A method for preparing Corydalis yanhusuo and Jindanfuyan granules

Abstract

The invention provides a method for preparing Corydalis yanhusuo and Jindanfuyan granules. The method comprises the following steps: washing, removing impurities, slicing and screening Corydalis yanhusuo raw materials to obtain Corydalis yanhusuo with a preset particle size; drying the Corydalis yanhusuo, mixing it with glutinous rice, heating and frying it, and separating it; mixing the fried Corydalis yanhusuo with rice wine and salt water, and then fully stirring it, and finally performing a steaming treatment; drying the surface, and then mixing it with the glutinous rice separated in step 2, heating and frying it to dryness, and then cooling it at room temperature; screening it to obtain Corydalis yanhusuo; mixing the Corydalis yanhusuo with unused glutinous rice and storing it, screening the Corydalis yanhusuo when it is needed, and reusing the remaining glutinous rice after screening. Specifically, by optimizing the preparation process, the effective components of Corydalis yanhusuo can be better extracted and utilized, thereby further enhancing its blood circulation, analgesic and sedative effects.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a method for preparing Corydalis yanhusuo and Jindanfuyan granules. Background Art

[0002] Yanhusuo is the dried tuber of the poppy family plant Yanhusuo. It is pungent, bitter, warm in nature and enters the liver and spleen meridians. Yanhusuo has many functions, mainly including promoting blood circulation, promoting qi, and relieving pain. In addition, Yanhusuo can also be used in combination with other drugs to enhance the efficacy.

[0003] Corydalis yanhusuo is usually processed to enhance its efficacy, especially its analgesic effect, and make its active ingredients easier to decoct. However, the current processing method causes severe solidification, which makes it impossible to further extract the active ingredients in Corydalis yanhusuo, resulting in mediocre efficacy. Summary of the invention

[0004] Based on this, the embodiments of the present invention provide a method for preparing Corydalis yanhusuo and Jindan Fuyan granules, which aim to further extract the effective ingredients in Corydalis yanhusuo and improve the efficacy.

[0005] A first aspect of an embodiment of the present invention provides a method for preparing Corydalis yanhusuo, comprising the following steps:

[0006] Step 1, washing, removing impurities, slicing and sieving the raw material of Corydalis yanhusuo to obtain Corydalis yanhusuo of a preset particle size;

[0007] Step 2, drying the Corydalis yanhusuo of a preset particle size, mixing it with glutinous rice, heating and frying it, and separating the glutinous rice after frying;

[0008] Step 3, mixing the fried Corydalis yanhusuo with rice wine and salt water, then stirring them fully, and finally performing a soaking treatment;

[0009] Step 4, drying the surface of the steamed Corydalis yanhusuo, mixing it with the glutinous rice separated in step 2, heating and frying it until dry, and then cooling it at room temperature;

[0010] Step 5, sieving the cooled mixture of Corydalis yanhusuo and glutinous rice to obtain Corydalis yanhusuo;

[0011] Step 6, storing the Corydalis yanhusuo mixed with unused glutinous rice, and screening out the Corydalis yanhusuo when it is needed, and putting the remaining glutinous rice into step 2 for use;

[0012] Wherein, the heating temperature in step 2 is lower than the heating temperature in step 4.

[0013] Furthermore, the preset particle size is 8 mesh to 14 mesh.

[0014] Furthermore, in the step of drying the Corydalis yanhusuo of preset particle size, mixing it with glutinous rice, heating and frying it, and separating the glutinous rice after frying, the mass ratio of Corydalis yanhusuo to glutinous rice is 1:0.2~0.4.

[0015] Furthermore, in the step of drying the Corydalis yanhusuo of preset particle size, mixing it with glutinous rice, and heating and frying it, and separating the glutinous rice after frying, the heating and frying temperature is 80°C to 100°C at the contact surface between the frying container and the fried product, and the frying time is 10min to 15min.

