Composition for improving fat metabolism and inhibiting fat formation, preparation method and application thereof

Abstract

The present invention provides a composition, preparation method and application for improving fat metabolism and inhibiting fat formation, and relates to the field of food technology. The present invention reasonably matches L-carnitine, L-arabinose, epigallocatechin gallate, soybean peptide and plant materials, wherein the plant materials include citrus cinnamon composite powder, ginseng powder and longan powder, and each component is compounded with each other, and the prepared composition has the effect of significantly promoting fatty acid metabolism and inhibiting fat, and has a strong heating sensation after consuming the composition of the present invention. The preparation method of the composition of the present invention is simple, and the composition is applied to food, which has the effect of improving fatty acid metabolism and significantly inhibiting fat formation.

Description

Technical Field

[0001] The present invention specifically relates to a composition for improving fat metabolism and inhibiting fat formation, and a preparation method and application thereof. Background Art

[0002] L-carnitine, chemically known as (R)-3-carboxyl-2-hydroxy-N,N,N-trimethylpropylammonium hydroxide inner salt, is hygroscopic, has good water solubility and water absorption, and is resistant to high temperatures. L-carnitine is an amino acid-like substance that is essential for body fat metabolism. It can promote fat conversion and has no adverse reactions to the human body.

[0003] L-carnitine is also an essential auxiliary factor for fat metabolism. It has many functions such as oxidative decomposition of fat, fatigue relief, and weight loss. L-carnitine can also improve exercise mood, enhance body vitality, and increase muscle endurance and exercise capacity. Long-chain fatty acids are the main components of fat. When metabolized in the human body, they enter the veins through the lymphatic vessels in the form of triglycerides, are transported and stored in various tissues of the human body, and easily accumulate to form fat. The main mechanism of action of L-carnitine is to promote β-oxidation of fatty acids, and it plays a key role in the decomposition of fatty acids.

[0004] Lack of L-carnitine in the body can lead to fat metabolism disorders, causing fat substances to accumulate in muscle fibers and liver, and then causing obesity and fatty liver. The human body mainly takes in L-carnitine through two ways: one is dietary sources, supplementing L-carnitine by consuming red meat products, but the intake of this way is closely related to eating habits; the other way is through the body's own synthesis to meet physiological needs, but this synthesis is very limited. The most ideal level of L-carnitine intake cannot be achieved by human synthesis and ordinary dietary sources alone. Therefore, additional L-carnitine supplementation is needed to achieve the effect of controlling weight and inhibiting fat.

[0005] At present, L-carnitine is used by the body as a single material raw material to convert fat into energy and thus promote energy consumption. However, simply promoting energy consumption cannot fully exert the functional characteristics of L-carnitine, and cannot enable it to effectively participate in the body's fat formation or the fatty acid metabolism pathway.

[0006] The products containing L-carnitine provided by the prior art have a weak sense of heating after consumption, a limited weight loss effect, and are prone to rebound after weight loss. Therefore, the present invention provides a composition for improving fat metabolism and inhibiting fat formation and a preparation method thereof, wherein L-carnitine is reasonably matched with L-arabinose and plant materials, and the obtained composition can not only significantly promote fatty acid metabolism and inhibit fat, but also bring a strong sense of heating after consumption, thereby improving the fat burning effect. Summary of the invention

[0007] In view of the problems existing in the prior art, the present invention provides a composition for improving fat metabolism and inhibiting fat formation, as well as a preparation method and application thereof. L-carnitine, L-arabinose, epigallocatechin gallate, soybean peptide and plant materials are reasonably matched, wherein the plant materials include citrus cinnamon composite powder, ginseng powder and longan powder. The prepared composition has the effect of inhibiting fat formation and brings a strong sense of heating after consumption.

[0008] To achieve the above purpose, the technical solution adopted by the present invention is as follows:

[0009] First, the present invention provides a composition for improving fat metabolism and inhibiting fat formation, which comprises the following components by weight: 40-51 parts of L-carnitine, 0.8-3 parts of citrus cinnamon composite powder, 10-16 parts of L-arabinose, 2-6 parts of epigallocatechin gallate, 7-15 parts of soybean peptide, 2-5 parts of ginseng powder and 1-4 parts of piperine powder;

[0010] The ginseng powder is ginseng powder containing ginsenoside Rb1, and the content of ginsenoside Rb1 is 10-15%.

