High-precision high-altitude environment simulation animal experiment cabin system and method

Abstract

The present application relates to the technical field of experimental animal research equipment, in particular to a high-precision high-altitude environment simulation animal experiment cabin system and method. The system comprises an environment control chamber and an intelligent adjustment system, an animal physiological parameter real-time monitoring system, an automatic feeding system, an automatic sample collection system, a data processing center and a monitoring system. The present application can simultaneously simulate multiple environmental factors such as air pressure, oxygen content, temperature, humidity and UV radiation, providing experimental conditions closer to the real high-altitude environment for research; adopts modular design, allowing flexible adjustment of system size and function according to research needs, adapting to different types of high-altitude related research; can significantly improve the quality and efficiency of high-altitude environment related research.

Description

Technical Field

[0001] This invention relates to the field of laboratory animal research equipment technology, specifically to a high-precision high-altitude environment simulation animal experimental chamber system and method. Background Technology

[0002] With the development of high-altitude areas and the increase in related medical research, the study of physiological responses in high-altitude environments has become increasingly important. However, conducting animal experiments in actual high-altitude environments faces many challenges, such as difficulty in precisely controlling environmental conditions, high experimental costs, and significant safety risks. Therefore, developing a system that can accurately simulate high-altitude conditions in a laboratory environment is of great significance.

[0003] Currently, there are some devices on the market that simulate high-altitude environments, but they generally have the following problems:

[0004] (1) Incomplete simulation of environmental parameters: Most devices can only simulate changes in air pressure and oxygen content, while ignoring other important environmental factors such as temperature, humidity, and ultraviolet radiation;

[0005] (2) Insufficient accuracy and stability: Existing equipment is difficult to maintain the stability of environmental parameters during long-term operation, which affects the reliability of experimental results;

[0006] (3) Low degree of automation: Many operations still require manual intervention, which increases experimental error and affects experimental efficiency;

[0007] (4) Lack of real-time monitoring and intelligent adjustment: The inability to adjust environmental parameters according to the real-time physiological state of animals limits the accuracy and flexibility of the experiment;

[0008] (5) Poor scalability: It is difficult to flexibly adjust the system size and functions according to different experimental needs.

[0009] Therefore, there is an urgent need to develop an animal experimental chamber system that can comprehensively, accurately, and stably simulate high-altitude environments, and has automated operation, real-time monitoring, intelligent adjustment, and good scalability. Summary of the Invention

[0010] To overcome the defects and deficiencies in the existing technology, the present invention provides a high-precision high-altitude environment simulation animal experimental chamber system and method.

[0011] This invention provides a high-precision high-altitude environment simulation animal experimental chamber system, comprising: an environmental control chamber and intelligent regulation system, a real-time animal physiological parameter monitoring system, an automated feeding system, an automated sample collection system, and a data processing center and monitoring system; wherein, the environmental control chamber and intelligent regulation system is used to simulate and control the air pressure, oxygen content, temperature, humidity, and gas composition radiation of the high-altitude environment; the real-time animal physiological parameter monitoring system is used for non-invasive monitoring of the physiological indicators and behavioral status of experimental animals; and the automated feeding system is used for automatic feeding and watering;

[0012] Automated sample collection systems are used for sample collection and waste disposal;

[0013] The data processing center and monitoring system are used to process and analyze data from the animal experimental area and environment in real time, provide corresponding feedback, and coordinate the work of various subsystems.

[0014] Preferably, the environmental control chamber and intelligent adjustment system includes a pressure control unit, which uses a high-precision vacuum pump and pressure sensor to adjust the air pressure inside the chamber and simulate air pressure changes at altitudes of 0-9000 meters.

[0015] The gas mixing unit consists of an oxygen source, a nitrogen source, and a mixer. By controlling the proportion of each gas component, the oxygen content can be adjusted to simulate the oxygen partial pressure at different altitudes.

[0016] The temperature and humidity control unit includes a refrigeration system, a heating system, and a humidity regulation device to simulate temperature and humidity changes in a high-altitude environment;

[0017] The ultraviolet simulation unit is equipped with adjustable-intensity UV lamps to simulate ultraviolet radiation in high-altitude environments.

[0018] The environmental parameter sensor group includes a barometer, an oxygen sensor, a temperature sensor, and a humidity sensor to monitor the cabin's environmental parameters in real time.

[0019] Preferably, the non-invasive physiological sensors include an electrocardiogram sensor, a respiration sensor, and a body temperature sensor; a weight detection device, located on the feeding platform, is used to measure the weight of the experimental animals while they are eating; and an image acquisition device is used to record animal behavior.

