Respiratory parameter measurement system and method

Abstract

The application discloses a kind of respiratory parameter measurement system and method, the system, comprising: interactive module, excitation generation module, interface module, detection module and central processing module;Interactive module is used to the target working parameter based on the parameter setting interface of display is acquired and is transmitted to central processing module;Central processing module is used to in the case where target working parameter includes first working parameter, control excitation generation module generates detection sound wave signal, and detection control signal generated according to first working parameter is sent to detection module;Interface module is used to load detection sound wave signal to measured sample, and load return sound wave to airway pipeline;Detection module is used to receive detection control signal, and the return sound wave of airway pipeline is detected to obtain sound wave detection signal;Central processing module is also used to determine the target airway parameter corresponding to measured sample according to received sound wave detection signal, and the measurement precision of target airway parameter can be improved.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, in particular to a respiratory parameter measurement system and method. BACKGROUND

[0002] Pulmonary function test is an important means for diagnosing respiratory system obstruction, asthma and other diseases. Compared with common pulmonary function tests such as spirometer, peak flow meter and the like, respiratory oscillation measurement technology requires the patient to actively cooperate with the test to perform exhalation, inhalation or breath holding operation, and thus is not suitable for severe patients or the elderly. The oscillation measurement technology does not require the cooperation of the subject, and thus has important application value in the clinic.

[0003] At present, the oscillation method pulmonary function detection is a new type of pulmonary function detection technology based on forced oscillation technology for measuring human respiratory impedance. It does not require the active cooperation of the subject, and can distinguish the resistance changes of inhalation and exhalation phases, identify respiratory system lesions caused by smoking in early stage, and has been recommended by the European Respiratory Society as a recommended pulmonary function detection method. The technical principle is to regard the human respiratory system as an electric circuit system composed of resistance, inductance and capacitance, generate mechanical waves of different frequencies by an external generator, monitor the flow rate and pressure signals of the subject during normal breathing, calculate the human respiratory impedance by referring to the impedance and voltage current relationship in the circuit. And combined with the respiratory impedance model analysis, the characteristic indexes under different frequency excitation signals are extracted. However, the frequency information obtained based on the existing forced oscillation technology is limited, which limits the diagnostic accuracy. SUMMARY

[0004] The present application provides a respiratory parameter measurement system and method to solve the problem of low respiratory parameter measurement accuracy, and improves the respiratory parameter measurement accuracy.

[0005] According to one aspect of the present application, a respiratory parameter measurement system (100) is provided, comprising: an interaction module (110), an excitation generation module (120), an interface module (130), a detection module (140) and a central processing module (150); the excitation generation module (120) and the interface module (130) are connected through an airway pipeline (160), the interaction module (110) and the interface module (130) are respectively in communication connection with the central processing module (150), and the detection module (140) is in communication connection with the central processing module (150); wherein,

[0006] The interaction module (110) is configured to display a parameter setting interface, obtain target working parameters set based on the parameter setting interface, and transmit the target working parameters to the central processing module (150);

[0007] a central processing module (150) configured to, in a case where the target working parameter comprises a first working parameter, control the excitation generation module (120) to generate a detection acoustic wave signal according to the first working parameter, and generate a detection control signal according to the first working parameter, and send the detection control signal to the detection module (140); wherein the first working parameter comprises an initial frequency, a linear modulation index, and a transmission pulse period;

[0008] an interface module (130) configured to acquire the detection acoustic wave signal generated by the excitation generation module (120), and load the detection acoustic wave signal to the sample to be measured through an airway pipeline (160), and collect a return acoustic wave corresponding to the detection acoustic wave signal, and load the return acoustic wave to the airway pipeline (160);

[0009] a detection module (140) configured to receive the detection control signal, and detect the return acoustic wave of the airway pipeline (160) according to the detection control signal, to obtain an acoustic wave detection signal;

[0010] the central processing module (150) is further configured to receive the acoustic wave detection signal, and determine a target airway parameter corresponding to the sample to be measured according to the acoustic wave detection signal.

[0011] According to another aspect of the present application, a respiratory parameter measurement method is provided, comprising:

[0012] displaying a parameter setting interface based on the interaction module, acquiring a target working parameter set based on the parameter setting interface, and transmitting the target working parameter to the central processing module;

[0013] controlling the excitation generation module to generate a detection acoustic wave signal according to the first working parameter, and generating a detection control signal according to the first working parameter, and sending the detection control signal to the detection module based on the central processing module in a case where the target working parameter comprises a first working parameter; wherein the first working parameter comprises an initial frequency, a linear modulation index, and a transmission pulse period;

[0014] acquiring the detection acoustic wave signal generated by the excitation generation module, and loading the detection acoustic wave signal to the sample to be measured through an airway pipeline based on the interface module, and collecting a return acoustic wave corresponding to the detection acoustic wave signal, and loading the return acoustic wave to the airway pipeline;

[0015] receiving the detection control signal, and detecting the return acoustic wave of the airway pipeline according to the detection control signal, to obtain an acoustic wave detection signal based on the detection module;

[0016] receiving the acoustic wave detection signal, and determining a target airway parameter corresponding to the sample to be measured according to the acoustic wave detection signal based on the central processing module;

[0017] The excitation generation module and the interface module are connected through an airway pipeline, the interaction module and the interface module are respectively in communication connection with the central processing module, and the detection module is in communication connection with the central processing module.

[0018] The technical scheme of the embodiment of the present application provides a respiratory parameter measurement system (100), which comprises an interaction module (110), an excitation generation module (120), an interface module (130), a detection module (140) and a central processing module (150); the excitation generation module (120) and the interface module (130) are connected through an airway pipeline (160), the interaction module (110) and the interface module (130) are respectively in communication connection with the central processing module (150), and the detection module (140) is in communication connection with the central processing module (150); wherein the interaction module (110) is used for displaying a parameter setting interface, acquiring target working parameters set based on the parameter setting interface, and transmitting the target working parameters to the central processing module (150); the central processing module (150) is used for, in the case that the target working parameters comprise first working parameters, controlling the excitation generation module (120) to generate a detection sound wave signal according to the first working parameters, and generating a detection control signal according to the first working parameters and sending the detection control signal to the detection module (140); wherein the first working parameters comprise an initial frequency, a linear modulation index and a transmission pulse period; the interface module (130) is used for acquiring the detection sound wave signal generated by the excitation generation module (120), loading the detection sound wave signal to a sample to be measured through the airway pipeline (160), collecting a return sound wave corresponding to the detection sound wave signal, and loading the return sound wave to the airway pipeline (160); the detection module (140) is used for receiving the detection control signal and detecting the return sound wave of the airway pipeline (160) according to the detection control signal to obtain a sound wave detection signal; and the central processing module (150) is further used for receiving the sound wave detection signal and determining target airway parameters corresponding to the sample to be measured according to the sound wave detection signal. The excitation generation module (120) can encode the sound wave excitation for detecting the respiratory parameter based on the first working parameters, so that the detection module (140) can detect the sound wave detection signal corresponding to the detection sound wave signal of multiple frequencies, and compared with the sound wave detection signal corresponding to the detection sound wave signal of a single frequency, more frequency information can be acquired based on the sound wave detection signal corresponding to the detection sound wave signal of multiple frequencies, which is helpful to improve the respiratory parameter measurement precision.

[0019] It should be understood that the content described in this part is not intended to identify key or important features of the embodiments of the present application, nor is it used to limit the scope of the present application. Other features of the present application will become apparent through the following description. BRIEF DESCRIPTION OF DRAWINGS

[0020] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following will briefly introduce the drawings needed in the embodiment description. Obviously, the drawings in the following description are only some embodiments of the present application, and for those skilled in the art, other drawings can be obtained without creative labor based on these drawings.

[0021] Figure 1 is a structural schematic diagram of a respiratory parameter measurement system provided by an embodiment of the present application;

[0022] Figure 2 is a flow chart of a respiratory parameter measurement method provided by an embodiment of the present application. DETAILED DESCRIPTION

[0023] In order to make the person skilled in the art better understand the present application, the following will combine the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are only some embodiments of the present application, not all. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor should be within the scope of the present application.

[0024] It should be noted that the terms "first", "second", etc. in the specification and claims of the present application and the above-mentioned drawings are used to distinguish similar objects, and do not necessarily describe a specific order or sequence. It should be understood that the data thus used can be interchanged under appropriate circumstances, so that the embodiments of the present application described herein can be implemented in an order other than those illustrated or described herein. In addition, the terms "include" and "have" and any variations thereof are intended to cover non-exclusive inclusion, for example, a process, method, system, product or device including a series of steps or units does not necessarily limit to those steps or units clearly listed, but can include other steps or units not clearly listed or inherent to these processes, methods, products or devices.

