Red soothing wash-free gel special for radio frequency beauty instrument and preparation method of red soothing wash-free gel

Abstract

The invention belongs to the technical field of medical or skin care preparations, and discloses a special red soothing wash-free gel for a radio frequency beauty instrument and a preparation method of the gel. 0.1 to 1 part of a sodium hyaluronate cross-linked polymer; 1.5 to 2.5 parts of a soothing active component; 0.08 to 0.16 part of a pH regulator; 12 to 18 parts of a polyol type humectant; 0.2 to 0.4 part of carbomer; 0.2 part of p-hydroxyacetophenone; and the balance of purified water. Wherein the soothing active component is prepared from dipeptide-2 and a purslane herb extract, and the mass ratio of the dipeptide-2 to the purslane herb extract is (1 to 2) to (3 to 2). According to the invention, the skin redness symptom caused by the integration of angiotelectasis and inflammatory reaction in the operation of the radio frequency beauty instrument can be effectively inhibited and relieved, and the gel is prevented from sticking to the skin surface layer.

Description

Technical Field

[0001] This invention belongs to the technical field of medical or skin care products, and more specifically, relates to a soothing, no-rinse gel for radiofrequency beauty devices and its preparation method. Background Technology

[0002] As living standards and economic capacity continue to improve, people's awareness of skin care is gradually increasing, leading to the emergence of a wide variety of beauty devices. Radiofrequency (RF) beauty devices are currently a widely accepted and popular non-invasive beauty treatment. They utilize an RF generator to emit radiofrequency waves that penetrate the user's skin, causing cell molecules to resonate and rotate, generating heat energy. This instantly raises the temperature of the skin's deeper layers, stimulating immediate collagen tightening and promoting collagen regeneration, thus achieving skin tightening, wrinkle reduction, and improved skin laxity. However, while heating local skin tissue, the RF waves emitted by the generator can cause minor skin surface damage and capillary dilation, easily leading to symptoms such as facial redness and a burning sensation.

[0003] Currently, when using radiofrequency (RF) beauty devices for skin care, people usually need to use a special gel in conjunction with the device. This gel helps prevent skin burns caused by concentrated RF energy during the treatment and also helps the RF energy to be better conducted to the deeper layers of the skin. Furthermore, the gel provides lubrication to help the RF device glide across the skin surface, ensuring even distribution of RF energy and improving the beauty effect. However, existing gels are often ineffective in addressing the common problem of facial redness and burning sensations that occur during RF beauty treatments.

[0004] Furthermore, existing gels often adhere to and stick to the skin surface after radiofrequency beauty treatments, resulting in a poor user experience. While prolonged rinsing can remove the gel adhering to the skin surface, it can also disrupt the skin's original mechanisms, causing moisture loss and invisible damage to the skin.

[0005] In view of the above-mentioned defects, it is necessary to provide a soothing, no-rinse gel for radiofrequency beauty devices and its preparation method, so as to effectively solve the technical problems that commonly occur during radiofrequency beauty treatments, such as facial redness, slight damage and burning sensation, as well as the fact that existing gels often adhere to and stick to the skin surface after the radiofrequency beauty treatment, resulting in a poor user experience. Summary of the Invention

[0006] The main objective of this invention is to propose a soothing, no-rinse gel for radiofrequency beauty devices and its preparation method. This invention aims to solve at least one of the technical problems commonly encountered during existing radiofrequency beauty treatments: facial redness, slight damage accompanied by a burning sensation, and the fact that existing gels often adhere to and stick to the skin surface after the radiofrequency beauty treatment, resulting in a poor user experience.

[0007] To achieve the above objectives, in a first aspect, the present invention provides a no-rinse, redness-relieving gel specifically for radiofrequency beauty devices, comprising, in 100 parts by weight: 0.1 to 0.5 parts of sodium hyaluronate; 0.1~1 part of sodium hyaluronate cross-linked polymer; 1.5 to 2.5 parts soothing active ingredients; 0.08~0.16 parts pH adjuster; 12-18 parts of polyol moisturizer; 0.2~0.4 parts carbomer; 0.2 parts p-hydroxyacetophenone; The remainder is purified water; of which, The soothing active ingredient is composed of dipeptide-2 and purslane extract, wherein the mass ratio of dipeptide-2 to purslane extract is 1:2 to 3:2. The electrical conductivity of the gel is 1300~1700µS / cm.

[0008] Preferably, the soothing active ingredients in the gel include 1 part purslane extract.

[0009] Preferably, the pH adjuster is selected from potassium hydroxide or aminomethylpropanol.

[0010] Preferably, the pH adjuster is composed of potassium hydroxide and aminomethylpropanol.

[0011] Preferably, the sodium hyaluronate is selected from at least one of hydrolyzed sodium hyaluronate, low molecular weight sodium hyaluronate, and medium molecular weight sodium hyaluronate.

[0012] Preferably, the molecular weight of the hydrolyzed sodium hyaluronate is 400 Da to 5000 Da.

[0013] Preferably, the molecular weight of the low molecular weight sodium hyaluronate is 20 wDa to 40 wDa.

[0014] Preferably, the molecular weight of the medium molecular weight sodium hyaluronate is 80 wDa to 100 wDa.

[0015] Preferably, the polyol moisturizer is selected from at least one of glycerin, 1,3-propanetriol, butylene glycol, 1,2-pentanediol, 1,2-hexanediol, and trimethylpentanediol / adipic acid / glycerin crosspolymer.

