponding vibrations, sounds, and electrical stimulation currents when undergoing transcranial magnetic sham stimulation through the above-mentioned sham stimulation coil, and the psychological effects generated will still affect the experimental results. To this end, an embodiment of the present application provides a transcranial magnetic sham stimulation device, which can cause the coil to generate corresponding vibrations, sounds, and electrical stimulation currents to reduce the impact of the subject's psychological effects.

[0040] For example, see Figure 2 , Figure 2 A schematic diagram of a transcranial magnetic sham stimulation device provided in an embodiment of the present application. Figure 2 As shown, the transcranial magnetic sham stimulation device 200 comprises: a transcranial magnetic stimulation control device 100, a stimulation generating device 110 and a stimulation coil 120. The stimulation coil 120 is provided with a sham stimulation response module 121.

[0041] The transcranial magnetic stimulation control device 100 includes: a current detection module 101 , a current attenuator 102 , a current converter 103 and a waveform modulator 104 .

[0042] In the embodiment of the present application, the first end of the current detection module 101 is connected to the positive output end of the stimulation generating device 110, the second end of the current detection module 101 is connected to the input end of the current attenuator 102, and the third end of the current detection module 101 is connected to the input end of the waveform modulator 104. The first end of the current converter 103 is connected to the output end of the current attenuator 102, the second end of the current converter 103 is connected to the negative output end of the stimulation generating device 110, and the third end of the current converter 103 is connected to the power supply end of the waveform modulator 104. The output end of the waveform modulator 104 is connected to the input end of the fake stimulation response module 121 on the stimulation coil 120.

[0043] Exemplarily, when a subject is subjected to sham transcranial magnetic stimulation, the current detection module 101 detects the magnitude of the stimulation current output by the stimulation generating device 110. Specifically, the stimulation current output by the stimulation generating device 110 flows through the current detection module 101, and the current detection module 101 can detect the magnitude of the stimulation current to determine the current intensity of the stimulation current output by the stimulation generating device 110. Optionally, the current intensity can be the ratio of the stimulation current to the maximum output current of the stimulation generating device 110. For example, the ratio of the magnitude of the stimulation current output by the stimulation generating device at a current intensity of 50% to the magnitude of the maximum output current is 50%.

[0044] Optionally, the current detection module 101 may obtain a waveform corresponding to the stimulation current of the stimulation generating device 110. Based on the waveform corresponding to the stimulation current and the waveform corresponding to the maximum output current, a scaling ratio of the stimulation current is determined, that is, a ratio of the waveform corresponding to the maximum output current to the waveform corresponding to the stimulation current is determined. The scaling ratio of the stimulation current is used as the current intensity of the stimulation current.

[0045] It should be noted that the waveforms of the stimulation current commonly used by the stimulation generating device 110 are single-phase waves and biphasic waves. Among them, the single-phase wave is a pulse waveform that rises rapidly to a peak value in a damped cosine shape and then slowly decreases and has a long tail, and the biphasic wave is a sinusoidal pulse waveform of one cycle. Among them, the waveform of the stimulation current output by the stimulation generating device 110 also includes: multi-phase waves, triangular waves, rectangular waves, and other waveforms. When the waveform of the stimulation current is a rectangular wave, the current detection module 101 detects the magnitude of the stimulation current. When the waveform of the stimulation current is a waveform other than a rectangular wave, the current detection module 101 detects the waveform of the stimulation current. The embodiment of the present application only takes the current detection module 101 detecting the magnitude of the stimulation current as an example for explanation. The way in which the current detection module 101 detects the waveform of the stimulation current is similar to the embodiment of the present application, and will not be repeated here.

[0046] Then, the current detection module 101 sends the detected magnitude of the stimulation current to the waveform modulator 104, and the waveform modulator 104 can provide input current to the false stimulation response module 121 of the stimulation coil 120 based on the magnitude of the stimulation current. In addition, after flowing through the current detection module 101, the stimulation current will enter the current attenuator 102.

[0047] Exemplarily, after the current detection module 101 detects the magnitude of the stimulation current output by the stimulation generating device 110, the current attenuator 102 attenuates the stimulation current to obtain an attenuated current. Specifically, the current attenuator 102 includes a high-resistance resistor. When the stimulation current flows through the resistor of the current attenuator 102, the electrical energy is gradually converted into thermal energy, and the resistor continues to generate heat. In the process of converting electrical energy into thermal energy and releasing it into the air, the stimulation current continues to attenuate, and finally flows out from the output end of the current attenuator 102 to obtain an attenuated current.

[0048] Optionally, the current attenuator 102 can be, for example, a T-type current attenuator or a π-type current attenuator. The T-type current attenuator is formed by three resistors connected in series, and its shape is similar to the letter T. The resistance values ​​of the resistors on the two series paths of the T-type current attenuator are equal, and the other resistor is grounded. The π-type current attenuator is also formed by three resistors connected in series, and its shape is similar to the letter π. A resistor is connected to the series path of the π-type current attenuator, and the other two resistors are grounded for shunting, and the resistance values ​​of the two grounded resistors are equal. Optionally, the current attenuator 102 can also be a bridged T-type current attenuator, which is not limited here.

[0049] It should be noted that when a stimulation current is used to perform true transcranial magnetic stimulation on a subject, a magnetic field is generated when the stimulation current flows through the coil loop in the stimulation coil 120, and the stimulation current will also decay in the process of converting electrical energy into magnetic field energy. For this reason, when a subject is subjected to false transcranial magnetic stimulation, the stimulation current is attenuated by the current attenuator 102 to simulate the current attenuation during true transcranial magnetic stimulation. The attenuation amount of the stimulation current by the current attenuator 102 is equal to the attenuation amount of the stimulation current in the coil loop when the stimulation current is used to perform true transcranial magnetic stimulation on the subject.

[0050] Exemplarily, the obtained attenuated current enters the current converter 103 , and the current converter 103 converts the attenuated current to provide a supply current for the waveform modulator 104 .

[0051] In the embodiment of the present application, the current converter 103 includes an energy storage element inside, which is used to store the electric energy of the decaying current and release the electric energy. After the current is divided, a part of the current provides the power supply current for the waveform modulator 104, and the other part of the current flows back to the stimulation generating device 110. Optionally, the energy storage element may include an inductor and a capacitor, wherein the inductor, in addition to storing electric energy, also isolates the interference of the alternating current in the circuit, and the capacitor, in addition to storing electric energy, also filters the decaying current and removes the high-frequency interference part in the decaying current.

