A liquid medicine mixing device for a perfusion machine

Abstract

The present invention relates to the technical field of pharmaceutical mixing devices, and specifically discloses a liquid medicine mixing device for a filling machine, comprising a frame, a tank body arranged on the frame, a liquid adding tube located at the center of the tank body and penetrating downward into the tank body, a powder adding tube offset to one side of the tank body, a rotary drive mechanism for driving the liquid adding tube to rotate, and a feeding mechanism located in the tank body; the feeding mechanism comprises a cover plate assembly, a sieve plate assembly, and a driving assembly, the cover plate assembly is fixed in the tank body and is provided with a powder inlet; the sieve plate assembly comprises a sieve plate distributed in the air below the cover plate assembly and sleeved on the outside of the liquid adding tube, the sieve plate corresponds to the powder inlet, and the sieve plate and the liquid adding tube are relatively fixed in the circumferential direction and relatively slidably assembled in the vertical direction; the driving assembly comprises an elastic component connected to the sieve plate, a first stop block arranged at the top of the sieve plate assembly, and a second stop block arranged at the bottom of the cover plate assembly. The liquid medicine mixing device for a filling machine realizes a uniform feeding method that can break up lumps.

Description

Technical Field

[0001] The invention relates to the technical field of medicine mixing devices, and in particular to a medicine liquid mixing device for a perfusion machine. Background Art

[0002] The pharmaceutical production process depends on pharmaceutical equipment. The performance and technical level of pharmaceutical equipment directly affect the production capacity and product quality of the enterprise. In pharmaceutical equipment, the filling machine can accurately fill liquid medicine, suspension or semi-solid medicine into the predetermined container to ensure the accurate dosage of medicine in each container. Liquid medicine usually consists of multiple ingredients. Before filling, the weighed active ingredients and excipients need to be dissolved in appropriate solvents and fully mixed to ensure that these ingredients are evenly distributed in the final product and that each dosage unit contains the correct proportion of active ingredients and inactive ingredients.

[0003] A Chinese patent document with authorization announcement number CN220125962U discloses a biopharmaceutical liquid mixing device, which arranges a stirring blade at the bottom of a mixing cylinder, and makes the stirring blade fit with the bottom of the mixing cylinder. Under the operation of a rotating motor, the stirring blade is driven to rotate at high speed, scooping up the solid powder deposited at the bottom and driving it to rotate. At the same time, the stirring rod and the stirring blade rotate in opposite directions, generating reverse water flow, strengthening the impact on the solid powder, accelerating its dissolution, and effectively improving the mixing efficiency.

[0004] However, in the prior art, the above-mentioned biopharmaceutical liquid mixing device directly adds the powder into the mixing cylinder through the feed port when mixing the liquid medicine, which easily leads to uneven distribution of the powder raw materials in the mixing cylinder, affecting the mixing efficiency. In addition, when there are lumps in the powder raw materials, the lumps directly added into the liquid medicine are difficult to disperse quickly, and may form local concentrations during the mixing process, affecting the uniformity of mixing. Summary of the invention

[0005] The invention provides a liquid medicine mixing device for a filling machine, aiming to solve the problems of uneven feeding of raw medicine powder materials in liquid medicine mixing devices for biopharmaceuticals in the related art, and the possibility of directly adding agglomerated powder into liquid medicine, thus affecting mixing efficiency and mixing uniformity.

[0006] The present invention provides a liquid medicine mixing device for a perfusion machine using the following technical solutions:

[0007] A liquid medicine mixing device for a filling machine comprises a frame and a tank body arranged on the frame, and also comprises a liquid adding pipe located at the center of the tank body and penetrating downward into the tank body, a powder adding pipe offset to one side of the tank body, a rotary drive mechanism driving the liquid adding pipe to rotate around an axis extending up and down, and a feeding mechanism located in the tank body; the feeding mechanism comprises a cover plate assembly, a sieve plate assembly, and a driving assembly, the cover plate assembly is fixed in the tank body and is provided with a powder inlet corresponding to the powder adding pipe, and the liquid adding pipe penetrates the cover plate assembly; the sieve plate assembly comprises a sieve plate distributed in the air below the cover plate assembly and sleeved on the outside of the liquid adding pipe, the sieve plate has a supporting surface corresponding to the powder inlet, and the cover plate assembly has a supporting surface corresponding to the supporting surface The parallel and opposite extrusion surfaces, the sieve plate and the liquid adding tube are assembled together in a circumferentially relatively fixed manner and in a vertically relatively sliding manner; the driving assembly includes an elastic component, a first stop block, and a second stop block. The elastic component is connected to the sieve plate to apply an upward elastic force to the sieve plate, the first stop block is arranged at the top of the sieve plate assembly, and the second stop block is arranged at the bottom of the cover plate assembly; when the first stop block rotates with the sieve plate assembly to the second stop block, it is pushed downward by the second stop block to move the sieve plate assembly downward; after the first stop block rotates with the sieve plate assembly and passes over the second stop block, the elastic component pulls the sieve plate assembly upward, so that the extrusion surface of the cover plate assembly cooperates with the sieve plate to squeeze out the lumps in the powder raw materials on the supporting surface.

