Lung nourishing composition and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine, in particular to a lung nourishing composition and a preparation method thereof; the lung nourishing composition comprises the following raw materials in parts by weight: 13 parts of pinellia tuber, 100 parts of fresh fruits without pulp of immature bitter orange, 7 parts of poria, 7 parts of liquorice, 37 parts of polypeptide powder and 37-55 parts of honey; the compatibility of pinellia tuber, immature bitter orange, poria and liquorice has the effects of harmonizing the stomach and promoting sleep, thereby improving human body functions and indirectly helping the lungs to heal; in addition, whey protein polypeptide powder and wolfberry polypeptide powder are added, the whey protein polypeptide powder is used as an orthopedic agent and a water-absorbing material on the one hand, and as a medicinal ingredient for improving human blood circulation on the other hand, and the wolfberry polypeptide powder has a liver-protecting effect; the Chinese and Western medicines are combined to improve the therapeutic effect.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a lung nourishing composition and a preparation method thereof. Background Art

[0002] It takes a long time for the human body to heal itself after the lungs are damaged due to respiratory infections and other reasons. It is well known that the active ingredients of drugs are difficult to reach the lungs, so long-term medication is required for lung diseases or lung damage. Some companies have developed drugs or foods such as Bufei Pills and Yangfei Soup to enhance lung immunity and accelerate lung recovery. At present, this type of product mainly improves the treatment effect from the following aspects: 1. Inhibit bronchial smooth muscle and relieve cough symptoms; 2. Expectorant; 3. Kill bacteria and reduce inflammation.

[0003] The shortcomings of the existing technology are that when the lungs are damaged, the inevitable symptoms such as coughing and difficulty breathing are likely to cause loss of appetite and lack of sleep, which in turn affects body functions and overall immunity. The effect of treating only lung symptoms is limited. There is an urgent need for a composition that nourishes the lungs, improves appetite and helps sleep.

[0004] In addition, the existing Bufei Pills are generally packaged in bottles (with dozens of Bufei Pills in the packaging bottle). After opening the package and taking them for a certain period of time, the surfaces of the remaining Bufei Pills absorb moisture in the air, and adjacent Bufei Pills will stick together, affecting their use. Summary of the invention

[0005] In view of the deficiencies in the prior art, one of the purposes of the present invention is to provide a lung nourishing composition, which has the effects of improving appetite, helping sleep, and resolving phlegm and relieving cough.

[0006] The second object of the present invention is to provide a method for preparing a lung nourishing composition.

[0007] One of the purposes of the present invention is achieved through the following technical solutions:

[0008] A lung nourishing composition comprising the following raw materials in parts by weight:

[0009] 13 parts of pinellia tuber, 100 parts of fresh fruit of immature bitter orange without pulp, 7 parts of tuckahoe, 7 parts of liquorice, 37 parts of polypeptide powder and 37-55 parts of honey.

[0010] Preferably, the pinellia tuber, poria cocos and liquorice are all crushed into particles of less than or equal to 60 meshes, which is convenient for processing and human body absorption.

[0011] Preferably, the polypeptide powder includes whey protein polypeptide powder and wolfberry polypeptide powder. The mass ratio of whey protein polypeptide powder in the polypeptide powder is 50%-80%. The whey protein polypeptide powder is first used as an orthopedic material to absorb the water overflowed from the fresh fruit of the immature bitter orange and to bond other materials so that the composition is easy to shape. In addition, the whey protein polypeptide powder also promotes blood circulation and accelerates the arrival of various drug ingredients in the lungs. The role of wolfberry polypeptide powder here is mainly as a liver-protecting drug for long-term human medication to reduce transaminase.

