Medical medium-chain fatty acid ester and method for preparing the same

Abstract

The application discloses a medical gauze and a preparation method thereof, and belongs to the technical field of health supplies. The preparation method of the medical gauze comprises the following steps: taking sodium carbonate solution to adjust the pH value to 8-10, heating in a water bath to 30-50 DEG C, and then putting the cut and tailored degreased polyester cotton cloth for treatment; dissolving polyvinyl alcohol in water, adding high water-absorbing resin for stirring to obtain a water-absorbing agent; heating the water-absorbing agent to 40-60 DEG C, putting the pretreated polyester cotton cloth for soaking to obtain the polyester cotton cloth; uniformly mixing 20-40 parts by weight of silica sol, 100-300 parts by weight of modified filler, 12-18 parts by weight of a coupling agent and 0.03-0.1 part by weight of a catalyst, pouring into a mold, smoothing the surface, and standing to obtain a silica gel pad; sewing a magic tape hook face on the outer periphery of the polyester cotton cloth to obtain a skin-friendly layer, adhering a magic tape hair face on the outer periphery of the silica gel pad to obtain a compression-resistant layer, and pasting the skin-friendly layer on the top of the compression-resistant layer through the magic tape hook face and the magic tape hair face to obtain the medical gauze. The medical gauze has excellent compression resistance and can relieve the discomfort of patients who have been in bed for a long time.

Description

Technical Field

[0001] The present application relates to a medical midriff and a preparation method thereof, belonging to the technical field of sanitary products. Background Art

[0002] Medical midsheets are special sheets placed over the bed base and sheets of hospital beds. They prevent patient waste from contaminating the underlying sheet, thus maintaining a clean bed unit. Currently, there are two main types of medical midsheets in common use: traditional medical midsheets, typically made from a single layer of pure cotton cloth; and a non-woven fabric with a barrier effect. Both types of midsheets protect the bed sheet from contamination, but their functions are limited and, as disposable items, they are more expensive.

[0003] Chinese invention patent CN114344017A discloses a medical midline singlet and its preparation method, which includes: a two-layer structure of a waterproof layer and a skin-friendly layer, wherein the skin-friendly layer is detachably fixed on the waterproof layer; the waterproof layer comprises a polytetrafluoroethylene microporous membrane. The medical midline singlet is breathable and dry, waterproof and antifouling, has good antibacterial effect, can be used for a long time, and can be disassembled, washed, disinfected and reused. However, for patients who have been bedridden for a long time due to illness, due to the continuous pressure on local parts of the body, the blood flow in the pressured parts is not smooth, which can easily lead to pressure injuries around the wound, also known as "bedsores". The above-mentioned medical midline singlet has limited pressure resistance and flexibility, so it is difficult to provide a comfortable experience for patients who have been bedridden for a long time. Summary of the Invention

[0004] In order to solve the above problems, a medical midline singlet and a preparation method thereof are provided, wherein the skin-friendly layer is not only soft and tear-resistant, but also has high water absorption and good biodegradability; the pressure-resistant layer is breathable but does not absorb water, and at the same time has excellent antibacterial and pressure-resistant properties, which can alleviate the discomfort caused to patients who are bedridden for a long time; by replacing the skin-friendly layer, the pressure-resistant layer can be reused, which is economical and environmentally friendly and has broad application prospects.

[0005] The present invention provides the following technical solutions:

[0006] According to one aspect of the present application, a method for preparing a medical singlet is provided, comprising the following steps:

[0007] Step 1: Take a sodium percarbonate solution with a concentration of 0.05-0.2 g / L, adjust the pH to 8-10, heat it in a water bath to 30-50° C., put it into the cut degreased polyester-cotton cloth and treat it for 1-2 hours, take it out and wash it to neutrality, and dry it to obtain the pretreated polyester-cotton cloth;

[0008] Step 2: Dissolve polyvinyl alcohol in water, add super absorbent resin and stir evenly to obtain a water absorbent with a concentration of 0.05-0.1 g / L; heat the water absorbent to 40-60°C, put it into the pretreated polyester-cotton cloth and soak it for 3-5 minutes, remove and remove excess water absorbent, and dry it to obtain polyester-cotton cloth;

