Simulation system and simulation method for measuring the effect of transcranial alternating current stimulation

Abstract

The present invention discloses a simulation system and a simulation method for measuring the effect of transcranial alternating current stimulation. The simulation system includes: a processor, on which a human-machine interactive operation interface is provided to select a stimulation electrode mode for performing alternating current stimulation simulation, in which the sum of the current amplitudes of each electrode in the stimulation electrode mode is zero at any time, including a first stimulation mode; the first stimulation mode is configured such that the number of positive stimulation electrodes or negative stimulation electrodes is 1; a direct current construction module, which extracts the amplitude of the stimulation current of the first stimulation mode at a certain moment to construct a direct current stimulation result; and an effect simulation module, which is used to map the direct current stimulation result to the effect simulation result of alternating current stimulation at all times. The present invention can shorten the calculation time of the simulation result of tACS, improve the simulation efficiency, and can also be applied to the effect simulation of complex stimulation schemes.

Description

Technical Field

[0001] The present invention relates to the field of measurement and testing technology, and in particular to a simulation system and a simulation method for measuring the effect of transcranial alternating current stimulation. Background Art

[0002] Transcranial alternating current stimulation (tACS) is a non-invasive brain stimulation technology. It is widely used in the medical field because of its safety, low cost and portability. This technology is also increasingly valued in the treatment of depressive disorders. tACS uses electrodes placed on the scalp to apply low-intensity alternating current of a specific frequency to the target brain area, thereby regulating the activity of the cerebral cortex nerves and improving depression.

[0003] In practical applications, it is necessary to simulate and test the effects of transcranial alternating current stimulation to improve the stimulation effect and safety of subsequent implementation. Since the current of alternating current varies with time, and the location and intensity of stimulation can be changed according to the needs of treatment, the simulation of the effect of tACS is very complicated. At present, the existing methods for simulating tACS require real-time calculation of the simulation results at each moment, which results in a long calculation time and low simulation efficiency. Summary of the invention

[0004] The technical problem to be solved by the present invention is: how to classify and obtain the simulation results of the effect of transcranial alternating current stimulation based on the simulation method of the effect of transcranial direct current stimulation. To this end, the present invention provides a simulation system and a simulation method for measuring the effect of transcranial alternating current stimulation.

[0005] The technical solution adopted by the present invention to solve the technical problem is: a simulation system for measuring the effect of transcranial alternating current stimulation, comprising:

[0006] A processor having a human-machine interactive operation interface for selecting a stimulation electrode mode for performing alternating current stimulation simulation, wherein the sum of the current amplitudes of the electrodes in the stimulation electrode mode is zero at any time, including a first stimulation mode; the first stimulation mode is configured such that the number of positive stimulation electrodes or negative stimulation electrodes is 1;

[0007] A direct current construction module extracts the amplitude of the stimulation current of the first stimulation mode at a certain moment to construct a direct current stimulation result;

[0008] The effect simulation module is used to map the DC stimulation result into the effect simulation result of AC stimulation at all times.

[0009] Furthermore, the DC building module includes:

[0010] The amplitude of the stimulation current of the first stimulation mode at a certain moment is extracted and input into the direct current stimulation simulation model to construct a direct current stimulation result; the direct current stimulation result includes the spatial distribution of the stimulation electric field intensity.

[0011] Furthermore, the amplitude at a certain moment is the point where the absolute amplitude of the stimulation current is maximum.

[0012] Furthermore, the effect simulation module includes:

[0013] According to the current amplitude ratio of the AC stimulation, the DC stimulation result is mapped to other moments to obtain the effect simulation result of the stimulation mode at all times; the effect simulation result includes the spatial distribution of the stimulation electric field intensity at all times.

[0014] Furthermore, the stimulation electrode mode also includes: a second stimulation mode and a third stimulation mode;

[0015] The second stimulation mode is configured as positive stimulation electrodes and negative stimulation electrodes having the same frequency and a number greater than 1;

[0016] The third stimulation mode is configured as positive stimulation electrodes and negative stimulation electrodes with different frequencies and a number greater than 1;

[0017] The simulation system further includes: a grouping module, which groups the second stimulation pattern or the third stimulation pattern into a plurality of first stimulation patterns.

