Nitric oxide preparation device and use method thereof

Abstract

The invention discloses a nitric oxide preparation device and a method for using the same, and belongs to the technical field of nitric oxide preparation. A plurality of one-way valves are arranged on the inner top ring, and the electric shock chamber is connected to the mixing chamber in one direction through the one-way valve; a symmetrical swing groove is provided on the inner wall of the electric shock chamber, and a driven connecting rod is movably arranged between the swing blocks, and a plurality of groups of mutually cooperating positive electrodes and negative electrodes are arranged on the driven connecting rod; a driving gear is installed at the output end of the motor, and a plurality of groups of linkage gears meshing with the driving gear are also installed at the bottom of the top cover, and a plurality of groups of nozzles are arranged at the bottom of the linkage gear; a gear ring meshing with the linkage gear is also rotatably arranged on the inner wall of the bottom of the top cover. The present invention can fully mix oxygen and nitrogen through the mixing chamber, and enter the electric shock chamber through the one-way valve. The current generated between the positive electrode and the negative electrode will electrocute the mixed gas, and the ferric chloride absorbent is sprayed into the electric shock chamber through the nozzle to fully absorb the nitric oxide. The design improves work efficiency and effect.

Description

Technical Field

[0001] The present invention relates to the technical field of nitric oxide preparation, in particular to a nitric oxide preparation device and a use method thereof. Background Art

[0002] Studies have shown that nitric oxide is an endothelial-derived relaxing factor (EDRF), which plays an important role in regulating vascular tension and maintaining a relatively relaxed state of blood vessels. The working principle is that nitric oxide molecules activate guanylate cyclase in smooth muscle cells, increasing the amount of cyclic guanosine monophosphate (cGMP) generated from intracellular guanosine triphosphate (GTP). cGMP can reduce the concentration of Ca2+ ions in vascular smooth muscle, causing vascular smooth muscle relaxation and achieving the effect of vasodilation. At the same time, nitric oxide also has the function of dilating bronchi, improving blood perfusion ratio and thus increasing oxygen saturation, as well as certain anti-inflammatory, anti-thrombotic and anti-infective functions. It is the first confirmed gas information molecule in the human body and has important physiological functions.

[0003] A healthy human body produces nitric oxide. If the normal endothelial cells lose their ability to produce nitric oxide, it may cause pulmonary artery contraction and smooth muscle cell hyperplasia. The level of nitric oxide synthase decreases in patients with primary pulmonary hypertension, indicating that insufficient local nitric oxide production may be part of the disease process. It is also found that the more severe the changes in the pulmonary vessels, the less nitric oxide synthase. Inhaled nitric oxide can selectively dilate the pulmonary blood vessels and reduce pulmonary artery pressure (due to the short metabolism time of nitric oxide (2-6s), it will not affect the systemic blood circulation, but continuous inhalation is required to ensure the therapeutic effect). Inhaled nitric oxide has been used as one of the important methods for treating pulmonary hypertension in the clinic. At present, nitric oxide inhalation therapy has been widely used in persistent pulmonary hypertension of the newborn (PPHN), adult pulmonary hypertension and respiratory failure caused by various reasons. There are clear and standardized treatment methods and related equipment in the clinic, so there is an urgent need for medical nitric oxide gas with stable concentration, high purity and high cleanliness that can be provided to patients.

[0004] The patent application with publication number CN117772093A discloses a discharge reactor for preparing nitric oxide gas. The reactor is mainly composed of a reactor cylinder, a discharge electrode and a grounding electrode, a central rotating shaft and a transmission motor, a gas stirring blade, a discharge conductive rod, a slurry stirring paddle and related pipeline components. The preparation method is to introduce the reaction gas into the reactor, connect the discharge electrode to a high-voltage power supply, and rotate the discharge conductive rod driven by the transmission motor. When the discharge conductive rod moves to the point where the spatial distance between its two long ends and the fixed electrode pair is the minimum, the gas in the space between the electrode pair port and the discharge conductive rod is punctured and ionized to form a spark or arc discharge, and the nitrogen and oxygen in the gas react chemically to generate nitric oxide gas, which is then absorbed by the absorbent slurry in the lower part of the reactor. The absorbent after absorption saturation is desorbed and regenerated.

