A kind of zhennan incense and preparation method thereof

Abstract

The invention discloses a nanmu incense stick and a preparation method thereof, which is made from nanmu charcoal ash powder, benzoin, radix scutellariae, ginseng, polygala, agarwood, dalbergia odorifera, calcined dragon bone, aconite, frankincense, myrrh, borneol, nanmu sticky powder, nanmu bark stock solution, nanmu leaf cell solution and the like as raw materials. The incense stick of the invention can be directly used for fumigation and moxibustion on the affected part, and can quickly moxibustion the lesion site without being used on the skin. At the same time, the diffusion force is strong enough, the effective area is larger, and a very good therapeutic effect is obtained. In addition, after the incense stick is ignited, the volatile oil enters the patient's body through the respiratory system, which can effectively improve the patient's immunity and achieve the effect of no recurrence. It has low requirements for operators and can be widely promoted and used.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine preparations and provides a zhennan incense stick and a preparation method thereof. Background Art

[0002] In the past, products for treating herpes zoster used a combination of Chinese medicine application and medication. Later, it developed into direct moxibustion with medicinal incense making, which required operators to have a licensed physician or pharmacist certificate.

[0003] Although applying Chinese medicine can also treat shingles, generally speaking, the best effect of applying Chinese medicine is achieved only with fresh herbs, which limits its scope of application.

[0004] By using traditional Chinese medicine ingredients to make incense sticks through processing techniques, the seasonality problem of fresh medicinal materials can be solved. When the hollow incense stick is burned, smoke flows back from both ends of the incense stick, which is a bit like backflow incense. This is because the light smoke part will be emitted upward under the action of heat circulation, while the heavy oil and gas part will flow downward, which can achieve the effect of oil smoke separation. There are currently no reports on the use of incense sticks for the treatment of herpes zoster. Summary of the invention

[0005] In view of this, the object of the present invention is to provide a kind of zhennan incense and its preparation method.

[0006] 1. A nanmu incense stick, which is made by mixing the following raw materials in parts by weight: 30 parts of nanmu charcoal ash powder, 10 parts of benzoin, 10 parts of Radix Angelicae Pubescentis, 8 parts of ginseng, 8 parts of Polygala tenuifolia, 10 parts of agarwood, 2 parts of dalbergia odorifera, 5 parts of calcined dragon bone, 2 parts of aconite, 5 parts of frankincense, 5 parts of myrrh, 5 parts of borneol, 25 parts of nanmu sticky powder, 5 parts of nanmu bark stock solution, and 70 parts of nanmu leaf cell solution;

[0007] Among them, the zhennan charcoal ash powder is obtained by taking the roots and branches of zhennan and making charcoal from ash; the zhennan sticky powder is obtained by taking the bark of zhennan as raw material, boiling in water, taking precipitation, drying, grinding and sieving; the zhennan bark stock solution is obtained by taking the bark of zhennan as raw material, breaking the wall and extracting with alcohol; the zhennan leaf cell fluid is obtained by taking the leaves of zhennan as raw material, breaking the wall and freeze-drying.

[0008] As one of the preferred technical solutions, the Phoebe zhennan is a Yongchuan Phoebe zhennan that is more than 10 years old.

[0009] As one of the preferred technical solutions, the camphor charcoal ash powder is prepared by the following method: take the root branches of camphor nanmu, cut them into small pieces of 1cm×1cm, place the small pieces in a pot, spread them flat, cover them with a lid, sprinkle rice around the lid, turn on high heat, and cook until the rice turns yellow and burnt, turn off the heat, take them out, break the wall with a powder grinder, and pass them through a 100-mesh sieve to obtain the camphor charcoal ash powder.

[0010] As one of the preferred technical solutions, the zhennan sticky powder is prepared by the following method: take the bark of zhennan and cut it into small pieces of 1cm×1cm, put it into a pot, add water to cover the small pieces, boil it, sieve out the precipitated coarse wood powder, dry it at 140℃ for 30 minutes, and then dry it at 28℃ for 2 hours, control it to be below 35℃, grind it, and sieve it to 200 mesh to obtain the zhennan sticky powder.

[0011] As one of the preferred technical solutions, the zhennan bark stock solution is prepared by the following method: taking the zhennan bark, breaking the wall, soaking it in 95° double dealdehyde alcohol with 3 times its mass for 3 months, filtering to obtain the soaking liquid, heating it to boiling to make the alcohol completely volatilize, and the remaining thick liquid is the zhennan bark stock solution.

