A traditional Chinese medicine composition for weight loss and blood lipid reduction, and a preparation method and use thereof

Abstract

The present application provides a kind of traditional Chinese medicine composition for weight loss, hypolipidemic and its preparation method and use.The traditional Chinese medicine composition is made of the following raw materials by weight parts: Bai Zhi 10-20 parts, Dang Shen 10-20 parts, Tu Fu Ling 15-25 parts, Dan Shen 15-25 parts, Rou Fu Zhi Shu 5-15 parts, Rou Fu Yi Ren 15-25 parts, Chen Pi 10-20 parts, Fa Ban Xia 10-20 parts, Shan Zha 5-15 parts, Huang Lian Pian 15-25 parts, Chao Jue Ming Zi 15-25 parts, Rou Fu Cang Zhu 5-15 parts, Gan Jiang 5-15 parts, Xiao Tong Cao 2-8 parts.The traditional Chinese medicine composition of the present application is based on the theory of TCM syndrome differentiation, and is reasonable in prescription compatibility, with significant effects of weight loss and lipid-lowering.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for weight loss and blood lipid reduction and a preparation method thereof. BACKGROUND

[0002] Obesity is prone to cause hypertension, diabetes, cardiovascular and cerebrovascular diseases, cancer, asthma, sleep disorders, liver dysfunction, renal insufficiency and infertility and other diseases. It is well known that when the energy intake of the body is higher than the energy output, it is the main mechanism of obesity, characterized by excessive accumulation of fat or abnormal accumulation of fat in the body. Obesity and its complications can seriously affect the quality of life of individual patients and also cause serious economic burden to society.

[0003] The etiology of obesity is very complex, and so far its etiology is still not very clear, but it is generally believed that obesity is caused by the combined action of genetic factors and environmental factors. According to the etiology, obesity can be divided into two types, namely simple obesity and secondary obesity, the latter accounting for about 4%, and the inducement is generally endocrine disorder or metabolic dysfunction in the body, which can be treated according to the etiology, but simple obesity is difficult to treat, and most of this group of people are caused by genetic factors, environmental factors, unhealthy diet and bad living habits. So far, there is no specific drug for the treatment of obesity, and the main treatment is a comprehensive treatment plan mainly based on behavior therapy, diet control and reasonable exercise, supplemented by drug and surgical treatment.

[0004] At present, the incidence of simple obesity is increasing year by year, so it is particularly important to explore effective and safe weight loss drugs. Because the treatment of obesity by western medicine is very limited, it is urgent to seek other safer and more effective drugs for the treatment of obesity. Most of the weight loss drugs on the market are strictly prohibited from being widely used in clinical practice because of their many adverse reactions, poor tolerance, and some can cause serious complications, while some advantages of traditional Chinese medicine in treating obesity have attracted widespread attention and recognition. The ways of traditional Chinese medicine in treating obesity include diet therapy, traditional Chinese medicine, acupuncture and massage, etc. Traditional Chinese medicine mainly regulates lipid through the advantages of multiple targets and multiple sites, and the less adverse reactions and advantages of traditional Chinese medicine treatment provide a definite target for the research and production of weight loss drugs. SUMMARY

[0005] In view of the deficiencies in the prior art, the present application provides a traditional Chinese medicine composition for weight loss and blood lipid reduction with good efficacy, a preparation method thereof and uses thereof through a large number of experiments and clinical experience, which has less toxicity and side effects, and significant weight loss and lipid-lowering effect.

[0006] To solve the above technical problems, the technical scheme adopted by the present application is:

[0007] A traditional Chinese medicine composition for losing weight and reducing blood lipid, which is made of the following raw materials in parts by weight: Bai Zhi 10-20 parts, Dang Shen 10-20 parts, Tu Fu Ling 15-25 parts, Dan Shen 15-25 parts, Rou Fu Zhi Shu 5-15 parts, Rou Fu Yi Ren 15-25 parts, Chen Pi 10-20 parts, Fa Ban Xia 10-20 parts, Shan Zha 5-15 parts, Huang Lian Pian 15-25 parts, Chao Jue Ming Zi 15-25 parts, Rou Fu Cang Zhu 5-15 parts, Gan Jiang 5-15 parts, Xiao Tong Cao 2-8 parts.