[0016] Furthermore, in the step of mixing the fried Corydalis yanhusuo with rice wine and salt water, then stirring sufficiently, and finally performing a steaming treatment, the mass ratio of Corydalis yanhusuo, rice wine and salt water is 1:0.15~0.2:0.02~0.1.

[0017] Furthermore, in the step of mixing the fried Corydalis yanhusuo with rice wine and salt water, then stirring sufficiently, and finally performing a steaming treatment, the steaming temperature is 40° C. to 50° C., and the steaming time is 10 h to 20 h.

[0018] Furthermore, the surface of the steamed Corydalis is dried, then mixed with the glutinous rice separated in step 2, and heated and fried until dry, and then cooled at room temperature. The temperature of the heating and frying is 100°C to 120°C for the contact surface between the frying container and the fried product.

[0019] Furthermore, in the step of mixing and storing Corydalis yanhusuo and unused glutinous rice, the mass ratio of Corydalis yanhusuo to unused glutinous rice is 1:1.5-2.

[0020] A second aspect of the embodiments of the present invention provides a Jindan Fuyan granule, which comprises the following raw materials in parts by weight: 220 to 300 parts of peony bark, 240 to 280 parts of honeysuckle, 200 to 240 parts of red peony root, 150 to 200 parts of curcuma, 180 to 230 parts of patrinia herb, 170 to 230 parts of safflower seed, 120 to 200 parts of peach kernel, 140 to 180 parts of angelica sinensis, 130 to 190 parts of myrrh, 150 to 180 parts of cassia twig, 140 to 180 parts of cyperus rotundus, and 200 to 300 parts of coix seed, and also comprises 160 to 240 parts of Corydalis yanhusuo prepared by the Corydalis yanhusuo preparation method described in the first aspect of the embodiments of the present invention.

[0021] Compared with the prior art, the present invention has the following beneficial effects:

[0022] According to step 1, the raw material of Corydalis yanhusuo is washed, impurities are removed, sliced ​​and sieved to obtain Corydalis yanhusuo of preset particle size; step 2, the Corydalis yanhusuo of preset particle size is dried, mixed with glutinous rice, heated and fried, and the glutinous rice is separated after frying; step 3, the fried Corydalis yanhusuo is mixed with rice wine and salt water, and then fully stirred, and finally steamed; step 4, the surface of the steamed Corydalis yanhusuo is dried, and then mixed with the glutinous rice separated in step 2, heated and fried to dry, and then cooled at room temperature; step 5, the cooled mixture of Corydalis yanhusuo and glutinous rice is sieved to obtain Corydalis yanhusuo; step 6, Corydalis yanhusuo is mixed with unused glutinous rice and stored, and when Corydalis yanhusuo is needed, Corydalis yanhusuo is sieved out, and the remaining glutinous rice after sieving is put into step 2 for use; wherein the heating temperature in step 2 is lower than the heating temperature in step 4. Specifically, by optimizing the preparation process, the effective ingredients of Corydalis yanhusuo can be better extracted and utilized, thereby further enhancing its blood circulation, analgesic and sedative effects. DETAILED DESCRIPTION

[0023] It should be noted that when an element is referred to as being "fixed to" another element, it may be directly on the other element or there may be a central element. When an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be a central element at the same time. The terms "vertical", "horizontal", "left", "right" and similar expressions used herein are for illustrative purposes only.

[0024] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art to which the present invention belongs. The terms used herein in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention. The term "and / or" used herein includes any and all combinations of one or more of the related listed items.

[0025] The present invention provides a method for preparing Corydalis yanhusuo, which specifically comprises the following steps:

[0026] Step 1: Wash, remove impurities, slice and sieve the raw material of Corydalis yanhusuo to obtain Corydalis yanhusuo of preset particle size.

[0027] Specifically, first, select high-quality raw Corydalis yanhusuo medicinal materials, ensure that there are no impurities and mildew, put the raw Corydalis yanhusuo medicinal materials into clean water, gently scrub and remove the dirt and impurities on the surface. Put the cleaned Corydalis yanhusuo medicinal materials into a medicine moistening machine or soak them in clean water to make them fully absorb water and moisten them for easy slicing. Put the moistened Corydalis yanhusuo medicinal materials into a medicine cutting machine, and finally get 8-14 mesh Corydalis yanhusuo.