[0018] Furthermore, the basis for grouping the second stimulation mode includes: the absolute values ​​of the initial phases of the currents of the stimulation electrodes are the same, and the sum of the current amplitudes of the stimulation electrodes is zero;

[0019] The basis for grouping the third stimulation mode includes: the frequencies of the stimulation electrodes are the same, the absolute values ​​of the initial phases of the currents of the stimulation electrodes are the same, and the sum of the current amplitudes of the stimulation electrodes is zero.

[0020] Furthermore, the priority of the grouping is: the frequencies of the stimulation electrodes are the same>the absolute values ​​of the initial phases of the currents of the stimulation electrodes are the same>the sum of the current amplitudes of the stimulation electrodes is zero.

[0021] Furthermore, for stimulation electrodes that are not successfully grouped, the stimulation current on the stimulation electrodes is divided into a plurality of minimum current units and then grouped according to the sum of the amplitudes being zero.

[0022] Further, it also includes: an integration module;

[0023] When the selected stimulation electrode mode is the second stimulation mode or the third stimulation mode, the effect simulation results of each stimulation mode are superimposed.

[0024] Furthermore, it also includes: a prompt module;

[0025] When the processor determines that there is a current amplitude and a stimulation pattern that is not zero, it indicates that the stimulation electrode parameters are incorrect.

[0026] Furthermore, it also includes: a phase correction module;

[0027] The phase correction module corrects the initial phase of the stimulation electrode before executing the simulation so that the initial phase falls within the interval [0,180).

[0028] In a second aspect, the present invention further provides a simulation method for determining the effect of transcranial alternating current stimulation, using the simulation system, the method comprising:

[0029] Selecting a stimulation electrode mode for performing alternating current stimulation simulation through a human-computer interaction operation interface, wherein the sum of the current amplitudes of the electrodes in the stimulation electrode mode is zero, including a first stimulation mode; wherein the first stimulation mode is configured such that the number of positive stimulation electrodes or negative stimulation electrodes is 1;

[0030] Extracting the amplitude of the stimulation current of the first stimulation mode at a certain moment to construct a direct current stimulation result;

[0031] The direct current stimulation result is mapped to the effect simulation result of the alternating current stimulation at all times.

[0032] The beneficial effect of the present invention is that according to the stimulation electrode mode set by the user, the stimulation electrode mode is simplified, the DC stimulation result is obtained by classification and the DC stimulation result is mapped to the AC stimulation result, and then the classification result is linearly combined to obtain the final AC stimulation simulation result, which can significantly shorten the calculation time of the AC stimulation result and improve the simulation efficiency. The present invention can deal with simple stimulation schemes (first stimulation mode), complex stimulation schemes (second stimulation mode) and time interference stimulation schemes (third stimulation mode), and the simulation results of the effects of complex stimulation schemes and time interference stimulation schemes can also be quickly obtained. Not only is the simulation efficiency high, but also the scope of application is wide. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] The present invention is further described below in conjunction with the accompanying drawings and embodiments.

[0034] Figure 1 It is a structural schematic diagram of the simulation system of the present invention.

[0035] Figure 2 It is a schematic diagram of the simulation results of the effect of the present invention.

[0036] Figure 3 It is a schematic diagram of the change curve of the stimulation current of the present invention.

[0037] Figure 4It is a flow chart of obtaining effect simulation results in the first stimulation mode of the present invention.

[0038] Figure 5 It is a flow chart of the effect simulation results obtained in the second stimulation mode of the present invention.

[0039] Figure 6 It is a flow chart of obtaining effect simulation results under the third stimulation mode of the present invention.

[0040] Figure 7 It is a schematic diagram of the current change curve of the stimulation electrodes a~e of the present invention.

[0041] Figure 8 Schematic diagram of the stimulation current requiring phase correction according to the present invention. DETAILED DESCRIPTION

[0042] The present invention will now be described in further detail with reference to the accompanying drawings. These drawings are simplified schematic diagrams, which only illustrate the basic structure of the present invention in a schematic manner, and therefore only show the components related to the present invention.

[0043] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention. In addition, features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, unless otherwise specified, "multiple" means two or more.

