A tea substitute for reducing uric acid and assisting in the treatment of gout and a preparation method thereof

Abstract

The invention discloses a tea substitute for reducing uric acid and assisting in the treatment of gout, comprising by weight: 55-90 parts of black tea, 12-18 parts of Codonopsis pilosula, 12-18 parts of Smilax glabra, 12-18 parts of water flos floridis, 12-18 parts of Hibiscus mutabilis leaves, 8-12 parts of corn silk, 8-12 parts of dandelion, 8-12 parts of Momordica grosvenori, 5-10 parts of hawthorn, 5-10 parts of yam, 3-8 parts of wolfberry, 3-8 parts of Eucommia ulmoides, and 2-5 parts of Sargassum polysaccharide. The Chinese medicinal ingredients are reasonably matched according to the monarch, minister, assistant and envoy theory, Sargassum polysaccharide has certain viscosity, stability and antioxidant properties, helps to maintain the physical properties and texture stability of the product, and the black tea base is compounded with a variety of Chinese herbal medicines and Sargassum polysaccharide for taking, has good uric acid reduction and inhibitory effects, and can be used for assisting the prevention and treatment of gout.

Description

Technical Field

[0001] The invention relates to the technical field of Chinese medicinal tea preparations, and in particular to a tea substitute for reducing uric acid and assisting in the treatment of gout and a preparation method thereof. Background Art

[0002] Gout is a disease caused by excessive deposition of uric acid. The incidence of gout is distributed worldwide and is affected by region, ethnicity and eating habits. In China, the prevalence of gout is about 1%-3%. With the extension of the average life expectancy of humans and changes in diet and lifestyle, this data has been increasing year by year. The basic cause and specific pathogenesis of gout are not very clear, but gout is closely related to hyperuricemia. About 90% of patients are caused by uric acid excretion disorders. Uric acid is a waste product produced when the human body metabolizes purine. Under normal circumstances, uric acid is excreted from the body through the kidneys; but when uric acid is produced too much or excreted insufficiently, the uric acid level in the blood will increase, forming uric acid crystals that are deposited in the joints and soft tissues, causing inflammation and pain. Frequent acute joint pain, as well as redness, swelling, heat, pain and dysfunction around the joints are typical symptoms of gout. Repeated attacks of the disease can lead to chronic joint lesions, which will eventually change the joint morphology and limit joint movement. Patients may also suffer from kidney damage when the disease lasts for a long time.

[0003] The treatment of gout includes timely control and relief of acute joint inflammation, prevention of further deposition of uric acid in tissues by lowering blood uric acid levels, and prevention of uric acid crystal formation and reduction of severe damage to joints and kidney function. Currently available drug treatments usually help reduce uric acid levels in the body by increasing urine excretion, thereby reducing the chance of gout attacks, but long-term use of diuretics may lead to electrolyte imbalance. There are also drugs such as allopurinol and febuxostat that can inhibit the synthesis of uric acid, help lower uric acid levels, and reduce gout attacks, but long-term use may cause abnormal liver function or other adverse reactions.

[0004] Compared with Western medicine treatment, Chinese herbal tea substitutes may reduce some adverse reactions and side effects, especially for patients who take it for a long time or need auxiliary treatment. This is particularly important. Tea substitutes, also known as medicine instead of tea. Choose one or two or several Chinese herbal medicines (usually ground into coarse powder) to decoct or brew with boiling water for a few minutes, then drink it slowly instead of tea. Therefore, it is very necessary to study a tea substitute with significant effect in lowering uric acid for the prevention and treatment of gout. Summary of the invention

[0005] In view of this, the present invention proposes a tea substitute for reducing uric acid and assisting in the treatment of gout and a preparation method thereof to solve the above problems.

[0006] The technical solution of the present invention is achieved in this way:

[0007] A tea substitute for lowering uric acid and assisting in the treatment of gout comprises, by weight: 55-90 parts of black tea, 12-18 parts of codonopsis pilosula, 12-18 parts of smilax glabra, 12-18 parts of water lily, 12-18 parts of hibiscus leaves, 8-12 parts of corn silk, 8-12 parts of dandelion, 8-12 parts of momordica grosvenori, 5-10 parts of hawthorn, 5-10 parts of yam, 3-8 parts of wolfberry, 3-8 parts of eucommia bark, and 2-5 parts of sargassum polysaccharide.