[0028] Step 2: Dry the Corydalis yanhusuo with a preset particle size, mix it with glutinous rice, heat and fry it, and separate the glutinous rice after frying.

[0029] It should be noted that the Corydalis yanhusuo particles are placed in a ventilated and dry place to be fully dried until no moisture remains. Then, clean, impurity-free glutinous rice is selected, mixed with the glutinous rice, and stirred evenly. The mass ratio of Corydalis yanhusuo to glutinous rice is 1:0.2~0.4. Exemplarily, the mass ratio of Corydalis yanhusuo to glutinous rice is 1:0.2, 1:0.3 or 1:0.4, etc., but not limited to this. Specifically, during the heating and frying process, the heating and frying temperature is 80℃~100℃ at the contact surface between the frying container and the fried product, and the frying time is 10min~15min.

[0030] It can be understood that this method utilizes the adsorption and thermal conductivity of rice to help release and transform the effective ingredients in Corydalis yanhusuo. More specifically, by frying the rice, the Corydalis yanhusuo can be pre-dried to increase the surface roughness, and at the same time, it helps the subsequent absorption of rice wine and salt water.

[0031] Step three, mix the fried Corydalis yanhusuo with rice wine and salt water, then stir thoroughly and finally stew.

[0032] In this embodiment, the rice wine is prepared by traditional technology, including raw material preparation, cooking and cooling, saccharification and fermentation, post-fermentation and clarification, among which the main raw material used is glutinous rice. Specifically, the mass ratio of Corydalis yanhusuo, rice wine and salt water is 1:0.15~0.2:0.02~0.1, the concentration of salt water is 10%~30%, and during the process of steaming, the steaming temperature is controlled to be 40℃~50℃, and the steaming time is 10h~20h. It can be understood that both wine and salt can increase the permeability of drugs in the body, promote the efficacy of the drug, and further enhance its effect of promoting blood circulation and relieving pain.

[0033] Step 4, drying the surface of the steamed Corydalis yanhusuo, mixing it with the glutinous rice separated in step 2, frying it until dry, and then cooling it at room temperature.

[0034] It should be noted that the glutinous rice separated in step 2 is reused and fried at a higher temperature, wherein the temperature of heating and frying is 100°C to 120°C at the contact surface between the frying container and the fried product, so that the effective ingredients in Corydalis yanhusuo are easier to dissolve, thereby improving its bioavailability and efficacy. In addition, frying the rice can reduce its toxicity, making it safer for clinical use.

[0035] Step 5, sieve the cooled mixture of Corydalis yanhusuo and glutinous rice to obtain Corydalis yanhusuo.

[0036] Step six, mix and store the Corydalis yanhusuo with unused glutinous rice. When the Corydalis yanhusuo is needed, sieve it out and put the remaining glutinous rice after sieving into step two for use.

[0037] Specifically, in order to ensure the drying of Corydalis yanhusuo, Corydalis yanhusuo is mixed with unused glutinous rice and stored, wherein the mass ratio of Corydalis yanhusuo to unused glutinous rice is 1:1.5-2, and exemplary, the mass ratio of Corydalis yanhusuo to unused glutinous rice is 1:1.5, 1:1.6, 1:1.7, 1:1.8, 1:1.9 or 1:2, etc., but not limited thereto. In addition, Corydalis yanhusuo is screened out, and the remaining glutinous rice after screening is put into step 2 for utilization, so that the glutinous rice is fully utilized in the whole process.

[0038] Example 1

[0039] Embodiment 1 of the present invention provides a method for preparing Corydalis yanhusuo, which specifically comprises the following steps:

[0040] Step 1: Slice and sieve the raw material of Corydalis yanhusuo to obtain 10-mesh Corydalis yanhusuo.

