A mass spectrometer detection reagent sample injection processing device

Abstract

The invention discloses a mass spectrometer detection reagent sample injection processing device, which relates to the field of reagent processing, including a processing container. A stirring assembly is arranged below the processing container, the stirring assembly includes a stirrer and two stirring magnets, the two stirring magnets are located below the processing container, the stirrer is located in the processing container, and the stirring magnet can rotate; a retrieving assembly is arranged on the top of the processing container, and a cleaning assembly is also arranged on one side of the processing container, the retrieving assembly can move the stirrer in the processing container into the cleaning assembly, and the cleaning assembly can spray and clean the stirrer inside. The stirrer is taken out by adsorption, the efficiency and stability of taking out the stirrer are improved, the stirrer can be moved to the cleaning assembly for cleaning, the cleaning effect of the stirrer is better, the stirrer can be quickly taken out from the processing container and cleaned, it is convenient to carry out the next stirring operation, and the processing efficiency of the reagent is improved.

Description

Technical Field

[0001] The invention relates to the field of reagent processing, and in particular to a mass spectrometer detection reagent sampling processing device. Background Art

[0002] A mass spectrometer, also known as a mass spectrometer, is an instrument used to separate and detect different isotopes. It is based on the principle that charged particles can be deflected in an electromagnetic field, and separates and detects the composition of substances according to the mass differences of atoms, molecules or molecular fragments of substances. The core components of a mass spectrometer include an ion source, a mass analyzer and an ion detector. The ion source is responsible for ionizing the sample molecules under high vacuum conditions, and the mass analyzer separates the ions of different masses that enter it at the same time according to the mass-to-charge ratio. Finally, the ion detector collects and amplifies the ion signals, and draws a mass spectrum after computer processing. Mass spectrometers are widely used in many fields, such as: Chemistry and Earth Sciences: used for qualitative and quantitative analysis of heavy organic components in geological samples, and can also be combined with preparative chromatography for enrichment and preparation of biomarker compounds; Biomedicine: used for analysis of biomacromolecules such as proteomics and metabolomics; Food safety: used to detect harmful substances and additives in food; Environmental monitoring: used to monitor pollutants in air, water and soil; Materials science: used to analyze the composition and structure of materials.

[0003] Before the mass spectrometer is injected, the sample needs to be processed and made into a reagent. First, because the liquid chromatography part of the mass spectrometer is used to analyze liquid samples, the mobile phase flows out of the solvent bottle through the high-performance liquid chromatography pump and the injection valve, and then enters the chromatographic column. This is a very long and delicate system, so the sample entering the chromatography system must be liquid, and more importantly, free of particles. If the sample is not liquid, such as tissue samples and whole blood samples, it needs to be processed and converted into liquid. Secondly, the mass spectrometer part of the mass spectrometer converts liquid into gaseous ions and detects them under high vacuum conditions. Taking the two most commonly used ion sources, electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI), as examples, In order to ensure good ionization efficiency, the liquid sample entering the column must not contain non-volatile acids, bases or salts. On the other hand, based on the characteristics of the samples we want to analyze, one is that the sample is too "dirty". The "dirty" here means that the sample contains many substances that are not related to the target, such as proteins, cells, salts, etc., which cannot be directly fed into the mass spectrometer for analysis. For example, protein will precipitate at the column head without pretreatment, causing the column efficiency to decrease rapidly. At the same time, "dirty" also refers to the presence of substances in the sample that cause matrix effects. During the mass spectrometry ionization process, the matrix components will interfere with the ionization of the target (ion enhancement or ion suppression), causing the detection signal to increase or decrease, resulting in deviations in the detection results.

[0004] There are five main methods commonly used by existing mass spectrometers for biological samples: 1. Dilution method; 2. Protein precipitation method; 3. Liquid-liquid extraction method; 4. Solid phase extraction method; 5. Immunoaffinity extraction method, in which a large number of steps require the use of a magnetic stirrer for mixing the sample with the treating agent or the sample with the extraction solvent.

[0005] A magnetic stirrer is a commonly used laboratory equipment that drives the stirring bar in the container to rotate through a rotating magnetic field, thereby mixing the liquid sample. The working principle of the magnetic stirrer is to use a micromotor to drive a high-temperature resistant strong magnet to rotate, generate a rotating magnetic field, and then drive the stirring bar in the container to rotate, so as to achieve the purpose of stirring the liquid in the container.

[0006] Chinese patent CN109541093B discloses a nanoliter mass spectrometry sample pretreatment and sample injection combined device and method, comprising a bottom plate, a sample stage is installed on the bottom plate, a sample spotting slot is installed on the sample stage, a sliding component is provided in the X-axis and Y-axis directions of the sample spotting slot, and the sample spotting slot can move along the sliding component; a sample carrier is laid on the sample spotting slot, and the sample spotting slot is connected to the X-axis driving mechanism and the Y-axis driving mechanism respectively; a Z-axis driving mechanism is also installed on the bottom plate, and the Z-axis driving mechanism is detachably connected to the bottom plate; the output shaft of the Z-axis driving mechanism is connected to the ejector pin and the micro-injection syringe respectively; a mass spectrometer interface is also installed on the sample stage, which is used to connect the mass spectrometer and make the sample spotting slot and the mass spectrometer arranged relative to each other, so as to realize mass spectrometry analysis of the sample array after the sample spotting;