[0009] Step 3: Evenly mix 20-40 parts by weight of silica sol, 100-300 parts by weight of modified filler, 12-18 parts by weight of coupling agent and 0.03-0.1 parts by weight of catalyst, pour into a mold, smooth the surface, and let it stand for 10-15 hours to obtain a silicone gel pad;

[0010] Step 4: Sew a Velcro hook surface on the periphery of the polyester-cotton cloth to obtain a skin-friendly layer, adhere the Velcro fleece surface on the periphery of the silicone gel pad to obtain a pressure-resistant layer, and stick the skin-friendly layer on top of the pressure-resistant layer through the Velcro hook surface and the Velcro fleece surface to obtain a medical midriff.

[0011] During the pretreatment of polyester-cotton cloth, sodium percarbonate can oxidize the hydroxyl groups on the cotton fibers into carboxyl groups, thereby improving the liquid absorption performance of the polyester-cotton cloth. At the same time, the capillary fibers on the polyester-cotton cloth are reduced, and the gaps become larger, which is conducive to the attachment of the absorbent; the polyester-cotton cloth impregnated with the absorbent is attached with a super absorbent resin, so that some of the gaps on the polyester-cotton cloth are filled with the super absorbent resin, the gaps become smaller, the capillary absorption effect is enhanced, and the network structure of the super absorbent resin can better lock water molecules. Among them, polyvinyl alcohol plays the role of bonding the super absorbent resin. At the same time, it has good water solubility, making the absorbent system more stable, ensuring the polyester The impregnation effect of cotton cloth; the silicone gel pad made by chemical cross-linking reaction is elastic, shows excellent pressure resistance and shock absorption effect, is beneficial to disperse the pressure on tissue skin, and relieves the discomfort caused by long-term bed rest to patients, and the silicone gel material has excellent permeability to gases such as oxygen and carbon dioxide, and does not absorb water, and has a good anti-seepage effect. The modified filler added not only optimizes the mechanical properties of the silicone gel pad, but also further improves its pressure resistance while enhancing the antibacterial activity of the silicone gel pad; the medical singlet can also be reused, which is environmentally friendly and helps to reduce the economic burden on patients.

[0012] Optionally, the thickness ratio of the polyester-cotton cloth to the silicone gel pad is 1:(2-3).

[0013] Optionally, the super absorbent resin is prepared by the following method:

[0014] Cellulose is dissolved in a mixed solution of tetrabutylammonium fluoride and dimethyl sulfoxide, 4-dimethylaminopyridine is added and stirred evenly, and then an excess of succinic anhydride is added and stirred at room temperature for 20-30 hours. The resulting mixture is poured into methanol and neutralized with 8-15wt% NaOH solution while stirring. The precipitate is filtered and dried to obtain a super absorbent resin.

[0015] During the entire reaction process, the anhydride on succinic anhydride first undergoes an esterification reaction with the hydroxyl group on cellulose to form an ester group and a carboxylate group. The carboxylate group interacts with 4-dimethylaminopyridine through Coulomb force, forming a physical cross-linked structure between the two. Subsequently, through neutralization with NaOH, this physical cross-linked structure disappears, and a carboxylate is formed, thereby obtaining a linear polymer. The unneutralized succinic anhydride acts as both a reactant and a dehydrating agent. After the anhydride on succinic anhydride undergoes an esterification reaction with the hydroxyl group on cellulose to form an ester group and a carboxyl group, the carboxyl group continues to undergo an esterification reaction with the hydroxyl group on cellulose to form a linear polymer containing a diester. Since the ester group is more easily hydrolyzed, the obtained superabsorbent resin can not only exert the high water absorbency of cellulose, but also has excellent biodegradability.

[0016] Optionally, the mass ratio of the cellulose to the succinic anhydride is 1:(35-40);

[0017] The mass ratio of tetrabutylammonium fluoride to dimethyl sulfoxide is 1:(5-6).

[0018] Optionally, the added amount of 4-dimethylaminopyridine is 5-8 wt % of the total mass of cellulose and succinic anhydride.