[0008] By adopting the above technical scheme, a feeding mechanism is arranged in the tank body. When adding materials, the medicine powder raw material is put into the sieve plate in the tank body through the powder adding pipe, and the sieve plate is driven to rotate through the liquid adding pipe, so that the medicine powder raw material is evenly distributed along the circumference of the sieve plate. At the same time, the sieve plate assembly is driven by the driving assembly to move up and down while rotating, so that the sieve plate and the cover plate assembly can squeeze and crush the agglomerated parts in the medicine powder raw material on the sieve plate, and through the up and down vibration of the sieve plate, the powdered medicine powder raw material can pass through the sieve holes on the sieve plate and be evenly sprinkled in the mixed liquid medicine in the tank body; thus, by setting up the feeding mechanism, a uniform feeding method that can break up the agglomerates of the raw materials is realized, which helps the medicine powder raw material to be better dispersed in the mixed liquid medicine, which is beneficial to improving production efficiency and mixing uniformity.

[0009] Furthermore, the elastic component includes a connecting ring rotatably mounted at the center of the sieve plate, and a spring connected between the cover plate assembly and the connecting ring. The connecting ring and the sieve plate are relatively fixedly assembled together in the up and down directions.

[0010] Furthermore, the center position of the cover plate assembly has an installation cavity extending up and down and corresponding to the upper and lower parts of the connecting ring, and the spring is located in the installation cavity.

[0011] Furthermore, the first stop block is in a semi-cylindrical shape, the second stop block is in an arc-shaped plate shape, and the end surfaces of both ends of the second stop block in the length direction are curved surfaces.

[0012] Furthermore, a first annular gap is provided between the outer peripheral side of the sieve plate and the inner wall of the tank body, and the sieve plate assembly also includes a rotating ring located above the first annular gap and a material shifting piece connected between the sieve plate and the rotating ring; the cover plate assembly includes a cover plate, a fixing ring, and a connecting piece connected between the cover plate and the fixing ring, a second annular gap matched with the rotating ring is provided between the outer peripheral side of the cover plate and the inner wall of the tank body, and the fixing ring is located above the second annular gap.

[0013] By adopting the above technical solution, the rotating ring can enter the second annular gap and seal the second annular gap. At this time, the rotating ring cooperates with the cover plate, which is beneficial to reduce the splashing of the powder raw material.

[0014] Furthermore, the liquid adding tube is assembled on the tank body for movement up and down, and the filling machine liquid medicine mixing device also includes a stirring mechanism located in the tank body and arranged at the lower end of the liquid adding tube, the stirring mechanism includes a main stirring member and a scraper ring, the main stirring member is fixed to the lower end of the liquid adding tube, the outer peripheral side of the main stirring member is connected to the scraper ring and drives the scraper ring to move up and down, the outer peripheral side of the scraper ring is in contact with the inner wall of the tank body, so that the agglomerated medicine attached to the inner wall of the tank body can be scraped to the upper surface of the scraper ring when the scraper ring moves up, and the scraper ring can move up to the first annular gap, so that the material stripping sheet guides the agglomerated medicine on the upper surface of the scraper ring to move onto the screen plate.

[0015] Furthermore, the stirring mechanism further comprises auxiliary stirring members, a plurality of the auxiliary stirring members are arranged on the lower surface of the scraper ring, and the auxiliary stirring members are flush with the lower surface of the main stirring member.

[0016] By adopting the above technical solution, the auxiliary stirring element can cooperate with the main stirring element to cover all areas in the tank body, avoiding the occurrence of mixing dead corners that cause high or low concentrations in local areas of the tank body, affecting the uniformity of the mixture, and ensuring the mixing effect.

[0017] Furthermore, the stirring mechanism also includes gears and a gear ring, the main stirring element includes a main stirring shaft fixed to the lower end of the liquid adding tube, and a plurality of main stirring blades fixed on the main stirring shaft, each of the main stirring blades has an inclination angle with the inner bottom surface of the tank body, the outer ends of the plurality of main stirring blades are respectively fixed to the inner circumference of the gear ring, and the gear ring is rotatably installed on the scraper ring, the auxiliary stirring element includes an auxiliary stirring shaft, and a plurality of auxiliary stirring blades fixed on the auxiliary stirring shaft, each of the auxiliary stirring blades is perpendicular to the bottom surface of the tank body, and the upper end of the auxiliary stirring shaft extends into the scraper ring and is equipped with a gear meshing with the gear ring.

