Color-stable whitening composition and skin whitening product

Abstract

The embodiment of the invention discloses a color-stable whitening composition and a skin whitening product. The color-stable whitening composition comprises arbutin, tranexamic acid and a color stabilizer, and the color stabilizer comprises ascorbyl glucoside and ergothioneine. The whitening composition is stable in color and not prone to discoloring, and meanwhile the good skin whitening and anti-oxidation effects can be achieved.

Description

Technical Field

[0001] Embodiments of the present disclosure relate to the field of biotechnology, and more particularly to color-stable whitening compositions and skin whitening products. Background Art

[0002] Due to the external environment, genetics, endocrine disorders, bad living habits, etc., excessive pigment production leads to dull skin, spots and other problems, which has become one of the main skin problems that people are increasingly concerned about. Among them, melanin is one of the main determinants of skin color, and its content and distribution have a close impact on the degree of skin darkening. Specifically, the human body is mainly composed of two types of melanin and pheomelanin. The amount and ratio of eumelanin and pheomelanin deposited in the epidermis determine a person's skin color. In practice, the lower the ratio, the lighter the skin color. At present, common skin care products often achieve the purpose of skin whitening from the perspectives of ultraviolet protection, inhibition of melanin production and transport, etc.

[0003] However, common skin care products are often composed of at least one component, and different components may cause combined discoloration during the compounding process.

[0004] The above information disclosed in this Background section is only for enhancement of understanding of the background of the inventive concept and therefore it may contain information that does not form the prior art that is already known to a person of ordinary skill in the art. Summary of the invention

[0005] The content of this disclosure is used to introduce concepts in a brief form, which will be described in detail in the detailed implementation section below. The content of this disclosure is not intended to identify the key features or essential features of the technical solution claimed for protection, nor is it intended to limit the scope of the technical solution claimed for protection.

[0006] Some embodiments of the present disclosure provide color-stable whitening compositions and skin whitening products to solve one or more of the technical problems mentioned in the above background technology section.

[0007] In a first aspect, some embodiments of the present disclosure provide a color-stable whitening composition, the composition comprising: arbutin; tranexamic acid; a color stabilizer, wherein the color stabilizer comprises: ascorbyl glucoside and ergothioneine.

[0008] Optionally, the mass ratio of the arbutin to the tranexamic acid is 1:0.5-5.

[0009] Optionally, the mass ratio of the arbutin to the color stabilizer is 1:0.05-1.

[0010] Optionally, the mass ratio of the ascorbyl glucoside to ergothioneine is 10 to 100:1.

[0011] Optionally, the whitening composition further comprises: one or more of a whitening agent, a pH regulator and a skin feel regulator.

[0012] Optionally, the skin feel regulator includes one or more of a moisturizer, an emulsifier, a thickener, and a surfactant.

[0013] Optionally, the whitening composition also includes other whitening ingredients besides the whitening agent, wherein the whitening ingredients may include: phenylethylresorcinol, nicotinamide, acetyl glucosamine, tetrahydrocurcumin, glabridin, licorice root extract, ellagic acid, punicalagin, phloretin, methyl chalcone hesperidin, glucosyl hesperidin, hesperidin, naringin, resveratrol, ascorbyl tetraisostearate, kojic acid, glutathione, raspberry glucoside, 4-butylresorcinol, succinic acid, salicylic acid, acetyltyrosine, diglucosyl gallic acid, acetyl glucosamine , heparin sodium, AHA, BHA, azelaic acid, MEA, azelaic acid, potassium 4-methoxysalicylate, polydatin, sulforaphane, ferulic acid, adenosine, algae extract, hydrolyzed conchiolin, EGCG, lactobionic acid, lactic acid, tartaric acid, γ-gluconolactone, nonapeptide-1, daisy flower extract, aloesin, dihydromyricetin, undecylenoyl phenylalanine, sea fennel callus culture fluid, papain, bromelain, sutyllanase, octadecenedioic acid, hexyldecanol, idebenone, astaxanthin.

[0014] Optionally, the pH adjuster may include: one or more of hydroxyethylpiperazineethane sulfonic acid, citric acid, sodium citrate, disodium hydrogen phosphate, and sodium dihydrogen phosphate.

[0015] Optionally, the thickener includes: a natural thickener, a semi-synthetic thickener and a synthetic thickener.

[0016] Optionally, the natural thickener includes one or more of taro gum, xanthan gum, agarose, cellulose gum, carrageenan, pullulan, sphingosine gum, sodium alginate, carob gum, and guar gum.

