Device, method, electronic device and storage medium for determining field angle

Abstract

The present application discloses a device, method, electronic device and storage medium for determining a field angle, and relates to the field of medical technology. The device includes: an acquisition unit for acquiring a field set, wherein the field set includes N field angles; a setting unit for setting M clinical targets; a first determination unit for determining the field intensity corresponding to each field angle in the field set according to the Lth clinical target, and obtaining the field intensity distribution information corresponding to the Lth clinical target; a second determination unit for determining X target field angles from N field angles according to the M field intensity distribution information corresponding to the M clinical targets, wherein the target field angle is the field angle used to formulate a radiotherapy plan. The present application solves the technical problem of low efficiency in determining the field angle in the prior art, which is caused by the use of a heuristic algorithm to select the field angle, because the selection process takes a long time.

Description

Technical Field

[0001] The present application relates to the field of medical technology, and more specifically, to a device, method, electronic device and storage medium for determining a radiation field angle. Background Art

[0002] IMRT (Intensity Modulated Radiation Therapy) has developed into an effective way to treat tumors clinically. This treatment method can produce conformal dose distribution in the target area while avoiding excessive irradiation of endangered organs. However, since the entire planning process involves many possible parameter combinations, obtaining the optimal IMRT plan is a complex and time-consuming process. Therefore, it is necessary to reduce the complexity of IMRT by improving the entire reverse planning process from the definition of clinical goals to dose calculation.

[0003] Currently, the field angle selection process in IMRT is mainly based on the experience of the physicist or through trial and error. Appropriate field angle selection is very important for planning with a small number of fields (e.g., 1-4 fields) and is also very useful for planning with more fields (e.g., 9 fields) in complex cases. In general, the optimization of field angles may have an important impact on the quality of IMRT treatment. The radiotherapy effect of a radiotherapy plan formulated with optimized field angles may be equivalent to or even better than that of a plan formulated with unoptimized field angles. In addition, in a radiotherapy plan, a small number of fields usually use a shorter treatment time, so the probability of related errors due to patient movement during treatment is also lower.

[0004] In addition, there are many optimization algorithms for selecting the field angle, among which the genetic algorithm is the most commonly used one, and simulated annealing and fast simulated annealing algorithms are also used by many researchers. However, this heuristic algorithm usually explores a large number of candidate solutions to obtain the optimal field angle, which greatly prolongs the entire process of field angle selection in IMRT. Therefore, although it is feasible to use genetic algorithms and simulated annealing to solve the field angle optimization problem, the convergence speed is not satisfactory from a computational point of view, especially for routine clinical applications.

[0005] To address the above-mentioned problems, no effective solution has been proposed yet. Summary of the invention

[0006] The present application provides a device, method, electronic device and storage medium for determining a field angle, so as to at least solve the technical problem in the prior art of using a heuristic algorithm to select a field angle, where the selection process takes a long time, resulting in low efficiency in determining the field angle.

[0007] According to one aspect of an embodiment of the present application, a device for determining a field angle is provided, including: an acquisition unit, used to acquire a field set, wherein the field set includes N field angles, wherein N is an integer greater than 1; a setting unit, used to set M clinical targets, wherein M is an integer greater than 1; a first determination unit, used to determine the field intensity corresponding to each field angle in the field set according to the Lth clinical target, and obtain the field intensity distribution information corresponding to the Lth clinical target, wherein L is a positive integer less than or equal to M; a second determination unit, used to determine X target field angles from the N field angles according to the M field intensity distribution information corresponding to the M clinical targets, wherein X is an integer less than or equal to N and greater than or equal to 1, and the target field angle is the field angle used to formulate a radiotherapy plan.

[0008] Optionally, in the device for determining the field angle provided in the present application, the acquisition unit includes: a first acquisition subunit, used to acquire geometric features of a target area of ​​a target object in a medical image, wherein the target area represents an outlined area of ​​an organ at risk and / or a target area of ​​the target object in the medical image; a first determination subunit, used to determine an initial field angle according to the geometric features of the target area; a first processing subunit, used to set an intermediate field angle at every preset angle starting from the initial field angle until N-1 intermediate field angles are set; and a second processing subunit, used to combine the initial field angle and the N-1 intermediate field angles into a field set.

[0009] Optionally, in the device for determining the field angle provided in the present application, the setting unit includes: a first setting subunit, used to set a first category of clinical targets, wherein the first category of clinical targets includes at least one clinical parameter value in a radiotherapy process; a target operation execution subunit, used to perform at least one target operation on the first category of clinical targets, wherein each target operation is used to generate a second category of clinical targets by modifying the clinical parameter values ​​in the first category of clinical targets; and a third processing subunit, used to take the first category of clinical targets and the second category of clinical targets generated by each target operation as M clinical targets.

[0010] Optionally, in the device for determining the field angle provided in the present application, the first determination unit includes: a second setting subunit, used to set the constraint conditions of the Lth clinical objective, wherein the constraint conditions of the Lth clinical objective are used to ensure that the calculated radiotherapy dose information can achieve the Lth clinical objective; a second determination subunit, used to determine the field intensity corresponding to each field angle in the field set based on the constraint conditions of the Lth clinical objective, and obtain the field intensity distribution information corresponding to the Lth clinical objective.

[0011] Optionally, in the device for determining the field angle provided in the present application, the second determination unit includes: a third determination subunit, used to determine the disturbance score of each of the N field angles based on M field intensity distribution information corresponding to the M clinical targets, wherein the disturbance score of each field angle represents the degree to which the field intensity of each field angle is disturbed during the execution of the radiotherapy plan; and a fourth determination subunit, used to determine X target field angles from the N field angles based on the disturbance score of each of the N field angles.