[0020] Preferably, the sample collection device includes a blood collection unit and an excrement collection unit.

[0021] Preferably, the data processing center and monitoring system mainly include:

[0022] Data acquisition module: Aggregates data streams from various subsystems;

[0023] Data storage unit: Adopts a distributed storage architecture to ensure the secure storage of large amounts of experimental data;

[0024] Real-time analytics engine: Utilizes stream processing technology to perform rapid analysis of real-time data;

[0025] Machine Learning Module: Applying deep learning algorithms to predict animal adaptation processes and optimize experimental parameters;

[0026] Visual interface: intuitively displays the experimental process and results, and supports interactive data exploration.

[0027] Preferably, it also includes an emergency system, which includes an emergency oxygen supply system, a rapid decompression device, a fault diagnosis system, and a multi-level alarm mechanism.

[0028] This invention also provides a high-precision method for simulating animal experiments in high-altitude environments, comprising the following steps:

[0029] (1) According to the experimental plan, the target environmental parameters are set through the data processing center and monitoring system;

[0030] (2) The environmental control chamber and intelligent regulation system adjust the cabin environment according to the set parameters;

[0031] (3) The real-time animal physiological parameter monitoring system continuously monitors the status of the experimental animals;

[0032] (4) The automated feeding and sample collection platform performs feeding and sample collection according to a preset program;

[0033] (5) The data processing center and monitoring system process the monitoring data in real time and dynamically adjust environmental parameters and experimental operations in real time.

[0034] Preferably, step (5) includes predicting the animal adaptation process, optimizing experimental parameters, and automatically adjusting the rate of change of environmental parameters according to the real-time physiological state of the experimental animal.

[0035] Compared with the prior art, the present invention has the following beneficial effects:

[0036] (1) Comprehensiveness and accuracy of environmental simulation: It can simultaneously simulate multiple environmental factors such as air pressure, oxygen content, temperature, humidity and UV radiation, providing experimental conditions that are closer to the real high-altitude environment for research.

[0037] (2) Long-term stability: Through a precise control system and feedback mechanism, the stability of environmental parameters during long-term experiments is ensured, thereby improving the reliability and repeatability of experimental results;

[0038] (3) High degree of automation: greatly reduces manual intervention, reduces experimental error, and improves experimental efficiency and data quality;

[0039] (4) Real-time monitoring and intelligent adjustment: It can dynamically adjust environmental parameters according to the real-time physiological state of animals, realize personalized experimental plans, and improve the accuracy and flexibility of research.

[0040] (5) Good scalability: The modular design allows for flexible adjustment of the system size and functions according to research needs, adapting to different types of high-altitude related research;

[0041] (6) Safe and reliable: Multiple safety protection mechanisms ensure experimental safety under simulated extreme environmental conditions, protecting experimental animals and researchers;

[0042] (7) Strong data analysis capabilities: The integrated data processing and analysis system can provide in-depth experimental data insights, assisting researchers in optimizing experimental plans and interpreting results;

[0043] (8) The high-precision high-altitude environment simulation animal experimental chamber system provided by the present invention can significantly improve the quality and efficiency of high-altitude environment-related research and provide important technical support for scientific breakthroughs in related fields. Attached Figure Description

[0044] Figure 1 This is a schematic diagram of the overall structure of the high-precision high-altitude environment simulation animal experimental chamber system of the present invention, as well as schematic diagrams of each system. Detailed Implementation

[0045] The present invention will now be described more completely and clearly with reference to the accompanying drawings and specific embodiments. The described embodiments are merely some, not all, of the embodiments of the present invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

[0046] Example 1 Figure 1 As shown, the high-precision high-altitude environment simulation animal experimental chamber system provided by the present invention mainly includes the following parts: an environmental control air chamber and intelligent adjustment system, a real-time animal physiological parameter monitoring system, an automated feeding system, an automated sample collection system, a data processing center and monitoring system, and an emergency system.

[0047] Each system is connected to the data processing center via a data bus, enabling information exchange and collaborative work. The entire system adopts a modular design, allowing for flexible combination and expansion according to experimental needs. The composition and functions of each subsystem are described below:

[0048] 1. Environmental control chamber and intelligent regulation system

[0049] The environmental control chamber and intelligent regulation system mainly include the following components:

[0050] Pressure control unit: Employing a high-precision vacuum pump and pressure sensor, it can precisely adjust the cabin air pressure to simulate air pressure changes at altitudes of 0-9000 meters.