[0052] Specifically, when converting the decaying current, the current converter 103 stores the electric energy of the decaying current; releases the electric energy, and obtains the steady-state current after filtering the released current; and shunts the steady-state current to obtain the power supply current and the return current of the stimulation generating device. Among them, the current converter 103 can be, for example, a steady-state current converter, which can filter out high-frequency interference and alternating current in the decaying current, thereby obtaining a steady-state current with a fixed current value. When the decaying current flows through the energy storage element of the current converter 103, the electric energy is gradually stored in the energy storage element. The stored electric energy is released and filtered through the energy storage element, and a steady-state current is obtained in the process of charging and discharging the energy storage element. After the steady-state current is shunted through the branch, the power supply current and the return current are obtained. The power supply current is used to power the waveform modulator 104, and the return current flows back to the stimulation generating device 110 through the wire.

[0053] First, it is explained that since the stimulation generating device 110 only supports the input and output of steady-state current, and when the subject is subjected to true transcranial magnetic stimulation, the current after the stimulation current flows through the coil loop of the stimulation coil 120 will flow back to the stimulation generating device 110 along the wire, and the current after the stimulation current flows through the coil loop of the stimulation coil 120 is a steady-state current. Therefore, when the subject is subjected to false transcranial magnetic stimulation, it is necessary to first perform a steady-state conversion on the decaying current to obtain a steady-state current, and shunt the return current from the steady-state current to flow back to the stimulation generating device 110.

[0054] It should be noted that, since the current value of the stimulation current output by the stimulation generating device 110 is relatively large, the current value of the attenuated current after the stimulation current is attenuated by the current attenuator 102 is still relatively large. Therefore, the steady-state current obtained by the current converter 103 after converting the attenuated current is sufficient to provide the power supply current for the waveform modulator 104, and a small portion of the steady-state current needs to be diverted as the power supply current for the waveform modulator 104.

[0055] Among them, the magnitude of the return current should be equal to the magnitude of the current flowing back to the stimulation generating device 110 when the subject is subjected to transcranial magnetic stimulation using the stimulation current. Therefore, based on the magnitude of the current flowing back to the stimulation generating device 110 when the subject is subjected to transcranial magnetic stimulation using the stimulation current, the current attenuator 102 and the current converter 103 can be designed so that the magnitude of the obtained steady-state current is equal to the magnitude of the current flowing back to the stimulation generating device 110 when the subject is subjected to transcranial magnetic stimulation using the stimulation current. It can be understood that since the ratio of the magnitude of the power supply current to the magnitude of the steady-state current obtained above is less than the first threshold, that is, the power supply current is smaller than the steady-state current, the difference between the magnitude of the return current after shunting and the magnitude of the steady-state current is less than the second threshold, that is, the power supply current is less than the second threshold. For this reason, it can be approximately considered that the magnitude of the return current at this time is equal to the magnitude of the current flowing back to the stimulation generating device 110 when the subject is subjected to transcranial magnetic stimulation using the stimulation current.

[0056] It can be seen that in the embodiment of the present application, the current converter can store the electrical energy of the decaying current and release the stored electrical energy to obtain a steady-state current after steady-state conversion. Then, the steady-state current is shunted to obtain a power supply current and a return current of the stimulation generating device. The return current will flow back to the stimulation generating device and will not flow into the coil loop to generate a magnetic field, so as to conduct a transcranial magnetic sham stimulation control experiment. Moreover, the obtained power supply current can power the waveform modulator, so that the waveform modulator can provide input current to the sham stimulation response module when it is powered on, so as to improve the authenticity of the transcranial magnetic sham stimulation and reduce the influence of the subject's psychological effect on the experimental results.

[0057] Exemplarily, the waveform modulator 104 provides a first input current to the fake stimulation response module 121 on the stimulation coil 120 based on the magnitude of the stimulation current and the power supply current, so that the first response generated by the fake stimulation response module 121 is the same as the second response generated by the stimulation coil 120 when the subject is subjected to true transcranial magnetic stimulation using the stimulation current. In the embodiment of the present application, after obtaining the magnitude of the stimulation current detected by the current detection module 101, the waveform modulator 104 determines the current intensity of the stimulation current output by the stimulation generating device 110 based on the magnitude of the stimulation current when the power supply current is supplied. Thus, based on the current intensity, the first input current of the fake stimulation response module 121 is determined, and the first input current is modulated, so that the first response generated by the fake stimulation response module 121 is the same as the second response generated by the stimulation coil 120 when the subject is subjected to true transcranial magnetic stimulation using the stimulation current.

[0058] In a feasible embodiment, when providing a first input current to a sham stimulation response module on the stimulation coil based on the magnitude of the stimulation current and the power supply current, the waveform modulator 104 obtains the ratio of the magnitude of the stimulation current to the magnitude of a reference output current of the stimulation generating device; obtains a third response generated by the stimulation coil when the subject is subjected to true transcranial magnetic stimulation using the reference output current; determines a first current parameter of the first input current of the sham stimulation response module based on the above ratio and the third response; and modulates the first input current based on the first current parameter and the power supply current to provide the first input current to the sham stimulation response module.

[0059] Specifically, the waveform modulator 104 can obtain the reference output current of the stimulation generating device 110, and optionally, the reference output current can be the maximum output current of the stimulation generating device 110. In addition, the third response generated by the stimulation coil 120 when the subject is subjected to true transcranial magnetic stimulation using the reference output current is obtained. The ratio of the magnitude of the stimulation current to the reference output current is used as the current intensity of the stimulation current. It should be noted that the third response generated by the stimulation coil 120 when the subject is subjected to true transcranial magnetic stimulation using the reference output current is caused by the magnetic field generated by the stimulation current passing through the coil loop. In order to simulate the response generated by the stimulation coil 120 when the subject is subjected to false transcranial magnetic stimulation, the waveform modulator 104 can obtain the ratio of the magnitude of the stimulation current to the reference output current, thereby determining the first response that the false stimulation response module should generate based on the above ratio and the third response, so as to determine the first current parameter of the first input current required for the false stimulation response module to generate the first response. Then, based on the first current parameter and the supply current, the first input current is modulated to provide the first input current for the false stimulation response module.