[0019] Optionally, the cellulose is at least one of wood cellulose, bamboo cellulose and cotton cellulose.

[0020] Optionally, the preparation method of the silica sol comprises the following steps:

[0021] Add oxalic acid to a mixed solution of methyltrimethoxysilane and anhydrous methanol, adjust the pH to 2-4, stir for 20-40 minutes and let stand overnight, then add ammonia water and adjust the pH to 7-9, continue stirring for 20-40 minutes to obtain silica sol.

[0022] Methyltrimethoxysilane first undergoes a hydrolysis reaction under acidic conditions to obtain methyltrihydroxysilane, and then, under the action of ammonia water as a catalyst, dealcohol condensation between methoxy groups and hydroxyl groups, dehydration condensation between hydroxyl groups, and dehydration connection condensation between small silica colloidal particles are carried out. The preparation process is simple and convenient, and the formed silica sol has a stable three-dimensional nano-network structure.

[0023] Optionally, the preparation method of the modified filler comprises the following steps:

[0024] Zinc oxide and lignin in a mass ratio of 1: (0.5-3) are placed in a ball mill and mixed evenly, then 3-5wt% of an organosilicon compound is added and ball milling is continued for 6-12 hours. The ball-to-material ratio is (5-10): 1, the rotation speed is 180-200r / min, and the modified filler is sieved to obtain a particle size of less than 40μm.

[0025] The addition of double fillers enables the silicone gel material to exhibit good antibacterial activity and compressive resistance, and optimizes its tensile strength and elongation at break. The added modifier silicone compound can reduce the surface tension of zinc oxide and lignin, making them evenly dispersed in the silicone gel material and preventing agglomeration.

[0026] Optionally, the organosilicon compound is polydimethylsiloxane or hexamethyldisilazane.

[0027] Optionally, the coupling agent is at least one of coupling agent KH550, coupling agent KH560 and coupling agent KH590;

[0028] The catalyst is isopropyl titanate or tetrabutyl titanate.

[0029] When the coupling agent is added, a large number of alkoxy groups are introduced, which can undergo a series of cross-linking reactions with the silanol groups in the silica sol, making the cross-linking network of the silicone gel pad dense and increasing the constraints on the molecular chains between the cross-linking points, thereby improving its tensile strength and elongation at break.

[0030] According to another aspect of the present application, a medical midline single is provided, which is prepared by any of the above-mentioned preparation methods. The medical midline single includes a pressure-resistant layer and a skin-friendly layer detachably connected to one side of the pressure-resistant layer, the pressure-resistant layer is provided with anti-slip grooves on the side away from the skin-friendly layer, the outer periphery of the skin-friendly layer is provided with a Velcro hook surface, and the outer periphery of the pressure-resistant layer is provided with a Velcro fur surface adapted to the Velcro hook surface.

[0031] In this application, "room temperature" refers to 20-30°C.

[0032] The beneficial effects of this application include but are not limited to:

[0033] 1. The medical midriff of the present application has a skin-softening layer with a base material of polyester-cotton cloth, which is soft and resistant to pulling, thus avoiding damage during use. The water absorbent attached to the polyester-cotton cloth gives the skin-softening layer good water absorption performance, giving patients a dry and comfortable use experience; the silicone gel pad in the pressure-resistant layer is breathable, waterproof and pressure-resistant, and can provide comfort while exerting a pressure-reducing effect. It also has good antibacterial activity and mechanical properties, and can be reused after disinfection, which is environmentally friendly and reduces the economic burden on patients. The anti-slip pattern on the silicone gel pad can prevent it from moving at will during use, so that the injured area is effectively protected; the skin-friendly layer and the pressure-resistant layer are attached together by Velcro, which is easy to use and convenient to replace at any time, and has great application value.