[0012] As one of the preferred technical solutions, the zhennan tree leaf cell fluid is prepared by the following method: taking zhennan tree leaves, breaking the wall, putting them into a freeze dryer for vacuum freeze drying, and obtaining the zhennan tree leaf cell fluid.

[0013] 2. The preparation method of the aforementioned Phoebe nanmu incense stick comprises the following specific steps:

[0014] (1) First, mix the formulated amounts of benzoin, Radix Angelicae Pubescentis, ginseng, tenuifolia, agarwood, dalbergia odorifera, calcined dracaena, aconite root, frankincense, myrrh, and borneol, grind into powder, sieve, then add the formulated amounts of pyracantha charcoal ash powder and pyracantha sticky powder, stir and mix to obtain a premixed powder;

[0015] (2) then adding the formulated amount of the Phoebe zhennan bark stock solution to the Phoebe zhennan leaf cell solution, stirring and mixing to obtain a premixed solution;

[0016] (3) Finally, add the premixed powder into the premixed liquid, stir for 1 hour, and then put it into a machine to make incense sticks.

[0017] As one of the preferred technical solutions, in step (3), the incense sticks are naturally dried in the shade at a temperature below 28°C.

[0018] As one of the preferred technical solutions, in step (3), the diameter of the incense stick is 6.0 mm. The applicant screened the diameters of the incense sticks, including: 1.5 mm, 3.0 mm and 6.0 mm; after the incense sticks were dried, they were tried on the skin for skin feel testing, and the results showed that: the incense sticks with a diameter of 1.5 mm had too low heat generation, too small effective area, and weak penetration; the incense sticks with a diameter of 3.0 mm had faster heat generation, a larger effective area, and stronger penetration; the incense sticks with a diameter of 6.0 mm had faster heat generation, a large effective area, and strong penetration, and the heat diffusion was fast, which could quickly penetrate the lesion site, and at the same time, the diffusion force was strong enough, and the effective area was larger, which could greatly improve the efficacy of daily smelling incense to improve immunity.

[0019] As one of the further preferred technical solutions, the incense stick is a hollow incense stick.

[0020] The beneficial effects of the present invention are:

[0021] The present invention uses zhennan, benzoin, tangerine peel, ginseng, polygala, agarwood, dalbergia, calcined dragon bone, aconite, frankincense, myrrh, borneol and the like as raw materials to make incense sticks. The incense sticks can be directly used for moxibustion on the affected part, and can quickly moxibustion the lesion site without being used on the skin. At the same time, the diffusion force is strong enough, the effective area is larger, and a very good therapeutic effect is obtained. In addition, after the incense sticks are ignited, the volatile oil enters the patient's body through the respiratory system, which can effectively improve the patient's immunity and achieve the effect of no recurrence. It has low requirements on operators and can be widely promoted and used.

[0022] The present invention is further made into a hollow incense stick, the burning part is used for smelling the fragrance to improve immunity, and the cigarette part is used for directly fumigating the lesion site.

[0023] The nanmu tree of the present invention is selected from Yongchuan nanmu tree that is more than 10 years old, which is a Sichuan medicine authentic medicinal material with better medicinal effect, but is not easy to store. The present invention adopts fresh-keeping to extract aromatic Chinese medicine components, and highly retains its medicinal durability.

[0024] The zhennan incense of the present invention can be used for the treatment of herpes zoster, and at the same time, it is also beneficial to improve the patient's sleep quality, has a good yang-boosting effect, improves immunity, and achieves a fundamental effect. In short, the zhennan incense of the present invention can be used for the treatment of herpes zoster, eczema, abscesses, yang deficiency, etc., improves human immunity, and can be used in hospitals, clinics, rehabilitation health care and physiotherapy shops, and homes.

[0025] Through relevant experimental studies, it was found that compared with ordinary nanmu, the incense sticks made of nanmu used in the present invention are significantly effective in improving the pain level of herpes, sleep quality and quality of life of patients with skin diseases. After the patients inhale the aromatic smell, their anxious emotions can be quickly calmed down, and they can feel happy, effectively improving depression.