[0044] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0045] like Figure 1As shown, the simulation system for measuring the effect of transcranial alternating current stimulation of the present invention includes: a processor, a DC construction module and an effect simulation module. A human-computer interaction interface is provided on the processor to select a stimulation electrode mode for performing AC stimulation simulation. The sum of the current amplitudes of each electrode in the stimulation electrode mode is zero at any time. The stimulation electrode mode includes a first stimulation mode, and the first stimulation mode is configured so that the number of positive stimulation electrodes or negative stimulation electrodes is 1. The DC construction module is used to extract the amplitude of the stimulation current of the first stimulation mode at a certain moment to construct a DC stimulation result. The effect simulation module is used to map the DC stimulation result to the effect simulation result of AC stimulation at all times. This simulation method can significantly shorten the calculation time of the AC stimulation result and improve the simulation efficiency by obtaining the DC stimulation result and mapping the DC stimulation result to the AC stimulation result.

[0046] Specifically, the human-computer interaction operation interface can select the stimulation electrode parameters, which include: the number of stimulation electrodes, the type of stimulation electrodes, the shape of stimulation electrodes, the installation position of stimulation electrodes, and the type of stimulation current on the stimulation electrodes, amplitude, frequency, initial phase, offset, stimulation time, etc., which can be set according to the simulation requirements. For example, the types of stimulation electrodes include sheet electrodes (usually with only one channel) and high-density electrodes (containing multiple channels). The shapes of stimulation electrodes include round, square, etc. The installation position of the stimulation electrode includes the relative position of the center of the electrode sheet on the head mold. The types of stimulation current include positive stimulation current and negative stimulation current. The amplitude, frequency, initial phase, and offset of the stimulation current determine what kind of deformation the stimulation current will undergo based on sin(x), where the amplitude is longitudinal stretching, the frequency is transverse stretching, the initial phase is transverse translation, and the offset is longitudinal translation. The stimulation time includes total time, time resolution, a specific moment when the result is desired, etc. For example Figure 3 As shown, positive stimulation current = amplitude * sin (frequency * time + initial phase) + offset, negative stimulation current = amplitude * cos (frequency * time + initial phase) + offset. In clinical practice, the minimum value of stimulation current is often set to be greater than zero. Therefore, if the stimulation current value is too small during simulation, it will have no effect on stimulation. Therefore, the "offset" parameter is set in the present invention to adjust the size of the stimulation current.

[0047] The DC construction module includes extracting the amplitude of the stimulation current of the first stimulation mode at a certain moment, and inputting it into the DC stimulation simulation model to construct the DC stimulation result. The DC stimulation result includes the spatial distribution of the stimulation electric field intensity. Figure 2 As shown, the spatial distribution of the stimulation electric field intensity refers to displaying the corresponding stimulation electric field intensity at different spatial positions of the brain model to facilitate observation of the stimulation effect.

[0048] For example, the amplitude at a certain moment is the point where the absolute amplitude of the stimulation current is the maximum. It should be noted that when constructing the DC stimulation results, the stimulation currents at all times are not input into the DC stimulation simulation model, but only the stimulation current corresponding to the moment with the maximum absolute amplitude is input. The reason for only inputting the point with the maximum absolute amplitude into the DC stimulation simulation model to obtain the result is that the results at other moments can be obtained by proportional mapping based on the results at this moment, and the ratio here is the ratio between the stimulation currents at two moments. This can significantly shorten the calculation time of the DC stimulation simulation model. In addition, when obtaining the point with the maximum absolute amplitude, since the alternating current applied to each stimulation electrode has the same frequency and the sum of the currents at each moment is 0, it is only necessary to calculate the current ratio on one stimulation electrode.

[0049] Specifically, the effect simulation module includes mapping the DC stimulation results to other moments according to the current amplitude ratio of the AC stimulation, and obtaining the effect simulation results of the stimulation mode at all times. The effect simulation results include the spatial distribution of the stimulation electric field intensity at all times. For example, the mapping method includes: mapping the DC stimulation result matrix X to the effect simulation result matrix Y at the moment to be obtained, according to the current amplitude A of the AC stimulation at the moment of the effect simulation result currently obtained and the current amplitude B of the AC stimulation at the moment of the effect simulation result to be obtained, where Y = X*B / A. Alternatively, the moment of the effect simulation result currently obtained is recorded as T0, and the moment of any effect simulation result to be obtained is recorded as T, and the effect simulation result matrix X(T) at the moment to be obtained is X(T0)*I(T) / I(T0), where X(T0) represents the effect simulation result matrix that has been obtained, I(T) represents the current amplitude of the AC stimulation corresponding to the moment T of any effect simulation result to be obtained, and I(T0) represents the current amplitude of the AC stimulation corresponding to the moment T0 of the effect simulation result that has been obtained. Obviously, X(T) and I(T) are quantities that change with time T or can be regarded as functions related to time. Therefore, the full-time effect simulation results of tACS can be obtained through mapping, and there is no need to calculate all the time.