[0034] 2. The preparation method of the medical single in the present application, in the process of preparing the super absorbent resin, by dissolving cellulose in a non-aqueous solvent, the hydrolysis of succinic anhydride during the reaction can be avoided, which is beneficial to improving the reaction selectivity and yield, and the entire reaction is carried out under mild conditions, which helps to inhibit the degradation of high molecular weight polymers during the preparation process; in addition, the reaction process does not involve a cross-linking agent, ensuring the safety of the product; the silicone gel material in the pressure-resistant layer itself is not easy to breed bacteria. By adding modified zinc oxide and lignin to the silicone gel pad, not only the antibacterial activity is further improved, but also the mechanical properties and compressive properties are balanced. While being durable, it is also of great help in reducing local skin friction, reducing pressure injuries and improving body comfort. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] The drawings described herein are used to provide a further understanding of the present application and constitute a part of the present application. The illustrative embodiments of the present application and their descriptions are used to explain the present application and do not constitute an improper limitation on the present application. In the drawings:

[0036] Figure 1 This is a side sectional view of the medical drape involved in an embodiment of the present application.

[0037] Figure 2 This is a top view of the medical midriff involved in an embodiment of the present application.

[0038] Figure 3 This is a bottom view of the medical midriff involved in an embodiment of the present application.

[0039] List of parts and reference numerals:

[0040] 1. Polyester-cotton cloth, 2. Silicone gel pad, 3. Anti-slip pattern, 4. Velcro hook surface, 5. Velcro fleece surface. DETAILED DESCRIPTION

[0041] The endpoints of the ranges and any values ​​disclosed herein are not limited to the precise ranges or values, and these ranges or values ​​should be understood to include values ​​close to these ranges or values. For numerical ranges, the endpoints of each range, the endpoints of each range and individual point values, and the individual point values ​​can be combined with each other to obtain one or more new numerical ranges, which should be considered to be specifically disclosed herein.

[0042] If the specific conditions are not specified in the examples, the experiments were carried out under conventional conditions or those recommended by the manufacturer. The raw materials or instruments used, if the manufacturers are not specified, are all conventional products that can be purchased commercially.

[0043] like Figure 1-3As shown, the present invention provides a medical midline sheet, comprising a pressure-resistant layer and a skin-friendly layer detachably connected to one side of the pressure-resistant layer, so that the skin-friendly layer is conveniently replaced to achieve the reuse of the pressure-resistant layer; the pressure-resistant layer is provided with anti-slip grooves 3 on the side away from the skin-friendly layer to prevent it from moving at will during use, so that the patient's injured position is effectively protected; the skin-friendly layer comprises a polyester-cotton cloth 1 and a Velcro hook surface 4, and the Velcro hook surface 4 is arranged on the periphery of the polyester-cotton cloth 1; the pressure-resistant layer comprises a silicone gel pad 2 and a Velcro fleece surface 5, and the Velcro fleece surface 5 is arranged on the periphery of the silicone gel pad 2; the polyester-cotton cloth 1 and the silicone gel pad 2 are connected to the Velcro fleece surface 5 through the Velcro hook surface 4, which is easy to use and can be recycled after disinfection, which is environmentally friendly and reduces the economic burden on patients.

[0044] Specifically, the thickness ratio of the polyester-cotton cloth 1 to the silicone gel pad 2 is 1:(2-3); preferably 1:2.5, which can achieve the protection purpose and ensure the comfort of the patient.

[0045] Example 1

[0046] A method for preparing a medical single, comprising the following steps:

[0047] Step 1: Take a sodium percarbonate solution with a concentration of 0.05 g / L, adjust the pH to 8, heat it in a water bath to 30° C., put it into the cut degreased polyester-cotton cloth and treat it for 2 hours, take it out and wash it to neutrality, and dry it to obtain the pretreated polyester-cotton cloth;

[0048] Step 2: Dissolve polyvinyl alcohol in water, add super absorbent resin and stir evenly to obtain a water absorbent with a concentration of 0.05 g / L; heat the water absorbent to 40° C., put it into the pretreated polyester-cotton cloth and soak it for 5 minutes, take it out and remove the excess water absorbent, and dry it to obtain the polyester-cotton cloth;

[0049] Step 3: Evenly mix 20 parts by weight of silica sol, 100 parts by weight of modified filler, 12 parts by weight of coupling agent KH550, and 0.03 parts by weight of isopropyl titanate, pour the mixture into a mold, smooth the surface, and let it stand for 10 hours to obtain a silicone gel pad;