[0025] Embodiment one

[0026] Figure 1 is a structural schematic diagram of a respiratory parameter measurement system provided by an embodiment of the present application. The present embodiment can be applicable to the case of detecting the respiratory parameter of the measured sample. The respiratory parameter measurement system can be realized in the form of hardware and / or software. Optionally, it is realized by an electronic device, which can be a mobile terminal, a PC terminal or a server, etc.

[0027] In the embodiment, the sample to be measured is a sample for detecting a respiratory parameter, which can be a human body or other animal body containing a respiratory system, and the embodiment does not limit this. The respiratory parameter is a parameter for characterizing the lung function of the sample to be measured, and the respiratory parameter includes but is not limited to respiratory impedance, respiratory resistance, resonant frequency and respiratory reactance. By regarding the respiratory system of the sample to be measured as a circuit system composed of resistance, inductance and capacitance, and by generating mechanical waves of different frequencies by an external generator, the flow and pressure signals of normal breathing of the sample to be measured are detected, and the respiratory parameter of the sample to be measured is calculated by referring to the impedance-voltage-current relationship in the circuit.

[0028] As shown in Figure 1 The respiratory parameter measurement system 100 can specifically include an interaction module 110, an excitation generation module 120, an interface module 130, a detection module 140 and a central processing module 150. The excitation generation module 120 and the interface module 130 are connected through an airway pipeline 160, the interaction module 110 and the interface module 130 are respectively connected in communication with the central processing module 150, and the detection module 140 is connected in communication with the central processing module 150.

[0029] The interaction module 110 is configured to display a parameter setting interface, obtain target working parameters set based on the parameter setting interface, and transmit the target working parameters to the central processing module 150.

[0030] In the embodiment, the interaction module 110 is a module for interacting with a user in the respiratory parameter measurement system 100. The parameter setting interface is an interactive interface for setting target working parameters. The interaction module 110 realizes the interaction between the user and the respiratory parameter measurement system 100 by visualizing the parameter setting interface. The parameter setting interface includes but is not limited to a graphical user interface, a command line interface and other types of interactive interfaces.

[0031] Specifically, the parameter setting interface responds to the input operation or selection operation of the user, sets or adjusts the target working parameter based on the information input or selected by the user, converts the set target working parameter into a data format recognizable by the respiratory parameter measurement system 100, and transmits the target working parameter after data format conversion to the central processing module 150 in a wired or wireless manner. Wherein, the target working parameter is a parameter used to guide the working of the respiratory parameter measurement system 100. Exemplarily, the working parameter includes but is not limited to a working mode parameter and an attribute configuration parameter, wherein the working mode parameter is a parameter used to guide the working mode of the respiratory parameter measurement system 100, which can control the excitation generation module 120, the interface module 130, the detection module 140 and the central processing module 150 to perform tasks in a specific working mode; the attribute configuration parameter is a parameter used to configure the attribute of the respiratory parameter measurement system 100 (for example, the frequency of the detection sound wave signal generated by the excitation generation module 120). It can be understood that each working mode parameter is associated with multiple attribute configuration parameters, and the same attribute configuration parameter can be associated with one or more working mode parameters.

[0032] In some embodiments, optionally, the interaction module 110 includes an interface setting submodule and a parameter conversion submodule; wherein the interface setting submodule is used to display a parameter setting interface and display parameter setting items in the parameter setting interface; the parameter conversion submodule is used to determine a target working mode based on the setting parameter of the working mode setting item, determine a target working parameter according to the target working mode, and transmit the target working parameter to the central processing module 150.

[0033] Wherein, the parameter setting item includes a working mode setting item.

[0034] In this embodiment, the interface setting submodule and the parameter conversion submodule in the interaction module 110 work cooperatively to provide the target working parameter setting and transmission function. The parameter setting item is one or more data items of the target working parameter that need to be set by the user. It can be understood that the parameter setting item includes but is not limited to a working mode setting item and an attribute setting item. Wherein, the working mode setting item is a parameter setting item used to set the working mode parameter, and the attribute setting item is a parameter setting item used to set the attribute configuration parameter. It can be understood that each working mode setting item is associated with multiple attribute setting items.

[0035] Specifically, the interface setting submodule creates the parameter setting interface by calling a graphical interface library or component, and displays the parameter setting interface, wherein the parameter setting interface includes multiple parameter setting items, and the parameter setting item can be obtained by combining one or more interactive elements such as an input box and a selection box, so as to input or select the setting parameter of the parameter setting item by the user.

[0036] The parameter conversion submodule determines the target working parameter based on the setting parameters of the plurality of parameter setting items by reading the setting parameters of the plurality of parameter setting items. The parameter setting items include a working mode setting item. It should be noted that the working mode setting item corresponds to a plurality of candidate working mode setting parameters, different candidate working mode setting parameters correspond to different working modes, and the setting parameter of the working mode setting item set by the user is any candidate working mode setting parameter. The target working mode is a working mode to be executed by the respiratory parameter measurement system 100, and different target working modes correspond to different candidate working mode setting parameters. The parameter conversion submodule determines the working mode corresponding to the setting parameter of the working mode setting item as the target working mode, and obtains the target working parameter by combining the working mode parameter corresponding to the target working mode and the setting parameter of the other parameter setting items (for example, the attribute setting item) associated with the working mode parameter. The parameter conversion submodule transmits the target working parameter to the central processing module 150 based on the communication connection between the interaction module 110 and the central processing module 150.

[0037] For example, it is assumed that the interface setting submodule sets 3 candidate working mode setting parameters for the working mode setting item, which are the target airway parameter detection working mode, the sputum presence state detection working mode, and the end working mode. The logical identifier of the target airway parameter detection working mode is "1", the logical identifier of the sputum presence state detection working mode is "2", and the logical identifier of the end working mode is "3". In the case where the setting parameter of the working mode setting item read by the parameter conversion submodule is "3", the end working mode corresponding to "3" is determined as the target working mode, and the working mode parameter in the target working parameter is set to the working mode parameter corresponding to the end working mode.

[0038] The technical solution of the embodiment improves the maintainability and expandability of the interaction module 110 by modularizing the interaction module 110 into the interface setting submodule and the parameter conversion submodule, and cooperatively performing the target working parameter and transmission by the interface setting submodule and the parameter conversion submodule.

[0039] The central processing module 150 is configured to, in the case where the target working parameter includes a first working parameter, control the excitation generation module 120 to generate a detection sound wave signal according to the first working parameter, and generate a detection control signal according to the first working parameter and send the detection control signal to the detection module 140.

[0040] The first working parameter includes an initial frequency, a linear modulation index, and a transmission pulse period.

[0041] In the embodiment, the excitation generation module 120 is a module for generating a target mechanical wave signal, wherein the target mechanical wave signal is a signal with attributes set based on the target working parameters, which can be a fixed frequency signal or a variable frequency signal, and the embodiment does not limit this. The target mechanical wave signal includes a detection control signal, wherein the detection sound wave signal is a signal with attributes set based on the first working parameter in the target working parameters, which is used to impact the respiratory system of the measured sample, so that the respiratory system of the measured sample responds to the feedback containing airway characteristic information to the received detection sound wave signal.

[0042] Specifically, the central processing module 150 identifies the first working parameter in the received target working parameters. In the case of identifying the first working parameter, it is determined that the target working parameters include the first working parameter, and it is considered that the central processing module 150 has priority in controlling the excitation generation module 120 to generate the detection sound wave signal corresponding to the first working parameter in the generation control of one or more target mechanical wave signals of the excitation generation module 120. Therefore, the central processing module 150 sends the first working parameter to the excitation generation module 120, so that the excitation generation module 120 generates the detection sound wave signal in response to the received first working parameter. In some embodiments, the central processing module 150 generates a first working parameter excitation control signal including the first working parameter, and communicates the excitation control signal to the excitation generation module 120; the excitation generation module 120 obtains the first working parameter by analyzing the received excitation control signal, and generates the detection sound wave signal based on the first working parameter.

[0043] It should be noted that the excitation generation module 120 is composed of a function generator, a power amplifier and an oscillation source. The function generator is used to generate the detection sound wave signal, and the function generator stores one or more detection sound wave signal generation functions, and each detection sound wave signal generation function has one or more user adjustable parameters. The power amplifier is used to amplify the detection sound wave signal generated by the function generator, and transmit the amplified detection sound wave signal to the oscillation source to excite the oscillation source to vibrate and move the gas to generate oscillation sound waves, for example, the oscillation source is a loudspeaker.

