A tumor sampling device for easily separating tumors

Abstract

The present invention discloses a tumor sampling device that is convenient for separating tumors, and relates to the technical field of tumor sampling equipment, including: a sampling tube, the sampling tube is arranged in a needle tube and can move along the length direction of the needle tube between a first position and a second position, a separation mechanism is embedded in the sampling tube and arranged near the bottom of the sampling tube, the separation mechanism can separate the tumor sample from the tumor, an adsorption sampling mechanism penetrates the needle tube and is connected to the sampling tube, and the adsorption sampling mechanism can suck the tumor sample out of the sampling tube. During the tumor sampling process, the sampling tube is first inserted into the tumor, and then the tumor sample is separated from the tumor by the separation mechanism. Although there is a sequential operation sequence, the needle does not need to be pulled out during the operation, and the position of the sampling tube after being inserted into the tumor does not need to be changed. As a whole, tumor sampling can be achieved in one operation, avoiding tumor debris from falling into non-tumor areas and reducing the risk of tumor metastasis.

Description

Technical Field

[0001] The present invention relates to the technical field of tumor sampling equipment, and in particular to a tumor sampling device which is convenient for separating tumors. Background Art

[0002] Tumors are neoplasms formed by the proliferation of local tissue cells under the action of various tumorigenic factors. Tumors are divided into benign tumors and malignant tumors. Benign tumors grow slowly, usually have capsules, and are clearly separated from surrounding tissues. They generally do not metastasize, are less harmful to the body, and are usually not prone to recurrence after surgical resection. Malignant tumors grow rapidly, can invade surrounding tissues, have no capsules, often metastasize, and are more harmful to the body. After discovering a tumor, doctors need to take samples to test whether the tumor is malignant or benign, so that doctors can treat it symptomatically.

[0003] Tumor sampling is an important means of obtaining tumor tissue samples for pathological diagnosis and analysis. Tumor sampling methods often use syringes to sample tumors, and use the negative pressure generated by the syringe to absorb tumor tissue. However, this sampling method is not easy to succeed in one go, and tumor samples are not easy to cut and separate.

[0004] In order to solve this technical problem, patent CN111887903A discloses a tumor sampling device that is convenient for separating tumors, in which an electric shaft and a cutting knife are arranged at the end of the insertion rod. Under normal circumstances, the electric shaft drives the cutting knife to fit together with the side wall of the insertion rod, and the torsion spring is compressed at this time; when in use, the electric shaft is powered off, and under the action of the torsion spring, the cutting knife moves away from the insertion rod, driving the cutting knife to be inserted into the tumor next to the insertion rod, and then moves upward to separate the sample from the tumor. In this patent, the elastic force of the torsion spring is used as the cutting force of the cutting knife, which itself has extremely poor stability, and the tumor is generally located in the patient's body. The insertion rod with the cutting knife and the electric shaft is basically unable to enter or move out, and is not very practical.

[0005] Patent CN113598841A discloses a tumor sampling device that is convenient for separating tumors. It uses a transverse cutting device and a longitudinal cutting device to achieve tumor sampling and separation. However, when using, the transverse cutting device and the longitudinal cutting device have a sequential use order. The tumor needs to be cut longitudinally to form an incision first, and then the transverse cutting device is inserted into the incision to cut the tumor sample transversely to achieve sampling. This patent cannot complete the tumor sampling operation in one operation. This multiple operation method may cause some tumor debris to fall into the non-tumor area of ​​the patient's body, further increasing the risk of tumor metastasis. In addition, it is also difficult to accurately insert the transverse cutting device into the incision.

[0006] In view of this, how to provide a tumor sampling device that can complete tumor sampling in one operation, facilitate separation of samples from the tumor body, and reduce the risk of tumor metastasis is an urgent problem that technical personnel in this field need to solve. Summary of the invention

[0007] The purpose of the present invention is to provide a tumor sampling device which is convenient for separating tumors, so as to solve the problems existing in the prior art.