[0007] Chinese patent CN114247361B discloses a heating magnetic stirrer, comprising a shell, a base plate, a magnetic stirring device and a heating device; the base plate is connected to the bottom of the shell to form an installation cavity inside the shell; one end of the base plate has an air inlet channel; a heat dissipation groove is arranged on the upper surface of the top of the shell, a heat dissipation seat is arranged in the middle of the heat dissipation groove, the heat dissipation seat is provided with a first heat dissipation hole along the vertical direction, the heat dissipation groove has a plurality of radially distributed radial flow channels, the heat dissipation groove is provided with a first heat insulation plate and a heat insulation steel plate; a first heat insulation disk is arranged between the shell and the heating device, the magnetic stirring device includes a drive motor, a fan blade and a magnet; the magnet and the fan blade are an integral structure; the motor is connected to the fan blade drive; the heating device includes a second heat insulation disk and a heating disk connected to the upper end of the second heat insulation disk, which is easy to use, has good heat dissipation performance, and effectively insulates.

[0008] The above patents and prior art also have the following defects:

[0009] The magnetic stirrer in the prior art needs to take out the stirring bar in the reagent after stirring the sample reagent. However, the stirring bar is mostly elliptical or cylindrical, and the clamping force on the stirring bar is low. The stability of clamping the stirring bar is poor, and the stirring bar is easy to slide and fall. Taking out the stirring bar is time-consuming and laborious. After taking out the stirring bar, the stirring bar and the clamping tool need to be cleaned, and the cleaning efficiency is low.

[0010] Therefore, the present application provides a mass spectrometer detection reagent sample injection processing device to meet the needs. Summary of the invention

[0011] The purpose of the present application is to provide a mass spectrometer detection reagent sampling processing device, which can remove the stirrer by adsorption, improve the efficiency and stability of removing the stirrer, and can move the stirrer to a cleaning component for cleaning, which has a better cleaning effect on the stirrer, so that the stirrer can be quickly removed from the processing container and cleaned, which is convenient for the next stirring operation and improves the reagent processing efficiency.

[0012] To achieve the above-mentioned purpose, the present application provides the following technical solutions: a mass spectrometer detection reagent injection processing device, comprising a processing container, a stirring assembly is arranged below the processing container, the stirring assembly comprises a stirring rod and two stirring magnets, the two stirring magnets are located below the processing container, the stirring rod is located in the processing container, and the stirring magnet can rotate;

[0013] A retrieving assembly is provided on the top of the processing container, and a cleaning assembly is also provided on one side of the processing container. The retrieving assembly can move the stirring element in the processing container to the cleaning assembly, and the cleaning assembly can spray and clean the stirring element inside.

[0014] The retrieval component includes two outer attraction magnets and an inner attraction magnet. The outer attraction magnet, the inner attraction magnet, the stirring magnet and the stirring rod are all made of magnetic materials. The retrieval component also includes a driving unit, which can drive the inner attraction magnet and the outer attraction magnet to move vertically, and the movement direction of the inner attraction magnet is opposite to that of the outer attraction magnet.

[0015] Preferably, a lifting assembly is also provided on one side of the processing container, and the retracting assembly is arranged on the lifting assembly. The lifting assembly can drive the retracting assembly to move vertically. The lifting assembly includes a pushing block. When the lifting assembly drives the retracting assembly to descend into the processing container, the pushing block moves to push the stirring magnet to descend.

[0016] Preferably, the top magnetic poles of the two stirring magnets are in opposite directions, the bottom magnetic poles of the two external attraction magnets are in opposite directions, the magnetic poles at both ends of the stirring bar in the horizontal direction are in opposite directions, the magnetic poles at both ends of the internal attraction magnet in the horizontal direction are in opposite directions, and attraction grooves are provided at the bottom of the external attraction magnet and the internal attraction magnet.

[0017] Preferably, the driving unit includes a driving motor, a driving gear, an outer driving rack and an inner driving rack, the driving gear is fixedly mounted on the output end of the driving motor, the outer driving rack and the inner driving rack are both meshed with the driving gear, and the outer driving rack and the inner driving rack are located on both sides of the driving gear, and the outer driving rack can drive the outer attraction magnet to move when it moves, and the inner driving rack can drive the inner attraction magnet to move when it moves.

[0018] Preferably, the stirring assembly also includes a stirring unit and a moving unit, the stirring unit includes a stirring motor, a belt member, a stirring shaft and a fixed block, the two stirring magnets are fixedly mounted on the fixed block, the belt member includes a driving pulley, a passive pulley and a connecting belt, the driving pulley is fixedly mounted on the output end of the stirring motor, the passive pulley is fixedly mounted on the stirring shaft, the connecting belt is connected to the driving pulley and the passive pulley, a rectangular hole is opened on the fixed block, the cross-section of the stirring shaft is rectangular, and the stirring shaft passes through the rectangular hole and slides with the rectangular hole.

[0019] Preferably, the stirring assembly also includes a stirring base, the processing container is placed on the stirring base, the stirring motor is fixedly installed in the stirring base, the moving unit includes a limit rod, a moving plate, a return spring and a moving block, the fixed block is rotatably connected to the moving plate, the limit rod is fixedly installed on the stirring base, the limit rod passes through the moving plate and slides with the moving plate, one end of the return spring is fixedly installed on the bottom of the stirring base, the other end of the return spring is fixedly installed on the moving plate, the moving block is fixedly installed on the moving plate, and the moving block is located below the pushing block.

