Endogenous sunscreen composition and preparation method thereof

Abstract

This invention relates to the field of medical, dental, or cosmetic formulations, and particularly to an endogenous sunscreen composition and its preparation method. The composition comprises the following components in parts by weight: 5-15 parts titanium dioxide, 5-15 parts zinc oxide, 1-5 parts troxerutin, 1-5 parts resveratrol, 1-5 parts modified dendrobium polysaccharide, 1-5 parts oyster polypeptide, 2-10 parts moisturizer, 1-8 parts emulsifier, 10-15 parts skin moisturizer, 0.5-2 parts thickener, 0.1-0.5 parts preservative, and 20-60 parts water. The invention also provides its preparation method. Compared with existing technologies, the sunscreen composition prepared by this invention has a more comprehensive photoprotective effect and resists photoaging and photodamage.

Description

Technical Field

[0001] The present invention relates to the technical field of medical, dental or cosmetic preparations, and in particular to an endogenous sunscreen composition and a preparation method thereof. Background Art

[0002] Skin aging is a complex process caused by the superposition of endogenous and exogenous factors, including natural aging and photoaging. Endogenous aging is natural aging, while exogenous aging refers to skin aging caused by light, harmful substances in the environment such as tobacco, haze and ozone, which manifests as rough, thickened, loose and wrinkled skin, local excessive pigmentation or capillary dilation, and even various benign or malignant tumors. 80% of the causes of skin aging come from photoaging, among which ultraviolet rays are the main influencing factor. The symptoms of photoaged skin are mainly caused by repeated exposure to ultraviolet radiation, resulting in biochemical and morphological changes in the body. Chronic ultraviolet radiation can lead to a decrease in the body's ability to resist oxidative stress, the production of interleukins, TNF-α, and different growth factor receptors, the activation of NF-kB and MAPK pathways, and a decrease in TGF. Continuous excessive ultraviolet radiation causes severe and continuous DNA damage, which exceeds the DNA's own repair ability, causing damage such as nucleic acid unwinding, chain breakage, base mutation, base shedding, pyrimidine dimer production, and abnormal nucleic acid protein cross-linking. According to the central dogma, the structural integrity of DNA directly affects the normal synthesis and expression of proteins, thereby affecting the function of cells. Therefore, it is not only necessary to protect against ultraviolet rays to resist photoaging, but also to start from endogenous light damage caused by DNA damage and other damage is also an important aspect of preventing aging.

[0003] CN110840794A belongs to the field of sunscreen technology, and particularly relates to a blue light and infrared resistant sunscreen composition and its application. The invention provides a blue light and infrared resistant sunscreen composition, comprising: buddleja buddleja extract, needle-shaped titanium dioxide and polysilicone-15; the particle size of the needle-shaped titanium dioxide is 1 to 100 μm. In the invention, the sunscreen composition includes Buddleja buddleja extract, needle-shaped titanium dioxide with a particle size of 1 to 100 μm and polysilicone-15. The combination of the three can simultaneously achieve the effects of resisting ultraviolet rays (UV-A: 320 to 420 nm, UV-B: 275 to 320 nm), near infrared (IR-A and IR-B) and blue light. In addition, polysilicone-15 can also form a synergistic effect with the Buddleja buddleja extract and the needle-shaped titanium dioxide with a particle size of 1 to 100 μm, thereby improving the blue light protection effect of the Buddleja buddleja extract and the infrared light protection effect of the needle-shaped titanium dioxide with a particle size of 1 to 100 μm, thereby further improving the light protection effect of the sunscreen composition.

