Pharmaceutical experiment dissolving device

Abstract

The invention discloses a pharmaceutical experiment dissolving device which comprises a base, a rotating disc, a conical dissolving bottle and a fixing part used for fixing the conical dissolving bottle, two connecting columns are fixedly connected to the top of the base, a top plate is fixedly connected to the tops of the two connecting columns, and a stirring mechanism is arranged at the bottom of the top plate; the stirring mechanism comprises a driving motor and two rotating shafts, the output end of the driving motor is fixedly connected with a stirring shaft, the bottom of the stirring shaft is provided with a stirring piece, the exterior of the stirring shaft is fixedly connected with a driving gear, the exteriors of the two rotating shafts are rotatably connected with meshing gears, and the top of the conical dissolving bottle is fixedly connected with two connecting plates; the tops of the two connecting plates are jointly and fixedly connected with an inner gear ring. According to the pharmaceutical experiment dissolving device disclosed by the invention, four stirring blades and a conical dissolving bottle on a rotating disc can rotate in opposite directions by starting a driving motor, so that the dissolving effect of a solid reagent in the conical dissolving bottle is better, and the dissolving efficiency of the pharmaceutical experiment dissolving device is improved.

Description

Technical Field

[0001] The invention relates to the technical field of pharmaceutical experiments, and in particular to a pharmaceutical experiment dissolution device. Background Art

[0002] In clinical pharmaceutical experiments, dissolving solid reagents is a common operating procedure. The current technology is to add solid reagents and dissolving solutions into a conical flask and vibrate the neck of the conical flask to accelerate the dissolution of the solid reagent inside, but this dissolution method is less efficient.

[0003] After searching, the invention patent with Chinese patent number CN105642172A discloses a swing-type pharmaceutical experiment dissolution device, including a support platform, a fixed plate is arranged above the support platform, a fixed rubber sleeve is arranged on the fixed plate, a dissolution bottle is placed on the upper surface of the fixed plate, the body of the dissolution bottle is installed with the fixed rubber sleeve by interference fit, a collar is installed on the bottleneck of the dissolution bottle, the lower surface of the connecting plate is fixedly connected to one end of the rotating shaft, a ball joint is arranged in the middle position of the rotating shaft, the ball joint is installed with the bearing bush, the bearing bush is fixedly connected to the support platform, and the lower surface of the support platform is fixedly connected with a support leg, a turntable is arranged below the support platform, the turntable is connected to the output shaft of the stepping motor by a key, and a matching hole is arranged on the turntable. Compared with the prior art, the invention patent with Chinese patent number CN105642172A can well meet the dissolution requirements of different degrees and improve the efficiency and accuracy of pharmaceutical experiments.

[0004] Although the above-mentioned pharmaceutical experiment dissolution device can make the dissolution bottle swing at different angles to meet different degrees of dissolution requirements, in the actual dissolution process, the above-mentioned pharmaceutical experiment dissolution device cannot quickly and fully dissolve the solid reagent inside the dissolution bottle only by relying on the swinging of the dissolution bottle, resulting in a slower dissolution speed of the solid reagent and prolonging the progress of the pharmaceutical experiment. Summary of the invention

[0005] The purpose of the present invention is to solve the problem in the prior art that the solid reagent inside the dissolution bottle cannot be quickly and fully dissolved, resulting in a slow dissolution speed of the solid reagent, and to propose a pharmaceutical experiment dissolution device.

