Arc detection device and method for nanosecond pulse irreversible electroporation equipment

Abstract

The present invention discloses an arc detection device and method for a nanosecond pulse irreversible electroporation device, comprising a first electrode, a second electrode, a high-voltage pulse module, a switch module, a resistor module, a high-frequency coil module, a circuit modulation module, a differential AD module and a processing chip module. The first electrode and the second electrode are electrically connected to the high-voltage pulse module, the high-frequency coil module is electrically connected to the high-voltage pulse module, the circuit modulation module is electrically connected to the high-frequency coil module, the differential AD module is electrically connected to the circuit modulation module, the processing chip module is electrically connected to the differential AD module, the processing chip module is electrically connected to the high-voltage pulse module, the switch module and the resistor module are electrically connected between the high-frequency coil module and the high-voltage pulse module, and it can be determined whether the arc is generated inside the host or the arc is generated by the electrode load part. When the arc is formed, timely feedback is given to make the ablation process safer and more effective.

Description

Technical Field

[0001] The present invention relates to the field of irreversible electroporation (IRE) treatment technology, and specifically to an arc detection device and method for nanosecond pulse irreversible electroporation equipment, which aims to achieve timely response to the high-voltage nanosecond pulse used for treatment when the load breaks down, thereby ensuring the safety and effectiveness of the treatment equipment. Background Art

[0002] IRE treatment technology is a new non-thermal ablation technology. It has been applied to the ablation treatment of tumors and atrial fibrillation. This technology has the characteristics of electric field dependence, no thermal damage and controllable range of action. IRE technology can be divided into microsecond IRE and nanosecond IRE according to its single pulse time. The threshold electric field strength required for nanosecond IRE is much higher than that of microsecond IRE, and the voltage amplitude of the output pulse of the ablation device is required to be high, which increases the technical difficulty and safety requirements of the equipment. One of the more mature ways to generate nanosecond pulses is to use a thyristor-type linear modulator, which has a simple circuit and low cost. When using nanosecond IRE equipment for treatment, a host of high-voltage nanosecond pulses and electrodes that introduce pulse energy into biological tissues are required. The arrangement of electrodes directly affects the ablation effect. When the electrodes are arranged too close or the tissue is broken down, arcs are easily generated. The arcs will form adverse reactions such as heat and pores, affecting the safety and effectiveness of treatment. The current nanosecond IRE equipment only detects short circuits. Since the current amplitude of the nanosecond pulse equipment using a thyristor linear modulator does not change significantly when an arc is generated, the short circuit detection fails, and the arc cannot be responded to in time, affecting safety and effectiveness. Since the current amplitude does not change significantly, it is impossible to accurately judge the current pulse and the occurrence of the fault arc. People have conducted a lot of research on this. Summary of the invention

[0003] The technical problem to be solved by the present invention is to provide an arc detection device and method for a nanosecond pulse irreversible electroporation device, which can detect the output pulse waveform in real time, and can determine whether the arc is generated inside the host or the arc is generated by the electrode load part. When the arc is formed, timely feedback is given to make the ablation process safer and more effective.

[0004] The present invention is achieved through the following technical scheme: an arc detection device for a nanosecond pulse irreversible electroporation device, comprising a first electrode, a second electrode, a high-voltage pulse module, a switch module, a resistor module, a high-frequency coil module, a circuit modulation module, a differential AD module and a processing chip module, wherein the first electrode and the second electrode are electrically connected to the high-voltage pulse module, the high-frequency coil module is electrically connected to the high-voltage pulse module, the circuit modulation module is electrically connected to the high-frequency coil module, the differential AD module is electrically connected to the circuit modulation module, the processing chip module is electrically connected to the differential AD module, the processing chip module is electrically connected to the high-voltage pulse module, and the switch module and the resistor module are electrically connected between the high-frequency coil module and the high-voltage pulse module.