[0004] CN118304222A belongs to the field of cosmetic technology, and discloses a sunscreen composition, a preparation method and an application thereof. The sunscreen composition comprises, by weight: 2 to 5 parts of a physical sunscreen, 1 to 3 parts of a plant sunscreen, 5 to 10 parts of a vegetable oil and 45 to 50 parts of an auxiliary agent, and deionization is added to make up to 100 parts; the physical sunscreen is lipophilic titanium dioxide and lipophilic ultrafine zinc oxide, the plant sunscreen is one or more of troxerutin, glucosylrutin or resveratrol; the vegetable oil is moringa seed oil and / or sand thorn fruit oil. The invention utilizes a compound of a physical sunscreen, a plant sunscreen and a vegetable oil, which has a synergistic effect. Under the condition of reducing the amount of physical sunscreen used, it can not only achieve better sunscreen performance, reduce the mud rubbing feeling, and improve the skin feel when used, but also the plant sunscreen and the vegetable oil are beneficial to the skin, and have broad application prospects in the field of cosmetics.

[0005] Current sunscreen products are mainly divided into chemical sunscreens and physical sunscreens. Physical sunscreens have good safety and stability, but poor dispersibility, and are prone to false whitening when added in large quantities. Although chemical sunscreens do not feel sticky on the skin, they are highly irritating to the skin and can easily cause allergies. In addition, current sunscreen products mainly protect against ultraviolet rays UVA and UVB, but not against blue light and near-infrared light. In addition, they cannot prevent and repair skin damage caused by photoaging and deep damage. Summary of the invention

[0006] In view of the above-mentioned defects in the prior art, the technical problem to be solved by the present invention is to provide an endogenous sunscreen composition and a preparation method thereof.

[0007] Dendrobium polysaccharide is the general term for polysaccharides in dendrobium, and is the main effective ingredient of dendrobium. It is composed of monosaccharides such as D-xylose, L-arabinose, D-mannose and D-glucose, with D-glucose as the main component. Dendrobium polysaccharide has complex and diverse structures, and has biological activities such as hypoglycemic, antioxidant activity, immunomodulatory effect, and anti-tumor activity. In addition, dendrobium polysaccharide can also inhibit skin damage caused by ultraviolet rays, improve cell vitality, and thus promote the repair of skin after light damage. However, dendrobium polysaccharide, as a macromolecular substance with complex structure, has poor dispersibility and poor water solubility. Therefore, the present invention provides a modified dendrobium polysaccharide, which is extracted and purified from dendrobium and then modified with 2-amino-2-chloropropionic acid, and the number of carboxyl groups of dendrobium polysaccharide is increased after the introduction of amino and carboxyl groups, and the uronic acid on the original sugar chain makes the sugar chains repel each other, and the dispersibility is enhanced. The addition of hydrophilic groups such as amino and carboxyl groups also greatly improves its water solubility. Oyster peptides exert their anti-skin photoaging effects through anti-oxidation, anti-inflammation, and protection of skin cells and extracellular matrix.

[0008] The present invention provides effective protection against UVA and UVB through titanium dioxide and zinc oxide. Troxerutin, resveratrol and the like have good ultraviolet absorption capabilities in the ultraviolet band and have certain absorption and protection effects on blue light. Modified dendrobium polysaccharides and oyster polypeptides repair photodamaged skin through endogenous pathways and play an anti-photoaging role. The sunscreen composition simultaneously prevents ultraviolet rays externally and repairs damage internally, so that the sunscreen composition has multiple functions.

[0009] To achieve the above-mentioned object, the present invention provides an endogenous sunscreen composition, comprising the following components in parts by weight: 5-15 parts of titanium dioxide, 5-15 parts of zinc oxide, 1-5 parts of troxerutin, 1-5 parts of resveratrol, 1-5 parts of modified dendrobium polysaccharide, 1-5 parts of oyster polypeptide, 2-10 parts of moisturizer, 1-8 parts of emulsifier, 10-15 parts of emollient, 0.5-2 parts of thickener, 0.1-0.5 parts of preservative and 20-60 parts of water.

[0010] Furthermore, the moisturizing agent is one of glycerol, hexylene glycol or dextran.