[0018] By adopting the above technical solution, the main stirring blade is set as an inclined blade paddle. Under the push of the main stirring blade, the mixed liquid medicine in the tank body not only moves along the axial direction of the main stirring shaft, but also diffuses to the surrounding areas of the tank body, which can provide higher stirring efficiency and accelerate the mixing speed of the liquid medicine and the powder raw materials; the auxiliary stirring blade is set as a straight blade paddle. Under the push of the auxiliary stirring blade, the mixed liquid medicine around the tank body can flow into the tank body, which is beneficial to improve the fluidity at the inner wall of the tank body and optimize the mixing effect; thereby, the coverage area, setting number and shape of the stirring blade are optimized to achieve the best stirring effect and ensure that the liquid medicine and the powder raw materials can be fully mixed.

[0019] Furthermore, the liquid adding pipe is provided with a liquid spraying port above the main stirring member, and a plurality of the liquid spraying ports are evenly arranged along the circumference of the liquid adding pipe. The liquid adding pipe can be moved upward until the liquid spraying port is located between the sieve plate and the cover plate.

[0020] By adopting the above technical scheme, the liquid spray port is arranged above the main stirring member, which is beneficial for the liquid medicine flowing out of the liquid spray port to contact with the main stirring member as soon as possible, and to be mixed with other raw materials in the tank body under the stirring action of the main stirring member, so as to improve the mixing efficiency; when the liquid adding pipe moves up to the liquid spray port and is located between the sieve plate and the cover plate, the liquid medicine sprayed from the liquid spray port can also rinse the small amount of powdered raw materials remaining on the sieve plate, so as to improve the accuracy of the liquid medicine mixing and improve the quality of the medicine.

[0021] Furthermore, the liquid medicine mixing device of the perfusion machine also includes a linear drive component installed on the frame, and the output end of the linear drive component is connected to the liquid adding tube to drive the liquid adding tube to move up and down.

[0022] The beneficial effects of the liquid medicine mixing device of a filling machine provided by the present invention are as follows: a feeding mechanism and a stirring mechanism are arranged in the tank body; when adding materials, the medicine powder raw material is put into the sieve plate in the tank body through the powder adding tube, and the sieve plate is driven to rotate through the liquid adding tube, so that the medicine powder raw material is evenly distributed along the circumference of the sieve plate, and at the same time, the sieve plate assembly is driven by the driving assembly to move up and down while rotating, so that the sieve plate and the cover plate assembly can squeeze and crush the agglomerated parts of the medicine powder raw material on the sieve plate, and through the up and down vibration of the sieve plate, the powdered medicine powder raw material can pass through the sieve holes on the sieve plate and be evenly sprinkled in the mixed medicine liquid in the tank body; thus, by arranging the feeding mechanism, a feeding method that is uniform and can break up the agglomerates of the raw materials is realized, which helps the medicine powder The raw materials are better dispersed in the mixed medicine liquid, which is beneficial to improving production efficiency and mixing uniformity; after mixing for a period of time, the main stirring member and the scraper ring are driven to move upward through the liquid adding tube, so that the scraper ring scrapes the agglomerated medicine attached to the inner wall of the tank body to the upper surface of the scraper ring, and controls the scraper ring to move up to the first annular gap. At this time, the material-shifting piece can guide the agglomerated medicine on the upper surface of the scraper ring to move to the sieve plate, so that it can be broken and sprinkled by the up and down movement of the sieve plate. Therefore, by setting up a stirring mechanism, the scraping of the medicine attached to the inner wall of the tank body is realized, and the scraped agglomerated medicine is broken in cooperation with the feeding mechanism, so that the scraped agglomerated medicine can be fully and effectively mixed in the tank body, thereby ensuring the consistency of the efficacy in the mixed medicine liquid and improving the product quality. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 It is a first structural schematic diagram of the liquid medicine mixing device of the perfusion machine of the present invention.

[0024] Figure 2 It is a second structural schematic diagram of the liquid medicine mixing device of the perfusion machine of the present invention.

[0025] Figure 3 It is a structural schematic diagram of a feeding mechanism and a stirring mechanism of a liquid medicine mixing device for a perfusion machine of the present invention.

[0026] Figure 4 It is a structural schematic diagram of a cover plate assembly of a liquid medicine mixing device for a filling machine of the present invention.

[0027] Figure 5 It is a structural schematic diagram of a sieve plate assembly of a liquid medicine mixing device of a perfusion machine of the present invention.

[0028] Reference numerals:

[0029] 10. Tank body; 100. Frame; 110. Powder adding pipe; 120. Filling head; 20. Liquid adding pipe; 210. Liquid spray port; 220. Motor; 230. Linear drive member; 30. Fixed ring; 310. Second stop block; 320. Connecting member; 40. Cover plate; 410. Powder inlet; 420. Mounting cavity; 50. Rotating ring; 510. First stop block; 520. Material shifting piece; 60. Screen plate; 610. Connecting ring; 620. Spring; 70. Main stirring member; 710. Main stirring shaft; 720. Main stirring blade; 80. Scraper ring; 810. Gear ring; 820. Gear; 90. Auxiliary stirring member; 910. Auxiliary stirring shaft; 920. Auxiliary stirring blade. DETAILED DESCRIPTION

[0030] Embodiments of the present invention are described in detail below, and examples of the embodiments are shown in the accompanying drawings. The embodiments described below with reference to the accompanying drawings are exemplary and intended to be used to explain the present invention, but should not be understood as limiting the present invention.

