Magnetic resonance coil device for detecting analytes in test tubes

Abstract

The present application relates to the field of magnetic resonance technology, and in particular to a magnetic resonance coil device for detecting an analyte in a test tube. The magnetic resonance coil device comprises: a container, the container having a holding cavity for holding a liquid and a socket connected to the holding cavity, the socket being used for inserting the test tube, and the analyte in the test tube being at least partially surrounded by the liquid; a coil, the coil being mounted to the container, and at least a portion of each of the liquid, the test tube, and the analyte being surrounded by the coil. According to the magnetic resonance coil device provided by the present application, the analyte in the test tube is subjected to magnetic resonance scanning in a liquid environment rather than an air environment, which helps to suppress the magnetic susceptibility artifact at the boundary position of the analyte, and further helps to accurately analyze and study the analyte.

Description

Technical Field

[0001] The present application relates to the field of magnetic resonance technology, and in particular to a magnetic resonance coil device for detecting an analyte in a test tube. Background Art

[0002] The magnetic resonance coil device can cooperate with other equipment (eg, a magnetic resonance main magnet, etc.) to perform magnetic resonance imaging detection on certain analytes (eg, magnetic resonance contrast agents) stored in a test tube, so as to analyze and study relevant parameters of the analytes.

[0003] When the analyte is subjected to magnetic resonance scanning imaging, there is a large amount of air at the surface boundary of the test tube, which makes the magnetic susceptibility difference of the air-test tube interface in this area large, and is prone to obvious magnetic susceptibility artifacts. Moreover, the magnetic susceptibility artifacts are likely to extend to the boundary position of the analyte, causing the constructed magnetic resonance image to be obviously blurred and deformed at the boundary of the analyte. In addition, the volume and diameter of the test tube and the volume of the analyte are usually small, so the aforementioned magnetic susceptibility artifacts account for a large area in the magnetic resonance image of the analyte, which significantly affects the accurate analysis of the analyte. Summary of the invention

[0004] In view of this, the present application provides a magnetic resonance coil device for detecting an analyte in a test tube.

[0005] The present application provides a magnetic resonance coil device for detecting an analyte in a test tube, comprising:

[0006] A container, the container having a receiving cavity for receiving a liquid and a socket communicating with the receiving cavity, the socket being used for inserting the test tube, and the analyte in the test tube is at least partially surrounded by the liquid;

[0007] A coil is mounted to the container and at least a portion of each of the liquid, the cuvette, and the analyte is surrounded by the coil.

[0008] In some possible embodiments, the container comprises:

[0009] a container body having an opening;

[0010] a cover, the cover detachably covering the opening and defining the socket;

[0011] Wherein, the container body and the cover jointly define the accommodating cavity.

[0012] In some possible implementations, the cover has a sealed installation space, and the coil is configured in the installation space.

[0013] In some possible implementations, the cover includes a support tube extending in the insertion direction of the test tube, and the coil is disposed around the support tube and supported by the support tube.

[0014] In some possible implementations, the cover includes:

[0015] An upper cover body, wherein the upper cover body defines the socket;

[0016] The lower cover body is detachably mounted to the upper cover body to form the mounting space therebetween, and the lower cover body includes the supporting tube.

[0017] In some possible implementations, the cover has a flat lower surface extending into the accommodating cavity and in contact with the liquid, and the supporting tube extends and terminates at the flat lower surface.

[0018] In some possible implementations, the cover includes a protruding tongue extending out of the opening when viewed from the opening, and the container body includes a pressing tongue rotatably arranged at the opening, and the pressing tongue has a pressing position and an avoiding position by rotating;

[0019] In the pressed position, the pressing tongue presses the protruding tongue toward the container body, thereby preventing the cover from being separated from the opening;

[0020] In the escape position, the depressing tongue is separated from the protruding tongue, thereby allowing the cover to be removed from the opening.

[0021] In some possible implementations, the socket and the coil are respectively configured in plurality.

[0022] In some possible implementations, the plurality of sockets are arranged into a plurality of columns spaced apart from each other along a first direction, and the sockets in each column are spaced apart from each other along a second direction perpendicular to the first direction, but in different arrangement manners.