[0008] Preferably, the tea substitute for lowering uric acid and assisting in the treatment of gout comprises, by weight: 75 parts of black tea, 15 parts of Codonopsis pilosula, 15 parts of Smilax glabra, 15 parts of Water Chestnut, 15 parts of Hibiscus mutabilis leaves, 10 parts of Corn Silk, 10 parts of Dandelion, 10 parts of Momordica grosvenori, 8 parts of Hawthorn, 8 parts of Chinese Yam, 5 parts of Lycium barbarum, 5 parts of Eucommia ulmoides, and 3 parts of Sargassum polysaccharide.

[0009] A method for preparing a tea substitute for reducing uric acid and assisting in the treatment of gout comprises the following steps:

[0010] S1. Decoction: Take the required black tea and Chinese medicinal materials by weight, add water to decoct, filter, concentrate and cool;

[0011] S2, alcohol extraction: add ethanol to the concentrated solution cooled in step S1, filter and concentrate;

[0012] S3, adding Sargassum polysaccharide to the filtrate of S2, mixing evenly, spray drying, and ultrafine grinding into fine powder;

[0013] S4. Vacuum drying to remove solvent residues, ultraviolet disinfection, and packaging into bags.

[0014] Preferably, after filtering in S1, the filtrate is concentrated to a relative density of 1.05-1.1.

[0015] Preferably, the amount of ethanol used in S2 is 3-5 times the volume of the concentrated liquid after cooling; and the filtrate after filtration is concentrated to a relative density of 1.15-1.2.

[0016] Preferably, the vacuum drying temperature is 45-55° C., the pressure is -0.05 MPa, and the drying time is 2-3 hours; and the moisture content of the fine powder after drying does not exceed 2%.

[0017] Preferably, the ultrafine grinding speed is 2000-3000r / min, the time is 1-2h, and the fine powder particle size is 10-20μm.

[0018] Black tea is the young leaves or buds of the tea plant of the family Theaceae. Black tea is not grown naturally, but is made from new leaves of suitable tea trees, which are refined through a series of processes such as withering, rolling (cutting), fermentation, and drying. The fermentation process causes the ingredients in the tea to react chemically, and when brewed with water, it not only has a pleasant aroma, but also presents a unique dark red tea color, so it is called "black tea".

[0019] Codonopsis pilosula, a Chinese medicine, is the dried root of Codonopsis pilosula (Franch.) Nannf., ...

[0020] Tu Fuling, a Chinese medicine, is the dried rhizome of Smilax glabra Roxb., a plant of the Liliaceae family. It tastes sweet and light, is neutral in nature, and has the effects of detoxification, dehumidification, and joint relaxation.

[0021] Hibiscus mutabilis Linn., a Chinese medicine, is the leaf of Hibiscus mutabilis Linn., a plant of the Malvaceae family. It is spicy and neutral in nature, and has the effects of cooling blood, detoxifying, reducing swelling, and relieving pain.

[0022] Adinapilulifera, a Chinese medicine, is the leaves, flowers or fruits of Adinapilulifera (Lam.) Franch.ex Drake, a plant of the Rubiaceae family. It tastes bitter and astringent, is cool in nature, and has the effects of clearing away heat and dampness, dispersing blood stasis and relieving pain, and stopping bleeding and healing sores.

[0023] Corn silk, a Chinese medicine, is the style and stigma of Zea mays L., a grass plant. It tastes sweet and light, is neutral in nature, and has the effects of diuresis and swelling, as well as clearing the liver and promoting bile secretion.

[0024] Dandelion, a Chinese medicine, is the dried whole herb of Taraxacum mongolicum Hand.-Mazz., Taraxacumborealisinense Kitag. or several plants of the same genus. It tastes bitter and sweet, is cold in nature, and has the effects of clearing away heat and detoxifying, reducing swelling and dispersing stagnation, and promoting diuresis and relieving stranguria.