[0005] However, the processing efficiency of the nitric oxide gas reactor disclosed above is average, the degree of freedom of the discharge electrode is poor, and oxygen and nitrogen cannot be pre-mixed. After the preparation, the absorption effect of nitric oxide is average. Summary of the invention

[0006] The purpose of the present invention is to provide a nitric oxide preparation device and a method for using the same in order to solve the problems of the existing nitric oxide gas reactor having average processing efficiency, poor freedom of the discharge electrode, inability to premix oxygen and nitrogen, and average absorption effect of nitric oxide after preparation.

[0007] To achieve the above-mentioned purpose, the technical solution of the present invention is: a nitric oxide preparation device, comprising a spherical electric shock chamber and a mixing chamber, the electric shock chamber and the mixing chamber are coaxially arranged, and the mixing chamber is arranged on the outside of the electric shock chamber; an inner top ring is arranged at the top opening of the electric shock chamber, an outer top ring is arranged at the top opening of the mixing chamber, and a top cover matching the outer top ring is arranged on the top of the mixing chamber; a plurality of groups of one-way valves are arranged on the inner top ring, and the electric shock chamber is unidirectionally connected with the mixing chamber through the one-way valve; a symmetrical swing groove is opened on the inner wall of the electric shock chamber, a swing block is movably arranged in the swing groove, and the swing block A driven connecting rod is movably arranged between the top cover and the driven connecting rod is provided with a plurality of groups of anode electrodes and cathode electrodes cooperating with each other. The anode electrodes and cathode electrodes reciprocate and swing relative to the swinging groove while they themselves also reciprocate and intermittently rotate relative to the swinging block; a motor is installed in the middle of the top cover, a driving gear is installed at the output end of the motor, and a plurality of groups of linkage gears meshing with the driving gear are also installed at the bottom of the top cover, and a plurality of groups of nozzles are arranged at the bottom of the linkage gear; a gear ring meshing with the linkage gear is also rotatably arranged on the inner wall of the bottom of the top cover, and the bottom of the gear ring abuts against the top of the inner top ring and seals the electric shock chamber.

[0008] As a further solution of the present invention: a first air inlet pipe and a second air inlet pipe are arranged on the outer wall of the mixing bin.

[0009] As a further solution of the present invention: a storage box cooperating with the nozzle is arranged on the top cover, a sensor is arranged at the bottom of the electric shock chamber, a drain pipe is also arranged at the bottom of the electric shock chamber, and a drain valve is arranged on the drain pipe.

[0010] As a further solution of the present invention: a swing column is arranged in the middle of the bottom of the electric shock chamber, a lower bent plate is movably arranged on the swing column, an upper bent plate cooperating with the lower bent plate is arranged at the bottom of the output end of the motor, an active connecting rod is fixedly arranged between the upper bent plate and the lower bent plate, and a shaft sleeve cooperating with the driven connecting rod is arranged in the middle of the active connecting rod.

[0011] As a further solution of the present invention: an upper T-shaped groove is provided on the inner wall of the top cover, and an upper T-shaped rail matching therewith is provided on the top of the gear ring; a lower T-shaped groove is provided on the top of the inner top ring, and a lower T-shaped rail matching therewith is provided on the bottom of the gear ring.

[0012] As a further solution of the present invention: a plurality of scrapers and stirring shafts are provided at the bottom of the gear ring, wherein the scrapers are used to scrape the inner wall of the electric shock chamber, and the stirring shaft is located between the electric shock chamber and the mixing chamber and stirs and mixes the oxygen and nitrogen.

[0013] As a further solution of the present invention: bearings are further provided on both sides of the driven connecting rod, and the driven connecting rod is movably connected to the swing block through the bearings.

[0014] As a further solution of the present invention: a plurality of supporting legs are provided at the bottom of the mixing bin, a control panel is also provided on the outer wall of the mixing bin, and a plurality of observation windows are installed on the outer wall of the mixing bin.