[0008] Preferably, the traditional Chinese medicine composition is made of the following raw materials in parts by weight: Bai Zhi 12-18 parts, Dang Shen 12-18 parts, Tu Fu Ling 18-22 parts, Dan Shen 18-22 parts, Rou Fu Zhi Shu 8-12 parts, Rou Fu Yi Ren 18-22 parts, Chen Pi 12-18 parts, Fa Ban Xia 12-18 parts, Shan Zha 8-12 parts, Huang Lian Pian 18-22 parts, Chao Jue Ming Zi 18-22 parts, Rou Fu Cang Zhu 8-12 parts, Gan Jiang 8-12 parts, Xiao Tong Cao 4-6 parts.

[0009] Preferably, the traditional Chinese medicine composition is made of the following raw materials in parts by weight: Bai Zhi 15 parts, Dang Shen 15 parts, Tu Fu Ling 20 parts, Dan Shen 20 parts, Rou Fu Zhi Shu 10 parts, Rou Fu Yi Ren 20 parts, Chen Pi 15 parts, Fa Ban Xia 15 parts, Shan Zha 10 parts, Huang Lian Pian 20 parts, Chao Jue Ming Zi 20 parts, Rou Fu Cang Zhu 10 parts, Gan Jiang 10 parts, Xiao Tong Cao 5 parts.

[0010] Further, the present application also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps: weighing Bai Zhi, Chen Pi, Tu Fu Ling, Huang Lian Pian, Rou Fu Zhi Shu, Rou Fu Yi Ren and Rou Fu Cang Zhu respectively, crushing them to 100-150 meshes, mixing the crushed powders, adding 5-10 times of deionized water to decoct and extract 2-3 times, combining the extract and filtering, reducing and concentrating the filtrate to obtain extract 1; weighing Dang Shen, Fa Ban Xia, Shan Zha, Dan Shen, Chao Jue Ming Zi, Gan Jiang and Xiao Tong Cao respectively, crushing them to 100-150 meshes, mixing the crushed powders, adding 5-10 times of organic solvent to reflux and extract 2-3 times, combining the extract and filtering, reducing and concentrating the filtrate to obtain extract 2; drying and crushing extract 1 and extract 2, mixing them and passing through a 60-80 mesh sieve to obtain the traditional Chinese medicine composition in the form of extract dry powder.

[0011] Preferably, the organic solvent is 70-80% ethanol solution.

[0012] Preferably, the decocting and extracting time is 2-3 hours each time, and the extract obtained by concentrating the filtrate to 80℃ has a relative density of 1.15-1.25.

[0013] Preferably, the temperature of the organic solvent reflux extraction is 80℃, the extraction time is 1-2 hours, and the filtrate is concentrated to the extract with a relative density of 1.15-1.25 at 80℃.

[0014] Further, the present application also provides a pharmaceutical preparation consisting of the traditional Chinese medicine composition and a pharmaceutically acceptable carrier.

[0015] Preferably, the pharmaceutical preparation is water decoction, powder, oral liquid, pill, decoction, granule, capsule, ointment or tablet.

[0016] Further, the present application also provides the use of the traditional Chinese medicine composition in the preparation of a medicine for weight loss and blood lipid reduction.

[0017] Properties of each traditional Chinese medicine raw material:

[0018] Atractylodes rhizome: spleen and stomach meridians; invigorating spleen and qi, drying dampness and promoting water excretion; treating spleen deficiency, fatigue, poor appetite, abdominal distension, diarrhea, water retention, etc.

[0019] Codonopsis: spleen and lung meridians; invigorating spleen and lung, benefiting qi and generating fluid; treating spleen and stomach deficiency, poor appetite, diarrhea, limb weakness, lung deficiency, cough, shortness of breath, etc.

[0020] Smilax: liver, stomach and spleen meridians; clearing heat and removing dampness, removing turbidity and detoxifying, and freeing joints; treating syphilis, urinary tract infection, diarrhea, muscle and joint pain, beriberi, carbuncle, etc.

[0021] Salvia: heart, pericardium and liver meridians; promoting blood circulation, regulating menstruation and relieving pain, nourishing blood and calming the mind, cooling blood and eliminating carbuncle; treating irregular menstruation, dysmenorrhea, amenorrhea, postpartum abdominal pain, abdominal pain, hot arthralgia, trauma, hot blood into the blood, restlessness, insomnia, etc.