[0008] To achieve the above object, the present invention provides the following solution: The present invention provides a tumor sampling device for facilitating separation of tumors, comprising:

[0009] A needle tube, wherein the bottom of the needle tube is connected to a needle;

[0010] a sampling tube, the sampling tube being arranged in the needle tube and being movable between a first position and a second position along the length direction of the needle tube; when the sampling tube is located at the first position, the sampling tube is located in the needle tube; when the sampling tube is located at the second position, the sampling tube extends from the needle head and is inserted into the tumor, and the tumor entering the sampling tube is a tumor sample;

[0011] A separation mechanism, which is embedded in the sampling tube and disposed near the bottom of the sampling tube, and can separate the tumor sample from the tumor;

[0012] The adsorption sampling mechanism runs through the needle tube and is connected with the sampling tube. The adsorption sampling mechanism can absorb the tumor sample from the sampling tube.

[0013] Furthermore, the sampling tube includes an inner tube body and an outer tube body, the outer tube body is sleeved on the outside of the inner tube body, an installation chamber is formed between the outer tube body and the inner tube body, the separation mechanism is arranged in the installation chamber, the inner tube body is provided with an installation hole corresponding to the installation chamber, and the output end of the separation mechanism is arranged corresponding to the installation hole.

[0014] Furthermore, the separation mechanism is a low-temperature refrigeration element, and the connecting wires of the low-temperature refrigeration element pass through the outer tube body and are electrically connected to the low-temperature freezing power supply.

[0015] Furthermore, the separation mechanism is a laser emitter, the laser emitter is connected to a transmission optical fiber, the transmission optical fiber passes through the outer tube body and is connected to a laser generator.

[0016] Furthermore, it also includes:

[0017] A limiting member, the limiting member is fixedly arranged in the needle tube and close to the top of the needle tube, and a limiting hole is formed in the middle of the limiting member through the upper and lower surfaces;

[0018] A connecting rod, the top of the sampling tube is sealed, one end of the connecting rod is fixedly connected to the top of the sampling tube, the other end of the connecting rod passes through the limiting hole and extends outside the needle tube, and the connecting rod is adapted in shape to the limiting hole;

[0019] A pressing plate is fixedly arranged on the other end of the connecting rod.

[0020] Furthermore, the adsorption sampling mechanism comprises:

[0021] A connecting hose, one end of which passes through the needle tube and is connected to the sampling tube;

[0022] A sampling chamber, wherein a sample receiving part is arranged in the sampling chamber, and the other end of the connecting hose extends into the sampling chamber and corresponds to the position of the sample receiving part;

[0023] A negative pressure pump is connected to the sampling chamber through a negative pressure tube.

[0024] Furthermore, the outer tube body extends upward to form an extension portion, one end of the connecting hose passes through the needle tube and the extension portion and is connected to the upper tube opening of the inner tube body, and the top of the extension portion is sealed and fixedly connected to the connecting rod.

[0025] Furthermore, it also includes a universal mechanical arm, the needle tube is fixedly arranged on the universal mechanical arm, and the universal mechanical arm has a locking device. When the locking device is opened, the position of the needle tube is fixed.

[0026] The present invention discloses the following technical effects:

[0027] 1. This application uses a sampling tube combined with a separation mechanism to achieve tumor sampling. The sampling tube is located inside the needle tube and can be extended from the needle. The separation mechanism is embedded in the sampling tube and close to the bottom of the sampling tube, and can enter and exit the patient's body through the needle. During the tumor sampling process, the sampling tube is first inserted into the tumor, and then the tumor sample is separated from the tumor by the separation mechanism. Although there is a sequence of operations, the needle does not need to be pulled out during the operation, and the position of the sampling tube after insertion into the tumor does not need to be changed. As a whole, tumor sampling can be achieved in one operation, which prevents tumor debris from falling into non-tumor areas and reduces the risk of tumor metastasis.

[0028] 2. The tumor sample is separated from the tumor using a cryogenic refrigeration element or a laser emitter. The cryogenic refrigeration element can quickly freeze the separation point between the tumor sample and the tumor. The formation of ice crystals in the cells causes the cells to rupture, thereby separating the tumor from the body. The laser emitter can cut and separate the tumor tissue at the bottom by precisely controlling the energy and focus of the laser. Both methods have the advantages of small structural size and can be installed in small precision instruments. Both methods have excellent tumor sample separation effects. Compared with traditional technologies, the separation of tumor samples from tumors is more thorough. The separated tumor samples are adsorbed and collected by an adsorption sampling mechanism, and the adsorption force requirements of the adsorption sampling mechanism are greatly reduced.