[0012] The therapeutic principle of this composition:

[0013] Pinellia, Citrus aurantium, Poria and Licorice constitute a combination of Chinese medicines that soothe the stomach, relieve cough and reduce inflammation. Among them, Pinellia is the main medicine, which mainly dries dampness and resolves phlegm, relieves adverse reactions and stops vomiting; Citrus aurantium is the assistant medicine, which mainly breaks up qi and eliminates accumulation, resolves phlegm and relieves lumps; Poria and Licorice are auxiliary medicines, Poria is used to calm the nerves, and Licorice is used to neutralize the medicinal properties. After taking it, the human body first boosts appetite to avoid loss of appetite caused by long-term use of the medicine; then it calms the nerves and helps sleep, further enhancing the body's immunity; finally, it treats lung lesions; the above-mentioned drug effects are combined to accelerate lung recovery.

[0014] The second object of the present invention is achieved by the following technical solutions:

[0015] A method for preparing a lung nourishing composition comprises the following steps:

[0016] Step 1, weigh the raw materials;

[0017] Step 2: Remove the pulp of fresh Citrus aurantium and beat into pulp, add whey protein polypeptide powder into the pulp and stir into a paste; here, whey protein polypeptide powder should be added first instead of wolfberry polypeptide powder, because the wolfberry polypeptide powder sold on the market has better water solubility, so it is not easy to form a paste, which is not conducive to the formation of the composition;

[0018] Step 3, add pinellia tuber, poria cocos and liquorice to the slurry and stir evenly;

[0019] Step 4, add wolfberry polypeptide powder to the slurry. At this time, there is less unabsorbed water in the slurry. Adding wolfberry polypeptide powder with better water solubility can quickly absorb the remaining small amount of water, and then add honey and stir well to obtain the ointment;

[0020] Step 5: Spread the ointment to 2-5 mm;

[0021] Step 6, place the ointment under red and blue light, and stop irradiating when the water content of the ointment is less than 40% (inclusive);

[0022] Step 7, feeding the ointment into an extruder and extruding, granulating, and rolling into pills to obtain honey pills;

[0023] Step 8: Place the honey pills under a UV lamp for 30 minutes, turning them over every 2 minutes to ensure even irradiation.

[0024] Preferably, the red and blue light parameters are as follows:

[0025] Working voltage 220V, rated power 500W, red light wavelength 633nm, blue light wavelength 417nm.

[0026] Preferably, the diameter of the honey pills is 1.6-3.4 mm. If the diameter is too large, it is not easy to dry, and if the diameter is too small, the initial moisture content of each honey pill will vary greatly.

[0027] Preferably, the parameters of the ultraviolet lamp are as follows:

[0028] Working voltage 220V, rated power 500W, purple light wavelength 365nm.

[0029] Preferably, the surface temperature of the ointment is controlled to be less than 60° C. during the irradiation under the red and blue light, and the surface temperature of the honey pill is controlled to be less than 60° C. during the irradiation under the ultraviolet light. Experiments have shown that excessively high temperatures can easily lead to a decrease in the efficacy of the drug.

[0030] Preferably, step 8 further comprises testing the water content of the honey pills, and air-drying the honey pills when the water content is higher than 25% (inclusive) until the water content is lower than 25%. As is known, honey pills contain a lot of sugar, and if the water content is too high, bacteria are very likely to grow.

[0031] The beneficial effects of the present invention are as follows: the compatibility of pinellia tuber, immature bitter orange, poria and liquorice has the effects of soothing the stomach and promoting sleep, thereby improving human functions and indirectly helping the lungs to heal; in addition, whey protein polypeptide powder and wolfberry polypeptide powder are added, the whey protein polypeptide powder is used as an orthopedic agent and water-absorbing material on the one hand, and as a medicinal ingredient for improving human blood circulation on the other hand, the wolfberry polypeptide powder has a liver-protecting effect; the combination of Chinese and Western medicine improves the therapeutic effect. DETAILED DESCRIPTION

[0032] The following is further described in conjunction with specific implementation methods:

[0033] Example 1

[0034] Weigh the raw materials according to weight:

[0035] 13 parts of pinellia tuber, 100 parts of fresh fruits without pulp of immature bitter orange, 7 parts of tuckahoe, 7 parts of liquorice, 37 parts of polypeptide powder and 38 parts of honey. The pinellia tuber, tuckahoe and liquorice are all crushed into particles less than or equal to 60 mesh. The polypeptide powder includes whey protein polypeptide powder and wolfberry polypeptide powder. The mass ratio of whey protein polypeptide powder in the polypeptide powder is 55%.