[0026] In addition to Phoebe nanmu, ginseng is also an important key raw material of the incense stick of the present invention. Herpes is caused by infection with herpes virus, and ginseng has the effects of replenishing qi and blood, strengthening the spleen and lungs, promoting body fluid and quenching thirst, calming the nerves and increasing intelligence. Since ginseng is a tonic, if herpes patients eat too much ginseng, it may cause internal heat, thereby aggravating the condition. Therefore, it is usually recommended that herpes patients eat less or no ginseng. However, when the incense stick of the present invention is used, the pharmacological effect of the volatile oil of the medicinal material on the human body is achieved, and the volatile oil of ginseng can play an anti-inflammatory and analgesic role, and the smell of ginseng will not cause the patient to get angry. DETAILED DESCRIPTION

[0027] The present invention will be further described below in conjunction with specific implementation modes.

[0028] Embodiment 1:

[0029] A nanmu incense stick is prepared by mixing the following raw materials: 30kg nanmu charcoal ash powder, 10kg benzoin, 10kg radix scutellariae, 8kg ginseng, 8kg polygala, 10kg agarwood, 2kg dalbergia odorifera, 5kg calcined dragon bone, 2kg aconite, 5kg frankincense, 5kg myrrh, 5kg borneol, 25kg nanmu sticky powder, 5kg nanmu bark stock solution, and 70kg nanmu leaf cell solution;

[0030] Wherein, the Phoebe nanmu is Yongchuan Phoebe nanmu which is more than 10 years old.

[0031] The zhennan charcoal ash powder is prepared by the following method: taking the root branches of zhennan, cutting them into small pieces of 1cm×1cm, placing the small pieces in a pot, spreading them flat, covering them with a lid, sprinkling rice around the lid, turning on a high fire, and cooking until the rice turns yellow and burns, turning off the fire, taking them out, breaking the wall with a powder grinder, and passing them through a 100-mesh sieve to obtain the zhennan charcoal ash powder.

[0032] The zhennan sticky powder is prepared by the following method: taking the bark of zhennan tree, cutting it into small pieces of 1cm×1cm, putting it into a pot, adding water to cover the small pieces, boiling, sieving out the precipitated coarse wood powder, drying at 140℃ for 30 minutes, and then low-temperature drying at 28℃ for 2 hours, controlling the temperature below 35℃ to grind it, and sieving it to 200 meshes to obtain the zhennan sticky powder.

[0033] The zhennan bark stock solution is prepared by the following method: taking zhennan bark, breaking the bark, soaking it in 95° double dealdehyde alcohol with 3 times its mass for 3 months, filtering to obtain the soaking liquid, heating it to boiling to make the alcohol completely volatilize, and the remaining thick liquid is the zhennan bark stock solution.

[0034] The zhennan tree leaf cell fluid is prepared by the following method: taking zhennan tree leaves, breaking the wall, putting them into a freeze dryer for vacuum freeze drying, and obtaining the zhennan tree leaf cell fluid.

[0035] The above-mentioned method for preparing the nanmu incense stick has the following specific steps:

[0036] (1) First, mix the formulated amounts of benzoin, Radix Angelicae Pubescentis, Radix Ginseng, Radix Polygalae, Aquilaria Sinensis, Dalbergia Odorata, Osmanthus Fructus, Radix Aconiti Lateralis, frankincense, myrrh, and borneol to powder, sieve through 100 mesh, then add the formulated amounts of Rhizoma Cynomorii charcoal ash powder and Rhizoma Cynomorii sticky powder, stir and mix to obtain a premixed powder;

[0037] (2) then adding the formulated amount of the Phoebe zhennan bark stock solution to the Phoebe zhennan leaf cell solution, stirring and mixing to obtain a premixed solution;

[0038] (3) Finally, add the premixed powder into the premixed liquid, stir for 1 hour, and put it into a machine to make incense sticks with a diameter of 6.0 mm, and dry it naturally in the shade below 28°C.

[0039] Comparative Example 1

[0040] Omit the Chinese fern and keep the rest the same as in Example 1 to obtain ordinary incense sticks.

[0041] Comparative Example 2

[0042] Replace the Chinese nanmu in Example 1 with common nanmu, and keep the rest the same as Example 1 to obtain nanmu incense sticks.

[0043] Comparative Example 3

[0044] The invention discloses a nanmu incense stick, which is prepared by mixing the following raw materials: 15kg nanmu charcoal ash powder, 10kg benzoin, 10kg radix scutellariae, 8kg ginseng, 8kg polygala, 10kg agarwood, 2kg dalbergia odorifera, 5kg calcined dragon bone, 2kg aconite, 5kg frankincense, 5kg myrrh, 5kg borneol, 15kg nanmu sticky powder, 5kg nanmu bark stock solution and 80kg nanmu leaf cell solution.