[0051] Gas mixing unit: Composed of oxygen source, nitrogen source and mixer, it can adjust oxygen content by precisely controlling the gas ratio to simulate oxygen partial pressure at different altitudes.

[0052] Temperature and humidity control unit: includes a refrigeration system, a heating system, and a humidity control device, which can simulate temperature and humidity changes in high-altitude environments.

[0053] Ultraviolet simulation unit: Equipped with adjustable intensity UV lamps to simulate ultraviolet radiation in high-altitude environments.

[0054] Environmental parameter sensor group: including air pressure sensor, oxygen content sensor, temperature sensor and humidity sensor, to monitor cabin environmental parameters in real time.

[0055] The data processing center sends instructions to each unit according to the pre-set experimental plan. Each unit, based on the feedback sensor data, uses a PID control algorithm to precisely adjust and stably maintain environmental parameters.

[0056] 2. Real-time monitoring system for animal physiological parameters

[0057] The real-time monitoring system for animal physiological parameters mainly includes:

[0058] Non-invasive physiological sensors: including electrocardiogram sensors, respiration sensors and body temperature sensors, designed with wearable flexible materials to minimize interference with animals.

[0059] The weight detection device, located on the feeding platform, is used to measure the weight of laboratory animals while they are eating.

[0060] Image acquisition device: High-resolution camera used to record animal behavior.

[0061] The system continuously collects physiological signals and behavioral data from animals, and transmits the results to the data processing center to assess the animals' adaptation status and guide the adjustment of environmental parameters.

[0062] 3. Automated feeding and sample collection system

[0063] The automated feeding and sample collection system mainly includes:

[0064] Automatic feeding device: Timed and quantitative feeding is achieved through a programmable robotic arm and a quantitative feeder.

[0065] Automatic water dispenser: It adopts the principle of pressure balance to ensure a stable water supply under different air pressures.

[0066] Sample collection device: including blood collection unit and excrement collection unit, which can automatically collect biological samples without compromising the environmental integrity.

[0067] Waste treatment unit: Automatically collects and treats animal waste to maintain a hygienic environment inside the cabin.

[0068] Each device operates automatically according to a preset program, and is adjusted in real time according to the instructions of the control unit to adapt to the needs of different experimental stages.

[0069] 4. Data Processing Center and Monitoring System

[0070] The data processing center and monitoring system mainly include:

[0071] Data acquisition module: Aggregates data streams from various subsystems.

[0072] Data storage unit: Adopts a distributed storage architecture to ensure the secure storage of large amounts of experimental data.

[0073] Real-time analytics engine: Utilizes stream processing technology to perform rapid analysis of real-time data.

[0074] Machine Learning Module: Applying deep learning algorithms to predict animal adaptation processes and optimize experimental parameters.

[0075] Visual interface: intuitively displays the experimental process and results, and supports interactive data exploration.

[0076] Responsible for coordinating the work of various subsystems: communicating directly with each execution unit to achieve basic parameter adjustments.

[0077] Dynamically adjust control strategy: Based on preset experimental plans and real-time data, achieve intelligent decision-making and adaptive control.

[0078] The system continuously processes and analyzes data streams from other subsystems, generating real-time reports and early warning information. Simultaneously, it mines historical data through machine learning models to provide decision support for optimizing experimental protocols. The various compartment units can be stacked vertically or connected horizontally, flexibly adjusting the scale of the experiment.

[0079] 5. Emergency System

[0080] The system integrates multiple security protection measures, including:

[0081] Emergency oxygen supply system: automatically activated when oxygen levels are abnormal.

[0082] Rapid decompression device: can quickly restore the chamber pressure to normal pressure when needed.

[0083] Fault diagnosis system: Continuously monitors the working status of each unit and promptly identifies potential problems.

[0084] Multi-level alarm mechanism: Different levels of alarms are triggered based on the severity of the anomaly.

[0085] Redundancy design: Key components employ dual or triple redundancy to improve system reliability.

[0086] Through the above technical solutions, the high-precision high-altitude environment simulation animal experimental chamber system of the present invention can comprehensively, accurately and stably simulate the high-altitude environment, realize highly automated experimental operation and intelligent environmental control, and provide an advanced technical platform for high-altitude related research.