[0041] Step 2: Dry the Corydalis yanhusuo of preset particle size, mix it with glutinous rice, and heat and fry it. After frying, separate the glutinous rice. The mass ratio of Corydalis yanhusuo to glutinous rice is 1:0.2. The temperature of heating and frying is controlled to be 80°C at the contact surface of the frying container and the fried product, and the frying time is 10 minutes.

[0042] Step three, mix the fried Corydalis yanhusuo with rice wine and salt water, then stir thoroughly, and finally perform steaming treatment, wherein the mass ratio of Corydalis yanhusuo, rice wine and salt water is 1:0.15:0.02, the steaming temperature is controlled at 40°C, and the steaming time is 10 hours.

[0043] Step 4, drying the surface of the steamed Corydalis yanhusuo, mixing it with the glutinous rice separated in step 2, frying it with heat, and then cooling it at room temperature, wherein the temperature of heating and frying is controlled to be 100°C at the contact surface between the frying container and the fried product.

[0044] Step 5, sieve the cooled mixture of Corydalis yanhusuo and glutinous rice to obtain Corydalis yanhusuo.

[0045] Step six, mix and store Corydalis yanhusuo and unused glutinous rice. When Corydalis yanhusuo is needed, screen it out and put the remaining glutinous rice into step two for use, wherein the mass ratio of Corydalis yanhusuo to unused glutinous rice is 1:1.5.

[0046] Example 2

[0047] On the basis of Example 1, this Example 2 also provides a method for preparing Corydalis yanhusuo, which differs from the method for preparing Corydalis yanhusuo provided in this Example 1 in that, in step 1, the Corydalis yanhusuo raw material is sliced ​​and sieved to obtain 8-mesh Corydalis yanhusuo.

[0048] Example 3

[0049] On the basis of Example 1, this Example 3 also provides a method for preparing Corydalis yanhusuo, which differs from the method for preparing Corydalis yanhusuo provided in this Example 1 in that, in step 1, the Corydalis yanhusuo raw material is sliced ​​and sieved to obtain 12-mesh Corydalis yanhusuo.

[0050] Example 4

[0051] On the basis of Example 1, this Example 4 also provides a method for preparing Corydalis yanhusuo, which differs from the method for preparing Corydalis yanhusuo provided in this Example 1 in that, in step 1, the Corydalis yanhusuo raw material is sliced ​​and sieved to obtain 14-mesh Corydalis yanhusuo.

[0052] Example 5

[0053] On the basis of Example 1, this Example 5 also provides a method for preparing Corydalis yanhusuo, which differs from the method for preparing Corydalis yanhusuo provided in this Example 1 in that, in step 2, the mass ratio of Corydalis yanhusuo to glutinous rice is 1:0.3.

[0054] Example 6

[0055] On the basis of Example 1, this Example 6 also provides a method for preparing Corydalis yanhusuo, which differs from the method for preparing Corydalis yanhusuo provided in this Example 1 in that, in step 2, the mass ratio of Corydalis yanhusuo to glutinous rice is 1:0.4.

[0056] Example 7

[0057] On the basis of Example 1, this Example 7 also provides a method for preparing Corydalis yanhusuo, which differs from the method for preparing Corydalis yanhusuo provided in this Example 1 in that in step 2, the heating and frying temperature is 90°C.

[0058] Example 8

[0059] On the basis of Example 1, this Example 8 also provides a method for preparing Corydalis yanhusuo, which differs from the method for preparing Corydalis yanhusuo provided in this Example 1 in that in step 2, the temperature for heating and frying is 100°C; in step 4, the temperature for heating and frying until dry is 110°C.

[0060] Example 9

[0061] On the basis of Example 1, Example 9 further provides a method for preparing Corydalis yanhusuo, which differs from the method for preparing Corydalis yanhusuo provided in Example 1 in that, in step 2, the frying time is 15 minutes.

