Traditional Chinese medicine oral care solution as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of oral care, and particularly relates to a traditional Chinese medicine oral care solution as well as a preparation method and application thereof. Specifically, compared with traditional mouthwash, oral care solution and the like, the traditional Chinese medicine oral care solution provided by the invention contains various traditional Chinese medicine extracts which are matched with one another and have a synergistic effect, and has beneficial antibacterial, antiviral and salivation promoting effects. Meanwhile, the boric acid solution contained in the product plays a role in adjusting the pH value of the oral cavity, and the boric acid solution and the traditional Chinese medicine components are in synergistic interaction, so that the traditional Chinese medicine extracting solution can be assisted to improve the oral micro-ecology, the protection time of the traditional Chinese medicine extracting solution to the oral cavity is prolonged, and the purpose of nursing oral health is better achieved, and therefore, the product has good practical popularization and application value.

Description

Technical Field

[0001] The invention belongs to the technical field of oral care, and in particular relates to a traditional Chinese medicine oral care solution and a preparation method and application thereof. Background Art

[0002] The information disclosed in this background technology section is only intended to enhance the understanding of the overall background of the invention, and should not necessarily be regarded as an admission or any form of suggestion that the information constitutes the prior art already known to a person skilled in the art.

[0003] With the development of society and the improvement of people's living standards, oral health has received more and more attention. Due to factors such as aging, lack of medical treatment, and multiple medications, the elderly are more likely to have oral problems such as periodontal disease and oral mucosal abnormalities than young people.

[0004] In addition, it is worth noting that with the increase of age, the secretion of saliva in the human mouth gradually decreases, and the amount of saliva in the elderly is significantly lower than that in young people. Saliva contains three buffer systems: bicarbonate, phosphate, and protein buffer systems, and is an important buffer system for the oral cavity. When the amount of saliva is significantly reduced, the acid-base balance in the mouth is destroyed, and harmful bacteria are more likely to breed and multiply, which will have an adverse effect on periodontal health, mucosal health, dental health, and even respiratory health. Therefore, the elderly face more severe oral problems than young people. For intubated elderly people who cannot eat orally, because there is no stimulation of chewing, saliva secretion decreases sharply, and oral problems are more prominent.

[0005] At present, the main ways to clean the oral cavity are brushing teeth and rinsing with mouthwash (oral care liquid), but conventional brushing can only remove 40%-50% of the plaque on the tooth surface, and is basically powerless to remove bacteria on the surface of oral soft tissues. Mouthwash can penetrate into various parts of the oral cavity, including the gum margins and gaps between teeth that are difficult for toothbrushes to reach, improve gum health, and is a good auxiliary measure to control plaque. Mouthwash is easy to use and easy to carry, and is the best choice for the elderly to ensure oral hygiene.

[0006] Most of the mouthwashes on the market and those used in hospitals are configured with chemicals such as flavors, surfactants, fluoride, strontium chloride, alcohol, metronidazole, hydrogen peroxide, etc., which have good antibacterial effects, but are prone to drug resistance, and long-term use is prone to adverse drug reactions. In addition, this chemical mouthwash will irritate the oral mucosa. Long-term use will also damage the oral mucosa, and in severe cases, it may even cause oral mucosal exfoliation. The use of metronidazole mouthwash has adverse reactions such as taste changes and oral mucosal tingling, nausea, and vomiting. Long-term use of hydrogen peroxide can cause side effects such as tooth surface decalcification and black hairy tongue. In general, long-term use of chemical mouthwashes will pose a safety hazard to physical health. In addition, the mouthwashes currently on the market have not paid attention to the serious problem of oral acid-base balance destruction in the elderly, and there are no products that target the need to adjust the pH value of the elderly's mouth. Summary of the invention

[0007] In view of the deficiencies of the prior art, the present invention provides a Chinese medicine oral care solution for the elderly, and a preparation method and application thereof. According to experimental verification, the product has good antibacterial and antiviral capabilities and the ability to regulate the pH value of the oral cavity, can regulate the balance of oral microecology, reduce inflammation and relieve pain, freshen breath, improve the overall health of the oral cavity of the elderly, and also provide a good experience when used. Based on the above research results, the present invention is completed.