[0016] Secondly, this invention also proposes a method for preparing a no-rinse, redness-relieving gel specifically for radiofrequency beauty devices, the method comprising: Step S1: Weigh out 0.1-0.5 parts of sodium hyaluronate, 0.1-1 parts of sodium hyaluronate crosspolymer, 1.5-2.5 parts of soothing active ingredient, 0.08-0.16 parts of pH adjuster, 12-18 parts of polyol moisturizer, 0.2-0.4 parts of carbomer, 0.2 parts of p-hydroxyacetophenone, and the remainder is purified water, based on a weight of 100 parts. Step S2: Add carbomer, sodium hyaluronate cross-linked polymer, and purified water into the main mixing tank and stir until homogeneous; Step S3: Add polyol moisturizer and sodium hyaluronate to the pre-mixing tank and stir thoroughly until the materials are evenly dispersed; Step S4: Transfer the material in the pre-mixing tank to the main mixing tank, stir and heat to 75~85℃, and disperse the material evenly; Step S5: Cool the main mixing tank and add p-hydroxyacetophenone and pH adjuster into the main mixing tank; Step S6: When the temperature in the main mixing tank drops to 40~45℃, add the soothing active ingredients into the main mixing tank and stir thoroughly to prepare a soothing, no-rinse gel for radiofrequency beauty devices.

[0017] Compared with the prior art, the present invention has the following beneficial effects: 1. The soothing active ingredients in the radiofrequency beauty device-specific redness-relieving no-rinse gel of the present invention are composed of dipeptide-2 and purslane extract. Dipeptide-2 can inhibit angiotensin-converting enzyme ACE, enhance lymphatic circulation, and reduce vascular permeability and vasodilation by inhibiting the activity of bradykinin B2 receptors, thereby reducing the occurrence of vascular hyperresponsiveness. Purslane extract contains flavonoids, phenols, and sterols, which have excellent soothing and anti-inflammatory effects and can effectively reduce skin redness caused by inflammatory reactions. At the same time, the mass ratio of dipeptide-2 to purslane extract is controlled at 1:2 to 3:2. Thus, dipeptide-2 and purslane extract can work synergistically to effectively inhibit and alleviate skin redness caused by capillary dilation and inflammatory reactions during radiofrequency beauty device operation.

[0018] 2. The sodium hyaluronate in the radiofrequency beauty device redness-relieving no-rinse gel of the present invention is selected from at least one of hydrolyzed sodium hyaluronate, low molecular weight sodium hyaluronate, and medium molecular weight sodium hyaluronate, and its molecular weight is set. Compared with high molecular weight sodium hyaluronate, hydrolyzed sodium hyaluronate, low molecular weight sodium hyaluronate, and medium molecular weight sodium hyaluronate are more easily absorbed by the human body into the blood and penetrate into the dermis, thereby effectively reducing the residue of the gel on the skin surface after the radiofrequency beauty operation and preventing the skin from feeling sticky. 3. The sodium hyaluronate cross-linked polymer in the radiofrequency beauty device-specific redness-soothing no-rinse gel of the present invention is an ultra-high molecular weight polymer obtained by cross-linking sodium hyaluronate. It has a dense network structure, which can provide the gel with an appropriate amount of material strength, thereby reducing the use of thickeners and making the skin feel smoother and more elastic. At the same time, the sodium hyaluronate cross-linked polymer can bind more water molecules, forming a long-lasting biological protective film on the skin surface, which can bring a better smoothness, is not sticky after drying, and can effectively fill the gaps and unevenness on the skin surface, so that the radiofrequency energy can be more evenly transmitted to the deep layers of the skin. Attached Figure Description

[0019] Figure 1 This is a schematic diagram illustrating the operation process of preparing a no-rinse, redness-relieving gel for radiofrequency beauty devices according to one embodiment of the present invention.

[0020] Figure 2 This is a line graph showing the rate of change in skin redness immediately (T5min) during the human efficacy test-soothing test of this invention.

[0021] Figure 3 This is a comparison image of the area on the arm where the radiofrequency beauty device was applied (T5min) immediately after a subject used the device in the human efficacy test-soothing test of this invention, under polarized light.

[0022] Figure 4 This is a line graph showing the rate of change in skin redness at T1h during the soothing test of the human efficacy detection of this invention. Detailed Implementation

[0023] The various aspects of the present invention will be further described in detail below.

[0024] Unless otherwise defined or stated, all technical and scientific terms used herein have the same meaning as are familiar to a user skilled in the art. Furthermore, any methods and materials similar to or equivalent to those described herein may be applied to the methods of this invention.

[0025] Unless otherwise expressly specified and limited, the term "or" as used in this invention includes the relationship of "and". "And" is equivalent to the Boolean logic operator "AND", and "or" is equivalent to the Boolean logic operator "OR", with "AND" being a subset of "OR".

[0026] It is understood that although the terms "first," "second," etc., may be used herein to describe different elements, these elements should not be limited by these terms. These terms are merely used to distinguish one element from another. Therefore, a first element can be referred to as a second element without departing from the teachings of this disclosure.

[0027] In this invention, the terms "mainly composed of" and "composed of" are included in the terms "containing", "comprising" or "including".

[0028] Unless otherwise expressly specified and limited, the terms "connected," "linked," and "connected" in this invention should be interpreted broadly. For example, they can refer to a fixed connection, a connection through an intermediate medium, or a connection within two elements or an interaction between two elements. Users of ordinary skill in the art can understand the specific meaning of these terms in this application based on the specific circumstances.

[0029] For example, if an element (or component) is referred to as being on, coupled to, or connected to another element, then the element may be directly formed on, coupled to, or connected to the other element, or there may be one or more intermediate elements between them. Conversely, if the expressions "directly on," "directly coupled to," and "directly connected to" are used herein, then it indicates that there is no intermediate element. Other terms used to describe relationships between elements should be interpreted similarly, such as "between" and "directly between," "attached" and "directly attached," "adjacent" and "directly adjacent," etc.

[0030] Additionally, it should be noted that the terms "front," "rear," "left," "right," "up," and "down" used in the following description refer to directions in the accompanying drawings. The terms "inner" and "outer" refer to directions toward or away from the geometric center of a particular component, respectively. It is understood that these terms are used here to describe the relationship of one element, layer, or region relative to another element, layer, or region, as shown in the accompanying drawings. These terms should also encompass other orientations of the device in addition to those described in the accompanying drawings.