[0006] In order to achieve the above object, the present invention adopts the following technical solutions:

[0007] A pharmaceutical experiment dissolution device comprises a base, a rotating disk, a conical dissolution bottle placed on the top of the rotating disk, and a fixing member for fixing the conical dissolution bottle, wherein the top of the base is fixedly connected to two connecting columns, and the tops of the two connecting columns are fixedly connected to a top plate;

[0008] The bottom of the top plate is provided with a stirring mechanism for accelerating the dissolution of the solid reagent inside the conical dissolution bottle, the stirring mechanism includes a driving motor fixedly connected to the bottom of the top plate and two rotating shafts, the output end of the driving motor is fixedly connected to the stirring shaft, the bottom of the stirring shaft is provided with a stirring member, the outside of the stirring shaft is fixedly connected to a driving gear, and the outsides of the two rotating shafts are rotatably connected to meshing gears meshing with the driving gears;

[0009] The top of the conical dissolution bottle is fixedly connected to two connecting plates, and the tops of the two connecting plates are commonly fixedly connected to an inner gear ring;

[0010] A driving mechanism for driving the conical dissolution bottle to move up and down is arranged on the top of the base.

[0011] Among them, the driving mechanism can make the stirring piece enter the dissolving liquid inside the conical dissolution bottle, so that the inner side of the inner gear ring is meshed with the outer sides of the two meshing gears; by starting the driving motor, the stirring piece and the conical dissolution bottle on the rotating disk can be rotated in opposite directions, so that the dissolution effect of the solid reagent inside the conical dissolution bottle is better.

[0012] The above technical solution further includes:

[0013] The stirring member comprises a connecting head fixedly connected to the bottom of the stirring shaft, four stirring blades are hingedly connected to the outside of the connecting head, and connecting rods are hingedly connected to the sides of the four stirring blades close to each other.

[0014] The outside of the stirring shaft is slidably connected with a sliding sleeve, one end of the four connecting rods away from the four stirring blades is hinged on the outside of the sliding sleeve, and the upper and lower ends of the sliding sleeve are fixedly connected with electromagnet rings.

[0015] The outside of the stirring shaft is fixedly connected with two iron rings which can be attracted to the two electromagnet rings.

[0016] Among them, when the electromagnet ring at the top of the sliding sleeve is energized and adsorbed with the iron ring above the stirring shaft, the four stirring blades are tightened on the outside of the stirring shaft through four connecting rods; when the electromagnet ring at the bottom of the sliding sleeve is energized and adsorbed with the iron ring below the stirring shaft, the four stirring blades are opened on the outside of the stirring shaft through four connecting rods.

[0017] The driving mechanism includes an electro-hydraulic push rod and two telescopic rods installed on the top of the base. The output ends of the electro-hydraulic push rod and the two telescopic rods are fixedly connected to a connecting disk. An arc-shaped slide groove is provided on the top of the connecting disk. Four sliding shafts are slidably connected inside the arc-shaped slide groove. The ends of the four sliding shafts away from the inside of the arc-shaped slide groove are fixedly connected to the bottom of the rotating disk.

[0018] The telescopic state of the two telescopic rods is consistent with that of the electro-hydraulic push rod; the four sliding shafts are slidably connected inside the arc-shaped slide groove, so that the rotating disk is smoother during the rotation process.

[0019] A controller for controlling the working states of the drive motor, the electromagnet ring and the electro-hydraulic push rod is arranged on the top of the top plate.

[0020] A clamping groove matched with the clamping plate is provided on the top of the rotating disk, and a limiting component for limiting the rotation of the rotating disk is provided on the bottom of the connecting disk.

[0021] Wherein, the clamping slot is a rectangular clamping slot.

[0022] The limiting assembly includes an L-shaped connecting plate fixedly connected to the bottom of the connecting plate, the top of the L-shaped connecting plate is fixedly connected to the limiting plate, a damping sleeve is arranged on the outer side of the L-shaped connecting plate, and the outside of the damping sleeve is fixedly connected to a clamping plate which can be clamped in the inside of the clamping groove.

[0023] There is a certain damping feeling between the inner side of the damping sleeve and the outer side of the damping sleeve.