[0044] The excitation generation module 120 determines the detection sound wave signal generation function called by the function generator based on the initial frequency, the linear modulation index and the transmission pulse period in the first working parameter. It should be noted that the linear modulation index and the transmission pulse period in the initial frequency, the linear modulation index and the transmission pulse period received by the excitation generation module 120 can be null. For example, it is assumed that the function generator stores a variable frequency detection sound wave signal generation function and a fixed frequency detection sound wave signal generation function. In the case that the excitation generation module 120 identifies that the linear modulation index and the transmission pulse period are null, it is considered that the frequency of the detection sound wave signal is fixed, and the initial frequency is substituted into the fixed frequency detection sound wave signal generation function to generate a fixed frequency detection sound wave signal. In the case that the excitation generation module 120 identifies that the linear modulation index and the transmission pulse period are not null, it is considered that the frequency of the detection sound wave signal is not fixed, and the initial frequency, the linear modulation index and the transmission pulse period are substituted into the variable frequency detection sound wave signal generation function to generate a variable frequency detection sound wave signal.

[0045] In some embodiments, the first working parameter further includes a signal generation function parameter, wherein the signal generation function parameter represents the detection sound wave signal generation function called by the function generator. For example, it is assumed that the signal generation function parameter "1" represents the variable frequency detection sound wave signal generation function. If the excitation generation module 120 identifies that the signal generation function parameter in the first working parameter is "1", the variable frequency detection sound wave signal generation function called by the function generator generates a variable frequency detection sound wave signal based on the initial frequency, the linear modulation index, the transmission pulse period and the variable frequency detection sound wave signal generation function.

[0046] The detection control signal is a signal for controlling the detection module 140 to perform detection. The central processing module 150 generates the detection control signal in response to the identified first working parameter, and communicates the detection control signal to the detection module 140. It should be noted that the central processing module 150 can simultaneously transmit the first working parameter (or the excitation control signal) to the excitation generation module 120 and transmit the detection control signal to the detection module 140, or first transmit the first working parameter (or the excitation control signal) to the excitation generation module 120 and then transmit the detection control signal to the detection module 140, which is not limited in the present embodiment.

[0047] The interface module 130 is configured to obtain the detection sound wave signal generated by the excitation generation module 120, load the detection sound wave signal to the sample to be measured through the airway pipeline 160, and collect the return sound wave corresponding to the detection sound wave signal and load the return sound wave to the airway pipeline 160.

[0048] Specifically, the interface module 130 is a test port of the measured sample. The excitation generation module 120 sends the detection acoustic wave signal to the airway pipeline 160, and the interface module 130 receives the detection acoustic wave signal propagating along the airway pipeline 160. The interface module 130 is connected with the oral cavity of the measured sample, and the interface module 130 transmits the received detection acoustic wave signal to the respiratory system of the measured sample. For example, it is assumed that the interface module 130 includes a mask, and the interface module 130 is connected with the oral cavity of the measured sample by wearing the mask on the face of the measured sample. Part of the detection acoustic wave signal will be reflected back to form a return acoustic wave after encountering the respiratory system of the measured sample. The interface module 130 collects the return acoustic wave of the respiratory system of the measured sample in real time, and loads the return acoustic wave to the airway pipeline 160 in real time, so as to realize the propagation of the return acoustic wave along the airway pipeline 160. For example, as shown in FIG. 1, the airway pipeline 160 is an L-shaped pipeline. Figure 1

[0049] It should be noted that the interface module 130 is a key part connecting the excitation generation module 120 and the measured sample. If the interface module 130 leaks, it will affect the transmission effect of the detection acoustic wave signal, and further affect the performance of the respiratory parameter measurement system 100. Optionally, the interface module 130 includes: a gas leakage sensor; wherein the gas leakage sensor is used for detecting the gas leakage of the interface module 130 to obtain a gas leakage signal, and transmitting the gas leakage signal to the central processing module 150; the central processing module 150 is further used for determining whether the gas leakage occurs according to the received gas leakage signal; and in the case that no gas leakage occurs within a preset time length, the detection control signal is sent to the detection module 140.

[0050] In this embodiment, the gas leakage sensor is a sensor for detecting gas leakage, which is composed of a high-sensitivity airflow detection element and can detect the gas flow of the interface module 130 in real time.

[0051] ​Specifically, the air leakage sensor detects the air leakage condition of the interface module 130 in real time, generates an air leakage signal of the current time based on the air leakage condition, and transmits the air leakage signal of the current time to the central processing module 150. The air leakage signal is an electronic signal representing the air leakage condition, usually having a specific format and coding to be accurately recognized by the central processing module 150. For example, when the air leakage condition is air leakage, the air leakage signal is high; when the air leakage condition is no air leakage, the air leakage signal is low. The central processing module 150 compares the received air leakage signal with a preset air leakage condition. When the air leakage signal meets the preset air leakage condition, it is considered that the air leakage signal indicates that the interface module 130 leaks, and it is determined that air leakage occurs. The preset air leakage condition is a condition of the air leakage signal that is preset to determine air leakage. For example, the preset air leakage condition is high. The preset time length is a preset air leakage detection time length. If multiple air leakage signals detected within the preset time length all represent no air leakage, it is considered that the interface module 130 is tightly connected with the measured sample and can obtain accurate respiratory parameters. Then, the central processing module 150 sends a detection control signal to the detection module 140 to control the detection module 140 to perform detection. If at least one air leakage signal detected within the preset time length represents air leakage, it is considered that the interface module 130 is not tightly connected with the measured sample and cannot obtain accurate respiratory parameters. Then, the central processing module 150 takes corresponding measures when air leakage occurs, such as air leakage alarm and control of the excitation generation module 120 to stop generating the detection sound wave signal, to restore the respiratory parameter measurement system 100 to normal operation. For example, the preset time length is 10 seconds.

[0052] The technical scheme of the embodiment can ensure that the interface module 130 does not leak during the sound wave detection process of the detection module 140 by detecting air leakage based on the air leakage sensor and sending a detection control signal to the detection module 140 when no air leakage occurs within a preset time length, thereby ensuring the performance of the respiratory parameter measurement system 100.

[0053] The detection module 140 receives the detection control signal and detects the return sound wave of the airway pipeline 160 according to the detection control signal to obtain a sound wave detection signal.

[0054] In the embodiment, the sound wave detection signal is a signal representing the lung function of the measured sample. It can be understood that the sound wave detection signal includes but is not limited to the amplitude, frequency and phase of the return sound wave.

[0055] Specifically, the detection module 140 detects the return sound wave of the airway pipeline 160 in response to the received detection control signal, and collects sound wave detection signals at a plurality of continuous sampling time points. The detection module 140 communicates the collected sound wave detection signals to the central processing module 150. It can be understood that the detection module 140 is composed of a plurality of sound wave detection sensors and signal processing circuits, for example, the sound wave detection sensors include but are not limited to sound pressure sensors and air flow sensors, and the signal processing circuits include but are not limited to coaxial shielded cables, multi-channel amplifiers and A / D collectors, which can accurately detect the sound wave detection signals.

[0056] The central processing module 150 is also configured to receive the sound wave detection signals and determine the target airway parameter corresponding to the measured sample according to the sound wave detection signals.

[0057] In this embodiment, the target airway parameter is a pre-set respiratory parameter that needs to be determined based on the sound wave detection signal. Exemplarily, the target airway parameter includes but is not limited to respiratory impedance, respiratory resistance, resonant frequency and respiratory reactance.

[0058] Specifically, the central processing module 150 receives the sound wave detection signals transmitted by the detection module 140 in real time, and decodes the sound wave detection signals at each sampling time point to obtain decoded sound wave detection signals. In some embodiments, the central processing module 150 is also configured to pre-process the sound wave detection signals before decoding, wherein the pre-processing includes filtering the sound wave detection signals based on a pre-set filtering algorithm and de-noising the sound wave detection signals based on a pre-set de-noising algorithm, wherein the pre-set filtering algorithm includes but is not limited to mean filtering, median filtering and Gaussian filtering; and the pre-set de-noising algorithm includes but is not limited to wavelet transform and deep learning-based de-noising algorithm. It should be noted that the pre-processing submodule can only perform filtering or de-noising, or can perform filtering and de-noising in sequence, and the filtering can be performed before or after the de-noising, which is not limited in this embodiment. By pre-processing the sound wave detection signals, the quality of the sound wave detection signals can be improved, and the reliability of decoding the sound wave detection signals can be improved. By determining the amplitude and phase of the decoded sound wave detection signals, the airway parameter calculation processing is performed to obtain the target airway parameter corresponding to the measured sample.

[0059] For example, it is assumed that the sound wave detection signal includes a flow signal Q(t) and a pressure signal P(t), wherein the flow signal is a signal collected by the airflow sensor and represents the flow of the returned sound wave in the airway pipeline 160; the pressure signal is a signal collected by the sound pressure sensor and represents the internal air pressure of the airway pipeline 160. By decoding the flow signal Q(t) and the pressure signal P(t) respectively, the decoded flow signal Q'(t) and the decoded pressure signal P'(t) are obtained. The respiratory system resistance (Rrs) and the respiratory reactance (Xrs) are calculated based on the following formulas: Rrs = Z t *cos(Φ t ) and Xrs = Z t *sin(Φ t ), wherein Z t represents the total impedance of the respiratory system at the sampling time point t, wherein |Z t | = |p t | / |q t |, p t represents the flow amplitude of P'(t) at the sampling time point t, q t represents the pressure amplitude of Q'(t) at the sampling time point t, and Φ t represents the phase information at the sampling time point t, wherein Φ t = θ(p t )-θ(q t ), θ(p t ) represents the pressure phase of P'(t) at the sampling time point t, and θ(q t ) represents the flow phase of Q'(t) at the sampling time point t.