[0031] Other aspects of the invention will be apparent to those skilled in the art from the disclosure herein.

[0032] To more clearly illustrate the technical solutions in the embodiments of this disclosure or the prior art, specific implementation methods of the present invention will be described below with reference to the accompanying drawings. Obviously, the drawings described below are merely some embodiments of the present invention. For users skilled in the art, other drawings and other implementation methods can be obtained based on these drawings without any creative effort.

[0033] It should also be noted that the illustrations provided in the following embodiments are only schematic representations of the basic concept of this disclosure. The drawings only show components relevant to this application and are not drawn according to the actual number, shape, and size of the components in the actual implementation. In the actual implementation, the form, quantity, and proportion of each component can be arbitrarily changed, and the layout of the components may also be more complex. For example, the thickness of the elements in the drawings may be exaggerated for clarity.

[0034] Existing radiofrequency beauty treatments commonly result in facial redness and a burning sensation, and existing gels often adhere to and stick to the skin surface after the procedure, leading to a poor user experience.

[0035] To address the technical problems in the prior art, this invention proposes a no-rinse, redness-relieving gel specifically for radiofrequency beauty devices. The gel, in 100 parts by weight, comprises: 0.1 to 0.5 parts of sodium hyaluronate; 0.1~1 part of sodium hyaluronate cross-linked polymer; 1.5 to 2.5 parts soothing active ingredients; 0.08~0.16 parts pH adjuster; 12-18 parts of polyol moisturizer; 0.2~0.4 parts carbomer; 0.2 parts p-hydroxyacetophenone; The remainder is purified water; of which, The soothing active ingredient is composed of dipeptide-2 and purslane extract, wherein the mass ratio of dipeptide-2 to purslane extract is 1:2 to 3:2. The electrical conductivity of the gel is 1300~1700µS / cm.

[0036] It should be noted that the applicant unexpectedly discovered that adding dipeptide-2 and purslane extract as soothing active ingredients to the gel effectively alleviated skin redness during radiofrequency beauty procedures; further research into its mechanism revealed: On the one hand, the most basic cause of skin redness is the dilation and congestion of small blood vessels or capillaries in the skin. Dipeptide-2 can inhibit angiotensin-converting enzyme ACE, enhance lymphatic circulation, and reduce vascular permeability and vasodilation by inhibiting the activity of bradykinin B2 receptors, thereby reducing the occurrence of increased neurovascular reactivity.

[0037] On the other hand, radiofrequency beauty devices can cause slight damage to the integrity of skin cells during operation, leading to rupture of the cell membrane and release of its contents. This release causes an inflammatory response in surrounding cells, such as redness and swelling of the skin. Purslane extract contains compounds such as flavonoids, phenols, and sterols, which have excellent soothing and anti-inflammatory effects and can effectively reduce redness caused by inflammatory reactions.

[0038] By setting the soothing active ingredients to consist of dipeptide-2 and purslane extract, the dipeptide-2 and purslane extract can work synergistically to continuously reduce skin redness during or after radiofrequency beauty treatments.

[0039] It should be noted that the mass ratio of dipeptide-2 to purslane extract is 1:2 to 3:2. The above ratio is superior to other ratios in both reducing skin redness caused by radiofrequency beauty treatments and providing a lasting soothing effect after radiofrequency beauty treatments.

[0040] It should be noted that sodium hyaluronate cross-linked polymer is an ultra-high molecular weight polymer obtained from sodium hyaluronate through a cross-linking reaction. It possesses a dense network structure, providing the gel with appropriate volume strength, thereby reducing the need for thickeners and resulting in a smoother, more elastic feel on the skin. Sodium hyaluronate cross-linked polymer can bind more water molecules, forming a long-lasting biological protective film on the skin surface, providing superior smoothness, and remaining non-sticky after drying. It can also effectively fill gaps and unevenness on the skin surface, allowing radiofrequency energy to be more evenly transmitted to the deeper layers of the skin.

[0041] It is important to note that controlling the conductivity of a specialized gel used in conjunction with a radiofrequency (RF) beauty device is crucial. The gel's conductivity must be compatible with the power of the RF device. If the gel's conductivity is too high, conductive coupling can easily occur, causing RF energy to concentrate at the electrodes, potentially leading to burns. Conversely, if the conductivity is too low, it will not be compatible with the RF beauty device's power, resulting in poor RF beauty effects. This application uses a pH adjuster to regulate the gel's conductivity, maintaining it at 1300~1700 µS / cm, ensuring beauty effects while preventing safety issues such as burns.

[0042] As a preferred embodiment, the soothing active ingredients in the gel include 1 part purslane extract.

[0043] In a preferred embodiment, the pH adjuster is selected from potassium hydroxide or aminomethylpropanol.

[0044] In a preferred embodiment, the pH adjuster is composed of potassium hydroxide and aminomethylpropanol.

[0045] It should be noted that the pH adjuster used is ionized potassium hydroxide and non-ionized aminomethylpropanol, which can regulate the gel conductivity and keep it within the preferred range of 1300~1700µS / cm, thus balancing cosmetic effects and preventing burns to the user's skin.

[0046] In a preferred embodiment, the sodium hyaluronate is selected from at least one of hydrolyzed sodium hyaluronate, low molecular weight sodium hyaluronate, and medium molecular weight sodium hyaluronate.