[0017] Optionally, the semi-synthetic thickener includes one or more of hydroxyethyl cellulose, hydroxypropyl cellulose, and hydroxypropyl methyl cellulose.

[0018] Optionally, the synthetic thickener may include: carbomer, sodium polyacrylate, acrylates / C10-C30 alkyl acrylate copolymer, acrylate / C10-C30 alkyl acrylate cross-linked copolymer, acrylate copolymer, polyacrylate-1 cross-linked polymer, acrylic acid / acryloyl nitrogen copolymer, acrylate / stearyl alcohol polyether (20) methacrylate copolymer, acrylate / behenyl alcohol polyether (25) methacrylate copolymer, acrylate / stearyl alcohol polyether-20 itaconate copolymer, acrylate / amino acrylate copolymer, acrylate / vinyl isodecanol cross-linked polymer, ammonium acryloyldimethyltaurate / behenyl alcohol polyether-25 methacrylate cross-linked polymer, sodium acryloyldimethyltaurate / VP cross-linked polymer, ammonium acryloyldimethyltaurate / VP copolymer.

[0019] In a second aspect, some embodiments of the present disclosure provide a skin whitening product, which includes the color-stable whitening composition as described above in the first aspect.

[0020] Optionally, the above-mentioned skin whitening product includes: one or more of: water solution, emulsion, cream, ointment, gel, and facial mask.

[0021] In a third aspect, some embodiments of the present disclosure provide a use of ascorbyl glucoside and ergothioneine as color stabilizers in a whitening composition, wherein the whitening composition comprises arbutin and tranexamic acid.

[0022] The above-mentioned various embodiments of the present disclosure have the following beneficial effects: through the color-stable whitening composition of some embodiments of the present disclosure, the problem of combined discoloration of different components during the compounding process is solved. In practice, arbutin, as a whitening ingredient, is mainly classified into three types: α-arbutin, β-arbutin, and D-arbutin. As a naturally occurring glucoside hydroquinone derivative, it can achieve the purpose of whitening by inhibiting the activity of tyrosinase in the process of melanin synthesis. Tranexamic acid, as a synthetic lysine derivative, can inhibit the activation of plasminogen by blocking the lysine binding site on the plasminogen molecule, can also inhibit ultraviolet-induced fibrinase activity, and can also indirectly affect the production of melanin by reducing the production of prostaglandins (PGE2). Although the single water solubility of tranexamic acid has good stability, it will discolor or brown when compounded with common cosmetic ingredients. After research, it was found that tranexamic acid and sugars, including polyhydroxy sugar derivatives, will undergo browning reactions. It is found in practice that the actual active content of arbutin and tranexamic acid does not change much when used alone, but discoloration will occur, thus affecting the user experience. Therefore, the present disclosure attempts to add antioxidant ingredients, such as high-content sodium pyrosulfite, on the basis of arbutin and tranexamic acid. However, further research has found that sodium pyrosulfite will produce sulfur dioxide, that is, produce a strong irritating odor. At the same time, sodium pyrosulfite has high conductivity and very strong ionicity, so it is necessary to compound a thickener with strong anti-ionicity, and this type of thickener has poor skin feel and has greater restrictions on the formula. Based on this, the present disclosure attempts to add ascorbyl glucoside and ergothioneine as color stabilizers on the basis of arbutin and tranexamic acid. Experiments have found that the tranexamic acid and arbutin included in the color-stable whitening composition of the present disclosure can complement each other in the pathway of melanin formation metabolism, achieving a whitening effect that inhibits melanin production. At the same time, ascorbyl glucoside and ergothioneine are used as color stabilizers to ensure the color stability of the whitening composition. In addition, ascorbyl glucoside releases vitamin C through glycosidase hydrolysis in skin cells, and dark oxidative melanin can be directly reduced to light-colored reducing pigment, thereby further achieving whitening effect. Meanwhile, ergothioneine can also further promote the antioxidant effect of whitening composition. In summary, the above-mentioned whitening composition is color-stable, not easy to change color, and can also play a good skin whitening and antioxidant effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] The above and other features, advantages and aspects of the embodiments of the present disclosure will become more apparent with reference to the following detailed description in conjunction with the accompanying drawings. Throughout the accompanying drawings, the same or similar reference numerals represent the same or similar elements. It should be understood that the drawings are schematic and the elements are not necessarily drawn to scale.

