Mixing tube, production process and blood collection device for mixing blood sedimentation in capillary tube

Abstract

The present application relates to a mixing tube for mixing erythrocyte sedimentation rate enclosed in a capillary, and relates to the technical field of medical devices, which includes a mixing tube body, the mixing tube body is slidably arranged in the capillary, the outer diameter of the mixing tube body and the outer diameter of the capillary are 0.48-0.68, the inner diameter ratio of the mixing tube body and the capillary is 0.46-0.69, the outer diameter of the capillary is 1.9-2.3mm, the inner diameter of the capillary is 1.3-1.5mm, the outer diameter of the outer diameter of the mixing tube body is 1.1-1.3mm, and the inner diameter of the mixing tube body is 0.7-0.9mm. The present application has the effect of facilitating the efficiency of mixing blood samples in the blood sampler by technicians, reducing costs and reducing the erythrocyte sedimentation rate of blood samples in the capillary of the blood sampler, and improving the accuracy of subsequent blood gas analysis.

Description

Technical Field

[0001] The present application relates to the technical field of medical devices, and in particular to a mixing tube sealed in a capillary tube for mixing erythrocyte sedimentation. Background Art

[0002] A micro blood gas sampler is a small, portable device that is mainly used in clinical and research laboratories. It often uses a micro needle to puncture the patient's skin and blood vessels, then enters the blood vessels through the micropores and collects a trace amount of blood into the blood sampler for collection and subsequent blood gas analysis.

[0003] When the blood gas is analyzed later, the test personnel need to use a sampling needle to extract the blood sample in the blood collector and transfer it to the blood gas analyzer for blood gas analysis. In large physical examination environments such as hospitals and schools, blood is often collected centrally and then analyzed centrally. During the storage of the blood collector after blood collection, the blood sample in the blood collector is prone to erythrocyte sedimentation rate. In the subsequent blood gas analysis, in order to ensure the accuracy of the test results, the blood collector is often shaken and mixed to reduce the erythrocyte sedimentation rate. Since the capillary inner diameter of the micro blood gas collector is small, it is not easy to mix the blood sample in the blood collector directly by hand shaking. When mixing, a special medical shaking device is often used to place the blood collector on the shaking device for shaking.

[0004] However, in the actual testing process, the use of dedicated shaking equipment for mixing is inefficient and costly, so this needs to be improved. Summary of the invention

[0005] In order to facilitate the technicians to mix the blood sample in the blood collector efficiently, reduce costs and reduce the erythrocyte sedimentation rate of the blood sample in the capillary of the blood collector, and improve the accuracy of subsequent blood gas analysis, the present application provides a mixing tube enclosed in a capillary for mixing the erythrocyte sedimentation rate.

[0006] The present application provides a mixing tube for mixing erythrocyte sedimentation enclosed in a capillary tube, which adopts the following technical solution:

[0007] A mixing tube enclosed in a capillary for mixing erythrocyte sedimentation comprises a mixing tube body which is slidably arranged in the capillary, wherein the ratio of the outer diameter of the mixing tube body to the outer diameter of the capillary is 0.48-0.68, and the ratio of the inner diameter of the mixing tube body to the capillary is 0.46-0.69.

[0008] By adopting the above technical solution, by setting the size of the mixing tube body and the capillary in this ratio, the sliding of the mixing tube body in the capillary is facilitated. In actual use, under the same mixing conditions, when the size of the mixing tube body and the capillary is in this ratio, the mixing tube body has a more sufficient mixing effect on the blood sample when it moves in the capillary. When using a magnet to pull the mixing tube body to move in the capillary, the mixing tube body only needs to slide back and forth three times in the capillary to achieve mixing of the blood sample.

[0009] Preferably, the outer diameter of the capillary is 1.9-2.3 mm, the inner diameter of the capillary is 1.3-1.5 mm, the outer diameter of the mixing tube body is 1.1-1.3 mm, and the inner diameter of the mixing tube body is 0.7-0.9 mm.

[0010] Preferably, the surface finish of the mixing tube body is Ra10, the inner wall and the outer periphery of the mixing tube body are anticoagulant treated, and the anticoagulant used in the anticoagulant treatment of the mixing tube is a heparin solution containing 10-50 units per milliliter of physiological saline.

[0011] A production process of a mixing tube for mixing blood sedimentation in a capillary tube, comprising the following processes: S1, pretreatment, firstly cleaning the oil stains on the surface of the stainless steel tube by washing;

[0012] S2, rough grinding, move the stainless steel pipe into the polishing equipment, use mechanical grinding and physical polishing to perform preliminary grinding on the surface of the stainless steel pipe, at this time the outer surface of the stainless steel pipe reaches Ra20;

[0013] S3, pickling and electrolytic polishing, the initially polished stainless steel pipe is further moved into the pickling and electrolytic equipment, and the outer and inner surfaces of the stainless steel pipe are finely polished. At this time, the finish of the outer and inner surfaces of the stainless steel pipe reaches Ra10;

[0014] S4, surface cleaning and internal cleaning, moving the stainless steel pipe after pickling and electrolysis into the water washing and testing equipment to clean the polished stainless steel pipe and perform surface and internal finish testing of the stainless steel pipe;

[0015] S5, anticoagulation treatment of the stainless steel tube, cutting the cleaned and tested stainless steel tube into a specified size and immersing the cut stainless steel tube in a 1250U / mol heparin solution for anticoagulation treatment.