[0050] Step 4: Sew a hook surface of Velcro on the periphery of the polyester-cotton cloth to obtain a skin-friendly layer, adhere a fleece surface of Velcro on the periphery of the silicone gel pad to obtain a pressure-resistant layer, and adhere the skin-friendly layer to the top of the pressure-resistant layer through the hook surface of Velcro and the fleece surface of Velcro to obtain a medical midriff;

[0051] Wherein, the super absorbent resin is prepared by the following method:

[0052] Cotton cellulose is dissolved in a mixed solution of tetrabutylammonium fluoride and dimethyl sulfoxide in a mass ratio of 1:5, and then 4-dimethylaminopyridine (5 wt% of the total mass of cotton cellulose and succinic anhydride) is added and stirred evenly. Succinic anhydride is then added and stirred at room temperature for 20 hours. The mass ratio of cotton cellulose to succinic anhydride is 1:35. The resulting mixture is poured into methanol and neutralized with an 8 wt% NaOH solution while stirring. The precipitate is filtered and dried to obtain a super absorbent resin.

[0053] The preparation method of silica sol comprises the following steps:

[0054] Add oxalic acid to a mixed solution of methyltrimethoxysilane and anhydrous methanol, adjust the pH to 2, stir for 40 minutes, and then let it stand overnight. Then add ammonia water and adjust the pH to 7. Continue stirring for 20 minutes to obtain silica sol.

[0055] The preparation method of the modified filler comprises the following steps:

[0056] Zinc oxide and lignin with a mass ratio of 1:0.5 were placed in a ball mill and mixed evenly, and then 3wt% polydimethylsiloxane was added and ball milling was continued for 6h. The ball-to-material ratio was 10:1, the rotation speed was 180r / min, and the modified filler with a particle size of 20μm was obtained after sieving.

[0057] Example 2

[0058] A method for preparing a medical single, comprising the following steps:

[0059] Step 1: Take a sodium percarbonate solution with a concentration of 0.2 g / L, adjust the pH to 10, heat it in a water bath to 50° C., put it into the cut degreased polyester-cotton cloth and treat it for 1 hour, take it out and wash it to neutrality, and dry it to obtain the pretreated polyester-cotton cloth;

[0060] Step 2: Dissolve polyvinyl alcohol in water, add super absorbent resin and stir evenly to obtain a water absorbent with a concentration of 0.1 g / L; heat the water absorbent to 60° C., put it into the pretreated polyester-cotton cloth and soak it for 3 minutes, take it out and remove the excess water absorbent, and dry it to obtain the polyester-cotton cloth;

[0061] Step 3: Evenly mix 40 parts by weight of silica sol, 300 parts by weight of modified filler, 18 parts by weight of coupling agent KH560, and 0.1 parts by weight of tetrabutyl titanate, pour the mixture into a mold, smooth the surface, and let it stand for 15 hours to obtain a silicone gel pad;

[0062] Step 4: Sew a hook surface of Velcro on the periphery of the polyester-cotton cloth to obtain a skin-friendly layer, adhere a fleece surface of Velcro on the periphery of the silicone gel pad to obtain a pressure-resistant layer, and adhere the skin-friendly layer to the top of the pressure-resistant layer through the hook surface of Velcro and the fleece surface of Velcro to obtain a medical midriff;

[0063] Wherein, the super absorbent resin is prepared by the following method:

[0064] The lignocellulose is dissolved in a mixed solution of tetrabutylammonium fluoride and dimethyl sulfoxide in a mass ratio of 1:6, and then 4-dimethylaminopyridine at 8 wt% of the total mass of the lignocellulose and succinic anhydride is added and stirred evenly. Then, succinic anhydride is added and stirred at room temperature for 30 hours. The mass ratio of lignocellulose to succinic anhydride is 1:40. The resulting mixture is poured into methanol and neutralized with a 15 wt% NaOH solution while stirring. The precipitate is filtered and dried to obtain a super absorbent resin.