[0060] It can be understood that different types of detection sound wave signals have different decoding methods. Optionally, the central processing module 150 is specifically configured to, in the case that the detection sound wave signal is a conjugate sound wave signal, perform convolution complex conjugate calculation processing on the sound wave detection signal and the detection sound wave signal to obtain a target detection signal, and determine a target airway parameter based on the target detection signal.

[0061] In this embodiment, the conjugate sound wave signal is a signal with phase conjugate property, and the conjugate sound wave signal can cancel the specific frequency interference generated by the spontaneous breathing of the measured sample, which is helpful to obtain the multi-frequency response of the respiratory system of the measured sample.

[0062] It should be noted that the excitation generation module 120 generates a detection acoustic signal as a conjugate acoustic signal in the case that the first working parameter includes the initial frequency, the linear modulation index and the transmission pulse period are all not empty, and the detection acoustic signal generation function called by the function generator is the conjugate acoustic signal generation function. For example, the detection acoustic signal is s(t) = cos[2π(f0t + Kt 2 / 2)], f0 represents the initial frequency corresponding to the first working parameter, K represents the linear modulation index corresponding to the first working parameter, and the frequency of the detection acoustic signal is f = f0 + KT, where T represents the transmission pulse period corresponding to the first working parameter. It should be noted that the frequency of the conjugate acoustic signal is between 1 Hz and 30 Hz, for example, f = 15 Hz. It can be understood that, based on the first working parameter including the initial frequency, the linear modulation index and the transmission pulse period, the conjugate acoustic signal is generated, different types and characteristics of the conjugate acoustic signal can be generated by adjusting the initial frequency, the linear modulation index and the transmission pulse period, and the application range of the respiratory parameter measurement system 100 is increased; and the conjugate acoustic signal is a continuous wave, which has less impact on the internal organs of the measured sample than the pulsed excitation acoustic wave, and helps to reduce the discomfort of the measured sample during detection.

[0063] Specifically, the center processing module 150 performs convolution complex conjugate calculation processing on the acoustic detection signal input from the detection module 140 based on the detection acoustic signal generated by the excitation generation module 120, decodes the detection acoustic signal to obtain a target detection signal. For example, assuming that the acoustic detection signal includes a flow signal Q(t) and a pressure signal P(t), the target detection signal includes a decoded flow signal Q'(t) and a decoded pressure signal P'(t), where Q'(t) = Q(t)**s(t) and P'(t) = P(t)**s(t), and ** represents convolution complex conjugate.

[0064] The center processing module 150 obtains the amplitude and phase information of the target detection signal by performing amplitude extraction and phase information extraction on the target detection signal, and performs airway parameter calculation processing based on the amplitude and phase information of the target detection signal to obtain a target airway parameter corresponding to the measured sample.

[0065] For example, assuming that the target detection signal includes a decoded flow signal Q'(t) and a decoded pressure signal P'(t), and the airway parameter includes Rrs and Xrs, the airway parameter determination sub-module substitutes the amplitude |q t and the phase information θ(q t ) of Q'(t) and the amplitude |p t and the phase information θ(p t ) of P'(t) into Rrs = Zt *cos(Φ t ) and Xrs = Z t *sin(Φ t ) to obtain the target airway parameter.

[0066] The technical scheme of the embodiment, the central processing module 150 obtains the target detection signal by performing convolution complex conjugate calculation processing on the sound wave detection signal and the detection sound wave signal, can decode the target detection signal from the sound wave detection signal, and strengthens the target detection signal and suppresses background noise or other interference in the sound wave detection signal, thereby improving the quality and signal-to-noise ratio of the target detection signal, and helping to further improve the respiratory parameter measurement accuracy.

[0067] In some embodiments, optionally, the respiratory parameter measurement system 100 further comprises a display module; the display module is in communication connection with the central processing module 150; wherein the central processing module 150 is further configured to compare the target airway parameter with a preset parameter range, send the target airway parameter to the display module in the case that the target airway parameter meets the preset parameter range, and generate an alarm information and send the alarm information to the display module in the case that the target airway parameter does not meet the preset parameter range; and the display module is configured to receive the target airway parameter and / or the alarm information, and display the target airway parameter and / or the alarm information.

[0068] In the embodiment, the display module includes but is not limited to a liquid crystal display screen and an LED display screen. The display module can be configured on the surface of one or more of the interactive module 110, the excitation generation module 120, the interface module 130, the detection module 140, and the central processing module 150, and the embodiment does not limit this.

[0069] Specifically, the preset parameter range is a range of the airway parameter set in advance, and is used to determine whether the airway parameter is sent to the display module. Exemplarily, the preset parameter range can be a default parameter range, or a preset parameter range set based on the interaction module 110, and the present embodiment does not limit this. It can be understood that the target airway parameter includes a plurality of respiratory parameters, and the preset parameter range includes a preset parameter range corresponding to each respiratory parameter. The central processing module 150 calls the preset parameter range, and determines the preset parameter range corresponding to each respiratory parameter in the target airway parameter based on the preset parameter range. For each respiratory parameter, the value of the respiratory parameter in the target airway parameter is compared with the preset parameter range of the respiratory parameter, and in the case that the value of each respiratory parameter is within the preset parameter range of the respiratory parameter, it is considered that the target airway parameter meets the preset parameter range, and then the central processing module 150 sends the target airway parameter to the display module. The display module responds to the received airway parameter, analyzes the target airway parameter, obtains a plurality of respiratory parameters, and displays the values of the plurality of respiratory parameters.

[0070] Exemplarily, it is assumed that the target airway parameter includes Rrs, Xrs and resonance frequency (Fres), the preset parameter range of Rrs is (0, 1), the preset parameter range of Xrs is (-1, 1), and the preset parameter range of Fres is (0, 25), then if 0 < Rrs < 1, -1 < Xrs < 1, 0 < Fres < 25, the central processing module 150 determines that the target airway parameter meets the preset parameter range, and sends the target airway parameter to the display module.

[0071] The alarm information is information used to remind the user that the target airway parameter is abnormal, and the alarm information includes but is not limited to the values of the plurality of respiratory parameters in the target airway parameter, the degree to which the target airway parameter exceeds the preset parameter range, and the alarm occurrence time. For the plurality of respiratory parameters in the target airway parameter, in the case that the value of any respiratory parameter is outside the preset parameter range of the respiratory parameter, the alarm information is generated based on the target airway parameter and the preset parameter range. In some embodiments, the central processing module 150 can send the alarm information to the interaction module 110, the interaction module 110 can interact with the interaction module 110 through sound and vibration, and the user can confirm the alarm, contact the alarm and perform troubleshooting operation through touch interaction with the interaction module 110; in some embodiments, the central processing module 150 can also send the alarm information to the display module, and the display module presents the alarm information in a target visual manner, so that the user can directly view, wherein the target visual manner includes but is not limited to text and image; in some embodiments, the central processing module 150 can send the alarm information to the interaction module 110 and the display module at the same time, which can ensure that the user receives the alarm information in time.

[0072] The technical solution of the embodiment can avoid transmitting invalid airway parameters, help improve the performance and stability of the respiratory parameter measurement system 100, and reduce the occurrence of errors and abnormal conditions by transmitting the airway parameters to the display module when the airway parameters meet the preset parameter range instead of directly transmitting the airway parameters to the display module after obtaining the airway parameters; the airway parameters can be conveniently read by the user by displaying the airway parameters by the display module. The reliability of the system and the user experience are improved by generating an alarm information and transmitting the alarm information to the display module when the airway parameters do not meet the preset parameter range, which helps to ensure the safe and stable operation of the respiratory parameter measurement system 100.

[0073] Optionally, the central processing module 150 is further configured to control the excitation generation module 120 to stop generating the detection sound wave signal and control the detection module 140 to stop detecting the return sound wave of the airway pipeline 160 when it is detected that the preset stop detection condition is reached.

[0074] In the embodiment, the stop detection condition is a preset condition for determining to stop detecting the target airway parameter. For example, the stop detection condition includes one or more of target airway parameter generation, alarm information generation, determination of air leakage, and end of work mode represented by the target working parameter.