[0011] Preferably, the composition comprises the following components in parts by weight: 43-46.7 parts of L-carnitine, 1.5-2.5 parts of citrus cinnamon composite powder, 13-15.6 parts of L-arabinose, 3-5.2 parts of epigallocatechin gallate, 8-12 parts of soybean peptide, 2.5-4 parts of ginseng powder and 2.5-3.6 parts of piperine powder.

[0012] Further preferably, the composition comprises the following components, in parts by weight: 45.5 parts of L-carnitine, 2 parts of citrus cinnamon composite powder, 15 parts of L-arabinose, 4 parts of epigallocatechin gallate, 10 parts of soybean peptide, 3 parts of ginseng powder and 3 parts of piperine powder.

[0013] Preferably, the weight ratio of the citrus cinnamon composite powder, epigallocatechin gallate, ginseng powder and piper longum powder is 1.5-2.5:3-5.2:2.5-4:2.5-3.6; further preferably, the weight ratio of the citrus cinnamon composite powder, epigallocatechin gallate, ginseng powder and piper longum powder is 2:4:3:3.

[0014] Preferably, the content of ginsenoside Rb1 is 10%.

[0015] Preferably, the citrus cinnamon composite powder comprises active ingredients: hesperidin and cinnamaldehyde; the content of hesperidin is 0.3-0.6%, and the content of cinnamaldehyde is 0.5-1.5%.

[0016] Further preferably, in the citrus cinnamon composite powder, the content of hesperidin is 0.5%, and the content of cinnamaldehyde is 1%.

[0017] Then, the present invention provides a method for preparing the above composition, comprising the steps of:

[0018] (1) Mixing citrus cinnamon composite powder, ginseng powder and piper longum powder to obtain composite plant powder;

[0019] (2) mixing L-arabinose, epigallocatechin gallate and soybean peptide to obtain functional material powder;

[0020] (3) Mixing the composite plant powder, the functional material powder and L-carnitine to obtain a composition.

[0021] Preferably, in step (1) to step (3), the mixing is carried out at room temperature and stirred at 100-200 rpm for 5-15 minutes until the mixture is uniformly stirred.

[0022] In the present invention, L-carnitine is used as a carrier to transport medium- and long-chain fatty acids from outside the mitochondrial membrane to inside the membrane in the form of acylcarnitine, and β-oxidation is performed in the mitochondria, thereby achieving the effect of degrading fat; in addition, L-carnitine also promotes the tricarboxylic acid cycle to produce adenosine triphosphate, and assists cells in completing normal physiological functions and energy metabolism.

[0023] In the present invention, epigallocatechin gallate has the physiological function of inhibiting the activity of fatty acid oxygenase. Fatty acid oxygenase is an important enzyme in the process of fat synthesis in biological cells. Controlling the activity of fatty acid oxygenase is an effective method for controlling body fat.

[0024] In the present invention, there is a synergistic effect between the ingredients such as L-carnitine, citrus cinnamon composite powder, epigallocatechin gallate, soybean peptide, ginseng powder and longan powder, and the composition fully exerts its effect of promoting fatty acid metabolism. After consuming the composition of the present invention, there is an obvious feeling of fever.

[0025] Compared with the prior art, the present invention has the following beneficial effects:

[0026] 1. In the composition of the present invention, the various ingredients cooperate with each other and complement each other. L-carnitine accelerates fatty acid metabolism, and the citrus cinnamon composite powder, epigallocatechin gallate, longan powder and ginseng powder containing ginsenoside Rb1 interact with each other to inhibit the activity of fatty acid oxygenase, thereby achieving a significant effect of weight loss and fat reduction.

[0027] 2. In the composition of the present invention, the addition of soybean peptides can not only strengthen the nutritional system of the composition, but also the soybean peptides are reasonably matched with L-carnitine and other ingredients, so that the functional characteristics of each ingredient can be maximized, fatty acid metabolism can be promoted, and fat formation can be inhibited.

[0028] 3. The composition of the present invention can promote energy consumption, has an obvious heating sensation, and achieves the purpose of rapid weight and fat reduction. DETAILED DESCRIPTION

[0029] The following non-limiting examples can enable those skilled in the art to more fully understand the present invention, but do not limit the present invention in any way. The following content is merely an exemplary description of the scope of the present invention, and those skilled in the art can make various changes and modifications to the present invention based on the disclosed content, which should also fall within the scope of the present invention.

