A kind of ablation treatment system and control method thereof

Abstract

The present invention discloses an ablation treatment system and a control method thereof, comprising: a pulse output module, a first switch module, a second switch module, a radio frequency output module and a controller; the controller is used to output a pulse control signal to the pulse output module, and output a first switch control signal to the first switch module, and output a second switch control signal to the second switch module; the pulse output module is used to output a pulse voltage signal according to the pulse control signal; the first switch module is used to transmit the pulse voltage signal to the electrode when it is turned on; the second switch module is used to transmit the pulse voltage signal provided by the pulse output module to the radio frequency output module when it is turned on; the radio frequency output module is used to output a radio frequency signal to the electrode according to the pulse voltage signal when receiving the pulse voltage signal, so as to realize the switching of the pulse voltage signal and the radio frequency signal, thereby improving the flexibility of the ablation treatment process and being conducive to improving the efficiency of the ablation treatment.

Description

Technical Field

[0001] The present invention relates to the field of medical technology, and in particular to an ablation treatment system and a control method thereof. Background Art

[0002] Cardiac electrophysiology refers to the bioelectric phenomenon of myocardial cells, which is the basis for the principle of electrocardiogram and the pathogenesis of arrhythmia. There is a potential difference between the inside and outside of the myocardial cell membrane, and the excitement of myocardial cells will cause changes in the potential difference between the inside and outside of the cell membrane. In the resting state, the myocardial cell membrane contains sodium ions, and the outside of the cell membrane contains potassium ions and chloride ions. When myocardial cells are excited, a potential difference will be generated, causing potassium to flow in and sodium to flow out, causing myocardial cells to depolarize and contract. Conversely, when myocardial cells are repolarized, sodium ions flow in and potassium ions flow out. Therefore, when the electrical activity of myocardial cells is abnormal, it will lead to arrhythmia.

[0003] Arrhythmia refers to the abnormal phenomenon of changes in heart rhythm and heart rate, which is mainly caused by changes in the generation or conduction of electrical activity in the myocardium. In a healthy heart, the sinoatrial node acts as a pacemaker, generating electrical impulses that are then conducted through the atria to the ventricles, hence the name "sinus rhythm." The sinoatrial node, atrioventricular node, atrioventricular bundle, and Purkinje fibers act as a network for the conduction of cardiac electrical current, stimulating the heart to beat and maintaining the normal operation of the human body's blood system. Atrial fibrillation occurs when the pacemaker cells in the sinoatrial node spontaneously generate electrical impulses that cause depolarization, or when the pulse conduction of action potentials outside the sinoatrial node is altered.

[0004] At present, ablation surgery is the main means of treating arrhythmias. The electrode catheter is inserted into the heart through the groin or neck area, and the electrode at the tip of the catheter detects the electrophysiological characteristics of the heart. The location of the abnormal electrical signal is determined as the site to be ablated. Once the precise location is determined, the doctor can transmit energy through the catheter to perform ablation in the local area to restore the heart rhythm to normal levels.

[0005] The current ablation techniques are divided into three types: radiofrequency ablation (RFA), cryoablation (Cryo) and pulsed field ablation (PFA). Radiofrequency ablation is an interventional technique that delivers an electrode catheter into a specific part of the heart cavity through a vein or artery to release radiofrequency current to cause local endocardial and subendocardial myocardial coagulative necrosis, thereby blocking the abnormal conduction bundle and origin of rapid arrhythmias. By introducing high-frequency radiofrequency energy into the heart tissue, heat energy is generated to burn abnormal potential conduction pathways or ectopic pacemakers inside the heart, thereby restoring or maintaining the normal heart rhythm.

[0006] Cryoablation is also a procedure that sends a balloon catheter to the heart. The cryoballoon system uses low temperature to ablate the myocardium, causing necrosis of tissue cells around the pulmonary veins and loss of electrical conduction, thereby achieving the purpose of pulmonary vein ablation. Cryoballoon ablation is a new technology designed specifically to isolate the pulmonary veins for the treatment of atrial fibrillation, and is also a fairly mature minimally invasive interventional treatment method. The principle is to use refrigerants to lower the temperature of heart tissue, block the activity of cell tissues that induce arrhythmias, and thus reduce the risk of atrial fibrillation.

[0007] The basic principle of pulsed field ablation is electroporation. Applying high-voltage electric pulses to the phospholipid bilayer of the cell membrane in a short period of time leads to the formation of transmembrane potential, which in turn generates unstable electric potentials. The cell membrane forms irreversible penetrating damage, resulting in nanoscale pores, which in turn leads to changes in cell membrane permeability, destroys the homeostasis of the intracellular environment, and ultimately causes cell apoptosis. Pulse ablation has the advantages of short operation time, quick results, and less damage, and is a new generation of treatment technology for arrhythmias.

[0008] At present, the ablation method used for ablation treatment equipment is single. In actual application, there are complex pathological conditions. If only a single pulse ablation is used for treatment, it is impossible to treat the diseased tissue at certain specific angles in the heart. It is necessary to replace the treatment equipment and the electrode catheter for secondary treatment, which greatly increases the patient's surgical risk and cost. If radiofrequency ablation is used directly for treatment, the overall operation time is long, and because the principle of radiofrequency ablation is thermal ablation, more ablation points are prone to thermal perforation and nerve damage. If only pulsed field ablation is used for treatment, general anesthesia and intubation are required to reduce the impact of muscle contraction on ablation positioning accuracy and catheter stability. In addition, the pulse parameters during pulsed field ablation are relatively complex. As the treatment process progresses, the biological tissue will change to varying degrees, making it difficult to determine the precise pulse parameters. Summary of the invention

[0009] The present invention provides an ablation treatment system and a control method thereof to solve the problem of a single ablation method during treatment, and can realize the switching between pulse energy and radio frequency energy.

[0010] According to one aspect of the present invention, there is provided an ablation treatment system, comprising: a pulse output module, a first switch module, a second switch module, a radio frequency output module and a controller;

[0011] The first switch module is electrically connected between the pulse output module and at least two electrodes; the second switch module is electrically connected between the pulse output module and the radio frequency output module, and the radio frequency output module is also electrically connected to at least two electrodes; the controller is electrically connected to the pulse output module, the first switch module and the second switch module respectively;

[0012] The controller is used to output a pulse control signal to the pulse output module, and output a first switch control signal to the first switch module, and output a second switch control signal to the second switch module;

[0013] The pulse output module is used to output a pulse voltage signal according to the pulse control signal;

[0014] The first switch module is used to be turned on or off according to the first switch control signal, and transmit the pulse voltage signal to the electrode when turned on;

[0015] The second switch module is used to be turned on or off according to the second switch control signal, and transmit the pulse voltage signal provided by the pulse output module to the RF output module when turned on;

[0016] The radio frequency output module is used to output a radio frequency signal to the electrode according to the pulse voltage signal when receiving the pulse voltage signal.

[0017] According to another aspect of the present invention, a control method for an ablation therapy system is provided, which is applied to the above-mentioned ablation therapy system, comprising:

[0018] During ablation therapy, obtaining the current dielectric characteristics of the target biological tissue;

[0019] determining whether to continue outputting ablation energy according to the dielectric characteristics;

[0020] If so, determining the type of ablation energy based on the dielectric characteristics;

[0021] Controlling the state of the first switch module and the state of the second switch module according to the type of the ablation energy;

[0022] When the ablation energy type is pulse energy, the first switch module is controlled to be turned on and the second switch module is turned off; and when the ablation energy type is radio frequency energy, the second switch module is controlled to be turned on and the first switch module is turned off.