[0011] Furthermore, the emulsifier is one of sorbitan olivate, PEG-30 dipolyhydroxystearate, polyglyceryl-2 isostearate, and PEG-9 polydimethylsiloxyethyl polydimethicone.

[0012] Furthermore, the emollient is one or a mixture of cyclopentasiloxane, diethylhexyl carbonate, octyl polymethylsiloxane or trimethylsiloxysilicate.

[0013] Furthermore, the thickener is one or a mixture of disteardimethylammonium hectorite, microcrystalline wax or magnesium aluminum silicate.

[0014] The preparation method of the modified dendrobium polysaccharide comprises the following steps:

[0015] X1. After crushing the dendrobium, add water, heat and extract for 1 to 2 hours, add ethanol for alcohol precipitation, centrifuge and take the precipitate, wash it with ethanol, filter it, and purify it by column chromatography to obtain dendrobium polysaccharide;

[0016] X2. Add Dendrobium polysaccharide to isopropanol, add 20% sodium hydroxide aqueous solution to mix, stir evenly, then add 2-amino-2-chloropropionic acid, heat to 50-60°C and stir for 2-4 hours, cool to room temperature and adjust the pH to neutral, then dialyze the mixture with water for 2-3 days, add 95% ethanol aqueous solution for alcohol precipitation, centrifuge and freeze-dry the obtained precipitate.

[0017] Furthermore, the solid-liquid ratio during the extraction of Dendrobium is 1:20-30 g / mL.

[0018] Furthermore, the temperature range of the heating extraction is 90-100°C.

[0019] Furthermore, the mass ratio of the dendrobium polysaccharide to 2-amino-2-chloropropionic acid is 1:20-30.

[0020] A method for preparing an endogenous sunscreen composition comprises the following steps:

[0021] S1. Mix the emulsifier, emollient and thickener evenly and heat to 70-85°C as phase A;

[0022] S2. Mix the moisturizer, troxerutin, resveratrol and water evenly, heat to 55-70°C, stir evenly to obtain phase B, mix evenly with phase A, cool to 40-50°C, add titanium dioxide, zinc oxide, modified dendrobium polysaccharide, stir evenly, cool to 30-40°C, add oyster polypeptide, mix evenly, emulsify homogenously, add preservatives, stir evenly, and package.

[0023] Beneficial effects of the present invention:

[0024] Compared with the prior art, the present invention provides effective protection against UVA and UVB through titanium dioxide and zinc oxide. Troxerutin, resveratrol and the like have good ultraviolet absorption capabilities in the ultraviolet band and have certain absorption and protection effects on blue light. Modified dendrobium polysaccharides and oyster polypeptides repair photodamaged skin through endogenous pathways and play an anti-photoaging role. The sunscreen composition simultaneously prevents ultraviolet rays externally and repairs damage internally, so that the sunscreen composition has multiple functions. DETAILED DESCRIPTION

[0025] Titanium dioxide, 100~120nm.

[0026] Zinc oxide, 100~150nm.

[0027] 2-amino-2-chloropropanoic acid, CAS: 89167-65-7.

[0028] Oyster polypeptide, 1500Da, Shaanxi Sinuo Biological.

[0029] Example 1

[0030] A method for preparing an endogenous sunscreen composition comprises the following steps, measured in parts by weight:

[0031] S1. Mix 5 parts of sorbitan olivate, 6 parts of cyclopentasiloxane, 4 parts of diethylhexyl carbonate, 3 parts of trimethylsiloxysilicate and 0.7 parts of disteardimethylammonium hectorite, and heat to 80° C. as phase A;

[0032] S2. Evenly mix 5 parts of glycerin, 2 parts of troxerutin, 2 parts of resveratrol and 50 parts of water, heat to 60°C, stir evenly to obtain phase B, mix evenly with phase A, cool to 45°C, add 10 parts of titanium dioxide, 8 parts of zinc oxide, 2 parts of modified dendrobium polysaccharide, stir evenly, cool to 35°C, add 2 parts of oyster polypeptide, mix evenly, homogenize and emulsify, finally add 0.3 parts of phenoxyethanol, stir evenly and package.