[0065] The preparation method of silica sol comprises the following steps:

[0066] Add oxalic acid to a mixed solution of methyltrimethoxysilane and anhydrous methanol, adjust the pH to 4, stir for 20 minutes, and then let it stand overnight. Then add ammonia water and adjust the pH to 9. Continue stirring for 40 minutes to obtain a silica sol.

[0067] The preparation method of the modified filler comprises the following steps:

[0068] Zinc oxide and lignin with a mass ratio of 1:3 were placed in a ball mill and mixed evenly, and then 5wt% hexamethyldisilazane was added and ball milling was continued for 12 hours. The ball-to-material ratio was 5:1, the rotation speed was 200r / min, and the modified filler with a particle size of 40μm was obtained after sieving.

[0069] Example 3

[0070] A method for preparing a medical single, comprising the following steps:

[0071] Step 1: Take a sodium percarbonate solution with a concentration of 0.12 g / L, adjust the pH to 9, heat it in a water bath to 40° C., put it into the cut degreased polyester-cotton cloth and treat it for 1.5 hours, take it out and wash it to neutrality, and dry it to obtain the pretreated polyester-cotton cloth;

[0072] Step 2: Dissolve polyvinyl alcohol in water, add super absorbent resin and stir evenly to obtain a water absorbent with a concentration of 0.08 g / L; heat the water absorbent to 50° C., put it into the pretreated polyester-cotton cloth and soak it for 4 minutes, take it out and remove the excess water absorbent, and dry it to obtain the polyester-cotton cloth;

[0073] Step 3: Evenly mix 30 parts by weight of silica sol, 200 parts by weight of modified filler, 15 parts by weight of coupling agent KH590, and 0.07 parts by weight of isopropyl titanate, pour the mixture into a mold, smooth the surface, and let it stand for 12 hours to obtain a silicone gel pad;

[0074] Step 4: Sew a hook surface of Velcro on the periphery of the polyester-cotton cloth to obtain a skin-friendly layer, adhere a fleece surface of Velcro on the periphery of the silicone gel pad to obtain a pressure-resistant layer, and adhere the skin-friendly layer to the top of the pressure-resistant layer through the hook surface of Velcro and the fleece surface of Velcro to obtain a medical midriff;

[0075] Wherein, the super absorbent resin is prepared by the following method:

[0076] The bamboo cellulose was dissolved in a mixed solution of tetrabutylammonium fluoride and dimethyl sulfoxide in a mass ratio of 1:5.5, and then 4-dimethylaminopyridine (7 wt% of the total mass of the bamboo cellulose and succinic anhydride) was added and stirred evenly. Then, succinic anhydride was added and stirred at room temperature for 24 hours. The mass ratio of bamboo cellulose to succinic anhydride was 1:38. The obtained mixture was poured into methanol and neutralized with a 12 wt% NaOH solution while stirring. The precipitate was filtered and dried to obtain a super absorbent resin.

[0077] The preparation method of silica sol comprises the following steps:

[0078] Add oxalic acid to a mixed solution of methyltrimethoxysilane and anhydrous methanol, adjust the pH to 3, stir for 30 minutes, and then let it stand overnight. Then add ammonia water and adjust the pH to 8. Continue stirring for 30 minutes to obtain a silica sol.

[0079] The preparation method of the modified filler comprises the following steps:

[0080] Zinc oxide and lignin with a mass ratio of 1:1.5 were placed in a ball mill and mixed evenly, and then 4wt% polydimethylsiloxane was added and ball milling was continued for 10 hours. The ball-to-material ratio was 8:1, the rotation speed was 190r / min, and the modified filler with a particle size of 30μm was obtained after sieving.

[0081] Example 4

[0082] The difference from Example 3 is that the preparation method of the super absorbent resin is not included, and the super absorbent resin is sodium polyacrylate.

[0083] Comparative Example 1

[0084] The difference from Example 3 is that:

[0085] Excluding step 3, the preparation method of silica sol and the preparation method of modified filler, step 4 is:

[0086] A skin-friendly layer is obtained by sewing a Velcro hook surface on the outer periphery of the polyester-cotton fabric, and a Velcro fleece surface is adhered to the outer periphery of the waterproof layer. The skin-friendly layer is adhered to the upper portion of the waterproof layer through the Velcro hook surface and the Velcro fleece surface, thereby obtaining a medical midriff.