[0025] Luo Han Guo, a Chinese medicine name, is the dried fruit of the Cucurbitaceae plant Siraitia grosvenorii (Swingle) C. Jeffrey exA.M.Lu et ZYZhang. It tastes sweet and is cool in nature. It has the effects of clearing heat and moistening the lungs, relieving sore throat and opening voice, and lubricating the intestines and relieving constipation.

[0026] Hawthorn, a Chinese medicine, is the dried mature fruit of the plant Crataegus pin,natiida Bge.var.majorN.E.Br. or Crataegus pin.nati fida Bge. of the Rosaceae family. It tastes sour and sweet, is slightly warm in nature, helps digestion and invigorates the stomach, and has the effects of promoting qi and dispersing blood stasis, clearing turbidity and reducing fat.

[0027] Yam, a Chinese medicine name, is the dried rhizome of the Dioscorea plant. It tastes sweet, is neutral in nature, and has the effects of strengthening the spleen, nourishing the lungs, strengthening the kidneys, and improving the essence.

[0028] Goji berry, a Chinese medicine name, is the mature fruit of Lycium chinense Miller or Qinghai wolfberry, a plant of the Solanaceae family. It tastes sweet and is neutral in nature. It has the effects of nourishing the kidneys, moistening the lungs, tonifying the liver, and improving eyesight.

[0029] Eucommia ulmoides, a Chinese medicinal name, is the bark of Eucommia ulmoides Oliv. It is sweet and slightly spicy, warm in nature, and has the effects of nourishing the liver and kidneys, strengthening the tendons and bones, and calming the fetus.

[0030] Codonopsis pilosula, Smilax glabra, Water lily, and Hibiscus mutabilis leaves have significant effects on adjusting the body's metabolic function, promoting uric acid excretion, and improving physical fitness, and are collectively known as the main medicines; Corn silk, dandelion, and Momordica grosvenori have diuretic, heat-clearing and detoxifying effects, which help to excrete excess uric acid in the body and improve damp-heat conditions, thus complementing the main medicine and enhancing the therapeutic effect, and are collectively known as the minister medicines; Hawthorn and yam help digestion, strengthen the stomach, strengthen the spleen and strengthen the kidneys, help coordinate the effects of other medicines, balance the properties of the medicines in combination, and thus enhance the overall efficacy, and are collectively known as the adjuvant medicines; Lycium barbarum and Eucommia ulmoides help nourish the liver and kidneys, regulate qi and blood, promote metabolic balance in the body, synergize with other medicines to enhance the efficacy, and are collectively known as the guiding medicines.

[0031] Compared with the prior art, the present invention has the following beneficial effects:

[0032] (1) The present invention provides a tea substitute for lowering uric acid and assisting in the treatment of gout. The black tea base is compounded with a variety of Chinese herbal medicines and Sargassum polysaccharides for consumption, which has a good uric acid lowering effect and can be used to assist in the prevention and treatment of gout. The tea polyphenols in black tea, the active ingredients in the Chinese herbal medicines and Sargassum polysaccharides can be used in combination to exert a synergistic effect in lowering uric acid, inhibiting inflammation, etc., and improve the therapeutic effect. Among them, a large number of active ingredients with antioxidant and anti-inflammatory effects help to reduce inflammatory reactions and relieve joint pain and swelling caused by gout.

[0033] (2) The present invention provides a tea substitute for lowering uric acid and assisting in the treatment of gout, wherein the Chinese medicinal ingredients are reasonably combined according to the theory of monarch, minister, assistant and envoy, and the effect of lowering uric acid content is remarkable. In addition, Sargassum polysaccharide itself has a certain viscosity and stability, which helps to maintain the physical properties and texture of the product. Sargassum polysaccharide is rich in antioxidants, which can help protect the active ingredients in other formulas, such as tea polyphenols in black tea and active ingredients in Chinese herbal medicines, to prevent them from being damaged by oxidation and losing their activity.