[0020] Preferably, the lifting assembly also includes a lifting motor, a lifting shell, a lifting screw, a lifting block and a lifting rod. The lifting shell is fixedly mounted on the stirring base, the lifting motor is fixedly mounted on the lifting shell, the lifting screw is rotatably connected in the lifting shell, and one end of the lifting screw is fixedly mounted on the output end of the lifting motor, the lifting block is sleeved on the lifting screw and threadedly connected to the lifting screw, the lifting rod is fixedly mounted on the lifting block, and when the lifting rod moves, it can drive the retrieval assembly to move.

[0021] Preferably, the retraction assembly also includes a fixed shell, a fixed plate, two external fixed rods, an internal fixed rod and a rotating unit, the driving motor is fixedly mounted on the fixed shell, the driving gear is rotatably connected in the fixed shell, the two external fixed rods are respectively fixedly mounted on the corresponding external attraction magnets, the internal fixed rod is fixedly mounted on the internal attraction magnet, the fixed plate is fixedly mounted on the two external fixed rods, the external drive rack is fixedly mounted on the fixed plate, the internal drive rack is fixedly mounted on the internal fixed rod, and the internal fixed rod passes through the fixed plate and slidably cooperates with the fixed plate.

[0022] Preferably, the rotating unit includes a rotating motor, a rotating rod and a connecting rod, the rotating motor is fixedly mounted on the lifting rod, the rotating rod is fixedly mounted on the output end of the rotating motor, the connecting rod is fixedly mounted on the end of the rotating rod, and the fixed shell is fixedly mounted on the connecting rod.

[0023] Preferably, a pushing assembly is provided on the fixed shell, and the pushing assembly includes an electric push rod and a pushing plate. The electric push rod is fixedly mounted on the fixed shell, and the pushing plate is fixedly mounted on the output end of the electric push rod. A pushing groove is provided at the bottom of the pushing plate.

[0024] Preferably, the cleaning assembly includes a cleaning shell, a plurality of top spray heads, a plurality of bottom spray heads and a plurality of side wall spray heads, the cleaning shell is fixedly mounted on the stirring base, a plurality of top spray heads are fixedly mounted on the inner side wall of the cleaning shell near the top, a plurality of bottom spray heads are fixedly mounted on the inner bottom of the cleaning shell, and a plurality of side wall spray heads are fixedly mounted on the inner side wall of the cleaning shell near the bottom.

[0025] In summary, the technical effects and advantages of the present invention are as follows:

[0026] 1. In the present invention, the retrieval component can be moved into the processing container to attract the stirrer, and drive the stirrer to move out of the processing container and into the cleaning component. There is no need to manually move the stirrer out of the processing container, which reduces the difficulty of clamping and taking out the stirrer from the processing container, improves the operating efficiency, takes out the stirrer by adsorption, improves the efficiency and stability of taking out the stirrer, can move the stirrer into the cleaning component for cleaning, and is more convenient to clean. When the stirrer is cleaned in the cleaning component, the inner attraction magnet and the outer attraction magnet are moved alternately, and the two ends and the middle position of the stirrer are alternately exposed for cleaning, which prevents the stirrer from being blocked and unable to be fully sprayed and cleaned, and has a better cleaning effect on the stirrer, so that the stirrer can be quickly taken out of the processing container and cleaned, which is convenient for the next stirring operation and improves the processing efficiency of the reagent;

[0027] 2. In the present invention, the two ends of the stirring bar have opposite magnetic poles, and the tops of the two stirring magnets have opposite magnetic poles, so that the stirring bar can be attracted by the stirring magnets. When the two stirring magnets rotate, the corresponding stirring magnet attracts the corresponding end of the stirring bar, and the other stirring magnet generates a repulsive force on the end, so that the movement of the stirring bar driven by the stirring magnet is more stable;

[0028] 3. In the present invention, the lifting assembly drives the retracting assembly to move downward with the pushing block, and when the pushing block moves downward until it contacts the moving block and continues to move downward, the pushing block drives the moving block to move, the moving block drives the moving plate to move, the moving plate drives the fixed block to move, and the fixed block drives the two stirring magnets to move downward, so that the two stirring magnets move downward away from the stirring bar in the processing container, reducing the attraction to the stirring bar, so that the stirring bar can be attracted by the retracting assembly and moved out of the processing container. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For those skilled in the art, other drawings can be obtained based on these drawings without paying any creative work.

[0030] Figure 1 It is a schematic diagram of the structure of the processing container, the stirring assembly, the recovery assembly, the cleaning assembly and the lifting assembly in the present invention;

[0031] Figure 2 It is a schematic structural diagram of a stirring bar, a stirring magnet, a stirring unit and a moving unit in the present invention;

[0032] Figure 3 For the present invention Figure 2 A magnified view of part A;

[0033] Figure 4 It is a structural schematic diagram of the retracting assembly, the rotating motor, the rotating rod and the connecting rod in the present invention;

[0034] Figure 5 For the present invention Figure 4 A magnified view of part B;

[0035] Figure 6 It is a schematic diagram of the structure of the cleaning shell, the top spray head, the bottom spray head and the side wall spray head in the present invention;

[0036] Figure 7 It is a schematic diagram of the structure of the lifting shell, the lifting screw, the lifting block and the lifting rod in the present invention;

[0037] Figure 8It is a schematic diagram of the structure of the processing container, the lifting shell, the lifting block and the pushing block in the present invention;

[0038] Fig. 9 For the present invention Figure 8 Enlarged view of part C;

[0039] Fig.10 It is a schematic diagram of the structure of the processing container, the lifting block, the lifting rod and the rotating rod in the present invention.