[0087] Example 2 is based on the high-precision high-altitude environment simulation animal experimental chamber system provided in Example 1. The high-precision high-altitude environment simulation animal experimental method in this example includes the following steps:

[0088] (1) According to the experimental plan, the target environmental parameters are set through the data processing center and monitoring system;

[0089] (2) The environmental control chamber and intelligent regulation system adjust the cabin environment according to the set parameters;

[0090] (3) The real-time animal physiological parameter monitoring system continuously monitors the status of the experimental animals;

[0091] (4) The automated feeding and sample collection platform performs feeding and sample collection according to a preset program;

[0092] (5) The data processing center and monitoring system process the monitoring data in real time and dynamically adjust the environmental parameters and experimental operations in real time, such as predicting the animal adaptation process and optimizing the experimental parameters; and automatically adjusting the rate of change of environmental parameters according to the real-time physiological state of the experimental animals.

Claims

1. A high-precision, high-altitude environment simulation animal experimental chamber system, characterized in that, include: The system includes an environmental control chamber and intelligent regulation system, a real-time animal physiological parameter monitoring system, an automated feeding system, an automated sample collection system, and a data processing center and monitoring system. The environmental control chamber and intelligent regulation system simulates and controls air pressure, oxygen content, temperature, humidity, and gas composition radiation in high-altitude environments. The real-time animal physiological parameter monitoring system non-invasively monitors the physiological indicators and behavioral status of laboratory animals. The automated feeding system automatically feeds and hydrates the animals. Automated sample collection systems are used for sample collection and waste disposal; The data processing center and monitoring system are used to process and analyze data from the animal experimental area and environment in real time, provide corresponding feedback, and coordinate the work of various subsystems. The environmental control chamber and intelligent regulation system include a pressure control unit, which uses a high-precision vacuum pump and pressure sensor to regulate the air pressure inside the chamber and simulate air pressure changes at altitudes of 0-9000 meters. The gas mixing unit consists of an oxygen source, a nitrogen source, and a mixer. By controlling the proportion of each gas component, the oxygen content can be adjusted to simulate the oxygen partial pressure at different altitudes. The temperature and humidity control unit includes a refrigeration system, a heating system, and a humidity regulation device to simulate temperature and humidity changes in a high-altitude environment; The ultraviolet simulation unit is equipped with an adjustable-intensity UV lamp to simulate ultraviolet radiation in high-altitude environments. The environmental parameter sensor group includes a barometer, an oxygen content sensor, a temperature sensor, and a humidity sensor to monitor the cabin environmental parameters in real time. Non-invasive physiological sensors include electrocardiogram sensors, respiration sensors, and body temperature sensors; a weight detection device, located on the feeding platform, is used to measure the weight of laboratory animals while they are eating; and an image acquisition device is used to record animal behavior.

2. The high-precision high-altitude environment simulation animal experimental chamber system according to claim 1, characterized in that: The sample collection device includes a blood collection unit and an excrement collection unit.

3. The high-precision high-altitude environment simulation animal experimental chamber system according to claim 1, characterized in that: The data processing center and monitoring system mainly include: The data acquisition module aggregates data streams from various subsystems; The data storage unit adopts a distributed storage architecture to ensure the secure storage of large amounts of experimental data; The real-time analytics engine utilizes stream processing technology to rapidly analyze real-time data. The machine learning module applies deep learning algorithms to predict animal adaptation processes and optimize experimental parameters. The visual interface intuitively displays the experimental process and results, and supports interactive data exploration.

4. The high-precision high-altitude environment simulation animal experimental chamber system according to claim 1, characterized in that: It also includes an emergency system, which includes an emergency oxygen supply system, a rapid decompression device, a fault diagnosis system, and a multi-level alarm mechanism.

5. A high-precision method for simulating animal experiments in high-altitude environments, utilizing the system described in any one of claims 1-4, characterized in that, Includes the following steps: (1) According to the experimental plan, the target environmental parameters are set through the data processing center and monitoring system; (2) The environmental control chamber and intelligent regulation system adjust the cabin environment according to the set parameters; (3) The real-time animal physiological parameter monitoring system continuously monitors the status of the experimental animals; (4) The automated feeding and sample collection platform performs feeding and sample collection according to a preset program; (5) The data processing center and monitoring system process the monitoring data in real time and dynamically adjust environmental parameters and experimental operations in real time.

6. The high-precision high-altitude environment simulation animal experiment method according to claim 5, characterized in that, Step (5) includes predicting the animal adaptation process and optimizing experimental parameters.

7. The high-precision high-altitude environment simulation animal experiment method according to claim 5, characterized in that, Step (5) includes automatically adjusting the rate of change of environmental parameters based on the real-time physiological state of the experimental animals.

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