[0060] Exemplarily, when obtaining the third response generated by the stimulation coil 120 when transcranial magnetic stimulation is performed on a subject using a reference output current, the waveform modulator 104 obtains the first current generated by the stimulation coil 120 when transcranial magnetic stimulation is performed on the subject using the reference output current; and / or obtains the first vibration parameter corresponding to the vibration generated by the stimulation coil 120; and / or obtains the first audio generated by the stimulation coil 120.

[0061] Specifically, when the reference output current is used to perform transcranial magnetic stimulation on the subject, the stimulation current generates a magnetic field after flowing through the coil loop, and the magnetic field acts on the subject's brain to generate an electrical stimulation current, that is, a first current. In addition, the stimulation coil 120 will generate a vibration corresponding to the first vibration parameter under the action of the magnetic field, and the stimulation coil 120 will also generate a first audio perceptible to the subject. Among them, the first vibration parameter may include, for example, vibration intensity and vibration frequency. The waveform modulator 104 will acquire and store at least one of the following third responses generated on the stimulation coil 120: the first current, the vibration corresponding to the first vibration parameter, the first audio, and so on. Optionally, at least one of the following acquisition modules may be set on the stimulation coil 120: a current sensor, a vibration sensor, a receiver, and so on, to acquire the third response generated on the stimulation coil 120, and the waveform modulator 104 will acquire and store the acquired third response.

[0062] It should be noted that under the action of the magnetic field generated by the stimulation current after flowing through the coil loop, the third response perceptible to the subject generated on the stimulation coil 120 includes at least the first current, the vibration corresponding to the first vibration parameter and the first audio frequency. When the subject is subjected to transcranial magnetic sham stimulation, at least one of the third responses can be simulated by the sham stimulation response module. Technical personnel in this field can independently set it based on experimental requirements, and no limitation is made here.

[0063] It can be seen that in the embodiment of the present application, the waveform modulator can obtain the first current generated by the stimulation coil when the subject is subjected to true transcranial magnetic stimulation using the reference output current, and / or obtain the first vibration parameter corresponding to the vibration generated by the stimulation coil, and / or obtain the first audio generated by the stimulation coil, so as to simulate the above-mentioned first current through the fake stimulation response module, and / or the vibration and / or the first audio corresponding to the first vibration parameter, thereby improving the authenticity of the fake transcranial magnetic stimulation and reducing the influence of the subject's psychological effects on the experimental results.

[0064] Furthermore, the waveform modulator 104 can determine the first current parameter of the first input current of the false stimulation response module 121 based on the ratio of the magnitude of the stimulation current to the magnitude of the reference output current of the stimulation generating device 110, and the above-mentioned collected first current, and / or the vibration of the first vibration parameter and / or the first audio.

[0065] Exemplarily, the fake stimulation response module 121 may include at least one of the following: an electrical stimulation electrode, a vibration sheet, and a speaker. The first current parameter includes at least one of the following: a target second current parameter, a target third current parameter, and a target fourth current parameter. The following description will be made by taking the fake stimulation response module 121 including the above-mentioned electrical stimulation electrode, vibration sheet, and speaker as an example. Figure 3As shown, for example, an electrical stimulation electrode 123, a vibration plate 124 and a speaker 125 may be provided on the stimulation coil 120. The waveform modulator 104 in the transcranial magnetic stimulation control device 100 is connected to the electrical stimulation electrode 123, the vibration plate 124 and the speaker 125 respectively, wherein the first output end of the waveform modulator 104 is connected to the positive electrode of the electrical stimulation electrode 123, the second output end of the waveform modulator 104 is connected to the positive electrode of the vibration plate 124, and the third output end of the waveform modulator 104 is connected to the positive electrode of the speaker 125.

[0066] It should be noted that two electrical stimulation electrodes are provided in the stimulation coil 120, which are respectively the positive electrode and the negative electrode of the electrical stimulation electrode 123, and two speakers are provided in the stimulation coil 120, which are respectively the positive electrode and the negative electrode of the speaker 125, and the connection port of the vibration plate 124 also includes a positive electrode and a negative electrode. Among them, the negative electrode of the electrical stimulation electrode 123, the negative electrode of the speaker 125 and the negative electrode of the vibration plate 124 are connected to a common ground terminal. The waveform modulator 104 modulates the target second input current of the electrical stimulation electrode 123, and / or the target third input current of the vibration plate 124 and / or the target fourth input current of the speaker 125, so that the electrical stimulation electrode 123 generates a second current equal to the first current, and / or the vibration plate 124 generates a vibration corresponding to the first vibration parameter, and / or the speaker 125 plays the first audio. Optionally, the second current can be, for example, a short-term bidirectional pulse current.

[0067] It should be noted that the electrical stimulation electrode 123, the vibration plate 124 and the speaker 125 in the embodiment of the present application can be arranged inside the stimulation coil 120, so that the appearance of the stimulation coil 120 is similar to that of a traditional stimulation coil, thereby reducing the influence of the subject's psychological effect on the experimental results.

[0068] In an embodiment of the present application, when determining the first current parameter of the first input current of the false stimulation response module based on the above-mentioned ratio and the third response, the waveform modulator 104 obtains the second current parameter of the second input current when the electrical stimulation electrode 123 is used to generate a second current equal to the first current; based on the above-mentioned ratio, the second current parameter is adjusted to obtain the target second current parameter; and / or, the third current parameter of the third input current is obtained when the vibration plate 124 is used to generate a vibration corresponding to the first vibration parameter; based on the above-mentioned ratio, the third current parameter is adjusted to obtain the target third current parameter; and / or, the fourth current parameter of the fourth input current is obtained when the speaker 125 is used to play the first audio; based on the above-mentioned ratio, the fourth current parameter is adjusted to obtain the target fourth current parameter.

[0069] It should be noted that when the electrical stimulation electrode 123 is used to generate a second current equal to the first current, the input current required by the electrical stimulation electrode 123 is the second input current. To this end, the waveform modulator 104 obtains the second current parameter of the second input current to modulate the second input current so that the second current generated by the electrical stimulation electrode 123 is equal to the first current generated by the stimulation coil 120 when the subject is subjected to transcranial magnetic stimulation using the reference output current.