[0016] By controlling the size of the mixing tube body and the smoothness of the surface of the mixing tube body, the breakage of red blood cells by the mixing tube body when it moves in the capillary can be reduced, thereby improving the accuracy of the test results.

[0017] Optionally, the pickling electrolysis equipment in step S3 includes a pickling tank body, a clamping component arranged in the pickling tank body to clamp the stainless steel pipe, and a processing component arranged in the pickling tank to process the precipitate.

[0018] A blood collector comprises a shell, a U-shaped capillary arranged in the shell, a Luer head arranged at the front end of the shell and connected to one end of the capillary, and a sealing interface arranged at the front end of the shell and connected to the other end of the capillary, wherein a sealing head is detachably provided at the sealing interface, two mixing tube bodies are arranged in the capillary, and the mixing tube bodies are slidably arranged in the capillary, and a hemostatic component is also provided in the shell.

[0019] Optionally, a sealing piece is provided in the Luer head, and the sealing piece is a rubber sealing ring provided in the Luer head, the rubber sealing ring is hollow, and the inner diameter of the rubber sealing ring is smaller than the diameter of the end side of the capillary tube.

[0020] By setting the inner diameter of the rubber sealing ring to be smaller than the diameter of the end side of the capillary tube, the rubber sealing ring limits the mixing tube body, making it difficult for the mixing tube body to slip out of the capillary tube, thereby ensuring that the mixing tube body can efficiently mix the erythrocyte sedimentation rate.

[0021] Optionally, the sampling probe of the sampling instrument has a diameter of 0.9 mm-1.3 mm, so the inner diameter of the rubber sealing ring is between 0.8 mm-1.2 mm, and the inner circumferential wall of the rubber sealing ring is movably pressed against the outer circumferential wall of the sampling probe.

[0022] Due to the characteristics of the blood gas detector itself, an alarm will be generated when the sampling probe of the blood gas detector does not take sufficient samples, and an alarm will also be generated when the probe encounters an obstruction. When the sampling probe is inserted into the blood sampler for sampling, if the sampling probe is inserted into one end of the blood sampler without being sealed, it is easy for the blood sampler to take in air from the outer wall of the sampling probe and the inner wall of the Luer head, thereby causing the liquid level at the blood drawing end of the blood sampler to lower, which can easily cause insufficient sampling of the blood gas detector and affect the test results.

[0023] At the same time, when sampling is carried out by forward airflow, since the sampling probe of the blood gas detector is often arranged at an angle, when the blood sampler is also arranged at an angle, the blood sample is easy to flow out from the gap between the sampling probe and the inner wall of the blood sampler, which can easily cause blood sample waste and occupational exposure of medical staff.

[0024] By setting the inner diameter of the rubber sealing ring between 0.8-1.2mm and pressing against the outer wall of the sampling probe, a seal is formed at the sampling end of the sampling probe, thereby achieving rear air intake during blood gas testing. When the sampling probe samples the blood sample in the blood collector, the liquid level at the other end of the capillary away from the sampling probe lowers, so that the sampling probe is always in contact with the blood sample, which is convenient for the technician to fully sample. At this time, the rubber sealing ring blocks the sampling probe, and the blood sample is not easy to flow out of the sampling probe, thereby reducing occupational exposure. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 It is a schematic diagram of the overall structure of a blood sampling device in an embodiment of the present application;

[0026] Figure 2 It is a schematic diagram of the connection structure of the pickling electrolysis equipment in the mixing tube production process of the present application;

[0027] Figure 3 It is a schematic diagram of the connection structure of two clamping blocks in the pickling electrolysis equipment;

[0028] Figure 4 is a schematic diagram of the connection structure of the wiping component;

[0029] Figure 5 It is a schematic diagram of the connection structure of the processing components;

[0030] Figure 6 It is a schematic diagram of the connection structure when the clamping block is taken out from the rotating shaft.

[0031] Reference numerals: 1, housing; 11, capillary tube; 12, mixing tube body; 13, Luer connector; 14, sealing interface; 15, hemostatic element; 16, sealing plug; 17, rubber sealing ring; 2, pickling tank body; 3, clamping assembly; 31, rotating shaft; 311, synchronous gear; 32, clamping block; 33, receiving groove; 34, positioning element; 341, positioning block; 342, positioning groove; 343, positioning spring; 35, connecting pipe; 36, first connecting port; 351, pressurizing element; 37. Connecting channel; 38. Limiting groove; 39. Tightening ring; 381. Drain port; 4. Limiting assembly; 41. Limiting block; 42. Limiting hole; 43. Movable groove; 44. Limiting spring; 45. Fixed rod; 5. Wiping assembly; 51. Sliding block; 52. Rotating screw; 53. Wiping block; 54. Wiping groove; 55. Wiping sponge; 6. Processing assembly; 61. Filter plate; 62. Filter hole; 63. Collecting box; 64. Scraper; 65. Synchronous screw; 66. Driven gear. DETAILED DESCRIPTION