[0008] In order to achieve the above technical objectives, the technical solution adopted by the present invention is as follows: The first aspect of the present invention provides a Chinese medicine oral care solution, which comprises the following components in parts by weight: 2-5 parts of a Chinese medicine extract and 2-5 parts of a 3% boric acid solution; wherein the raw materials of the Chinese medicine extract include 5-20 parts of honeysuckle, 8-25 parts of mint, 8-25 parts of reed roots, 1-8 parts of Corydalis yanhusuo, 2-10 parts of Sophora flavescens, and 1-6 parts of Platycodon grandiflorum.

[0009] The second aspect of the present invention provides a method for preparing the above-mentioned Chinese medicine oral care solution, which comprises mixing the Chinese medicine extract with a 3% boric acid solution.

[0010] Wherein, the preparation method of the traditional Chinese medicine extract comprises: Weigh and mix Phragmites australis, Corydalis yanhusuo, Sophora flavescens and Platycodon grandiflorum according to the above weight proportion, add water and boil until boiling, then add honeysuckle and mint, continue heating, and filter the filtrate to obtain the traditional Chinese medicine extract.

[0011] The third aspect of the present invention provides the use of the above-mentioned Chinese medicine oral care solution in any one or more of the following: (a) Antimicrobial or preparation of antimicrobial products; (b) Antiviral or antiviral products; (c) regulating oral pH or preparing a product for regulating oral pH; (d) Anti-inflammatory and analgesic products or products prepared for anti-inflammatory and analgesic purposes; (e) breath freshening or breath freshening products; (f) Improving the overall health of the human oral cavity or preparing products that improve the overall health of the human oral cavity.

[0012] One or more beneficial technical effects of the above technical solution: Compared with traditional mouthwashes, oral care solutions, etc., the Chinese medicine oral care solution provided by the above technical solution has beneficial antibacterial, antiviral and salivation effects due to the combination of various Chinese medicine extracts. At the same time, the boric acid solution contained in this product plays a role in regulating the pH value of the oral cavity, and synergizes with the Chinese medicine ingredients to assist the Chinese medicine extract in improving the oral microecology, prolonging the protection time of the Chinese medicine extract on the oral cavity, and better achieving the purpose of oral health care, so it has good practical promotion and application value. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] The accompanying drawings in the specification, which constitute a part of the present invention, are used to provide a further understanding of the present invention. The exemplary embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute improper limitations on the present invention.

[0014] Figure 1 IC of the Chinese medicine extract and boric acid solution of the present invention 50 Experimental results; A and B are the inhibition rates against Escherichia coli; C and D are the inhibition rates against Staphylococcus aureus; E and F are the inhibition rates against Candida albicans.

[0015] Figure 2 The figures are the antibacterial test results of the Chinese medicine extract, boric acid solution and mixed solution of the present invention; wherein A is the inhibition rate against Escherichia coli; B is the inhibition rate against Staphylococcus aureus; and C is the inhibition rate against Candida albicans. DETAILED DESCRIPTION

[0016] It should be noted that the following detailed descriptions are all illustrative and intended to provide further explanation of the present invention. Unless otherwise specified, all technical and scientific terms used herein have the same meanings as those commonly understood by those skilled in the art to which the present invention belongs.

[0017] It should be noted that the terms used herein are only for describing specific embodiments and are not intended to limit exemplary embodiments according to the present invention. As used herein, unless the context clearly indicates otherwise, the singular form is also intended to include the plural form. In addition, it should be understood that when the terms "comprising" and / or "including" are used in this specification, they indicate the presence of features, steps, operations, devices, components and / or combinations thereof. It should be understood that the scope of protection of the present invention is not limited to the specific embodiments described below; it should also be understood that the terms used in the embodiments of the present invention are intended to describe specific embodiments, rather than to limit the scope of protection of the present invention.

[0018] In a typical specific embodiment of the present invention, a Chinese medicine oral care solution is provided, which comprises the following components in parts by mass: 2-5 parts of a Chinese medicine extract and 2-5 parts of a 3% boric acid solution; wherein the raw materials of the Chinese medicine extract include 5-20 parts of honeysuckle, 8-25 parts of mint, 8-25 parts of reed roots, 1-8 parts of Corydalis yanhusuo, 2-10 parts of Sophora flavescens, and 1-6 parts of Platycodon grandiflorum.