[0033] The preparation method of the modified dendrobium polysaccharide comprises the following steps, in parts by weight:

[0034] X1. Grind 100 parts of Dendrobium officinale, add water, and the solid-liquid ratio is 1:25 g / mL. Heat at 100°C for extraction for 2 h, add ethanol for alcohol precipitation, centrifuge and take the precipitate, wash it with ethanol, filter it, and purify it by column chromatography to obtain Dendrobium officinale polysaccharide;

[0035] X2. Add 10 parts of Dendrobium polysaccharide to 600 parts of isopropanol, add 300 parts of 20% (v / v) sodium hydroxide aqueous solution, mix, stir evenly, then add 250 parts of 2-amino-2-chloropropionic acid, heat to 55°C and stir for 3 hours, cool to room temperature and adjust the pH to neutral, then dialyze the mixture with water for 3 days, add 95% (v / v) ethanol aqueous solution for alcohol precipitation, centrifuge and freeze-dry the obtained precipitate.

[0036] Example 2

[0037] Basically the same as Example 1, the only difference is that the weight portion of troxerutin is 1 part.

[0038] Example 3

[0039] The method is basically the same as Example 1, except that the weight portion of resveratrol is 1 part.

[0040] Comparative Example 1

[0041] Basically the same as Example 1, the only difference is that troxerutin is not added.

[0042] Comparative Example 2

[0043] The method is substantially the same as Example 1, except that resveratrol is not added.

[0044] Comparative Example 3

[0045] The method is basically the same as Example 1, except that no oyster polypeptide is added.

[0046] Comparative Example 4

[0047] The method is basically the same as Example 1, except that the modified Dendrobium polysaccharide is not added.

[0048] Comparative Example 5

[0049] A method for preparing an endogenous sunscreen composition comprises the following steps, measured in parts by weight:

[0050] S1. Mix 5 parts of sorbitan olivate, 6 parts of cyclopentasiloxane, 4 parts of diethylhexyl carbonate, 3 parts of trimethylsiloxysilicate and 0.7 parts of disteardimethylammonium hectorite, and heat to 80° C. as phase A;

[0051] S2. Evenly mix 5 parts of glycerin, 2 parts of troxerutin, 2 parts of resveratrol and 50 parts of water, heat to 60°C, stir evenly to obtain phase B, mix evenly with phase A, cool to 45°C, add 10 parts of titanium dioxide, 8 parts of zinc oxide, 2 parts of dendrobium polysaccharide, stir evenly, cool to 35°C, add 2 parts of oyster polypeptide, mix evenly, homogenize and emulsify, finally add 0.3 parts of phenoxyethanol, stir evenly and package.

[0052] The preparation method of the dendrobium polysaccharide comprises the following steps, measured in parts by weight:

[0053] 100 parts of Dendrobium were crushed and water was added to a solid-liquid ratio of 1:25 g / mL. The mixture was heated at 100°C for extraction for 2 h, and ethanol was added for alcohol precipitation. After centrifugal separation, the precipitate was washed with ethanol, filtered, and purified by column chromatography to obtain Dendrobium polysaccharide.

[0054] Comparative Example 6

[0055] A method for preparing an endogenous sunscreen composition comprises the following steps, measured in parts by weight:

[0056] S1. Mix 5 parts of sorbitan olivate, 6 parts of cyclopentasiloxane, 4 parts of diethylhexyl carbonate, 3 parts of trimethylsiloxysilicate and 0.7 parts of disteardimethylammonium hectorite, and heat to 80° C. as phase A;

[0057] S2. Evenly mix 5 parts of glycerin, 2 parts of troxerutin, 2 parts of resveratrol and 50 parts of water, heat to 60°C, stir evenly to obtain phase B, mix evenly with phase A, cool to 45°C, add 10 parts of titanium dioxide, 8 parts of zinc oxide, 2 parts of modified dendrobium polysaccharide, stir evenly, cool to 35°C, add 2 parts of oyster polypeptide, mix evenly, homogenize and emulsify, finally add 0.3 parts of phenoxyethanol, stir evenly and package.