[0047] It should be noted that sodium hyaluronate (HA) is a high-molecular-weight acidic mucopolysaccharide composed of repeatedly linked N-acetylglucosamine and D-glucuronic acid disaccharide units. It is widely found in the extracellular matrix of connective tissue cells in animals and humans. It possesses excellent moisturizing properties, promotes epidermal cell proliferation and differentiation, and scavenge free radicals. Furthermore, different molecular weights of sodium hyaluronate act on different sites and have different effects on the skin. High molecular weight sodium hyaluronate acts on the stratum corneum, forming a protective film to lock in moisture; medium molecular weight sodium hyaluronate acts on the granular layer and spinous layer, hydrating and softening the stratum corneum and replenishing hyaluronic acid; low molecular weight sodium hyaluronate promotes skin cell regeneration and repair, accelerates wound healing, increases skin elasticity and firmness, and reduces the appearance of wrinkles and fine lines; hydrolyzed sodium hyaluronate can promote collagen metabolism and circulation, increase skin collagen synthesis, and improve skin texture.

[0048] The applicant discovered that when at least one of hydrolyzed sodium hyaluronate, low molecular weight sodium hyaluronate, and medium molecular weight sodium hyaluronate is used, and its molecular weight is selected within a suitable range, it is more easily absorbed into the bloodstream and penetrates into the dermis compared to high molecular weight sodium hyaluronate. This effectively reduces the residue of the gel on the skin surface after the radiofrequency beauty procedure, resulting in a smooth and moisturized feel on the skin.

[0049] In a preferred embodiment, the molecular weight of the hydrolyzed sodium hyaluronate is 400 Da to 5000 Da.

[0050] In a preferred embodiment, the molecular weight of the low molecular weight sodium hyaluronate is 20 wDa to 40 wDa.

[0051] In a preferred embodiment, the molecular weight of the medium-molecular-weight sodium hyaluronate is 80 wDa to 100 wDa.

[0052] In a preferred embodiment, the polyol moisturizer is selected from at least one of glycerin, 1,3-propanetriol, butylene glycol, 1,2-pentanediol, 1,2-hexanediol, and trimethylpentanediol / adipic acid / glycerin crosspolymer.

[0053] In a preferred embodiment, the gel may further include one or more of 1,2-pentanediol, 1,2-hexanediol, 1,3-propanetriol, and octanoyl hydroxamic acid.

[0054] Secondly, as attached Figure 1 As shown, this invention also proposes a method for preparing a no-rinse, redness-relieving gel specifically for radiofrequency beauty devices, the method comprising: Step S1: Weigh out 0.1-0.5 parts of sodium hyaluronate, 0.1-1 parts of sodium hyaluronate crosspolymer, 1.5-2.5 parts of soothing active ingredient, 0.08-0.16 parts of pH adjuster, 12-18 parts of polyol moisturizer, 0.2-0.4 parts of carbomer, 0.2 parts of p-hydroxyacetophenone, and the remainder is purified water, based on a weight of 100 parts. Step S2: Add carbomer, sodium hyaluronate cross-linked polymer, and purified water into the main mixing tank and stir until homogeneous; Step S3: Add polyol moisturizer and sodium hyaluronate to the pre-mixing tank and stir thoroughly until the materials are evenly dispersed; Step S4: Transfer the material in the pre-mixing tank to the main mixing tank, stir and heat to 75~85℃, and disperse the material evenly; Step S5: Cool the main mixing tank and add p-hydroxyacetophenone and pH adjuster into the main mixing tank; Step S6: When the temperature in the main mixing tank drops to 40~45℃, add the soothing active ingredients into the main mixing tank and stir thoroughly to prepare a soothing, no-rinse gel for radiofrequency beauty devices. Example 1

[0055] The gel conductivity of this embodiment is 1500 µS / cm. The sodium hyaluronate cross-linked polymer was produced by Shandong Tiansheng Biotechnology Co., Ltd., the dipeptide-2 was produced by Zhejiang Paitai Biotechnology Co., Ltd., and the purslane extract was produced by Belamber Biotechnology (Hangzhou) Co., Ltd.

[0056] Step S1: Weigh out 0.25 parts of sodium hyaluronate, 1 part of sodium hyaluronate crosspolymer, 0.5 parts of dipeptide-2, 1 part of purslane extract, 0.12 parts of potassium hydroxide, 15 parts of polyol moisturizer, 0.3 parts of carbomer, 0.2 parts of p-hydroxyacetophenone, and the remainder is purified water, based on 100 parts by weight. Step S2: Add carbomer, sodium hyaluronate cross-linked polymer, and purified water into the main mixing tank and stir until homogeneous; Step S3: Add polyol moisturizer and sodium hyaluronate to the pre-mixing tank and stir thoroughly until the materials are evenly dispersed; Step S4: Transfer the material in the pre-mixing tank to the main mixing tank, stir and heat to 75~85℃, and disperse the material evenly; Step S5: Cool the main mixing tank and add p-hydroxyacetophenone and pH adjuster into the main mixing tank; Step S6: When the temperature in the main mixing tank drops to 40~45℃, add the soothing active ingredients into the main mixing tank, stir thoroughly to prepare a gel for radio frequency beauty devices. Example 2

[0057] The gel conductivity, sodium hyaluronate cross-linked polymer supplier, dipeptide-2 supplier, and purslane extract supplier in this embodiment are the same as in Example 1.

[0058] Step S1: Weigh out 0.25 parts of sodium hyaluronate, 0.5 parts of sodium hyaluronate crosspolymer, 1 part of dipeptide-2, 1 part of purslane extract, 0.12 parts of potassium hydroxide, 15 parts of polyol moisturizer, 0.3 parts of carbomer, 0.2 parts of p-hydroxyacetophenone, and the remainder is purified water, based on 100 parts by weight. Step S2: Add carbomer, sodium hyaluronate cross-linked polymer, and purified water into the main mixing tank and stir until homogeneous; Step S3: Add polyol moisturizer and sodium hyaluronate to the pre-mixing tank and stir thoroughly until the materials are evenly dispersed; Step S4: Transfer the material in the pre-mixing tank to the main mixing tank, stir and heat to 75~85℃, and disperse the material evenly; Step S5: Cool the main mixing tank and add p-hydroxyacetophenone and pH adjuster into the main mixing tank; Step S6: When the temperature in the main mixing tank drops to 40~45℃, add the soothing active ingredients into the main mixing tank, stir thoroughly to prepare a gel for radio frequency beauty devices. Example 3

[0059] The gel conductivity, sodium hyaluronate cross-linking polymer supplier, dipeptide-2 supplier, and purslane extract supplier in this embodiment are the same as in Example 1.