[0019] Furthermore, the Chinese medicine oral care solution comprises the following components in parts by weight: 2-5 parts of Chinese medicine extract, 2-5 parts of 3% boric acid solution, and 0-3 parts of water.

[0020] In my country, natural medicine (traditional Chinese medicine) has a long history of application, few toxic and side effects, and has bactericidal and anti-inflammatory effects, so it is widely used in basic research and clinical practice. Traditional Chinese medicine preparations are widely used in oral diseases. A large number of studies have shown that traditional Chinese medicine has good therapeutic effects in the treatment of periodontal disease, oral ulcers and other diseases. With people's attention to the safety of mouthwash, the advantages of traditional Chinese medicine mouthwashes have gradually emerged. Traditional Chinese medicine believes that the gums are the passage of the Yangming meridian, and the teeth are the rest of the bones. Oral diseases are mainly closely related to the stomach, large intestine and kidney of the Yangming meridian. Its etiology and pathogenesis are mostly caused by stomach fire, damp heat in the large intestine, and inflammation of virtual fire. Therefore, the present invention summarizes the traditional Chinese medicine used for daily oral health care, which should be mainly based on five categories: clearing heat, relieving pain, promoting body fluid, inhibiting bacteria and refreshing breath. In response to these five needs, the present invention is compatible with five traditional Chinese medicines-honeysuckle, mint, reed root, Corydalis, and Sophora flavescens, and the addition of Platycodon grandiflorum is used to adjust the taste.

[0021] Among them, mint is a plant of the Lamiaceae family, mint ( Mentha haplocalyxBriq.) is the dried aerial part of the plant. The whole plant is green and fragrant, and is one of the commonly used Chinese medicines. It is a pungent and cool sweating and antipyretic drug, and enters the lung meridian and liver meridian. It can dispel wind-heat, clear the head, relieve sore throat and rash, soothe the liver and promote qi, and is often used to treat aphthous ulcers, sore throat, throat, and gum swelling and pain. Studies have shown that the main components of mint are volatile oils, organic acids, flavonoids, etc. Volatile oil, as one of the main active ingredients of mint, has biological activities such as anti-inflammatory, analgesic, antibacterial, and anti-tumor; the catechol acid contained in mint is an effective anti-inflammatory agent, which can inhibit 3α-hydroxysteroid dehydrogenase and play an anti-inflammatory role. Mint can also promote the secretion of respiratory mucus, remove mucus attached to the mucosa, and reduce foamy sputum to increase the effective ventilation of the respiratory tract. In addition, mint contains a monoterpene compound that can reach the lungs through the blood circulation, making people feel fresh breath when breathing, and has the effect of relieving the discomfort of gingival inflammation and swelling. At the same time, mint has strong biological activity and has been proven to have antibacterial effects and can effectively prevent and treat oral ulcers.

[0022] Honeysuckle comes from the plant Lonicera japonica of the Caprifoliaceae family ( Lonicera japonica The dried buds or flowers of honeysuckle (Lonicera japonica Thunb.) have the effects of clearing away heat and detoxifying, and dispersing wind-heat. They are often used to treat heatstroke, prickly heat, furuncle, and sore throat. Studies have shown that honeysuckle can enhance immunity and inhibit the growth of a variety of viruses and bacteria. The functional ingredients of honeysuckle include flavonoids, organic acids, volatile oils, polyphenols, and triterpenoid saponins, which can enhance the phagocytic function of leukocytes.

[0023] Corydalis yanhusuo (Yuanhusuo) is a plant of the poppy family Corydalis yanhusuo ( CoryMis yanhusuo The dried tuber of WTWang is pungent, bitter and warm in nature and enters the liver and spleen meridians. It mainly has the effects of promoting blood circulation, promoting qi and relieving pain. Tetrahydropalmatine is the crystal of Corydalis extract and is the main active ingredient of Corydalis. It has a good analgesic effect. Studies have shown that Corydalis can help inhibit toothaches caused by caries, pulpitis, periodontitis, gingivitis, etc.