[0058] The preparation method of the modified dendrobium polysaccharide comprises the following steps, in parts by weight:

[0059] X1. Grind 100 parts of Dendrobium officinale, add water, and the solid-liquid ratio is 1:25 g / mL. Heat at 100°C for extraction for 2 h, add ethanol for alcohol precipitation, centrifuge and take the precipitate, wash it with ethanol, filter it, and purify it by column chromatography to obtain Dendrobium officinale polysaccharide;

[0060] X2. Add 10 parts of Dendrobium polysaccharide to 600 parts of isopropanol, add 300 parts of 20% (v / v) sodium hydroxide aqueous solution, mix, stir evenly, then add 250 parts of chloroacetic acid, heat to 55°C and stir for 3 hours, cool to room temperature and adjust the pH to neutral, then dialyze the mixture with water for 3 days, add 95% (v / v) ethanol aqueous solution for alcohol precipitation, centrifuge and freeze-dry the obtained precipitate.

[0061] Test Example 1

[0062] The SPF value of each test sample is tested in accordance with the specific requirements of the "Determination Method for the Long-wave Ultraviolet Protection Index of Sunscreen Cosmetics". The determination method of the long-wave ultraviolet protection index (PFA) of sunscreen cosmetics mainly involves the calculation of the ratio between the MPPD (minimum sustained pigment darkening amount) of the skin protected by sunscreen cosmetics and the MPPD of the skin protected by no sunscreen cosmetics. Specifically, the PFA value is determined by comparing the minimum ultraviolet radiation dose or irradiation time required for the skin to produce slight darkening under ultraviolet radiation after using sunscreen cosmetics and without using sunscreen cosmetics. This method is designed to evaluate the protective effect of sunscreen cosmetics against long-wave ultraviolet rays, that is, the protective effect of UVA. The calculation of the PFA value is based on the ratio of the MPPD after using sunscreen cosmetics to the MPPD when no sunscreen cosmetics are used. This ratio reflects the ability of sunscreen cosmetics to reduce the pigmentation of the skin caused by UVA irradiation.

[0063] Table 1 UV protection performance test results of sunscreen compositions

[0064]

[0065]

[0066] As can be seen from Table 1, the sunscreen composition prepared by the present invention has a good ultraviolet protection effect. This is because the particles of titanium oxide and zinc oxide have a high refractive index and can reflect and scatter ultraviolet rays. These two substances can also absorb ultraviolet rays, especially radiation in the UVA and UVB bands. After absorbing ultraviolet rays, they also convert energy into heat, thereby reducing damage to the skin. Both titanium oxide and zinc oxide can provide broad-spectrum protection against UVA and UVB. Nano-scale titanium dioxide and zinc oxide particles can provide better sunscreen effects because they are more easily evenly distributed on the skin to form a protective barrier. Therefore, the sunscreen compositions of the present invention have a protection value of SPF60 or above.

[0067] Test Example 2

[0068] Reconstructed human skin epidermis (RHE) was irradiated with blue light under different conditions, and the degree of RHE oxidation (characterized by the content of malondialdehyde) was determined. Negative control product (untreated RHE, not exposed to blue light), positive control product (RHE directly exposed to blue light), and test product (RHE was pre-treated with the compositions of the embodiment and control example before exposure to blue light). RHE was produced from donor keratinocytes and cultured for 7 days. At 8 days, the samples of the embodiment and control example were applied to the RHE (2 mg / cm 2 ) and exposed to 40J / cm 2 After exposure to blue light (427 nm) for 24 h, the product residues were removed and the amount of malondialdehyde (MDA-oxidation marker) in REH was measured to obtain the malondialdehyde increase rate.