[0012] Optionally, in the device for determining the field angle provided in the present application, the third determination subunit includes: a calculation module, which is used to calculate the average value of Y field intensity distribution information corresponding to Y second-category clinical targets when there are Y second-category clinical targets among M clinical targets, to obtain target field intensity distribution information, wherein Y is an integer greater than 1; a first processing module, which is used to use the field intensity distribution information corresponding to the first-category clinical target as initial field intensity distribution information; and a disturbance score determination module, which is used to determine the disturbance score of each of the N field angles based on the target field intensity distribution information and the initial field intensity distribution information.

[0013] Optionally, in the device for determining the field angle provided in the present application, the third determination subunit includes: a third processing module, used to use the field intensity distribution information corresponding to the second type of clinical target as the target field intensity distribution information when there is only one second type of clinical target among the M clinical targets; a fourth processing module, used to use the field intensity distribution information corresponding to the first type of clinical target as the initial field intensity distribution information; a disturbance score determination module, used to determine the disturbance score of each of the N field angles based on the target field intensity distribution information and the initial field intensity distribution information.

[0014] Optionally, in the device for determining the field angle provided in the present application, the disturbance score determination module includes: a first processing submodule, used to use the field intensity of the kth field angle recorded in the target field intensity distribution information as the first field intensity of the kth field angle, wherein the kth field angle is any field angle in the field set; a second processing submodule, used to use the field intensity of the kth field angle recorded in the initial field intensity distribution information as the second field intensity of the kth field angle; and a third processing submodule, used to determine the disturbance score of the kth field angle based on the first field intensity and the second field intensity of the kth field angle.

[0015] Optionally, in the device for determining the field angle provided in the present application, the fourth determination subunit includes: a sorting module, used to sort N field angles according to the disturbance score of each field angle to obtain a sorting result; a target field angle determination module, used to determine X target field angles from the N field angles according to the sorting result and the target strategy, wherein the target strategy is used to select the minimum number of field angles when the initial field intensity of the selected field angle can achieve at least one of the M clinical goals.

[0016] According to another aspect of the present application, a method for determining a field angle is also provided, which includes: obtaining a field set, wherein the field set includes N field angles, wherein N is an integer greater than 1; setting M clinical targets, wherein M is an integer greater than 1; determining the field intensity corresponding to each field angle in the field set according to the Lth clinical target, and obtaining the field intensity distribution information corresponding to the Lth clinical target, wherein L is a positive integer less than or equal to M; determining X target field angles from the N field angles according to the M field intensity distribution information corresponding to the M clinical targets, wherein X is an integer less than or equal to N and greater than or equal to 1, and the target field angle is the field angle used to formulate a radiotherapy plan.

[0017] According to another aspect of the present application, a computer-readable storage medium is also provided, wherein a computer program is stored in the computer-readable storage medium, wherein when the computer program runs, the device where the computer-readable storage medium is located controls the operation of the device for determining the field angle of any of the above items.

[0018] According to another aspect of the present application, an electronic device is also provided, wherein the electronic device includes one or more processors and a memory, the memory being used to store one or more programs, wherein when the one or more programs are executed by one or more processors, the one or more processors control the operation of the device for determining the field angle of any of the above items.

[0019] In the present application, a device for determining a field angle is provided, including an acquisition unit for acquiring a field set, wherein the field set includes N field angles, wherein N is an integer greater than 1; a setting unit for setting M clinical targets, wherein M is an integer greater than 1; a first determination unit for determining the field intensity corresponding to each field angle in the field set according to the Lth clinical target, and obtaining the field intensity distribution information corresponding to the Lth clinical target, wherein L is a positive integer less than or equal to M; a second determination unit for determining X target field angles from the N field angles according to the M field intensity distribution information corresponding to the M clinical targets, wherein X is an integer less than or equal to N and greater than or equal to 1, and the target field angle is a field angle used to formulate a radiotherapy plan.

[0020] From the above content, it can be seen that the present application sets M clinical targets, and then determines X target field angles from N field angles according to the M field intensity distribution information corresponding to the M clinical targets. Compared with manually setting the field angle, it can greatly reduce labor costs and improve the efficiency of determining the field angle, and will not be affected by the subjective influence of manual experience. The final determined field angle is more objective and accurate. In addition, the field angle screening algorithm of the present application is mainly based on the field intensity distribution information, rather than the traditional heuristic algorithm. Therefore, the field angle screening is performed according to the technical solution of the present application. The whole process takes less time and requires less computing resources, thereby solving the technical problem of low efficiency in determining the field angle due to the long time required for the selection process using a heuristic algorithm to select the field angle in the prior art. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] The drawings described herein are used to provide a further understanding of the present application and constitute a part of the present application. The illustrative embodiments of the present application and their descriptions are used to explain the present application and do not constitute an improper limitation on the present application. In the drawings:

[0022] Figure 1 is a schematic diagram of an optional device for determining a field angle according to an embodiment of the present application;

[0023] Figure 2 It is a flowchart of an optional method for determining a field angle according to an embodiment of the present application. DETAILED DESCRIPTION

[0024] In order to enable those skilled in the art to better understand the solution of the present application, the technical solution in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work should fall within the scope of protection of the present application.