[0031] Combine the following Figures 1 to 5 The present invention describes a liquid medicine mixing device for a perfusion machine.

[0032] like Figures 1 to 5 As shown, an embodiment of the liquid medicine mixing device for a filling machine of the present invention comprises a frame 100, a tank body 10, a filling head 120, a liquid adding pipe 20, a powder adding pipe 110, a rotary drive mechanism, a linear drive member 230, a feeding mechanism and a stirring mechanism. The tank body 10, the rotary drive mechanism and the linear drive member 230 are respectively arranged on the frame 100, the liquid adding pipe 20 and the powder adding pipe 110 are respectively arranged on the tank body 10 and penetrate downward into the tank body 10, the filling head 120 is arranged at the bottom of the tank body 10, a filling valve is arranged on the filling head 120, and the feeding mechanism and the stirring mechanism are respectively arranged in the tank body 10.

[0033] like Figures 1 to 3As shown, the liquid adding pipe 20 is located at the center of the tank body 10 and is assembled on the tank body 10 so as to move up and down. The upper end of the liquid adding pipe 20 is connected to the outside. The lower part of the liquid adding pipe 20 is provided with a liquid spraying port 210 and penetrates downward into the tank body 10. A plurality of liquid spraying ports 210 are evenly arranged along the circumference of the liquid adding pipe 20 for injecting liquid medicine into the tank body 10. The rotary drive mechanism includes a motor 220, a driving wheel, a transmission belt and a driven wheel. The output end of the motor 220 is connected to the driving wheel to drive the driving wheel to rotate. The driven wheel and the liquid adding pipe 20 are assembled together so as to be relatively fixed in the circumferential direction and relatively slidable in the vertical direction. The driving wheel and the driven wheel are connected through a transmission belt. When the motor 220 drives the driving wheel to rotate, the driving wheel drives the driven wheel to rotate through the transmission belt, and the driven wheel drives the liquid adding pipe 20 to rotate around an axis extending up and down. The output end of the linear drive 230 is connected to the liquid adding pipe 20 to drive the liquid adding pipe 20 to move up and down. The linear drive 230 is a hydraulic cylinder. In other embodiments, the linear drive 230 can also be a cylinder or an electric push rod. The powder adding pipe 110 is fixed to one side of the tank body 10 with an offset. The upper end of the powder adding pipe 110 is connected to the outside world, and the lower end of the powder adding pipe 110 penetrates downward into the tank body 10 for feeding the medicine powder raw material into the tank body 10.

[0034] like Figures 2 to 5 As shown, the feeding mechanism includes a cover plate assembly, a screen plate assembly and a driving assembly for driving the screen plate assembly to move up and down, which are arranged in sequence, and the liquid adding pipe 20 passes through the cover plate assembly.

[0035] The cover plate assembly includes a fixing ring 30, a cover plate 40, and a connector 320 connected between the fixing ring 30 and the cover plate 40. The outer peripheral side of the fixing ring 30 is fixed to the inner wall of the tank body 10, and the cover plate 40 is distributed below the fixing ring 30 in the air. A powder inlet 410 corresponding to the powder adding tube 110 is provided on the cover plate 40. The lower surface of the cover plate 40 forms a horizontally distributed extrusion surface, and the central position of the cover plate 40 forms an installation cavity 420 extending up and down. There is a second annular gap between the outer peripheral side of the cover plate 40 and the inner wall of the tank body 10. The fixing ring 30 is distributed just above the second annular gap. The inner peripheral side of the fixing ring 30 is fixedly connected to the outer peripheral side of the cover plate 40 through the connector 320 to fix the cover plate 40 in the tank body 10.

[0036] The sieve plate assembly includes a rotating ring 50, a sieve plate 60, and a material-shifting sheet 520 connected between the rotating ring 50 and the sieve plate 60. The sieve plate 60 is distributed below the cover plate 40 and is sleeved on the outside of the liquid-adding tube 20. The sieve plate 60 and the liquid-adding tube 20 are relatively fixed in the circumferential direction and relatively slidably assembled together in the vertical direction. The upper surface of the sieve plate 60 forms a horizontally distributed supporting surface opposite to the extrusion surface. The sieve plate 60 in the embodiment is provided with a perforation in the center, which is used to install the liquid-adding tube 20. The side wall of the perforation is provided with a vertical groove connected to the liquid-adding tube 20 for vertical sliding. There is a first annular gap between the outer peripheral side of the sieve plate 60 and the inner wall of the tank body 10. The rotating ring 50 is distributed directly above the first annular gap and can enter the second annular gap to block the second annular gap. At this time, the rotating ring 50 cooperates with the cover plate 40, which is conducive to reducing the splashing of the powder raw material. A plurality of material-shifting pieces 520 are fixed to the lower surface of the rotating ring 50, and the plurality of material-shifting pieces 520 are fixedly connected to the outer peripheral side of the sieve plate 60. When the material-shifting pieces 520 rotate with the rotating ring 50, they can push the medicine powder material on the upper surface of the scraper ring 80 to move toward the sieve plate 60. The material-shifting pieces 520 in the embodiment are arc-shaped, and the arc-shaped design can reduce the friction and resistance of the medicine powder material during the movement process, thereby improving the flow efficiency. The lower surface of the material-shifting piece 520 is flush with the upper surface of the sieve plate 60.