[0045] The rest is the same as in Example 1.

[0046] Comparative Example 4

[0047] The invention discloses a fern incense stick, which is prepared by mixing the following raw materials: 20kg of fern charcoal ash powder, 10kg of benzoin, 10kg of Radix Angelicae Pubescentis, 8kg of ginseng, 8kg of Polygala tenuifolia, 10kg of agarwood, 2kg of dalbergia odorifera, 5kg of calcined dragon bone, 2kg of aconite root, 5kg of frankincense, 5kg of myrrh, 5kg of borneol, 20kg of fern sticky powder, 5kg of fern bark stock solution and 70kg of fern leaf cell solution.

[0048] The rest is the same as in Example 1.

[0049] Test Example 1

[0050] The incense sticks obtained in Example 1, Comparative Example 3 and Comparative Example 4 were respectively burned in a windless environment. The results showed that the incense stick obtained in Comparative Example 3 was easily extinguished during combustion and the hand-pinched incense stick was easily broken during moxibustion; the incense stick obtained in Comparative Example 4 occasionally extinguished during combustion, and the hand-pinched incense stick was relatively easy to break during moxibustion; the incense stick obtained in Example 1 burned fully, was not easy to break during hand-pinched moxibustion, and could be extinguished in one second upon contact with the skin.

[0051] Test Example 2

[0052] Thirty patients with herpes zoster neuralgia who visited the Department of Neurology, the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from August 2023 to April 2024 were selected, including 13 males and 17 females; aged 40 to 75 years, with an average age of (67.2±10.7) years; the course of disease ranged from 3 months to 13 months, with an average course of (5.4±2.6) months.

[0053] Inclusion criteria: ① Meet the Western medicine and traditional Chinese medicine diagnostic criteria for PHN; ② Age 18-75 years old, regardless of gender; ③ Have not received other systemic treatments for PHN within 1 week before enrollment; ④ The pain is located in the chest, flanks, and back; ⑥ The patient has independent cognitive ability and can correctly fill in the relevant scales based on understanding; ⑥ The patient has normal consciousness and thinking, has good self-awareness, and can complete the questionnaire independently; ⑦ The patient voluntarily participates in this study and obtains informed consent.

[0054] Exclusion criteria: ① Patients who do not meet the inclusion criteria; ② Patients with severe cardiovascular and cerebrovascular diseases, abnormal liver and kidney function, or severe mental illness or malignant tumors; ③ Patients with other diseases that cause pain and affect PHN pain assessment; ④ Patients in pregnancy and lactation; ⑤ Patients who are afraid of incense stick moxibustion treatment; ⑥ Patients who are allergic to the incense stick ingredients or drugs (methylcobalamin) required for treatment; ⑦ Patients with severe skin lesions, infections or scars in the treatment area.

[0055] The experimental group was treated with the Phoebe nanmu incense of Example 1;

[0056] The control group was treated with common incense sticks in Comparative Example 1;

[0057] The experimental results are shown in Table 1.

[0058] Table 1

[0059] VAS HAMD PSQI DLQI <![CDATA[Control group (x ˉ ±s)]]> 5.33±1.658 8.33±4.031 19.33±6.000 6.78±3.962 <![CDATA[Experimental group (x ˉ ±s)]]> 0.30±0.675 3.8±3.615 9.00±6.600 1.70±1.703 t-value 8.494 2.585 3.556 3.561 p-value 0 0.019 0.002 0.005

[0060] As shown in Table 1, the pain score, sleep quality and other indicators of the experimental group are significantly better than those of the control group, and the therapeutic effect of the Phoebe nanmu incense in Example 1 is obvious.

[0061] Test Example 3

[0062] The experimental group was treated with the Phoebe nanmu incense of Example 1;

[0063] The control group was treated with Nanmu incense sticks in comparative example 2;

[0064] The experimental results are shown in Table 2.

[0065] Table 2

[0066] VAS HAMD PSQI DLQI <![CDATA[Control group (x ˉ ±s)]]> 6.30±2.058 7.7±4.990 17.00±8.641 10.60±6.703 <![CDATA[Experimental group (x ˉ ±s)]]> 0.30±0.675 3.8±3.615 9.00±6.600 1.70±1.703 t-value 8.762 2.002 2.327 4.069 p-value 0 0.061 0.032 0.002

[0067] As shown in Table 2, the pain score, sleep quality and other indicators of the experimental group are significantly better than those of the control group, and the therapeutic effect of the Phoebe nanmu incense in Example 1 is obvious.