[0025] It should be noted that the terms "first", "second", etc. in the specification and claims of the present application and the above-mentioned drawings are used to distinguish similar objects, and are not necessarily used to describe a specific order or sequence. It should be understood that the data used in this way can be interchangeable where appropriate, so that the embodiments of the present application described herein can be implemented in an order other than those illustrated or described herein. In addition, the terms "including" and "having" and any of their variations are intended to cover non-exclusive inclusions, for example, a process, method, system, product or device comprising a series of steps or units is not necessarily limited to those steps or units clearly listed, but may include other steps or units that are not clearly listed or inherent to these processes, methods, products or devices.

[0026] It should also be noted that the information (including but not limited to user device information, user personal information, etc.) and data (including but not limited to data used for analysis, stored data, displayed data, etc.) collected by this application are information and data authorized by the user or fully authorized by all parties, and the collection, storage, use, processing, transmission, provision, disclosure and application of relevant data are in compliance with the relevant laws, regulations and standards of the relevant regions, necessary confidentiality measures are taken, and public order and good customs are not violated, and corresponding operation portals are provided for users to choose to authorize or refuse. For example, an interface is set up between this system and relevant users or institutions. Before obtaining relevant information, it is necessary to send an acquisition request to the aforementioned user or institution through the interface, and obtain relevant information after receiving the consent information fed back by the aforementioned user or institution.

[0027] According to an embodiment of the present application, an embodiment of a device for determining a field angle is provided, wherein: Figure 1 is a schematic diagram of an optional device for determining a field angle according to an embodiment of the present application, such as Figure 1 As shown, the device for determining the field angle includes: an acquisition unit 101 , a setting unit 102 , a first determination unit 103 , and a second determination unit 104 .

[0028] Optionally, the device for determining the field angle can be a software system, an embedded system combining software and hardware, or a device. Those skilled in the art should be aware that the present application does not specifically limit the specific form of the device for determining the field angle.

[0029] Optionally, the acquisition unit 101 is used to acquire a field set, wherein the field set includes N field angles, wherein N is an integer greater than 1.

[0030] Optionally, during radiotherapy, the field and the field angle are two important concepts, which play an important role in ensuring the treatment effect and reducing the damage to normal tissue. Among them, the field refers to a specific area in the patient's body where the radiation is irradiated during radiotherapy. In the radiotherapy plan, the doctor will determine the range of the field according to the location, size and shape of the tumor, as well as the sensitivity of the surrounding normal tissue. The determination of the field needs to take into account the three-dimensional structure of the tumor so that the tumor cells can be accurately irradiated while minimizing damage to normal tissue. The field angle refers to the angle between the radiation beam and the patient's body surface. During radiotherapy, the doctor will choose a suitable field angle to irradiate the tumor according to the location and shape of the tumor. Different field angles can change the incident direction of the radiation beam, thereby achieving multi-angle irradiation of the tumor. Multi-angle irradiation helps to improve the treatment effect while reducing damage to normal tissue.

[0031] Optionally, 0 to 360 degrees is used as the sampling interval of the field angle, and a field angle is determined every 10 degrees, so 36 field angles can be determined to form a field set. Of course, the interval angle can also be selected in other degrees, and the number of field angles in the field set can also be not fixed. In addition to determining the field angle according to the interval angle, the user can also randomly or specify N field angles to form a field set.

[0032] In an optional embodiment, the setting unit 102 is used to set M clinical objectives, where M is an integer greater than 1.

[0033] Optionally, the clinical goal refers to a preset condition parameter value related to the clinical goal of the patient. The clinical goal includes at least target dose information set by the doctor for the target object, for example, the target dose information includes at least the minimum irradiation dose expected by the doctor for the target organ of the target object, the maximum irradiation dose expected by the doctor for each organ at risk of the target object, and the like.

[0034] For example, assume that M clinical objectives include the first clinical objective and the second clinical objective. The first clinical objective requires that the D95 dose of PTV (Patient Target Volume, which refers to the area that needs to receive radiotherapy during tumor treatment) is 50Gy, and the maximum dose of OAR (Organ at Risk) is 40Gy; the second clinical objective requires that the D95 dose of PTV is 55Gy, and the maximum dose of OAR is 36Gy.

[0035] It should be noted that the above-mentioned first clinical objective and second clinical objective are merely examples. In actual applications, the number of selected clinical objectives may not be limited, and the user may flexibly set specific parameters of each clinical objective according to actual scenarios.

[0036] In an optional embodiment, the first determination unit 103 is used to determine the field intensity corresponding to each field angle in the field set based on the Lth clinical target, and obtain the field intensity distribution information corresponding to the Lth clinical target, where L is a positive integer less than or equal to M.

[0037] Optionally, assuming that the Lth clinical target is the first clinical target, and the field set includes 36 field angles, the first determination unit 103 can determine the field intensity corresponding to each of the 36 field angles according to the first clinical target, and on this basis, the 36 field intensities corresponding to the 36 field angles constitute the field intensity distribution information corresponding to the first clinical target. Similarly, the field intensity distribution information corresponding to the second clinical target can be obtained.

[0038] Optionally, the field intensity corresponding to each field angle in the field set can be determined according to the Lth clinical objective through calculation methods such as Monte Carlo, or the field intensity corresponding to each field angle in the field set can be determined according to the Lth clinical objective through a pre-trained neural network model.

[0039] In an optional embodiment, the second determination unit 104 is used to determine X target field angles from N field angles based on M field intensity distribution information corresponding to M clinical targets, where X is an integer less than or equal to N and greater than or equal to 1, and the target field angle is the field angle used to formulate a radiotherapy plan.