[0040] In the figure: 1, processing container; 2, stirring assembly; 21, stirring bar; 22, stirring magnet; 23, stirring unit; 231, stirring motor; 232, belt member; 233, stirring shaft; 234, fixed block; 24, moving unit; 241, limit rod; 242, moving plate; 243, return spring; 244, moving block; 25, stirring base; 3, retracting assembly; 31, external attraction magnet; 32, internal attraction magnet; 33, driving unit; 331, driving motor; 332, driving gear; 333, external driving rack; 334 , inner drive rack; 34, fixed shell; 35, fixed plate; 36, outer fixed rod; 37, inner fixed rod; 38, rotating unit; 381, rotating motor; 382, ​​rotating rod; 383, connecting rod; 4, cleaning assembly; 41, cleaning shell; 42, top spray head; 43, bottom spray head; 44, side wall spray head; 5, lifting assembly; 51, pushing block; 52, lifting motor; 53, lifting shell; 54, lifting screw; 55, lifting block; 56, lifting rod; 6, pushing assembly; 61, electric push rod; 62, pushing plate. DETAILED DESCRIPTION

[0041] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0042] Example: Reference Figure 1-Figure 10 A mass spectrometer detection reagent sampling processing device shown includes a processing container 1. A stirring assembly 2 is arranged below the processing container 1. The stirring assembly 2 includes a stirring rod 21 and two stirring magnets 22. The two stirring magnets 22 are located below the processing container 1. The stirring rod 21 is located in the processing container 1. The stirring magnet 22 can rotate.

[0043] A retrieving assembly 3 is disposed on the top of the processing container 1, and a cleaning assembly 4 is also disposed on one side of the processing container 1. The retrieving assembly 3 can move the stirring element 21 in the processing container 1 to the cleaning assembly 4, and the cleaning assembly 4 can spray and clean the stirring element 21 inside.

[0044] The retrieval component 3 includes two outer attraction magnets 31 and an inner attraction magnet 32. The outer attraction magnet 31, the inner attraction magnet 32, the stirring magnet 22 and the stirring bar 21 are all made of magnetic materials. The retrieval component 3 also includes a driving unit 33. The driving unit 33 can drive the inner attraction magnet 32 ​​and the outer attraction magnet 31 to move vertically, and the movement direction of the inner attraction magnet 32 ​​is opposite to that of the outer attraction magnet 31.

[0045] The stirrer 21 is placed in the processing container 1, the reagent is placed in the processing container 1, and the processing agent is added to the processing container 1. The two stirring magnets 22 rotate and attract the stirrer 21 in the processing container 1 to rotate. The stirrer 21 stirs the reagent. When the stirring is completed and the stirrer 21 needs to be taken out, the retracting component 3 moves into the processing container 1, and the inner attraction magnet 32 ​​and the outer attraction magnet 31 attract the stirrer 21. The retracting component 3 moves the stirrer 21 into the cleaning component 4. The cleaning component 4 sprays and cleans the stirrer 21. In the process of spraying and cleaning the stirrer 21, the driving unit 33 drives the inner attraction magnet 32 ​​and the outer attraction magnet 31 to move vertically. And the moving directions are opposite. When the inner attraction magnet 32 ​​moves downward, the inner attraction magnet 32 ​​drives the stirrer 21 to move, and the outer attraction magnet 31 moves upward and separates from the stirrer 21, exposing the positions of the two ends of the stirrer 21, and the cleaning component 4 cleans the two ends of the stirrer 21. When the outer attraction magnet 31 moves downward, the outer attraction magnet 31 drives the stirrer 21 to move, and the inner attraction magnet 32 ​​moves upward and separates from the stirrer 21, exposing the middle position of the stirrer 21, and the cleaning component 4 cleans the middle position of the stirrer 21. The inner attraction magnet 32 ​​and the outer attraction magnet 31 move alternately, and the two ends and the middle position of the stirrer 21 are alternately exposed for cleaning.

[0046] The retrieval component 3 can be moved into the processing container 1 to attract the stirrer 21, and drive the stirrer 21 to move out of the processing container 1 and into the cleaning component 4. There is no need to manually move the stirrer 21 out of the processing container 1, which reduces the difficulty of clamping and removing the stirrer 21 from the processing container 1, improves the operating efficiency, and can move the stirrer 21 into the cleaning component 4 for cleaning, which makes it more convenient to clean the stirrer 21. When the stirrer 21 is cleaned in the cleaning component 4, the inner attraction magnet 32 ​​and the outer attraction magnet 31 move alternately, and the two ends and the middle position of the stirrer 21 are alternately exposed for cleaning, preventing the stirrer 21 from being blocked and unable to be fully sprayed and cleaned, and having a better cleaning effect on the stirrer 21, so that the stirrer 21 can be quickly taken out of the processing container 1 and cleaned, which is convenient for the next stirring operation and improves the processing efficiency of the reagent.

[0047] Further, refer to Figure 1-Figure 10A lifting assembly 5 is also provided on one side of the processing container 1. The retracting assembly 3 is provided on the lifting assembly 5. The lifting assembly 5 can drive the retracting assembly 3 to move vertically. The lifting assembly 5 includes a pushing block 51. When the lifting assembly 5 drives the retracting assembly 3 to descend into the processing container 1, the pushing block 51 moves to push the stirring magnet 22 to descend.