[0030] When the embodiments give numerical ranges, it should be understood that, unless otherwise specified in the present invention, both endpoints of each numerical range and any numerical value between the two endpoints can be selected. Unless otherwise defined, all technical and scientific terms used in the present invention have the same meanings as those generally understood by those of ordinary skill in the art to which the present invention belongs.

[0031] The present invention is further described below by way of specific examples. The various chemical reagents used in the examples of the present invention are obtained through conventional commercial channels unless otherwise specified. For the following components, products from different manufacturers have no significant effect on the effects.

[0032] In the following embodiments, the citrus cinnamon composite powder contains 0.5% hesperidin and 1% cinnamaldehyde (dry basis); the relative molecular mass of the soybean peptide (dry basis) ≥80% peptide segment is ≤2000, and the peptide content is 86.17g / 100g on a dry basis; in the ginseng powder, the content of ginsenoside Rb1 is 10%-15%.

[0033] Example 1-Example 5

[0034] A composition for reducing weight and inhibiting fat formation, the components of which are shown in Table 1 by weight:

[0035] Table 1

[0036]

[0037] The citrus cinnamon composite powder in Table 1 contains 0.5% hesperidin and 1% cinnamaldehyde; the ginseng powder is rich in ginsenoside Rb1, and the content of ginsenoside Rb1 is 10%.

[0038] The preparation method of the composition of Example 1-Example 5 is:

[0039] (1) stirring the citrus cinnamon composite powder, ginseng powder and piper longum powder at 150 rpm for 10 min to obtain a composite plant powder;

[0040] (2) L-arabinose, epigallocatechin gallate and soybean peptide were stirred at 150 rpm for 10 min to mix evenly to obtain functional material powder;

[0041] (3) The composite plant powder, functional material powder and L-carnitine were stirred at 150 rpm for 5 min to mix evenly to obtain a composition.

[0042] Comparative Example 1

[0043] Different from Example 1, the composition does not contain citrus cinnamon composite powder.

[0044] The composition consists of the following components in parts by weight: 45.5 parts of L-carnitine, 15 parts of L-arabinose, 4 parts of epigallocatechin gallate, 10 parts of soybean peptide, 3 parts of ginseng powder and 3 parts of piper longum powder.

[0045] The preparation method is:

[0046] (1) Stirring ginseng powder and piper longum powder at 150 rpm for 10 min to mix evenly to obtain composite plant powder;

[0047] (2) L-arabinose, epigallocatechin gallate and soybean peptide were stirred at 150 rpm for 10 min to mix evenly to obtain functional material powder;

[0048] (3) The composite plant powder, functional material powder and L-carnitine were stirred at 150 rpm for 5 min to mix evenly to obtain a composition.

[0049] Comparative Example 2

[0050] Different from Example 1, the composition does not contain the component epigallocatechin gallate.

[0051] The composition is composed of the following components in parts by weight: 45.5 parts of L-carnitine, 2 parts of citrus cinnamon composite powder, 15 parts of L-arabinose, 10 parts of soybean peptide, 3 parts of ginseng powder and 3 parts of piper longum powder.

[0052] The preparation method is:

[0053] (1) stirring the citrus cinnamon composite powder, ginseng powder and piper longum powder at 150 rpm for 10 min to obtain a composite plant powder;

[0054] (2) stirring L-arabinose and soybean peptide at 150 rpm for 10 min to mix evenly to obtain functional material powder;

[0055] (3) The composite plant powder, functional material powder and L-carnitine were stirred at 150 rpm for 5 min to mix evenly to obtain a composition.

[0056] Comparative Example 3

[0057] Different from Example 1, the composition does not contain Piper longum powder.

[0058] The composition consists of the following components in parts by weight: 45.5 parts of L-carnitine, 2 parts of citrus cinnamon composite powder, 15 parts of L-arabinose, 4 parts of epigallocatechin gallate, 10 parts of soybean peptide and 3 parts of ginseng powder.