[0024] Figure 1This is a color stability comparison chart of Comparative Example 1, Comparative Example 2, Comparative Example 3, Comparative Example 4, Comparative Example 5, Comparative Example 6, Comparative Example 7, Comparative Example 8, and Comparative Example 9 at 50°C;

[0025] Figure 2 This is a schematic diagram of the appearance of the test sample corresponding to Example 1;

[0026] Figure 3 This is a schematic diagram of the appearance of the test sample corresponding to Example 2;

[0027] Figure 4 This is a schematic diagram of the appearance of the test sample corresponding to Comparative Example 9;

[0028] Figure 5 is a color stability comparison chart of Example 1, Example 2, Example 3, Example 4, Example 5, Example 6, Example 7, Example 8, and Example 9 at 50° C.;

[0029] Figure 6 is a schematic diagram of the appearance of the test sample corresponding to Example 1;

[0030] Figure 7 is a schematic diagram of the appearance of the test sample corresponding to Example 3;

[0031] Figure 8 is a color stability comparison chart of Example 10, Example 11, Example 12, Example 13, Example 14, and Example 15 at 50° C.;

[0032] Fig. 9 The skin imaging diagrams under different spectra are the whitening test results of Application Example 1. DETAILED DESCRIPTION

[0033] Embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. Although certain embodiments of the present disclosure are shown in the accompanying drawings, it should be understood that the present disclosure can be implemented in various forms and should not be construed as being limited to the embodiments set forth herein. On the contrary, these embodiments are provided to provide a more thorough and complete understanding of the present disclosure. It should be understood that the drawings and embodiments of the present disclosure are only for exemplary purposes and are not intended to limit the scope of protection of the present disclosure.

[0034] It should also be noted that, for ease of description, only the parts related to the invention are shown in the drawings. In the absence of conflict, the embodiments and features in the embodiments of the present disclosure can be combined with each other.

[0035] It should be noted that the modifications of "one" and "plurality" mentioned in the present disclosure are illustrative rather than restrictive, and those skilled in the art should understand that unless otherwise clearly indicated in the context, it should be understood as "one or more".

[0036] It should be noted that the term “about” mentioned in the present disclosure, when used to define a numerical value, means ±5% of the specified numerical value.

[0037] It should be noted that the term "%" mentioned in the present disclosure means mass % unless otherwise specified.

[0038] It should be noted that the "normal temperature" mentioned in the present disclosure refers to the ambient temperature, that is, no special heating or cooling treatment has been performed.

[0039] Explanation of terms

[0040] The term "tranexamic acid", also known as tranexamic acid, tranexamic acid, trans-4-(aminomethyl)cyclohexanecarboxylic acid, and p-aminomethylcyclohexanecarboxylic acid, is a synthetic amino acid.

[0041] The term "ascorbyl glucoside" is a natural vitamin C that is white powder or crystal, easily soluble in water, and contains glucose stabilizing ingredients. Compared with other vitamin C derivatives, ascorbyl glucoside has good stability and solubility in solution. In addition, ascorbyl glucoside can be used to lighten skin color and reduce pigmentation of age spots and freckles.

[0042] The term "ergothioneine" is a rare natural chiral amino acid strong oxidant that is easily soluble in water. It has cell physiological protection functions such as cleaning free radicals, detoxification, maintaining DNA biosynthesis, normal cell generation, cell immunity, whitening and anti-aging.

[0043] The term "phenylethyl resorcinol" is an organic compound with the chemical formula C 14 H 14 O2, which appears as a white to light brown powder, is widely used in whitening, freckle removal and anti-aging products.

[0044] The term "niacinamide", also known as nicotinamide, is an amide compound of niacin. It appears as a white crystalline powder. It has the effects of preventing skin roughness, maintaining skin cell health, and promoting skin whitening.

[0045] The term "acetyl glucosamine", also known as N-acyl glucosamine, has the effects of moisturizing, reducing pigmentation, preventing photoaging, and promoting normal exfoliation of aged keratin.

[0046] The term "tetrahydrocurcumin" is a natural functional whitening raw material obtained by hydrogenating curcumin isolated from the rhizome of the ginger plant turmeric. It has obvious antioxidant effects, can effectively inhibit the generation of oxygen free radicals and remove already formed free radicals.

[0047] The term "ellagic acid" is an organic compound with the chemical formula C 14H6O8 is a natural phenolic antioxidant found in many fruits and vegetables.

[0048] The term "glabridin" refers to a flavonoid extracted from Glycyrrhiza glabra.