[0040] Optionally, after obtaining the field intensity distribution information corresponding to each clinical target, the second determination unit 104 can determine the disturbance score of each of the N field angles according to the field intensity distribution information corresponding to different clinical targets, wherein the disturbance score of each field angle represents the degree to which the field intensity of each field angle is disturbed during the execution of the radiotherapy plan. Finally, the second determination unit 104 determines X target field angles from the N field angles according to the disturbance score of each of the N field angles.

[0041] From the above content, it can be seen that the present application sets M clinical targets, and then determines X target field angles from N field angles according to the M field intensity distribution information corresponding to the M clinical targets. Compared with manually setting the field angle, it can greatly reduce labor costs and improve the efficiency of determining the field angle, and will not be affected by the subjective influence of manual experience. The final determined field angle is more objective and accurate. In addition, the field angle screening algorithm of the present application is mainly based on the field intensity distribution information, rather than the traditional heuristic algorithm. Therefore, the field angle screening is performed according to the technical solution of the present application. The whole process takes less time and requires less computing resources, thereby solving the technical problem of low efficiency in determining the field angle due to the long time required for the selection process using a heuristic algorithm to select the field angle in the prior art.

[0042] In an optional embodiment, the acquisition unit 101 includes: a first acquisition subunit, a first determination subunit, a first processing subunit, and a second processing subunit.

[0043] Among them, the first acquisition subunit is used to obtain the geometric features of the target area of ​​the target object in the medical image, wherein the target area represents the outlined area of ​​the target object's organs at risk and / or the target area in the medical image; the first determination subunit is used to determine an initial field angle according to the geometric features of the target area; the first processing subunit is used to set an intermediate field angle at each preset angle starting from the initial field angle until N-1 intermediate field angles are set; the second processing subunit is used to combine the initial field angle and the N-1 intermediate field angles into a field set.

[0044] Optionally, medical images include but are not limited to the following:

[0045] X-ray imaging: Usually used to view bone structure, it can also be used to view chest organs such as the heart and lungs.

[0046] Computed tomography (CT): A scan that uses X-rays and computer technology to create detailed cross-sectional images of the body. It is often used to examine organs, blood vessels, and tumors.

[0047] Magnetic resonance imaging (MRI): Uses a strong magnetic field and radio waves to obtain detailed images of the body’s soft tissues. It is often used to examine the brain, muscles, and joints.

[0048] Positron emission tomography (PET): This technique assesses the metabolic activity of organs and tissues by detecting the distribution of radioactive tracers in the body. It is often used in cancer diagnosis and brain disease research.

[0049] Ultrasound imaging: Uses the reflection of high-frequency sound waves to produce real-time images of internal body structures. It is often used to examine the fetus, heart, blood vessels, and other internal organs.

[0050] Digital subtraction angiography (DSA): A special X-ray technique used to visualize blood vessels and blood flow.

[0051] Optionally, the target area is also called the ROI outline area of ​​the target object. An initial field angle is determined based on the geometric characteristics of the ROI outline area, so that the clinical goal can be achieved as much as possible at the beginning of irradiation, and then subsequent field angles are selected for supplementary irradiation, so as to achieve the overall clinical goal with as few fields as possible.

[0052] Optionally, assuming that N is 36, the sampling interval of the field angle is 0 to 360 degrees, after determining an initial field angle according to the geometric characteristics of the target area, an intermediate field angle can be determined every 10 degrees (corresponding to the above-mentioned preset angle) in the sampling interval, thereby obtaining 35 intermediate field angles. Finally, the initial field angle and the 35 intermediate field angles can be combined into a field set.

[0053] In an optional embodiment, the setting unit 102 includes: a first setting subunit, a target operation execution subunit, and a third processing subunit.

[0054] Optionally, a first setting subunit is used to set a first category of clinical targets, wherein the first category of clinical targets includes at least one clinical parameter value in a radiotherapy process; a target operation execution subunit is used to perform at least one target operation on the first category of clinical targets, wherein each target operation is used to generate a second category of clinical targets by modifying the clinical parameter values ​​in the first category of clinical targets; and a third processing subunit is used to take the first category of clinical targets and the second category of clinical targets generated by each target operation as M clinical targets.

[0055] Optionally, the first type of clinical objectives can be understood as basic clinical objectives or lower limit clinical objectives set for the target object, that is, the most basic clinical objectives that doctors need to achieve when performing radiotherapy on the target object.

[0056] Optionally, the second type of clinical goal is a more stringent clinical goal adjusted on the basis of the first type of clinical goal. Generally speaking, when performing radiotherapy on the target object, the doctor most hopes that the radiotherapy result can achieve the second type of clinical goal. However, if the second type of clinical goal is difficult to achieve, it is at least necessary to ensure that the first type of clinical goal is achieved.

[0057] Optionally, the clinical parameter values ​​include but are not limited to the minimum irradiation dose of the PTV and the maximum irradiation dose of the OAR.

[0058] For example, the second clinical goal (belonging to the second category of clinical goals) is modified based on the first clinical goal (i.e., the first category of clinical goals), increasing the D95 dose of the PTV and reducing the maximum dose of the OAR. For example, if the first clinical goal requires the D95 dose of the PTV to be 50 Gy and the maximum dose of the OAR to be 40 Gy, then the second clinical goal requires the D95 dose of the PTV to be 55 Gy and the maximum dose of the OAR to be 36 Gy.

[0059] An optional way to modify the clinical parameter values ​​is: the D95 dose of the PTV of the second clinical target is 1.1 times the D95 dose of the PTV of the first clinical target, and the maximum irradiation dose of the OAR of the second clinical target is 0.9 times the maximum irradiation dose of the OAR of the first clinical target.