[0022] Bitter orange peel: spleen and lung meridians; regulating qi and invigorating spleen, drying dampness and resolving phlegm; treating abdominal pain due to stagnation of qi and food retention, constipation, diarrhea, and prolapse of the uterus and anus.

[0023] Bitter orange peel: spleen and lung meridians; regulating qi and invigorating spleen, drying dampness and resolving phlegm; treating abdominal pain due to stagnation of qi and food retention, constipation, diarrhea, and prolapse of the uterus and anus.

[0024] Bitter orange peel: spleen and lung meridians; regulating qi and invigorating spleen, drying dampness and resolving phlegm; treating abdominal pain due to stagnation of qi and food retention, constipation, diarrhea, and prolapse of the uterus and anus.

[0025] Bitter orange peel: spleen and lung meridians; regulating qi and invigorating spleen, drying dampness and resolving phlegm; treating abdominal pain due to stagnation of qi and food retention, constipation, diarrhea, and prolapse of the uterus and anus.

[0026] Hawthorn: spleen, stomach, liver, lung meridian; food accumulation, stagnation and stasis; treatment of food accumulation, abdominal pain, diarrhea, dysentery, etc.

[0027] Huanglian tablets: heart, liver, stomach, large intestine meridian; clear heat and fire, dryness, detoxification; treatment of high fever, restlessness, delirium or hot blood, nasal bleeding, wet heat, chest, diarrhea, dysentery, stomach vomiting or polyphagia, etc.

[0028] Fried cassia seed: liver, gallbladder, kidney meridian; dispel wind and clear heat, detoxification and dampness; treatment of wind heat, influenza, acute conjunctivitis, damp heat jaundice, acute and chronic nephritis, etc.

[0029] Bruised atractylodes: spleen, stomach, liver meridian; dry dampness and invigorate the spleen, expel wind and dampness, improve eyesight; treatment of dampness and spleen and stomach, lethargy, abdominal distension, anorexia, vomiting and diarrhea, phlegm, edema, etc.

[0030] Dried ginger: spleen, stomach, heart, lung meridian; warm the center and dispel cold, restore yang and unblock the vessels, warm the lungs and resolve dampness; treatment of cold pain in the abdomen, vomiting, diarrhea, yang deficiency, cold and dampness, etc.

[0031] Small Tong grass: lung, stomach meridian; clear heat, benefit water, and pass milk; treatment of hot fever, polydipsia, yellowish urine, oliguria or anuria, acute cystitis, nephritis, edema, and difficulty urinating.

[0032] Most of the obese patients are spleen deficiency and phlegm-dampness, which are mutually causal, but the accumulation of phlegm-dampness in the middle jiao is easy to generate heat, so the treatment should also pay attention to clearing heat and reducing dampness.

[0033] Compared with the prior art, the beneficial effects of the present application are: the traditional Chinese medicine composition of the present application is based on the theory of traditional Chinese medicine syndrome differentiation and treatment, and is reasonably formulated and combined to dry dampness and invigorate the spleen, regulate qi and resolve phlegm, and clear stomach fire. The method is as follows: prepared pinellia, atractylodes, codonopsis, and fried schisandra fruit are combined to invigorate the spleen and stomach, dry dampness and resolve phlegm, and regulate qi and stop vomiting; prepared pinellia is used with smilax, huanglian tablets, and fried atractylodes to dry dampness and resolve phlegm, and treat dampness and heat; pericarpium citri reticulatae regulates qi and invigorates the spleen, and codonopsis invigorates the spleen and the two drugs are used together to supplement and drain; pericarpium citri reticulatae is combined with smilax to invigorate the spleen and regulate qi, and the spleen and stomach are healthy; fried cassia seed and small Tong grass are used together to clear stomach fire and resolve phlegm and stagnation; fried yinyang rice and hawthorn are combined to resolve phlegm and dry dampness and regulate qi; and dan and dried ginger are combined to warm the interior and harmonize the stomach. When all the drugs are used together, the function of the spleen and stomach is restored to normal, dampness is dried, the spleen is invigorated, dampness and heat are both eliminated, and obesity is reduced. DETAILED DESCRIPTION

[0034] The technical solutions in the embodiments of the present application will be described clearly and completely below. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all the other embodiments obtained by those skilled in the art without creative work fall within the protection scope of the present application. The used materials, reagents, etc. are commercially available reagents and materials, unless otherwise specified.