[0024] The present invention has the following beneficial effects:

[0025] 1. In the present invention, the stirring member is caused to enter the dissolved liquid inside the conical dissolution bottle by starting the electro-hydraulic push rod, so that the inner side of the inner gear ring is meshed with the outer sides of the two meshing gears, and then the electromagnet ring at the top of the sliding sleeve is powered off and the electromagnet ring at the bottom of the sliding sleeve is powered on, so that the electromagnet ring at the bottom of the sliding sleeve is adsorbed with the iron ring below the stirring shaft, so that the four stirring blades are fully opened on the outside of the stirring shaft, and then the driving motor is started to make the four stirring blades rotate and stir the solid reagent and dissolved liquid inside the conical dissolution bottle, and at the same time, the inner gear ring drives the rotating disk and the conical dissolution bottle on the rotating disk to rotate in the direction opposite to the rotation direction of the four stirring blades through the two connecting plates, so that the solid reagent dissolution effect inside the conical dissolution bottle is better, thereby improving the dissolution efficiency of the pharmaceutical experiment dissolution device.

[0026] 2. In the present invention, the damping sleeve is slid downward to drive the clamping plate to move toward the clamping groove on the rotating disk until the clamping plate is completely clamped inside the clamping groove. At this time, the rotating disk cannot rotate, thereby preventing the rotating disk from rotating during the process of fixing the conical dissolution bottle and affecting the fixing operation of the conical dissolution bottle. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 This is a first structural schematic diagram of a pharmaceutical experimental dissolution device proposed by the present invention;

[0028] Figure 2 for Figure 1 A schematic diagram of the structure enlargement in the middle;

[0029] Figure 3 for Figure 1 A magnified schematic diagram of the structure at B in the middle;

[0030] Figure 4 for Figure 1 A magnified schematic diagram of the structure at C in the middle;

[0031] Figure 5 It is a schematic diagram of the structure of the fixing member and the driving mechanism in the present invention;

[0032] Figure 6 for Figure 5 A magnified schematic diagram of the structure at D in the middle;

[0033] Figure 7 This is a second structural schematic diagram of a pharmaceutical experimental dissolution device proposed by the present invention.

[0034] In the figure: 1, base; 2, rotating disk; 3, conical dissolving bottle; 4, fixing piece; 41, transparent fixing rubber sleeve; 42, rubber sleeve ring; 43, fastening belt 43; 5, connecting column; 6, top plate; 7, stirring mechanism; 71, driving motor; 72, rotating shaft; 73, stirring shaft; 74, stirring piece; 741, connecting head; 742, stirring blade; 743, connecting rod; 75, driving gear; 76, meshing Gear; 77, sliding sleeve; 78, electromagnet ring; 79, iron ring; 8, connecting plate; 9, inner gear ring; 10, driving mechanism; 101, electro-hydraulic push rod; 102, telescopic rod; 103, receiving plate; 104, arc-shaped slide groove; 105, shaft; 11, controller; 12, snap-in groove; 13, limit assembly; 131, L-shaped connecting plate; 132, limit plate; 133, damping sleeve; 134, snap-in plate. DETAILED DESCRIPTION

[0035] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0036] Embodiment 1

[0037] like Figure 1-3 and Figure 5-7As shown, a pharmaceutical experiment dissolution device proposed by the present invention comprises a base 1, a rotating disk 2, a conical dissolution bottle 3 placed on the top of the rotating disk 2, and a fixing member 4 for fixing the conical dissolution bottle 3, wherein the fixing member 4 comprises a transparent fixed rubber sleeve 41 arranged in the middle of the rotating disk 2, the bottle body of the conical dissolution bottle 3 is installed with an interference fit with the transparent fixed rubber sleeve 41, and the bottleneck of the conical dissolution bottle 3 is fitted with a rubber sleeve 42, and four connecting holes are provided on the rubber sleeve 42, and the inside of the four connecting holes are all connected with a fastening belt 43 fixedly connected to the top of the rotating disk 2 through a chain buckle, and the stability of the conical dissolution bottle 3 on the rotating disk 2 can be ensured by the transparent fixed rubber sleeve 41 and the four fastening belts 43, and two connecting columns 5 are fixedly connected to the top of the two connecting columns 5, and a top plate 6 is fixedly connected to the top of the top plate 6, and a controller 11 for controlling the working state of the driving motor 71, the electromagnet ring 78 and the electro-hydraulic push rod 101 is provided on the top of the top plate 6;