[0005] A further technical solution is that the high-frequency coil module collects the analog quantity of the current, the circuit modulation module attenuates the analog quantity of the current and converts it into a differential mode, converts it into a digital quantity through the differential AD module and then transmits it to the processing chip module, the processing chip module judges the collected data, and if an arc alarm is found, the high-voltage pulse module is cut off from sending pulses and a prompt signal is issued.

[0006] In a further technical solution, the switch module includes a switch K1 and a switch K2, the resistor module includes a resistor R1, the switch K1 and the resistor R1 are electrically connected, the switch K1 and the resistor R1 are electrically connected between the first electrode and the second electrode, the switch K2 is electrically connected between the switch K1 and the first electrode, the high-frequency coil module includes a first high-frequency coil and a second high-frequency coil, the first high-frequency coil is electrically connected between the switch K2 and the first electrode, the second high-frequency coil is electrically connected between the resistor R1 and the second electrode, and the first high-frequency coil and the second high-frequency coil are electrically connected to the circuit modulation module.

[0007] As a further technical solution, the switch K1 and the switch K2 may be switches such as high voltage normally open relays, contactors or thyristors.

[0008] According to a further technical solution, the value of the resistor R1 is between 50Ω and 300Ω.

[0009] According to a further technical solution, the first high-frequency line is used to detect the current flowing through the first electrode, the second electrode and the biological tissue, and the second high-frequency coil is used to detect the pulse current flowing through the resistor R1.

[0010] A further technical solution also includes a method for detecting an internal electrical fault of a host computer using an arc detection device of a nanosecond pulse irreversible electroporation device: the first step is to store a current characteristic waveform of "a normal pulse emitted by a thyristor-type linear modulator" in a processing chip module;

[0011] In the second step, the switch K1 is closed, the switch K2 is opened, and the high-voltage pulse module generates a pulse to discharge R1;

[0012] In the third step, the second high-frequency coil collects the analog current flowing through the resistor R1, and converts it into a digital quantity through the circuit modulation module and the differential AD module and transmits it to the processing chip module;

[0013] In the fourth step, the processing chip module compares the digital value with the current characteristic waveform pre-stored on the processing chip module, where the current characteristic waveform includes the amplitude at the continuous sampling points;

[0014] Step 5. When the processing chip module determines that the waveform is abnormal, the high-voltage pulse module output is stopped and a prompt is given.

[0015] A further technical solution also includes a method for detecting arc faults generated by electrodes using an arc detection device of a nanosecond pulse irreversible electroporation device: in the first step, the switch K1 is opened, the switch K2 is closed, and the high-voltage pulse module generates pulses after operation, and discharges to biological tissues through the first electrode and the second electrode;

[0016] In the second step, the first high-frequency coil collects the pulse current waveform and forms a pulse waveform, and converts it into a digital quantity through the circuit modulation module and the differential AD module and transmits it to the processing chip module, and the first waveform adopted is stored in the processing chip module;

[0017] In the third step, the first high-frequency coil continues to collect the pulse current waveform and forms a pulse waveform, and converts it into a digital quantity through the circuit modulation module and the differential AD module and transmits it to the processing chip module, and the second waveform used is stored in the processing chip module;

[0018] In the fourth step, the processing chip module compares the latter pulse waveform with the former pulse waveform;

[0019] Step 5. When the deviation between the flat-top period of the next pulse waveform and the previous pulse is ≥20%, it is determined that an arc may be generated, the pulse output is stopped and a prompt is given.

[0020] The beneficial effects of the present invention are as follows: by setting up a high-voltage pulse module, a switch module, a resistor module, a high-frequency coil module, a circuit modulation module, a differential AD module and a processing chip module, the current pulse signal can be captured by the high-frequency coil module and then converted into a digital signal in the processing chip module. The processing chip module judges the collected data. If an arc alarm is found, the high-voltage pulse module is cut off from sending pulses and a prompt signal is issued. If it is normal, the high-voltage pulse module is kept sending pulses normally. Compared with the prior art, since the current amplitude of the nanosecond pulse device using a thyristor-type linear modulator does not change significantly when an arc is generated, the short-circuit detection fails, and the generated arc cannot be responded to in time, thereby improving safety.