[0034] (3) The present invention provides a tea substitute for lowering uric acid and assisting in the treatment of gout. The raw materials used are medicinal and edible raw materials and commonly used Chinese herbal medicines. The toxicity and side effects are low and the product can be taken for a long time. The product can be made into tea substitute powder and is easy to take. DETAILED DESCRIPTION

[0035] In order to better understand the technical content of the present invention, specific embodiments are provided below to further illustrate the present invention.

[0036] Unless otherwise specified, the experimental methods used in the embodiments of the present invention are all conventional methods.

[0037] Unless otherwise specified, the materials, reagents, etc. used in the embodiments of the present invention can be obtained from commercial sources.

[0038] Example 1

[0039] A tea substitute for lowering uric acid and assisting in the treatment of gout, comprising, by weight: 55 parts of black tea, 12 parts of codonopsis pilosula, 12 parts of smilax glabra, 12 parts of water lily, 12 parts of hibiscus leaves, 8 parts of corn silk, 8 parts of dandelion, 8 parts of momordica grosvenori, 5 parts of hawthorn, 5 parts of yam, 3 parts of wolfberry, 3 parts of eucommia bark, and 2 parts of sargassum polysaccharide.

[0040] The method for preparing the tea substitute for reducing uric acid and assisting in the treatment of gout comprises the following steps:

[0041] S1, decoction: take the required black tea and Chinese medicinal materials by weight, add 8 times the weight of water and decoct twice, each time for 1-2 hours, combine the decoction, filter, concentrate to a relative density of 1.05 at 55°C, and cool;

[0042] S2, alcohol extraction: add 2 times the volume of anhydrous ethanol to the concentrated solution cooled in step S1, filter, and concentrate at 50°C to a relative density of 1.15;

[0043] S3, add Sargassum polysaccharide to the filtrate of S2, mix well, spray dry, and ultrafine grind into fine powder at a speed of 2000r / min for 1h, and the particle size of the fine powder is 10-20μm;

[0044] S4. Vacuum drying to remove residual solvent, vacuum drying temperature is 45°C, pressure is -0.05MPa, drying for 2h, the moisture content of the fine powder after drying is 1.9%, ultraviolet disinfection is carried out, and the powder is packaged into bags.

[0045] Example 2

[0046] A tea substitute for lowering uric acid and assisting in the treatment of gout, comprising, by weight: 75 parts of black tea, 15 parts of codonopsis pilosula, 15 parts of smilax glabra, 15 parts of water lily, 15 parts of hibiscus leaves, 10 parts of corn silk, 10 parts of dandelion, 10 parts of momordica grosvenori, 8 parts of hawthorn, 8 parts of yam, 5 parts of wolfberry, 5 parts of eucommia bark, and 3 parts of sargassum polysaccharide.

[0047] The method for preparing the tea substitute for reducing uric acid and assisting in the treatment of gout comprises the following steps:

[0048] S1, decoction: take the required black tea and Chinese medicinal materials by weight, add 8 times the weight of water and decoct twice, each time for 1-2 hours, combine the decoction, filter, concentrate to a relative density of 1.1 at 55°C, and cool;

[0049] S2, alcohol extraction: add 2 times the volume of anhydrous ethanol to the concentrated solution cooled in step S1, filter, and concentrate at 50°C to a relative density of 1.2;

[0050] S3, add Sargassum polysaccharide to the filtrate of S2, mix well, spray dry, and ultrafine grind into fine powder at a speed of 2500r / min for 2h, and the particle size of the fine powder is 10-20μm;

[0051] S4. Vacuum drying is performed to remove the residual solvent. The vacuum drying temperature is 50°C and the pressure is -0.05MPa. The drying time is 3 hours. The moisture content of the fine powder after drying is 1.8%. The powder is sterilized with ultraviolet light and packaged into bags.

[0052] Example 3

[0053] A tea substitute for lowering uric acid and assisting in the treatment of gout, comprising, by weight: 90 parts of black tea, 18 parts of codonopsis pilosula, 18 parts of smilax glabra, 18 parts of water lily, 18 parts of hibiscus leaves, 12 parts of corn silk, 12 parts of dandelion, 12 parts of monk fruit, 10 parts of hawthorn, 10 parts of yam, 8 parts of wolfberry, 8 parts of eucommia bark, and 5 parts of sargassum polysaccharide.