[0029] 3. The needle tube is fixed on the universal robotic arm. When the operator inserts the needle near the tumor in the patient's body, the position of the needle can be locked by the locking device of the robotic arm. At this time, the operator can perform the tumor sample sampling operation, so that one operator can complete the tumor sampling. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0031] Figure 1 It is a schematic diagram of the overall structure of the present invention;

[0032] Figure 2 Schematic diagram of the sampling tube structure;

[0033] Figure 3 This is a schematic diagram of the bottom structure of the sampling tube;

[0034] Figure 4 It is the layout diagram of the separation mechanism;

[0035] Figure 5 It is a schematic diagram of the limiter structure;

[0036] Among them, 1. needle tube; 101. needle; 2. sampling tube; 201. inner tube body; 202. outer tube body; 2021. extension part; 203. installation chamber; 3. connecting wires; 4. low-temperature freezing power supply; 5. limiter; 501. limiter hole; 6. connecting rod; 7. pressure plate; 8. connecting hose; 9. sampling chamber; 10. sample receiving part; 11. negative pressure pump; 12. negative pressure tube; 13. separation mechanism. DETAILED DESCRIPTION

[0037] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0038] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0039] Example 1

[0040] Reference Figure 1-Figure 5The embodiment of the present invention discloses a tumor sampling device that is convenient for separating tumors, including: a needle tube 1, a needle head 101 is connected to the bottom of the needle tube 1; a sampling tube 2, the outer diameter of the sampling tube 2 is slightly smaller than the outer diameter of the needle tube 1, and the specific outer diameter of the needle tube 1 can be adjusted according to the actual tumor sampling requirements. The thicker the needle tube 1 is, the thicker the outer diameter of the sampling tube 2 is, and the larger the sample size after tumor sampling is. The sampling tube 2 is arranged in the needle tube 1 and can move along the length direction of the needle tube 1 between the first position and the second position. The needle head 101 and the sampling tube 2 are generally located on the same axis. When the sampling tube 2 is located at the first position, the sampling tube 2 is located in the needle tube 1 as a whole; when the sampling tube 2 is located at the second position, the bottom of the sampling tube 2 extends from the needle head 101 and can be inserted into the tumor. The tumor entering the sampling tube 2 is a tumor sample. The sampling tube 2 is a hollow cylinder. The tumor sample is a cylindrical sample. The thickness of the sampling tube 2 should be as small as possible to ensure the smoothness of inserting the tumor.

[0041] The separation mechanism 13 is embedded in the sampling tube 2 and arranged near the bottom of the sampling tube 2. The separation mechanism 13 can separate the tumor sample from the tumor; the adsorption sampling mechanism passes through the needle tube 1 and is connected to the sampling tube 2. The adsorption sampling mechanism can suck the tumor sample out of the sampling tube 2.

[0042] like Figure 1-Figure 4 As shown, the sampling tube 2 includes an inner tube body 201 and an outer tube body 202. The outer tube body 202 is sleeved on the outer side of the inner tube body 201. A mounting chamber 203 is formed between the outer tube body 202 and the inner tube body 201. The separation mechanism 13 is arranged in the mounting chamber 203. The inner tube body 201 is provided with a mounting hole corresponding to the mounting chamber 203. The output end of the separation mechanism 13 is arranged corresponding to the mounting hole. Figure 3 and Figure 4 As shown, in order to avoid the sampling tube 2 from affecting the separation mechanism 13 when inserted into the tumor, the separation mechanism 13 is not set at the bottom of the installation chamber 203, but a certain gap is left between the bottom of the installation chamber 203. The bottom of the inner tube body 201 and the bottom of the outer tube body 202 are connected as a whole, as the plug-in end for inserting into the tumor, in order to improve the plug-in effect, the inner tube body 201 and the outer tube body 202 below the separation mechanism 13 can be relatively close to form a tip or a shape close to the tip. Of course, the sampling tube 2 formed by the inner tube body 201 and the outer tube body 202 itself has a very small size and thickness, and can be fully inserted into the tumor, so it can also be set as Figure 3 , Figure 4 Straight line shown.