[0049] The term "punicalagin" is the main component of pomegranate peel polyphenols, which has multiple effects such as antioxidant, anti-cancer, antibacterial, antiviral and anti-inflammatory.

[0050] The term "phloretin", also known as trihydroxyphenol acetone 2,4,6-trihydroxy-3-(4-hydroxyphenyl) phenylacetone, is a pearly white crystalline powder and a natural skin whitening agent distributed in the peel and root bark of juicy fruits such as apples and pears.

[0051] The term "methyl chalcone hesperidin", also known as hesperidin methyl chalcone, has a chemical formula of C 29 H 36 O 15 , has the effect of vitamin C and can be used in whitening and freckle removal products, prevention and red blood repair products.

[0052] The term "glucosyl hesperidin", also known as enzyme-treated hesperidin, is a water-soluble hesperidin derivative that is widely used in food, health products and cosmetics.

[0053] The term "hesperidin" is a flavonoid substance with a dihydroflavonoid oxygen glycoside structure, weakly acidic, and has anti-inflammatory, antioxidant, antibacterial and other biological activities.

[0054] The term "naringin" is the main flavonoid substance in grapefruit. It has anti-inflammatory, antiviral, anti-allergic and analgesic effects.

[0055] The term "resveratrol" is a non-flavonoid polyphenol organic compound with a chemical formula of C 14 H 12 O3.

[0056] The term "ascorbyl tetraisostearate" is a colorless to light yellow substance with a slight characteristic odor. It is highly stable, not easily oxidized, has similar effects to VC, and is easily absorbed by the skin. Its absorption rate is 16.5 times that of water-soluble vitamin C.

[0057] The term "kojic acid" is an organic compound with the chemical formula C6H6O4. It is commonly used in whitening agents, food additives, preservatives, preservatives and colorants.

[0058] The term "glutathione" is composed of glutamic acid, cysteine ​​and amino acids. It has antioxidant effects and is widely used in delaying aging, enhancing immunity, and anti-tumor.

[0059] The term "raspberry glucoside" refers to an active ingredient extracted from raspberry fruit or rhubarb rhizome, which is often used as a skin whitening ingredient.

[0060] The term "succinic acid", also known as succinic acid, is a colorless crystal with a sour taste. It has a certain exfoliating effect, can reduce skin pigmentation, slow down aging and improve skin tone.

[0061] The term "salicylic acid" is an organic acid with a chemical formula of C7H6O3. It is a white crystalline powder and is often used to relieve pain and fever. It also has anti-inflammatory effects. In addition, it can also be used to remove dead skin cells.

[0062] The term "acetyl tyrosine", also known as N-acetyl-L-tyrosine, appears as white crystals or crystalline powder, and its chemical formula is C 11 H 13 NO4.

[0063] The term "diglucosyl gallic acid" has the molecular formula C 19 H 26 O 15 , it has antioxidant, photoprotective, and melanin transfer inhibition effects.

[0064] The term "acetyl glucosamine", also known as N-acyl glucosamine, has the characteristics of moisturizing, reducing pigmentation, resisting photoaging, and promoting normal exfoliation of aging cuticles.

[0065] The term "heparin sodium" refers to a type of heparin in the form of sodium salt, which is currently mainly obtained from the pig small intestinal mucosa. It has the functions of increasing skin vascular permeability, improving microcirculation, anti-inflammatory, anti-allergic, promoting skin nutrition supply, promoting metabolite excretion, and skin health care and maintenance.

[0066] The term "AHA", also known as α-hydroxy acid, specifically includes glycolic acid, lactic acid, malic acid, etc., which can promote the renewal of skin epidermal cells, help improve skin tone, reduce wrinkles, etc.

[0067] The term "BHA", also known as beta-hydroxy acid, specifically includes salicylic acid, which is often used to treat skin problems such as clogged pores and uneven skin texture.

[0068] The term "azelazamide MEA" is a derivative of azelaic acid with the molecular formula C 11 H 21 NO4 has good water solubility.

[0069] The term "potassium 4-methoxysalicylate" has a structure similar to salicylic acid, which can coordinate keratin metabolism, correct abnormal epidermal proliferation, and promote the elimination of melanin.

[0070] The term "polydatin" refers to an extract from the plant Polygonum cuspidatum, which has antioxidant, anti-tumor, anti-inflammatory, neuroprotective, cardioprotective and immunomodulatory abilities.

[0071] The term "sulforaphane" is an isothiocyanate that is hydrolyzed by myrosinase in vivo by glucosinolates, with a chemical formula of C6H 11 NOS2 is a common antioxidant.