[0024] Sophora flavescens is a plant of the Leguminosae family. Sophora flavescens ) has the effect of clearing away heat and drying dampness, and is one of the commonly used Chinese herbal medicines in clinical practice. The alkaloids and flavonoids in Sophora flavescens are the material basis for its antibacterial, analgesic, anti-tumor and other pharmacological effects. As a natural medicine, Sophora flavescens has fewer side effects than Western medicine preparations such as chlorhexidine and levamisole, is not easy to develop tolerance, has a good antibacterial effect, and can also prevent, treat or assist in the treatment of oral mucosal damage, periodontitis, oral cancer and other diseases; Sophora flavescens extract can inhibit the growth, adhesion, acid production and sugar production of caries-causing bacteria in the planktonic and biofilm states, and has a good antibacterial effect. Because the matrine biogel with matrine as the main ingredient can help reduce the area of ​​oral ulcers, reduce the degree of oral mucosal damage, and reduce patient pain.

[0025] Phragmites australis is a grass plant Phragmites communis The fresh or dried rhizome of Trin. is cold in nature and sweet in taste. It has the effects of clearing away heat and purging fire, promoting body fluid and stopping vomiting, relieving restlessness and promoting diuresis. It has a good effect in treating dry mouth and can treat bad breath caused by dry tongue or swollen gums.

[0026] In another specific embodiment of the present invention, a method for preparing the above-mentioned Chinese medicine oral care solution is provided, and the preparation method comprises mixing the Chinese medicine extract with a 3% boric acid solution.

[0027] Wherein, the preparation method of the traditional Chinese medicine extract comprises: Weigh and mix Phragmites australis, Corydalis yanhusuo, Sophora flavescens, and Platycodon grandiflorum according to the above weight ratio, add water and boil until boiling, then add honeysuckle and mint, continue heating, and filter the filtrate to obtain the traditional Chinese medicine extract. The viscosity of the traditional Chinese medicine extract is 1.1-1.4 mPa·s.

[0028] Furthermore, in the above-mentioned method for preparing the traditional Chinese medicine extract, the material-liquid ratio is 1:5-20 (g / mL).

[0029] Further, soak in water for 10-60 minutes before decocting.

[0030] Furthermore, after boiling, heat over low heat for 10-30 minutes, add honeysuckle and mint, and then heat over low heat for another 5-20 minutes.

[0031] In another specific embodiment of the present invention, the use of the above-mentioned Chinese medicine oral care solution in any one or more of the following is provided: (a) Antimicrobial or preparation of antimicrobial products; (b) Antiviral or antiviral products; (c) regulating oral pH or preparing a product for regulating oral pH; (d) Anti-inflammatory and analgesic products or products prepared for anti-inflammatory and analgesic purposes; (e) breath freshening or breath freshening products; (f) Improving the overall health of the human oral cavity or preparing products that improve the overall health of the human oral cavity.

[0032] In another specific embodiment of the present invention, other auxiliary ingredients may be added to the product to obtain different dosage forms, such as aqueous solutions, emulsions, powders, gels, etc., which are not specifically limited here.

[0033] In particular, the product can be a daily chemical product or a medicine, especially an oral care product, such as the most common mouthwash, and the use methods include at least the following two methods: it can be used as a mouthwash in daily life; for intubated patients, a cotton swab can be used to dip the product and wipe the gums, teeth and other parts to clean the oral cavity. It is also worth mentioning that the present invention has a positive effect on improving the oral environment of the elderly.

[0034] The present invention is further explained by the following examples, but they are not intended to limit the present invention. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention.

[0035] Examples 1-7 and Comparative Examples 1-7 The preparation method of the Chinese medicine oral care solution in each embodiment and comparative example is as follows: Phragmites australis, Corydalis yanhusuo, Sophora flavescens, and Platycodon grandiflorum were weighed and mixed according to the mass of each embodiment and comparative example, 500 mL of purified water was added, stirred evenly, and soaked for 30 minutes, heated to boiling, heated over low heat for 20 minutes, honeysuckle and mint were added, heated over low heat for 10 minutes, and filtered to obtain filtrate A.

[0036] Take 250 mL of filtrate A, mix it with the 3% boric acid solution in each example and comparative example, and then add pure water to make up to 500 mL, mix and stir evenly to obtain an oral care solution.