[0023] In some possible implementations, the device further includes: a preamplifier, wherein the preamplifier is connected to the coil via a conductive cable in a manner separated from the container.

[0024] According to the magnetic resonance coil device provided in the present application, the analyte in the test tube is subjected to magnetic resonance scanning in a liquid environment rather than an air environment, which helps to suppress magnetic susceptibility artifacts at the boundary position of the analyte, thereby facilitating accurate analysis and research of the analyte. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings of the embodiments will be briefly introduced below. Obviously, the drawings in the following description only relate to some embodiments of the present application, rather than limiting the present application.

[0026] Figure 1 It is a three-dimensional schematic diagram of a magnetic resonance coil device provided in an embodiment of the present application.

[0027] Figure 2 yes Figure 1 A schematic plan view of the magnetic resonance coil device in the top view, wherein the tongue depressor is in the pressed position.

[0028] Figure 3 yes Figure 1 A schematic cross-sectional view of the magnetic resonance coil device is shown in FIG. 1 , wherein the cross-section is perpendicular to the second direction.

[0029] Figure 4 yes Figure 1 The cross-sectional schematic diagram of the magnetic resonance coil device in use, the cross-section is perpendicular to the second direction, and for clarity of the drawing, only one test tube is shown.

[0030] Figure 5 yes Figure 1 FIG. 1 is a schematic cross-sectional view of the magnetic resonance coil device in use, wherein the cross section is perpendicular to the second direction and only one test tube is shown for clarity of the drawing.

[0031] Figure 6 yes Figure 1 A schematic plan view of the magnetic resonance coil device in the top view, wherein the tongue depressor is rotated to the avoidance position.

[0032] Description of reference numerals:

[0033] DR1-first direction, DR2-second direction;

[0034] 1-container, 1a-accommodation chamber;

[0035] 2- coil;

[0036] 3-container body, 3a-opening;

[0037] 4-cover, 4a-installation space, 4b-tab;

[0038] 5-upper cover, 5a-socket;

[0039] 6-lower cover body, 6a-support cylinder;

[0040] 7- Conductive cable;

[0041] 8-Tongue depression;

[0042] 9- Preamplifier;

[0043] 10-test tube;

[0044] 11-analyte, 11a-liquid level of analyte;

[0045] 12-liquid, 12a-liquid surface. DETAILED DESCRIPTION

[0046] In order to make the purpose, technical scheme and advantages of the present application clearer, the technical scheme of the embodiment of the present application will be clearly and completely described below in conjunction with the drawings of the embodiment of the present application. Obviously, the described embodiment is a part of the embodiment of the present application, rather than all the embodiments. Based on the described embodiment of the present application, all other embodiments obtained by ordinary technicians in this field without creative work belong to the scope of protection of this application. It can be understood that, in the absence of conflict, some technical means of the various embodiments described herein can be replaced or combined with each other.

[0047] In the description of the specification and claims of this application, if there are terms such as "first", "second", etc., they are only used to distinguish the objects described and do not have any order or technical meaning. Therefore, the objects defined as "first", "second", etc. may explicitly or implicitly include one or more of the objects. In addition, "one" or "a" and similar words do not indicate a quantitative limitation, but indicate the existence of at least one, and "multiple" means no less than two.

[0048] Figures 1 to 6 A magnetic resonance coil device (hereinafter, sometimes referred to as the device) provided according to an embodiment of the present application is shown, which is used to detect an analyte 11 in a test tube 10. Specifically, the device can perform magnetic resonance imaging detection on the analyte 11 in the test tube 10 to study relevant parameters or properties of the analyte 11. The analyte 11 may be, for example, a liquid magnetic resonance contrast agent.

[0049] The device mainly comprises a container 1, a coil 2, a preamplifier 9 protected by a plastic shell, and a conductive cable 7 connecting the coil 2 and the preamplifier 9.