[0070] Further, based on the ratio of the magnitude of the stimulation current to the magnitude of the reference output current, the second current parameter of the second input current is adjusted to obtain the target second current parameter corresponding to the target second input current. Wherein, when the input current of the electrical stimulation electrode 123 is the target second input current, the magnitude of the third current generated by the electrical stimulation electrode 123 is equal to the magnitude of the fourth current generated by the stimulation coil 120 when the subject is subjected to transcranial magnetic stimulation using the stimulation current. Optionally, the frequency of the third current is equal to the frequency of the second current, and the ratio of the amplitude of the third current to the amplitude of the second current is equal to the above ratio.

[0071] Exemplarily, when the second current parameter is adjusted based on the above ratio to obtain the target second current parameter, the waveform modulator 104 obtains the amplitude, frequency and phase corresponding to the second input current based on the second current parameter; adjusts the amplitude, frequency and phase corresponding to the second input current based on the above ratio to obtain the amplitude, frequency and phase corresponding to the target second input current; obtains the target second current parameter based on the amplitude, frequency and phase corresponding to the target second input current.

[0072] Specifically, the waveform modulator 104 can obtain the waveform corresponding to the second input current based on the second current parameters, and thus obtain the amplitude, frequency and phase corresponding to the second input current based on the waveform corresponding to the second input current. Then, based on the ratio of the magnitude of the stimulation current to the magnitude of the reference output current, the amplitude, frequency and phase corresponding to the second input current are proportionally adjusted to obtain the amplitude, frequency and phase corresponding to the target second input current. Finally, the waveform modulator 104 obtains the target second current parameters required to modulate the target second input current based on the amplitude, frequency and phase corresponding to the target second input current, thereby providing the target second input current to the electrical stimulation electrode 123 based on the target second current parameters.

[0073] Optionally, the waveform modulator 104 can proportionally reduce or amplify the waveform corresponding to the second input current based on the above ratio to obtain the waveform corresponding to the target second input current, thereby obtaining the target second current parameters required to modulate the waveform corresponding to the target second input current, and provide the target second input current to the electrical stimulation electrode 123 based on the target second current parameters.

[0074] It should be noted that the magnitude of the electrical stimulation current generated by the electrical stimulation electrode 123 may not change in proportion to the magnitude of the stimulation current output by the stimulation generating device 110. The waveform modulator 104 can also obtain a function of how the magnitude of the electrical stimulation current changes with the magnitude of the stimulation current, and provide an input current to the electrical stimulation electrode 123 based on the function. This is not limited here.

[0075] It can be seen that in the embodiment of the present application, the waveform modulator 104 can obtain the amplitude, frequency and phase corresponding to the second input current based on the second current parameter, and then adjust the amplitude, frequency and phase corresponding to the second input current based on the ratio of the magnitude of the stimulation current to the magnitude of the reference output current to obtain the amplitude, frequency and phase corresponding to the target second input current. Finally, based on the amplitude, frequency and phase corresponding to the target second input current, the target second current parameters are obtained, so as to provide the target second input current to the electrical stimulation electrode based on the target second current parameters, so that the magnitude of the third current generated by the electrical stimulation electrode is equal to the magnitude of the fourth current generated by the stimulation coil when the stimulation current is used to perform real transcranial magnetic stimulation on the subject, thereby improving the authenticity of the transcranial magnetic sham stimulation and reducing the influence of the subject's psychological effects on the experimental results.

[0076] And / or, when the vibration piece 124 is used to generate vibration corresponding to the first vibration parameter, the input current required by the vibration piece 124 is the third input current. Therefore, the waveform modulator 104 modulates the third input current by acquiring the third current parameter of the third input current, so that the vibration generated by the vibration piece 124 is the same as the vibration corresponding to the first vibration parameter generated by the stimulation coil 120 when the subject is subjected to transcranial magnetic stimulation using the reference output current. The first vibration parameter may include, for example, a first vibration frequency and a first vibration intensity.

[0077] Further, based on the ratio of the magnitude of the stimulation current to the magnitude of the reference output current, the third current parameter of the third input current is adjusted to obtain the target third current parameter corresponding to the target third input current. Wherein, when the input current of the vibration plate 124 is the target third input current, the vibration generated by the vibration plate 124 is the same as the vibration of the second vibration parameter generated by the stimulation coil 120 when the subject is subjected to transcranial magnetic stimulation using the stimulation current. Wherein, the second vibration parameter may include, for example, a second vibration frequency and a second vibration intensity. Optionally, the first vibration frequency and the second vibration frequency are equal, and the ratio of the second vibration intensity to the first vibration intensity is equal to the above ratio.

[0078] It should be noted that in the embodiment of the present application, the method of adjusting the third current parameter based on the ratio of the stimulation current to the reference output current to obtain the target third current parameter is similar to the method of adjusting the second current parameter based on the ratio of the stimulation current to the reference output current to obtain the target second current parameter, and will not be repeated here.

[0079] And / or, when the speaker 125 is used to play the first audio, the input current required by the speaker 125 is the fourth input current. To this end, the waveform modulator 104 obtains the fourth current parameter of the fourth input current to modulate the fourth input current, so that the speaker 125 plays the first audio generated by the stimulation coil 120 when the subject is subjected to transcranial magnetic stimulation using the reference output current.

[0080] Further, based on the ratio of the magnitude of the stimulation current to the magnitude of the reference output current, the fourth current parameter of the fourth input current is adjusted to obtain the target fourth current parameter corresponding to the target fourth input current. Wherein, when the input current of the speaker 125 is the target fourth input current, the second audio played by the speaker 125 is the same as the third audio generated by the stimulation coil 120 when the subject is subjected to transcranial magnetic stimulation using the stimulation current. Optionally, the ratio of the audio intensity of the second audio to the audio intensity of the first audio is equal to the above ratio.

[0081] It should be noted that in the embodiment of the present application, the method of adjusting the fourth current parameter based on the ratio of the stimulation current to the reference output current to obtain the target fourth current parameter is similar to the method of adjusting the second current parameter based on the ratio of the stimulation current to the reference output current to obtain the target second current parameter, and will not be repeated here.