[0075] Specifically, during the detection of the target airway parameter by the respiratory parameter measurement system 100, the central processing module 150 continuously detects the current detection state. When it is detected that the current detection state meets the preset stop detection condition, it is considered that the detection of the target airway parameter is completed, a stop detection control signal is generated, and the stop detection control signal is transmitted to the excitation generation module 120 and the detection module 140. The detection state is the progress state of the detection of the target airway parameter by the respiratory parameter measurement system 100, and includes but is not limited to signal (e.g., detection control signal and sound wave detection signal) generation condition and parameter (e.g., target airway parameter) generation condition, wherein the generation condition includes generated and not generated. The excitation generation module 120 stops outputting the conjugate sound wave signal in response to the stop detection control signal; the detection module 140 stops detecting the return sound wave of the airway pipeline 160 in response to the stop detection control signal. For example, it is assumed that the stop detection condition includes target airway parameter generation, and the central processing module 150 detects that the target airway parameter generation condition in the current detection state is generated, which is considered to reach the preset stop detection condition.

[0076] The technical solution of the embodiment can ensure that the detection of the target airway parameter is stopped in time when the preset stop detection condition is reached, thereby avoiding unnecessary resource waste and false detection, and helping to improve the detection efficiency and accuracy of the respiratory parameter measurement system 100, and providing reliable and efficient target airway parameter detection services for users.

[0077] It can be understood that after the control excitation module and the detection module 140 stop working, the respiratory parameter measurement system 100 can save the currently set working parameter and the airway parameter corresponding to the working parameter, can also display the airway parameter, and can reset the parameter setting interface displayed in the interaction module 110, and the embodiment does not limit this. Optionally, the respiratory parameter measurement system 100 further includes a storage module; the detection module 140 and the central processing module 150 are in communication connection with the storage module; and the storage module is configured to store the sound wave detection signal and the target airway parameter.

[0078] In the embodiment, the storage module can provide storage space for the sound wave detection signal and the target airway parameter. For example, the storage module is composed of one or more memories, and the memory includes but is not limited to a read-only memory (ROM) and a random access memory (RAM). In order to guarantee the safety of data, the storage module also needs to adopt appropriate encryption and backup measures to prevent the sound wave detection signal and the target airway parameter from being lost or illegally accessed.

[0079] The technical solution of the embodiment can provide data support for the central processing module 150 to process the sound wave detection signal and the target airway parameter, and guarantee the normal operation of the respiratory parameter measurement system 100.

[0080] In some embodiments, the respiratory parameter measurement system 100 further includes a power supply module, which is configured to supply power to one or more of the interaction module 110, the excitation generation module 120, the interface module 130, the detection module 140 and the central processing module 150. For example, the power supply module supplies power to the detection module 140, the excitation generation module 120, the display module, the central processing module 150, the interaction module 110 and the communication module when the power supply is turned on, and controls the respiratory parameter measurement system 100 to start. The central processing module 150 responds to the start operation of the respiratory parameter measurement system 100, sends a welcome interface to the interaction module 110 through the communication module, controls the interaction module 110 to display a parameter setting interface, and controls the excitation generation module 120 to generate a conjugate sound wave signal according to the working parameter.

[0081] In some embodiments, the interaction module 110 is configured on the mobile terminal; accordingly, the respiratory parameter measurement system 100 further comprises a communication module, which is in wireless communication connection with the interaction module 110 and in wired communication connection with the central processing module 150; the communication module is configured to receive the working parameters wirelessly transmitted by the interaction module 110, and transmit the working parameters to the central processing module 150, and wirelessly transmit the processing information generated by the central processing module 150 to the interaction module 110; the interaction module 110 displays the received processing information on an information display interface; wherein the processing information includes but is not limited to airway parameters and alarm information, and the information display interface is an interface for displaying the processing information.

[0082] In some embodiments, the interaction module 110 can also be configured on the surface of the excitation generation module 120, the interface module 130, the detection module 140 or the central processing module 150.

[0083] Exemplarily, it is assumed that the respiratory parameter measurement system 100 has two working modes, i.e., a target airway parameter detection working mode and an end working mode, wherein the target airway parameter detection working mode includes a detection sub-mode and an analysis sub-mode. In the detection sub-mode, the interface module 130 loads the acquired detection sound wave signal to the measured sample, wherein the detection sound wave signal is a conjugate sound wave signal; the central processing module 150 sends a detection control signal to the detection module 140 to control the detection module 140 to detect the return sound wave of the airway pipeline 160 and acquire the sound wave detection signal obtained by the detection module 140 under the condition that it is determined that air leakage does not occur. In the analysis sub-mode, the central processing module 150 determines the target airway parameter corresponding to the measured sample according to the sound wave detection signal, and sends the target airway parameter to the display module under the condition that the target airway parameter meets the preset parameter range. If the setting parameter of the working mode setting item acquired by the interaction module 110 corresponds to the detection working mode, the central processing module 150 controls the air leakage sensor of the interface module 130 to detect the air leakage condition, and in some embodiments, the interface module 130 is in communication connection with the central processing module 150 through the detection module 140, the central processing module 150 generates an air leakage detection control signal and sends the air leakage detection control signal to the detection module 140 to control the detection module 140 to collect the air leakage signal detected by the air leakage sensor and transmit the air leakage signal to the central processing module 150, so that the respiratory parameter measurement system 100 enters the detection sub-mode; in the detection sub-mode, the central processing module 150 controls the respiratory parameter measurement system 100 to enter the analysis sub-mode in response to receiving the sound wave detection signal; in the analysis sub-mode, if the current detection state is that the central processing module 150 sends the target airway parameter to the display module, it can be considered that the target airway parameter detection is completed, then the central processing module 150 generates a stop detection control signal and sends the stop detection control signal to the excitation generation module 120 and the detection module 140 to control the respiratory parameter measurement system 100 to enter the end working mode. If the setting parameter of the working mode setting item acquired by the interaction module 110 corresponds to the end working mode, the central processing module 150 generates a stop detection control signal and sends the stop detection control signal to the excitation generation module 120 and the detection module 140 to control the respiratory parameter measurement system 100 to enter the end working mode.

[0084] The technical scheme of the embodiment provides a respiratory parameter measurement system 100, which comprises an interaction module 110, an excitation generation module 120, an interface module 130, a detection module 140 and a central processing module 150; the excitation generation module 120 and the interface module 130 are connected through an airway pipeline 160, the interaction module 110 and the interface module 130 are respectively in communication connection with the central processing module 150, and the detection module 140 is in communication connection with the central processing module 150; wherein the interaction module 110 is used for displaying a parameter setting interface, acquiring target working parameters set based on the parameter setting interface, and transmitting the target working parameters to the central processing module 150; the central processing module 150 is used for, in the case that the target working parameters comprise first working parameters, controlling the excitation generation module 120 to generate a detection sound wave signal according to the first working parameters, and generating a detection control signal according to the first working parameters and sending the detection control signal to the detection module 140; wherein the first working parameters comprise an initial frequency, a linear modulation index and a transmission pulse period; the interface module 130 is used for acquiring the detection sound wave signal generated by the excitation generation module 120, loading the detection sound wave signal to a measured sample through the airway pipeline 160, collecting a return sound wave corresponding to the detection sound wave signal, and loading the return sound wave to the airway pipeline 160; the detection module 140 is used for receiving the detection control signal and detecting the return sound wave of the airway pipeline 160 according to the detection control signal to obtain a sound wave detection signal; and the central processing module 150 is further used for receiving the sound wave detection signal and determining target airway parameters corresponding to the measured sample according to the sound wave detection signal. The excitation generation module 120 can encode the sound wave excitation for detecting the respiratory parameter based on the first working parameters, so that the detection module 140 can detect the sound wave detection signal corresponding to the detection sound wave signal of multiple frequencies, and compared with the sound wave detection signal corresponding to the detection sound wave signal of a single frequency, more frequency information can be acquired based on the sound wave detection signal corresponding to the detection sound wave signal of multiple frequencies, which is helpful to improve the respiratory parameter measurement precision.

[0085] Embodiment two

[0086] As Figure 1 shown, the technical scheme of the embodiment of the application is further optimized on the basis of any of the above embodiments, so that the respiratory parameter measurement system 100 can detect the sputum existence state. The specific implementation can be seen from the description of the embodiment.

[0087] In the embodiment, the sputum existence state is the existence state of sputum in the respiratory system of the measured object, wherein the sputum existence state comprises sputum existence and sputum nonexistence. It should be noted that if there is sputum in the respiratory system of the measured object, the respiratory parameter measurement system 100 can drive the sputum to move, so as to cause the target airway parameters acquired to change.

[0088] The respiratory parameter measurement system 100 can specifically include an interaction module 110, an excitation generation module 120, an interface module 130, a detection module 140, and a central processing module 150. Among them, the excitation generation module 120 and the interface module 130 are connected through the airway pipeline 160, the interaction module 110 and the interface module 130 are respectively in communication connection with the central processing module 150, and the detection module 140 is in communication connection with the central processing module 150.