[0037] 7 examples and 7 comparative examples are provided, and the specific formula is as follows:

[0038] Effect verification The properties of oral care solutions with different formulas are compared as follows:

[0039] From the experimental results, it can be seen that the color and taste of Examples 1, 2, 3, 5, and 6 are in a relatively good state; Example 4 has a sour taste because the proportion of 3% boric acid solution is relatively high; Example 7 has a strong and bitter taste because of the large amount of Chinese medicinal materials used. Comparative Example 7 has a sour taste because the proportion of 3% boric acid solution is too high, which is unacceptable in actual use.

[0040] The product's ability to regulate oral pH was tested. Saliva was collected before, 1 hour after, and 3 hours after use to test the pH value. The results are as follows:

[0041] The results show that the embodiment with a high amount of boric acid solution added has a better regulating effect on the pH value of the oral cavity than the embodiment with a low amount. When the 3% boric acid solution is added in an amount of 200 mL, it has a good regulating effect on the pH value of the oral cavity, and the pH value of the oral cavity can still be maintained within a reasonable range (6.6~7.1) after 3 hours of use. However, if the amount of 3% boric acid solution added is too high, the overall taste of the product will be too sour (Comparative Example 7), which is not suitable for use in real life. This product adjusts the pH value of the oral cavity by adding boric acid solution, which can keep it within a reasonable range. From the perspective of controlling the environment in which the bacteria are located, it avoids the excessive reproduction of harmful bacteria and has a certain antibacterial effect.

[0042] The prepared oral care solution was used for antibacterial test to examine whether the sample has antibacterial effect. The antibacterial effect test was carried out in accordance with QBT 2738-2012 "Evaluation Method for Antibacterial and Antibacterial Effect of Daily Chemical Products". Under the condition of 20℃-21℃, the oral care solution was used for 2min, and the test bacteria were Escherichia coli, Staphylococcus aureus and Candida albicans; when the antibacterial rate was ≥50%, it was marked as having antibacterial effect, and repeated three times; when the antibacterial rate was ≥90%, it was marked as having strong antibacterial effect, and repeated three times. The test results are as follows:

[0043] It can be seen from the experimental results that Example 7 has a strong antibacterial effect on Escherichia coli, Staphylococcus aureus, and Candida albicans, which is related to the large amount of Chinese medicinal materials used and the good antibacterial effect in Example 7. Examples 1-6 have antibacterial effects on Escherichia coli, Staphylococcus aureus, and Candida albicans, among which Examples 3 and 4 have more prominent effects. The Chinese medicinal materials in these two examples have a suitable ratio and have a good antibacterial effect; at the same time, the addition amount of 3% boric acid solution is appropriate, which can well adjust the pH value of the oral cavity, inhibit the growth and reproduction of harmful bacteria, and cooperate with Chinese medicinal materials to exert a good antibacterial effect from the two perspectives of controlling environmental conditions and direct antibacterial.

[0044] In order to prove that the Chinese medicine solution and the boric acid solution have a synergistic effect in antibacterial function, the following experiment was conducted. First, different volumes of Chinese medicine solution (the medicinal material ratio in Example 3) and 3% boric acid solution were taken to make the volume to 500 mL, and an antibacterial test was performed to determine the IC 50 The experimental results are as follows Figure 1 As shown, for Escherichia coli, Chinese medicine liquid IC 50 The value is 253.82mL, and the IC value of boric acid solution is 50 The value is 4.95%; for Staphylococcus aureus, the IC 50 The value is 204.86 mL, and the IC value of boric acid solution is 50 The value is 6.11%; for Candida albicans, the Chinese medicine liquid IC 50The value is 232.13 mL, and the IC value of boric acid solution is 50 The value is 4.08%.

[0045] The combination of traditional Chinese medicine liquid and boric acid liquid was used as the experimental object to detect the inhibitory ability against three kinds of bacteria. The specific concentrations of each experimental object were set as follows:

[0046] Concentration gradient setting principle: The concentration of the present invention is based on IC 50 The value is based on 1 / 4IC 50 、1 / 2IC 50 、IC 50 As concentration gradient. The inhibition rate at each concentration is shown in Figure 2 .