[0015] As a further solution of the present invention: the top cover is provided with an electrical device that cooperates with the anode electrode and the cathode electrode.

[0016] As a further scheme of the present invention: a method for using the nitric oxide preparation equipment, S1. injecting oxygen and nitrogen into the mixing chamber respectively, and the mixed gas enters the electric shock chamber through a one-way valve; S2. starting the positive electrode and the negative electrode, and fully energizing and shocking the mixed gas in the electric shock chamber through the cooperation of the swing block and the driven connecting rod; S3. spraying ferric chloride absorbent into the electric shock chamber through a nozzle to absorb the generated nitric oxide.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] The present invention can fully mix oxygen and nitrogen for pretreatment through the design of the mixing chamber, and enter the electric shock chamber through a one-way valve. During operation, the current generated between the anode electrode and the cathode electrode will electrocute the mixed gas, and under the drive of the active connecting rod, the anode electrode and the cathode electrode reciprocate relative to the swing groove while they themselves reciprocate and intermittently rotate relative to the swing block, which can further improve the electric shock effect and avoid dead angles. Ferric chloride absorbent is sprayed into the electric shock chamber through a nozzle to fully absorb the generated nitric oxide and carry out the next process. This design further improves the working efficiency and effect of the nitric oxide preparation equipment. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] The present invention will be further explained below in conjunction with the accompanying drawings and embodiments:

[0020] Figure 1 It is a three-dimensional structural diagram of the present invention;

[0021] Figure 2 is a cross-sectional view of the electric shock chamber of the present invention;

[0022] Figure 3 The internal structure of the present invention Figure 1 ;

[0023] Figure 4 The internal structure of the present invention Figure 2 ;

[0024] Figure 5 is a cross-sectional view of the present invention;

[0025] Figure 6 yes Figure 5 A magnified view of the structure at center.

[0026] Description of reference numerals:

[0027] 1. Electric shock chamber; 2. Mixing chamber; 3. Top cover; 4. Support legs; 5. Control panel; 6. First air inlet pipe; 7. Second air inlet pipe; 8. Sensor; 9. Drain pipe; 10. Drain valve; 11. Observation window; 12. Inner top ring; 13. Outer top ring; 14. One-way valve; 15. Swing groove; 16. Swing block; 17. Driven connecting rod; 18. Anode; 19. Cathode; 20. Bearing; 21. Swing column; 22. Lower bend plate; 23. Motor; 24. Upper bend plate; 25. Active connecting rod; 26. Bushing; 27. Active gear; 28. Linkage gear; 29. ​​Nozzle; 30. Gear ring; 31. Upper T-slot; 32. Lower T-slot; 33. Upper T-rail; 34. Lower T-rail; 35. Scraper; 36. Agitator shaft; 37. Electrical equipment; 38. Storage box. DETAILED DESCRIPTION

[0028] The following will be combined with the attached Figures 1 to 6The technical solution of the present invention is described clearly and completely. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0029] The present invention provides a preparation device for nitric oxide by improving the nitric oxide preparation device, such as Figure 1-Figure 6 As shown, it includes an electric shock chamber 1 and a mixing chamber 2, the electric shock chamber 1 and the mixing chamber 2 are coaxially arranged, and the mixing chamber 2 is arranged on the outside of the electric shock chamber 1; an inner top ring 12 is arranged at the top opening of the electric shock chamber 1, an outer top ring 13 is arranged at the top opening of the mixing chamber 2, and a top cover 3 matched with the outer top ring 13 is arranged on the top of the mixing chamber 2; multiple groups of one-way valves 14 are arranged on the inner top ring 12, and the electric shock chamber 1 is connected with the mixing chamber 2 in one direction through the one-way valves 14; symmetrical swing grooves 15 are opened on the inner wall of the electric shock chamber 1, and swing blocks 16 are movably arranged in the swing grooves 15, and driven connecting rods 17 are movably arranged between the swing blocks 16, and the driven connecting rods 17 A plurality of groups of mutually cooperating anode electrodes 18 and cathode electrodes 19 are arranged on the top cover 3. While the anode electrodes 18 and cathode electrodes 19 reciprocate relative to the swing groove 15, they also reciprocate and intermittently rotate relative to the swing block 16. A motor 23 is installed in the middle of the top cover 3, and a driving gear 27 is installed at the output end of the motor 23. A plurality of linkage gears 28 meshing with the driving gear 27 are also installed at the bottom of the top cover 3, and a plurality of groups of nozzles 29 are arranged at the bottom of the linkage gear 28. A gear ring 30 meshing with the linkage gear 28 is also rotatably arranged on the inner wall of the bottom of the top cover 3, and the bottom of the gear ring 30 abuts against the top of the inner top ring 12 and seals the electric shock chamber 1.