[0072] The term "ferulic acid", also known as 4-hydroxy-3-methoxycinnamic acid or 3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid, the term hydroxyphenylpropenoic acid, is a phenolic phytochemical component present in the cell walls of plants. It has the effects of preventing blood lipid oxidation, resisting platelet aggregation and thrombosis, improving cardiovascular and cerebrovascular health, and preventing osteoporosis.

[0073] The term "hydrolyzed conchiolin" refers to an peptide compound obtained by separation and enzymatic hydrolysis of conchiolin from aquatic organisms through bioengineering technology, and has a strong resistance to melanin caused by endothelin.

[0074] The term "EGCG", also known as epigallocatechin gallate, is one of the most effective active ingredients in tea polyphenols and belongs to catechins. It has antibacterial, antiviral, antioxidant, anti-atherosclerotic, anti-thrombotic, anti-angiogenic, anti-inflammatory and anti-tumor effects.

[0075] The term "tartaric acid", also known as 2,3-dihydroxysuccinic acid, has the chemical formula C4H6O6.

[0076] The term "Nine-peptide-1", also known as whitening peptide, is a whitening nonapeptide containing nine amino acids, which is often used to brighten skin and remove spots.

[0077] The term “alool” is an active ingredient of aloe vera, which appears as a pale yellow to brown powder and has anti-inflammatory, UV protection and antibacterial properties.

[0078] The term "dihydromyricetin" is a flavonoid compound whose main component has the effects of scavenging free radicals, anti-oxidation, anti-thrombosis, anti-tumor, and anti-inflammatory.

[0079] The term "papain", also known as papain or papain, is a cysteine ​​protease found in papaya fruit.

[0080] The term "bromelain", also known as pineapple enzyme or bromelain, is a protease extract extracted from pineapple stems.

[0081] The term "sutylase" is a protease isolated from Bacillus subtilis, which has a positive effect on skin keratin metabolism, increasing skin elasticity, etc.

[0082] The term "idebenone" is an organic compound with the chemical formula C 19 H 30 O5 is a yellow crystal or crystalline powder, which has the functions of clearing free radicals, inhibiting lipid peroxidation, inhibiting inflammation, inhibiting DNA damage, photoprotection, and reducing pigmentation.

[0083] The term "astaxanthin" is a chain-breaking antioxidant that has extremely strong antioxidant capacity and inhibits lipid peroxidation caused by free radicals.

[0084] The term "Hydroxyethylpiperazineethanesulfonic acid" is a highly effective biological buffer that can restructure the stratum corneum and promote the metabolism of skin keratinocytes.

[0085] The term "citric acid", also known as citric acid, is an organic weak acid containing 3 hydroxyl groups and has a chemical formula of C6H8O7.

[0086] The term "sodium citrate", also known as trisodium citrate, sodium citrate, and trisodium citrate, has the chemical formula C6H5Na3O7.

[0087] The term "disodium hydrogen phosphate", also known as sodium monohydrogen phosphate, has the chemical formula Na2HPO4.

[0088] The term "sodium dihydrogen phosphate", also known as acid sodium phosphate, has the chemical formula Na2HPO4.

[0089] The term "hydroxyethyl cellulose" is a white or light yellow, odorless, non-toxic fibrous or powdered solid with a chemical formula of (C2H6O2) n .

[0090] The term "hydroxypropyl cellulose" is a semi-synthetic organic compound that is a white or off-white powder.

[0091] The term "hydroxypropyl methylcellulose" is a semisynthetic, inert, viscoelastic polymer.

[0092] The term "Carbomer", also known as polyacrylic acid, hydroxyethylene copolymer, is an important rheology regulator.

[0093] The term "sodium polyacrylate" is a new functional polymer material. It appears as white or light yellow block or powder in solid state and colorless or light yellow viscous liquid in liquid state. Its chemical formula is (C3H3NaO2) n .

[0094] The term "HEPES", also known as 4-hydroxyethylpiperazineethanesulfonic acid, refers to a commonly used zwitterionic buffer.

[0095] The term "aminomethyl propanol", also known as 2-amino-2-methyl-1-propanol, has a chemical formula of C4H 11 NO, which appears as white crystalline blocks or colorless liquid, is often used as a biological stabilizer and pH stabilizer.

[0096] The present disclosure will be described in detail below with reference to the accompanying drawings and in conjunction with embodiments.