[0060] Step S1: Weigh out 0.25 parts of sodium hyaluronate, 0.5 parts of sodium hyaluronate crosspolymer, 1.5 parts of dipeptide-2, 1 part of purslane extract, 0.12 parts of potassium hydroxide, 15 parts of polyol moisturizer, 0.3 parts of carbomer, 0.2 parts of p-hydroxyacetophenone, and the remainder is purified water, based on a weight of 100 parts. Step S2: Add carbomer, sodium hyaluronate cross-linked polymer, and purified water into the main mixing tank and stir until homogeneous; Step S3: Add polyol moisturizer and sodium hyaluronate to the pre-mixing tank and stir thoroughly until the materials are evenly dispersed; Step S4: Transfer the material in the pre-mixing tank to the main mixing tank, stir and heat to 75~85℃, and disperse the material evenly; Step S5: Cool the main mixing tank and add p-hydroxyacetophenone and pH adjuster into the main mixing tank; Step S6: When the temperature in the main mixing tank drops to 40~45℃, add the soothing active ingredients into the main mixing tank, stir thoroughly to prepare a gel for radio frequency beauty devices.

[0061] Comparative Example 1 The gel conductivity, sodium hyaluronate cross-linking polymer supplier, dipeptide-2 supplier, and purslane extract supplier for this comparative example are the same as in Example 1.

[0062] Step S1: Weigh 0.25 parts of sodium hyaluronate, 0.5 parts of sodium hyaluronate crosspolymer, 0.12 parts of potassium hydroxide, 12 parts of polyol moisturizer, 0.3 parts of carbomer, 0.2 parts of p-hydroxyacetophenone, and the remainder is purified water, based on 100 parts by weight. Step S2: Add carbomer, sodium hyaluronate cross-linked polymer, and purified water into the main mixing tank and stir until homogeneous; Step S3: Add polyol moisturizer and sodium hyaluronate to the pre-mixing tank and stir thoroughly until the materials are evenly dispersed; Step S4: Transfer the material in the pre-mixing tank to the main mixing tank, stir and heat to 75~85℃, and disperse the material evenly; Step S5: Cool the main mixing tank and add p-hydroxyacetophenone and pH adjuster into the main mixing tank to prepare a gel for radio frequency beauty devices.

[0063] Comparative Example 2 The gel conductivity, sodium hyaluronate cross-linking polymer supplier, dipeptide-2 supplier, and purslane extract supplier for this comparative example are the same as in Example 1.

[0064] Step S1: Weigh out 0.25 parts of sodium hyaluronate, 0.5 parts of sodium hyaluronate crosspolymer, 0.1 parts of dipeptide-2, 1 part of purslane extract, 0.12 parts of potassium hydroxide, 15 parts of polyol moisturizer, 0.3 parts of carbomer, 0.2 parts of p-hydroxyacetophenone, and the remainder is purified water, based on a weight of 100 parts. Step S2: Add carbomer, sodium hyaluronate cross-linked polymer, and purified water into the main mixing tank and stir until homogeneous; Step S3: Add polyol moisturizer and sodium hyaluronate to the pre-mixing tank and stir thoroughly until the materials are evenly dispersed; Step S4: Transfer the material in the pre-mixing tank to the main mixing tank, stir and heat to 75~85℃, and disperse the material evenly; Step S5: Cool the main mixing tank and add p-hydroxyacetophenone and pH adjuster into the main mixing tank; Step S6: When the temperature in the main mixing tank drops to 40~45℃, add the soothing active ingredients into the main mixing tank, stir thoroughly to prepare a gel for radio frequency beauty devices.

[0065] Comparative Example 3 The gel conductivity, sodium hyaluronate cross-linking polymer supplier, dipeptide-2 supplier, and purslane extract supplier for this comparative example are the same as in Example 1.

[0066] Step S1: Weigh out 0.25 parts of sodium hyaluronate, 1 part of sodium hyaluronate crosspolymer, 2 parts of dipeptide-2, 1 part of purslane extract, 0.12 parts of potassium hydroxide, 15 parts of polyol moisturizer, 0.3 parts of carbomer, 0.2 parts of p-hydroxyacetophenone, and the remainder is purified water, based on 100 parts by weight. Step S2: Add carbomer, sodium hyaluronate cross-linked polymer, and purified water into the main mixing tank and stir until homogeneous; Step S3: Add polyol moisturizer and sodium hyaluronate to the pre-mixing tank and stir thoroughly until the materials are evenly dispersed; Step S4: Transfer the material in the pre-mixing tank to the main mixing tank, stir and heat to 75~85℃, and disperse the material evenly; Step S5: Cool the main mixing tank and add p-hydroxyacetophenone and pH adjuster into the main mixing tank; Step S6: When the temperature in the main mixing tank drops to 40~45℃, add the soothing active ingredients into the main mixing tank, stir thoroughly to prepare a gel for radio frequency beauty devices.

[0067] Comparative Example 4 The gel conductivity, sodium hyaluronate cross-linking polymer supplier, dipeptide-2 supplier, and purslane extract supplier for this comparative example are the same as in Example 1.