[0089] The central processing module 150 is also configured to, when the target working parameter includes the second working parameter, control the excitation generation module 120 to generate the sputum-removing oscillation wave signal according to the second working parameter.

[0090] The second working parameter includes a preset amplitude, a preset frequency, and a preset duration.

[0091] In this embodiment, the second working parameter is a parameter for setting the attribute of the sputum-removing oscillation wave signal, wherein the sputum-removing oscillation wave signal is a fixed frequency signal with attribute set based on the second working parameter in the target working parameter, and the sputum-removing oscillation wave signal can drive the sputum to move in the respiratory system. It should be noted that when the target working parameter includes the second working parameter, the target working parameter also includes the first working parameter, and the target mechanical wave signal also includes the detection control signal when including the sputum-removing oscillation wave signal.

[0092] Specifically, the central processing module 150 identifies the second working parameter in the received target working parameter, and when the second working parameter is identified, the central processing module 150 sends the second working parameter to the excitation generation module 120 after controlling the excitation generation module 120 to stop generating the detection control signal, to control the excitation generation module 120 to generate the sputum-removing oscillation wave signal corresponding to the second working parameter. The preset amplitude is a fixed amplitude set by the user based on the interaction module 110, for example, the preset amplitude is 15 volts, and the preset amplitude is between 0 volts and 20 volts; the preset frequency is a fixed frequency set by the user based on the interaction module 110, for example, the preset frequency is 20 hertz, and the preset frequency is between 5 hertz and 25 hertz; and the preset duration is the duration of the excitation generation module 120 for continuously generating the sputum-removing oscillation wave signal set by the user based on the interaction module 110, for example, the preset duration is 5 minutes, and the preset duration is between 0.5 minutes and 10 minutes.

[0093] The interface module 130 is also configured to obtain the sputum-removing oscillation wave signal generated by the excitation generation module 120 and load the sputum-removing oscillation wave signal to the measured sample through the airway pipeline 160.

[0094] Specifically, the excitation generation module 120 sends the sputum-removing oscillation wave signal to the airway pipeline 160. The interface module 130 receives the sputum-removing oscillation wave signal propagating along the airway pipeline 160, and transmits the received sputum-removing oscillation wave signal to the respiratory system of the measured sample, so as to drive the sputum in the respiratory system of the measured sample to move based on the sputum-removing oscillation wave signal.

[0095] For example, it is assumed that the interface module 130 includes a mask. By wearing the mask on the face of the measured sample, the interface module 130 is connected to the oral cavity of the measured sample.

[0096] The central processing module 150 is also configured to acquire a target airway parameter before the sputum-removing oscillation wave signal is loaded to the measured sample as a first airway parameter, acquire a target airway parameter after the sputum-removing oscillation wave signal is stopped being loaded to the measured sample as a second airway parameter, and determine the sputum existence state corresponding to the measured sample based on difference information of the first airway parameter and the second airway parameter and a preset difference condition.

[0097] Specifically, the first airway parameter is a target airway parameter acquired before the second airway parameter. The respiratory parameter measurement system 100 detects the target airway parameter of the measured sample before driving the sputum of the measured sample based on the sputum-removing oscillation wave signal, and the central processing module 150 determines the obtained target airway parameter as the first airway parameter. The respiratory parameter measurement system 100 detects the target airway parameter of the measured sample again after driving the sputum of the measured sample based on the sputum-removing oscillation wave signal, and the central processing module 150 determines the obtained target airway parameter as the second airway parameter. By analyzing the difference between the first airway parameter and the second airway parameter, the difference information of the first airway parameter and the second airway parameter is obtained. For example, the difference information includes, but is not limited to, resonance frequency difference information, respiratory impedance frequency difference information, and respiratory reactance frequency difference information.

[0098] By comparing the difference information with the preset difference condition, in the case that the difference information meets the preset difference condition, it can be considered that the sputum moving is driven by the sputum driving oscillation wave signal, and it is determined that the sputum existing state corresponding to the measured sample is sputum existing; in the case that the difference information does not meet the preset difference condition, it can be considered that the sputum moving is not driven by the sputum driving oscillation wave signal, and it is determined that the sputum existing state corresponding to the measured sample is sputum non-existing. The preset difference condition is a condition of the difference information preset for determining that the sputum existing state corresponding to the measured sample is sputum existing. Optionally, the preset difference condition includes at least one of the following: the absolute difference value between the first resonance frequency corresponding to the first airway parameter and the second resonance frequency corresponding to the second airway parameter is greater than a preset frequency threshold; the correlation coefficient of the first respiratory impedance frequency curve corresponding to the first airway parameter and the second respiratory impedance frequency curve corresponding to the second airway parameter is less than a preset respiratory impedance coefficient threshold; the correlation coefficient of the first respiratory reactance frequency curve corresponding to the first airway parameter and the second respiratory reactance frequency curve corresponding to the second airway parameter is less than a preset respiratory impedance coefficient threshold; the variation rate of the first respiratory impedance corresponding to the first airway parameter and the second respiratory impedance corresponding to the second airway parameter is greater than or equal to a preset variation rate threshold.

[0099] Specifically, the first resonance frequency is a resonance frequency determined based on the first airway parameter; and the second resonance frequency is a resonance frequency determined based on the second airway parameter. By calculating the absolute difference value between the first resonance frequency and the second resonance frequency, and comparing the absolute difference value with a preset frequency threshold, wherein the preset frequency threshold is a threshold of the absolute difference value between the first resonance frequency and the second resonance frequency preset for determining that the preset difference condition is met. In the case that the absolute difference value is greater than the preset frequency threshold, it is determined that the difference information of the first airway parameter and the second airway parameter meets the preset difference condition. Exemplarily, the preset frequency threshold is 5 Hz.

[0100] The first respiratory impedance frequency curve is a frequency curve plotted based on the respiratory impedance frequency of the first airway parameter; and the second respiratory impedance frequency curve is a frequency curve plotted based on the respiratory impedance frequency of the second airway parameter. By calculating the correlation coefficient of the first respiratory impedance frequency curve and the second respiratory impedance frequency curve, and comparing the correlation coefficient with a preset respiratory impedance coefficient threshold, wherein the preset respiratory impedance coefficient threshold is a threshold of the correlation coefficient of the first respiratory impedance frequency curve and the second respiratory impedance frequency curve preset for determining that the preset difference condition is met. In the case that the correlation coefficient of the first respiratory impedance frequency curve and the second respiratory impedance frequency curve is less than the preset respiratory impedance coefficient threshold, it is determined that the difference information of the first airway parameter and the second airway parameter meets the preset difference condition.

[0101] Exemplarily, the correlation coefficient of the first respiratory impedance frequency curve and the second respiratory impedance frequency curve is r2 = (A p A q + B p B q ) 2 + (A p A q - B p B q ) 2 / (p t * q t ), wherein A p = p t cos [θ (p t )], A q = q t cos [θ (q t )], B p = p t sin [θ (p t )], B q = q t sin [θ (q t )], and the preset respiratory reactance coefficient threshold is 80%.

[0102] The first respiratory reactance frequency curve is a frequency curve plotted based on the respiratory reactance frequencies determined based on the first airway parameter; and the second respiratory reactance frequency curve is a frequency curve plotted based on the respiratory reactance frequencies determined based on the second airway parameter. The correlation coefficient of the first respiratory reactance frequency curve and the second respiratory reactance frequency curve is calculated, and the correlation coefficient is compared with a preset respiratory reactance coefficient threshold, wherein the preset respiratory reactance coefficient threshold is a threshold of the correlation coefficient of the first respiratory reactance frequency curve and the second respiratory reactance frequency curve, and is used to determine whether the difference information of the first airway parameter and the second airway parameter meets the preset difference condition. In a case where the correlation coefficient of the first respiratory reactance frequency curve and the second respiratory reactance frequency curve is less than the preset respiratory reactance coefficient threshold, it is determined that the difference information of the first airway parameter and the second airway parameter meets the preset difference condition. Exemplarily, the preset respiratory reactance coefficient threshold is 80%.

[0103] The first respiratory reactance is determined based on the first airway parameter; and the second respiratory reactance is determined based on the second airway parameter. The variation rate of the first respiratory reactance and the second respiratory reactance is calculated, and the variation rate is compared with a preset variation rate threshold, wherein the preset variation rate threshold is a threshold of the variation rate of the first respiratory reactance and the second respiratory reactance, and is used to determine whether the difference information of the first airway parameter and the second airway parameter meets the preset difference condition. In a case where the variation rate of the first respiratory reactance and the second respiratory reactance is greater than or equal to the preset variation rate threshold, it is determined that the difference information of the first airway parameter and the second airway parameter meets the preset difference condition.