[0038] A stirring mechanism 7 for accelerating the dissolution of the solid reagent in the conical dissolution bottle 3 is provided at the bottom of the top plate 6. The stirring mechanism 7 includes a driving motor 71 and two rotating shafts 72 fixedly connected to the bottom of the top plate 6. The output end of the driving motor 71 is fixedly connected to a stirring shaft 73. A stirring member 74 is provided at the bottom of the stirring shaft 73. The stirring member 74 includes a connector 741 fixedly connected to the bottom of the stirring shaft 73. Four stirring blades 742 are hingedly connected to the outside of the connector 741. The sides of the four stirring blades 742 close to each other are hingedly connected to connecting rods 743. A sliding sleeve 77 is slidably connected to the outside of the stirring shaft 73. One end of the four connecting rods 743 away from the four stirring blades 742 is hinged to the outside of the sliding sleeve 77. The upper and lower ends of the sliding sleeve 77 are fixedly connected to an electromagnet ring 78. The outside of the stirring shaft 73 is fixedly connected to two iron rings 79 that can be adsorbed by the two electromagnet rings 78.

[0039] When the electromagnet ring 78 at the top of the sliding sleeve 77 is energized (and the electromagnet ring 78 at the bottom of the sliding sleeve 77 is de-energized) and is attracted to the iron ring 79 above the stirring shaft 73, the four stirring blades 742 are tightened on the outside of the stirring shaft 73 through the four connecting rods 743; when the electromagnet ring 78 at the bottom of the sliding sleeve 77 is energized (and the electromagnet ring 78 at the top of the sliding sleeve 77 is de-energized) and is attracted to the iron ring 79 below the stirring shaft 73, the four stirring blades 742 are opened on the outside of the stirring shaft 73 through the four connecting rods 743;

[0040] The outside of the stirring shaft 73 is fixedly connected with a driving gear 75, and the outsides of the two rotating shafts 72 are rotatably connected with meshing gears 76 meshing with the driving gear 75. The top of the conical dissolution bottle 3 is fixedly connected with two connecting plates 8, and the tops of the two connecting plates 8 are fixedly connected with an inner gear ring 9.

[0041] A driving mechanism 10 for driving the conical dissolving bottle 3 to move up and down is arranged on the top of the base 1, and the driving mechanism 10 comprises an electro-hydraulic push rod 101 and two telescopic rods 102 installed on the top of the base 1, and the telescopic state of the two telescopic rods 102 is consistent with that of the electro-hydraulic push rod 101, and the output ends of the electro-hydraulic push rod 101 and the two telescopic rods 102 are fixedly connected with a connecting disk 103, and an arc-shaped slide groove 104 is provided on the top of the connecting disk 103, and four sliding shafts 105 are slidably connected inside the arc-shaped slide groove 104, and the ends of the four sliding shafts 105 away from the inside of the arc-shaped slide groove 104 are fixedly connected with the bottom of the rotating disk 2;

[0042] The four sliding shafts 105 are slidably connected inside the arc-shaped sliding groove 104, so that the rotating disk 2 can rotate more smoothly.

[0043] In this embodiment, the conical dissolution bottle 3 is first fixed by the fixing member 4, and then the solid reagent to be dissolved and the dissolving liquid are added into the conical dissolution bottle 3, and then the bottle stopper is removed from the bottle mouth of the conical dissolution bottle 3, and then the electro-hydraulic push rod 101 is started, so that the connecting disk 103 drives the rotating disk 2 to move upward through the four sliding shafts 105 until the stirring member 74 enters the dissolving liquid inside the conical dissolution bottle 3. When the stirring member 74 enters the dissolving liquid inside the conical dissolution bottle 3, the rotating disk 2 drives the inner gear ring 9 upward to the outer sides of the two meshing gears 76 through the two connecting plates 8, and at this time, the inner side of the inner gear ring 9 is meshed with the outer sides of the two meshing gears 76;