[0023] The ablation therapy system provided by the present invention outputs a pulse voltage signal according to a pulse control signal through a pulse output module, and converts the pulse voltage signal into a radio frequency signal through a radio frequency output module. During the ablation therapy, the pulse voltage signal can be selected for pulse field ablation according to the treatment needs, or the radio frequency signal can be selected for radio frequency ablation. The states of the first switch module and the second switch module are controlled by a controller to realize the switching of the pulse voltage signal and the radio frequency signal, thereby improving the flexibility of the ablation therapy process and facilitating improving the efficiency of the ablation therapy.

[0024] It should be understood that the contents described in this section are not intended to identify the key or important features of the embodiments of the present invention, nor are they intended to limit the scope of the present invention. Other features of the present invention will become easily understood through the following description. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0026] Figure 1 is a structural schematic diagram of an ablation treatment system provided by an embodiment of the present invention;

[0027] Figure 2 is a schematic structural diagram of another ablation treatment system provided by an embodiment of the present invention;

[0028] Figure 3 is a structural schematic diagram of a pulse output module provided by an embodiment of the present invention;

[0029] Figure 4 is a pulse voltage waveform diagram provided by an embodiment of the present invention;

[0030] Figure 5 is another pulse voltage waveform diagram provided by an embodiment of the present invention;

[0031] Figure 6 is a flow chart of a first control method of an ablation therapy system provided by an embodiment of the present invention;

[0032] Figure 7 is a flow chart of a second control method of an ablation therapy system provided by an embodiment of the present invention;

[0033] Figure 8 is a flow chart of a third control method of an ablation treatment system provided by an embodiment of the present invention;

[0034] Fig. 9 is a flow chart of a fourth control method of an ablation therapy system provided by an embodiment of the present invention;

[0035] Fig.10 This is a flow chart of a fifth method for controlling an ablation therapy system provided by an embodiment of the present invention. DETAILED DESCRIPTION

[0036] In order to enable those skilled in the art to better understand the scheme of the present invention, the technical scheme in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work should fall within the scope of protection of the present invention.

[0037] It should be noted that the terms "first", "second", etc. in the specification and claims of the present invention and the specification are used to distinguish similar objects, and are not necessarily used to describe a specific order or sequence. It should be understood that the data used in this way can be interchanged where appropriate, so that the embodiments of the present invention described herein can be implemented in an order other than those illustrated or described herein. In addition, the terms "including" and "having" and any variations thereof are intended to cover non-exclusive inclusions, for example, a process, method, system, product or device that includes a series of steps or units is not necessarily limited to those steps or units that are clearly listed, but may include other steps or units that are not clearly listed or inherent to these processes, methods, products or devices.

[0038] An embodiment of the present invention provides an ablation treatment system. Figure 1 FIG. 1 is a schematic diagram of a structure of an ablation treatment system provided by an embodiment of the present invention. Figure 1 As shown, the ablation treatment system includes a pulse output module 10, a first switch module 20, a second switch module 30, a radio frequency output module 40 and a controller 50; the first switch module 20 is electrically connected between the pulse output module 10 and at least two electrodes P; the second switch module 30 is electrically connected between the pulse output module 10 and the radio frequency output module 40, and the radio frequency output module 40 is also electrically connected to at least two electrodes P; the controller 50 is electrically connected to the pulse output module 10, the first switch module 20 and the second switch module 30 respectively. The controller 50 is used to output a pulse control signal to the pulse output module 10, as well as to output a first switch control signal to the first switch module 20 and a second switch control signal to the second switch module 30; the pulse output module 10 is used to output a pulse voltage signal according to the pulse control signal; the first switch module 20 is used to be turned on or off according to the first switch control signal, and transmit the pulse voltage signal to the electrode P when turned on; the second switch module 30 is used to be turned on or off according to the second switch control signal, and transmit the pulse voltage signal provided by the pulse output module 10 to the RF output module 40 when turned on; the RF output module 40 is used to output a RF signal to the electrode P according to the pulse voltage signal when receiving the pulse voltage signal.

[0039] Specifically, the ablation treatment system can be configured to be electrically connected to a plurality of electrodes P. When performing ablation treatment, an ablation energy signal can be output to one pair of electrodes (ie, two electrodes P). Figure 1 It is only exemplarily shown that the ablation treatment system is electrically connected to two pairs of electrodes P (ie, four electrodes), namely, the first electrode P1 , the second electrode P2 , the third electrode P3 and the fourth electrode P4 , but it is not limited thereto.

[0040] When the ablation treatment method adopted is pulsed field ablation, the controller 50 can control the second switch module 30 to be completely disconnected, and control the first switch module 20 to be turned on, and then can control the pulse output module 10 so that the pulse output module 10 can output a voltage signal to two electrodes P therein through the first switch module 20, so that the voltage between the two electrodes P presents a pulse voltage waveform with a certain pulse width.

[0041] When the ablation treatment method adopted is radiofrequency ablation, the controller 50 can control the first switch module 20 to be completely disconnected, and control the second switch module 30 to be turned on, so that the pulse output module 10 can output a pulse voltage signal to the radio frequency output module 40 through the second switch module 30, so that the radio frequency output module 40 can convert the pulse voltage signal into a radio frequency signal and output it to the corresponding electrode P.

[0042] The ablation therapy system provided by the embodiment of the present invention outputs a pulse voltage signal according to a pulse control signal through a pulse output module, and converts the pulse voltage signal into a radio frequency signal through a radio frequency output module. During the ablation therapy, the pulse voltage signal can be selected for pulse field ablation according to the treatment requirements, or the radio frequency signal can be selected for radio frequency ablation. The states of the first switch module and the second switch module can be controlled by a controller to realize the switching of the pulse voltage signal and the radio frequency signal, thereby improving the flexibility of the ablation therapy process and facilitating improving the efficiency of the ablation therapy.

[0043] Figure 2 FIG. 1 is a schematic diagram of the structure of another ablation treatment system provided by an embodiment of the present invention. Figure 2 As shown, the pulse output module 10 includes a plurality of pulse output units 10′, the first switch module 20 includes a first switch K1 corresponding to each pulse output unit 10′, and the second switch module 30 includes a second switch K2 corresponding to each pulse output unit 10′; each pulse output unit 10′ is electrically connected to the controller 50, respectively, and the output end of each pulse output unit 10′ is electrically connected to the corresponding first switch K1 in the first switch module 20, and the output end of each pulse output unit 10′ is also electrically connected to the corresponding second switch K2 in the second switch module 30; each first switch K1 is also electrically connected to a different electrode P, respectively, and each second switch K2 is also electrically connected to the radio frequency output module 40.

[0044] Specifically, the first switch module 20 may include a first switch K1 corresponding to each pulse output unit 10'. When the ablation treatment method adopted is pulse field ablation, at least two first switches K1 in the first switch module 20 may be controlled to be turned on, so that the pulse voltage signal output by the pulse output module 10 can be transmitted to the corresponding two electrode P ends respectively through the turned-on first switch K1, and then the pulse voltage signal can be output to the target biological tissue through the electrode P, thereby realizing the pulse field ablation treatment of the target biological tissue.

[0045] The second switch module 30 may include at least two second switches K2. When the ablation treatment method adopted is radiofrequency ablation, the controller 50 may control at least one second switch K2 in the second switch module 30 to be turned on, so that the current path between the pulse output module 10 and the radiofrequency output module 40 is in a conducting state, and the pulse voltage signal output by the pulse output module 10 can be output to the radiofrequency output module 40 through the second switch module 30. When the radiofrequency output module 40 receives the pulse voltage signal, it can convert the pulse voltage signal into a radiofrequency signal, so that the radiofrequency signal can be output to the corresponding electrode P end, so that the radiofrequency signal can be output to the target biological tissue through the electrode P, and the radiofrequency ablation treatment of the target biological tissue can be achieved.