[0032] The present application is further described in detail below in conjunction with examples. The following examples are only used to illustrate the present invention and should not be construed as limiting the scope of the present invention. In the following examples, if specific conditions are not specified, they are carried out according to normal conditions or conditions recommended by the manufacturer. The methods used are conventional methods known in the art unless otherwise specified, and the consumables and reagents used are commercially available unless otherwise specified. Unless otherwise specified, the professional and scientific terms used herein have the same meaning as those familiar to those skilled in the art. In addition, any method or material similar or equivalent to the recorded content may also be applied to the present invention.

[0033] The present application first discloses a mixing tube for mixing blood sedimentation in a capillary tube 11 and a blood sampling device, first referring to Figure 1 A blood collector comprises a shell 1, a U-shaped capillary 11 arranged in the shell 1, a mixing tube body 12 slidably arranged in the capillary 11, a Luer connector 13 arranged on the shell 1 and a sealing interface 14 arranged on the shell 1, the sealing interface 14 and the Luer head are both arranged on the same end side of the shell 1, the sealing interface 14 is connected to one end of the capillary 11, and the Luer head is connected to the other end of the capillary 11. In the present application, the smoothness of the outer circumferential wall and the inner circumferential wall of the mixing tube body 12 are both Ra10, the capillary 11 is an integrally formed arrangement, and a hemostatic member 15 is provided on the inner side wall of the shell 1 near the sealing interface 14. The hemostatic member 15 is a medical polyethylene porous structure, and the pores of the hemostatic member 15 are filled with polymer elastic colloid particles. The colloid particles expand when encountering liquid, so that the hemostatic member 15 cannot be ventilated, thereby preventing the liquid from passing through, realizing the function of stopping sampling, and reducing the blood waste and occupational exposure caused by blood overflowing from the sealing interface 14 due to excessive sampling.

[0034] Also refer to Figure 1 A sealing plug 16 is detachably provided at the sealing interface 14 of the housing 1 , and the sealing plug 16 is movably inserted into the sealing interface 14 , and the outer peripheral wall of the sealing plug 16 is movably pressed against the inner peripheral wall of the sealing interface 14 .

[0035] A rubber sealing ring 17 is provided between the Luer head of the housing 1 and the capillary tube 11 . The rubber sealing ring 17 is hollow and has an inner diameter of 0.8-1.2 mm, that is, the rubber sealing ring 17 movably seals the end side of the capillary tube 11 .

[0036] After blood sampling, it is necessary to conduct on-machine testing. The blood gas analyzer extracts and tests the blood sample in the blood sampler through a sampling probe. During the extraction and testing, the blood sampler is often arranged at an angle. If the sampling probe is directly inserted into the Luer head to extract the blood sample, if the outer peripheral wall of the sampling probe is not covered and sealed, the blood sample in the capillary 11 will take in air from the Luer head as the sampling probe is extracted, causing the blood sample liquid level at the end of the capillary 11 close to the Luer to decrease, which is likely to cause insufficient sampling. The rubber sealing ring 17 is set in this form. During the on-machine testing, the rubber sealing ring 17 covers the sampling probe. At this time, the technician takes in air after sampling through the sealing plug 16 at the sealing interface 14. During sampling, as the sampling probe takes samples, the blood sample liquid level in the capillary 11 close to the sealing interface 14 decreases, thereby facilitating the sampling operation of the sampling probe.

[0037] The sealing plug 16 and the rubber sealing ring 17 are matched with each other to reduce the problem that the mixing tube body 12 slips out of the capillary tube 11 .

[0038] Based on the above structure, the outer diameter of the capillary 11 is 1.9-2.3 mm, the inner diameter of the capillary 11 is 1.3-1.5 mm, the outer diameter of the mixing tube body 12 is 1.-1.3 mm, and the inner diameter of the mixing tube body 12 is 0.7-0.9 mm.

[0039] The ratio of the inner diameter of the mixing tube body 12 to the inner diameter of the capillary 11 is 0.48-0.68, and the ratio of the outer diameter of the mixing tube body 12 to the inner diameter of the capillary 11 is 0.73-1.

[0040] In order to reflect the best size ratio between the mixing tube body 12 and the capillary 11, the mixing tube body 12 and the capillary 11 with different size ratios are assembled to form different blood collectors, and then the venous blood of healthy adult males from the same source is taken as the test sample, and the same amount of blood samples are taken with different blood collectors. The blood collector is placed vertically for 20 minutes, and then shaken three times with a shaking device. The sampling needle is inserted 4 cm into the capillary 11 at one end of the Luer head for sampling. The sampled blood is observed through an electron microscope, and the red blood cells and broken red blood cells in the unit area are counted to calculate the red blood cell concentration and the red blood cell damage ratio in the blood.