[0060] From the above content, it can be seen that by modifying the first category of clinical objectives to obtain the second category of clinical objectives, not only the generation efficiency of the second category of clinical objectives can be improved, but also the credibility of each second category of clinical objectives can be guaranteed.

[0061] In an optional embodiment, the first determining unit 103 includes: a second setting subunit and a second determining subunit.

[0062] Optionally, the second setting subunit is used to set the constraint conditions of the Lth clinical objective, wherein the constraint conditions of the Lth clinical objective are used to ensure that the calculated radiotherapy dose information can achieve the Lth clinical objective; the second determination subunit is used to determine the field intensity corresponding to each field angle in the field set based on the constraint conditions of the Lth clinical objective, and obtain the field intensity distribution information corresponding to the Lth clinical objective.

[0063] Optionally, in the design of radiotherapy plan, it is very important to ensure that the intensity of the radiation field can meet the clinical goal. The following is a possible embodiment, which describes how to set the constraints of the clinical goal and determine the intensity of the radiation field:

[0064] First, the Lth clinical goal can be defined as achieving the maximum dose coverage of the PTV area while limiting the dose of the surrounding normal tissues (OAR, organs at risk) to not exceed the tolerance threshold. Then set the constraint condition: the minimum irradiation dose of the PTV area should reach 95% of the prescribed dose, that is, The maximum exposure dose to an OAR should not exceed 110% of its tolerance dose, i.e. Finally, the Inverse Planning System (IPS) was used to input the above constraints, and the system automatically optimized the field angle and intensity to meet the dose constraints of the clinical objectives.

[0065] In an optional embodiment, the second determining unit 104 includes: a third determining subunit and a fourth determining subunit.

[0066] Optionally, a third determination subunit is used to determine a disturbance score for each of the N field angles based on M field intensity distribution information corresponding to the M clinical targets, wherein the disturbance score for each field angle represents the degree to which the field intensity of each field angle is disturbed during the execution of the radiotherapy plan; and a fourth determination subunit is used to determine X target field angles from the N field angles based on the disturbance score for each of the N field angles.

[0067] Optionally, the perturbation score may also be referred to as BIPPS, where BIPPS is a metric score of the extent to which the intensity distribution of a set of predefined fields is perturbed during plan execution when the normal constraints of the radiotherapy plan are tightened.

[0068] Alternatively, it is assumed that within the feasible field angle range (e.g., 0 to 360 degrees), the field set with a higher perturbation score, that is, the field angle with a higher BIPPS, will be the appropriate field angle. Therefore, the sorting function can give the required number of appropriate field angles in a specified situation based on the BIPPS of all field angles.

[0069] It should be noted that the interpretation of the above hypothesis is that when the normal constraints become more stringent, the field intensity will experience relatively greater perturbations. Therefore, when the normal constraints become more stringent, the intensity of a suitable field angle will experience relatively enhanced perturbations, while an inappropriate field angle will not. Therefore, finding a field angle with a higher BIPPS value will imply that the selected field angle is relatively more suitable for IMRT in terms of geometry and dosimetry.

[0070] Based on this assumption, the process of determining the formulated parameter BIPPS can be used as a means to rank the field angles in IMRT, which in turn can be used to select the most appropriate field set in IMRT. In addition, finding the appropriate field angle in IMRT can significantly reduce the field selection time.

[0071] In an optional embodiment, the third determination subunit includes: a calculation module, a first processing module, and a disturbance score determination module.

[0072] Optionally, a calculation module is used to calculate the average value of Y field intensity distribution information corresponding to Y second-category clinical targets when there are Y second-category clinical targets among M clinical targets, so as to obtain target field intensity distribution information; a first processing module is used to use the field intensity distribution information corresponding to the first-category clinical targets as initial field intensity distribution information; and a disturbance score determination module is used to determine the disturbance score of each of N field angles based on the target field intensity distribution information and the initial field intensity distribution information.

[0073] Optionally, if there are Y clinical targets of the second category, the calculation module can use the average value of the Y field intensity distribution information as the target field intensity distribution information. It should be noted that the more the number of second-category clinical targets, the higher the credibility of the target field intensity distribution information, and the more accurate the disturbance score determined by the subsequent use of the target field intensity distribution information. However, calculating the field intensity distribution information corresponding to too many second-category clinical targets will consume more computing resources.

[0074] Optionally, the first processing module is used to use the field intensity distribution information corresponding to the first type of clinical target as the initial field intensity distribution information. Finally, the disturbance score determination module determines the disturbance score of each of the N field angles according to the target field intensity distribution information and the initial field intensity distribution information.

[0075] In an optional embodiment, the third determination subunit also includes: a third processing module, used to use the field intensity distribution information corresponding to the second type of clinical target as the target field intensity distribution information when there is only one second type of clinical target among the M clinical targets; a fourth processing module, used to use the field intensity distribution information corresponding to the first type of clinical target as the initial field intensity distribution information; a disturbance score determination module, used to determine the disturbance score of each of the N field angles based on the target field intensity distribution information and the initial field intensity distribution information.

[0076] Optionally, there may be only one second-category clinical target. In this case, the third processing module can use the field intensity distribution information corresponding to the only second-category clinical target as the target field intensity distribution information. Since only the field intensity distribution information corresponding to one second-category clinical target needs to be processed, excessive consumption of computing resources can be avoided and the calculation speed of the disturbance score can be improved.

[0077] In an optional embodiment, the disturbance score determination module includes: a first processing submodule, a second processing submodule, and a third processing submodule.