[0068] Step S1: Weigh out 0.25 parts of sodium hyaluronate, 1 part of sodium hyaluronate crosspolymer, 3 parts of dipeptide-2, 1 part of purslane extract, 0.12 parts of potassium hydroxide, 15 parts of polyol moisturizer, 0.3 parts of carbomer, 0.2 parts of p-hydroxyacetophenone, and the remainder is purified water, based on 100 parts by weight. Step S2: Add carbomer, sodium hyaluronate cross-linked polymer, and purified water into the main mixing tank and stir until homogeneous; Step S3: Add polyol moisturizer and sodium hyaluronate to the pre-mixing tank and stir thoroughly until the materials are evenly dispersed; Step S4: Transfer the material in the pre-mixing tank to the main mixing tank, stir and heat to 75~85℃, and disperse the material evenly; Step S5: Cool the main mixing tank and add p-hydroxyacetophenone and pH adjuster into the main mixing tank; Step S6: When the temperature in the main mixing tank drops to 40~45℃, add the soothing active ingredients into the main mixing tank, stir thoroughly to prepare a gel for radio frequency beauty devices.

[0069] Comparative Example 5 The gel conductivity, sodium hyaluronate cross-linking polymer supplier, dipeptide-2 supplier, and purslane extract supplier for this comparative example are the same as in Example 1.

[0070] Step S1: Weigh out 0.25 parts of sodium hyaluronate, 1 part of sodium hyaluronate crosspolymer, 1 part of purslane extract, 0.12 parts of potassium hydroxide, 12 parts of polyol moisturizer, 0.3 parts of carbomer, 0.2 parts of p-hydroxyacetophenone, and the remainder is purified water, based on 100 parts by weight. Step S2: Add carbomer, sodium hyaluronate cross-linked polymer, and purified water into the main mixing tank and stir until homogeneous; Step S3: Add polyol moisturizer and sodium hyaluronate to the pre-mixing tank and stir thoroughly until the materials are evenly dispersed; Step S4: Transfer the material in the pre-mixing tank to the main mixing tank, stir and heat to 75~85℃, and disperse the material evenly; Step S5: Cool the main mixing tank and add p-hydroxyacetophenone and pH adjuster into the main mixing tank; Step S6: When the temperature in the main mixing tank drops to 40~45℃, add the purslane extract into the main mixing tank and stir thoroughly to prepare a gel for radio frequency beauty devices.

[0071] Comparative Example 6 The gel conductivity, sodium hyaluronate cross-linking polymer supplier, dipeptide-2 supplier, and purslane extract supplier for this comparative example are the same as in Example 1.

[0072] Step S1: Weigh out 0.25 parts sodium hyaluronate, 0.12 parts potassium hydroxide, 15 parts polyol moisturizer, 0.5 parts dipeptide-2, 0.3 parts carbomer, 0.2 parts p-hydroxyacetophenone, and the remainder is purified water, based on 100 parts by weight. Step S2: Add carbomer and purified water to the main mixing tank and stir well; Step S3: Add polyol moisturizer and sodium hyaluronate to the pre-mixing tank and stir thoroughly until the materials are evenly dispersed; Step S4: Transfer the material in the pre-mixing tank to the main mixing tank, stir and heat to 75~85℃, and disperse the material evenly; Step S5: Cool the main mixing tank and add p-hydroxyacetophenone and pH adjuster into the main mixing tank; Step S6: When the temperature in the main mixing tank drops to 40~45℃, add dipeptide-2 into the main mixing tank and stir thoroughly to prepare a gel for radio frequency beauty devices.

[0073] Comparative Example 7 The gel conductivity, sodium hyaluronate cross-linking polymer supplier, dipeptide-2 supplier, and purslane extract supplier for this comparative example are the same as in Example 1.

[0074] Step S1: Weigh out 0.25 parts of sodium hyaluronate, 2 parts of sodium hyaluronate crosspolymer, 0.12 parts of potassium hydroxide, 15 parts of polyol moisturizer, 0.5 parts of dipeptide-2, 0.3 parts of carbomer, 0.2 parts of p-hydroxyacetophenone, and the remainder is purified water, based on 100 parts by weight. Step S2: Add carbomer, sodium hyaluronate cross-linked polymer, and purified water into the main mixing tank and stir until homogeneous; Step S3: Add polyol moisturizer and sodium hyaluronate to the pre-mixing tank and stir thoroughly until the materials are evenly dispersed; Step S4: Transfer the material in the pre-mixing tank to the main mixing tank, stir and heat to 75~85℃, and disperse the material evenly; Step S5: Cool the main mixing tank and add p-hydroxyacetophenone and pH adjuster into the main mixing tank; Step S6: When the temperature in the main mixing tank drops to 40~45℃, add dipeptide-2 into the main mixing tank and stir thoroughly to prepare a gel for radio frequency beauty devices.

[0075] 1. Conductivity test Conductivity tests were conducted on Examples 1, 2, 3, Comparative Examples 1, 2, 3, 4, 5, 6, and 7. The conductivity of the samples was tested using a conductivity meter under standard conditions. Each product was tested three times, and the average value was taken. See Table 1.

[0076] Table 1. Conductivity Test Results

[0077] Results: The conductivity of all examples and comparative examples was around 1500µS / cm with an error of 1%. The test results show that all products have the same working efficiency under the radio frequency beauty device, which eliminates the influence of variables for subsequent soothing efficacy experiments.

[0078] 2. Toxicological tests Test samples: Examples 1-3, Comparative Examples 1-7 Test plan: 2.1 Acute eye irritation / corrosion test: Within 24 hours prior to the start of the experiment, both eyes of the selected animals were examined. All animals were free of eye irritation symptoms, corneal defects, and conjunctival damage. During the experiment, 0.1 mL of the test substance was instilled into the conjunctival sac of the left eye of each of the three animals, and the upper and lower eyelids were passively closed for 1 second to prevent loss of the test substance. The right eye was left untreated as a self-control. Eye examinations were performed at 1 hour, 24 hours, 48 ​​hours, 72 hours, and on days 4 and 7 after administration of the test substance. The experiment was terminated if no irritation reaction was observed after 72 hours. After 24 hours of observation and recording, the eyes of all animals were further examined using sodium fluorescein. Scoring was performed according to the scoring criteria in the acute eye irritation / corrosiveness test of the "Cosmetic Safety Technical Specifications" (2015 edition). The intensity of eye irritation caused by the test substance was determined based on the average highest score of the irritation reaction and the recovery time at each observation time point (24 hours, 48 ​​hours, and 72 hours).