[0048] The lifting assembly 5 drives the retracting assembly 3 to move vertically. When the outer attraction magnet 31 and the inner attraction magnet 32 ​​move to a position close to the bottom of the processing container 1, the pushing block 51 moves to push the stirring magnet 22 downward, so that the stirring magnet 22 is away from the stirring bar 21 in the processing container 1, reducing the attraction of the stirring magnet 22 to the stirring bar 21, so that the stirring bar 21 can be attracted by the outer attraction magnet 31 and the inner attraction magnet 32 ​​and driven to rise.

[0049] Further, refer to Figure 1-Figure 10 The top magnetic poles of the two stirring magnets 22 are in opposite directions, the bottom magnetic poles of the two outer attraction magnets 31 are in opposite directions, the magnetic poles at both ends of the stirring bar 21 in the horizontal direction are in opposite directions, the magnetic poles at both ends of the inner attraction magnet 32 ​​in the horizontal direction are in opposite directions, and attraction grooves are provided at the bottom of the outer attraction magnets 31 and the inner attraction magnets 32.

[0050] The magnetic poles at both ends of the stirring bar 21 are opposite, and the magnetic poles at the tops of the two stirring magnets 22 are opposite, so that the stirring bar 21 can be attracted by the stirring magnets 22. When the two stirring magnets 22 rotate, the corresponding stirring magnet 22 attracts the corresponding end of the stirring bar 21, and the other stirring magnet 22 will generate a repulsive force on this end, so that the stirring magnet 22 rotates to drive the stirring bar 21 to rotate more stably. The magnetic poles at both ends of the inner attraction magnet 32 ​​are in opposite directions, which can match the magnetic poles at both ends of the stirring bar 21 and attract the stirring bar 21. The bottom magnetic poles of the two outer attraction magnets 31 are in opposite directions, which can also match the magnetic poles at both ends of the stirring bar 21, which has a better attraction effect on the stirring bar 21 and drives the stirring bar 21 to move more stably.

[0051] The inner stirring magnet 22 and the outer stirring magnet 22 are both wrapped with non-magnetic material, and only a gap is opened at the attraction groove, so that the attraction groove position of the inner stirring magnet 22 and the outer stirring magnet 22 has a stronger attraction to the stirring bar 21, and the stirring bar 21 is attracted into the attraction groove, which has a stronger attraction to the stirring bar 21, increases the stability of driving the stirring bar 21 to move, and prevents the stirring bar 21 from falling off.

[0052] Further, refer to Figure 1-Figure 10The driving unit 33 includes a driving motor 331, a driving gear 332, an outer driving rack 333 and an inner driving rack 334. The driving gear 332 is fixedly installed at the output end of the driving motor 331. The outer driving rack 333 and the inner driving rack 334 are both engaged with the driving gear 332, and the outer driving rack 333 and the inner driving rack 334 are located on both sides of the driving gear 332. When the outer driving rack 333 moves, it can drive the outer attraction magnet 31 to move, and when the inner driving rack 334 moves, it can drive the inner attraction magnet 32 ​​to move.

[0053] The driving motor 331 drives the driving gear 332 to rotate, and the driving gear 332 drives the outer driving rack 333 and the inner driving rack 334 to move. Since the outer driving rack 333 and the inner driving rack 334 are respectively engaged with the two sides of the driving gear 332, the moving directions of the outer driving rack 333 and the inner driving rack 334 are opposite. The outer driving rack 333 drives the outer attraction magnet 31 to move, and the inner driving rack 334 drives the inner attraction magnet 32 ​​to move.

[0054] Further, refer to Figure 1-Figure 10 The stirring assembly 2 also includes a stirring unit 23 and a moving unit 24. The stirring unit 23 includes a stirring motor 231, a belt member 232, a stirring shaft 233 and a fixed block 234. The two stirring magnets 22 are fixedly mounted on the fixed block 234. The belt member 232 includes a driving pulley, a passive pulley and a connecting belt. The driving pulley is fixedly mounted on the output end of the stirring motor 231, the passive pulley is fixedly mounted on the stirring shaft 233, the connecting belt is connected to the driving pulley and the passive pulley, a rectangular hole is opened on the fixed block 234, and the cross-section of the stirring shaft 233 is rectangular. The stirring shaft 233 passes through the rectangular hole and slides with the rectangular hole.

[0055] The stirring motor 231 drives the active pulley to rotate, the active pulley drives the connecting belt to rotate, the connecting belt causes the passive pulley to rotate, the passive pulley drives the stirring shaft 233 to rotate, the stirring shaft 233 drives the fixed block 234 to rotate, the fixed block 234 drives the two stirring magnets 22 to rotate, the two stirring magnets 22 drive the stirring bar 21 in the processing container 1 to rotate through magnetic attraction, and the stirring bar 21 stirs the reagent in the processing container 1.

[0056] Further, refer to Figure 1-Figure 10The stirring assembly 2 also includes a stirring base 25, the processing container 1 is placed on the stirring base 25, the stirring motor 231 is fixedly installed in the stirring base 25, the moving unit 24 includes a limiting rod 241, a moving plate 242, a reset spring 243 and a moving block 244, the fixed block 234 is rotatably connected to the moving plate 242, the limiting rod 241 is fixedly installed on the stirring base 25, the limiting rod 241 penetrates the moving plate 242 and slidably cooperates with the moving plate 242, one end of the reset spring 243 is fixedly installed on the bottom of the stirring base 25, the other end of the reset spring 243 is fixedly installed on the moving plate 242, the moving block 244 is fixedly installed on the moving plate 242, and the moving block 244 is located below the pushing block 51.