[0069] Table 2 Anti-blue light test results of sunscreen composition

[0070] Experimental protocol Malondialdehyde increase rate / % Negative control 4.56 Positive Control 90.54 Example 1 48.76 Example 2 55.34 Example 3 53.68 Comparative Example 1 75.65 Comparative Example 2 76.43 Comparative Example 3 49.35 Comparative Example 4 49.08 Comparative Example 5 48.93 Comparative Example 6 49.37

[0071] Malondialdehyde is an oxide produced by blue light irradiation, which can indirectly indicate the degree of skin oxidation. The higher the malondialdehyde content, the higher the degree of skin oxidation and the greater the damage to the skin. From the comparison of the test results in Table 2, Example 1 has the strongest effect of producing malondialdehyde under blue light irradiation. From the comparison with Examples 2 to 3 and Comparative Examples 1 to 2, it can be seen that troxerutin and resveratrol play a crucial role in blue light protection. Whether or not they are added and the amount of addition will affect the blue light protection effect. This is because troxerutin and resveratrol both have a certain absorption of blue light, so they can achieve the effect of blue light resistance. At the same time, the antioxidant properties of the two also have a certain effect on blue light resistance, so the malondialdehyde increase rate of Example 1 is the lowest.

[0072] Test Example 3

[0073] 33 healthy adult female mice of SPF grade were selected, weighing 27±2g. The back of the mice was shaved with a hair clipper, and then depilatory cream was used to remove hair. The depilatory area was about 2×4cm. The mice were randomly divided into a blank group, a model group, and an experimental group. The blank group did not receive any treatment except depilation; the model group did not receive any repair treatment, and the experimental group applied a sunscreen composition of 2mg / cm on the depilatory area. 2 The mice in the model group and the experimental group were irradiated with continuous wavelength UVA (wavelength: 320-440nm) and UVB (280-320nm) ultraviolet lamps. The irradiation dose was quantified using an ultraviolet irradiator. The total irradiation amount of UVA and UVB was 50mJ / cm 2 , observe and record the skin conditions of the mice. The specific results are shown in Table 3.

[0074] Table 3 Sunscreen composition UV damage repair test results

[0075] Experimental protocol Skin conditions Blank control Good condition Model Group Severe skin redness and swelling Example 1 Only slight redness of the skin Example 2 Only slight redness of the skin Example 3 Only slight redness of the skin Comparative Example 1 Only slight redness of the skin Comparative Example 2 Only slight redness of the skin Comparative Example 3 Redness and swelling of the skin Comparative Example 4 Redness and swelling of the skin Comparative Example 5 Slight redness and swelling of the skin Comparative Example 6 Slight redness and swelling of the skin

[0076] From the results in Table 3, it can be seen that the model group suffered from photodamage under ultraviolet irradiation without protection, thus causing redness and swelling of the skin, while the skin conditions of the examples and control examples were less severe than those of the model group due to the application of the sunscreen composition. Compared with the results of Examples 1 to 3 and Control Examples 1 to 2 and Control Examples 3 and 4, it can be proved that oyster polypeptides and modified dendrobium polysaccharides have a certain inhibitory and repairing effect on skin photodamage, because dendrobium polysaccharides can inhibit skin damage caused by ultraviolet rays, improve cell viability, and thus promote skin repair after photodamage, while oyster polypeptides can protect skin cells and extracellular matrix. Compared with control examples 5 and 6, in Example 1, the purified dendrobium polysaccharide was not modified in control example 5, and the purified dendrobium polysaccharide was modified by chloroacetic acid in control example 6. In Example 1, the dendrobium was extracted and purified and then modified by 2-amino-2-chloropropionic acid. The introduction of amino and carboxyl groups increased the number of carboxyl groups in the dendrobium polysaccharide, and the uronic acid on the original sugar chain made the sugar chains repel each other, and the dispersibility was enhanced. The addition of hydrophilic groups such as amino and carboxyl groups also greatly improved its water solubility, so that the modified dendrobium polysaccharide can play a better role in the sunscreen composition.