[0046] In a preferred embodiment, the first switch module 20 and the second switch module 30 are always asynchronously turned on, so that the ablation treatment system can select one of the output pulse voltage signal and the radio frequency signal at the same time.

[0047] Each first switch K1 in the first switch module 20 can be a relay switch or a controllable transistor, such as a triode, an insulated gate field effect transistor, an IGBT, etc. Similarly, each second switch K2 in the second switch module 30 can also be a relay switch or a controllable transistor, such as a triode, an insulated gate field effect transistor, an IGBT, etc. The control end of each first switch K1 and each second switch K2 is electrically connected to the controller 50 to be controlled to be turned on or off by the controller 50. The embodiment of the present invention does not specifically limit the switch type in the first switch module 20 and the second switch module 30. Figure 2 The first switch K1 and the second switch K2 are both relay switches, but the present invention is not limited thereto. The relay coils of the first switch K1 and the second switch K2 can be electrically connected to the controller 50, and the controller 50 controls the coils to be powered on or off, thereby controlling the first switch K1 and the second switch K2.

[0048] Each pulse output unit 10' is electrically connected to the controller 50, and the output end of each pulse output unit 10' is electrically connected to a corresponding first switch K1 in the first switch module 20, and the output end of each pulse output unit 10' is also electrically connected to a corresponding second switch K2 in the second switch module 30. In this way, one pulse output unit 10' can output a pulse voltage signal to one electrode P, or one pulse output unit 10' can independently provide a pulse voltage signal to the RF output module. Corresponding to the four electrodes P, Figure 2 The pulse output module 10 is exemplarily shown to include four pulse output units 10′, namely a first pulse output unit 11, a second pulse output unit 12, a third pulse output unit 13 and a fourth pulse output unit 14, wherein the first pulse output unit 11 is electrically connected to the first electrode P1 through the corresponding first switch K1, the second pulse output unit 12 is electrically connected to the second electrode P2 through the corresponding first switch K1, the third pulse output unit 13 is electrically connected to the third electrode P3 through the corresponding first switch K1, and the fourth pulse output unit 14 is electrically connected to the fourth electrode P4 through the corresponding first switch K1.

[0049] Optionally, the circuit structures of the pulse output units 10 ′ may be the same. Figure 3 is a schematic diagram of the structure of a pulse output module provided by an embodiment of the present invention, such as Figure 3 As shown, the pulse output unit 10′ may include a first transistor Q1, a second transistor Q2, a third transistor Q3 and a fourth transistor Q4; in the same pulse output unit 10′, the first electrode of the first transistor Q1 is electrically connected to the DC voltage terminal VDD, the second electrode of the first transistor Q1 is electrically connected to the first electrode of the second transistor Q2, the first electrode of the third transistor Q3 is electrically connected to the second electrode of the second transistor Q2 to the first node N1, the first end of the fourth transistor Q4 is electrically connected to the second electrode of the third transistor Q3, the second end of the fourth transistor Q4 is electrically connected to the ground terminal GND, the control electrode of the first transistor Q1, the control electrode of the second transistor Q2, the control electrode of the third transistor Q3 and the control electrode of the fourth transistor Q4 are all connected to the controller 50, and can be respectively connected to different pulse control signal output terminals of the controller 50. Among them, the first node N1 is electrically connected to the corresponding first switch K1 in the first switch module 20, and the first node N1 is also electrically connected to the corresponding second switch K2 in the second switch module 30.

[0050] The first node N1 is the output terminal of the pulse output unit 10′. Figure 2The first node N1 can be electrically connected to a first switch K1 in the first switch module 20, and electrically connected to a corresponding electrode P through the first switch K1, and the first node N1 can be electrically connected to a second switch K2 in the second switch module 30, and electrically connected to the RF output module 40 through the second switch K2. The DC voltage terminal VDD can provide a DC voltage Udc.

[0051] Among them, the first transistor Q1, the second transistor Q2, the third transistor Q3 and the fourth transistor Q4 can be PMOS, NMOS or other types of transistors such as IGBT, TFT, etc., and the types of each transistor can be the same or different. The embodiment of the present invention does not make specific limitations on this. For the sake of convenience of explanation, the embodiment of the present invention preferably sets the first transistor Q1, the second transistor Q2, the third transistor Q3 and the fourth transistor Q4 to be NMOS. At this time, the first electrode of each transistor can be a drain, the second electrode can be a source, and the control electrode can be a gate.

[0052] Exemplary, reference Figure 3 The pulse output module 10 may further include a first capacitor C1 and a second capacitor C2, which are connected in series between the DC voltage terminal VDD and the ground terminal GND as storage capacitors for storing voltage signals. The connection node between the first capacitor C1 and the second capacitor C2 is a second node N2.

[0053] Optionally, the pulse output unit 10' may further include a first diode D1 and a second diode D2. In the same pulse output unit 10', the cathode of the first diode D1 is electrically connected to the second electrode of the first transistor Q1 and the first electrode of the second transistor Q2, the cathode of the second diode D2 is electrically connected to the anode of the first diode D1 at the third node N3, and the anode of the second diode D2 is electrically connected to the second electrode of the third transistor Q3 and the first electrode of the fourth transistor Q4. The third node N3 of each pulse output unit 10' is electrically connected to the second node N2.

[0054] Optional, continue to refer to Figure 2 The RF output module 40 may include a plurality of power band-stop filters 40′, and the power band-stop filters 40′ may be arranged one-to-one with the pulse output units 10′, then each power band-stop filter 40′ may be electrically connected to the corresponding pulse output unit 10′ through the corresponding second switch K2, and each power band-stop filter 40′ is electrically connected to an electrode P respectively.

[0055] Exemplarily, corresponding to the four pulse output units 10', the RF output module 40 may include four power band-stop filters 40', which may be respectively a first power band-stop filter 41, a second power band-stop filter 42, a third power band-stop filter 43 and a fourth power band-stop filter 44. In order to facilitate the explanation of the working principle of the ablation treatment system, the first power band-stop filter 41 may be electrically connected to the first pulse output unit 11 through a corresponding second switch K2, and the first power band-stop filter 41 may be electrically connected to the first electrode P1; the second power band-stop filter 42 may be electrically connected to the second pulse output unit 12 through a corresponding second switch K2, and the second power band-stop filter 42 may be electrically connected to the second electrode P2; the third power band-stop filter 43 may be electrically connected to the third pulse output unit 13 through a corresponding second switch K2, and the third power band-stop filter 43 may be electrically connected to the third electrode P3; the fourth power band-stop filter 44 may be electrically connected to the fourth pulse output unit 14 through a corresponding second switch K2, and the fourth power band-stop filter 44 may be electrically connected to the fourth electrode P4. The power band-stop filter 40' may be a filter circuit composed of inductors and capacitors with different parameters, which can realize the conversion between pulse voltage signals and radio frequency signals. The present invention does not specifically limit the specific structure of the power band-stop filter 40'.

[0056] Based on the above-mentioned ablation treatment system, the embodiment of the present invention can realize the switching of pulse voltage signals and radio frequency signals, and can control the states of the first switch module 20 and the second switch module 30 according to needs during the treatment process, so that the pulse voltage signal can be output to the electrode P to realize the output of pulse energy and realize pulse field ablation of the target biological tissue, or the radio frequency signal can be output to the electrode P to realize the output of radio frequency energy and realize radio frequency ablation of the target biological tissue. The working principle of the ablation treatment system is explained exemplarily below.