[0062] Example 10

[0063] On the basis of Example 1, this Example 10 also provides a method for preparing Corydalis yanhusuo, which differs from the method for preparing Corydalis yanhusuo provided in this Example 1 in that the mass ratio of Corydalis yanhusuo, rice wine and brine is 1: 0.2: 0.1.

[0064] Embodiment 11

[0065] On the basis of Example 1, this Example 11 also provides a method for preparing Corydalis yanhusuo, which differs from the method for preparing Corydalis yanhusuo provided in this Example 1 in that in step three, the moistening temperature is controlled to be 45°C.

[0066] Example 12

[0067] On the basis of Example 1, this Example 12 also provides a method for preparing Corydalis yanhusuo, which differs from the method for preparing Corydalis yanhusuo provided in this Example 1 in that, in step three, the moistening temperature is controlled to be 50°C.

[0068] Embodiment 13

[0069] On the basis of Example 1, this Example 13 also provides a method for preparing Corydalis yanhusuo, which differs from the method for preparing Corydalis yanhusuo provided in this Example 1 in that, in step three, the steaming time is controlled to be 15 hours.

[0070] Embodiment 14

[0071] On the basis of Example 1, this Example 14 also provides a method for preparing Corydalis yanhusuo, which differs from the method for preparing Corydalis yanhusuo provided in this Example 1 in that, in step three, the steaming time is controlled to be 20 hours.

[0072] Embodiment 15

[0073] On the basis of Example 1, this Example 15 also provides a method for preparing Corydalis yanhusuo, which differs from the method for preparing Corydalis yanhusuo provided in this Example 1 in that, in step 4, the temperature for heating and frying to dryness is controlled to be 110°C.

[0074] Example 16

[0075] On the basis of Example 1, this Example 16 also provides a method for preparing Corydalis yanhusuo, which differs from the method for preparing Corydalis yanhusuo provided in this Example 1 in that, in step 4, the temperature for heating and frying to dryness is controlled to be 120°C.

[0076] Comparative Example 1

[0077] The difference between this comparative example 1 and embodiment 1 is that the process of mixing with glutinous rice and heating and frying in step 2, and separating the glutinous rice after frying is cancelled, and the Corydalis yanhusuo in step 1 is directly put into the process of step 3.

[0078] Comparative Example 2

[0079] The difference between this comparative example 2 and example 1 is that the process of heating and frying to dryness in step 4 is eliminated.

[0080] Comparative Example 3

[0081] The difference between this comparative example 3 and embodiment 1 is that the process of mixing with glutinous rice and frying in step 2 and step 4 is eliminated.

[0082] Prior art

[0083] Take 10-mesh Corydalis yanhusuo, place it in a ventilated oven and bake it at 80℃ until it turns dark yellow, then heat it to 100℃ and heat it for 10 minutes. Take it out and immediately mix it with 20% vinegar while it is hot, simmer it for 4 hours, and then dry it at 70℃.

[0084] The total alkaloid contents of the Corydalis yanhusuo prepared according to Examples 1 to 16, Comparative Examples 1 to 3 and the process in the prior art were determined by high performance liquid chromatography. The results are shown in Table 1 below.

[0085] Table 1

[0086]

[0087] The data show that according to Examples 1 to 4, a smaller particle size can increase the total alkaloid content to a certain extent; according to Examples 1, 5 and 6, when the amount of glutinous rice added is large, the total alkaloid content can be increased to a certain extent; according to Examples 1, 7 and 8, when the temperature of heating and frying is controlled to be high, the total alkaloid content can be increased to a certain extent; according to Examples 1 and 9, it can be reflected that extending the frying time can increase the total alkaloid content to a certain extent; according to Examples 1 and 10, it can be reflected that the use of rice wine and salt water to mix the processing of Corydalis yanhusuo can increase the content of total alkaloids to a certain extent. To some extent, the total alkaloid content is improved; according to Example 1, Example 11 and Example 12, it can be reflected that increasing the moistening temperature can increase the total alkaloid content to a certain extent; according to Example 1, Example 13 and Example 14, it can be reflected that extending the moistening time can increase the total alkaloid content to a certain extent; according to Example 1, Example 15 and Example 16, it can be reflected that increasing the temperature of heating and frying can increase the total alkaloid content to a certain extent; according to Comparative Examples 1 and 2, when part of the frying process is missing, the total alkaloid content is reduced to a certain extent; according to Comparative Example 3, when there is no frying process, the total alkaloid content is greatly reduced. In summary, under the complete preparation process of Corydalis yanhusuo provided by the present invention, the total alkaloid content of Corydalis yanhusuo can be significantly improved.