[0082] It can be seen that in the embodiment of the present application, the waveform modulator can obtain the second current parameter of the second input current when the electrical stimulation electrode generates a second current equal to the magnitude of the first current, and adjust the second current parameter based on the ratio of the magnitude of the stimulation current to the magnitude of the reference output current to obtain the target second current parameter to provide the target second input current for the electrical stimulation electrode. And / or, the waveform modulator can obtain the third current parameter of the third input current when the vibration sheet generates a vibration of the first vibration parameter, and adjust the third current parameter based on the above ratio to obtain the target third current parameter to provide the vibration sheet with the target third input current. And / or, the waveform modulator can obtain the fourth current parameter of the fourth input current when the speaker plays the first audio, and adjust the fourth current parameter based on the above ratio to obtain the target fourth current parameter to provide the speaker with the target fourth input current. As a result, the electrical stimulation current generated by the electrical stimulation electrode, the vibration generated by the vibration sheet, and the audio played by the speaker are the same as the current, vibration, and audio generated by the stimulation coil when the subject is subjected to true transcranial magnetic stimulation using the stimulation current, which improves the authenticity of the transcranial magnetic sham stimulation and reduces the influence of the subject's psychological effects on the experimental results.

[0083] Finally, in the case of power supply current, the waveform modulator 104 can modulate the first input current based on the first current parameter of the fake stimulation response module 121 to provide the first input current to the fake stimulation response module 121. That is, based on the target second current parameter, the target second input current is modulated to provide the target second input current to the electrical stimulation electrode 123, based on the target third current parameter, the target third input current is modulated to provide the target third input current to the vibration sheet 124, and based on the target fourth current parameter, the target fourth input current is modulated to provide the target fourth input current to the speaker 125.

[0084] Therefore, by obtaining the ratio of the magnitude of the stimulation current to the magnitude of the reference output current of the stimulation generating device, and obtaining the third response generated by the stimulation coil when the reference output current is used to perform true transcranial magnetic stimulation on the subject, the first current parameter of the first input current of the sham stimulation response module is determined based on the above ratio and the third response, so as to provide the first input current to the sham stimulation response module based on the first current parameter and the power supply current, so that the sham stimulation response module can simulate the response generated by the stimulation coil when the stimulation current is used to perform true transcranial magnetic stimulation on the subject, thereby improving the authenticity of the sham transcranial magnetic stimulation and reducing the influence of the subject's psychological effects on the experimental results.

[0085] In a feasible embodiment, the waveform modulator 104 can directly store the reference input current of the false stimulation response module corresponding to the reference output current of the stimulation generating device 110, and obtain the first current parameter based on the ratio of the magnitude of the stimulation current to the magnitude of the reference output current, and the reference input current, and modulate the first input current.

[0086] In a feasible embodiment, when providing input current to the sham stimulation response module 121 on the stimulation coil 120 based on the magnitude of the stimulation current and the power supply current, the waveform modulator 104 can, for example, also obtain a fourth response generated by the stimulation coil 120 when the subject is subjected to true transcranial magnetic stimulation using a stimulation current with the same magnitude as the above-mentioned stimulation current; determine a first current parameter of the first input current of the sham stimulation response module based on the fourth response; and modulate the first input current based on the first current parameter and the power supply current to provide the first input current to the sham stimulation response module.

[0087] Specifically, the stimulation generating device 110 can output a plurality of stimulation currents of different current magnitudes, and the waveform modulator 104 stores the responses generated by the stimulation coil 120 when the subject is subjected to transcranial magnetic stimulation using the stimulation current of each current magnitude. To this end, the waveform modulator 104 obtains the fourth response generated by the stimulation coil 120 when the subject is subjected to transcranial magnetic stimulation using the stimulation current of the same magnitude as the above stimulation current.

[0088] Further, based on the fourth response generated by the stimulation coil 120, a first current parameter of the first input current is obtained when the fake stimulation response module 121 generates a fifth response that is the same as the fourth response. In the embodiment of the present application, the method for obtaining the first current parameter of the first input current when the fake stimulation response module generates a fifth response that is the same as the fourth response is similar to that of any of the above embodiments, and will not be repeated here.

[0089] Finally, when the power supply current is powered, based on the first current parameter, the first input current is modulated to provide the first input current for the false stimulus response module 121. In the embodiment of the present application, when the power supply current is powered, based on the first current parameter, the manner in which the first input current is modulated is similar to that of any of the above embodiments, and will not be repeated here.

[0090] It can be seen that by obtaining the fourth response of the stimulation coil when the subject is subjected to real transcranial magnetic stimulation using a stimulation current of the same magnitude as the stimulation current, and then determining the first current parameter of the first input current of the sham stimulation response module based on the fourth response, and providing the first input current to the sham stimulation response module based on the first current parameter, the sham stimulation response module can simulate the response produced by real transcranial magnetic stimulation, thereby improving the authenticity of sham transcranial magnetic stimulation and reducing the influence of the subject's psychological effects on the experimental results.

[0091] In a possible embodiment, if Figure 4 As shown, the transcranial magnetic stimulation control device 100 may further include a stimulation control switch 105. The first end of the stimulation control switch 105 is connected to the positive output end of the stimulation generating device 110, the second end of the stimulation control switch 105 is connected to the enable end of the current attenuator 102, and the third end of the stimulation control switch 105 is connected to the coil loop 122 of the stimulation coil 120.

[0092] It should be noted that in the embodiment of the present application, when the subjects are subjected to real transcranial magnetic stimulation and sham transcranial magnetic stimulation, the stimulation coil 120 used is the same stimulation coil. Compared with the traditional real transcranial magnetic stimulation and sham transcranial magnetic stimulation that use two different stimulation coils, the transcranial magnetic sham stimulation in the embodiment of the present application is more authentic and reduces the influence of the subjects' psychological effects on the experimental results.

[0093] Exemplarily, when a subject is subjected to transcranial magnetic sham stimulation, the stimulation control switch 105 enables the current attenuator 102 and turns off the coil loop 122 so that the stimulation current flows to the current attenuator 102. It should be noted that the stimulation control switch 105 is connected to the enable end of the current attenuator 102, and the current attenuator 102 only works when the enable end signal is turned on. Thus, the current attenuator 102 can be enabled by the stimulation control switch 105, and the stimulation current at this time will not pass through the coil loop 122 of the stimulation coil 120, that is, no magnetic field will be generated on the stimulation coil 120. After the stimulation current flows through the current attenuator 102 and the current converter 103, it flows back to the stimulation generating device 110, and the experimental results at this time are used as the control group of the experimental results of transcranial magnetic real stimulation. Among them, the processing method of the stimulation current by the current detection module 101, the current attenuator 102, the current converter 103 and the waveform modulator 104 is similar to the method of any of the above embodiments, and will not be repeated here.