[0057] When the lifting component 5 drives the retracting component 3 to move downward, the pushing block 51 moves with it. When the pushing block 51 moves downward until it contacts the moving block 244 and continues to move downward, the pushing block 51 pushes the moving block 244 to move. The moving block 244 drives the moving plate 242 to move. The moving plate 242 drives the fixed block 234 to move. The fixed block 234 drives the two stirring magnets 22 to move downward, so that the two stirring magnets 22 move downward away from the stirring bar 21 in the processing container 1, reducing the attraction to the stirring bar 21, so that the stirring bar 21 can be attracted by the retracting component 3 and thus moved out of the processing container 1.

[0058] When the movable plate 242 moves downward, the reset spring 243 is compressed. When the lifting assembly 5 drives the retracting assembly 3 to move upward, the reset spring 243 pushes the movable plate 242 to move upward, and the movable plate 242 drives the fixed block 234 to move upward. The fixed block 234 drives the stirring magnet 22 to move upward, so that the stirring magnet 22 is against the top inner wall of the stirring base 25, and the fixed block 234 moves on the stirring shaft 233. The cross-section of the stirring shaft 233 is a rectangular setting that cooperates with the rectangular hole on the fixed block 234, so that the stirring shaft 233 can drive the fixed block 234 and the stirring magnet 22 to rotate.

[0059] Further, refer to Figure 1-Figure 10 The lifting assembly 5 also includes a lifting motor 52, a lifting shell 53, a lifting screw 54, a lifting block 55 and a lifting rod 56. The lifting shell 53 is fixedly mounted on the stirring base 25, the lifting motor 52 is fixedly mounted on the lifting shell 53, the lifting screw 54 is rotatably connected in the lifting shell 53, and one end of the lifting screw 54 is fixedly mounted on the output end of the lifting motor 52, the lifting block 55 is sleeved on the lifting screw 54 and is threadedly connected to the lifting screw 54, and the lifting rod 56 is fixedly mounted on the lifting block 55. When the lifting rod 56 moves, it can drive the retracting assembly 3 to move.

[0060] The lifting motor 52 drives the lifting screw 54 to rotate, the moving block 244 moves on the lifting screw 54, the moving block 244 drives the lifting rod 56 to move, and the lifting rod 56 drives the retracting assembly 3 to move vertically.

[0061] Further, refer to Figure 1-Figure 10 The retracting assembly 3 also includes a fixed shell 34, a fixed plate 35, two external fixed rods 36, an internal fixed rod 37 and a rotating unit 38. The driving motor 331 is fixedly mounted on the fixed shell 34, and the driving gear 332 is rotatably connected in the fixed shell 34. The two external fixed rods 36 are respectively fixedly mounted on the corresponding external attraction magnets 31, and the internal fixed rod 37 is fixedly mounted on the internal attraction magnet 32. The fixed plate 35 is fixedly mounted on the two external fixed rods 36, the external drive rack 333 is fixedly mounted on the fixed plate 35, and the internal drive rack 334 is fixedly mounted on the internal fixed rod 37. The internal fixed rod 37 passes through the fixed plate 35 and slidably cooperates with the fixed plate 35.

[0062] The driving motor 331 drives the driving gear 332 to move, the driving gear 332 drives the outer driving rack 333 and the inner driving rack 334 to move, the outer driving rack 333 drives the outer fixing rod 36 to move, the outer fixing rod 36 drives the outer attraction magnet 31 to move, the inner driving rack 334 drives the inner fixing rod 37 to move, and the inner fixing rod 37 drives the inner attraction magnet 32 ​​to move.

[0063] Further, refer to Figure 1-Figure 10 The rotating unit 38 includes a rotating motor 381, a rotating rod 382 and a connecting rod 383. The rotating motor 381 is fixedly mounted on the lifting rod 56, the rotating rod 382 is fixedly mounted on the output end of the rotating motor 381, the connecting rod 383 is fixedly mounted on the end of the rotating rod 382, ​​and the fixed shell 34 is fixedly mounted on the connecting rod 383.

[0064] The rotating motor 381 drives the rotating rod 382 to rotate, the rotating rod 382 drives the connecting rod 383 to rotate, the connecting rod 383 drives the fixed shell 34 to rotate, and the external attraction magnet 31 and the internal attraction magnet 32 ​​in the fixed shell 34 drive the stirring rod 21 to move, so that the stirring rod 21 can move between the processing container 1 and the cleaning component 4.

[0065] Further, refer to Figure 1-Figure 10 A pushing assembly 6 is provided on the fixed shell 34, and the pushing assembly 6 includes an electric push rod 61 and a pushing plate 62. The electric push rod 61 is fixedly installed on the fixed shell 34, and the pushing plate 62 is fixedly installed at the output end of the electric push rod 61. A pushing groove is opened at the bottom of the pushing plate 62.

[0066] When it is necessary to move the stirrer 21 into the processing container 1, the retracting component 3 drives the stirrer 21 to move to the bottom of the processing container 1, and the electric push rod 61 drives the push plate 62 to move downward. The push plate 62 pushes the stirrer 21 attracted by the outer attraction magnet 31 and the inner attraction magnet 32 ​​downward, so that the stirrer 21 is separated from the attraction of the outer attraction magnet 31 and the inner attraction magnet 32 ​​and falls into the processing container 1.