[0036] Remove the pulp from the fresh fruit of Citrus aurantium and blend it into pulp. Add whey protein polypeptide powder into the pulp and stir into a paste.

[0037] Add pinellia, poria and liquorice to the slurry and stir well.

[0038] Add wolfberry polypeptide powder to the paste, and then add honey and stir well to obtain an ointment.

[0039] Spread the ointment to 2 mm.

[0040] Place the ointment under a red and blue light lamp and irradiate it. Stop irradiation when the water content of the ointment is less than 40% (inclusive). The parameters of the red and blue light lamp are as follows: working voltage 220V, rated power 500W, red light wavelength 633nm, blue light wavelength 417nm. During the irradiation under the red and blue light lamp, the surface temperature of the ointment is controlled to be less than 60°C. The control method adopted in this embodiment is: when it is detected that the surface temperature of the ointment is higher than 55°C, the red and blue light lamp is temporarily turned off, and it is turned on again when the surface temperature of the ointment is lower than 50°C until the irradiation is completed.

[0041] The ointment is fed into an extruder and extruded, granulated, and rolled into balls to obtain honey balls with a diameter of 2.0 mm.

[0042] Place the honey pills under a purple light lamp for 30 minutes, turning them over every 2 minutes. The parameters of the purple light lamp are as follows: working voltage 220V, rated power 500W, purple light wavelength 365nm. During the irradiation under the purple light, the surface temperature of the honey pills is controlled to be less than 60°C. The control method adopted in this embodiment is: when it is detected that the surface temperature of the honey pills is higher than 55°C, the purple light lamp is temporarily turned off, and it is turned on again when the surface temperature of the honey pills is lower than 50°C until the irradiation is completed.

[0043] The water content of the honey pills is tested. When the water content of the honey pills is higher than 25% (inclusive), they are air-dried until the water content is lower than 25%.

[0044] Example 2

[0045] Weigh the raw materials according to weight:

[0046] 13 parts of pinellia tuber, 100 parts of fresh fruits without pulp of immature bitter orange, 7 parts of tuckahoe, 7 parts of liquorice, 37 parts of polypeptide powder and 50 parts of honey. The pinellia tuber, tuckahoe and liquorice are all crushed into particles less than or equal to 60 mesh. The polypeptide powder includes whey protein polypeptide powder and wolfberry polypeptide powder. The mass ratio of whey protein polypeptide powder in the polypeptide powder is 75%.

[0047] Remove the pulp from the fresh fruit of Citrus aurantium and blend it into pulp. Add whey protein polypeptide powder into the pulp and stir into a paste.

[0048] Add pinellia, poria and liquorice to the slurry and stir well.

[0049] Add wolfberry polypeptide powder to the paste, and then add honey and stir well to obtain an ointment.

[0050] Spread the ointment to 4 mm.

[0051] The ointment is placed under a red and blue light lamp and irradiated. When the water content of the ointment is less than 40% (inclusive), the irradiation is stopped. The parameters of the red and blue light lamp are as follows: working voltage 220V, rated power 500W, red light wavelength 633nm, blue light wavelength 417nm. During the irradiation under the red and blue light lamp, the surface temperature of the ointment is controlled to be less than 60°C.

[0052] The ointment is fed into an extruder and extruded, granulated, and rolled into balls to obtain honey balls with a diameter of 3.1 mm.

[0053] The honey pills were placed under a violet lamp for 30 minutes, during which the honey pills were turned over every 2 minutes. The parameters of the violet lamp were as follows: working voltage 220V, rated power 500W, violet wavelength 365nm. During the irradiation under the violet lamp, the surface temperature of the honey pills was controlled to be less than 60°C.

[0054] The water content of the honey pills is tested. When the water content of the honey pills is higher than 25% (inclusive), they are air-dried until the water content is lower than 25%.