[0043] like Figure 2-Figure 4 As shown, in this embodiment, the separation mechanism 13 is a low-temperature refrigeration element, and the connecting wire 3 of the low-temperature refrigeration element passes through the outer tube body 202 and is electrically connected to the low-temperature freezing power supply 4.

[0044] like Figure 1As shown, in this embodiment, it also includes: a limit member 5, which is fixedly arranged in the needle tube 1 and close to the top of the needle tube 1, and the middle part of the limit member 5 passes through the upper and lower surfaces to open a limit hole 501; a connecting rod 6, the top of the sampling tube 2 is sealed, one end of the connecting rod 6 is fixedly connected to the top of the sampling tube 2, and the other end of the connecting rod 6 passes through the limit hole 501 and extends outside the needle tube 1, and the connecting rod 6 is adapted in shape to the limit hole 501; a pressing plate 7, which is fixedly arranged at the other end of the connecting rod 6.

[0045] The adsorption sampling mechanism includes: a connecting hose 8, one end of which passes through the needle tube 1 and is connected to the sampling tube 2; a sampling chamber 9, in which a sample receiving part 10 is arranged, and the other end of the connecting hose 8 extends into the sampling chamber 9 and corresponds to the position of the sample receiving part 10; a negative pressure pump 11, which is connected to the sampling chamber 9 through a negative pressure tube 12. The outer tube body 202 extends upward to form an extension part 2021, one end of the connecting hose 8 passes through the needle tube 1 and the extension part 2021 and is connected to the upper tube opening of the inner tube body 201, and the top of the extension part 2021 is sealed and fixedly connected to the connecting rod 6.

[0046] In this embodiment, a universal mechanical arm is also included, and the needle tube 1 is fixedly arranged on the universal mechanical arm. The universal mechanical arm has a locking device. When the locking device is opened, the position of the needle tube 1 is fixed.

[0047] The specific working process is as follows:

[0048] The operator fixes the needle tube 1 to the universal robot arm, determines the insertion angle and insertion position of the needle 101 according to the patient's tumor position, inserts the needle 101 into the patient's body close to the tumor, activates the locking device of the universal robot arm, and fixes the needle tube 1.

[0049] The operator presses the pressing plate 7 to insert the sampling tube 2 into the tumor, and the tumor sample enters the sampling tube 2 .

[0050] The low-temperature freezing power supply 4 is started, and the low-temperature freezing power supply 4 supplies power to the low-temperature refrigeration element, so that the connection between the tumor sample and the tumor is quickly cooled to -40°C, and the tumor sample is separated from the tumor.

[0051] The negative pressure pump 11 is started to exhaust the air in the sampling chamber 9 and the connecting hose 8. Under the influence of negative pressure, the tumor sample separated from the tumor enters the sampling chamber 9 along the inner tube 201 and the connecting hose 8 and falls on the sample receiving part 10, completing the tumor sample collection and taking the needle 101 out of the patient's body.

[0052] The collected tumor samples were observed and found to be completely separated from the tumor, with a basically smooth separation surface formed at the separation site. The tumor samples, tumors, and areas near the tumors were observed and no vascular constriction or nerve damage was found. There was cell damage in a very small area at the tumor separation site, but it did not affect the normal function of the body. The tumor samples can be used by doctors to determine whether the tumor is benign or malignant.

[0053] Example 2

[0054] The difference between this embodiment and embodiment 1 is that the separation mechanism 13 is a laser emitter, which is connected to a transmission optical fiber, which penetrates the outer tube 202 and is connected to a laser generator. The laser generator uses a carbon dioxide laser with a power of 15 watts.

[0055] The collected tumor samples were observed and found to be completely separated from the tumor, with a basically smooth separation surface formed at the separation point. No vascular constriction or nerve damage was found in the tumor samples and the tumor. There was cell damage in a very small range, but it did not affect the normal function of the body. The tumor samples can be used by doctors to determine whether the tumor is benign or malignant.

[0056] It should be noted that, regardless of whether a laser emitter or a low-temperature refrigeration element is used, the sampling tube 2 can separate the tumor sample from the tumor. It is precisely because of the separation of the sampling tube 2 that the tumor sample can be smoothly separated from the tumor without affecting the blood vessels, nerves, and cells in the tumor and the surrounding area.