[0078] Optionally, the first processing submodule is used to use the field intensity of the kth field angle recorded in the target field intensity distribution information as the first field intensity of the kth field angle, wherein the kth field angle is any field angle in the field set; the second processing submodule is used to use the field intensity of the kth field angle recorded in the initial field intensity distribution information as the second field intensity of the kth field angle; and the third processing submodule is used to determine the disturbance score of the kth field angle based on the first field intensity and the second field intensity of the kth field angle.

[0079] Optionally, the disturbance score BIPPS calculation method for any field angle can refer to the following formula (1).

[0080]

[0081] Alternatively, in formula (1), the field intensity distribution information can be considered as a A two-dimensional matrix of . Among them, is the field angle The intensity value of the i-th row and j-th column in the two-dimensional matrix corresponding to the initial field intensity distribution information, is the field angle The intensity value of the i-th row and j-th column in the two-dimensional matrix corresponding to the target field intensity distribution information.

[0082] By using the above formula (1), the disturbance score BIPPS of each of the N field angles can be calculated.

[0083] In an optional embodiment, the fourth determination subunit includes: a sorting module and a target field angle determination module.

[0084] Optionally, a sorting module is used to sort N field angles according to the disturbance score of each field angle to obtain a sorting result; and a target field angle determination module is used to determine X target field angles from the N field angles according to the sorting result and a target strategy, wherein the target strategy is used to select a minimum number of field angles when an initial field intensity of the selected field angle can achieve at least one of the M clinical goals.

[0085] Optionally, after sorting the N field angles according to the disturbance score of each field angle and obtaining the sorting result, the target field angle determination module can select the first s field angles in order based on the sorting result, where s is an integer greater than or equal to 1, for example, s=3. First, the selected s field angles and the constraints of the initial field intensity distribution information are used as planning parameters of the radiotherapy plan, and then the dose calculation is performed. If the result of the dose calculation meets the first type of clinical goal, the loop is exited, and the field-related parameters of this cycle are the final result of the algorithm. If the dose calculation result does not meet the first type of clinical requirements, s+1 field angles are selected in order to perform dose calculation until the dose calculation result meets the requirements.

[0086] It can be seen from the above content that the technical solution of this application can at least achieve the following technical effects:

[0087] 1. The angle and number of radiation fields determined by the algorithm in this application can ensure that a higher dose covers the target area and reduces the dose to healthy tissues.

[0088] 2. This application can generate a flatter and more uniform dose distribution according to dose constraints and optimization goals, which helps reduce dose inhomogeneity and the occurrence of side effects.

[0089] 3. This application can greatly reduce the time and energy consumed by physiotherapists in designing treatment plans.

[0090] 4. This application can reduce human errors caused by the subjectivity and personal experience of physicists.

[0091] According to another aspect of the present application, a method for determining a field angle is also provided, wherein: Figure 2 is a flow chart of an optional method for determining a field angle according to an embodiment of the present application, such as Figure 2 As shown, the following steps are included:

[0092] Step S201, obtaining a field set.

[0093] In step S201, the field set includes N field angles, where N is an integer greater than 1.

[0094] In radiotherapy, the field of view and the field angle are two important concepts, which play an important role in ensuring the treatment effect and reducing the damage to normal tissue. Among them, the field of view refers to a specific area in the patient's body where the radiation is irradiated during radiotherapy. In the radiotherapy plan, the doctor will determine the range of the field of view based on the location, size and shape of the tumor, as well as the sensitivity of the surrounding normal tissue. The determination of the field of view needs to take into account the three-dimensional structure of the tumor so that the tumor cells can be accurately irradiated while minimizing damage to normal tissue. The field angle refers to the angle between the radiation beam and the patient's body surface. In radiotherapy, the doctor will choose the appropriate field angle to irradiate the tumor according to the location and shape of the tumor. Different field angles can change the incident direction of the radiation beam, thereby achieving multi-angle irradiation of the tumor. Multi-angle irradiation helps to improve the treatment effect while reducing damage to normal tissue.

[0095] Optionally, 0 to 360 degrees is used as the sampling interval of the field angle, and a field angle is determined every 10 degrees, so 36 field angles can be determined to form a field set. Of course, the interval angle can also be selected in other degrees, and the number of field angles in the field set can also be not fixed. In addition to determining the field angle according to the interval angle, the user can also randomly or specify N field angles to form a field set.

[0096] Step S202, setting M clinical objectives.

[0097] In step S202, M is an integer greater than 1.

[0098] Optionally, the clinical goal includes at least target dose information set by the doctor for the target object. For example, the target dose information includes at least the minimum radiation dose expected by the doctor for the target organ of the target object, the maximum radiation dose expected by the doctor for each endangered organ of the target object, and so on.

[0099] For example, assume that the M clinical objectives include a first clinical objective and a second clinical objective, wherein the first clinical objective requires a D95 dose of 50 Gy for PTV and a maximum dose of 40 Gy for OAR, and the second clinical objective requires a D95 dose of 55 Gy for PTV and a maximum dose of 36 Gy for OAR.

[0100] It should be noted that the above-mentioned first clinical objective and second clinical objective are merely examples. In actual applications, the number of selected clinical objectives may not be limited, and the user may flexibly set specific parameters of each clinical objective according to actual scenarios.

[0101] Step S203, determining the field intensity corresponding to each field angle in the field set according to the Lth clinical target, and obtaining the field intensity distribution information corresponding to the Lth clinical target.

[0102] In step S203, L is a positive integer less than or equal to M.

[0103] Optionally, assuming that the Lth clinical target is the first clinical target, and the field set includes 36 field angles, the first determination unit 103 can determine the field intensity corresponding to each of the 36 field angles according to the first clinical target, and on this basis, the 36 field intensities corresponding to the 36 field angles constitute the field intensity distribution information corresponding to the first clinical target. Similarly, the field intensity distribution information corresponding to the second clinical target can be obtained.

