A piperazine-1-methylindole-2-carboxamide derivative, its preparation method and application

Abstract

The present invention discloses a piperazine-1-methylindole-2-formamide derivative, a preparation method and an application thereof, and belongs to the field of drug synthesis. The piperazine-1-methylindole-2-formamide derivative structural formula is shown in general formula I: wherein R1 is selected from n=1,2,3,4,5,6,7,8,9,10. The biologically active piperazine-1-methylindole-2-formamide nucleus group contained therein is further chemically modified to produce many biologically more active compounds, which expands the wide application of such compounds in biomedicine and the development prospects of pharmaceutical preparations. Such compounds can significantly inhibit the proliferation of cells such as breast cancer, liver cancer, pancreatic cancer, gastric cancer, lung cancer, esophageal cancer, cervical cancer, multiple myeloma, diffuse large B-cell lymphoma at low doses (nanomolar), and can effectively inhibit STAT3 protein phosphorylation, indicating that such compounds have the prospect of being developed as anti-tumor drugs.

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