[0094] When the subject is subjected to true transcranial magnetic stimulation, the stimulation control switch 105 turns off the current attenuator 102 and connects the coil loop 122, so that the stimulation current flows through the coil loop 122. When the stimulation control switch 105 does not provide an enable signal to the current attenuator 102, the current attenuator 102 is turned off. At this time, the stimulation current generates a magnetic field after flowing through the coil loop 122. By comparing the experimental results at this time with the experimental results of sham transcranial magnetic stimulation, the therapeutic effect of transcranial magnetic stimulation can be obtained.

[0095] Therefore, by controlling the working state of the current attenuator and the on-off of the coil loop through the stimulation control switch, a control experiment of real transcranial magnetic stimulation and sham transcranial magnetic stimulation can be carried out on the subjects to obtain the therapeutic effect of transcranial magnetic stimulation on the disease. The therapeutic effect at this time eliminates the influence of the subjects' psychological effects on the experimental results and improves the accuracy of the experiment.

[0096] In summary, in the embodiment of the present application, when a subject is subjected to transcranial magnetic sham stimulation, the magnitude of the stimulation current output by the stimulation generating device is detected by the current detection module, and then the stimulation current is attenuated by the current attenuator to obtain an attenuated current, and the attenuated current is converted by the current converter to provide a power supply current for the waveform modulator. Then, the waveform modulator provides a first input current to the sham stimulation response module on the stimulation coil based on the magnitude of the stimulation current and the power supply current, so that the first response generated by the sham stimulation response module is the same as the second response generated by the stimulation coil when the subject is subjected to transcranial magnetic real stimulation using the stimulation current. Thus, the transcranial magnetic sham stimulation device can, based on the magnitude of the stimulation current, cause the sham stimulation response module on the stimulation coil to generate the same response as the transcranial magnetic real stimulation using the stimulation current, so that the subject experiences the same sensory stimulation as the transcranial magnetic real stimulation, thereby improving the authenticity of the transcranial magnetic sham stimulation and reducing the influence of the subject's psychological effects on the experimental results when conducting a control experiment.

[0097] It should be noted that the above-mentioned current detection module, current attenuator, current converter and waveform modulator can be actual functional modules or logically divided functional modules, and the present application does not limit this.

[0098] In a feasible embodiment, the transcranial magnetic stimulation control device can also be arranged inside the stimulation coil as a functional module of the stimulation coil. The embodiment of the present application only takes the transcranial magnetic stimulation control device and the stimulation coil as two different devices as an example for explanation. The processing method when the transcranial magnetic stimulation control device is arranged inside the stimulation coil is similar to that in the embodiment of the present application, and will not be repeated here.

[0099] See also Figure 5 , Figure 5 A flow chart of a transcranial magnetic sham stimulation response method provided in an embodiment of the present application. The method is applied to the above-mentioned transcranial magnetic sham stimulation device 200. The method includes but is not limited to the following steps:

[0100] S501: When performing sham transcranial magnetic stimulation on a subject, detecting the magnitude of the stimulation current output by the stimulation generating device.

[0101] S502: Attenuate the stimulation current to obtain an attenuated current.

[0102] S503: Convert the attenuation current to provide a power supply current for the waveform modulator.

[0103] S504: Based on the magnitude of the stimulation current and the power supply current, a first input current is provided to the sham stimulation response module on the stimulation coil, so that a first response generated by the sham stimulation response module is the same as a second response generated by the stimulation coil when the subject is subjected to real transcranial magnetic stimulation using the stimulation current.

[0104] The specific implementation process of steps S501 to S504 may refer to the specific functions of the above-mentioned current detection module, current attenuator, current converter and waveform modulator, which will not be described in detail here.

[0105] See also Figure 6 , Figure 6 This is a schematic diagram of the structure of an electronic device provided in an embodiment of the present application. Figure 6 As shown, the electronic device 600 includes a transceiver 601, a processor 602 and a memory 603. They are connected via a bus 604. The memory 603 is used to store computer programs and data, and can transmit the data stored in the memory 603 to the processor 602. The electronic device 600 can be the above-mentioned transcranial magnetic sham stimulation device 200. The processor 602 is used to read the computer program in the memory 603 to execute the various steps of the transcranial magnetic sham stimulation response method of the embodiment of the present application.

[0106] The processor 602 can be a general-purpose central processing unit (CPU), a microprocessor, an application-specific integrated circuit (ASIC), a graphics processing unit (GPU) or one or more integrated circuits, which are used to execute relevant programs to implement the functions required to be performed by the units in the transcranial magnetic sham stimulation device, or to execute the transcranial magnetic sham stimulation response method of the method embodiment of the present application.

[0107] The processor 602 may also be an integrated circuit chip with signal processing capabilities. In the implementation process, each step in the transcranial magnetic pseudo-stimulation response method of the present application may be completed by an integrated logic circuit of hardware or software instructions in the processor 602. The above-mentioned processor 602 may also be a general-purpose processor, a digital signal processor (DSP), an application-specific integrated circuit (ASIC), a field programmable gate array (FPGA) or other programmable logic devices, discrete gates or transistor logic devices, discrete hardware components. The methods, steps and logic block diagrams disclosed in the embodiments of the present application may be implemented or executed. The general-purpose processor may be a microprocessor or the processor may also be any conventional processor, etc. The steps of the method disclosed in the embodiments of the present application may be directly embodied as being executed by a hardware decoding processor, or may be executed by a combination of hardware and software modules in a decoding processor. The software module may be located in a mature storage medium in the art such as a random access memory, a flash memory, a read-only memory, a programmable read-only memory or an electrically erasable programmable memory, a register, etc. The storage medium is located in the memory 603, and the processor 602 reads the information in the memory 603, and combines its hardware to complete the functions required to be performed by the units included in the transcranial magnetic sham stimulation device of the embodiment of the present application, or executes the various steps in the transcranial magnetic sham stimulation response method of the method embodiment of the present application.