[0035] Example 1: Chinese medicine composition for weight loss and blood lipid reduction

[0036] Prescription amount: Baizhu 15g, Dangshen 15g, Tufuling 20g, Danshen 20g, Fried Wu-Chi 10g, Fried Yiyiren 20g, Chenpi 15g, Fabanxia 15g, Shanzha 10g, Huanglian tablet 20g, Fried Juemingzi 20g, Fried Cangzhu 10g, Ganjiang 10g, Xiaotonghua 5g.

[0037] The preparation method of the traditional Chinese medicine composition comprises the following steps: respectively weighing Baizhu, Chenpi, Tufuling, Huanglian tablet, Fried Wu-Chi, Fried Yiyiren, and Fried Cangzhu, crushing to 100 meshes, mixing the crushed medicinal powder, adding 8 times amount of deionized water to decoct and extract 3 times, combining the extract liquid, filtering, and reducing pressure to concentrate the filtrate to obtain extract 1; respectively weighing Dangshen, Fabanxia, Shanzha, Danshen, Fried Juemingzi, Ganjiang, and Xiaotonghua, crushing to 100 meshes, mixing the crushed medicinal powder, adding 8 times amount of 75% ethanol solution to reflux extract 2 times, combining the extract liquid, filtering, and reducing pressure to concentrate the filtrate to obtain extract 2; drying and crushing the extract 1 and the extract 2, mixing and passing through a 60-mesh sieve to obtain the traditional Chinese medicine composition in the form of extract dry powder.

[0038] Example 2: Chinese medicine composition for weight loss and blood lipid reduction

[0039] Prescription amount: Baizhu 12g, Dangshen 18g, Tufuling 18g, Danshen 22g, Fried Wu-Chi 8g, Fried Yiyiren 22g, Chenpi 12g, Fabanxia 18g, Shanzha 8g, Huanglian tablet 22g, Fried Juemingzi 18g, Fried Cangzhu 12g, Ganjiang 8g, Xiaotonghua 6g.

[0040] The preparation method of the traditional Chinese medicine composition comprises the following steps: taking Astragalus root, prepared Pinellia, Fructus Crataegi, Salvia miltiorrhiza, fried Cassia obtusifolia, fried Coicis Semen, fried Atractylodes rhizome, respectively, crushing to 120 meshes, mixing the crushed medicinal material powder, adding 6 times amount of deionized water to decoct and extract twice, filtering the combined extract, and reducing pressure to concentrate the filtrate to obtain extract 1; taking Radix Codonopsis, prepared Rhizoma Pinelliae, Fructus Crataegi, Salvia miltiorrhiza, fried Cassia obtusifolia, dried ginger, and smallleaf globeflower, respectively, crushing to 120 meshes, mixing the crushed medicinal material powder, adding 10 times amount of 70% ethanol solution to reflux extract 3 times, filtering the combined extract, and reducing pressure to concentrate the filtrate to obtain extract 2; drying and crushing the extract 1 and the extract 2, mixing and filtering through a 70-mesh sieve, to obtain the traditional Chinese medicine composition in the form of extract dry powder.

[0041] Example 3: Chinese medicine composition for weight loss and blood lipid reduction

[0042] Prescription amount: Astragalus root 18g, prepared Pinellia 12g, Smilax 22g, Salvia miltiorrhiza 18g, fried Cassia obtusifolia 12g, fried Coicis Semen 18g, prepared Pinellia 18g, prepared Rhizoma Pinelliae 12g, Fructus Crataegi 12g, Salvia miltiorrhiza 18g, fried Cassia obtusifolia 8g, dried ginger 12g, and smallleaf globeflower 4g.

[0043] The preparation method of the traditional Chinese medicine composition comprises the following steps: taking Astragalus root, prepared Pinellia, Smilax, Salvia miltiorrhiza, fried Cassia obtusifolia, fried Coicis Semen, and fried Atractylodes rhizome, respectively, crushing to 120 meshes, mixing the crushed medicinal material powder, adding 10 times amount of deionized water to decoct and extract twice, filtering the combined extract, and reducing pressure to concentrate the filtrate to obtain extract 1; taking Radix Codonopsis, prepared Rhizoma Pinelliae, Fructus Crataegi, Salvia miltiorrhiza, fried Cassia obtusifolia, dried ginger, and smallleaf globeflower, respectively, crushing to 120 meshes, mixing the crushed medicinal material powder, adding 6 times amount of 80% ethanol solution to reflux extract twice, filtering the combined extract, and reducing pressure to concentrate the filtrate to obtain extract 2; drying and crushing the extract 1 and the extract 2, mixing and filtering through a 80-mesh sieve, to obtain the traditional Chinese medicine composition in the form of extract dry powder.