[0030] In this embodiment: the nitric oxide preparation device is mainly divided into two parts: an electric shock chamber 1 and a mixing chamber 2. When the device is in use, nitrogen and oxygen are first input into the mixing chamber 2 through the first air inlet pipe 6 and the second air inlet pipe 7. Then the motor 23 and the electric device 37 are started. When the motor 23 drives the upper curved plate 24 and the active connecting rod 25 below to rotate, driven by the shaft sleeve 26, the positive electrode 18 and the negative electrode 19 reciprocate up and down relative to the swing groove 15, and they also reciprocate and intermittently rotate relative to the swing block 16, so as to fully shock the mixed gas. Ferric chloride absorbent is arranged in the storage box 38, and a driving gear 27 is also installed at the output end of the motor 23. When the driving gear 27 drives multiple groups of linkage gears 28 to rotate, multiple groups of nozzles 29 spray out ferric chloride absorbent to fully absorb the nitric oxide gas. The liquid after absorption will be stored at the bottom of the electric shock chamber 1. When the sensor 8 detects that the liquid at the bottom of the electric shock chamber 1 reaches a preset depth, the drain valve 10 is started to discharge the absorbent.

[0031] See attached Figure 1 and attached Figure 5A first air inlet pipe 6 and a second air inlet pipe 7 are arranged on the outer wall of the mixing chamber 2.

[0032] In this embodiment, in order to input nitrogen and oxygen into the mixing chamber 2 respectively, two sets of independent air inlet pipes are designed.

[0033] See attached Figure 1 -Attached Figure 2 A storage box 38 cooperating with the nozzle 29 is arranged on the top cover 3, a sensor 8 is arranged at the bottom of the electric shock chamber 1, and a drain pipe 9 is also arranged at the bottom of the electric shock chamber 1, and a drain valve 10 is arranged on the drain pipe 9.

[0034] In this embodiment, a ferric chloride absorbent is arranged in the storage tank 38, and the nitric oxide gas is fully absorbed by multiple groups of nozzles 29. When the sensor 8 detects that the liquid at the bottom of the shock chamber 1 reaches a preset depth, the drain valve 10 is activated to discharge the absorbent.

[0035] See attached Figure 3 -Attached Figure 5 A swing column 21 is provided in the middle of the bottom of the electric shock chamber 1, and a lower bent plate 22 is movably provided on the swing column 21. An upper bent plate 24 cooperating with the lower bent plate 22 is provided at the bottom of the output end of the motor 23, and an active connecting rod 25 is fixedly provided between the upper bent plate 24 and the lower bent plate 22. A shaft sleeve 26 cooperating with the driven connecting rod 17 is provided in the middle of the active connecting rod 25; bearings 20 are also provided on both sides of the driven connecting rod 17, and the driven connecting rod 17 is movably connected to the swing block 16 through the bearings 20.

[0036] In this embodiment, a bearing 20 is provided to ensure that the swing block 16 is movably connected to the driven connecting rod 17 so that the driven connecting rod 17 rotates and swings. Driven by the motor 23, the active connecting rod 25 rotates and swings relative to the shock chamber 1, thereby driving the positive electrode 18 and the negative electrode 19 to swing up and down relative to the swing slot 15 through the shaft sleeve 26, and the active connecting rod 25 also rotates intermittently relative to the swing block 16.