[0057] Specifically, when it is determined that the ablation energy is pulse energy, the controller 50 can control each second switch K2 in the second switch module 30 to be in the disconnected state. At this time, each power band-stop filter 40′ in the radio frequency output module 40 cannot receive the pulse voltage signal, and thus cannot output the radio frequency signal to the corresponding electrode P. At the same time, the controller 50 can select two of the first switches K1 in the first switch module 20 to be turned on, and control the other two first switches K1 to be turned off. Assuming that the controller 50 controls the first switch K1 electrically connected to the first pulse output unit 11 to be turned on, and controls the first switch K1 electrically connected to the third pulse output unit 13 to be turned on, at this time, the controller 50 can control the state of each transistor in the first pulse output unit 11 and the third pulse output unit 13, so that the voltage between the first electrode P1 and the third electrode P3 is a pulse voltage with a certain pulse width. Alternatively, the controller 50 may select all the first switches K1 in the first switch module 20 to be turned on. At this time, the transistors in the second pulse output unit 12 and the fourth pulse output unit 14 may be controlled to remain in the off state, and by controlling the state of each transistor in the first pulse output unit 11 and the third pulse output unit 13, the corresponding voltage signal is output to the corresponding first electrode P1 and the third electrode P3, so that the voltage between the first electrode P1 and the third electrode P3 is a pulse voltage with a certain pulse width.

[0058] For example, Figure 4 This is a pulse voltage waveform diagram provided by an embodiment of the present invention, combined with reference Figure 2 , Figure 3 and Figure 4 , control the transistors in the second pulse output unit 12 and the fourth pulse output unit 14 to remain in the off state. In this process, when the first transistor Q1 and the second transistor Q2 in the first pulse output unit 11 are turned on and the third transistor Q3 and the fourth transistor Q4 are turned off during the 0-t1 period, the first transistor Q1 and the second transistor Q2 in the third pulse output unit 13 can be controlled to be turned off and the third transistor Q3 and the fourth transistor Q4 are turned on. At this time, the voltage V P1 The voltage Udc provided by the DC voltage terminal VDD, the voltage V P3 is 0V, then the voltage V between the first electrode P1 and the third electrode P3 P1-P3 When the first transistor Q1 and the second transistor Q2 in the first pulse output unit 11 are turned off and the third transistor Q3 and the fourth transistor Q4 are turned on during the period t1 to t2, the first transistor Q1 and the second transistor Q2 in the third pulse output unit 13 can be turned on and the third transistor Q3 and the fourth transistor Q4 can be turned off. At this time, the voltage V P1 is 0V, the voltage V P3is Udc, then the voltage V between the first electrode P1 and the third electrode P3 P1-P3 -Udc. Subsequent V P1-P3 The control method of each stage of Udc is the same as that of the 0~t1 stage, V P1-P3 The control method of each stage of -Udc is the same as that of the t1 to t2 stage, and will not be repeated here.

[0059] Figure 5 Another pulse voltage waveform diagram provided by the embodiment of the present invention is shown in FIG. Figure 2 , Figure 3 and Figure 5 , similarly, each transistor in the second pulse output unit 12 and the fourth pulse output unit 14 is controlled to remain in the off state. In this process, in the process of outputting the pulse voltage signal, the first transistor Q1 and the fourth transistor Q4 in the third pulse output unit 13 can be controlled to always remain in the off state, and the second transistor Q2 and the third transistor Q3 can always remain in the on state. Then, due to the voltage dividing effect of the first capacitor C1 and the second capacitor C2, the voltage of the second node N2 is Udc / 2, and the voltage of the second node N2 can be transmitted to the first node N1 through the third node N3, the first diode D1, and the second transistor Q2 in the third pulse output unit 13, that is, the third pulse output unit 13 always outputs a voltage signal of Udc / 2, and the voltage V at the third electrode P3 end is P3 The voltage outputted by the first node N1 of the first pulse output unit 11 is Udc, and the voltage V at the first electrode P1 is always Udc / 2. P1 is Udc, then the voltage V between the first electrode P1 and the third electrode P3 P1-P3 =Udc / 2. When the first transistor Q1 and the second transistor Q2 in the first pulse output unit 11 are turned off and the third transistor Q3 and the fourth transistor Q4 are turned on during the t3-t4 period, the voltage outputted by the first node N1 of the first pulse output unit 11 is 0V, and the voltage V P1 is 0V, then the voltage V between the first electrode P1 and the third electrode P3 P1-P3 = -Udc / 2. The subsequent V P1-P3 The control method of each stage of Udc / 2 is the same as that of stage 0 to t3. P1-P3 The control method of each stage is the same as that of the stage t3 to t4, and will not be repeated here. Alternatively, the DC voltage provided by the DC voltage terminal VDD can be directly reduced from Udc to Udc / 2, which can also achieve Figure 5The pulse voltage waveform shown can reduce the withstand voltage requirement for the first capacitor C1 and the second capacitor C2, thereby reducing the cost.

[0060] The amplitude of the pulse voltage signal can be adjusted by adjusting the voltage value of the DC voltage terminal VDD, and the pulse width of the pulse voltage signal can be adjusted by controlling the duty cycle of each transistor. In the process of ablation treatment using pulse field ablation, since each electrode P is independently controlled by a pulse output unit 10', when all electrodes release energy for ablation treatment, the two electrodes can be controlled in turn to output pulse voltages in a patrol manner, for example, the first electrode P1 and the third electrode P3 can be controlled in turn to output the first pulse voltage, and the second electrode P2 and the fourth electrode P4 can be controlled to output the second pulse voltage. In this case, each first switch K1 in the first switch module 20 can be controlled to be in the on state, and the corresponding electrode pair can be controlled to output the pulse voltage signal only by controlling the state of each transistor in each pulse output unit 10', which can effectively shorten the response time. And only one electrode pair outputs a pulse voltage signal at the same time, which has a relatively low power supply requirement for the high-voltage power supply, and can reduce the heating of the electrode. Furthermore, since each pulse output unit 10′ in the pulse output module is electrically connected to the same DC voltage terminal VDD, the bus used to transmit the DC voltage signal is always in a charging state. In the process of outputting the pulse voltage waveform in a patrol manner, there is no need to repeatedly charge and discharge the bus voltage due to the different DC voltage terminals VDD connected to each pulse output unit 10′, which can improve the switching rate of the high level and low level of the pulse voltage signal.

[0061] According to tests, the pulse output module 10 can effectively reduce the pulse width of the pulse voltage signal and make the pulse width of the pulse voltage signal less than 100ns.

[0062] When it is determined that the ablation energy is radio frequency energy, the controller 50 can control all the first switches K1 in the first switch module 20 to be in the off state. At this time, the pulse output module 10 cannot output the pulse voltage signal to each electrode P through the first switch module 20. During this period, two of the second switches K2 in the second switch module 30 can be controlled to be in the on state, and the other two second switches K2 can be in the off state. Exemplarily, when the first pulse output unit 11 and the second pulse output unit 12 are controlled to output the pulse voltage signal, the two second switches K2 electrically connected thereto can be controlled to be in the on state, then the pulse voltage signal output by the first pulse output unit 11 can be transmitted to the first power band stop filter 41, and the pulse voltage signal output by the second pulse output unit 12 can be transmitted to the second power band stop filter 42. The first power band stop filter 41 and the second pulse output unit 12 process the received pulse voltage signal so that the voltage between the first electrode P1 and the second electrode P2 presents a sine wave radio frequency signal.