[0054] The method for preparing the tea substitute for reducing uric acid and assisting in the treatment of gout comprises the following steps:

[0055] S1, decoction: take the required black tea and Chinese medicinal materials by weight, add 8 times the weight of water and decoct twice, each time for 1-2 hours, combine the decoction, filter, concentrate to a relative density of 1.1 at 55°C, and cool;

[0056] S2, alcohol extraction: add 2 times the volume of anhydrous ethanol to the concentrated solution cooled in step S1, filter, and concentrate at 50°C to a relative density of 1.2;

[0057] S3, add Sargassum polysaccharide to the filtrate of S2, mix well, spray dry, and ultrafine grind into fine powder at a speed of 3000r / min for 2h, and the particle size of the fine powder is 10-20μm;

[0058] S4. Vacuum drying to remove residual solvent, vacuum drying temperature is 55°C, pressure is -0.05MPa, drying is for 3h, the moisture content of the fine powder after drying is 1.8%, ultraviolet disinfection is carried out, and the powder is packaged into bags.

[0059] Comparative Example 1

[0060] This example provides a tea substitute for lowering uric acid and assisting in the treatment of gout. Compared with Example 2, the difference is that this example does not contain water flos floridis, and the amount of water flos floridis missing is distributed to the corresponding components according to the proportions of the other three main medicinal substances, codonopsis pilosula, smilax glabra, and hibiscus mutabilis leaves in Example 2. That is, a tea substitute for lowering uric acid and assisting in the treatment of gout includes, by weight: 75 parts of black tea, 20 parts of codonopsis pilosula, 20 parts of smilax glabra, 20 parts of hibiscus mutabilis leaves, 10 parts of corn silk, 10 parts of dandelion, 10 parts of monk fruit, 8 parts of hawthorn, 8 parts of yam, 5 parts of wolfberry, 5 parts of eucommia ulmoides, and 3 parts of sargassum polysaccharide.

[0061] The preparation method of the tea substitute for lowering uric acid and assisting in the treatment of gout is basically the same as that of Example 2.

[0062] Comparative Example 2

[0063] This example provides a tea substitute for lowering uric acid and assisting in the treatment of gout. Compared with Example 2, the difference is that this example does not contain hibiscus leaves, and the amount of hibiscus leaves missing is distributed to the corresponding components according to the proportions of the other three main medicinal substances, codonopsis, smilax glabra, and water flos floridula in Example 2. That is, a tea substitute for lowering uric acid and assisting in the treatment of gout includes, by weight: 75 parts of black tea, 20 parts of codonopsis, 20 parts of smilax glabra, 20 parts of water flos floridula, 10 parts of corn silk, 10 parts of dandelion, 10 parts of monk fruit, 8 parts of hawthorn, 8 parts of yam, 5 parts of wolfberry, 5 parts of eucommia, and 3 parts of sargassum polysaccharide.

[0064] The preparation method of the tea substitute for lowering uric acid and assisting in the treatment of gout is basically the same as that of Example 2.

[0065] Comparative Example 3

[0066] This example provides a tea substitute for lowering uric acid and assisting in the treatment of gout. Compared with Example 2, the difference is that this example does not contain Sargassum polysaccharide.

[0067] The preparation method of the tea substitute for lowering uric acid and assisting in the treatment of gout is basically the same as that of Example 2.

[0068] Comparative Example 4

[0069] This example provides a tea substitute for lowering uric acid and assisting in the treatment of gout. Compared with Example 2, the difference is that in this example, Sargassum polysaccharide is replaced with fucoidan.

[0070] The preparation method of the tea substitute for lowering uric acid and assisting in the treatment of gout is basically the same as that of Example 2.