[0050] The following is combined with Figure 4 The process of the first stimulation mode is described. The first stimulation mode includes three stimulation electrode situations: one positive and one negative stimulation electrode (situation one), one positive and multiple negative stimulation electrodes (situation two), and multiple positive and one negative stimulation electrodes (situation three). These three situations can be summarized as the number of positive stimulation electrodes is 1 or the number of negative stimulation electrodes is 1 (this condition can be used as a judgment condition). The relevant stimulation electrode parameters are set in the human-computer interaction operation interface, and then it is judged whether the number of positive stimulation electrodes is 1 or the number of negative stimulation electrodes is 1. If this condition is met, the first stimulation mode is executed.

[0051] In case one, the maximum absolute amplitude of the positive stimulation current or the negative stimulation current is extracted and input into the DC stimulation simulation model to obtain the DC stimulation result; according to the current amplitude ratio of the AC stimulation, the DC stimulation result is mapped to other moments to obtain the simulation result of the effect of the stimulation mode at all times.

[0052] In case 2, the point with the maximum absolute amplitude of the positive stimulation current is extracted and input into the DC stimulation simulation model to obtain the DC stimulation result; according to the current amplitude ratio of the AC stimulation, the DC stimulation result is mapped to other moments to obtain the simulation result of the effect of the stimulation mode at all times.

[0053] In case three, the point with the maximum absolute amplitude of the negative stimulation current is extracted and input into the DC stimulation simulation model to obtain the DC stimulation result; according to the current amplitude ratio of the AC stimulation, the DC stimulation result is mapped to other moments to obtain the simulation result of the effect of the stimulation mode at all times.

[0054] It should be noted that the stimulation electrode mode also includes a second stimulation mode and a third stimulation mode. The second stimulation mode is configured as positive stimulation electrodes and negative stimulation electrodes of the same frequency and the number of which is greater than 1. The third stimulation mode is configured as positive stimulation electrodes and negative stimulation electrodes of different frequencies and the number of which is greater than 1. Compared with the first stimulation mode, the second stimulation mode and the third stimulation mode are complex situations. If the multiple positive stimulation electrodes and multiple negative stimulation electrodes contained in the mode are directly input, the physical field constructed on the discrete head model is very complex, and a set of equations with a large number of parameters needs to be solved. Therefore, if the second stimulation mode or the third stimulation mode is not grouped and the effect simulation is directly performed, a huge amount of calculation will be generated, and the efficiency is very low. The first stimulation mode is simple to calculate, and the direct current stimulation result can be directly obtained and mapped at all times. Based on this, the method of the present invention is to group the complex situations of the second stimulation mode and the third stimulation mode, simplify the complex situations, convert the complex situations into multiple simple situations that can apply the processing logic of the first stimulation mode, and then linearly combine the simulation results of multiple simple situations to obtain the final simulation results. In this way, it is conducive to improving the calculation efficiency of the simulation results of complex situations.

[0055] Specifically, the simulation system also includes a grouping module and an integration module. The grouping module is used to group the second stimulation mode or the third stimulation mode into multiple first stimulation modes. When the selected stimulation electrode mode is the second stimulation mode or the third stimulation mode, the integration module is used to superimpose the effect simulation results of each stimulation mode. For example, the basis for grouping the second stimulation mode includes: the absolute value of the initial phase of the current of the stimulation electrode is the same, and the sum of the current amplitude of the stimulation electrode is zero. The basis for grouping the third stimulation mode includes: the frequency of the stimulation electrode is the same, the absolute value of the initial phase of the current of the stimulation electrode is the same, and the sum of the current amplitude of the stimulation electrode is zero. The priority of the grouping basis is: the frequency of the stimulation electrode is the same> the absolute value of the initial phase of the current of the stimulation electrode is the same> the sum of the current amplitude of the stimulation electrode is zero. Grouping according to this priority order can further improve the calculation speed and reduce the trial and error time. Of course, in actual application, the user can also group according to this priority order when grouping, and the order of grouping can be adjusted freely.