[0063] Based on the same inventive concept, an embodiment of the present invention further provides a control method for an ablation therapy system, which is applied to the ablation therapy system provided by any embodiment of the present invention, can solve the problem of a single ablation method during the treatment process, and can realize the switching of pulse energy and radio frequency energy.

[0064] Figure 6 is a flow chart of a first control method of an ablation therapy system provided by an embodiment of the present invention, such as Figure 6 As shown, the control method of the ablation treatment system includes:

[0065] S110 . During the ablation treatment, obtain current dielectric characteristics of the target biological tissue.

[0066] Specifically, the target biological tissue may be a part of the heart that needs treatment. The dielectric characteristics may be data including signal characteristics such as frequency, phase, amplitude, etc., which can reflect the actual physical morphology of the biological tissue, such as the wall thickness and edema of the biological tissue. In short, the dielectric characteristics have a corresponding relationship with the wall thickness and edema of the biological tissue. The corresponding relationship can be expressed by a formula, and the embodiment of the present invention does not specifically limit this. The target biological tissue will produce a corresponding reaction after receiving the ablation energy, and the reaction can be described by the dielectric characteristics. Based on this, the dielectric characteristics of the target biological tissue can be continuously obtained during the ablation treatment. In a preferred embodiment, the dielectric characteristics of the target biological tissue can be obtained each time the ablation energy is output to the target biological tissue.

[0067] S120, judging whether to continue to output ablation energy according to the dielectric characteristics; if so, executing step S130.

[0068] Specifically, the dielectric characteristics of the target biological tissue after ablation treatment (assuming that it is a preset dielectric characteristic) can be determined based on experience and stored in advance. After obtaining the dielectric characteristics of the target biological tissue, the current dielectric characteristics can be compared with the preset dielectric characteristics. If the current dielectric characteristics are consistent with the preset dielectric characteristics (equal or with a small error), it is determined that the state of the target biological tissue does not need to continue ablation, and a message prompting that the ablation treatment is completed can be output; if the current dielectric characteristics are inconsistent with the preset dielectric characteristics (not equal or with a large difference), it is determined that the ablation energy needs to be continued. In another feasible embodiment, the range of the dielectric characteristics of the target biological tissue after ablation treatment can be pre-stored (assuming that it is a preset characteristic range), and the obtained dielectric characteristics can be matched with the preset characteristic range. If the dielectric characteristics are within the preset characteristic range, it is determined that the state of the target biological tissue does not need to continue ablation, and a message prompting that the ablation treatment is completed can be output; if the current dielectric characteristics are no longer within the preset characteristic range, it is determined that the ablation energy needs to be continued.

[0069] S130. Determine the type of ablation energy according to dielectric characteristics.

[0070] Specifically, the state of the target biological tissue can be determined based on the dielectric characteristics, so that the type of ablation energy that matches the current state of the target biological tissue can be determined. Based on the ablation treatment system provided by the embodiment of the present invention, the types of ablation energy include pulse energy, radio frequency energy, and mixed energy in which pulse energy and radio frequency energy are alternately output. It can be understood that when the electrode pair outputs a pulse voltage signal, the type of ablation energy is pulse energy, and when the electrode pair outputs a radio frequency signal, the type of ablation energy is radio frequency energy.

[0071] Exemplarily, when determining the type of ablation energy based on dielectric characteristics, the biological parameters of the target biological tissue can be first determined based on the dielectric characteristics; then, each preset parameter value of the current treatment stage is obtained; each preset parameter value includes a first preset parameter value, a second preset parameter value and a third preset parameter value; in the same treatment stage, the first preset parameter value is less than the second preset parameter value, and the second preset parameter value is less than the third preset parameter value; finally, the type of ablation energy is determined based on the biological parameters and each preset parameter value.

[0072] Specifically, the biological parameters can be composed of a combination of the wall thickness t (mm) and edema v (ml) that characterize the biological tissue, that is, the wall thickness and edema of the biological tissue can be determined according to the biological parameters. After the ablation energy is output to the biological tissue, the wall thickness and edema of the biological tissue will change, that is, the biological parameters will also change accordingly. The treatment stage can be determined by the number of times the ablation energy is output, and the preset parameter value is set according to the number of times the ablation energy is output. Exemplarily, in the same treatment stage, at least three preset parameter values ​​can be set, and the present invention only exemplarily shows three preset parameter values, but is not limited to this. In the same treatment stage, the size relationship between the first preset parameter value, the second preset parameter value and the third preset parameter value can increase successively. In different treatment stages, as the number of ablation energy outputs increases, each preset parameter value may change accordingly.

[0073] For example, when obtaining the preset parameter values ​​of the current treatment stage, the number of times the ablation energy is output during the current treatment process can be first obtained; then the treatment stage can be determined according to the number; thereby, the preset parameter values ​​corresponding to the treatment stage can be obtained. In a preferred embodiment, the number of times the ablation energy is output can be associated with each preset parameter value and stored for easy acquisition.

[0074] Exemplarily, as the edema of the target biological tissue becomes more and more serious with the increase in the number of ablations, in different treatment stages, as the number of ablation output energy increases, the first preset parameter value may show an increasing trend, the second preset parameter value may show an increasing trend, and the third preset parameter value may show an increasing trend. That is, the first preset parameter value is positively correlated with the number of times, the second preset parameter value is positively correlated with the number of times, and the third preset parameter value is positively correlated with the number of times. In this way, it is possible to more accurately determine whether the state of the target biological tissue is caused by a lesion or by ablation, which is conducive to a more accurate grasp of the ablation process. It can be understood that the first preset parameter value, the second preset parameter value, and the third preset parameter value are all greater than zero. The current biological parameters are compared with the preset parameter values ​​of the current treatment stage to determine the type of ablation energy.

[0075] S140 , controlling the state of the first switch module and the state of the second switch module according to the type of ablation energy.

[0076] When the ablation energy type is pulse energy, the first switch module is controlled to be turned on and the second switch module is turned off; and when the ablation energy type is radio frequency energy, the second switch module is controlled to be turned on and the first switch module is turned off.

[0077] Specifically, combined with reference Figure 1 to Figure 3 In the embodiment, if the ablation energy is determined to be pulse energy, the controller 50 may output a first switch control signal capable of controlling the first switch module 20 to be turned on, and output a second switch control signal capable of controlling the second switch module 30 to be turned off, so that the first switch module 20 is turned on and the second switch module 30 is turned off. At this time, the pulse output module 10 may be controlled to output a voltage signal to two of the electrodes P, so that the voltage between the two electrodes P is in a pulse voltage signal waveform, so that the pulse voltage signal can be output to the target biological tissue through the electrode P, and pulse field ablation can be performed on the target biological tissue.

[0078] If the ablation energy is determined to be radio frequency energy, the controller 50 may output a first switch control signal capable of controlling the first switch module 20 to be disconnected, and output a second switch control signal capable of controlling the second switch module 30 to be turned on, so that the first switch module 20 is disconnected and the second switch module 30 is turned on. At this time, the pulse output module 10 may be controlled to output a pulse voltage signal, and the pulse voltage signal may be transmitted to the radio frequency output module 40, so that the radio frequency output module 40 converts the pulse voltage signal into a radio frequency signal and outputs it to the two electrodes P, so that the voltage between the two electrodes P is a radio frequency signal waveform, preferably a sinusoidal waveform, so that the radio frequency signal can be output to the target biological tissue through the electrode P, and radio frequency ablation of the target biological tissue can be performed.