[0044] Subsequently, the controller 11 is used to de-energize the electromagnet ring 78 at the top of the sliding sleeve 77 and energize the electromagnet ring 78 at the bottom of the sliding sleeve 77, so that the electromagnet ring 78 at the bottom of the sliding sleeve 77 drives the sliding sleeve 77 to slide downward close to the iron ring 79 below the stirring shaft 73. In the process of the sliding sleeve 77 sliding downward, the four stirring blades 742 are gradually opened through the four connecting rods 743. When the electromagnet ring 78 at the bottom of the sliding sleeve 77 is attracted to the iron ring 79 below the stirring shaft 73, the four stirring blades 742 are completely opened on the outside of the stirring shaft 73 through the four connecting rods 743 (the controller 11 is used to energize the electromagnet ring 78 at the top of the sliding sleeve 77 and de-energize the electromagnet ring 78 at the bottom of the sliding sleeve 77, so that the electromagnet ring 78 at the top of the sliding sleeve 77 is attracted to the iron ring 79 above the stirring shaft 73, so that the four stirring blades 742 are completely tightened on the outside of the stirring shaft 73 through the four connecting rods 743);

[0045] Then, the driving motor 71 is started through the controller 11, so that the stirring shaft 73 drives the four stirring blades 742 through the connector 741 to rotate and stir the solid reagent and the dissolved liquid in the conical dissolution bottle 3, and at the same time, the stirring shaft 73 drives the two meshing gears 76 to rotate through the driving gear 75, so that the inner gear ring 9 meshing with the outer sides of the two meshing gears 76 keeps rotating in the direction opposite to the rotation direction of the driving gear 75, and the inner gear ring 9 drives the rotating disk 2 and the conical dissolution bottle 3 on the rotating disk 2 to keep rotating in the direction opposite to the rotation direction of the four stirring blades 742 through the two connecting plates 8;

[0046] By starting the driving motor 71, the pharmaceutical experiment dissolution device can make the four stirring blades 742 and the conical dissolution bottle 3 on the rotating disk 2 rotate in opposite directions, so that the solid reagent inside the conical dissolution bottle 3 is better dissolved, thereby improving the dissolution efficiency of the pharmaceutical experiment dissolution device.

[0047] Embodiment 2

[0048] like Figure 1 and Figure 4-7 As shown, based on the first embodiment, a clamping groove 12 adapted to the clamping plate 14 is provided on the top of the rotating disk 2, and the clamping groove 12 is a rectangular clamping groove;

[0049] A limit assembly 13 for limiting the rotation of the rotating disk 2 is provided at the bottom of the connecting disk 103. The limit assembly 13 includes an L-shaped connecting plate 131 fixedly connected to the bottom of the connecting disk 103. The top of the L-shaped connecting plate 131 is fixedly connected to a limit plate 132. A damping sleeve 133 is provided on the outer side of the L-shaped connecting plate 131. There is a certain damping sense between the inner side of the damping sleeve 133 and the outer side of the damping sleeve 133. The outer side of the damping sleeve 133 is fixedly connected to a clamping plate 134 that can be clamped in the clamping groove 12.

[0050] In this embodiment, when the conical dissolution bottle 3 needs to be fixed by the fixing member 4, the damping sleeve 133 is slid downward so that the damping sleeve 133 drives the clamping plate 134 to move toward the clamping groove 12 on the rotating disk 2 until the clamping plate 134 is completely clamped in the clamping groove 12. At this time, the rotating disk 2 cannot rotate, so that the conical dissolution bottle 3 can be fixed by the fixing member 4.

[0051] Fix the conical dissolving bottle 3 by the fixing member 4, and slide the damping sleeve 133 upward to reset the clamping plate 134;

[0052] The pharmaceutical experiment dissolution device enables the clamping plate 134 to be clamped inside the clamping groove 12 through the lower sliding damping sleeve 133, thereby preventing the rotating disk 2 from rotating during the process of fixing the conical dissolution bottle 3 and affecting the fixing operation of the conical dissolution bottle 3.