[0041] Example 1

[0042] In Example 1 of the present application, the ratio of the outer diameter of the mixing tube body 12 to the inner diameter of the capillary tube 11 is 0.73, and the ratio of the inner diameter of the mixing tube body 12 to the inner diameter of the capillary tube 11 is 0.48;

[0043] Example 2

[0044] In Example 2 of the present application, the ratio of the outer diameter of the mixing tube body 12 to the inner diameter of the capillary 11 is 0.73, and the ratio of the inner diameter of the mixing tube body 12 to the inner diameter of the capillary 11 is 0.53;

[0045] Example 3

[0046] In Example 3 of the present application, the ratio of the outer diameter of the mixing tube body 12 to the inner diameter of the capillary 11 is 0.81, and the ratio of the inner diameter of the mixing tube body 12 to the inner diameter of the capillary 11 is 0.53;

[0047] Example 4

[0048] In Example 4 of the present application, the ratio of the outer diameter of the mixing tube body 12 to the inner diameter of the capillary 11 is 0.81, and the ratio of the inner diameter of the mixing tube body 12 to the inner diameter of the capillary 11 is 0.68;

[0049] Example 5

[0050] In Example 5 of the present application, the ratio of the outer diameter of the mixing tube body 12 to the inner diameter of the capillary 11 is 0.93, and the ratio of the inner diameter of the mixing tube body 12 to the inner diameter of the capillary 11 is 0.68;

[0051] Example 6

[0052] In Example 6 of the present application, the ratio of the outer diameter of the mixing tube body 12 to the inner diameter of the capillary tube 11 is 0.93, and the ratio of the inner diameter of the mixing tube body 12 to the inner diameter of the capillary tube 11 is 0.75;

[0053] Example 7

[0054] In Example 7 of the present application, the ratio of the outer diameter of the mixing tube body 12 to the inner diameter of the capillary tube 11 is 1.00, and the ratio of the inner diameter of the mixing tube body 12 to the inner diameter of the capillary tube 11 is 0.71;

[0055] Example 8

[0056] In Example 8 of the present application, the ratio of the outer diameter of the mixing tube body 12 to the inner diameter of the capillary tube 11 is 1.00, and the ratio of the inner diameter of the mixing tube body 12 to the inner diameter of the capillary tube 11 is 0.8;

[0057] Comparative Example 1

[0058] In comparative example 1 of the present application, the ratio of the outer diameter of the mixing tube body 12 to the inner diameter of the capillary tube 11 is 0.52, and the ratio of the inner diameter of the mixing tube body 12 to the inner diameter of the capillary tube 11 is 0.3;

[0059] Comparative Example 2

[0060] In comparative example 2 of the present application, the ratio of the outer diameter of the mixing tube body 12 to the inner diameter of the capillary 11 is 0.52, and the ratio of the inner diameter of the mixing tube body 12 to the inner diameter of the capillary 11 is 0.4;

[0061] Comparative Example 3

[0062] In comparative example 3 of the present application, the ratio of the outer diameter of the mixing tube body 12 to the inner diameter of the capillary tube 11 is 0.64, and the ratio of the inner diameter of the mixing tube body 12 to the inner diameter of the capillary tube 11 is 0.4;

[0063] Comparative Example 4

[0064] In comparative example 4 of the present application, the ratio of the outer diameter of the mixing tube body 12 to the inner diameter of the capillary 11 is 0.64, and the ratio of the inner diameter of the mixing tube body 12 to the inner diameter of the capillary 11 is 0.48;

[0065]

[0066]

[0067] By combining Examples 1-7 and the normal human red blood cell concentration as a reference, it can be roughly concluded that the red blood cell concentration in the venous blood taken from a healthy adult male should be 4-5x109 / L. Combining Examples 1-4 and Comparative Example 4, it can be seen that as the outer diameter of the mixing tube body 12 gradually increases, the red blood cell concentration gradually increases when only shaken three times, that is, the erythrocyte sedimentation rate phenomenon is most effective when the ratio of the outer diameter of the mixing tube body 12 to the inner diameter of the capillary 11 is 0.81.

[0068] In the process of further expanding the outer diameter of the mixing tube body 12, referring to Examples 5-8, the concentration of red blood cells gradually decreases. Considering that in the process of increasing the outer diameter of the mixing tube body 12, the gap between the outer wall of the mixing tube body 12 and the inner wall of the capillary 11 decreases, the fluidity of the blood sample decreases during the movement of the mixing tube body 12 in the capillary 11, and thus the shaking effect is reduced.

[0069] Therefore, based on Examples 1-8 and Comparative Examples 2-3, when the ratio of the outer diameter of the mixing tube body 12 to the inner diameter of the capillary 11 is between 0.73-1, the ESR can be effectively mixed, and when the ratio of the outer diameter of the mixing tube body 12 to the inner diameter of the capillary 11 is between 0.81, the mixing effect is best.

[0070] First of all, it should be noted that the fragmentation of red blood cells is a normal phenomenon in the human blood. Generally, the fragmentation rate of red blood cells in the human body ranges from 0.5% to 1.5%. Since it is impossible to completely exclude the number of normal broken red blood cells in the human body, the data on the red blood cell fragmentation rate obtained in this application includes the part of normal red blood cell fragmentation in the human body.