[0079] The ablation treatment method provided by the embodiment of the present invention continuously obtains the current dielectric characteristics of the target biological tissue during the ablation treatment, so that it can be determined whether to continue the ablation treatment based on the dielectric characteristics. After determining to continue the ablation treatment, the ablation energy is determined based on the dielectric characteristics, so that the state of the first switch module and the state of the second switch module can be controlled according to the ablation energy, so that when the ablation energy is pulse energy, the first switch module is controlled to be turned on and the second switch module is turned off, so that the electrode end outputs a pulse voltage signal to perform pulse field ablation on the target biological tissue, and when the ablation energy is radio frequency energy, the second switch module is controlled to be turned on and the first switch module is turned off, so that the electrode end outputs a radio frequency signal to perform radio frequency ablation on the target biological tissue. During the ablation treatment, appropriate ablation energy can be selected for treatment according to the state of the target biological tissue, making the treatment process more flexible, and while achieving the treatment effect, it is possible to improve the treatment efficiency and reduce the damage to the target biological tissue.

[0080] Optional, Figure 7 is a flow chart of a second control method of an ablation therapy system provided by an embodiment of the present invention. Figure 7 As shown, the control method of the ablation treatment system includes:

[0081] S211. During the ablation treatment, obtain the current dielectric characteristics of the target biological tissue.

[0082] S212, judging whether to continue to output ablation energy according to the dielectric characteristics; if so, executing step S213.

[0083] S213. Determine biological parameters of the target biological tissue according to the dielectric characteristics.

[0084] S214. Obtaining preset parameter values ​​of the current treatment stage.

[0085] Among them, each preset parameter value includes a first preset parameter value, a second preset parameter value and a third preset parameter value; in the same treatment stage, the first preset parameter value is smaller than the second preset parameter value, and the second preset parameter value is smaller than the third preset parameter value.

[0086] S215, determining whether the biological parameter is greater than a third preset parameter value; if so, executing step S216; if not, executing step S217.

[0087] S216. Determine that the type of ablation energy is mixed energy.

[0088] The mixed energy includes pulse energy and radio frequency energy.

[0089] Specifically, if the biological parameter is greater than the third preset parameter value, it means that the wall thickness of the biological tissue is relatively thick, and mixed energy can be used for ablation. When outputting mixed energy, pulse energy can be output first, and then switched to radio frequency energy. This can avoid the problem of long-term use of radio frequency energy for ablation easily causing thermal damage to the target biological tissue, and can avoid the problem of using a single pulse energy for ablation resulting in a long ablation time and complex pulse parameter settings. It can improve the efficiency of ablation treatment of the target biological tissue and shorten the ablation time while achieving the ablation effect.

[0090] S217, determine whether the biological parameter is greater than the second preset parameter value; if so, execute step S218; if not, execute step S219.

[0091] S218. Determine that the type of ablation energy is pulse energy.

[0092] Specifically, if it is determined that the biological parameter is less than or equal to the third preset parameter value and greater than the second preset parameter value, it means that the current wall thickness of the target biological tissue is moderate, the setting range of the pulse parameter is controllable, and the pulse field ablation process will not be too long, which can reduce the impact of muscle contraction. At this time, the ablation energy can be determined as pulse energy, and there is no need to switch energy, so that pulse energy can be used for faster and more accurate ablation.

[0093] S219, determine whether the biological parameter is greater than the first preset parameter value; if so, execute step S220; if not, execute step S218.

[0094] S220. Determine that the type of ablation energy is radiofrequency energy.

[0095] Specifically, if the biological parameter is greater than the first preset parameter value and less than or equal to the second preset parameter value, it is determined that the wall thickness of the target biological tissue is thin at this time, and the ablation energy can be determined to be radio frequency energy, and a more reliable radio frequency ablation is used to achieve ablation of the target biological tissue.

[0096] If it is determined that the biological parameter is less than the first preset parameter value, it means that the wall thickness of the target biological tissue is very thin and is not suitable for radio frequency ablation, which can easily cause thermal perforation. At this time, the ablation energy can be determined to be pulse energy, and the pulse parameters can be set based on the minimum damage degree.

[0097] S221 . Control the state of the first switch module and the state of the second switch module according to the type of ablation energy.

[0098] Optional, Figure 8 is a flow chart of a third control method of an ablation treatment system provided by an embodiment of the present invention. Figure 8 As shown, the control method of the ablation treatment system includes:

[0099] S311. During the ablation treatment, obtain the current dielectric characteristics of the target biological tissue.

[0100] S312, judging whether to continue to output ablation energy according to the dielectric characteristics; if so, executing step S313.

[0101] S313. Determine biological parameters of the target biological tissue according to the dielectric characteristics.

[0102] S314, obtaining various preset parameter values ​​of the current treatment stage.

[0103] Among them, each preset parameter value includes a first preset parameter value, a second preset parameter value and a third preset parameter value; in the same treatment stage, the first preset parameter value is smaller than the second preset parameter value, and the second preset parameter value is smaller than the third preset parameter value.

[0104] S315, determine whether the biological parameter is greater than the third preset parameter value; if so, execute step S316; if not, execute step S317.

[0105] S316. Determine that the type of ablation energy is mixed energy.

[0106] The mixed energy includes pulse energy and radio frequency energy.

[0107] S317, determine whether the biological parameter is greater than the second preset parameter value; if so, execute step S318; if not, execute step S319.

[0108] S318. Determine that the type of ablation energy is pulse energy.

[0109] S319, determine whether the biological parameter is greater than the first preset parameter value; if so, execute step S320; if not, execute step S318.

[0110] S320, obtaining the contact pressure between the catheter and the target biological tissue.

[0111] S321, determine whether the abutment pressure is greater than a first preset pressure; if so, execute step S322; if not, execute step S323.

[0112] S322. Determine that the type of ablation energy is radiofrequency energy.

[0113] Specifically, radiofrequency ablation is a thermal ablation method, which requires the electrode catheter (catheter for short) to be reliably attached to the target biological tissue. If it is determined that the biological parameter is less than or equal to the second preset ablation parameter value and greater than the first preset parameter value, the abutment pressure between the catheter and the target biological tissue can be obtained. If the abutment pressure is greater than the first preset pressure, it means that the catheter and the target biological tissue are attached to each other and can be ablated by radiofrequency energy.

[0114] S323, determine whether the abutment pressure is greater than the second preset pressure; if so, execute step S318; if not, execute step S324.

[0115] S324, outputting a non-attachment alarm prompt message; and returning to execute step S320.

[0116] Wherein, the first preset pressure is greater than the second preset pressure.

[0117] Specifically, if the contact pressure is less than or equal to the first preset pressure and greater than the second preset pressure, it means that the catheter and the target biological tissue are in contact with each other but not stable and reliable. At this time, the type of ablation energy can be determined as pulse energy. If the contact pressure is less than or equal to the second preset pressure, it means that the catheter and the target biological tissue are not in contact. At this time, a non-contact alarm prompt message can be output to prompt the operator to move the catheter position, and the contact pressure between the catheter and the target biological tissue is continuously obtained during this process to continue to determine the type of ablation energy based on the contact pressure. Among them, the second preset pressure is preferably set to zero.

[0118] S325 . Control the state of the first switch module and the state of the second switch module according to the type of ablation energy.

[0119] Optional, Fig. 9 is a flow chart of a fourth control method of an ablation therapy system provided by an embodiment of the present invention. Fig. 9 As shown, the control method of the ablation treatment system includes:

[0120] S411. During the ablation treatment, obtain the current dielectric characteristics of the target biological tissue.