[0087] Among them, the waterproof layer is the waterproof layer in Chinese invention patent CN114344017A.

[0088] Comparative Example 2

[0089] The difference from Example 3 is that step 1 is not included, and step 2 is:

[0090] Dissolve polyvinyl alcohol in water, add super absorbent resin and stir evenly to obtain a water absorbent with a concentration of 0.08 g / L; heat the water absorbent to 50° C., put it into degreased polyester-cotton cloth and soak it for 4 minutes, take it out and remove excess water absorbent, and dry it to obtain polyester-cotton cloth.

[0091] Comparative Example 3

[0092] The difference from Example 3 is that in the preparation method of the super absorbent resin, bamboo cellulose is replaced by hydroxymethyl cellulose.

[0093] Comparative Example 4

[0094] The difference from Example 3 is that in the preparation method of the super absorbent resin, the mass ratio of bamboo cellulose to succinic anhydride is 1:10.

[0095] Comparative Example 5

[0096] The difference from Example 3 is that in the preparation method of the silica sol, the pH of the solution is 5 after adding oxalic acid, and the pH of the solution is 6 after adding ammonia water.

[0097] Comparative Example 6

[0098] The difference from Example 3 is that in the preparation method of the modified filler, zinc oxide and lignin are replaced by silver nitrate and silicon dioxide respectively.

[0099] Comparative Example 7

[0100] The difference from Example 3 is that in the preparation method of the modified filler, the mass ratio of zinc oxide to lignin is 1:0.1.

[0101] Test example

[0102] The performance of the softening layers in Examples 1-4 and Comparative Examples 1-7 was tested. The water absorption performance of the polyester-cotton fabric was evaluated by the change in mass before and after water absorption and swelling. The biodegradability of the polyester-cotton fabric was evaluated by the change in mass over time in a phosphate buffer solution. The test results are shown in Table 1.

[0103] Table 1

[0104] Test number Water absorption rate (g / g) Degradation rate (%) Example 1 2247.1 95.8 Example 2 2259.6 95.1 Example 3 2264.5 96.3 Example 4 1857.2 74.5 Comparative Example 1 2264.5 96.3 Comparative Example 2 2105.8 92.4 Comparative Example 3 1963.6 81.9 Comparative Example 4 2425.1 85.6 Comparative Example 5 2264.5 96.3 Comparative Example 6 2264.5 96.3 Comparative Example 7 2264.5 96.3

[0105] The performance of the pressure-resistant layers in Examples 1-4 and Comparative Examples 1-7 was tested, and the antibacterial performance was tested using three bacteria: Staphylococcus aureus, Escherichia coli, and Candida albicans (the testing method of Comparative Example 1 is the same as that of Chinese invention patent CN114344017A). The interface decompression effect was evaluated by the pressure area distribution. The tensile performance of the silicone gel pad was tested on a tensile testing machine. The test results are shown in Table 2.

[0106] Table 2

[0107]

[0108]

[0109] As can be seen from Tables 1 and 2, the medical middle sheet of the present invention has good water absorption performance, biodegradability, antibacterial activity, mechanical properties and decompression effect, is soft in texture, increases the contact area between the injured part of the patient and the medical middle sheet, effectively reduces the interface pressure between the two, prevents poor blood flow in the compressed part, and prevents pressure injuries around the wound, thereby alleviating the discomfort caused to patients by long-term bed rest. At the same time, by replacing the skin-friendly layer, the purpose of reusing the pressure-resistant layer can be achieved, which saves environment and reduces the economic burden on patients, and has broad application prospects.

[0110] The foregoing is merely an embodiment of the present application, and the scope of protection of the present application is not limited by these specific embodiments, but is determined by the claims of the present application. For those skilled in the art, the present application may have various modifications and variations. Any modifications, equivalent substitutions, improvements, etc. made within the technical ideas and principles of the present application should be included in the scope of protection of the present application.