[0037] The driving assembly includes an elastic component, a first stop block 510 , and a second stop block 310 .

[0038] The elastic component includes a connecting ring 610 rotatably mounted at the center of the sieve plate 60, and a spring 620 connected between the cover plate assembly and the connecting ring 610. The cross section of the connecting ring 610 is narrow at the top and wide at the bottom, and the sieve plate 60 has an annular groove for mounting the connecting ring 610, so as to realize the rotatable connection and synchronous up and down movement of the connecting ring 610 and the sieve plate 60. The spring 620 is located in the mounting cavity 420, the upper end of the spring 620 is fixed to the cover plate 40, and the lower end of the spring 620 is fixed to the connecting ring 610. The spring 620 is used to apply an upward elastic force to the sieve plate 60 to move the sieve plate 60 upward and close to the cover plate 40, so that the sieve plate 60 and the cover plate 40 cooperate to squeeze and crush the powder raw materials on the sieve plate 60, and the agglomerated part of the powder raw materials on the sieve plate 60 is crushed to prevent it from forming a block on the sieve plate 60 or falling into the tank body 10 to affect the mixing effect. Furthermore, in other embodiments, the elastic component may only include a spring 620 , and the spring 620 is connected between the liquid adding pipe 20 and the screen plate 60 .

[0039] A plurality of second stops 310 are fixed to the lower surface of the fixed ring 30 along the circumference of the fixed ring 30. Each second stop 310 is in the shape of an arc plate, and the end faces of the second stops 310 at both ends in the length direction are curved surfaces. A plurality of first stops 510 are fixed to the upper surface of the rotating ring 50 along the circumference of the rotating ring 50. Each first stop 510 is in the shape of a semi-cylinder. When the first stop 510 rotates with the sieve plate assembly to the second stop 310, it is pushed downward by the second stop 310 to move the sieve plate assembly downward, and the sieve plate 60 is vibrated up and down in cooperation with the elastic force of the spring 620, so as to sieve the powder raw materials on the sieve plate 60, so that the powdered drugs pass through the sieve holes on the sieve plate 60 and are evenly sprinkled in the mixed liquid medicine in the tank body 10, while the sieved agglomerated drugs remain on the sieve plate 60. The parallel and opposite extrusion surfaces and support surfaces can sieve the drugs that fail to pass through the sieve plate 60. The lumps in the sieve holes are broken up. Since the distance between the extrusion surface and the supporting surface is the same at any two points, it can ensure that the pressure applied by the extrusion surface and the supporting surface on the agglomerated powder is uniform, which is beneficial to improving the breaking efficiency, thereby preventing the agglomerated powder from falling directly into the medicine liquid and affecting the mixing efficiency and mixing uniformity. At the same time, it also avoids the problem that the agglomerated powder may clog the sieve holes and affect the feeding efficiency of the sieve plate 60, requiring manual disassembly, cleaning and unblocking of the sieve plate 60, thereby realizing a uniform feeding method that can break up the agglomerations of raw materials, helping the powder raw materials to be better dispersed in the mixed medicine liquid, which is beneficial to improving production efficiency and mixing uniformity.

[0040] like Figure 2 , Figure 3 and Figure 5 As shown, the stirring mechanism includes a main stirring member 70 , a scraper ring 80 , a gear ring 810 , a gear 820 and an auxiliary stirring member 90 .

[0041] The main stirring member 70 is fixed to the lower end of the liquid adding tube 20 so as to rotate and move up and down with the liquid adding tube 20. The liquid spraying port 210 is located above the main stirring member 70, which is conducive to the liquid medicine flowing out of the liquid spraying port 210 to contact the main stirring member 70 as soon as possible, and to complete mixing with other raw materials in the tank body 10 under the stirring action of the main stirring member 70, so as to improve the mixing efficiency. The main stirring member 70 includes a main stirring shaft 710 and four main stirring blades 720, the main stirring shaft 710 is fixed to the lower end of the liquid adding tube 20, and the four main stirring blades 720 are fixed to the outer peripheral side of the main stirring shaft 710, and each main stirring blade 720 has a certain inclination angle with the bottom surface of the tank body 10. Under the push of the main stirring blades 720, the mixed liquid medicine in the tank body 10 not only moves along the axial direction of the main stirring shaft 710, but also spreads to the surroundings of the tank body 10, which can provide higher stirring efficiency and accelerate the mixing speed of the liquid medicine and the powder raw materials. The outer ends of the four main stirring blades 720 are respectively fixed to the inner circumference of the gear ring 810, and the gear ring 810 is rotatably installed on the scraper ring 80, so that the main stirring blades 720 can drive the gear ring 810 to rotate when the liquid adding tube 20 rotates, and can drive the scraper ring 80 to move up and down when the main stirring blades 720 move up and down with the liquid adding tube 20.