[0059] The preparation method is:

[0060] (1) stirring the citrus cinnamon composite powder and ginseng powder at 150 rpm for 10 minutes to mix evenly to obtain composite plant powder;

[0061] (2) L-arabinose, epigallocatechin gallate and soybean peptide were stirred at 150 rpm for 10 min to mix evenly to obtain functional material powder;

[0062] (3) The composite plant powder, functional material powder and L-carnitine were stirred at 150 rpm for 5 min to mix evenly to obtain a composition.

[0063] Comparative Example 4

[0064] Different from Example 1, the composition only contains the following components: citrus cinnamon composite powder, L-arabinose, epigallocatechin gallate and piper longum powder.

[0065] The composition consists of the following components in parts by weight: 2 parts of citrus cinnamon composite powder, 15 parts of L-arabinose, 4 parts of epigallocatechin gallate and 3 parts of piper longum powder.

[0066] The preparation method of the composition of Example 1-Example 5 is:

[0067] (1) stirring the citrus cinnamon composite powder and the piper longum powder at 150 rpm for 10 min to mix evenly to obtain a composite plant powder;

[0068] (2) stirring L-arabinose and epigallocatechin gallate at 150 rpm for 10 min to mix evenly to obtain a functional material powder;

[0069] (3) The composite plant powder and the functional material powder were stirred at 150 rpm for 5 min to mix evenly to obtain a composite material.

[0070] Comparative Example 5

[0071] Different from Example 1, the composition only contains the following components: L-carnitine, soybean peptide and ginseng powder.

[0072] The composition consists of the following components in parts by weight: 45.5 parts of L-carnitine, 10 parts of soybean peptide and 3 parts of ginseng powder.

[0073] The preparation method is:

[0074] (1) Stirring the ginseng powder at 150 rpm for 10 min to mix evenly to obtain plant powder;

[0075] (2) Stir the soybean peptide at 150 rpm for 10 min to mix evenly to obtain functional material powder;

[0076] (3) The plant powder, functional material powder and L-carnitine were stirred at 150 rpm for 5 minutes to mix evenly to obtain a composition.

[0077] Comparative Example 6

[0078] The difference from Example 1 is that the content of active ingredients in the citrus cinnamon composite powder in the composition is different. In the citrus cinnamon composite powder of this comparative example, the content of hesperidin is 1.3%, and the content of cinnamaldehyde is 0.2%.

[0079] The preparation method is the same as that of Example 1.

[0080] Comparative Example 7

[0081] Different from Example 1, ginsenoside Rb1 in ginseng powder is replaced by ginsenoside CK (20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol).

[0082] The preparation method is the same as that of Example 1.

[0083] Comparative test 1

[0084] Healthy adult male rats were selected and randomly divided into 13 groups according to their weight levels, namely, Example 1-Example 5 groups, obesity model groups, Comparative Examples 1-Comparative Examples 7 groups, with 5 animals in each group. Each group was fed with a high-fat diet to form a high-fat diet-induced dietary obesity model. Then a weight loss intervention experiment was carried out, and the obesity model group was used as a control group, with a normal diet and gavage of deionized water. In addition to a normal diet, the remaining groups were gavaged with the compositions of each embodiment and comparative example according to the dose, and the composition was prepared as a liquid, and the mass concentration of the composition in the liquid was 10%; both the embodiment and comparative example groups were gavaged at 2.0 mL / 100 g for 1 month, gavage once a day. Fasting for 16 hours before the end of the experiment, decapitation after weighing, and dissection to weigh the abdominal testicles and perirenal fat.

[0085] The results of rat body weight and visceral fat coefficient are shown in Table 2.

[0086] Table 2

[0087]

[0088] The letters a, b, c, and d in Table 2 represent the results of significant differences: between the same column and different rows, the same letters indicate no significant difference (P>0.05), and different letters indicate significant difference (P<0.05).

[0089] As can be seen from Table 2, in terms of weight control, Examples 1 to 5 can significantly reduce the weight of obese rats compared to the control example, among which the negative weight growth of Example 1 is the most obvious; this indicates that feeding the composition of the present invention to rats can significantly improve the fatty acid metabolism of rats and inhibit the formation of fat; this can also be well explained from the visceral fat coefficient results.

[0090] Comparative test 2

[0091] 1. Experimental samples

[0092] Compositions of Examples 1 to 3, Comparative Examples 1, 4, 5 and 6. 3.0 g of the above composition was prepared with 90-95° C. water to prepare 25 mL of a liquid solution.