[0104] Optionally, the field intensity corresponding to each field angle in the field set can be determined according to the Lth clinical objective through calculation methods such as Monte Carlo, or the field intensity corresponding to each field angle in the field set can be determined according to the Lth clinical objective through a pre-trained neural network model.

[0105] Step S204: Determine X target field angles from the N field angles according to the M field intensity distribution information corresponding to the M clinical targets.

[0106] In step S204, X is an integer less than or equal to N and greater than or equal to 1, and the target field angle is the field angle used to formulate a radiotherapy plan.

[0107] Optionally, after obtaining the field intensity distribution information corresponding to each clinical target, the second determination unit 104 can determine the disturbance score of each of the N field angles according to the field intensity distribution information corresponding to different clinical targets, wherein the disturbance score of each field angle represents the degree to which the field intensity of each field angle is disturbed during the execution of the radiotherapy plan. Finally, the second determination unit 104 determines X target field angles from the N field angles according to the disturbance score of each of the N field angles.

[0108] From the above content, it can be seen that the present application sets M clinical targets, and then determines X target field angles from N field angles according to the M field intensity distribution information corresponding to the M clinical targets. Compared with manually setting the field angle, it can greatly reduce labor costs and improve the efficiency of determining the field angle, and will not be affected by the subjective influence of manual experience. The final determined field angle is more objective and accurate. In addition, the field angle screening algorithm of the present application is mainly based on the field intensity distribution information, rather than the traditional heuristic algorithm. Therefore, the field angle screening is performed according to the technical solution of the present application. The whole process takes less time and requires less computing resources, thereby solving the technical problem of low efficiency in determining the field angle due to the long time required for the selection process using a heuristic algorithm to select the field angle in the prior art.

[0109] According to another aspect of the present application, a computer-readable storage medium is also provided, wherein a computer program is stored in the computer-readable storage medium, wherein when the computer program runs, the device where the computer-readable storage medium is located controls the operation of the device for determining the field angle of any of the above items.

[0110] According to another aspect of the present application, an electronic device is also provided, wherein the electronic device includes one or more processors and a memory, the memory being used to store one or more programs, wherein when the one or more programs are executed by one or more processors, the one or more processors control the operation of the device for determining the field angle of any of the above items.

[0111] The serial numbers of the above-mentioned embodiments of the present application are for description only and do not represent the advantages or disadvantages of the embodiments.

[0112] In the above embodiments of the present application, the description of each embodiment has its own emphasis. For parts that are not described in detail in a certain embodiment, please refer to the relevant description of other embodiments.

[0113] In the several embodiments provided in this application, it should be understood that the disclosed technical content can be implemented in other ways. Among them, the device embodiments described above are only schematic. For example, the division of the units can be a logical function division. There may be other division methods in actual implementation. For example, multiple units or components can be combined or integrated into another system, or some features can be ignored or not executed. Another point is that the mutual coupling or direct coupling or communication connection shown or discussed can be through some interfaces, indirect coupling or communication connection of units or modules, which can be electrical or other forms.

[0114] The units described as separate components may or may not be physically separated, and the components shown as units may or may not be physical units, that is, they may be located in one place or distributed on multiple units. Some or all of the units may be selected according to actual needs to achieve the purpose of the present embodiment.

[0115] In addition, each functional unit in each embodiment of the present application may be integrated into one processing unit, or each unit may exist physically separately, or two or more units may be integrated into one unit. The above-mentioned integrated unit may be implemented in the form of hardware or in the form of software functional units.

[0116] If the integrated unit is implemented in the form of a software functional unit and sold or used as an independent product, it can be stored in a computer-readable storage medium. Based on this understanding, the technical solution of the present application, or the part that contributes to the prior art, or all or part of the technical solution can be embodied in the form of a software product. The computer software product is stored in a storage medium, including several instructions for a computer device (which can be a personal computer, server or network device, etc.) to execute all or part of the steps of the method described in each embodiment of the present application. The aforementioned storage medium includes: U disk, read-only memory (ROM, Read-Only Memory), random access memory (RAM, Random Access Memory), mobile hard disk, disk or optical disk, etc., which can store program code.

[0117] The above is only a preferred implementation of the present application. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present application. These improvements and modifications should also be regarded as the scope of protection of the present application.

Claims

1. A device for determining a field angle, characterized in that: include: An acquisition unit, used for acquiring a field set, wherein the field set includes N field angles, wherein N is an integer greater than 1; A setting unit, used for setting M clinical objectives, where M is an integer greater than 1; The first determination unit is used to determine the field intensity corresponding to each field angle in the field set according to the Lth clinical target, and obtain the field intensity distribution information corresponding to the Lth clinical target, wherein L is a positive integer less than or equal to M; the second determination unit is used to determine X target field angles from the N field angles according to the M field intensity distribution information corresponding to the M clinical targets, wherein X is an integer less than or equal to N and greater than or equal to 1, and the target field angle is the field angle used to formulate a radiotherapy plan; Wherein, the first determination unit includes: a second setting subunit, used to set the constraint conditions of the Lth clinical target, wherein the constraint conditions of the Lth clinical target are used to ensure that the calculated radiotherapy dose information can achieve the Lth clinical target; a second determination subunit, used to determine the field intensity corresponding to each field angle in the field set according to the constraint conditions of the Lth clinical target, and obtain the field intensity distribution information corresponding to the Lth clinical target; The second determination unit includes: a third determination subunit, used to determine the disturbance score of each of the N field angles based on the M field intensity distribution information corresponding to the M clinical targets, wherein the disturbance score of each field angle represents the degree to which the field intensity of each field angle is disturbed during the execution of the radiotherapy plan; and a fourth determination subunit, used to determine X target field angles from the N field angles based on the disturbance score of each of the N field angles.