[0079] 2.2 Skin irritation / corrosion test: Approximately 24 hours before the experiment, the hair on both sides of the spine on the back of the test animal was removed without damaging the skin, with the hair removal area approximately 3cm × 3cm on both the left and right sides. Approximately 0.5mL of the test substance was applied to the skin on the left side, covering an area of ​​approximately 2.5cm × 2.5cm, once daily for 7 consecutive days. The skin on the right side served as a control. Starting from the second day, hair was removed before each application, and the area was cleaned with a non-irritating solvent to remove any residual test substance. The control and test areas underwent the same treatment. Results were observed after 1 hour, and scoring was performed according to the "Cosmetic Safety Technical Specifications" (2015 edition). After the experiment, the average score for each test animal was calculated daily, and the skin irritation intensity was determined based on the average score.

[0080] Results: Examples 1, 2, 3, 1, 2, 3, 4, 5, 6 and 7 showed no acute eye irritation / corrosion and no skin irritation / corrosion, indicating that the product is safe and mild.

[0081] 3. Human Efficacy Testing - Soothing Test Test samples: Examples 1-3, Comparative Examples 1-5 Test Procedure: Ten subjects were recruited and divided into two groups. Subjects sat still for 30 minutes in an environment with a temperature of 20–22℃ and humidity of 40–60%RH. Testers marked 4cm × 4cm test areas on the inside of each subject's arm, two on each arm, for a total of four areas. Antera3D images of the arm at baseline (T0h) were acquired using a multi-functional skin 3D imaging device. A 0.2g test sample was applied to the test area, followed by gentle massage using a radiofrequency beauty device until the device reached the set temperature. Antera3D images of the arm were acquired immediately after the radiofrequency beauty device automatically stopped (T5min) and 1 hour later (T1h). Skin hemoglobin parameters were analyzed in polarized light mode, and the average value was taken to evaluate the product's soothing efficacy.

[0082] Table 2. Changes in redness before and after radiofrequency cosmetic procedures

[0083] result: Table 2 shows the rate of change in skin redness immediately after use (T5min) of the gel products corresponding to Examples 1-3 and Comparative Examples 1-5 using a radiofrequency beauty device. Comparative Example 1's gel did not contain dipeptide-2 or purslane extract. For Comparative Examples 5, 2, 1, 2, 3, 3, and 4, the purslane extract in the gel was fixed at 1 part by weight using a controlled variable method. The effect of gradually increasing the weight of dipeptide-2 from 0 parts by weight to 3 parts by weight on the rate of change in skin redness immediately (T5min) was investigated. Table 2 shows that the increase in skin redness immediately (T5min) in Examples 1-3 and Comparative Examples 3 and 4 was significantly weaker than that in Comparative Examples 1, 2, and 5. Figure 2 This conclusion is also shown, which mainly illustrates that the dipeptide-2 contained in Examples 1, 2, 3, Comparative Example 3, and Comparative Example 4 is sufficient to inhibit vascular permeability and vasodilation effects, reduce increased neurovascular reactivity, and thus reduce skin redness during the time interval of gentle massage with a radiofrequency beauty device until the device reaches the set temperature and stops.

[0084] See appendix for further details. Figure 2It shows the trend line obtained by polynomial fitting of the skin redness change rate data corresponding to Comparative Examples 1, 5, 2, 1, 2, 3, 3, and 4: y = -0.0002x 5 + 0.0033x 4 - 0.0231x 3 + 0.0643x 2 - 0.0852x + 0.2869. Similarly, the weight ratio of dipeptide-2 to purslane extract used in Examples 1, 2, 3, Comparative Example 3, and Comparative Example 4 corresponds to the lower values ​​of the skin redness change rate data on the trend line.

[0085] Appendix Figure 2 An exemplary comparison of skin images under polarized light immediately (T5 min) after applying the gels corresponding to Example 2 and Comparative Example 1 to a subject is shown to visually demonstrate the differences.

[0086] Table 3. Changes in redness after radiofrequency ablation

[0087] result: Table 3 shows the data on the rate of change of skin redness at T1h, T5min, and T0 after using the radiofrequency beauty device for the gel products corresponding to Examples 1-3 and Comparative Examples 1-5. Among them, the gel in Comparative Example 1 does not contain dipeptide-2 or purslane extract. For Comparative Examples 5, 2, 1, 2, 3, 3, and 4, the purslane extract in the gel was fixed at 1 part by weight using the controlled variable method. The effect of gradually increasing the weight of dipeptide-2 from 0 parts by weight to 3 parts by weight on the rate of change of skin redness at T1h, T5min, and T0 after using the radiofrequency beauty device was investigated.

[0088] Combined with appendix Figure 4It can be seen that, compared to T5min after using the radiofrequency beauty device, Examples 1, 2, 3, Comparative Examples 3, and 4 showed better performance in terms of redness suppression and soothing, indicating that dipeptide-2 and purslane extract played a synergistic role in the above examples and comparative examples. However, as the weight of dipeptide-2 in Comparative Examples 3 and 4 exceeded 1.5 parts by weight, its redness suppression and soothing effects gradually weakened, indicating that the weight of dipeptide-2 was not positively correlated with the overall effect of redness suppression and soothing. In addition, when examining the comparison of T1h to T0 after using the radiofrequency beauty device, only Examples 1, 2, and 3 showed improvement in skin redness compared to T1h to T0, and the improvement effect was significantly better than all comparative examples, indicating that Examples 1-3 can continuously soothe the skin after radiofrequency beauty treatment and improve the skin redness caused by the radiofrequency beauty device.

[0089] No adverse reactions occurred during the test, indicating that the product is safe and mild.

[0090] 4. Consumer Testing Test samples: Example 1, Comparative Example 6, Comparative Example 7.