[0108] The transceiver 601 is used to realize the communication between the electronic device 600 and other devices or communication networks. Specifically, the transceiver 601 can be the above-mentioned current detection module. For example, the magnitude of the stimulation current output by the stimulation generating device can be detected by the transceiver 601.

[0109] The bus 604 may include a path for transmitting information between various components of the electronic device 600 (eg, the transceiver 601 , the processor 602 , and the memory 603 ).

[0110] It should be noted that although Figure 6 The electronic device 600 shown only shows a transceiver, a memory, and a processor, but in the specific implementation process, those skilled in the art should understand that the electronic device 600 also includes other devices necessary for normal operation. At the same time, according to specific needs, those skilled in the art should understand that the electronic device 600 may also include hardware devices for implementing other additional functions. In addition, those skilled in the art should understand that the electronic device 600 may also only include the devices necessary for implementing the embodiments of the present application, and does not necessarily include Figure 6 All devices shown in .

[0111] Those skilled in the art can clearly understand that, for the convenience and brevity of description, the specific working processes of the above-described equipment, devices and units can refer to the corresponding processes in the aforementioned method embodiments and will not be repeated here.

[0112] An embodiment of the present application also provides a computer-readable storage medium, which stores a computer program. The computer program is executed by a processor to implement part or all of the steps of any one of the transcranial magnetic pseudo-stimulation response methods described in the above method embodiments.

[0113] An embodiment of the present application also provides a computer program product, which includes a non-transitory computer-readable storage medium storing a computer program, and the computer program is operable to cause a computer to execute part or all of the steps of any one of the transcranial magnetic pseudo-stimulation response methods recorded in the above method embodiments.

[0114] It should be noted that, for the aforementioned method embodiments, for the sake of simplicity, they are all expressed as a series of action combinations, but those skilled in the art should be aware that the present application is not limited by the described order of actions, because according to the present application, certain steps can be performed in other orders or simultaneously. Secondly, those skilled in the art should also be aware that the embodiments described in the specification are all optional embodiments, and the actions and modules involved are not necessarily required by the present application.

[0115] In the above embodiments, the description of each embodiment has its own emphasis. For parts that are not described in detail in a certain embodiment, reference can be made to the relevant descriptions of other embodiments.

[0116] In the several embodiments provided in the present application, it should be understood that the disclosed device can be implemented in other ways. For example, the device embodiments described above are only schematic, such as the division of the units, which is only a logical function division. There may be other division methods in actual implementation, such as multiple units or components can be combined or integrated into another system, or some features can be ignored or not executed. Another point is that the mutual coupling or direct coupling or communication connection shown or discussed can be through some interfaces, and the indirect coupling or communication connection of the device or unit can be electrical or other forms.

[0117] The units described as separate components may or may not be physically separated, and the components shown as units may or may not be physical units, that is, they may be located in one place or distributed on multiple network units. Some or all of the units may be selected according to actual needs to achieve the purpose of the solution of this embodiment.

[0118] In addition, each functional unit in each embodiment of the present application may be integrated into one processing unit, or each unit may exist physically separately, or two or more units may be integrated into one unit. The above-mentioned integrated unit may be implemented in the form of hardware or in the form of a software program module.

[0119] If the integrated unit is implemented in the form of a software program module and sold or used as an independent product, it can be stored in a computer-readable memory. Based on this understanding, the technical solution of the present application, or the part that contributes to the prior art, or all or part of the technical solution can be embodied in the form of a software product. The computer software product is stored in a memory, including a number of instructions to enable a computer device (which can be a personal computer, server or network device, etc.) to execute all or part of the steps of the method described in each embodiment of the present application. The aforementioned memory includes: U disk, read-only memory (ROM, Read-Only Memory), random access memory (RAM, Random Access Memory), mobile hard disk, disk or optical disk and other media that can store program codes.

[0120] Those skilled in the art will appreciate that all or part of the steps in the various methods of the above embodiments may be completed by instructing related hardware through a program, and the program may be stored in a computer-readable memory, which may include a flash drive, a read-only memory (ROM), a random access memory (RAM), a magnetic disk or an optical disk, etc.

[0121] The embodiments of the present application are introduced in detail above. Specific examples are used in this article to illustrate the principles and implementation methods of the present application. The description of the above embodiments is only used to help understand the method and core idea of ​​the present application. At the same time, for general technical personnel in this field, according to the idea of ​​the present application, there will be changes in the specific implementation method and application scope. In summary, the content of this specification should not be understood as a limitation on the present application.

Claims

1. A transcranial magnetic sham stimulation device, characterized in that: The transcranial magnetic sham stimulation device comprises: a transcranial magnetic stimulation control device, a stimulation generating device and a stimulation coil; a sham stimulation response module is arranged on the stimulation coil; The transcranial magnetic stimulation control device comprises: a current detection module, a current attenuator, a current converter and a waveform modulator; When the subject is subjected to sham transcranial magnetic stimulation, the current detection module is used to detect the magnitude of the stimulation current output by the stimulation generating device; The current attenuator is used to attenuate the stimulation current to obtain an attenuated current; The current converter is used to convert the attenuation current to provide a power supply current for the waveform modulator; The waveform modulator is used to provide a first input current to the sham stimulation response module on the stimulation coil based on the magnitude of the stimulation current and the power supply current, so that the first response generated by the sham stimulation response module is the same as the second response generated by the stimulation coil when the subject is subjected to real transcranial magnetic stimulation using the stimulation current; the sham stimulation response module includes at least one of the following: an electrical stimulation electrode, a vibration sheet, and a speaker; Specifically used for: Obtaining the ratio of the magnitude of the stimulation current to the magnitude of the reference output current of the stimulation generating device; When performing transcranial magnetic stimulation on a subject using the reference output current, obtaining a first current generated by the stimulation coil, a first vibration parameter corresponding to the vibration generated by the stimulation coil, and a first audio frequency generated by the stimulation coil; Acquire a second current parameter of a second input current when the electrical stimulation electrode is used to generate a second current having a magnitude equal to that of the first current; adjust the second current parameter based on the ratio to obtain a target second current parameter; Acquire a third current parameter of a third input current when the vibration sheet is used to generate a vibration corresponding to the first vibration parameter; adjust the third current parameter based on the ratio to obtain a target third current parameter; Acquire a fourth current parameter of a fourth input current generated by the speaker when playing the first audio; adjust the fourth current parameter based on the ratio to obtain a target fourth current parameter; When the power supply current is supplied, the target second input current is modulated based on the target second current parameter to provide the target second input current to the electrical stimulation electrode, the target third input current is modulated based on the target third current parameter to provide the target third input current to the vibration plate, and the target fourth input current is modulated based on the target fourth current parameter to provide the target fourth input current to the speaker.