[0055] Example 3

[0056] Weigh the raw materials according to weight:

[0057] 13 parts of pinellia tuber, 100 parts of fresh fruits without pulp of immature bitter orange, 7 parts of tuckahoe, 7 parts of liquorice, 37 parts of polypeptide powder and 45% of honey. The pinellia tuber, tuckahoe and liquorice are all crushed into particles less than or equal to 60 mesh. The polypeptide powder includes whey protein polypeptide powder and wolfberry polypeptide powder. The mass ratio of whey protein polypeptide powder in the polypeptide powder is 65%.

[0058] Remove the pulp from the fresh fruit of Citrus aurantium and blend it into pulp. Add whey protein polypeptide powder into the pulp and stir into a paste.

[0059] Add pinellia, poria and liquorice to the slurry and stir well.

[0060] Add wolfberry polypeptide powder to the paste, and then add honey and stir well to obtain an ointment.

[0061] Spread the ointment to 4 mm.

[0062] The ointment is placed under a red and blue light lamp and irradiated. When the water content of the ointment is less than 40% (inclusive), the irradiation is stopped. The parameters of the red and blue light lamp are as follows: working voltage 220V, rated power 500W, red light wavelength 633nm, blue light wavelength 417nm. During the irradiation under the red and blue light lamp, the surface temperature of the ointment is controlled to be less than 60°C.

[0063] The ointment is fed into an extruder and extruded, granulated, and rolled into balls to obtain honey balls with a diameter of 2.6 mm.

[0064] The honey pills were placed under a violet lamp for 30 minutes, during which the honey pills were turned over every 2 minutes. The parameters of the violet lamp were as follows: working voltage 220V, rated power 500W, violet wavelength 365nm. During the irradiation under the violet lamp, the surface temperature of the honey pills was controlled to be less than 60°C.

[0065] The water content of the honey pills is tested. When the water content of the honey pills is higher than 25% (inclusive), they are air-dried until the water content is lower than 25%.

[0066] Comparative Example 1

[0067] Buy lung-boosting pills (brand: Yang Wuji) from the market.

[0068] Comparative Example 2

[0069] When the red and blue light is irradiated, the surface temperature of the plaster is controlled at 60-65° C. The remaining steps are the same as those in Example 3.

[0070] Comparative Example 3

[0071] When irradiated with ultraviolet light, the surface temperature of the honey pills was controlled at 60-65° C. The remaining steps were the same as those in Example 3.

[0072] Comparative Example 4

[0073] The order of using the red and blue light lamps and the purple light lamps is changed. The remaining steps are the same as those in Example 3.

[0074] Comparative Example 5

[0075] The red and blue light lamps and the purple light lamps are replaced with fluorescent lamps of the same power. The remaining steps are the same as those in Example 3.

[0076] Adhesion test

[0077] 1. Experimental purpose: To verify that the honey pills obtained by the present invention have anti-adhesion effect.

[0078] 2. Experimental method: Examples 1-3 and Comparative Examples 1-5 were placed in plastic bottles at a specification of 50 pills / bottle, respectively, and placed under the conditions of 25°C and 75% relative humidity. The bottle cap was unscrewed once a day, and one honey pill or lung-boosting pill was taken out. The bottle cap was closed within 1 minute after opening, and the stickiness of the remaining 25 honey pills or lung-boosting pills was tested after 25 days. Specifically, the honey pill or lung-boosting pill was placed in the center of A8 paper for 5 minutes, and then the honey pill or lung-boosting pill was lifted with tweezers to observe whether the honey pill or lung-boosting pill could stick to and lift the paper (so that the paper was completely off the table), and the number of honey pills or lung-boosting pills in each group that could lift the paper was counted.

[0079] 3. Experimental results, see Table 2.

[0080] Table 2 Number of times paper is brought up

[0081] Group Number of belts Example 1 0 Example 2 0 Example 3 0 Comparative Example 1 18 Comparative Example 2 0 Comparative Example 3 0 Comparative Example 4 21 Comparative Example 5 23

[0082] An unexpected discovery: The present invention uses a UV lamp to treat the surface of the honey pills, so that the honey pills are not easy to absorb water during storage, thereby avoiding adhesion between adjacent honey pills, making it easier for patients to take out the honey pills from the packaging bottle, and also making it cleaner and more hygienic.