[0044] Comparative Example 1: Compared with Example 1, omitting two medicinal materials of Atractylodes macrocephala Koidz and Citrus reticulata

[0045] Prescription amount: Radix Codonopsis 15g, Smilax 20g, Salvia miltiorrhiza 20g, fried Cassia obtusifolia 10g, fried Coicis Semen 20g, prepared Rhizoma Pinelliae 15g, Fructus Crataegi 10g, Salvia miltiorrhiza 20g, fried Cassia obtusifolia 20g, fried Atractylodes rhizome 10g, dried ginger 10g, and smallleaf globeflower 5g.

[0046] The preparation method of the traditional Chinese medicine composition is the same as in Embodiment 1.

[0047] Comparative Example 2: Compared with Example 1, using Astragalus membranaceus instead of Radix Codonopsis and Magnolia officinalis instead of Smilax glabra

[0048] Prescription amount: Bai Zhi 15g, Huang Qi 15g, Hou Po 20g, Dan Shen 20g, Rou Fu Jia Shi 10g, Rou Fu Yi Ren 20g, Chen Pi 15g, Fa Ban Xia 15g, Shan Zha 10g, Huang Lian Pian 20g, Chao Jue Ming Zi 20g, Rou Fu Cang Zhu 10g, Gan Jiang 10g, Xiao Tong Cao 5g.

[0049] The preparation method of the traditional Chinese medicine composition is the same as that in Example 1.

[0050] Pharmacodynamic test

[0051] 1. Experimental animals

[0052] Ten normal female mice and 50 model female mice were selected. The modeling method is as follows: 80 three-week-old BALB / c female mice were adaptively fed for 7 days, and 70 mice were randomly selected and fed with high-fat feed for 10 weeks for modeling; the remaining 10 mice were the normal group and were fed with ordinary feed. The body weight of the mice was measured every week, and after 10 weeks, 50 mice with body weight higher than that of the normal group by more than 20% were randomly selected from the high-fat feed group as the model group.

[0053] 2. Preparation of prescription

[0054] The traditional Chinese medicine composition in the form of dry extract powder in Example 1 and Comparative Examples 1-2 was added to 50 times the amount of distilled water, heated and boiled for 1 hour, and continued to be boiled with warm fire until the concentration of the medicinal liquid was 0.6 g / mL. Orlistat was ground into powder and prepared into a medicinal liquid with a concentration of 0.01 g / mL with distilled water. The prepared medicinal liquid was stored in a brown glass bottle at 4°C.

[0055] 3. Animal grouping and drug intervention

[0056] Fifty model female mice with successful modeling were selected and randomly divided into five groups (i.e. model blank group, traditional Chinese medicine group in Example 1, traditional Chinese medicine group in Comparative Examples 1-2, and orlistat group), 10 mice in each group. The dosage of the traditional Chinese medicine group was 25.6 g / (kg·d), and the dosage of the orlistat group was 0.085 g / (kg·d). The mice in the above traditional Chinese medicine groups and orlistat group were given corresponding doses of drugs by gavage at regular times, and the normal group and the model blank group were given distilled water with corresponding volumes by gavage. The dosage during gavage was adjusted in real time according to the change of the body weight of the mice.

[0057] 4. Specimen collection and processing

[0058] Two hours after the end of gavage for 8 weeks, the mice were intraperitoneally injected with 1% pentobarbital, and blood was taken from the eyeball after anesthesia. The blood was left to stand at room temperature and centrifuged at 4°C and 5000 rpm for 5 min, and the supernatant was reserved and stored in a freezer at -20°C. The levels of TC, TG, HDL and LDL in the serum were detected by using a full-automatic biochemical analyzer.

[0059] 5. Statistical processing

[0060] The statistical software used in this experiment data is SPSS 19.0, and the results are presented in the form of mean ± standard deviation (x ± s). The comparison of samples between groups uses one-way analysis of variance, and the comparison of multi-factor samples between groups uses LSD method. The results are that when P < 0.05, it is considered that the difference has statistical significance.