[0071] In combination with the red blood cell fragmentation rates of Example 3, Example 7, and Example 8, when the red blood cell concentration is above 3.5x109 / L, the red blood cell fragmentation rate is about 1.2-1.3. Taking these three sets of data as a comparison basis for Examples 1-8, when the ratio of the inner diameter of the mixing tube body 12 to the inner diameter of the capillary 11 is between 0.48-0.68, the red blood cell fragmentation rate is below 1.3%; and when the ratio of the inner diameter of the mixing tube body 12 to the inner diameter of the capillary 11 is lower than 0.48, the red blood cell fragmentation rate increases significantly; and when the ratio of the inner diameter of the mixing tube body 12 to the inner diameter of the capillary 11 is between 0.68-0.8, the red blood cell fragmentation rate is higher than 1.3%, indicating that within this inner diameter ratio range (0.68-0.8), in the process of mixing the erythrocyte sedimentation rate, the squeezing and fragmentation of red blood cells is more obvious.

[0072] To sum up, when the ratio of the outer diameter of the mixing tube body 12 to the inner diameter of the capillary 11 is between 0.73-1, and the ratio of the inner diameter of the mixing tube body 12 to the inner diameter of the capillary 11 is between 0.48-0.68, when the mixing tube body 12 mixes the blood sample in the blood collector, the mixing effect on the erythrocyte sedimentation rate and the protective effect on the red blood cells can be guaranteed, so that the effect of subsequent machine testing is the most accurate, and the mixing operation of the erythrocyte sedimentation rate is simple.

[0073] The following combination Figure 2-Figure 6 Disclosed is a production process of a mixing tube enclosed in a capillary tube 11, comprising the following steps:

[0074] S1, pretreatment, firstly, cleaning the oil stains on the surface of the stainless steel pipe by washing;

[0075] S2, rough grinding, move the stainless steel pipe into the polishing equipment, use mechanical grinding and physical polishing to perform preliminary grinding on the surface of the stainless steel pipe, at this time the outer surface of the stainless steel pipe reaches Ra20;

[0076] S3, pickling and electrolytic polishing, the initially polished stainless steel pipe is further moved into the pickling and electrolytic equipment, and the outer and inner surfaces of the stainless steel pipe are finely polished. At this time, the finish of the outer and inner surfaces of the stainless steel pipe reaches Ra10;

[0077] S4, surface cleaning and internal cleaning, moving the stainless steel pipe after pickling and electrolysis into the water washing and testing equipment to clean the polished stainless steel pipe and perform surface and internal finish testing of the stainless steel pipe;

[0078] S5, anticoagulation treatment of the stainless steel tube, cutting the cleaned and tested stainless steel tube into a specified size and immersing the cut stainless steel tube in a 1250U / mol heparin solution for anticoagulation treatment.

[0079] In order to ensure that the smoothness of the outer and inner surfaces of the stainless steel reaches Ra10 during the pickling and electrolytic polishing process, the pickling electrolytic equipment in S3 includes a pickling tank body 2, a clamping assembly 3 arranged in the pickling tank body 2 for clamping the stainless steel pipe, and a processing assembly 6 arranged in the pickling tank for processing the precipitate. The pickling tank is rectangular, and the two side walls of the pickling tank are respectively fixedly connected with a first electrode and a second electrode, and the first electrode and the second electrode correspond to the positive electrode and the negative electrode of the power supply respectively, that is, there is no mandatory regulation on the positive and negative of the first electrode and the second electrode.

[0080] Reference Figure 2 , Figure 3 as well as Figure 4 The clamping assembly 3 includes a rotating shaft 31 rotatably arranged on two opposite inner side walls of the pickling tank, a clamping block 32 detachably arranged on the rotating shaft 31, and a positioning member 34 for keeping the clamping block 32 and the rotating shaft 31 in a constant relative position. The rotating shaft 31 is provided with two groups, and the two groups of rotating shafts 31 are arranged oppositely. The clamping blocks 32 are also provided with two groups, and the two groups of clamping blocks 32 are arranged oppositely. The two groups of clamping blocks 32 are provided with a receiving groove 33 on the side away from each other. The receiving groove 33 is snap-fitted with the rotating shaft 31, and the end sides of the two groups of rotating shafts 31 close to each other are polygonal. In the present application, the end side of the rotating shaft 31 is rectangular, and the receiving groove 33 is also rectangular. In other embodiments, the rotating shaft 31 and the receiving groove 33 can also be other polygonal shapes, as long as the transmission rotation of the rotating shaft 31 and the clamping block 32 can be realized. The clamping block 32 is also provided with a positioning member 34 for keeping the rotating shaft 31 and the receiving groove 33 in a constant relative position.