[0083] Active ingredient detection experiment

[0084] 1. Experimental purpose: To verify that the honey pills processed by the present invention can better retain the naringin component in the medicinal materials than the traditional honey pill production process.

[0085] 2. Experimental method: 1 g of the honey pills obtained in Example 3 and Comparative Examples 2-5 were taken as samples, and high performance liquid chromatography (HPLC) was used. The specific experimental parameters were: the chromatographic column was an OMNI-C18 column (4.6 mm × 250 mm, 5 μm), the mobile phase was acetonitrile-0.1% phosphoric acid (18: 82), the flow rate was 1.0 mL min-1, the column temperature was 30°C, and the detection wavelength was 284 nm. The experiment was repeated 3 times, and the average values ​​were recorded in Table 3.

[0086] 3. Experimental results, see Table 3.

[0087] Table 3 Statistics of naringin content

[0088] Group Average content of naringin (mg / g) Example 3 2.21 Comparative Example 2 1.79 Comparative Example 3 1.74 Comparative Example 4 1.89 Comparative Example 5 1.75

[0089] It can be seen from Table 3 that after the treatment of the present invention, the content of naringin in the honey pills obtained in Example 3 is significantly higher than that in the other groups. Since the five groups have the same ingredients and the only difference is the treatment process, it can be inferred without a doubt that the treatment steps of the present invention have an effect of increasing the content of naringin in the product.

[0090] The above embodiments and descriptions are only for illustrating the principles and best embodiments of the present invention. Without departing from the spirit and scope of the present invention, the present invention may be subject to various changes and improvements, all of which fall within the scope of the present invention to be protected.

Claims

1. A method for preparing a lung nourishing composition, characterized in that: The following steps are involved: Step 1, weigh the raw materials; Step 2: Remove the pulp of the fresh fruit of Citrus aurantium and beat it into pulp, add whey protein polypeptide powder into the pulp and stir into a paste; Step 3, add pinellia tuber, poria cocos and liquorice to the slurry and stir evenly; Step 4, add wolfberry polypeptide powder to the slurry, and then add honey and stir well to obtain an ointment; Step 5: Spread the ointment to 2-5 mm; Step 6, place the ointment under red and blue light, and stop irradiating when the water content of the ointment is less than 40%; Step 7, feeding the ointment into an extruder and extruding, granulating, and rolling into pills to obtain honey pills; Step 8: Place the honey pills under a UV light for 30 minutes, turning them over every 2 minutes to ensure uniform irradiation; The lung nourishing composition comprises the following raw materials in parts by weight: 13 parts of pinellia tuber, 100 parts of fresh fruit of immature bitter orange without pulp, 7 parts of tuckahoe, 7 parts of liquorice, 37 parts of polypeptide powder and 37-55 parts of honey; The pinellia tuber, poria cocos and liquorice are all crushed into particles of less than or equal to 60 mesh; The polypeptide powder includes whey protein polypeptide powder and wolfberry polypeptide powder; The mass ratio of the whey protein polypeptide powder in the polypeptide powder is 50%-80%.

2. The method for preparing the lung nourishing composition according to claim 1, characterized in that: The red and blue light parameters are as follows: Working voltage 220V, rated power 500W, red light wavelength 633nm, blue light wavelength 417nm.

3. The method for preparing the lung nourishing composition according to claim 1, characterized in that: The diameter of the honey pills is 1.6-3.4 mm.

4. The method for preparing the lung nourishing composition according to claim 1, characterized in that: The parameters of the ultraviolet lamp are as follows: Working voltage 220V, rated power 500W, purple light wavelength 365nm.

5. The method for preparing the lung nourishing composition according to claim 1, characterized in that: During the irradiation under the red and blue light, the surface temperature of the ointment is controlled to be less than 60°C, and during the irradiation under the ultraviolet light, the surface temperature of the honey pills is controlled to be less than 60°C.