[0057] In the description of the present invention, it should be understood that the terms "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside" and "outside" etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0058] The embodiments described above are only descriptions of the preferred modes of the present invention, and are not intended to limit the scope of the present invention. Without departing from the design spirit of the present invention, various modifications and improvements made to the technical solutions of the present invention by ordinary technicians in this field should all fall within the protection scope determined by the claims of the present invention.

Claims

1. A tumor sampling device for facilitating separation of tumors, characterized in that: include: A needle tube (1), wherein the bottom of the needle tube (1) is connected to a needle (101); A sampling tube (2), the sampling tube (2) being arranged in the needle tube (1) and being able to move along the length direction of the needle tube (1) between a first position and a second position; when the sampling tube (2) is located in the first position, the sampling tube (2) is located in the needle tube (1); when the sampling tube (2) is located in the second position, the sampling tube (2) extends from the needle head (101) and is able to be inserted into a tumor; the tumor entering the sampling tube (2) is a tumor sample; A separation mechanism (13), wherein the separation mechanism (13) is embedded in the sampling tube (2) and arranged close to the bottom of the sampling tube (2), and the separation mechanism (13) is capable of separating the tumor sample from the tumor; An adsorption sampling mechanism, the adsorption sampling mechanism passes through the needle tube (1) and is connected to the sampling tube (2), and the adsorption sampling mechanism can absorb the tumor sample from the sampling tube (2); The sampling tube (2) comprises an inner tube body (201) and an outer tube body (202); the outer tube body (202) is sleeved on the outer side of the inner tube body (201); an installation chamber (203) is formed between the outer tube body (202) and the inner tube body (201); the separation mechanism (13) is arranged in the installation chamber (203); the inner tube body (201) is provided with an installation hole corresponding to the installation chamber (203); and the output end of the separation mechanism (13) is arranged corresponding to the installation hole; The separation mechanism (13) is a cryogenic refrigeration element or a laser emitter, and the connecting wire (3) of the cryogenic refrigeration element passes through the outer tube body (202) and is electrically connected to the cryogenic freezing power supply (4); the laser emitter is connected to a transmission optical fiber, and the transmission optical fiber passes through the outer tube body (202) and is connected to a laser generator.

2. A tumor sampling device for facilitating separation of tumors according to claim 1, characterized in that: Also includes: A limiting member (5), the limiting member (5) being fixedly arranged in the needle tube (1) and close to the top of the needle tube (1), and a limiting hole (501) is formed in the middle of the limiting member (5) through the upper and lower surfaces; A connecting rod (6), the top of the sampling tube (2) is sealed, one end of the connecting rod (6) is fixedly connected to the top of the sampling tube (2), the other end of the connecting rod (6) passes through the limiting hole (501) and extends outside the needle tube (1), and the connecting rod (6) is adapted in shape to the limiting hole (501); A pressing plate (7), wherein the pressing plate (7) is fixedly arranged on the other end of the connecting rod (6).

3. A tumor sampling device for facilitating separation of tumors according to claim 2, characterized in that: The adsorption sampling mechanism comprises: A connecting hose (8), one end of which passes through the needle tube (1) and is connected to the sampling tube (2); A sampling chamber (9), wherein a sample receiving part (10) is arranged in the sampling chamber (9), and the other end of the connecting hose (8) extends into the sampling chamber (9) and corresponds to the position of the sample receiving part (10); A negative pressure pump (11), wherein the negative pressure pump (11) is connected to the sampling chamber (9) via a negative pressure pipe (12).

4. A tumor sampling device for facilitating separation of tumors according to claim 3, characterized in that: The outer tube body (202) extends upward to form an extension portion (2021); one end of the connecting hose (8) passes through the needle tube (1) and the extension portion (2021) and is connected to the upper tube opening of the inner tube body (201); the top of the extension portion (2021) is sealed and fixedly connected to the connecting rod (6).

5. A tumor sampling device for facilitating separation of tumors according to claim 1, characterized in that: It also comprises a universal mechanical arm, on which the needle tube (1) is fixedly arranged, and the universal mechanical arm has a locking device. When the locking device is opened, the position of the needle tube (1) is fixed.

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