[0071] Test Example 1 Detection of uric acid lowering effect

[0072] Kunming mice were selected, with a body weight of 18-22g, 90 mice, and randomly divided into 9 groups, 10 mice in each group, half male and half female, respectively, a blank control group, a model group, and an embodiment group. Under the condition of ensuring normal diet and drinking water, the model group and the embodiment group were gavaged with 250mg / kg of potassium oxonate / sodium carboxymethyl cellulose suspension, and the blank group was gavaged with an equal volume of 0.5% sodium carboxymethyl cellulose, and the gavage was continued for 7 days to establish a mouse hyperuricemia animal model. After the potassium oxonate suspension was gavaged for 1h on the same day, the mice in each experimental group were gavaged with a tea drink for reducing uric acid and assisting in the treatment of gout prepared by Examples 1-3 and Comparative Examples 1-4, and the dosage was 300mg / kg / d, and the blank control group and the model group were gavaged with distilled water. The mice were weighed daily, and the gavage volume was adjusted according to the body weight. The gavage was continued for 7 consecutive days. On the 14th day, after gavage administration in each group, they were fasted for 12 hours so that the test could be carried out after the gavage. After the fasting, blood was collected from the orbital vein of each group of mice. After the blood coagulated for 30 minutes at room temperature, it was centrifuged at 4°C and 3000 rpm for 10 minutes to obtain serum, and the blood uric acid content was measured. The test results are shown in Table 1:

[0073] Table 1

[0074] Group Serum UA value (μmol / L) Blank Group 51.5±0.02 Model Group 95.2±0.05 Example 1 52.8±0.07 Example 2 50.2±0.03 Example 3 48.6±0.05 Comparative Example 1 68.2±1.2 Comparative Example 2 64.3±0.08 Comparative Example 3 60.9±0.05 Comparative Example 4 55.2±0.02

[0075] As shown in Table 1, the blood uric acid value of mice in the model group mediated by potassium oxonate increased significantly. The tea substitute for reducing uric acid and assisting the treatment of gout obtained in Examples 1-3 provided by the present invention significantly reduced the serum uric acid index of hyperuricemia mice mediated by potassium oxonate after 7 days of intragastric administration, and no significant difference was shown compared with the blank group, indicating that the uric acid-lowering effect of tea substitute is significant and mild. Comparative Examples 1-2 respectively omitted the water group flower and Hibiscus mutabilis leaves in the monarch medicine, and their uric acid-lowering effect decreased to a certain extent, and the synergistic effect between the components was weakened. The results of Comparative Examples 3-4 show that seaweed polysaccharides have an auxiliary effect on lowering uric acid, and different seaweed polysaccharides have different effects on the stability and efficacy of black tea and Chinese medicine effective ingredients.

[0076] Test Example 2: Detection of the effect on gouty arthritis model rats

[0077] SPF grade SD male rats, 90 rats with a body weight of 250-280g, were selected and randomly divided into 9 groups, 10 rats in each group, namely, blank control group, model group, and embodiment group 7 groups. Under the condition of ensuring normal diet and drinking water, the model control group and the blank control group were gavaged with normal saline, and the experimental group was gavaged with a tea substitute for reducing uric acid and assisting in the treatment of gout prepared by Examples 1-3 and Comparative Examples 1-4, respectively. The dosage of the medicine was 300mg / kg / d, and the medicine was administered once a day for 7 consecutive days. 2h before administration on the sixth day, except for the blank group rats, the remaining groups of rats were injected with 100μL sodium urate suspension into the right hind leg ankle joint articular cavity, and the blank group rats were injected with an equal volume of normal saline. 2h hours after the last day of gavage, the volume of the toes to the ankle joint of each group of rats was measured by a toe volume meter for calculating the degree of swelling of the rat ankle joint. Toe to ankle swelling (ml) = toe to ankle joint volume after the experiment (ml) - toe to ankle joint volume (ml) before the experiment. The mice in each group were decapitated and killed, and the ankle joint tissues of the mice were quickly taken, the foot skin of the mice was removed, the ankle joint tissues were homogenized, the supernatant liquid was taken, and it was allowed to stand for 30 minutes, centrifuged at 3000rpm for 5 minutes, the supernatant was centrifuged repeatedly, and the supernatant was collected and stored in a refrigerator at -20℃ for testing, which was used to detect the content of inflammatory response-related cytokines IL-1β and IL-10 in rat serum. The test results are shown in Table 2.