[0042] A plurality of auxiliary stirring members 90 are arranged on the lower surface of the scraper ring 80, and the auxiliary stirring members 90 are flush with the lower surface of the main stirring member 70. Thus, the auxiliary stirring members 90 can cooperate with the main stirring member 70 to cover all areas inside the tank body 10, avoiding the occurrence of mixing dead corners that cause higher or lower concentrations in local areas of the tank body 10, affecting the uniformity of the mixture, and ensuring the mixing effect.

[0043] Each auxiliary stirring member 90 includes an auxiliary stirring shaft 910 and four auxiliary stirring blades 920. The upper end of the auxiliary stirring shaft 910 extends into the scraper ring 80 and is equipped with a gear 820 meshing with the gear ring 810. The scraper ring 80 has a cavity for installing the gear 820. The four auxiliary stirring blades 920 are fixed to the outer peripheral side of the auxiliary stirring shaft 910 and are located below the scraper ring 80, so that when the gear ring 810 rotates, it can drive the auxiliary stirring shaft 910 and the auxiliary stirring blades 920 to rotate by meshing with the gear 820. Each auxiliary stirring blade 920 is perpendicular to the bottom surface of the tank body 10. Under the push of the auxiliary stirring blades 920, the mixed liquid around the tank body 10 can flow into the tank body 10, which is conducive to improving the fluidity at the inner wall of the tank body 10 and optimizing the mixing effect.

[0044] The outer peripheral side of the scraper ring 80 is fitted with the inner wall of the tank body 10 so that the agglomerated drugs attached to the inner wall of the tank body 10 can be scraped to the upper surface of the scraper ring 80 when the scraper ring 80 moves upward. The scraper ring 80 can move upward to abut against the lower surface of the stripper piece 520. At this time, the scraper ring 80 is located in the first annular gap, and the upper surface of the scraper ring 80 is flush with the upper surface of the sieve plate 60. The stripper piece 520 rotates around the central axis of the tank body 10 driven by the sieve plate 60 to push and guide the agglomerated drugs on the upper surface of the scraper ring 80 to move onto the sieve plate 60, and then the sieve plate 60 is vibrated up and down to break and sprinkle it, so that the scraped agglomerated drugs can be fully and effectively mixed in the tank body 10, thereby ensuring the consistency of the efficacy of the mixed medicine and improving the product quality.

[0045] The working process of the embodiment of the liquid medicine mixing device for a perfusion machine of the present invention comprises the following steps:

[0046] The first step is to add liquid and powder. The linear drive 230 and the motor 220 are started. The linear drive 230 controls the liquid adding tube 20 to move down to the bottom of the tank body 10. According to the formula requirements of the medicine, the medicine liquid is introduced into the liquid adding tube 20, and the medicine liquid enters the tank body 10 through the liquid spray port 210. The medicine powder raw materials are introduced into the powder adding tube 110, and the medicine powder raw materials enter the tank body 10 through the lower end of the powder adding tube 110. The motor 220 drives the liquid adding tube 20 to rotate.

[0047] The second step is sieving and crushing. The liquid adding pipe 20 drives the sieve plate 60 to rotate around the axis of the liquid adding pipe 20, so that the powder raw materials falling on the sieve plate 60 through the powder inlet 410 are evenly distributed along the circumference of the sieve plate 60; the sieve plate 60 drives the rotating ring 50 and the first stop block 510 and the material-pickup sheet 520 located on the rotating ring 50 to rotate around the axis of the liquid adding pipe 20, and the spring 620 applies an upward elastic force to the sieve plate 60 to move the sieve plate 60 up and close to the cover plate 40, and the second stop block 310 The first stop block 510 can be pushed against to cooperate with the elastic force of the spring 620 to make the sieve plate 60 vibrate up and down, and the powdered medicine material on the supporting surface of the sieve plate 60 can be screened. The powdered medicine can pass through the sieve holes on the sieve plate 60 and evenly fall into the mixed medicine liquid in the tank body 10. The screened agglomerated medicine remains on the sieve plate 60, is squeezed and crushed into powder by the sieve plate 60 and the cover plate 40, and then falls into the mixed medicine liquid in the tank body 10 through the sieve holes on the sieve plate 60.