[0021] By detecting electrical faults inside the host and arc faults generated by the electrode, the output pulse waveform can be detected in real time, and it can be determined whether the arc is generated inside the host or by the electrode load part. When an arc is formed, timely feedback is given to make the ablation process safer and more effective.

[0022] By detecting the pulse waveform in real time through the high-voltage coil module and comparing it with the pre-stored original pulse waveform or the previous pulse waveform, the data can be processed more quickly through the processing chip module, and then an instruction to interrupt the high-voltage pulse module can be issued.

[0023] In the method of detecting the fault arc generated by the electrode, when the deviation between the flat-top period of the latter pulse waveform and the previous pulse is ≥20%, it is judged that the arc may be generated, the pulse output is stopped and a prompt is given, which can effectively avoid the situation of misjudging the arc. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] For ease of explanation, the present invention is described in detail with reference to the following specific embodiments and accompanying drawings.

[0025] Figure 1 A schematic diagram of the circuit connection structure of an arc detection device of a nanosecond pulse irreversible electroporation device of the present invention;

[0026] Figure 2 This is a normal pulse waveform diagram emitted by a thyratron-type linear modulator;

[0027] Figure 3 This is the first abnormal pulse waveform diagram;

[0028] Figure 4 This is the second abnormal pulse waveform diagram;

[0029] Figure 5 This is the third abnormal pulse waveform diagram;

[0030] Figure 6 It is a schematic diagram of the working process of the arc detection device;

[0031] In the figure, there are a first electrode, a second electrode, a first high-frequency coil, a second high-frequency coil, a switch K1, a switch K2 and a resistor R1. DETAILED DESCRIPTION

[0032] like Figure 1-Figure 6 As shown, the present invention is described in detail. For the convenience of description, the directions mentioned below are defined as follows: the up, down, left, right, front and back directions mentioned below are Figure 1 The up-down, left-right, front-back directions of the projection relationship itself are consistent.

[0033] The arc detection device of a nanosecond pulse irreversible electroporation device of the present invention comprises a nanosecond pulse transmitting host, a first electrode and a second electrode. The biological tissue is ablated after the first electrode and the second electrode are energized.

[0034] Advantageously, the nanosecond pulse transmitting host includes a high-voltage pulse module, a switch module, a resistance module, a high-frequency coil module, a circuit modulation module, a differential AD module and a processing chip module, wherein the first electrode and the second electrode are electrically connected to the high-voltage pulse module, the high-frequency coil module is electrically connected to the high-voltage pulse module, the circuit modulation module is electrically connected to the high-frequency coil module, the differential AD module is electrically connected to the circuit modulation module, the processing chip module is electrically connected to the differential AD module, the processing chip module is electrically connected to the high-voltage pulse module, and the switch module and the resistance module are electrically connected between the high-frequency coil module and the high-voltage pulse module.

[0035] Advantageously, the high-frequency coil module collects analog current, the circuit modulation module attenuates the analog current and converts it into a differential mode, converts it into a digital quantity through a differential AD module and transmits it to the processing chip module, the processing chip module judges the collected data, if an arc alarm is found, the high-voltage pulse module is cut off from sending pulses and a prompt signal is issued; if normal, the high-voltage pulse module is kept sending pulses normally.

[0036] Advantageously, the switch module includes a switch K1 and a switch K2, the resistor module includes a resistor R1, the switch K1 and the resistor R1 are electrically connected, and the switch K1 and the resistor R1 are electrically connected between the first electrode and the second electrode, the switch K2 is electrically connected between the switch K1 and the first electrode, the high-frequency coil module includes a first high-frequency coil and a second high-frequency coil, the first high-frequency coil is electrically connected between the switch K2 and the first electrode, the second high-frequency coil is electrically connected between the resistor R1 and the second electrode, and the first high-frequency coil and the second high-frequency coil are electrically connected to the circuit modulation module.