[0056] The following is an explanation of the process of obtaining the effect simulation results under the second stimulation mode and the third stimulation mode. The second stimulation mode and the third stimulation mode both belong to the situation of multiple positive and multiple negative stimulation electrodes, so the first stimulation mode cannot be directly used for simulation acquisition. For these two complex situations, the present invention groups the stimulation electrodes multiple times during the simulation calculation to convert them into simple stimulation situations for calculation processing.

[0057] like Figure 5 As shown, in the second stimulation mode, the frequencies of all stimulation electrodes are the same, and the number of positive stimulation electrodes and the number of negative stimulation electrodes are both greater than 1. In this case, all stimulation electrodes are grouped according to whether the absolute value of the initial current phase is the same, that is, the stimulation electrodes with the same absolute value of the initial phase are grouped together. Then, the stimulation electrodes of each group are judged to determine whether the number of positive stimulation electrodes in the group is 1 or whether the number of negative stimulation electrodes is 1. If the condition is met, the stimulation electrodes of the group are obtained according to the first stimulation mode. Simulation results. If the condition is not met, the stimulation electrodes of the group are grouped according to whether the sum of the current amplitudes is zero, that is, the stimulation electrodes with a sum of zero current amplitudes are grouped together (the result of this grouping process is not unique, but it is necessary to ensure that the number of positive stimulation electrodes and the number of negative stimulation electrodes in each group are both 1), and then the stimulation electrodes in the group are obtained according to the first stimulation mode. Simulation results. Finally, the effect simulation results of each group are integrated and superimposed to obtain the final effect simulation result.

[0058] like Figure 6As shown, in the third stimulation mode, the frequencies of the stimulation electrodes are not completely the same, and the number of positive stimulation electrodes and the number of negative stimulation electrodes are both greater than 1. In this case, all stimulation electrodes are divided into a group according to whether the frequencies are the same, and then it is determined whether the number of positive stimulation electrodes in the group is 1 or the number of negative stimulation electrodes is 1. If the condition is met, the stimulation electrodes in the group are obtained according to the first stimulation mode. Simulation results. If the condition is not met, the stimulation electrodes in the group are grouped according to the same absolute value of the initial current phase, and it is determined whether the number of positive stimulation electrodes in the group is 1 or the number of negative stimulation electrodes is 1. If the condition is met, the stimulation electrodes in the group are obtained according to the first stimulation mode. Simulation results. If the condition is not met, the stimulation electrodes are grouped according to whether the sum of the current amplitudes is zero (the result of this grouping process is not unique, but it is necessary to ensure that the number of positive stimulation electrodes and the number of negative stimulation electrodes in each group are both 1), and then the stimulation electrodes in the group are obtained according to the first stimulation mode. Simulation results. Finally, the effect simulation results of each group are integrated and superimposed to obtain the final effect simulation result.

[0059] That is to say, in the second stimulation mode and the third stimulation mode, the purpose of multiple grouping is to divide the multiple positive and negative stimulation electrodes into groups containing only one positive stimulation electrode or one negative stimulation electrode, so that the simulation results can be obtained by obtaining the direct current stimulation effect and mapping and linear combination, which can greatly simplify the calculation complexity and improve the calculation efficiency.

[0060] It should be noted that in some special cases, after multiple groupings, the stimulation electrodes still fail to be grouped. Specifically, after grouping according to the sum of current amplitudes being zero, there are still multiple positive stimulation electrodes and negative stimulation electrodes that are not grouped, and the sum of the currents of the positive and negative stimulation electrodes is zero everywhere. This shows that the input stimulation parameters are reasonable, but the grouping is unsuccessful. For this special case, for stimulation electrodes that fail to be grouped, consider splitting the stimulation current on the stimulation electrode into multiple minimum current units and then grouping them according to the sum of amplitudes being zero. For example Figure 7As shown, taking five stimulation electrodes as an example, positive stimulation electrode a (current value is 0.5mA, frequency is 1.5832Hz, initial phase is 0, offset is 0), positive stimulation electrode b (current value is 0.5mA, frequency is 1.5832Hz, initial phase is 0, offset is 0), negative stimulation electrode c (current value is 0.33mA, frequency is 1.5832Hz, initial phase is 0, offset is 0), negative stimulation electrode d (current value is 0.33mA, frequency is 1.5832Hz, initial phase is 0, offset is 0), negative stimulation electrode e (current value is 0.34mA, frequency is 1.5832Hz, initial phase is 0, offset is 0), these five stimulation electrodes have the same frequency and the same absolute value of initial phase, so they will be grouped into the same group. Grouping according to the sum of current amplitude is zero, these five stimulation electrodes cannot be grouped successfully. Since the minimum precision of the current values ​​of the five stimulation electrodes is 0.01, the currents of the five stimulation electrodes are divided according to the minimum current unit 0.01 and then grouped according to the sum of the current amplitudes being zero.