[0067] Further, refer to Figure 1-Figure 10 The cleaning assembly 4 includes a cleaning shell 41, a plurality of top spray heads 42, a plurality of bottom spray heads 43 and a plurality of side wall spray heads 44. The cleaning shell 41 is fixedly mounted on the stirring base 25, a plurality of top spray heads 42 are fixedly mounted on the inner side wall of the cleaning shell 41 near the top, a plurality of bottom spray heads 43 are fixedly mounted on the inner bottom of the cleaning shell 41, and a plurality of side wall spray heads 44 are fixedly mounted on the inner side wall of the cleaning shell 41 near the bottom.

[0068] The lifting assembly 5 drives the retracting assembly 3 to descend into the processing container 1, the outer attraction magnet 31 and the inner attraction magnet 32 ​​adsorb the stirring bar 21 in the processing container 1, the lifting assembly 5 drives the retracting assembly 3 to rise, the retracting assembly 3 drives the stirring bar 21 to rise to the outside of the processing container 1, the rotating unit 38 drives the stirring bar 21 to rotate above the cleaning shell 41, the lifting assembly 5 drives the retracting assembly 3 to descend, the stirring bar 21 on the retracting assembly 3 descends and moves into the cleaning shell 41, when the fixed shell 34 and the connecting rod 383 move downward in the cleaning shell 41, the top spray head 42 sprays the cleaning liquid to clean the fixed shell 34 and the connecting rod 383, so that the stirring bar 21 extending into the processing container The fixed shell 34 and the connecting rod 383 of the stirrer 1 are kept clean. After the stirrer 21 enters the cleaning shell 41 near the bottom, the bottom spray head 43 and the side wall spray head 44 are located at the bottom and upper side of the stirrer 21 to spray and clean the stirrer 21, which has a better cleaning effect on the stirrer 21. After cleaning the stirrer 21, the lifting component 5 drives the retracting component 3 and the stirrer 21 to rise to the outside of the cleaning shell 41, and the rotating unit 38 drives the stirrer 21 to rotate above the processing container 1. The lifting component 5 drives the retracting component 3 and the stirrer 21 to descend into the processing container 1, and the pushing component 6 pushes the stirrer 21 into the processing container 1 for the next stirring.

[0069] A plurality of top spray heads 42, a plurality of bottom spray heads 43 and a plurality of side wall spray heads 44 are all connected to the water pump. The pressure of the top spray heads 42, the plurality of bottom spray heads 43 and the plurality of side wall spray heads 44 is relatively low, and the stirring bar 21 will not be flushed off the outer attraction magnet 31 and the inner attraction magnet 32. A dryer is provided in the cleaning shell 41 to dry the stirring bar 21, which is not easy to breed bacteria and enables the stirring bar 21 to quickly carry out the next operation.

[0070] When the stirrer 21 stirs the reagent in the processing container 1 , the retrieving assembly 3 is located in the cleaning shell 41 , which will not hinder the addition of the processing agent into the processing container 1 , and is more convenient.

[0071] A plurality of side wall spray heads 44 are arranged to be inclined downward.

[0072] A side wall of the cleaning shell 41 close to the bottom is fixedly connected to a drain pipe, which can discharge the cleaning liquid in the cleaning shell 41.

[0073] Finally, it should be noted that the above is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, it is still possible for those skilled in the art to modify the technical solutions described in the aforementioned embodiments, or to make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A mass spectrometer detection reagent sample processing device, comprising a processing container (1) characterized in that: A stirring assembly (2) is arranged below the processing container (1), the stirring assembly (2) comprising a stirring bar (21) and two stirring magnets (22), the two stirring magnets (22) are located below the processing container (1), the stirring bar (21) is located inside the processing container (1), and the stirring magnets (22) are rotatable; A retrieving component (3) is disposed on the top of the processing container (1), and a cleaning component (4) is also disposed on one side of the processing container (1). The retrieving component (3) is capable of moving the stirring element (21) in the processing container (1) into the cleaning component (4), and the cleaning component (4) is capable of spraying and cleaning the stirring element (21) inside. The retracting assembly (3) comprises two outer attracting magnets (31) and an inner attracting magnet (32), the outer attracting magnet (31), the inner attracting magnet (32), the stirring magnet (22) and the stirring bar (21) are all made of magnetic materials, and the retracting assembly (3) further comprises a driving unit (33), the driving unit (33) can drive the inner attracting magnet (32) and the outer attracting magnet (31) to move vertically, and the movement direction of the inner attracting magnet (32) is opposite to that of the outer attracting magnet (31); The driving unit (33) comprises a driving motor (331), a driving gear (332), an outer driving rack (333) and an inner driving rack (334); the driving gear (332) is fixedly mounted on the output end of the driving motor (331); the outer driving rack (333) and the inner driving rack (334) are both meshed with the driving gear (332); the outer driving rack (333) and the inner driving rack (334) are located on both sides of the driving gear (332); when the outer driving rack (333) moves, it can drive the outer attraction magnet (31) to move; when the inner driving rack (334) moves, it can drive the inner attraction magnet (32) to move.

2. A mass spectrometer detection reagent sample injection processing device according to claim 1, characterized in that: A lifting assembly (5) is also provided on one side of the processing container (1). The retracting assembly (3) is provided on the lifting assembly (5). The lifting assembly (5) can drive the retracting assembly (3) to move vertically. The lifting assembly (5) includes a pushing block (51). When the lifting assembly (5) drives the retracting assembly (3) to descend into the processing container (1), the pushing block (51) moves to push the stirring magnet (22) to descend.