[0037] See attached Figure 2 -Attached Figure 6 An upper T-shaped groove 31 is provided on the inner wall of the top cover 3, and an upper T-shaped rail 33 matching therewith is provided on the top of the gear ring 30; a lower T-shaped groove 32 is provided on the top of the inner top ring 12, and a lower T-shaped rail 34 matching therewith is provided on the bottom of the gear ring 30.

[0038] In this embodiment, in order to install the gear ring 30 and seal the electric shock chamber 1 and the mixing chamber 2, a track and slide groove structure is designed.

[0039] See attached Figure 4 -Attached Figure 5A plurality of scrapers 35 and a stirring shaft 36 are also provided at the bottom of the gear ring 30. The scrapers 35 are used to scrape the inner wall of the electric shock chamber 1. The stirring shaft 36 is located between the electric shock chamber 1 and the mixing chamber 2 and stirs and mixes the oxygen and nitrogen.

[0040] In this embodiment, a stirring shaft 36 is designed to improve the mixing efficiency, and a scraper 35 is designed to scrape the absorption liquid attached to the inner wall.

[0041] See attached Figure 1 A plurality of supporting legs 4 are arranged at the bottom of the mixing bin 2 , a control panel 5 is arranged on the outer wall of the mixing bin 2 , and a plurality of observation windows 11 are installed on the outer wall of the mixing bin 2 .

[0042] In this embodiment, the electric shock chamber 1 is made of transparent glass material. In order to facilitate observation of the conditions in the mixing chamber 2 and the electric shock chamber 1, an observation window 11 is designed.

[0043] See attached Figure 1 and attached Figure 3 The top cover 3 is provided with an electrical device 37 that cooperates with the anode electrode 18 and the cathode electrode 19 .

[0044] In this embodiment, an electric device 37 is designed to supply power to the electrodes and thus perform electric shock on the mixed gas.

[0045] Working principle of the present invention: When the device is in use, nitrogen and oxygen are first input into the mixing chamber 2 through the first air inlet pipe 6 and the second air inlet pipe 7. Then the motor 23 and the electric device 37 are started. When the motor 23 drives the upper curved plate 24 and the active connecting rod 25 below to rotate, driven by the shaft sleeve 26, the positive electrode 18 and the negative electrode 19 reciprocate up and down relative to the swing groove 15, and they themselves also reciprocate and intermittently rotate relative to the swing block 16, so as to fully shock the mixed gas. Ferric chloride absorbent is arranged in the storage box 38, and a driving gear 27 is also installed at the output end of the motor 23. When the driving gear 27 drives multiple sets of linkage gears 28 to rotate, multiple sets of nozzles 29 spray out ferric chloride absorbent to fully absorb the nitric oxide gas. The liquid after absorption will be stored at the bottom of the shock chamber 1. When the sensor 8 detects that the liquid at the bottom of the shock chamber 1 reaches a preset depth, the drain valve 10 is started to discharge the absorbent.

[0046] The above description of the disclosed embodiments enables those skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but will conform to the widest scope consistent with the principles and inventive features disclosed herein.