[0093] The prepared liquid solution is clear and transparent, has no precipitation, no flocculation, and has a good taste.

[0094] 2. Experimental methods

[0095] Subject standards: age distribution is 20-35 years old, gender ratio is 1:1, female weight distribution is 100±3kg; male weight distribution is 130±3kg.

[0096] The required energy was calculated based on the subject's age, height and standard weight. In the first month, 100% of the daily energy and various nutrients were provided according to the recommended supply of the Chinese Nutrition Society. In the second and third months, 90% of the recommended energy supply was provided, and the total daily energy did not exceed 11.72MJ / d. The energy supply ratio of the three major nutrients was 20% of the total energy from protein, 30% from fat, and 50% from carbohydrates.

[0097] The amount of exercise is: concentrated walking 5 times a week, 60 minutes each time.

[0098] Experimental method: 4 subjects (2 males + 2 females) in each group drank the experimental sample once a day for 3 consecutive months. The initial and third month body weights were recorded. The results are shown in Table 3.

[0099] Table 3

[0100]

[0101] As can be seen from Table 3, the subjects who consumed the composition of Example 1 had a good weight loss situation, and there was a certain difference in weight (p < 0.05). In terms of the subject's physical feedback report, the physical sensation of Example 1 was stronger, and the subjects who consumed the compositions of Examples 1 to 3 all felt a fever, without adverse reactions. After consuming the compositions of Comparative Examples 4 and 5, the physical sensation was weaker. The composition of the present invention can improve fatty acid metabolism and inhibit fat formation, bringing about a significant weight loss effect.

[0102] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, rather than to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions of the technical solution of the present invention by ordinary technicians in this field do not deviate from the essence and scope of the technical solution of the present invention.

Claims

1. A composition for improving fat metabolism and inhibiting fat formation, characterized in that: The composition comprises the following components by weight: 40-51 parts of L-carnitine, 0.8-3 parts of citrus cinnamon compound powder, 10-16 parts of L-arabinose, 2-6 parts of epigallocatechin gallate, 7-15 parts of soybean peptide, 2-5 parts of ginseng powder and 1-4 parts of piperine powder; The ginseng powder is ginseng powder containing ginsenoside Rb1, and the content of ginsenoside Rb1 is 10-15%; The citrus cinnamon composite powder comprises active ingredients: hesperidin and cinnamaldehyde; the content of hesperidin is 0.3-0.6%, and the content of cinnamaldehyde is 0.5-1.5%.

2. The composition according to claim 1, characterized in that Calculated by weight, the invention comprises the following components: 43-46.7 parts of L-carnitine, 1.5-2.5 parts of citrus cinnamon compound powder, 13-15.6 parts of L-arabinose, 3-5.2 parts of epigallocatechin gallate, 8-12 parts of soybean peptide, 2.5-4 parts of ginseng powder and 2.5-3.6 parts of piperine powder.

3. The composition according to claim 2, characterized in that Calculated by weight, the invention comprises the following components: 45.5 parts of L-carnitine, 2 parts of citrus cinnamon compound powder, 15 parts of L-arabinose, 4 parts of epigallocatechin gallate, 10 parts of soybean peptide, 3 parts of ginseng powder and 3 parts of piperine powder.

4. The composition according to claim 1, characterized in that The weight ratio of the citrus cinnamon composite powder, epigallocatechin gallate, ginseng powder and piper longum powder is 1.5-2.5:3-5.2:2.5-4:2.5-3.

6.

5. The composition according to claim 4, characterized in that The weight ratio of the citrus cinnamon composite powder, epigallocatechin gallate, ginseng powder and piper longum powder is 2:4:3:

3.

6. The composition according to claim 1, characterized in that The content of ginsenoside Rb1 is 10%.

7. The composition according to claim 1, characterized in that In the citrus cinnamon composite powder, the content of hesperidin is 0.5%, and the content of cinnamaldehyde is 1%.

8. The method for preparing the composition according to any one of claims 1 to 7, characterized in that: Includes steps: (1) Mixing citrus cinnamon composite powder, ginseng powder and piper longum powder to obtain composite plant powder; (2) mixing L-arabinose, epigallocatechin gallate and soybean peptide to obtain functional material powder; (3) Mixing the composite plant powder, the functional material powder and L-carnitine to obtain a composition.

Images