[0081] At the same time, since the mixing tube body 12 needs blood to flow inside the mixing tube body 12 when it is used in a blood collector, it is necessary to ensure that the inner and outer walls of the mixing tube body 12 are also pickled and polished. Therefore, in order to achieve this function, a group of rotating shafts 31 are arranged in a hollow shape, and a connecting pipe 35 is fixedly connected to the outer wall of the pickling tank. One end of the connecting pipe 35 is connected to the pickling tank body 2, and the other end is connected to the rotating shaft 31. The connecting pipe 35 is also provided with a pressurizing member 351 for allowing the pickling liquid in the pickling tank to flow into the connecting pipe 35. In this application, the pressurizing member 351 is in the form of a water pump, and a first connecting port 36 is provided on the clamping block 32 adapted to the rotating shaft 31. When the rotating shaft 31 is clamped in the accommodating groove 33, the rotating shaft 31 corresponds to the first connecting port 36 at this time, and the clamping block 32 A connecting channel 37 is provided inside, and a plurality of limiting grooves 38 are provided on the side where the two clamping blocks 32 are close to each other. The connecting channel 37 connects the first connecting port 36 with the plurality of limiting grooves 38. A tightening ring 39 is fixedly embedded in the limiting groove 38. The tightening ring 39 is made of rubber and is kept in close contact with the outer wall of the stainless steel pipe. A discharge port 381 connected to the limiting groove 38 is provided on the other set of clamping blocks 32; thus, during the entire pickling process, the pickling liquid flows from the pickling tank to the connecting pipe 35 under the action of the water pump, and flows from the limiting groove 38 to the stainless steel pipe. Due to the conductive properties of the stainless steel pipe itself, it can not only realize the pickling and polishing of the inner wall of the stainless steel pipe, but also reduce the blockage of the inner wall of the stainless steel pipe, thereby facilitating the subsequent use of the stainless steel pipe after being cut into the mixing pipe body 12.

[0082] Reference Figure 3 The positioning member 34 includes a positioning block 341 arranged on the clamping block 32, and positioning grooves 342 are opened on the two inner side walls opposite to the accommodating groove 33. The positioning block 341 is slidably arranged in the positioning groove 342, and the sliding direction of the positioning block 341 is perpendicular to the sliding direction of the rotating shaft 31 sliding into the accommodating groove 33. One end of the positioning block 341 close to the inner bottom wall of the positioning groove 342 is fixedly connected with a positioning spring 343, and the other end of the positioning spring 343 is fixedly connected to the inner bottom wall of the positioning groove 342. The side of the positioning block 341 close to the inner bottom wall of the accommodating groove 33 is movably fitted and pressed against the side of the rotating shaft 31 away from the inner bottom wall of the accommodating groove 33.

[0083] In order to facilitate the automatic limiting clamping of the rotating shaft 31 by the positioning block 341 after the rotating shaft 31 slides into the receiving groove 33, the side of the positioning block 341 away from the inner bottom wall of the receiving groove 33 is inclined, and the inclined side of the positioning block 341 is movably fitted and pressed against the side of the rotating shaft 31 away from the inner bottom wall of the receiving groove 33.

[0084] Furthermore, since the positioning block 341 is elastically arranged in the positioning groove 342, in order to reduce the loosening of the rotating shaft 31 by the positioning block 341 under the action of centrifugal force when the clamping block 32 rotates, thereby improving the stability of pickling, the clamping block 32 is also provided with a limiting component 4 for limiting the position of the positioning block 341. The limiting component 4 includes a limiting block 41 slidably arranged on the clamping block 32, and a limiting hole 42 for inserting the limiting block 41 is opened on the positioning block 341. The sliding direction is perpendicular to the sliding direction of the positioning block 341. A movable groove 43 is opened in the clamping block 32. The opening direction of the movable groove 43 is perpendicular to the opening direction of the positioning groove 342. The limit block 41 is slidably set in the movable groove 43, and a limit spring 44 is provided between the limit block 41 and the inner bottom wall of the movable groove 43. One end of the limit spring 44 is fixed to one end of the limit block 41 close to the inner bottom wall of the movable groove 43, and the other end of the limit spring 44 is fixed to the inner bottom wall of the movable groove 43.

[0085] During the pickling process, the pickling liquid in the pickling tank will have uneven concentration as the reaction proceeds. At this time, in order to ensure the uniformity of pickling of the stainless steel pipes between the two groups of clamping blocks 32, the rotating shaft 31 drives multiple stainless steel pipes to rotate. Since the diameter of the stainless steel pipe in this application is relatively thin, the stainless steel pipe is prone to twisting during the rotation of the two groups of clamping blocks 32, thereby affecting the size of the stainless steel pipe when it is subsequently used as a mixing tube. Therefore, in order to solve this problem, a fixed rod 45 is fixedly connected between the two groups of clamping blocks 32, and the two ends of the fixed rod 45 are respectively fixedly connected to the two groups of clamping blocks 32.

[0086] At the same time, during the pickling electrolysis process, some reactants will precipitate and flocculate on the outer surface of the stainless steel tube. In order to reduce the reactants precipitated on the surface of the stainless steel tube after being taken out of the pickling tank to form oxides and adhere to the surface of the stainless steel tube again, a wiping component 5 for wiping the surface of the stainless steel tube is slidably provided on the fixed rod 45. The sliding direction of the wiping component 5 is consistent with the length direction of the fixed rod 45, so that the surface of the stainless steel tube is smooth during the entire pickling and polishing process.