[0091] Test protocol: Ten subjects were recruited. A 4cm×4cm test area was marked on the inside of the arm. 0.2g of test sample was transferred to the test area and applied using a radiofrequency beauty device until the device reached the set temperature. The test sample was then applied until it was absorbed. The skin feel during and after the test sample was evaluated using a questionnaire with a 15-point scale.

[0092] Table 4 Consumer Test Results

[0093] The corresponding scores of 1-15 for each dimension are: Spreadability: Very difficult to spread → Very easy to spread; Smoothness: Very rough → Very smooth; Comfort level: From very uncomfortable to very comfortable; Absorbability: Very poorly absorbed → Very well absorbed; Stickiness: Very sticky → Very dry; Residual feeling: Very much residue → Almost no residue; Satisfaction level: Very dissatisfied → Very satisfied.

[0094] Results: According to the self-evaluation results of the subjects, both Example 1 and Comparative Example 7 received positive feedback during use. Comparative Example 6 showed poor smoothness and comfort during use, and some subjects reported that the sample had dried out and the radiofrequency device was scratching their skin, indicating that Comparative Example 6 could not be used with the radiofrequency beauty device. Regarding the evaluation dimensions after sample use, Example 1 performed best in the skin feel dimension, exhibiting good absorption, non-sticky after drying, and the highest level of comfort and satisfaction during and after use.

[0095] Based on this invention, those skilled in the art will understand that one aspect described herein can be implemented independently of any other aspect, and two or more of these aspects can be combined in various ways. For example, any number and aspects set forth herein can be used to implement the device and / or practice the method. Furthermore, this device and / or practice the method can be implemented using other structures and / or functionalities besides one or more of the aspects set forth herein.

[0096] It should be noted that the above embodiments can be freely combined as needed. The above description is only a preferred embodiment of the present invention. It should be pointed out that for users of ordinary skills in this field, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

[0097] All documents mentioned in this invention are incorporated herein by reference as if each document were individually incorporated by reference. Furthermore, it should be understood that after reading the foregoing description of this invention, users skilled in the art can make various alterations or modifications to this invention, and these equivalent forms also fall within the scope defined by the appended claims.

Claims

1. A redness-relief, no-wash gel specially designed for radio frequency beauty devices. It is characterized in that Based on 100 parts by weight, the gel comprises: 0.1~0.5 parts of sodium hyaluronate; 0.1~1 part of sodium hyaluronate cross-linked polymer; 1.5~2.5 parts soothing active ingredients; 0.08~0.16 parts of pH adjuster; 12~18 parts of polyol moisturizer; 0.2~0.4 parts of Carbomer; 0.2 parts of p-hydroxyacetophenone; The balance is purified water; The soothing active ingredient is composed of dipeptide-2 and purslane extract, and the mass ratio of dipeptide-2 to purslane extract is 1:2-3:2; The conductivity of the gel is 1300~1700µs / cm.

2. A redness-relieving, wash-free gel for radio frequency beauty instrument according to claim 1, It is characterized in that The soothing active ingredients in the gel include 1 part of purslane extract.

3. The redness-relieving, wash-free gel for radio frequency beauty instrument according to claim 1, It is characterized in that The pH regulator is selected from potassium hydroxide or aminomethyl propanol.

4. The redness-relieving, wash-free gel for radio frequency beauty instrument according to claim 1, It is characterized in that The pH regulator consists of potassium hydroxide and aminomethyl propanol.

5. The redness-relieving, wash-free gel for radio frequency beauty instrument according to claim 1, It is characterized in that The sodium hyaluronate is selected from at least one of hydrolyzed sodium hyaluronate, low-molecular sodium hyaluronate, and medium-molecular sodium hyaluronate.

6. The redness-relieving, wash-free gel for radio frequency beauty instrument according to claim 5, It is characterized in that The molecular weight of the hydrolyzed sodium hyaluronate is 400Da to 5000Da.

7. The redness-relieving, wash-free gel for radio frequency beauty instrument according to claim 5, It is characterized in that The molecular weight of the low molecular weight sodium hyaluronate is 20wDa ~ 40wDa.

8. The redness-relieving, wash-free gel for radio frequency beauty instrument according to claim 5, It is characterized in that The molecular weight of the medium molecular sodium hyaluronate is 80wDa ~100wDa.

9. The redness-relieving, wash-free gel for radio frequency beauty instrument according to claim 1, It is characterized in that The polyol moisturizer is selected from at least one of glycerol, 1,3-propanetriol, butylene glycol, 1,2-pentanediol, 1,2-hexanediol, and trimethylpentanediol / adipic acid / glycerol cross-linked polymer.

10. A method for preparing the redness-relieving, wash-free gel for radio frequency beauty instrument according to any one of claims 1 to 9, wherein the method include: Step S1: Based on 100 parts by weight, weigh 0.1-0.5 parts of sodium hyaluronate, 0.1-1 parts of sodium hyaluronate cross-linked polymer, 1.5-2.5 parts of soothing active ingredients, 0.08-0.16 parts of pH adjusters, 12-18 parts of polyol moisturizers, 0.2-0.4 parts of carbomer, 0.2 parts of p-hydroxyacetophenone, and the balance is purified water; Step S2: Add carbomer, sodium hyaluronate cross-linked polymer and purified water into a main preparation tank and stir evenly; Step S3: Add the polyol moisturizer and sodium hyaluronate into the pre-mixing tank and stir thoroughly until the materials are evenly dispersed; Step S4: transferring the material in the pre-preparation tank to the main preparation tank, stirring and heating to 75-85° C., and making the material dispersed evenly; Step S5: cooling the main preparation tank, and adding p-hydroxyacetophenone and pH adjuster into the main preparation tank; Step S6: When the temperature in the main preparation tank drops to 40-45° C., the soothing active ingredient is added into the main preparation tank and stirred evenly to prepare a redness-relief wash-free gel for radio frequency beauty devices.

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