2. The device for determining the field angle according to claim 1, characterized in that: The acquisition unit comprises: A first acquisition subunit is used to acquire geometric features of a target region of a target object in a medical image, wherein the target region represents an organ at risk and / or a delineated region of a target area of ​​the target object in the medical image; A first determination subunit is used to determine an initial field angle according to the geometric characteristics of the target area; A first processing subunit is used to set an intermediate field angle at every preset angle starting from the initial field angle until N-1 intermediate field angles are set; The second processing subunit is used to combine the initial field angle and the N-1 intermediate field angles into the field set.

3. The device for determining the field angle according to claim 1, characterized in that: The setting unit comprises: A first setting subunit, configured to set a first type of clinical target, wherein the first type of clinical target includes at least one clinical parameter value during radiotherapy; a target operation execution subunit, configured to perform at least one target operation on the first-category clinical target, wherein each target operation is used to generate a second-category clinical target by modifying a clinical parameter value in the first-category clinical target; The third processing subunit is used to use the first category of clinical objectives and the second category of clinical objectives generated by each target operation as the M clinical objectives.

4. The device for determining the field angle according to claim 3, characterized in that: The third determining subunit comprises: a calculation module, configured to calculate, when there are Y second-category clinical targets among the M clinical targets, an average value of Y radiation field intensity distribution information corresponding to the Y second-category clinical targets, to obtain target radiation field intensity distribution information, wherein Y is an integer greater than 1; A first processing module, configured to use the radiation field intensity distribution information corresponding to the first type of clinical target as initial radiation field intensity distribution information; A disturbance score determination module is used to determine the disturbance score of each of the N field angles according to the target field intensity distribution information and the initial field intensity distribution information.

5. The device for determining the field angle according to claim 3, characterized in that: The third determining subunit comprises: A third processing module is used for, when there is only one clinical target of the second category among the M clinical targets, using the radiation field intensity distribution information corresponding to the second clinical target as the target radiation field intensity distribution information; A fourth processing module, configured to use the radiation field intensity distribution information corresponding to the first type of clinical target as initial radiation field intensity distribution information; A disturbance score determination module is used to determine the disturbance score of each of the N field angles according to the target field intensity distribution information and the initial field intensity distribution information.

6. The device for determining the field angle according to claim 4 or 5, characterized in that: The disturbance score determination module comprises: A first processing submodule, configured to use the field intensity of the kth field angle recorded in the target field intensity distribution information as the first field intensity of the kth field angle, wherein the kth field angle is any field angle in the field set; A second processing submodule is configured to use the field intensity of the kth field angle recorded in the initial field intensity distribution information as the second field intensity of the kth field angle; The third processing submodule is used to determine the disturbance score of the kth field angle according to the first field intensity and the second field intensity of the kth field angle.

7. The device for determining the field angle according to claim 1, characterized in that: The fourth determining subunit includes: A sorting module, used for sorting the N field angles according to the disturbance score of each field angle to obtain a sorting result; A target field angle determination module is used to determine the X target field angles from the N field angles according to the sorting result and the target strategy, wherein the target strategy is used to select the minimum number of field angles when the initial field intensity of the selected field angles can achieve at least one clinical goal among the M clinical goals.

8. A method for determining a field angle, characterized in that: include: Acquire a field set, wherein the field set includes N field angles, wherein N is an integer greater than 1; Set M clinical goals, where M is an integer greater than 1; Determine the field intensity corresponding to each field angle in the field set according to the Lth clinical target, and obtain the field intensity distribution information corresponding to the Lth clinical target, wherein L is a positive integer less than or equal to M; determine X target field angles from the N field angles according to the M field intensity distribution information corresponding to the M clinical targets, wherein X is an integer less than or equal to N and greater than or equal to 1, and the target field angle is the field angle used to formulate a radiotherapy plan; Wherein, determining the field intensity corresponding to each field angle in the field set according to the Lth clinical target, and obtaining the field intensity distribution information corresponding to the Lth clinical target, includes: setting the constraint conditions of the Lth clinical target, wherein the constraint conditions of the Lth clinical target are used to ensure that the calculated radiotherapy dose information can achieve the Lth clinical target; determining the field intensity corresponding to each field angle in the field set according to the constraint conditions of the Lth clinical target, and obtaining the field intensity distribution information corresponding to the Lth clinical target; Determining X target field angles from the N field angles according to the M field intensity distribution information corresponding to the M clinical targets, including: determining a disturbance score for each of the N field angles according to the M field intensity distribution information corresponding to the M clinical targets, wherein the disturbance score for each field angle represents the degree to which the field intensity of each field angle is disturbed during the execution of the radiotherapy plan; and determining X target field angles from the N field angles according to the disturbance score for each of the N field angles.

9. A computer-readable storage medium, characterized in that: The computer-readable storage medium stores a computer program, wherein when the computer program is executed, the device where the computer-readable storage medium is located controls the operation of the device for determining the field angle according to any one of claims 1 to 7.

10. An electronic device, characterized in that: It comprises one or more processors and a memory, wherein the memory is used to store one or more programs, wherein when the one or more programs are executed by the one or more processors, the one or more processors control the operation of the device for determining the field angle as described in any one of claims 1 to 7.

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