[0047] according to Figure 2 The inhibition rate in the calculation was used to obtain the combined inhibition index of the Chinese medicine solution and the boric acid solution at different concentration ratios. According to the data results, the effects of the Chinese medicine solution and the boric acid solution at each concentration ratio were synergistic.

[0048]

[0049] Note: The combination index is CI. When the CI value is less than 0.9, it is a synergistic effect; when 0.9 < CI value < 1.1, it is an additive effect; when the CI value is greater than 1.1, it is an antagonistic effect.

[0050] Combined with the above experiments, four examples with better Chinese medicine ratios and boric acid solution ratios and four representative comparative examples were selected for population experiments. After using the oral care solution for ten consecutive days, a questionnaire survey was conducted on the users to investigate the effects of the use, and the results are as follows:

[0051] The experimental results show that the amount of Chinese medicinal materials added to the oral care solution that clear away heat and detoxify, reduce inflammation and relieve pain has a significant effect on problems such as swollen and painful gums; the amount of Chinese medicinal materials added to freshen breath has a slightly weaker effect on the degree of improvement in breath; the addition of Chinese medicinal materials that inhibit bacteria and disinfect and regulate the oral microecological environment significantly improves the severity of dental plaque; the addition of 3% boric acid solution has a good synergistic effect on the efficacy of Chinese medicinal materials. Generally speaking, in a relatively short period of time, the oral care solution of the present invention has a positive effect on improving the oral environment of the elderly.

[0052] The above embodiments are only for illustrating the technical concept and features of the present invention, and their purpose is to enable people familiar with the technology to understand the content of the present invention and implement it accordingly, and they cannot be used to limit the protection scope of the present invention. Any equivalent changes or modifications made according to the spirit of the present invention should be included in the protection scope of the present invention.

Claims

1. A Chinese medicine oral care solution, comprising the following components by weight: 2-5 parts of Chinese medicine extract, 2-5 parts of 3% boric acid solution; wherein, The raw materials of the traditional Chinese medicine extract include 5-20 parts of honeysuckle, 8-25 parts of mint, 8-25 parts of reed root, 1-8 parts of Corydalis yanhusuo, 2-10 parts of sophora flavescens and 1-6 parts of platycodon.

2. The Chinese medicine oral care solution as claimed in claim 1, characterized in that The Chinese medicine oral care solution comprises the following components in parts by weight: 2-5 parts of Chinese medicine extract, 2-5 parts of 3% boric acid solution, and 0-3 parts of water.

3. The method for preparing the Chinese medicine oral care solution according to any one of claims 1 to 2, characterized in that: The preparation method comprises mixing a traditional Chinese medicine extract with a 3% boric acid solution.

4. The preparation method according to claim 3, characterized in that: The preparation method of the Chinese medicine extract comprises: Weigh and mix Phragmites australis, Corydalis yanhusuo, Sophora flavescens and Platycodon grandiflorum according to the above weight proportion, add water and boil until boiling, then add honeysuckle and mint, continue heating, and filter the filtrate to obtain the traditional Chinese medicine extract.

5. The preparation method according to claim 3, characterized in that: In the above-mentioned method for preparing the traditional Chinese medicine extract, the solid-liquid ratio is 1:5-20 (g / mL).

6. The preparation method according to claim 3, characterized in that: Soak in water for 10-60 minutes before decocting.

7. The preparation method according to claim 3, characterized in that: After boiling, simmer for 10-30 minutes, add honeysuckle and mint, and simmer for another 5-20 minutes.

8. Use of the Chinese medicine oral care solution according to claim 1 or 2 in any one or more of the following: (a) Antimicrobial or preparation of antimicrobial products; (b) Antiviral or antiviral products; (c) regulating oral pH or preparing a product for regulating oral pH; (d) Anti-inflammatory and analgesic products or products prepared for anti-inflammatory and analgesic purposes; (e) breath freshening or breath freshening products; (f) Improving the overall health of the human oral cavity or preparing products that improve the overall health of the human oral cavity.

9. The use according to claim 8, characterized in that The product is an aqueous solution, emulsion, powder or gel.

10. The use according to claim 8, characterized in that The product is administered to the elderly.

Images