2. The transcranial magnetic sham stimulation device according to claim 1, characterized in that: In terms of providing a first input current to the sham stimulation response module on the stimulation coil based on the magnitude of the stimulation current and the power supply current, the waveform modulator is specifically used to: Acquire a fourth response generated by the stimulation coil when the subject is subjected to transcranial magnetic stimulation using a stimulation current having the same magnitude as the stimulation current; Based on the fourth response, determining a first current parameter of the false stimulus response module; The first input current is modulated based on the first current parameter and the supply current to provide the first input current for the false stimulus response module.

3. The transcranial magnetic sham stimulation device according to claim 1, characterized in that: In terms of adjusting the second current parameter based on the ratio to obtain a target second current parameter, the waveform modulator is specifically used to: Based on the second current parameter, obtaining the amplitude, frequency and phase corresponding to the second input current; Based on the ratio, adjusting the amplitude, frequency and phase corresponding to the second input current to obtain the amplitude, frequency and phase corresponding to the target second input current; The target second current parameter is obtained based on the amplitude, frequency and phase corresponding to the target second input current.

4. The transcranial magnetic sham stimulation device according to claim 3, characterized in that: The transcranial magnetic stimulation control device also includes a stimulation control switch; When the subject is subjected to the transcranial magnetic sham stimulation, the stimulation control switch is used to enable the current attenuator and cut off the coil loop so that the stimulation current flows to the current attenuator; When the subject is subjected to the transcranial magnetic stimulation, the stimulation control switch is used to turn off the current attenuator and connect the coil loop so that the stimulation current flows through the coil loop.

5. The transcranial magnetic sham stimulation device according to any one of claims 1 to 4, characterized in that: In the aspect of converting the attenuation current, the current converter is specifically used for: storing the electric energy of the decaying current; The electric energy is released, and the released current is filtered to obtain a steady-state current; The steady-state current is split to obtain the power supply current and the return current of the stimulation generating device.

6. An electronic device, characterized in that: include: A processor and a memory, wherein the processor is connected to the memory, the memory is used to store a computer program, and the processor is used to execute the computer program stored in the memory, so that the electronic device performs the following steps: When the subject is subjected to sham transcranial magnetic stimulation, the magnitude of the stimulation current output by the stimulation generating device is detected; Attenuating the stimulation current to obtain an attenuated current; converting the attenuated current to provide a supply current for a waveform modulator; Based on the magnitude of the stimulation current and the power supply current, a first input current is provided to a sham stimulation response module on the stimulation coil, so that a first response generated by the sham stimulation response module is the same as a second response generated by the stimulation coil when the subject is subjected to real transcranial magnetic stimulation using the stimulation current; the sham stimulation response module comprises at least one of the following: an electrical stimulation electrode, a vibration sheet, and a speaker; Specifically used for: Obtaining the ratio of the magnitude of the stimulation current to the magnitude of the reference output current of the stimulation generating device; When performing transcranial magnetic stimulation on a subject using the reference output current, obtaining a first current generated by the stimulation coil, a first vibration parameter corresponding to the vibration generated by the stimulation coil, and a first audio frequency generated by the stimulation coil; Acquire a second current parameter of a second input current when the electrical stimulation electrode is used to generate a second current having a magnitude equal to that of the first current; Based on the ratio, adjusting the second current parameter to obtain a target second current parameter; acquiring a third current parameter of a third input current when the vibration sheet is used to generate a vibration corresponding to the first vibration parameter; Based on the ratio, adjusting the third current parameter to obtain a target third current parameter; Acquire a fourth current parameter of a fourth input current generated by the speaker when playing the first audio; Based on the ratio, adjusting the fourth current parameter to obtain a target fourth current parameter; When the power supply current is supplied, the target second input current is modulated based on the target second current parameter to provide the target second input current to the electrical stimulation electrode, the target third input current is modulated based on the target third current parameter to provide the target third input current to the vibration plate, and the target fourth input current is modulated based on the target fourth current parameter to provide the target fourth input current to the speaker.

7. A computer-readable storage medium, characterized in that: The computer readable storage medium stores a computer program, and the computer program is executed by a processor to implement the following steps: When the subject is subjected to sham transcranial magnetic stimulation, the magnitude of the stimulation current output by the stimulation generating device is detected; Attenuating the stimulation current to obtain an attenuated current; converting the attenuated current to provide a supply current for a waveform modulator; Based on the magnitude of the stimulation current and the power supply current, a first input current is provided to a sham stimulation response module on the stimulation coil, so that a first response generated by the sham stimulation response module is the same as a second response generated by the stimulation coil when the subject is subjected to real transcranial magnetic stimulation using the stimulation current; the sham stimulation response module comprises at least one of the following: an electrical stimulation electrode, a vibration sheet, and a speaker; Specifically used for: Obtaining the ratio of the magnitude of the stimulation current to the magnitude of the reference output current of the stimulation generating device; When performing transcranial magnetic stimulation on a subject using the reference output current, obtaining a first current generated by the stimulation coil, a first vibration parameter corresponding to the vibration generated by the stimulation coil, and a first audio frequency generated by the stimulation coil; Acquire a second current parameter of a second input current when the electrical stimulation electrode is used to generate a second current having a magnitude equal to that of the first current; Based on the ratio, adjusting the second current parameter to obtain a target second current parameter; acquiring a third current parameter of a third input current when the vibration sheet is used to generate a vibration corresponding to the first vibration parameter; Based on the ratio, adjusting the third current parameter to obtain a target third current parameter; Acquire a fourth current parameter of a fourth input current generated by the speaker when playing the first audio; Based on the ratio, adjusting the fourth current parameter to obtain a target fourth current parameter; When the power supply current is supplied, the target second input current is modulated based on the target second current parameter to provide the target second input current to the electrical stimulation electrode, the target third input current is modulated based on the target third current parameter to provide the target third input current to the vibration plate, and the target fourth input current is modulated based on the target fourth current parameter to provide the target fourth input current to the speaker.

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