[0104] For example, the variation rate of the first respiratory impedance and the second respiratory impedance Cov = [(R 51 -R 50 ) 2 +(R 52 -R 50 ) 2 ] 12 ×100%, wherein R 51 represents the first respiratory impedance determined when the frequency of the detected acoustic wave signal is 5 Hz, R 52 represents the second respiratory impedance determined when the frequency of the detected acoustic wave signal is 5 Hz, R 50 = (R 51 + R 52 ) / 2, and the preset variation rate threshold is 20%.

[0105] The technical scheme of the embodiment sets the preset difference condition based on any one of the absolute difference value of the first resonance frequency and the second resonance frequency, the correlation coefficient of the first respiratory impedance frequency curve and the second respiratory impedance frequency curve, the correlation coefficient of the first respiratory reactance frequency curve and the second respiratory reactance frequency curve, and the variation rate of the first respiratory impedance and the second respiratory impedance, improves the difference information based on the first airway parameter and the second airway parameter and the preset difference condition, and determines the accuracy of the sputum existence state corresponding to the measured sample, which helps to reduce the possibility of false judgment of the sputum existence state.

[0106] The technical scheme of the embodiment provides a respiratory parameter measurement system 100, which comprises an interaction module 110, an excitation generation module 120, an interface module 130, a detection module 140 and a central processing module 150; the excitation generation module 120 and the interface module 130 are connected through an airway pipeline 160, the interaction module 110 and the interface module 130 are respectively in communication connection with the central processing module 150, and the detection module 140 is in communication connection with the central processing module 150; wherein the central processing module 150 is further used for, in the case that the target working parameter comprises a second working parameter, controlling the excitation generation module 120 to generate a sputum-removing oscillation wave signal according to the second working parameter, wherein the second working parameter comprises a preset amplitude, a preset frequency and a preset duration; the interface module 130 is further used for acquiring the sputum-removing oscillation wave signal generated by the excitation generation module 120 and loading the sputum-removing oscillation wave signal to the measured sample through the airway pipeline 160; the central processing module 150 is further used for acquiring a target airway parameter before the sputum-removing oscillation wave signal is loaded to the measured sample as a first airway parameter, acquiring a target airway parameter after the sputum-removing oscillation wave signal stops being loaded to the measured sample as a second airway parameter, and determining a sputum existence state corresponding to the measured sample based on difference information of the first airway parameter and the second airway parameter and a preset difference condition; the sputum existence state comprises sputum existence and sputum nonexistence. By removing sputum from the respiratory system of the measured object based on the sputum-removing oscillation wave signal, the central processing module 150 can determine the sputum existence state corresponding to the measured sample based on the first airway parameter and the second airway parameter, without the active cooperation of the measured object in breathing, so that the accurate sputum existence state can be determined, and the convenience of sputum existence state determination and the practicality of the respiratory parameter measurement system 100 are improved.

[0107] Embodiment three

[0108] Figure 2 is a flowchart of a respiratory parameter measurement method provided by the embodiment three of the application. As shown in the figure, Figure 2 the method comprises the following steps.

[0109] In S310, a parameter setting interface is displayed based on the interaction module, target working parameters set based on the parameter setting interface are acquired, and the target working parameters are transmitted to the central processing module.

[0110] In S320, the central processing module controls the excitation generation module to generate a detection sound wave signal according to a first working parameter in the case that the target working parameter comprises the first working parameter, generates a detection control signal according to the first working parameter, and sends the detection control signal to the detection module; wherein the first working parameter comprises an initial frequency, a linear modulation index and a transmission pulse period.

[0111] S330, based on the interface module, obtaining the detection sound wave signal generated by the excitation generation module, and loading the detection sound wave signal to the measured sample through the airway pipeline, and collecting the return sound wave corresponding to the detection sound wave signal and loading the return sound wave to the airway pipeline.

[0112] S340, based on the detection module receiving the detection control signal, and detecting the return sound wave of the airway pipeline according to the detection control signal to obtain the sound wave detection signal.

[0113] S350, based on the center processing module receiving the sound wave detection signal, and determining the target airway parameter corresponding to the measured sample according to the sound wave detection signal.

[0114] Wherein, the excitation generation module and the interface module are connected through the airway pipeline, the interaction module and the interface module are respectively connected with the center processing module in communication, and the detection module is connected with the center processing module in communication.

[0115] On the basis of the above embodiment, optionally, according to the sound wave detection signal, the target airway parameter corresponding to the measured sample is determined, including: in the case that the detection sound wave signal is a conjugate sound wave signal, the sound wave detection signal and the detection sound wave signal are convolved and complex conjugate calculation processing is performed to obtain a target detection signal, and the target airway parameter is determined based on the target detection signal.

[0116] On the basis of the above embodiment, optionally, the respiratory parameter measurement method further comprises: based on the center processing module, in the case that the target working parameter comprises a second working parameter, controlling the excitation generation module to generate a sputum-removing oscillation wave signal according to the second working parameter, wherein the second working parameter comprises a preset amplitude, a preset frequency and a preset duration; based on the interface module, obtaining the sputum-removing oscillation wave signal generated by the excitation generation module and loading the sputum-removing oscillation wave signal to the measured sample through the airway pipeline; based on the center processing module, obtaining the target airway parameter before the sputum-removing oscillation wave signal is loaded to the measured sample to drive sputum as a first airway parameter, and obtaining the target airway parameter after the sputum-removing oscillation wave signal is stopped to be loaded to the measured sample as a second airway parameter, based on the difference information of the first airway parameter and the second airway parameter and the preset difference condition, determining the sputum existence state corresponding to the measured sample; the sputum existence state includes sputum existence and sputum nonexistence.

[0117] On the basis of the above-mentioned embodiments, optionally, the preset difference condition comprises at least one of the following: an absolute difference between a first resonant frequency corresponding to the first airway parameter and a second resonant frequency corresponding to the second airway parameter is greater than a preset frequency threshold; a correlation coefficient between a first respiratory impedance frequency curve corresponding to the first airway parameter and a second respiratory impedance frequency curve corresponding to the second airway parameter is less than a preset respiratory impedance coefficient threshold; a correlation coefficient between a first respiratory reactance frequency curve corresponding to the first airway parameter and a second respiratory reactance frequency curve corresponding to the second airway parameter is less than a preset respiratory impedance coefficient threshold; a variation rate of a first respiratory impedance corresponding to the first airway parameter and a second respiratory impedance corresponding to the second airway parameter is greater than or equal to a preset variation rate threshold.

[0118] On the basis of the above-mentioned embodiments, optionally, the interface module comprises a gas leakage sensor; correspondingly, the respiratory parameter measurement method further comprises: detecting the gas leakage condition of the interface module based on the gas leakage sensor to obtain a gas leakage signal, and transmitting the gas leakage signal to the central processing module; determining whether gas leakage occurs based on the central processing module according to the received gas leakage signal; and in the case where no gas leakage occurs within a preset time length, sending the detection control signal to the detection module.

[0119] On the basis of the above-mentioned embodiments, optionally, the respiratory parameter measurement method further comprises: comparing the target airway parameter with a preset parameter range based on the central processing module, in the case where the target airway parameter meets the preset parameter range, sending the target airway parameter to the display module, and in the case where the target airway parameter does not meet the preset parameter range, generating an alarm information and sending the alarm information to the display module; based on the display module receiving the target airway parameter and / or the alarm information, and displaying the target airway parameter and / or the alarm information; wherein the display module and the central processing module are in communication connection.

[0120] On the basis of the above-mentioned embodiments, optionally, the interaction module comprises an interface setting sub-module and a parameter conversion sub-module; correspondingly, the parameter setting interface is displayed based on the interaction module, and the target working parameter set based on the parameter setting interface is obtained, and the target working parameter is transmitted to the central processing module, comprising: the parameter setting interface is displayed based on the interface setting sub-module, and the parameter setting item is displayed in the parameter setting interface, wherein the parameter setting item comprises a working mode setting item; the target working mode is determined based on the setting parameter of the working mode setting item based on the parameter conversion sub-module, the target working parameter is determined according to the target working mode, and the target working parameter is transmitted to the central processing module.

[0121] On the basis of the above-mentioned embodiment, optionally, the respiratory parameter measurement method further comprises: based on the central processing module, in the case of detecting that the preset stop detection condition is reached, controlling the excitation generation module to stop outputting the conjugate sound wave signal, and controlling the detection module to stop detecting the return sound wave of the airway pipeline.

[0122] On the basis of the above-mentioned embodiment, optionally, the respiratory parameter measurement method further comprises: based on the storage module, storing the sound wave detection signal and the target airway parameter; wherein the detection module and the central processing module are respectively in communication connection with the storage module.