[0050] The container 1 has a receiving chamber 1a for receiving a liquid 12 and a socket 5a connected to the receiving chamber 1a, wherein the socket 5a is used for inserting a test tube 10, and the analyte 11 in the test tube 10 is at least partially surrounded by the liquid 12. Figure 4 In the embodiment, the analyte 11 in the test tube 10 is completely surrounded by the liquid 12, while in Figure 5 In the embodiment, the analyte 11 in the test tube 10 is only partially surrounded by the liquid 12. The liquid 12 may be pure water.

[0051] The coil 2 is mounted to the container 1, and the coil 2 is fluidically isolated from the aforementioned liquid 12. In addition, at least a portion of each of the aforementioned liquid 12, the test tube 10, and the analyte 11 is surrounded by the coil 2. The coil 2 is a radio frequency receiving coil capable of receiving magnetic resonance signals.

[0052] With such a design, the analyte 11 in the test tube 10 will be subjected to magnetic resonance scanning in a liquid 12 environment (such as a pure water environment) rather than an air environment, which helps to suppress magnetic susceptibility artifacts at the boundary of the analyte 11 and further helps to accurately analyze and study the analyte 11.

[0053] Furthermore, the aforementioned sockets 5a and coils 2 are both configured in plurality, and the plurality of sockets 5a are arranged spaced apart from each other. In this embodiment, the number of coils 2 is the same as the number of sockets 5a, and one socket 5a corresponds to one coil 2. In this way, the device can simultaneously perform magnetic resonance detection on analytes 11 in a plurality of test tubes 10. In other embodiments, one socket 5a may correspond to at least two coils 2.

[0054] Regarding the coil 2 corresponding to each socket 5a, in this embodiment, as Figures 3 to 5 As shown, the coil 2 is a single coil unit extending in a circular shape around the periphery of the test tube 10; in other embodiments, the coil 2 may be an array coil composed of at least two coil units, and the individual coil units in the array coil may be arranged around the test tube 10 into a closed circular array.

[0055] The container 1 includes a container body 3 and a cover 4. The container body 3 has a substantially rectangular opening 3a facing upward. The cover 4 detachably covers the opening 3a and defines the insertion opening 5a. In addition, the container body 3 and the cover 4 together define the accommodating chamber 1a.

[0056] Furthermore, the aforementioned cover 4 includes an upper cover body 5 and a lower cover body 6, and the upper cover body 5 and the lower cover body 6 are connected by Figure 1 The screws shown but not labeled are detachably mounted together, and form a sealed mounting space 4a between the upper cover 5 and the lower cover 6, and the coil 2 and the electronic device electrically coupled to the coil 2 (such as a PCB board equipped with the capacitor 1) are arranged in the mounting space 4a. In this way, the solution in the accommodating chamber 1a and the analyte 11 in the test tube 10 can be prevented from contacting the coil 2 and the electronic device, so that the coil 2 and the electronic device are well protected.

[0057] The cover 4 includes a support tube 6a extending in the insertion direction of the test tube 10. The coil 2 is arranged around the support tube 6a and is supported and positioned by the support tube 6a. In this way, the internal space of the support tube 6a constitutes a part of the accommodating chamber 1a. When a sufficient amount of the aforementioned liquid 12 is contained in the accommodating chamber 1a, a part of the liquid 12 will enter the internal space of the support tube 6a and be surrounded by the coil 2. At the same time, the test tube 10 also extends into the internal space of the support tube 6a, so that at least a part of the analyte 11 is surrounded by the liquid 12 in the internal space.

[0058] Specifically, the aforementioned support tube 6a is integrally formed on the lower cover 6, and the aforementioned socket 5a is integrally formed on the upper cover 5. When the upper cover 5 and the lower cover 6 are assembled with each other, the upper end of the support tube 6a is connected to the lower cover 6 via the upper cover 5a. Figures 3 to 5 A rubber sealing ring (not shown but with reference numerals omitted) is sealingly abutted against the periphery of the socket 5a, thereby forming the aforementioned installation space 4a isolated from the socket 5a.