[0061] 6. Experimental results

[0062] (1) Effect of the traditional Chinese medicine composition on the body weight of female mice

[0063] As shown in Table 1, the body weight data of female mice in each group was statistically analyzed. Before administration, the body weight of mice in the model blank group, the orlistat group, the traditional Chinese medicine group of Example 1 and the traditional Chinese medicine groups of Comparative Examples 1-2 had little difference (P > 0.05), but their body weight was higher than that of the normal group (P < 0.05). After 8 weeks of administration, compared with the model blank group, the body weight of mice in the traditional Chinese medicine group of Example 1, the traditional Chinese medicine groups of Comparative Examples 1-2 and the orlistat group decreased to a certain extent and the effect was significant (P < 0.05), among which the body weight of mice in the orlistat group and the traditional Chinese medicine group of Example 1 decreased more obviously than that in the traditional Chinese medicine groups of Comparative Examples 1-2 (P < 0.05). There was no significant difference in the body weight of mice between the orlistat group and the traditional Chinese medicine group of Example 1 (P > 0.05).

[0064] Table 1 Change of body weight of female mice

[0065]

[0066] Note: a P < 0.05 vs normal group (before administration); b P < 0.05 vs normal group (after administration); c P < 0.05 vs model blank group (after administration); d P < 0.05 vs orlistat group (after administration); e P < 0.05 vs traditional Chinese medicine group of Example 1 (after administration)

[0067] (2) Effect of the traditional Chinese medicine composition on the blood lipid of female mice

[0068] As shown in Table 2, compared with the normal group of mice, the contents of TC, TG and LDL in the serum of the model blank group of mice increased (P<0.05), and the content of HDL decreased (P<0.05). Compared with the model blank group, the contents of TC, TG and LDL in the orlistat group and the traditional Chinese medicine group of Example 1 decreased (P<0.05), and the content of HDL increased (P<0.05), and the change trend was more significant (P<0.05) compared with the traditional Chinese medicine groups of Comparative Examples 1-2. There was no significant difference (P>0.05) in the change of blood lipids of mice between the orlistat group and the traditional Chinese medicine group of Example 1.

[0069] Table 2 Change of blood lipids of female mice

[0070]

[0071] Note: a P<0.05 vs normal group; b P<0.05 vs model blank group; c P<0.05 vs orlistat group; d P<0.05 vs traditional Chinese medicine group of Example 1

[0072] 7. Result analysis

[0073] (1) Before administration, there was no significant difference in the body weight of mice among the obesity model group, the orlistat group and the three traditional Chinese medicine groups. After administration for 8 weeks, that is, when the mice were fed with high-fat feed until the end of the 18th week, compared with the normal diet group of mice, the body weight of the model blank group of mice increased significantly, and the body weight of the mice in each administration group decreased to different degrees compared with the body weight of the mice in the model blank group. Specifically, the body weight of the mice in the orlistat group and the traditional Chinese medicine group of Example 1 decreased more obviously, and the weight loss effect was obviously better than that of the traditional Chinese medicine groups of Comparative Examples 1-2 which were de-flavored or had flavor replaced. The above results show that the traditional Chinese medicine composition of the present application can effectively reduce energy intake, promote energy consumption and inhibit body weight gain.

[0074] (2) Studies have shown that long-term intake of high-fat diet can cause the body to develop dyslipidemia, leading to lipid metabolism disorder in the body, which is mainly manifested as the increase of triglyceride (TC), total cholesterol (TG) and low-density lipoprotein (LDL) in serum and liver, and the decrease of high-density lipoprotein (HDL). The detection results of blood lipids in this experiment showed that the levels of TC, TG and LDL in the serum of obese model mice were significantly higher than those of normal diet group mice, while the level of HDL was significantly decreased. Compared with the obese model group mice, the levels of TC, TG and LDL of orlistat group and traditional Chinese medicine group in Example 1 were decreased, and the level of HDL was increased, and the change trend was more significant compared with the traditional Chinese medicine group in Comparative Examples 1-2 which were de-flavored or replaced with medicine flavor. The above results showed that the traditional Chinese medicine composition of the present application could significantly improve the dyslipidemia of obese mice, and thus played a better role in improving lipid metabolism.

[0075] (3) In summary, the present application has obvious curative effect in weight loss and lipid reduction by reasonable compatibility of each traditional Chinese medicine raw material and optimization of preparation process, and has high clinical application value. The combination of various drugs can restore the normal function of spleen and stomach, remove dampness and heat, and reduce obesity with high safety and no toxic side effects.