[0061] For example, the simulation system also includes a prompt module. When the processor determines that the current amplitude and the stimulation mode are not zero, it prompts that the stimulation electrode parameters are incorrect. In other words, if there are still unsuccessful grouping of stimulation electrodes after splitting according to the minimum current unit, it is considered that the input stimulation electrode parameters are incorrect, and the prompt module prompts. The prompt method can be a text display prompt, a voice sound prompt, etc.

[0062] For example, the simulation system further includes a phase correction module, which corrects the initial phase of the stimulation electrode before executing the simulation so that the initial phase falls within the interval [0,180). For example, the correction method is to reverse the positive and negative of the current with an initial phase ≥ 180 so that the initial phase falls within the interval [0,180). Figure 8 As shown, curve 1 represents the positive stimulation current, and the input parameters may be "amplitude = 1, frequency = 1.5832, initial phase = 0, offset = 0", or "amplitude = -1, frequency = 1.5832, initial phase = 180, offset = 0". After correcting the initial phase, the input parameters of the same current are guaranteed to be unique, which is convenient for the subsequent calculation of the effect simulation results.

[0063] In addition, this simulation system can also display the tACS effect simulation results in the form of videos, gif animations, etc., and users can manually specify which moments need to be displayed. For example, a 3D brain model that can be dragged and rotated by the mouse is presented to the user on the result display interface, and the color on it represents the electric field strength simulated here. Compared with the simulation of the effect of direct current stimulation, the present invention can display the time dimension, add a timeline under the 3D brain model, and the user selects the moment to be displayed on the timeline, and then the simulation results of the 3D brain model are automatically refreshed.

[0064] Compared with the traditional method that requires real-time calculation of the effect simulation results at each moment, this solution only needs to calculate the maximum absolute amplitude of the stimulation current and then perform overall mapping, which can significantly reduce the amount of calculation and calculation time, and is conducive to the realization of dynamic result display.

[0065] The present invention also provides a simulation method for determining the effect of transcranial alternating current stimulation, using the above-mentioned simulation system, and the simulation method includes: selecting a stimulation electrode mode for performing alternating current stimulation simulation through a human-computer interaction operation interface, the sum of the current amplitudes of the electrodes in the stimulation electrode mode is zero, including a first stimulation mode; the first stimulation mode is configured so that the number of positive stimulation electrodes or negative stimulation electrodes is 1; extracting the amplitude of the stimulation current of the first stimulation mode at a certain moment to construct a direct current stimulation result; mapping the direct current stimulation result to a simulation result of the effect of alternating current stimulation at all times.

[0066] For the contents related to the simulation system involved in the simulation method, please refer to the description of the simulation system part, which will not be repeated here.

[0067] In summary, the simulation system and simulation method for measuring the effect of transcranial alternating current stimulation of the present invention have the following advantages:

[0068] 1. According to the stimulation electrode mode set by the user, simplify the stimulation electrode mode, obtain the DC stimulation results through classification and map the DC stimulation results to AC stimulation results, and then linearly combine the classification results to obtain the final AC stimulation simulation results to improve simulation efficiency.

[0069] 2. The present invention can cope with simple stimulation schemes (first stimulation mode), complex stimulation schemes (second stimulation mode) and time interference stimulation schemes (third stimulation mode). The simulation results for the effects of complex stimulation schemes and time interference stimulation schemes can also be quickly obtained. It not only has high simulation efficiency but also has a wide range of applications.