Claims

1. A method for preparing a medical single, characterized in that: The following steps are involved: Step 1: Take a sodium percarbonate solution with a concentration of 0.05-0.2 g / L, adjust the pH to 8-10, heat it in a water bath to 30-50° C., put it into the cut degreased polyester-cotton cloth and treat it for 1-2 hours, take it out and wash it to neutrality, and dry it to obtain the pretreated polyester-cotton cloth; Step 2: Dissolve polyvinyl alcohol in water, add super absorbent resin and stir evenly to obtain a water absorbent with a concentration of 0.05-0.1 g / L; heat the water absorbent to 40-60°C, put it into the pretreated polyester-cotton cloth and soak it for 3-5 minutes, remove and remove excess water absorbent, and dry it to obtain polyester-cotton cloth; Step 3: Evenly mix 20-40 parts by weight of silica sol, 100-300 parts by weight of modified filler, 12-18 parts by weight of coupling agent and 0.03-0.1 parts by weight of catalyst, pour into a mold, smooth the surface, and let it stand for 10-15 hours to obtain a silicone gel pad; Step 4: Sew a hook surface of Velcro on the periphery of the polyester-cotton cloth to obtain a skin-friendly layer, adhere a fleece surface of Velcro on the periphery of the silicone gel pad to obtain a pressure-resistant layer, and adhere the skin-friendly layer to the top of the pressure-resistant layer through the hook surface of Velcro and the fleece surface of Velcro to obtain a medical midriff; Wherein, the super absorbent resin is prepared by the following method: Dissolve cellulose in a mixed solution of tetrabutylammonium fluoride and dimethyl sulfoxide, add 4-dimethylaminopyridine and stir evenly, then add excess succinic anhydride and stir at room temperature for 20-30 hours, pour the resulting mixture into methanol and neutralize it with 8-15wt% NaOH solution while stirring, filter and dry the precipitate to obtain a super absorbent resin; The preparation method of the modified filler comprises the following steps: Zinc oxide and lignin in a mass ratio of 1:(0.5-3) are placed in a ball mill and mixed evenly, and then 3-5wt% of an organosilicon compound is added. The ball milling is continued for 6-12 hours at a ball-to-material ratio of (5-10):1, a rotation speed of 180-200 r / min, and sieved to obtain a modified filler with a particle size of less than 40 μm; The catalyst is isopropyl titanate or tetrabutyl titanate; The preparation method of the silica sol comprises the following steps: Add oxalic acid to a mixed solution of methyltrimethoxysilane and anhydrous methanol, adjust the pH to 2-4, stir for 20-40 minutes, and then let it stand overnight. Then add ammonia water and adjust the pH to 7-9. Continue stirring for 20-40 minutes to obtain a silica sol. The coupling agent is at least one of coupling agent KH550, coupling agent KH560 and coupling agent KH590.

2. The method for preparing the medical singlet according to claim 1, characterized in that: The thickness ratio of the polyester-cotton cloth to the silicone gel pad is 1:(2-3).

3. The method for preparing the medical singlet according to claim 1, characterized in that: The mass ratio of the cellulose to the succinic anhydride is 1:(35-40); The mass ratio of tetrabutylammonium fluoride to dimethyl sulfoxide is 1:(5-6).

4. The method for preparing the medical veneer according to claim 1, wherein: The added amount of 4-dimethylaminopyridine is 5-8 wt % of the total mass of cellulose and succinic anhydride.

5. The method for preparing the medical singlet according to claim 1, characterized in that: The cellulose is at least one of wood cellulose, bamboo cellulose and cotton cellulose.

6. A medical single, characterized in that: The medical midline single is prepared by the preparation method described in any one of claims 1 to 5, and the medical midline single comprises a pressure-resistant layer and a skin-friendly layer detachably connected to one side of the pressure-resistant layer, the pressure-resistant layer is provided with anti-slip grooves on the side away from the skin-friendly layer, the outer periphery of the skin-friendly layer is provided with a Velcro hook surface, and the outer periphery of the pressure-resistant layer is provided with a Velcro fur surface adapted to the Velcro hook surface.

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