[0076] The above description is only the preferred embodiments of the present application, and it should be pointed out that for ordinary skilled in the art, without departing from the principles of the present application, the technical solutions can also be modified or replaced by equivalent, and these modifications or equivalent replacements should also be considered as the protection scope of the present application.

Claims

1. A traditional Chinese medicine composition for weight loss and blood lipid reduction, characterized in that: The traditional Chinese medicine composition is made of the following raw materials in parts by weight: Baizhu 10-20 parts, Dangshen 10-20 parts, Tufuling 15-25 parts, Danshen 15-25 parts, Fried Citrus aurantium 5-15 parts, Fried Semen coicis 15-25 parts, Chenpi 10-20 parts, Fabaizhi 10-20 parts, Shanzha 5-15 parts, Huanglian 15-25 parts, Fried Cassia obtusifolia 15-25 parts, Fried Atractylodes 5-15 parts, Ganjiang 5-15 parts, Xiaotonghua 2-8 parts. ​ 2. The traditional Chinese medicine composition according to claim 1, characterized in that: The traditional Chinese medicine composition is made of the following raw materials in parts by weight: Baizhu 12-18 parts, Dangshen 12-18 parts, Tufuling 18-22 parts, Danshen 18-22 parts, Fried Citrus aurantium 8-12 parts, Fried Semen coicis 18-22 parts, Chenpi 12-18 parts, Fabaizhi 12-18 parts, Shanzha 8-12 parts, Huanglian 18-22 parts, Fried Cassia obtusifolia 18-22 parts, Fried Atractylodes 8-12 parts, Ganjiang 8-12 parts, Xiaotonghua 4-6 parts.

3. The traditional Chinese medicine composition according to claim 2, characterized in that: The traditional Chinese medicine composition is made of the following raw materials in parts by weight: Baizhu 15 parts, Dangshen 15 parts, Tufuling 20 parts, Danshen 20 parts, Fried Citrus aurantium 10 parts, Fried Semen coicis 20 parts, Chenpi 15 parts, Fabaizhi 15 parts, Shanzha 10 parts, Huanglian 20 parts, Fried Cassia obtusifolia 20 parts, Fried Atractylodes 10 parts, Ganjiang 10 parts, Xiaotonghua 5 parts.

4. The preparation method of the traditional Chinese medicine composition according to any one of claims 1-3, characterized in that, The method comprises the following steps: separately weighing Baizhu, Chenpi, Tufuling, Huanglian, Fried Citrus aurantium, Fried Semen coicis, and Fried Atractylodes, and crushing them to 100-150 meshes; mixing the crushed powders of the medicinal materials, and adding 5-10 times of deionized water to decoct and extract 2-3 times; combining the extractives, filtering, and reducing the pressure to concentrate the filtrate to obtain extract 1; separately weighing Dangshen, Fabaizhi, Shanzha, Danshen, Fried Cassia obtusifolia, Ganjiang, and Xiaotonghua, and crushing them to 100-150 meshes; mixing the crushed powders of the medicinal materials, and adding 5-10 times of 70-80% ethanol solution to reflux extract 2-3 times; combining the extractives, filtering, and reducing the pressure to concentrate the filtrate to obtain extract 2; drying and crushing the extract 1 and the extract 2, mixing, and passing through a 60-80 mesh sieve to obtain the traditional Chinese medicine composition in the form of extract dry powder.

5. The production method according to claim 4, characterized by, The decocting and extracting is performed for 2-3 hours each time, and the filtrate is concentrated to an extract with a relative density of 1.15-1.25 at 80°C.

6. The preparation method according to claim 4, characterized in that, The reflux extracting is performed at a temperature of 80°C for 1-2 hours each time, and the filtrate is concentrated to an extract with a relative density of 1.15-1.25 at 80°C.

7. A pharmaceutical preparation, characterized by, The traditional Chinese medicine composition of any one of claims 1-3 and a pharmaceutically acceptable carrier.

8. The pharmaceutical preparation according to claim 7, characterized in that, The pharmaceutical preparation is a decoction, a powder, an oral liquid, a pill, a soup, a granule, a capsule, a plaster, or a tablet.

9. Use of the traditional Chinese medicine composition of any one of claims 1-3 or prepared by the preparation method of any one of claims 4-6 in the preparation of a drug for weight loss and blood lipid reduction.

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