[0070] Based on the above ideal embodiments of the present invention, the relevant staff can make various changes and modifications without departing from the technical concept of the present invention through the above description. The technical scope of the present invention is not limited to the contents of the specification, but must be determined according to the scope of the claims.

Claims

1. A simulation system for measuring the effect of transcranial alternating current stimulation, characterized in that: include: A processor having a human-machine interactive operation interface for selecting a stimulation electrode mode for performing alternating current stimulation simulation, wherein the sum of the current amplitudes of the electrodes in the stimulation electrode mode is zero at any time, and the stimulation electrode mode includes a first stimulation mode, a second stimulation mode, and a third stimulation mode; the first stimulation mode is configured such that the number of positive stimulation electrodes or negative stimulation electrodes is 1; the second stimulation mode is configured such that the number of positive stimulation electrodes and negative stimulation electrodes is greater than 1 at the same frequency; the third stimulation mode is configured such that the number of positive stimulation electrodes and negative stimulation electrodes is greater than 1 at different frequencies; a grouping module, grouping the second stimulation pattern or the third stimulation pattern into a plurality of first stimulation patterns; A direct current construction module extracts the amplitude of the stimulation current of the first stimulation mode at a certain moment to construct a direct current stimulation result; The effect simulation module is used to map the DC stimulation result into the effect simulation result of AC stimulation at all times.

2. The simulation system according to claim 1, characterized in that: The DC building blocks include: The amplitude of the stimulation current of the first stimulation mode at a certain moment is extracted and input into the direct current stimulation simulation model to construct a direct current stimulation result; the direct current stimulation result includes the spatial distribution of the stimulation electric field intensity.

3. The simulation system according to claim 1 or 2, characterized in that: The amplitude at a certain moment is the point where the absolute amplitude of the stimulation current is maximum.

4. The simulation system according to claim 1, characterized in that: The effect simulation module comprises: According to the current amplitude ratio of the AC stimulation, the DC stimulation result is mapped to other moments to obtain the effect simulation result of the stimulation mode at all times; the effect simulation result includes the spatial distribution of the stimulation electric field intensity at all times.

5. The simulation system according to claim 1, characterized in that: The basis for grouping the second stimulation mode includes: the absolute values ​​of the initial phases of the currents of the stimulation electrodes are the same, and the sum of the current amplitudes of the stimulation electrodes is zero; The basis for grouping the third stimulation mode includes: the frequencies of the stimulation electrodes are the same, the absolute values ​​of the initial phases of the currents of the stimulation electrodes are the same, and the sum of the current amplitudes of the stimulation electrodes is zero.

6. The simulation system according to claim 5, characterized in that: The priority of the grouping is: the frequencies of the stimulation electrodes are the same>the absolute values ​​of the initial phases of the currents of the stimulation electrodes are the same>the sum of the current amplitudes of the stimulation electrodes is zero.

7. The simulation system according to claim 5, characterized in that: For stimulation electrodes that are not successfully grouped, the stimulation current on the stimulation electrodes is divided into a plurality of minimum current units and then grouped according to the sum of the amplitudes being zero.

8. The simulation system according to claim 1, characterized in that: Also includes: Integration modules; When the selected stimulation electrode mode is the second stimulation mode or the third stimulation mode, the effect simulation results of each stimulation mode are superimposed.

9. The simulation system according to claim 1, characterized in that: Also includes: Prompt module; When the processor determines that there is a current amplitude and a stimulation pattern that is not zero, it indicates that the stimulation electrode parameters are incorrect.

10. The simulation system according to claim 1, characterized in that: Also includes: Phase correction module; The phase correction module corrects the initial phase of the stimulation electrode before executing the simulation so that the initial phase falls within the interval [0,180).

11. A simulation method for determining the effect of transcranial alternating current stimulation, characterized in that: Using the simulation system according to any one of claims 1 to 10, the method comprises: Selecting a stimulation electrode mode for performing alternating current stimulation simulation through a human-computer interaction operation interface, wherein the sum of the current amplitudes of the electrodes in the stimulation electrode mode is zero, including a first stimulation mode; wherein the first stimulation mode is configured such that the number of positive stimulation electrodes or negative stimulation electrodes is 1; Extracting the amplitude of the stimulation current of the first stimulation mode at a certain moment to construct a direct current stimulation result; The direct current stimulation result is mapped to the effect simulation result of the alternating current stimulation at all times.

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