[0121] S412, judging whether to continue to output ablation energy according to the dielectric characteristics; if so, executing step S413.

[0122] S413. Determine biological parameters of the target biological tissue according to the dielectric characteristics.

[0123] S414, obtaining various preset parameter values ​​of the current treatment stage.

[0124] Among them, each preset parameter value includes a first preset parameter value, a second preset parameter value and a third preset parameter value; in the same treatment stage, the first preset parameter value is smaller than the second preset parameter value, and the second preset parameter value is smaller than the third preset parameter value.

[0125] S415, determining whether the biological parameter is greater than a third preset parameter value; if so, executing step S416; if not, executing step S417.

[0126] S416. Determine that the type of ablation energy is mixed energy.

[0127] The mixed energy includes pulse energy and radio frequency energy.

[0128] S417, determine whether the biological parameter is greater than the second preset parameter value; if so, execute step S418; if not, execute step S419.

[0129] S418. Determine that the type of ablation energy is pulse energy.

[0130] S419, determine whether the biological parameter is greater than the first preset parameter value; if so, execute step S420; if not, execute step S418.

[0131] S420: Acquire the contact pressure between the catheter and the target biological tissue.

[0132] S421, determine whether the abutment pressure is greater than a first preset pressure; if so, execute step S422; if not, execute step S425.

[0133] S422. Obtain the temperature of the target biological tissue.

[0134] S423, determine whether the temperature is less than or equal to the preset temperature; if so, execute step S424; if not, execute step S418.

[0135] S424. Determine that the type of ablation energy is radiofrequency energy.

[0136] Specifically, when the type of ablation energy is determined to be radiofrequency energy based on the biological parameters of the target biological tissue and the contact pressure of the catheter, further determination can be made based on the temperature of the target biological tissue to minimize ablation damage. That is, if it is determined that the biological parameter is less than or equal to the second preset parameter value and greater than the first preset parameter value, and the contact pressure between the catheter and the target biological tissue is greater than the first preset pressure, the temperature of the target biological tissue can continue to be obtained. If the temperature of the target biological tissue is less than or equal to the preset temperature, it means that the temperature of the target biological tissue is within a safe range, and radiofrequency energy can be used for ablation, and the type of ablation energy can be determined to be radiofrequency energy. If the temperature of the target biological tissue is greater than the preset temperature, it means that the temperature of the target biological tissue is too high, and it is not appropriate to continue to use radiofrequency energy for ablation, which is likely to cause thermal damage. At this time, the type of ablation energy can be determined to be pulse energy.

[0137] For example, during the ablation treatment, the more times or the longer the radiofrequency ablation is performed, the higher the temperature of the target biological tissue. Therefore, before obtaining the temperature of the target biological tissue, the number of times the ablation energy is output can be obtained first to determine whether the number is greater than or equal to the preset number. If the number is greater than or equal to the preset number, the temperature of the target biological tissue is obtained. If the number is less than the preset number, it means that it is in the initial stage of treatment, and the temperature of the target biological tissue may not be obtained at this time. That is, when the type of ablation energy is determined to be radiofrequency energy based on the biological parameters of the target biological tissue and the contact pressure of the catheter, if the number of times the ablation energy is output is less than the preset number, the type of ablation energy can be directly determined to be radiofrequency energy.

[0138] S425, determining whether the abutment pressure is greater than the second preset pressure; if so, executing step S418; if not, executing step S426.

[0139] S426, outputting a non-attachment alarm prompt message; and returning to execute step S420.

[0140] Wherein, the first preset pressure is greater than the second preset pressure.

[0141] S427 . Control the state of the first switch module and the state of the second switch module according to the type of ablation energy.

[0142] Optional, Fig.10 is a flow chart of a fifth control method of an ablation therapy system provided by an embodiment of the present invention. Fig.10 As shown, the control method of the ablation treatment system includes:

[0143] S511. Output at least two diagnostic pulse voltage signals with different pulse widths to the target biological tissue in sequence.

[0144] Specifically, before controlling the ablation therapy system to perform ablation therapy, the target biological tissue may be diagnosed to detect whether the target biological tissue is a diseased tissue. During diagnosis, at least two diagnostic pulse voltage signals with different pulse widths may be sequentially output to the target biological tissue.

[0145] S512, after each output of the diagnostic pulse voltage signal, obtaining the pulse response spectrum of the target biological tissue.

[0146] S513 , obtaining the maximum dielectric characteristic point according to each pulse response spectrum.

[0147] Specifically, by comparing the pulse response spectra caused by pulse voltage signals of different pulse widths, the spectrum feature corresponding to the frequency point with the largest difference can be determined, and the spectrum feature is determined as the maximum dielectric feature point.

[0148] S514: Output a diagnostic radio frequency signal based on the maximum dielectric characteristic point.

[0149] S515: After outputting the diagnostic radio frequency signal, obtaining biological characteristics of the target biological tissue.

[0150] S516. Determine the biological state of the target biological tissue according to the biological characteristics.

[0151] S517, determine whether the biological state is a pathological state; if so, execute step S518.

[0152] Specifically, after determining the maximum dielectric characteristic point, a radio frequency signal (i.e., a diagnostic radio frequency signal) corresponding to the maximum dielectric characteristic point can be output. After outputting the radio frequency signal, the dielectric characteristics of the target biological tissue are obtained as biological characteristics, so that the biological characteristics can be compared with the biological characteristics of the biological tissue under normal conditions, thereby determining the biological state of the target biological tissue. In this way, ablation treatment can be performed when the biological state is a pathological state, and no ablation treatment can be performed when the biological state is a normal state.

[0153] In another feasible embodiment, the maximum dielectric characteristic point can also be compared with the dielectric characteristics of the target biological tissue under normal conditions to make a preliminary judgment on the biological state of the target biological tissue, and then the biological state of the target biological tissue is determined again based on the biological characteristics after the output radio frequency signal. If the two diagnostic results are both pathological states, the target biological tissue is finally determined to be in a pathological state, which can improve the accuracy of the diagnostic results.

[0154] S518. During the ablation treatment, obtain the current dielectric characteristics of the target biological tissue.

[0155] S519, judging whether to continue to output ablation energy according to the dielectric characteristics; if so, executing step S520.

[0156] S520. Determine the type of ablation energy according to the dielectric characteristics.

[0157] S521 . Control the state of the first switch module and the state of the second switch module according to the type of ablation energy.

[0158] When the ablation energy type is pulse energy, the first switch module is controlled to be turned on and the second switch module is turned off; and when the ablation energy type is radio frequency energy, the second switch module is controlled to be turned on and the first switch module is turned off.

[0159] It should be understood that the various forms of processes shown above can be used to reorder, add or delete steps. For example, the steps described in the present invention can be executed in parallel, sequentially or in different orders, as long as the desired results of the technical solution of the present invention can be achieved, and this document does not limit this.