3. A mass spectrometer detection reagent sample injection processing device according to claim 1, characterized in that: The top magnetic poles of the two stirring magnets (22) are in opposite directions, the bottom magnetic poles of the two outer attraction magnets (31) are in opposite directions, the magnetic poles of both ends of the stirring bar (21) in the horizontal direction are in opposite directions, the magnetic poles of both ends of the inner attraction magnet (32) in the horizontal direction are in opposite directions, and attraction grooves are provided at the bottoms of the outer attraction magnets (31) and the inner attraction magnets (32).

4. A mass spectrometer detection reagent sample injection processing device according to claim 2, characterized in that: The stirring assembly (2) further comprises a stirring unit (23) and a moving unit (24), wherein the stirring unit (23) comprises a stirring motor (231), a belt member (232), a stirring shaft (233) and a fixed block (234), wherein the two stirring magnets (22) are fixedly mounted on the fixed block (234), wherein the belt member (232) comprises a driving pulley, a driven pulley and a connecting belt, wherein the driving pulley is fixedly mounted on the output end of the stirring motor (231), the driven pulley is fixedly mounted on the stirring shaft (233), and the connecting belt is connected to the driving pulley and the driven pulley, wherein a rectangular hole is formed on the fixed block (234), wherein the cross section of the stirring shaft (233) is rectangular, and wherein the stirring shaft (233) passes through the rectangular hole and is slidably matched with the rectangular hole.

5. A mass spectrometer detection reagent sample injection processing device according to claim 4, characterized in that: The stirring assembly (2) further comprises a stirring base (25), the processing container (1) is placed on the stirring base (25), the stirring motor (231) is fixedly mounted in the stirring base (25), the moving unit (24) comprises a limiting rod (241), a moving plate (242), a return spring (243) and a moving block (244), the fixed block (234) is rotatably connected to the moving plate (242), the limiting rod (241) is fixedly mounted on the stirring base (25), the limiting rod (241) passes through the moving plate (242) and slidably cooperates with the moving plate (242), one end of the return spring (243) is fixedly mounted on the bottom of the stirring base (25), and the other end of the return spring (243) is fixedly mounted on the moving plate (242), the moving block (244) is fixedly mounted on the moving plate (242), and the moving block (244) is located below the pushing block (51).

6. A mass spectrometer detection reagent sample injection processing device according to claim 5, characterized in that: The lifting assembly (5) further comprises a lifting motor (52), a lifting shell (53), a lifting screw (54), a lifting block (55) and a lifting rod (56); the lifting shell (53) is fixedly mounted on the stirring base (25); the lifting motor (52) is fixedly mounted on the lifting shell (53); the lifting screw (54) is rotatably connected in the lifting shell (53); one end of the lifting screw (54) is fixedly mounted on the output end of the lifting motor (52); the lifting block (55) is sleeved on the lifting screw (54) and is threadedly connected to the lifting screw (54); the lifting rod (56) is fixedly mounted on the lifting block (55); and when the lifting rod (56) moves, it can drive the retracting assembly (3) to move.

7. A mass spectrometer detection reagent sample injection processing device according to claim 6, characterized in that: The retracting assembly (3) further comprises a fixed shell (34), a fixed plate (35), two outer fixed rods (36), an inner fixed rod (37) and a rotating unit (38); the driving motor (331) is fixedly mounted on the fixed shell (34); the driving gear (332) is rotatably connected in the fixed shell (34); the two outer fixed rods (36) are respectively fixedly mounted on the corresponding outer attracting magnets (31); the inner fixed rod (37) is fixedly mounted on the inner attracting magnet (32); the fixed plate (35) is fixedly mounted on the two outer fixed rods (36); the outer driving rack (333) is fixedly mounted on the fixed plate (35); the inner driving rack (334) is fixedly mounted on the inner fixed rod (37); the inner fixed rod (37) passes through the fixed plate (35) and is slidably matched with the fixed plate (35); The fixed housing (34) is provided with a pushing assembly (6), the pushing assembly (6) comprising an electric push rod (61) and a pushing plate (62), the electric push rod (61) being fixedly mounted on the fixed housing (34), the pushing plate (62) being fixedly mounted on the output end of the electric push rod (61), and a pushing groove being provided at the bottom of the pushing plate (62).

8. A mass spectrometer detection reagent sample injection processing device according to claim 7, characterized in that: The rotating unit (38) comprises a rotating motor (381), a rotating rod (382) and a connecting rod (383); the rotating motor (381) is fixedly mounted on the lifting rod (56); the rotating rod (382) is fixedly mounted on the output end of the rotating motor (381); the connecting rod (383) is fixedly mounted on the end of the rotating rod (382); and the fixed housing (34) is fixedly mounted on the connecting rod (383).

9. A mass spectrometer detection reagent sample injection processing device according to claim 5, characterized in that: The cleaning assembly (4) comprises a cleaning shell (41), a plurality of top spray heads (42), a plurality of bottom spray heads (43) and a plurality of side wall spray heads (44); the cleaning shell (41) is fixedly mounted on the stirring base (25); the plurality of top spray heads (42) are fixedly mounted on the inner side wall of the cleaning shell (41) near the top; the plurality of bottom spray heads (43) are fixedly mounted on the inner bottom of the cleaning shell (41); and the plurality of side wall spray heads (44) are fixedly mounted on the inner side wall of the cleaning shell (41) near the bottom.

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