[0088] On the other hand, the present invention further provides a Jindan Fuyan granule, which comprises the following raw materials in parts by weight: 220 to 300 parts of peony bark, 240 to 280 parts of honeysuckle, 200 to 240 parts of red peony root, 150 to 200 parts of curcuma, 180 to 230 parts of patrinia herb, 170 to 230 parts of safflower, 120 to 200 parts of peach kernel, 140 to 180 parts of angelica sinensis, 130 to 190 parts of myrrh, 150 to 180 parts of cassia twig, 140 to 180 parts of cyperus rotundus, 200 to 300 parts of coix seed, and also comprises 160 to 240 parts of the above-mentioned Corydalis yanhusuo.

[0089] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "examples", "specific examples", or "some examples" means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner.

[0090] The above-mentioned embodiments only express several implementation methods of the present invention, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the scope of the patent of the present invention. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, which all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. A method for preparing Corydalis yanhusuo, characterized in that: The following steps are involved: Step 1, washing, removing impurities, slicing and sieving the raw material of Corydalis yanhusuo to obtain Corydalis yanhusuo of a preset particle size, wherein the preset particle size is 8 meshes to 12 meshes; Step 2, drying the Corydalis yanhusuo of preset particle size, mixing it with glutinous rice, and heating and frying it, and separating the glutinous rice after frying, wherein the temperature of the heating and frying is 80° C. to 100° C. for the contact surface between the frying container and the fried product, the frying time is 10 min to 15 min, and the mass ratio of Corydalis yanhusuo to glutinous rice is 1:0.2 to 0.4; Step 3, mixing the fried Corydalis yanhusuo with rice wine and salt water, then fully stirring, and finally performing a steaming treatment, the mass ratio of Corydalis yanhusuo, rice wine and salt water is 1:0.15~0.2:0.02~0.1, the concentration of salt water is 10%~30%, the steaming temperature is 40℃~50℃, and the steaming time is 10h~20h; Step 4, drying the surface of the steamed Corydalis yanhusuo, mixing it with the glutinous rice separated in step 2, heating and frying it until dry, and then cooling it at room temperature, wherein the temperature of the heating and frying is 100° C. to 120° C. for the contact surface between the frying container and the frying product; Step 5, sieving the cooled mixture of Corydalis yanhusuo and glutinous rice to obtain Corydalis yanhusuo; Step 6, storing the mixed corydalis yanhusuo and unused glutinous rice, screening the corydalis yanhusuo when it is needed, and putting the remaining glutinous rice into step 2 for use, wherein the mass ratio of corydalis yanhusuo to unused glutinous rice is 1:1.5-2; Wherein, the heating temperature in step 2 is lower than the heating temperature in step 4.

2. A Jindan Fuyan granule, comprising the following raw materials in parts by weight: 220 to 300 parts of peony bark, 240 to 280 parts of honeysuckle, 200 to 240 parts of red peony root, 150 to 200 parts of curcuma, 180 to 230 parts of patrinia herb, 170 to 230 parts of safflower, 120 to 200 parts of peach kernel, 140 to 180 parts of angelica, 130 to 190 parts of myrrh, 150 to 180 parts of cassia twig, 140 to 180 parts of cyperus, and 200 to 300 parts of coix seed, characterized in that: It also includes preparing 160 to 240 parts of Corydalis yanhusuo by the Corydalis yanhusuo preparation method according to claim 1.

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