[0087] Reference Figure 4The middle part of the fixed rod 45 is hollow, and the wiping assembly 5 includes a rotating screw rod 52 rotatably arranged in the middle part of the fixed rod 45 and a sliding block 51 threadedly assembled on the rotating screw rod 52. One end of the rotating screw rod 52 maintains a constant relative position with the inner wall of the pickling tank, and a clearance groove is provided on the outer peripheral wall of the fixed rod 45. The sliding block 51 is slidably adapted to the clearance groove, so that the fixed rod 45 drives the sliding block 51 to move along the length direction of the fixed rod 45 during the rotation of the clamping block 32. Sliding, the wiping assembly 5 also includes a wiping block 53 connected to the sliding block 51, a wiping groove 54 is provided on the wiping block 53, the outer peripheral wall of the wiping groove 54 is provided with an opening for inserting the stainless steel tube, and a plurality of wiping sponges 55 are fixedly bonded in the wiping groove 54, the wiping sponges 55 are in contact with the outer peripheral wall of the stainless steel tube, a plurality of groups of wiping blocks 53 are provided, and the plurality of groups of wiping blocks 53 are arranged at intervals along the outer peripheral side of the fixed rod 45, and the plurality of groups of wiping blocks 53 correspond one by one to the plurality of groups of stainless steel tubes.

[0088] In order to facilitate the pickling of stainless steel pipes and the removal of stainless steel pipes after batch pickling, the clamping block 32 is detachably arranged on the rotating shaft 31. At this time, in order to achieve the rotation of the stainless steel pipe without interference with the rotation of the rotating screw 52, ​​one end of the rotating screw 52 is rotatably connected to the inner wall of the pickling tank, and the rotating axis of the rotating screw 52 is horizontal, and the sliding block 51 slidably arranged on the fixed rod 45 is located in the inner part of the fixed rod 45 and is annular.

[0089] In order to achieve efficient pickling and polishing of multiple batches of stainless steel pipes, each group of clamping blocks 32 includes a plurality of clamping blocks 32 spaced apart along the width direction of the pickling tank. In the present application, each group of clamping blocks 32 includes three clamping blocks 32 spaced apart along the width direction of the pickling tank. Similarly, in the present application, each group of rotating shafts 31 includes three rotating shafts 31 corresponding to the clamping blocks 32, and a synchronous gear 311 is coaxially fixed on each rotating shaft 31, and adjacent synchronous gears 311 are meshed with each other.

[0090] Also refer to Figure 5 The processing component 6 includes a filter plate 61 arranged in the pickling tank, and the filter plate 61 is densely provided with filter holes 62, and the filter plate 61 is provided with collection boxes 63 on both sides of the filter plate 61 along the length direction of the fixed rod 45. The synchronization component also includes a scraper 64 slidably arranged in the pickling tank and an adjusting member for slidingly adjusting the scraper 64. The scraper 64 is in contact with the upper surface of the filter plate 61. The adjusting member also includes a synchronous screw 65 rotatably arranged in the pickling tank. The scraper 64 is threadedly assembled on the synchronous screw 65. The synchronous screw 65 is also provided with a driven gear 66, and the driven gear 66 is meshed with the driven gear.

[0091] During the entire pickling process, the scraper 64 and the slider move synchronously, so that pickling, dust removal of the stainless steel pipe and cleaning of the sediment on the scraper 64 can be carried out simultaneously, saving power source and improving the pickling and polishing efficiency of the stainless steel pipe.

[0092] The production process of a mixing tube for mixing erythrocyte sedimentation enclosed in a capillary tube 11 according to an embodiment of the present application is as follows: first, the technician takes the clamping block 32 out of the pickling tank. When taking it out, the clamping block 32 drives the rotating screw 52 to rotate until the rotating screw 52 rotates to a vertical position, thereby taking out the clamping block 32. At this time, the technician inserts the stainless steel tube to be pickled into the limiting groove 38. At this time, the stainless steel tube is stably clamped under the tight action of the rubber ring. After the stainless steel tube is stably installed, the technician moves the clamping block 32 into the pickling tank to move the rotating shaft 31. The rotating shaft 31 then presses against the positioning block 341 to make the positioning block 341 sink into the receiving groove 33. The rotating shaft 31 continues to move into the receiving groove 33 until the positioning block 341 is located on the side of the rotating shaft 31 away from the inner bottom wall of the receiving groove 33. At this time, the positioning block 341 rebounds under the action of the elastic restoring force to limit the rotating shaft 31, so that the clamping block 32 is driven to rotate when the rotating shaft 31 rotates, so that the stainless steel pipe rotates as the pickling proceeds, so as to stir the pickling solution and achieve uniform pickling and polishing of multiple stainless steel pipes.