[0053] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A pharmaceutical experiment dissolution device, comprising a base (1), a rotating disk (2), a conical dissolution bottle (3) placed on the top of the rotating disk (2), and a fixing member (4) for fixing the conical dissolution bottle (3), wherein the top of the base (1) is fixedly connected to two connecting columns (5), and the tops of the two connecting columns (5) are fixedly connected to a top plate (6) together, Features: The bottom of the top plate (6) is provided with a stirring mechanism (7) for accelerating the dissolution of the solid reagent inside the conical dissolution bottle (3), the stirring mechanism (7) comprising a driving motor (71) fixedly connected to the bottom of the top plate (6) and two rotating shafts (72), the output end of the driving motor (71) is fixedly connected to a stirring shaft (73), the bottom of the stirring shaft (73) is provided with a stirring member (74), the outside of the stirring shaft (73) is fixedly connected to a driving gear (75), and the outsides of the two rotating shafts (72) are both rotatably connected to meshing gears (76) meshing with the driving gear (75); Two connecting plates (8) are fixedly connected to the top of the conical dissolution bottle (3), and an inner tooth ring (9) is fixedly connected to the tops of the two connecting plates (8); A driving mechanism (10) for driving the conical dissolution bottle (3) to move up and down is arranged on the top of the base (1).

2. A pharmaceutical experimental dissolution device according to claim 1, It is characterized in that The stirring member (74) comprises a connecting head (741) fixedly connected to the bottom of the stirring shaft (73), four stirring blades (742) are hingedly connected to the outside of the connecting head (741), and a connecting rod (743) is hingedly connected to the sides of the four stirring blades (742) that are close to each other.

3. A pharmaceutical experimental dissolution device according to claim 2, It is characterized in that The outside of the stirring shaft (73) is slidably connected to a sliding sleeve (77), one end of the four connecting rods (743) away from the four stirring blades (742) is hinged to the outside of the sliding sleeve (77), and the upper and lower ends of the sliding sleeve (77) are fixedly connected to electromagnet rings (78).

4. A pharmaceutical experimental dissolution device according to claim 3, It is characterized in that Two iron rings (79) that can be attracted to the two electromagnet rings (78) are fixedly connected to the outside of the stirring shaft (73).

5. A pharmaceutical experimental dissolution device according to claim 3, It is characterized in that The driving mechanism (10) comprises an electro-hydraulic push rod (101) and two telescopic rods (102) mounted on the top of the base (1); the output ends of the electro-hydraulic push rod (101) and the two telescopic rods (102) are fixedly connected to a connecting disk (103); an arc-shaped slide groove (104) is provided on the top of the connecting disk (103); four sliding shafts (105) are slidably connected inside the arc-shaped slide groove (104); and the ends of the four sliding shafts (105) away from the inside of the arc-shaped slide groove (104) are fixedly connected to the bottom of the rotating disk (2).

6. A pharmaceutical experimental dissolution device according to claim 5, It is characterized in that A controller (11) for controlling the working states of the drive motor (71), the electromagnet ring (78) and the electro-hydraulic push rod (101) is arranged on the top of the top plate (6).

7. A pharmaceutical experimental dissolution device according to claim 5, It is characterized in that The top of the rotating disk (2) is provided with a clamping groove (12) adapted to the clamping plate (14), and the bottom of the connecting disk (103) is provided with a limiting component (13) for limiting the rotation of the rotating disk (2).

8. A pharmaceutical experimental dissolution device according to claim 7, It is characterized in that The limiting assembly (13) comprises an L-shaped connecting plate (131) fixedly connected to the bottom of the connecting plate (103), the top of the L-shaped connecting plate (131) being fixedly connected to a limiting plate (132), a damping sleeve (133) being arranged on the outside of the L-shaped connecting plate (131), and a clamping plate (134) which can be clamped into the inside of the clamping groove (12) being fixedly connected to the outside of the damping sleeve (133).

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