[0078] Table 2 Ankle joint swelling rate and TNF-α and IL-1β test results

[0079] Group Joint swelling (mL) TNF-α(pg / mL) IL-1β (pg / mL) Blank Group 0.08±0.08 220.61±18.62 152.43±18.62 Model Group 0.42±0.12 416.46±17.56 254.24±16.32 Example 1 0.14±0.16 234.33±20.12 167.32±23.14 Example 2 0.12±0.10 231.09±19.01 163.08±17.35 Example 3 0.12±0.22 230.73±18.92 163.32±22.12 Comparative Example 1 0.24±0.09 291.36±17.42 191.06±19.68 Comparative Example 2 0.22±0.14 283.84±20.39 186.02±13.48 Comparative Example 3 0.20±0.18 268.43±21.06 181.29±20.18 Comparative Example 4 0.17±0.07 249.58±20.86 176.33±17.46

[0080] As can be seen from Table 2, compared with the blank control group, the volume of the hind toes to the ankle joints of the model group rats injected with sodium urate alone increased significantly, and the degree of swelling was high, indicating that the sodium urate injection caused severe swelling of the rat joints, and gouty arthritis was successfully modeled. The rats in Example 1-3 groups were gavaged with a tea substitute for lowering uric acid and assisting in the treatment of gout prepared in Example 1-3, which effectively inhibited the swelling of the rat joints caused by sodium urate injection. Compared with the control group, the TNF-α and IL-1β contents in the ankle joint peripheral tissues of the model group rats with gouty arthritis were significantly increased; compared with the model group, the TNF-α and IL-1β contents in the ankle joint peripheral tissues of the rats with gouty arthritis in Example 1-3 groups were significantly reduced, thereby alleviating joint inflammation.

[0081] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A tea substitute, characterized in that: The raw materials are: 55-90 parts of black tea, 12-18 parts of Codonopsis pilosula, 12-18 parts of Smilax glabra, 12-18 parts of Water lily, 12-18 parts of Hibiscus mutabilis leaves, 8-12 parts of Corn silk, 8-12 parts of Dandelion, 8-12 parts of Momordica grosvenori, 5-10 parts of Hawthorn, 5-10 parts of Chinese yam, 3-8 parts of Lycium barbarum, 3-8 parts of Eucommia ulmoides, 2-5 parts of Sargassum polysaccharide; The preparation method of the tea substitute comprises the following steps: S1. Decoction: Take the required black tea and Chinese medicinal materials by weight, add water to decoct, filter, concentrate and cool; S2, alcohol extraction: add ethanol to the concentrated solution cooled in step S1, filter and concentrate; The amount of ethanol used is 3-5 times the volume of the concentrated liquid after cooling; the filtrate after filtering is concentrated to a relative density of 1.15-1.2; S3, adding Sargassum polysaccharide to the filtrate of S2, mixing evenly, spray drying, and ultrafine grinding into fine powder; S4. Vacuum drying to remove solvent residues, ultraviolet disinfection, and packaging into bags.

2. A tea substitute according to claim 1, characterized in that: The raw materials for the tea substitute are: 75 parts of black tea, 15 parts of Codonopsis pilosula, 15 parts of Smilax glabra, 15 parts of Water lily, 15 parts of Hibiscus mutabilis leaves, 10 parts of Corn silk, 10 parts of Dandelion, 10 parts of Momordica grosvenori, 8 parts of Hawthorn, 8 parts of Chinese yam, 5 parts of Lycium barbarum, 5 parts of Eucommia ulmoides, and 3 parts of Sargassum polysaccharide.

3. A tea substitute according to claim 1, characterized in that: After filtration in S1, the filtrate is concentrated to a relative density of 1.05-1.

1.

4. A tea substitute according to claim 1, characterized in that: The vacuum drying temperature is 45-55° C., the pressure is -0.05 MPa, and the drying time is 2-3 hours; the moisture content of the fine powder after drying does not exceed 2%.

5. The tea substitute according to claim 1, characterized in that: The ultrafine grinding speed is 2000-3000r / min, the time is 1-2h, and the fine powder particle size is 10-20μm.