[0048] In the third step, at the initial stage of mixing, the liquid adding tube 20 drives the main stirring member 70 to rotate around the axis of the liquid adding tube 20, and the main stirring member 70 drives the auxiliary stirring member 90 to rotate through the meshing of the gear 820 and the gear ring 810 to stir and mix the liquid and powder raw materials.

[0049] The fourth step is the later stage of mixing. After a period of mixing, the linear drive member 230 controls the liquid adding tube 20 to move upward, and the upward movement of the liquid adding tube 20 drives the scraper ring 80 to move upward. The scraper ring 80 scrapes the agglomerated drugs attached to the inner wall of the tank body 10 to the upper surface of the scraper ring 80 until the upper surface of the scraper ring 80 abuts against the lower surface of the material-dispensing sheet 520. At this time, the scraper ring 80 is located in the first annular gap, and the upper surface of the scraper ring 80 is flush with the upper surface of the sieve plate 60. The rotating material-push piece 520 pushes and guides the agglomerated medicine on the upper surface of the scraper ring 80 to move onto the sieve plate 60, and then the agglomerated medicine is broken and scattered through the up and down vibration of the sieve plate 60; at the same time, the liquid spray port 210 of the liquid adding pipe 20 moves to between the sieve plate 60 and the cover plate 40, and the remaining liquid medicine is introduced into the liquid adding pipe 20. The liquid medicine is sprayed onto the sieve plate 60 through the liquid spray port 210 to rinse the small amount of powdered medicine raw material remaining on the sieve plate 60.

[0050] The fifth step is filling and sealing. The filling valve on the filling head 120 is opened, and the mixed liquid medicine is filled into the container through the filling head 120, and the container is sealed and packaged.

[0051] In this way, the liquid medicine mixing device of the filling machine is provided with a feeding mechanism and a stirring mechanism in the tank body 10; when adding materials, the powder raw materials are put into the sieve plate 60 in the tank body 10 through the powder adding pipe 110, and the sieve plate 60 is driven to rotate through the liquid adding pipe 20, so that the powder raw materials are evenly distributed along the circumference of the sieve plate 60, and at the same time, the elastic force of the spring 620 and the push of the first stop block 510 and the second stop block 310 make the sieve plate 60 vibrate up and down, and when the sieve plate 60 vibrates upward, it can cooperate with the cover plate 40 to break up the agglomerated parts of the powder raw materials on the sieve plate 60, and through the up and down vibration of the sieve plate 60, the powdered powder raw materials pass through the sieve holes on the sieve plate 60 and are evenly sprinkled in the mixed liquid medicine in the tank body 10; thus, by setting up the feeding mechanism, a uniform feeding method that can break up the agglomerates of the raw materials is realized. , helping the powder raw materials to be better dispersed in the mixed liquid medicine, which is beneficial to improving production efficiency and mixing uniformity; after mixing for a period of time, the main stirring member 70 and the scraper ring 80 are driven to move upward through the liquid adding pipe 20, so that the scraper ring 80 scrapes the agglomerated drugs attached to the inner wall of the tank body 10 to the upper surface of the scraper ring 80, and controls the scraper ring 80 to move up to the first annular gap, at this time, the material-pickling piece 520 can guide the agglomerated drugs on the upper surface of the scraper ring 80 to move to the sieve plate 60, so as to break and sprinkle them through the up and down vibration of the sieve plate 60; thus, by setting up the stirring mechanism, the scraping of the drugs attached to the inner wall of the tank body 10 is realized, and the scraped agglomerated drugs are broken in cooperation with the feeding mechanism, so that the scraped agglomerated drugs can be fully and effectively mixed in the tank body 10, ensuring the consistency of the efficacy in the mixed liquid medicine and improving the product quality.

[0052] In other embodiments of the liquid mixing device for a perfusion machine of the present invention, the stirring mechanism at the bottom can be removed, and only stirring blades are provided on the liquid adding tube 20. In this case, the liquid adding tube 20 can rotate but cannot move up and down. In this case, the sieve plate assembly and the cover plate assembly can be flat plates at the same level.

[0053] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the present invention.

[0054] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In the description of the present invention, the meaning of "plurality" is at least two, such as two, three, etc., unless otherwise clearly and specifically defined.

[0055] Although the embodiments of the present invention have been shown and described above, it is to be understood that the above embodiments are exemplary and are not to be construed as limitations of the present invention. A person skilled in the art may change, modify, replace and vary the above embodiments within the scope of the present invention.