[0068] In Tables 1 and 2 , VAS is the visual analogue scale for pain, HAMD is the 17-item Hamilton Depression Rating Scale, PSQI is the Pittsburgh Sleep Quality Index, and DLQI is the Dermatology Life Quality Index questionnaire.

[0069] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit it. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the purpose and scope of the technical solution, which should be included in the scope of the claims of the present invention.

Claims

1. A zhennan incense stick, characterized in that: The invention is prepared by mixing the following raw materials in parts by weight: 30 parts of pyracantha charcoal ash powder, 10 parts of benzoin, 10 parts of Radix Angelicae Pubescentis, 8 parts of ginseng, 8 parts of Polygala tenuifolia, 10 parts of agarwood, 2 parts of dalbergia odorifera, 5 parts of calcined dragon bone, 2 parts of aconite root, 5 parts of frankincense, 5 parts of myrrh, 5 parts of borneol, 25 parts of pyracantha sticky powder, 5 parts of pyracantha bark stock solution, and 70 parts of pyracantha leaf cell solution; Among them, the zhennan charcoal ash powder is obtained by taking the roots and branches of zhennan and making charcoal from ash; the zhennan sticky powder is obtained by boiling the bark of zhennan, taking the precipitate, drying, grinding and sieving; the zhennan bark stock solution is obtained by breaking the bark of zhennan and extracting with alcohol; the zhennan leaf cell fluid is obtained by breaking the leaves of zhennan and freeze-drying; The Phoebe nanmu mentioned is Yongchuan Phoebe nanmu which is over 10 years old.

2. The incense stick of Phoebe nanmu according to claim 1, characterized in that: The zhennan charcoal ash powder is prepared by the following method: taking the root branches of zhennan, cutting them into small pieces of 1cm×1cm, placing the small pieces in a pot, spreading them flat, covering them with a lid, sprinkling rice around the lid, turning on a high fire, and cooking until the rice turns yellow and burns, turning off the fire, taking them out, breaking the wall with a powder grinder, and passing them through a 100-mesh sieve to obtain the zhennan charcoal ash powder.

3. The incense stick of Phoebe nanmu according to claim 1, characterized in that: The zhennan sticky powder is prepared by the following method: taking the bark of zhennan tree, cutting it into small pieces of 1cm×1cm, putting it into a pot, adding water to cover the small pieces, boiling, sieving out the precipitated coarse wood powder, drying at 140℃ for 30 minutes, and then low-temperature drying at 28℃ for 2 hours, controlling the temperature below 35℃ to grind it, and sieving it to 200 meshes to obtain the zhennan sticky powder.

4. The zhennan incense stick according to claim 1, characterized in that: The zhennan bark stock solution is prepared by the following method: taking zhennan bark, breaking the bark, soaking it in 95° double dealdehyde alcohol with 3 times its mass for 3 months, filtering to obtain the soaking liquid, heating it to boiling to make the alcohol completely volatilize, and the remaining thick liquid is the zhennan bark stock solution.

5. The zhennan incense stick according to claim 1, characterized in that: The zhennan tree leaf cell fluid is prepared by the following method: taking zhennan tree leaves, breaking the wall, putting them into a freeze dryer for vacuum freeze drying, and obtaining the zhennan tree leaf cell fluid.

6. The method for preparing the Phoebe nanmu incense according to any one of claims 1 to 5, characterized in that: The specific steps are as follows: (1) First, mix the formulated amounts of benzoin, Radix Angelicae Pubescentis, ginseng, tenuifolia, agarwood, dalbergia odorifera, calcined dracaena, aconite root, frankincense, myrrh, and borneol, grind into powder, sieve, then add the formulated amounts of pyracantha charcoal ash powder and pyracantha sticky powder, stir and mix to obtain a premixed powder; (2) then adding the formulated amount of the Phoebe zhennan bark stock solution to the Phoebe zhennan leaf cell solution, stirring and mixing to obtain a premixed solution; (3) Finally, add the premixed powder into the premixed liquid, stir for 1 hour, and then put it into a machine to make incense sticks.

7. The preparation method according to claim 6, characterized in that: In step (3), the incense sticks are naturally dried in the shade at a temperature below 28°C.

8. The preparation method according to claim 6, characterized in that: In step (3), the diameter of the incense stick is 6.0 mm.

9. The preparation method according to claim 6, characterized in that: The incense stick is a hollow incense stick.