[0037] Advantageously, the switch K1 and the switch K2 may be switches such as high-voltage normally open relays, contactors or thyristors.

[0038] Advantageously, the resistance of the resistor R1 is close to the impedance of the ablated biological tissue, generally between 50Ω and 300Ω.

[0039] Advantageously, the first high-frequency line is used to detect the current flowing through the first electrode, the second electrode and the biological tissue, and the second high-frequency coil is used to detect the pulse current flowing through the resistor R1.

[0040] Embodiment 1 also includes a method for detecting an internal electrical fault of a host computer using an arc detection device of a nanosecond pulse irreversible electroporation device: the first step is to store a current characteristic waveform of "a normal pulse emitted by a thyristor-type linear modulator" in a processing chip module;

[0041] In the second step, the switch K1 is closed, the switch K2 is opened, and the high-voltage pulse module generates a pulse to discharge R1;

[0042] In the third step, the second high-frequency coil collects the analog current flowing through the resistor R1, and converts it into a digital quantity through the circuit modulation module and the differential AD module and transmits it to the processing chip module;

[0043] In the fourth step, the processing chip module compares the digital value with the current characteristic waveform pre-stored on the processing chip module, where the current characteristic waveform includes the amplitude at the continuous sampling points;

[0044] Step 5. When the processing chip module determines that the waveform is abnormal, the high-voltage pulse module output is stopped and a prompt is given.

[0045] Advantageously, the instructions are attached Figure 2 The waveform recorded in the figure is a normal pulse emitted by a thyristor-type linear modulator, which is also used to store the waveform in the processing chip module. After the current characteristic waveform of the resistor R1 is collected later, the following waveform will be generated. Figure 3 If the current waveform in the measurement obviously fluctuates and the amplitudes of continuous samples are different, it is an abnormal situation. Since this method measures the current situation inside the nanosecond pulse sending host, it indirectly reflects the possibility of arc or fault, etc. In this case, it is necessary to stop the machine from working and use the processor module to send a warning message to inform the situation.

[0046] Embodiment 2 also includes a method for detecting arc faults generated by electrodes using an arc detection device of a nanosecond pulse irreversible electroporation device: in a first step, the switch K1 is opened, the switch K2 is closed, and the high-voltage pulse module generates pulses after operation, and discharges to biological tissues through the first electrode and the second electrode;

[0047] In the second step, the first high-frequency coil collects the pulse current waveform and forms a pulse waveform, and converts it into a digital quantity through the circuit modulation module and the differential AD module and transmits it to the processing chip module, and the first waveform adopted is stored in the processing chip module;

[0048] In the third step, the first high-frequency coil continues to collect the pulse current waveform and forms a pulse waveform, and converts it into a digital quantity through the circuit modulation module and the differential AD module and transmits it to the processing chip module, and the second waveform used is stored in the processing chip module;

[0049] In the fourth step, the processing chip module compares the latter pulse waveform with the former pulse waveform;

[0050] Step 5. When the deviation between the flat-top period of the next pulse waveform and the previous pulse is ≥20%, it is determined that an arc may be generated, the pulse output is stopped and a prompt is given.

[0051] Advantageously, stopping the pulse output means that the processing chip module controls the high-voltage pulse module to stop working.

[0052] Advantageously, when detecting the pulse waveform, it is necessary to continuously detect the pulse waveform and compare the latter pulse waveform with the former pulse waveform. Figure 5 Belongs to the latter pulse waveform, the instruction manual is attached Figure 4 It belongs to the previous pulse waveform. Obviously, the flat top period of the two waveforms deviates from the previous pulse by ≥20%. At this time, it will trigger the stop of pulse output and give a prompt.

[0053] The above are only specific implementation methods of the present invention, but the protection scope of the present invention is not limited to this. Any changes or substitutions that are not conceived through creative work should be included in the protection scope of the present invention; therefore, the protection scope of the present invention should be based on the protection scope defined in the claims.