[0093] At the same time, the small water pump set at this time transports the pickling liquid in the pickling tank to the inner wall of the stainless steel pipe, thereby realizing the pickling of the inner surface of the stainless steel pipe and improving the smoothness of the inner and outer surfaces of the stainless steel pipe;

[0094] At the same time, when the clamping block 32 rotates, since the rotating screw 52 is rotatably connected to the inner wall of the pickling tank, the rotating screw 52 does not rotate when the clamping block 32 rotates, thereby realizing the sliding block 51 sliding along the length direction of the rotating screw 52, ​​driving multiple wiping blocks 53 to wipe and remove scale on multiple stainless steel pipes.

[0095] The above are all preferred embodiments of the present application, and the protection scope of the present application is not limited thereto. Therefore, any equivalent changes made according to the structure, shape, and principle of the present application should be included in the protection scope of the present application.

Claims

1. A mixing tube for mixing erythrocyte sedimentation enclosed in a capillary tube, characterized in that: The mixing tube body (12) is slidably disposed in the capillary (11), the ratio of the outer diameter of the mixing tube body (12) to the outer diameter of the capillary (11) is 0.48-0.68, and the ratio of the inner diameter of the mixing tube body (12) to the inner diameter of the capillary (11) is 0.46-0.69; The outer diameter of the capillary (11) is 1.9-2.3 mm, the inner diameter of the capillary (11) is 1.3-1.5 mm, the outer diameter of the mixing tube body (12) is 1.1-1.3 mm, and the inner diameter of the mixing tube body (12) is 0.7-0.9 mm; The mixing tube body (12) is made of stainless steel, and the magnet pulls the mixing tube body (12) to move in the capillary (11).

2. The mixing tube for mixing erythrocyte sedimentation in a capillary tube according to claim 1, characterized in that: The surface finish of the mixing tube body (12) is Ra10, and the inner wall of the capillary tube (11) is anticoagulant treated. The anticoagulant used in the anticoagulant treatment of the capillary tube (11) is a heparin solution containing 10-50 units per milliliter of physiological saline.

3. A production process of a mixing tube for mixing and erythrocyte sedimentation rate enclosed in a capillary tube, applied to the mixing tube for mixing and erythrocyte sedimentation rate enclosed in a capillary tube (11) as claimed in any one of claims 1 to 2, characterized in that: The steps include: S1, pretreatment, firstly, cleaning the oil stains on the surface of the stainless steel pipe by washing; S2, rough grinding, move the stainless steel pipe into the polishing equipment, use mechanical grinding and physical polishing to perform preliminary grinding on the surface of the stainless steel pipe, at this time the outer surface of the stainless steel pipe reaches Ra20; S3, pickling and electrolytic polishing, the initially polished stainless steel pipe is further moved into the pickling and electrolytic equipment, and the outer and inner surfaces of the stainless steel pipe are finely polished. At this time, the finish of the outer and inner surfaces of the stainless steel pipe reaches Ra10; S4, surface cleaning and internal cleaning, moving the stainless steel pipe after pickling and electrolysis into the water washing and testing equipment to clean the polished stainless steel pipe and perform surface and internal finish testing of the stainless steel pipe; S5, anticoagulation treatment of the stainless steel tube, cutting the cleaned and tested stainless steel tube into a specified size and immersing the cut stainless steel tube in a 1250U / mol heparin solution for anticoagulation treatment.

4. The process for producing a mixing tube for mixing erythrocyte sedimentation in a capillary tube according to claim 3, characterized in that: The pickling electrolysis equipment in step S3 comprises a pickling tank body (2), a clamping component (3) arranged in the pickling tank body (2) for clamping the stainless steel pipe, and a processing component (6) arranged in the pickling tank for processing the precipitate.

5. A blood sampling device, comprising a mixing tube for mixing erythrocyte sedimentation enclosed in a capillary tube as claimed in any one of claims 1 to 2, characterized in that: The invention comprises a shell (1), a U-shaped capillary tube arranged in the shell (1), a Luer head arranged at the front end of the shell (1) and connected to one end of the capillary tube (11), and a sealing interface (14) arranged at the front end of the shell (1) and connected to the other end of the capillary tube (11), wherein a sealing head is detachably arranged at the sealing interface (14), two mixing tube bodies (12) are arranged in the capillary tube (11), and the mixing tube bodies (12) are slidably arranged in the capillary tube (11), and a hemostatic element (15) is also arranged in the shell (1).

6. A blood sampling device according to claim 5, characterized in that: A sealing piece is provided in the Luer head, wherein the sealing piece is a rubber sealing ring (17) provided in the Luer head, the rubber sealing ring (17) is hollow, and the inner diameter of the rubber sealing ring (17) is smaller than the diameter of the end side of the capillary tube (11).

7. A blood sampling device according to claim 6, characterized in that: The diameter of the sampling probe of the sampling instrument is 0.9 mm-1.3 mm, so the inner diameter of the rubber sealing ring (17) is between 0.8 mm and 1.2 mm, and the inner peripheral wall of the rubber sealing ring (17) is movably pressed against the outer peripheral wall of the sampling probe.

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