Claims

1. A nitric oxide preparation device, comprising an electric shock chamber (1) and a mixing chamber (2), characterized in that: The electric shock chamber (1) and the mixing chamber (2) are arranged coaxially, and the mixing chamber (2) is arranged outside the electric shock chamber (1); An inner top ring (12) is provided at the top opening of the electric shock chamber (1), an outer top ring (13) is provided at the top opening of the mixing chamber (2), and a top cover (3) that cooperates with the outer top ring (13) is provided at the top of the mixing chamber (2); a plurality of groups of one-way valves (14) are provided on the inner top ring (12), and the electric shock chamber (1) is in one-way communication with the mixing chamber (2) via the one-way valves (14); The inner wall of the electric shock chamber (1) is provided with symmetrical swing grooves (15), a swing block (16) is movably arranged in the swing grooves (15), a driven connecting rod (17) is movably arranged between the swing blocks (16), and a plurality of groups of mutually cooperating positive electrodes (18) and negative electrodes (19) are arranged on the driven connecting rod (17), and the positive electrodes (18) and negative electrodes (19) swing back and forth relative to the swing grooves (15) and rotate back and forth intermittently relative to the swing blocks (16); A motor (23) is installed in the middle of the top cover (3), a driving gear (27) is installed at the output end of the motor (23), a plurality of linkage gears (28) meshing with the driving gear (27) are installed at the bottom of the top cover (3), and a plurality of nozzles (29) are arranged at the bottom of the linkage gear (28); a gear ring (30) meshing with the linkage gear (28) is rotatably arranged on the inner wall of the bottom of the top cover (3), the bottom of the gear ring (30) abuts against the top of the inner top ring (12) and seals the electric shock chamber (1).

2. The nitric oxide preparation device according to claim 1, characterized in that: A first air inlet pipe (6) and a second air inlet pipe (7) are provided on the outer wall of the mixing chamber (2).

3. The nitric oxide preparation device according to claim 1, characterized in that: The top cover (3) is provided with a storage box (38) that cooperates with the nozzle (29), the bottom of the electric shock chamber (1) is provided with a sensor (8), the bottom of the electric shock chamber (1) is also provided with a drainage pipe (9), and the drainage pipe (9) is provided with a drainage valve (10).

4. The nitric oxide preparation device according to any one of claims 1 to 3, characterized in that: A swing column (21) is provided at the middle of the bottom of the electric shock chamber (1), a lower curved plate (22) is movably provided on the swing column (21), an upper curved plate (24) cooperating with the lower curved plate (22) is provided at the bottom of the output end of the motor (23), an active connecting rod (25) is fixedly provided between the upper curved plate (24) and the lower curved plate (22), and a shaft sleeve (26) cooperating with the driven connecting rod (17) is provided at the middle of the active connecting rod (25).

5. The nitric oxide production equipment according to any one of claims 1 to 3, characterized in that: An upper T-shaped groove (31) is provided on the inner wall of the top cover (3), and an upper T-shaped rail (33) matching therewith is provided on the top of the gear ring (30); a lower T-shaped groove (32) is provided on the top of the inner top ring (12), and a lower T-shaped rail (34) matching therewith is provided on the bottom of the gear ring (30).

6. The nitric oxide production equipment according to claim 1, characterized in that: A plurality of scrapers (35) and stirring shafts (36) are also provided at the bottom of the gear ring (30); the scrapers (35) are used to scrape the inner wall of the electric shock chamber (1); and the stirring shafts (36) are located between the electric shock chamber (1) and the mixing chamber (2) and stir and mix the oxygen and nitrogen.

7. The nitric oxide production device according to claim 1, characterized in that: Bearings (20) are also provided on both sides of the driven connecting rod (17), and the driven connecting rod (17) is movably connected to the swing block (16) via the bearings (20).

8. The nitric oxide production equipment according to claim 1, characterized in that: A plurality of groups of supporting legs (4) are arranged at the bottom of the mixing bin (2), a control panel (5) is also arranged on the outer wall of the mixing bin (2), and a plurality of groups of observation windows (11) are installed on the outer wall of the mixing bin (2).

9. The nitric oxide production device according to claim 1, characterized in that: The top cover (3) is provided with an electrical device (37) that cooperates with the anode electrode (18) and the cathode electrode (19).

10. A method for using the nitric oxide preparation device according to any one of claims 1 to 9, characterized in that: S1. Inject oxygen and nitrogen into the mixing chamber (2) respectively, and the mixed gas enters the electric shock chamber (1) through the one-way valve (14); S2. Start the positive electrode (18) and the negative electrode (19), and fully energize and shock the mixed gas in the shock chamber (1) through the cooperation of the swing block (16) and the driven connecting rod (17); S3. Spraying ferric chloride absorbent into the electric shock chamber (1) through the nozzle (29) to absorb the generated nitric oxide.

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