Claims

1. An arc detection device for a nanosecond pulse irreversible electroporation device, comprising a first electrode, a second electrode, a high-voltage pulse module, a switch module, a resistor module, a high-frequency coil module, a circuit modulation module, a differential AD module and a processing chip module, characterized in that: The high-frequency coil module collects the analog quantity of the current, the circuit modulation module attenuates the analog quantity of the current and converts it into a differential mode, converts it into a digital quantity through the differential AD module and transmits it to the processing chip module, the processing chip module judges the collected data, and if an arc alarm is found, the high-voltage pulse module is cut off from sending pulses and a prompt signal is issued; The high-voltage pulse module is a thyratron-type linear modulator; The first electrode and the second electrode are electrically connected to the high-voltage pulse module, the high-frequency coil module is electrically connected to the high-voltage pulse module, the circuit modulation module is electrically connected to the high-frequency coil module, the differential AD module is electrically connected to the circuit modulation module, the processing chip module is electrically connected to the differential AD module, the processing chip module is electrically connected to the high-voltage pulse module, and the switch module and the resistance module are electrically connected between the high-frequency coil module and the high-voltage pulse module; The switch module includes a switch K1 and a switch K2, the resistor module includes a resistor R1, the switch K1 and the resistor R1 are electrically connected, the switch K1 and the resistor R1 are electrically connected between the first electrode and the second electrode, the switch K2 is electrically connected between the switch K1 and the first electrode, the high-frequency coil module includes a first high-frequency coil and a second high-frequency coil, the first high-frequency coil is electrically connected between the switch K2 and the first electrode, the second high-frequency coil is electrically connected between the resistor R1 and the second electrode, and the first high-frequency coil and the second high-frequency coil are electrically connected to the circuit modulation module; The method for detecting the internal fault of the host is as follows: first, a current characteristic waveform of a normal pulse emitted by a linear modulator using a thyristor is stored in the processing chip module; In the second step, the switch K1 is closed, the switch K2 is opened, and the high-voltage pulse module generates a pulse to discharge the resistor R1; In the third step, the second high-frequency coil collects the analog current flowing through the resistor R1, and converts it into a digital quantity through the circuit modulation module and the differential AD module and transmits it to the processing chip module; In the fourth step, the processing chip module compares the digital value with the current characteristic waveform pre-stored on the processing chip module, where the current characteristic waveform includes the amplitude at the continuous sampling points; Step 5: When the processing chip module determines that the waveform is abnormal, the high voltage pulse module output is stopped and a prompt is given; The method for detecting the fault arc generated in the electrode load part is as follows: in the first step, the switch K1 is opened, the switch K2 is closed, and the high-voltage pulse module generates a pulse after working, and discharges to the biological tissue through the first electrode and the second electrode; In the second step, the first high-frequency coil collects the pulse current waveform and forms a pulse waveform, and converts it into a digital quantity through the circuit modulation module and the differential AD module and transmits it to the processing chip module; In the third step, the first high-frequency coil continues to collect the pulse current waveform and forms a pulse waveform, and is converted into a digital quantity through the circuit modulation module and the differential AD module and transmitted to the processing chip module; In the fourth step, the processing chip module compares the latter pulse waveform with the former pulse waveform; Step 5. When the deviation between the flat-top period of the next pulse waveform and the previous pulse is ≥20%, it is determined that an arc may be generated, the pulse output is stopped and a prompt is given.

2. The arc detection device of the nanosecond pulse irreversible electroporation device according to claim 1, characterized in that: The switch K1 and the switch K2 are either high voltage normally open relays, contactors or thyristor switches.

3. The arc detection device of the nanosecond pulse irreversible electroporation device according to claim 1, characterized in that: The value of the resistor R1 is between 50Ω and 300Ω.

4. The arc detection device for nanosecond pulse irreversible electroporation equipment according to claim 1, characterized in that: The first high-frequency line is used to detect the current flowing through the first electrode, the second electrode and the biological tissue, and the second high-frequency coil is used to detect the pulse current flowing through the resistor R1.

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