[0123] The technical scheme of the embodiment, by displaying the parameter setting interface based on the interaction module, and obtaining the target working parameter set based on the parameter setting interface, and transmitting the target working parameter to the central processing module; based on the central processing module, in the case of the target working parameter including the first working parameter, generating the detection sound wave signal according to the first working parameter, and generating the detection control signal according to the first working parameter, and sending the detection control signal to the detection module; wherein the first working parameter includes the initial frequency, the linear modulation index and the transmission pulse period; based on the interface module, obtaining the detection sound wave signal generated by the excitation generation module, and loading the detection sound wave signal to the measured sample through the airway pipeline, and collecting the return sound wave corresponding to the detection sound wave signal, and loading the return sound wave to the airway pipeline; based on the detection module, receiving the detection control signal, and detecting the return sound wave of the airway pipeline according to the detection control signal to obtain the sound wave detection signal; based on the central processing module, receiving the sound wave detection signal, and determining the target airway parameter corresponding to the measured sample according to the sound wave detection signal; wherein the excitation generation module and the interface module are connected through the airway pipeline, the interaction module and the interface module are respectively in communication connection with the central processing module, and the detection module is in communication connection with the central processing module. By frequency encoding the sound wave excitation for detecting the respiratory parameter based on the first working parameter, the detection module can detect the sound wave detection signal corresponding to the detection sound wave signal of multiple frequencies, compared with the sound wave detection signal corresponding to the detection sound wave signal of a single frequency, more frequency information can be obtained based on the sound wave detection signal corresponding to the detection sound wave signal of multiple frequencies, which helps to improve the respiratory parameter measurement accuracy.

[0124] It should be understood that the various forms of flow shown above can be used to reorder, add or delete steps. For example, each step described in the present application can be executed in parallel, sequentially or in a different order, as long as the desired results of the technical scheme of the present application can be achieved, which is not limited herein.

[0125] The above detailed description does not limit the scope of the application. Various modifications, combinations, sub-combinations and alternatives can be made to the detailed description. Any modification, equivalent replacement and improvement etc. made within the spirit and principle of the application shall be included in the scope of the application.

Claims

1. A respiratory parameter measurement system, characterized by, The application relates to a center processing module, an interface module, an interaction module, an excitation generation module and a detection module. The excitation generation module and the interface module are connected through an airway pipeline, the interaction module and the interface module are respectively connected with the center processing module in communication, and the detection module is connected with the center processing module in communication. The interaction module is used for displaying a parameter setting interface, obtaining target working parameters set based on the parameter setting interface, and transmitting the target working parameters to the center processing module. The center processing module is used for controlling the excitation generation module to generate a detection sound wave signal according to the first working parameters when the target working parameters include the first working parameters, and generating a detection control signal according to the first working parameters and sending the detection control signal to the detection module; wherein the first working parameters include an initial frequency, a linear modulation index and a transmission pulse period. The interface module is used for obtaining the detection sound wave signal generated by the excitation generation module, loading the detection sound wave signal to a measured sample through the airway pipeline, collecting a return sound wave corresponding to the detection sound wave signal, and loading the return sound wave to the airway pipeline. The detection module is used for receiving the detection control signal and detecting the return sound wave of the airway pipeline according to the detection control signal to obtain a sound wave detection signal. The center processing module is further used for receiving the sound wave detection signal and determining target airway parameters corresponding to the measured sample according to the sound wave detection signal. The interface module is further used for obtaining the drive sputum oscillation wave signal generated by the excitation generation module and loading the drive sputum oscillation wave signal to the measured sample through the airway pipeline. The center processing module is further used for obtaining a target airway parameter before the drive sputum oscillation wave signal is loaded to the measured sample as a first airway parameter, obtaining a target airway parameter after the drive sputum oscillation wave signal is stopped from being loaded to the measured sample as a second airway parameter, determining a sputum existence state corresponding to the measured sample based on difference information of the first airway parameter and the second airway parameter and a preset difference condition; and the sputum existence state includes sputum existence and sputum nonexistence. The center processing module is specifically used for performing convolution complex conjugate calculation processing on the sound wave detection signal and the detection sound wave signal to obtain a target detection signal when the detection sound wave signal is a conjugate sound wave signal, and determining the target airway parameter based on the target detection signal. The preset difference condition includes at least one of the following:

2. The system of claim 1, wherein, An absolute difference value between a first resonance frequency corresponding to the first airway parameter and a second resonance frequency corresponding to the second airway parameter is greater than a preset frequency threshold.

3. The system of claim 1, wherein, ​ ​ A correlation coefficient between a first respiratory impedance frequency curve corresponding to the first airway parameter and a second respiratory impedance frequency curve corresponding to the second airway parameter is less than a preset respiratory impedance coefficient threshold value. A correlation coefficient between a first respiratory reactance frequency curve corresponding to the first airway parameter and a second respiratory reactance frequency curve corresponding to the second airway parameter is less than a preset respiratory impedance coefficient threshold value. A variation rate of a first respiratory impedance corresponding to the first airway parameter and a second respiratory impedance corresponding to the second airway parameter is greater than or equal to a preset variation rate threshold value.

4. The system of claim 1, wherein, The interface module comprises a gas leakage sensor; wherein The gas leakage sensor is configured to detect a gas leakage condition of the interface module, obtain a gas leakage signal, and transmit the gas leakage signal to the central processing module. The central processing module is further configured to determine whether gas leakage occurs based on the received gas leakage signal, and send the detection control signal to the detection module in a case where no gas leakage occurs within a preset time length.

5. The system of claim 1, wherein, The respiratory parameter measurement system further comprises a display module; the display module is in communication connection with the central processing module; wherein The central processing module is further configured to compare the target airway parameter with a preset parameter range, send the target airway parameter to the display module in a case where the target airway parameter meets the preset parameter range, and generate an alarm information and send the alarm information to the display module in a case where the target airway parameter does not meet the preset parameter range. The display module is configured to receive the target airway parameter and / or the alarm information, and display the target airway parameter and / or the alarm information.

6. The system of claim 1, wherein, The interaction module comprises an interface setting sub-module and a parameter conversion sub-module; wherein The interface setting sub-module is configured to display a parameter setting interface, and display a parameter setting item in the parameter setting interface, wherein the parameter setting item comprises a working mode setting item; The parameter conversion sub-module is configured to determine a target working mode based on a setting parameter of the working mode setting item, determine a target working parameter according to the target working mode, and transmit the target working parameter to the central processing module.

7. The system of claim 1, wherein, The central processing module is further configured to control the excitation generation module to stop generating the detection sound wave signal and control the detection module to stop detecting the return sound wave of the airway pipeline in a case where detection reaches a preset stop detection condition.

8. The system of claim 1, wherein, The respiratory parameter measurement system further comprises a storage module; the detection module and the central processing module are in communication connection with the storage module; wherein The storage module is configured to store the sound wave detection signal and the target airway parameter.

9. A method of measuring a respiratory parameter, characterized by, The method comprises: displaying a parameter setting interface based on the interaction module, obtaining a target working parameter set based on the parameter setting interface, and transmitting the target working parameter to the central processing module; based on the central processing module, in a case where the target working parameter comprises a first working parameter, controlling the excitation generation module to generate a detection sound wave signal according to the first working parameter, and generating a detection control signal according to the first working parameter and sending the detection control signal to the detection module; wherein the first working parameter comprises an initial frequency, a linear modulation index, and a transmission pulse period; based on the interface module, acquiring the detection sound wave signal generated by the excitation generation module and loading the detection sound wave signal to the measured sample through an airway pipeline, and collecting a return sound wave corresponding to the detection sound wave signal and loading the return sound wave to the airway pipeline; based on the detection module, receiving the detection control signal and detecting the return sound wave of the airway pipeline according to the detection control signal to obtain a sound wave detection signal; based on the central processing module, receiving the sound wave detection signal and determining a target airway parameter corresponding to the measured sample according to the sound wave detection signal; wherein the excitation generation module and the interface module are connected through an airway pipeline, the interaction module and the interface module are respectively in communication connection with the central processing module, and the detection module is in communication connection with the central processing module; the method further comprises: based on the central processing module, in a case where the target working parameter comprises a second working parameter, controlling the excitation generation module to generate a sputum-removing oscillation wave signal according to the second working parameter, wherein the second working parameter comprises a preset amplitude, a preset frequency, and a preset duration; based on the interface module, acquiring the sputum-removing oscillation wave signal generated by the excitation generation module and loading the sputum-removing oscillation wave signal to the measured sample through the airway pipeline; based on the central processing module, acquiring a target airway parameter before the sputum-removing oscillation wave signal is loaded to the measured sample to remove sputum as a first airway parameter, acquiring a target airway parameter after the sputum-removing oscillation wave signal is stopped being loaded to the measured sample as a second airway parameter, and determining a sputum existence state corresponding to the measured sample based on difference information of the first airway parameter and the second airway parameter and a preset difference condition; the sputum existence state comprises sputum existence and sputum nonexistence.

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