[0077] The preferred specific embodiments of the present invention are described in detail above. It should be understood that a person skilled in the art can make many modifications and changes based on the concept of the present invention without creative work. Therefore, any technical solution that can be obtained by a person skilled in the art through logical analysis, reasoning or limited experiments based on the concept of the present invention on the basis of the prior art should be within the scope of protection determined by the claims.

Claims

1. An endogenous sunscreen composition, characterized in that: The invention comprises the following components in parts by weight: 5-15 parts of titanium dioxide, 5-15 parts of zinc oxide, 1-5 parts of troxerutin, 1-5 parts of resveratrol, 1-5 parts of modified dendrobium polysaccharide, 1-5 parts of oyster polypeptide, 2-10 parts of moisturizer, 1-8 parts of emulsifier, 10-15 parts of emollient, 0.5-2 parts of thickener, 0.1-0.5 parts of preservative and 20-60 parts of water; The preparation method of the modified dendrobium polysaccharide comprises the following steps: X1. After crushing the dendrobium, add water, heat and extract for 1 to 2 hours, add ethanol for alcohol precipitation, centrifuge and take the precipitate, wash it with ethanol, filter it, and purify it by column chromatography to obtain dendrobium polysaccharide; X2. Add Dendrobium polysaccharide to isopropanol, add 20% sodium hydroxide aqueous solution to mix, stir evenly, then add 2-amino-2-chloropropionic acid, heat to 50-60°C and stir for 2-4 hours, cool to room temperature and adjust the pH to neutral, then dialyze the mixture with water for 2-3 days, add 95% ethanol aqueous solution for alcohol precipitation, centrifuge and freeze-dry the obtained precipitate.

2. The endogenous sunscreen composition according to claim 1, characterized in that The moisturizing agent is one of glycerol, hexylene glycol or dextran.

3. The endogenous sunscreen composition according to claim 1, characterized in that The emulsifier is one of sorbitan olivate, PEG-30 dipolyhydroxystearate, polyglyceryl-2 isostearate, and PEG-9 polydimethylsiloxyethyl polydimethylsiloxane.

4. The endogenous sunscreen composition according to claim 1, characterized in that The emollient is one or a mixture of cyclopentasiloxane, diethylhexyl carbonate, octyl polymethylsiloxane or trimethylsiloxysilicate.

5. The endogenous sunscreen composition according to claim 1, characterized in that The thickener is one of disteardimethylammonium hectorite, microcrystalline wax or magnesium aluminum silicate or a mixture of several of them.

6. The endogenous sunscreen composition according to claim 1, characterized in that The solid-liquid ratio during the dendrobium extraction is 1:20-30 g / mL, and the temperature range of the heating extraction is 90-100° C.

7. The endogenous sunscreen composition according to claim 1, characterized in that The mass ratio of the dendrobium polysaccharide to 2-amino-2-chloropropionic acid is 1:20-30.

8. A method for preparing the endogenous sunscreen composition according to any one of claims 1 to 7, characterized in that: The steps include: S1. Mix the emulsifier, emollient and thickener evenly and heat to 70-85°C as phase A; S2. Mix the moisturizer, troxerutin, resveratrol and water evenly, heat to 55-70°C, stir evenly to obtain phase B, mix evenly with phase A, cool to 40-50°C, add titanium dioxide, zinc oxide, modified dendrobium polysaccharide, stir evenly, cool to 30-40°C, add oyster polypeptide, mix evenly, emulsify homogenously, add preservatives, stir evenly, and package.

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