[0059] In addition, the cover 4 has a flat lower surface extending into the accommodating chamber 1a and in contact with the aforementioned liquid 12, and the support tube 6a extends and terminates at the flat lower surface. Through such a design, on the one hand, it helps to increase the aforementioned installation space 4a to facilitate the installation of the coil 2 and electronic components, and on the other hand, it helps to save the amount of liquid 12. Even if a relatively small amount of liquid 12 is used, it can ensure that the liquid 12 has a relatively high liquid level in the support tube 6a.

[0060] The cover 4 includes two protruding tongues 4b extending out of the opening 3a when viewed from the opening 3a, and the container body 3 includes two pressing tongues 8 rotatably arranged at the opening 3a, and the pressing tongues 8 have a pressing position and an escape position by rotating. In the pressing position, the pressing tongue 8 presses the protruding tongue 4b toward the container body 3, thereby preventing the cover 4 from being separated from the opening 3a; in the escape position, the pressing tongue 8 is separated from the protruding tongue 4b, thereby allowing the cover 4 to be separated from the opening 3a.

[0061] In this embodiment, the plurality of sockets 5a are arranged in three columns spaced apart from each other along the first direction DR1. The sockets 5a in each column are spaced apart from each other along the second direction DR2 perpendicular to the first direction DR1, but the arrangement of each column is different - specifically, as shown in FIG. Figure 2 As shown, the first column includes six sockets 5a, which are evenly arranged along the second direction DR2 at equal intervals; the second column includes five sockets 5a, and the fourth and fifth sockets 5a of the five sockets 5a are separated by a larger interval; the third column includes five sockets 5a, and the third and fourth sockets 5a of the five sockets 5a are separated by a larger interval. With such a design, the magnetic resonance images of the analyte 11 in the test tube 10 at different positions can be easily distinguished.

[0062] In addition, if Figure 1 He Ru Figure 2 As shown, the preamplifier 9 is connected to the coil 2 via a conductive cable 7 in a manner separated from the container 1 , so as to better separate the preamplifier 9 from the liquid 12 .

Claims

1. A magnetic resonance coil device for detecting an analyte in a test tube, characterized in that: include: A container, the container having a receiving cavity for receiving a liquid and a socket communicating with the receiving cavity, the socket being used for inserting the test tube, and the analyte in the test tube is at least partially surrounded by the liquid; A coil is mounted to the container and at least a portion of each of the liquid, the cuvette, and the analyte is surrounded by the coil.

2. The device according to claim 1, characterized in that The container comprises: a container body having an opening; a cover, the cover detachably covering the opening and defining the socket; Wherein, the container body and the cover jointly define the accommodating cavity.

3. The device according to claim 2, characterized in that The cover has a sealed installation space, and the coil is arranged in the installation space.

4. The device according to claim 3, characterized in that The cover includes a support tube extending in the insertion direction of the test tube, and the coil is disposed around the support tube and supported by the support tube.

5. The device according to claim 4, characterized in that The cover comprises: An upper cover body, wherein the upper cover body defines the socket; The lower cover body is detachably mounted to the upper cover body to form the mounting space therebetween, and the lower cover body includes the supporting cylinder.

6. The device according to claim 5, characterized in that The cover has a flat lower surface extending into the accommodating cavity and in contact with the liquid, and the supporting tube extends and terminates at the flat lower surface.

7. The device according to claim 2, characterized in that The cover includes a protruding tongue extending out of the opening when viewed from the opening, and the container body includes a pressing tongue rotatably arranged at the opening, the pressing tongue having a pressing position and an avoiding position by rotation; In the pressed position, the pressing tongue presses the protruding tongue toward the container body, thereby preventing the cover from being separated from the opening; In the escape position, the depressing tongue is separated from the protruding tongue, thereby allowing the cover to be removed from the opening.

8. The device according to any one of claims 1 to 7, characterized in that The socket and the coil are respectively configured in plurality.

9. The device according to claim 8, characterized in that The plurality of sockets are arranged into a plurality of columns spaced apart from each other along a first direction, and the sockets in each column are spaced apart from each other along a second direction perpendicular to the first direction, but in different arrangement modes.

10. The device according to any one of claims 1 to 7, characterized in that Also includes: A preamplifier is connected to the coil via a conductive cable in a manner spaced apart from the container.

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