[0160] The above specific implementations do not constitute a limitation on the protection scope of the present invention. It should be understood by those skilled in the art that various modifications, combinations, sub-combinations and substitutions can be made according to design requirements and other factors. Any modification, equivalent substitution and improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. An ablation therapy system, characterized in that: include: A pulse output module, a first switch module, a second switch module, a radio frequency output module and a controller; The first switch module is electrically connected between the pulse output module and at least two electrodes; the second switch module is electrically connected between the pulse output module and the radio frequency output module, and the radio frequency output module is also electrically connected to at least two electrodes; the controller is electrically connected to the pulse output module, the first switch module and the second switch module respectively; The controller is used to output a pulse control signal to the pulse output module, and output a first switch control signal to the first switch module, and output a second switch control signal to the second switch module; The pulse output module is used to output a pulse voltage signal according to the pulse control signal; The first switch module is used to be turned on or off according to the first switch control signal, and transmit the pulse voltage signal to the electrode when turned on; The second switch module is used to be turned on or off according to the second switch control signal, and transmit the pulse voltage signal provided by the pulse output module to the RF output module when turned on; The radio frequency output module is used to output a radio frequency signal to the electrode according to the pulse voltage signal when receiving the pulse voltage signal; The controller is further configured to: during the ablation treatment, obtain current dielectric characteristics of the target biological tissue; determining whether to continue outputting ablation energy according to the dielectric characteristics; If yes, then determining the type of ablation energy according to the dielectric characteristics; wherein the type of ablation energy includes pulse energy, radio frequency energy, and mixed energy of the pulse energy and the radio frequency energy output alternately; Controlling the state of the first switch module and the state of the second switch module according to the type of the ablation energy; Wherein, when the type of the ablation energy is pulse energy, the first switch module is controlled to be turned on and the second switch module is turned off; and when the type of the ablation energy is radio frequency energy, the second switch module is controlled to be turned on and the first switch module is turned off; The controller is further configured to: when determining the type of ablation energy according to the dielectric characteristics, determine the biological parameters of the target biological tissue according to the dielectric characteristics; obtain each preset parameter value of the current treatment stage; each preset parameter value includes a first preset parameter value, a second preset parameter value and a third preset parameter value; in the same treatment stage, the first preset parameter value is less than the second preset parameter value, and the second preset parameter value is less than the third preset parameter value; determine the type of ablation energy according to the biological parameters and each preset parameter value; The controller is further configured to: when obtaining each preset parameter value of the current treatment stage, obtain the number of times the ablation energy is output during the current treatment process; determine the treatment stage according to the number; and obtain each preset parameter value corresponding to the treatment stage; The first preset parameter value is positively correlated with the number of times, the second preset parameter value is positively correlated with the number of times, and the third preset parameter value is positively correlated with the number of times; The controller is also configured to: before ablation treatment, sequentially output at least two diagnostic pulse voltage signals with different pulse widths to the target biological tissue; after each output of the diagnostic pulse voltage signal, obtain a pulse response spectrum of the target biological tissue; obtain a maximum dielectric feature point based on each of the pulse response spectra; preliminarily determine a biological state of the target biological tissue based on the maximum dielectric feature point; output a diagnostic radio frequency signal based on the maximum dielectric feature point; after outputting the diagnostic radio frequency signal, obtain a biological feature related to the target biological tissue; determine the biological state of the target biological tissue again based on the biological feature; and when it is determined that the biological states determined twice are both pathological states, perform the step of obtaining the current dielectric feature of the target biological tissue during the ablation treatment.

2. The ablation therapy system according to claim 1, characterized in that: The pulse output module includes a plurality of pulse output units, the first switch module includes a first switch corresponding to each of the pulse output units, and the second switch module includes a second switch corresponding to each of the pulse output units; Each of the pulse output units is electrically connected to the controller, and an output end of each of the pulse output units is electrically connected to the corresponding first switch in the first switch module, and an output end of each of the pulse output units is also electrically connected to the corresponding second switch in the second switch module; Each of the first switches is also electrically connected to different electrodes, and each of the second switches is also electrically connected to the radio frequency output module.

3. The ablation therapy system according to claim 2, characterized in that: The pulse output unit includes a first transistor, a second transistor, a third transistor and a fourth transistor; In the same pulse output unit, the first electrode of the first transistor is electrically connected to the DC voltage terminal, and the second electrode of the first transistor is electrically connected to the first electrode of the second transistor; The first electrode of the third transistor and the second electrode of the second transistor are electrically connected to a first node, the first end of the fourth transistor is electrically connected to the second electrode of the third transistor, and the second end of the fourth transistor is electrically connected to the ground end; The control electrode of the first transistor, the control electrode of the second transistor, the control electrode of the third transistor and the control electrode of the fourth transistor are all connected to the controller; The first node is electrically connected to the corresponding first switch in the first switch module, and the first node is also electrically connected to the corresponding second switch in the second switch module.

4. The ablation therapy system according to claim 3, characterized in that: The pulse output module further includes: a first capacitor and a second capacitor; The first capacitor and the second capacitor are connected in series between a DC voltage terminal and a ground terminal; A connection node between the first capacitor and the second capacitor is a second node.

5. The ablation therapy system according to claim 4, characterized in that: The pulse output unit further includes a first diode and a second diode; In the same pulse output unit, the cathode of the first diode is electrically connected to the second electrode of the first transistor and the first electrode of the second transistor; The cathode of the second diode and the anode of the first diode are electrically connected to a third node, and the anode of the second diode is electrically connected to the second electrode of the third transistor and the first electrode of the fourth transistor; The third node of each of the pulse output units is electrically connected to the second node.

6. The ablation therapy system according to claim 2, characterized in that: The radio frequency output module includes a power band-stop filter arranged in one-to-one correspondence with each of the pulse output units; Each of the power band-stop filters is electrically connected to the pulse output unit corresponding to the corresponding second switch.

7. The ablation therapy system according to claim 1, characterized in that: The controller is further configured to: when determining the type of ablation energy according to the biological parameter and each of the preset parameter values, if it is determined that the biological parameter is greater than a third preset parameter value, determine that the type of ablation energy is mixed energy; The mixed energy includes pulse energy and radio frequency energy; If it is determined that the biological parameter is less than or equal to the third preset parameter value and greater than the second preset parameter value, determining that the type of ablation energy is pulse energy; and, if it is determined that the biological parameter is less than or equal to a first preset ablation parameter value, determining that the type of ablation energy is pulsed field ablation; If it is determined that the biological parameter is less than or equal to the second preset ablation parameter value and greater than the first preset parameter value, the type of ablation energy is determined to be radio frequency energy.

8. The ablation therapy system according to claim 7, characterized in that: The controller is further configured to: before determining that the ablation method is radio frequency field ablation, obtain the contact pressure between the catheter and the target biological tissue; Determining whether the abutment pressure is greater than a first preset pressure; If it is determined that the abutment pressure is greater than the first preset pressure, determining that the type of ablation energy is radiofrequency energy; If it is determined that the abutment pressure is less than or equal to the first preset pressure, determining whether the abutment pressure is greater than a second preset pressure; wherein the first preset pressure is greater than the second preset pressure; If yes, determining the type of the ablation energy is the pulse energy; If not, an alarm prompt message indicating that the catheter is not in contact with the target biological tissue is output, and the process returns to the step of obtaining the contact pressure between the catheter and the target biological tissue.

9. The ablation therapy system according to claim 8, characterized in that: The controller is further configured to: before determining that the ablation method is radio frequency field ablation, obtain the temperature of the target biological tissue; Determining whether the temperature is less than or equal to a preset temperature; If yes, determining that the type of the ablation energy is the radio frequency energy; If not, it is determined that the type of the ablation energy is the pulse energy.

10. The ablation therapy system according to claim 8, characterized in that: The controller is further configured to: before obtaining the temperature of the biological tissue, obtain the number of times the ablation energy is output during the current treatment process; Determining whether the number is greater than or equal to a preset number; If yes, then performing the step of obtaining the temperature of the target biological tissue; If not, the step of determining that the type of ablation energy is radiofrequency energy is performed.

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