Claims

1. A liquid medicine mixing device for a filling machine, comprising a frame and a tank body arranged on the frame, characterized in that: The invention also includes a liquid adding pipe located at the center of the tank body and penetrating downward into the tank body, a powder adding pipe offset to one side of the tank body, a rotary drive mechanism driving the liquid adding pipe to rotate around an axis extending up and down, and a feeding mechanism located in the tank body; The feeding mechanism includes a cover plate assembly, a screen plate assembly, and a driving assembly. The cover plate assembly is fixed in the tank body and is provided with a powder inlet corresponding to the powder adding tube, and the liquid adding tube runs through the cover plate assembly; the screen plate assembly includes a screen plate distributed in the air below the cover plate assembly and sleeved on the outside of the liquid adding tube, the screen plate has a supporting surface corresponding to the powder inlet, the cover plate assembly has an extrusion surface parallel to the supporting surface, and the screen plate and the liquid adding tube are assembled together so as to be relatively fixed in the circumferential direction and relatively slidable in the up and down directions; the driving assembly includes an elastic component, a first stop block, and a second stop block. The elastic component is connected to the screen plate to apply an upward elastic force to the screen plate, the first stop block is arranged at the top of the screen plate assembly, and the second stop block is arranged at the bottom of the cover plate assembly; when the first stop block rotates with the screen plate assembly to the second stop block, it is pushed downward by the second stop block to move the screen plate assembly downward; after the first stop block rotates with the screen plate assembly and passes over the second stop block, the elastic component pulls the screen plate assembly upward, so that the extrusion surface of the cover plate assembly cooperates with the screen plate to squeeze out the lumps in the medicinal powder raw material on the supporting surface; The elastic component includes a connecting ring rotatably mounted at the center of the sieve plate, and a spring connected between the cover plate assembly and the connecting ring. The connecting ring and the sieve plate are relatively fixedly assembled together in the up and down directions. The center of the cover plate assembly has an installation cavity extending up and down and corresponding to the upper and lower parts of the connecting ring, and the spring is located in the installation cavity; The first stopper is in a semi-cylindrical shape, the second stopper is in an arc-shaped plate shape, and the end surfaces of both ends of the second stopper in the length direction are curved surfaces; There is a first annular gap between the outer peripheral side of the sieve plate and the inner wall of the tank body, and the sieve plate assembly also includes a rotating ring located above the first annular gap and a material shifting sheet connected between the sieve plate and the rotating ring; The cover plate assembly includes a cover plate, a fixing ring, and a connector connected between the cover plate and the fixing ring. A second annular gap matching the rotating ring is provided between the outer peripheral side of the cover plate and the inner wall of the tank body, and the fixing ring is located above the second annular gap.

2. The liquid medicine mixing device for a perfusion machine according to claim 1, characterized in that: The liquid adding tube is assembled on the tank body for movement up and down. The medicine-liquid mixing device of the filling machine also includes a stirring mechanism located in the tank body and arranged at the lower end of the liquid adding tube. The stirring mechanism includes a main stirring member and a scraper ring. The main stirring member is fixed to the lower end of the liquid adding tube. The outer peripheral side of the main stirring member is connected to the scraper ring and drives the scraper ring to move up and down. The outer peripheral side of the scraper ring fits against the inner wall of the tank body to scrape the agglomerated medicine attached to the inner wall of the tank body to the upper surface of the scraper ring when the scraper ring moves up. The scraper ring can move up to the first annular gap so that the material stripping sheet guides the agglomerated medicine on the upper surface of the scraper ring to move to the screen plate.

3. The liquid medicine mixing device for a perfusion machine according to claim 2, characterized in that: The stirring mechanism also includes auxiliary stirring pieces, and a plurality of auxiliary stirring pieces are arranged on the lower surface of the scraper ring, and the auxiliary stirring pieces are flush with the lower surface of the main stirring piece.

4. The liquid medicine mixing device for a perfusion machine according to claim 3, characterized in that: The stirring mechanism also includes gears and gear rings. The main stirring member includes a main stirring shaft fixed to the lower end of the liquid adding tube and a plurality of main stirring blades fixed on the main stirring shaft. Each main stirring blade has an inclination angle with the inner bottom surface of the tank body. The outer ends of the plurality of main stirring blades are respectively fixed to the inner circumference of the gear ring. The gear ring is rotatably installed on the scraper ring. The auxiliary stirring member includes an auxiliary stirring shaft and a plurality of auxiliary stirring blades fixed on the auxiliary stirring shaft. Each auxiliary stirring blade is perpendicular to the bottom surface of the tank body. The upper end of the auxiliary stirring shaft extends into the scraper ring and is equipped with a gear meshing with the gear ring.

5. The liquid medicine mixing device for a perfusion machine according to claim 2, characterized in that: The liquid adding pipe is provided with a liquid spraying port above the main stirring member, and a plurality of liquid spraying ports are evenly arranged along the circumference of the liquid adding pipe. The liquid adding pipe can be moved upward until the liquid spraying port is located between the sieve plate and the cover plate.

6. The liquid medicine mixing device for a perfusion machine according to claim 1, characterized in that: The liquid medicine mixing device of the filling machine also includes a linear driving component installed on the frame, and the output end of the linear driving component is connected to the liquid adding pipe to drive the liquid adding pipe to move up and down.

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