[0097] Experimental method description

[0098] Thermal stability test

[0099] (1) Seal the test samples in 50 mL PET bottles and store them in a dark place at a temperature of (50 ± 0.5) °C. Observe the color stability of the test samples every day.

[0100] (2) Regarding the color evaluation of the test samples, the colors of the different compositions were scored, with the color change degree of Comparative Example 9 being 0 points and the color of deionized water (T100) being 10 points.

[0101] Comparative Example

[0102] Among them, the comparative examples are set as comparative example 1, comparative example 2, comparative example 3, comparative example 4, comparative example 5, comparative example 6, comparative example 7, comparative example 8, and comparative example 9. The composition ratio of the experimental samples corresponding to each comparative example is shown in the following Table 1:

[0103] Table 1

[0104]

[0105]

[0106] Among them, the color stability of Comparative Example 1, Comparative Example 2, Comparative Example 3, Comparative Example 4, Comparative Example 5, Comparative Example 6, Comparative Example 7, Comparative Example 8, and Comparative Example 9 at 50° C. can be as follows: Figure 1 As shown, the color stability scores corresponding to Comparative Examples 1-9 are 7, 4, 7, 2, 1, 1, 4, 5, and 0, respectively. Specifically, the appearance state diagrams of the test samples corresponding to Comparative Example 1, Comparative Example 2, and Comparative Example 9 can be referred to respectively. Figure 2 The schematic diagram of the appearance of the test sample corresponding to Comparative Example 1 shown in FIG. Figure 3 The schematic diagram of the appearance of the test sample corresponding to Comparative Example 2 shown in FIG. Figure 4The schematic diagram of the appearance state of the corresponding test sample of Comparative Example 9 shown.Contrast and find that, first, Comparative Example 1 and Comparative Example 8 prove that discoloration can not be completely suppressed when only adding ascorbyl glucoside or thioneine.Secondly, Comparative Example 2, Comparative Example 4, Comparative Example 5, Comparative Example 6 and Comparative Example 7 prove that discoloration can not be completely suppressed when ascorbyl glucoside is combined with other antioxidants (vitamin C ethyl ether, ascorbic acid, ascorbyl glucoside salt, glabridin).

[0107] Example Description

[0108] Among them, the embodiments include embodiment 1, embodiment 2, embodiment 3, embodiment 4, embodiment 5, embodiment 6, embodiment 7, embodiment 8, and embodiment 9. The composition ratio of the experimental samples corresponding to each embodiment is shown in the following Table 2:

[0109] Table 2

[0110]

[0111] Among them, in Example 1, the mass ratio of arbutin, tranexamic acid and color stabilizer is 1:2.5:0.0525; the mass ratio of ascorbyl glucoside to ergothioneine is 20:1.

[0112] In Example 2, the mass ratio of arbutin, tranexamic acid and color stabilizer is 1:2.5:0.505; the mass ratio of ascorbyl glucoside to ergothioneine is 100:1.

[0113] In Example 3, the mass ratio of arbutin, tranexamic acid and color stabilizer is 1:2.5:0.2525; the mass ratio of ascorbyl glucoside to ergothioneine is 10:1.

[0114] In Example 4, the mass ratio of arbutin, tranexamic acid and color stabilizer is 1:5:0.105; the mass ratio of ascorbyl glucoside to ergothioneine is 20:1.

[0115] In Example 5, the mass ratio of arbutin, tranexamic acid and color stabilizer is 1:5:0.505; the mass ratio of ascorbyl glucoside to ergothioneine is 100:1.

[0116] In Example 6, the mass ratio of arbutin, tranexamic acid and color stabilizer is 1:5:0.505; the mass ratio of ascorbyl glucoside to ergothioneine is 10:1.

[0117] In Example 7, the mass ratio of arbutin, tranexamic acid and color stabilizer is 1:0.5:0.0525; the mass ratio of ascorbyl glucoside to ergothioneine is 20:1.

[0118] In Example 8, the mass ratio of arbutin, tranexamic acid and color stabilizer is 1:0.5:0.505; the mass ratio of ascorbyl glucoside to ergothioneine is 100:1.

[0119] In Example 9, the mass ratio of arbutin, tranexamic acid and color stabilizer is 1:0.5:0.2525; the mass ratio of ascorbyl glucoside to ergothioneine is 10:1.

[0120] Among them, the color stability of Example 1, Example 2, Example 3, Example 4, Example 5, Example 6, Example 7, Example 8, and Example 9 at 50° C. can be as follows: Figure 5 As shown, the color stability scores corresponding to Examples 1-9 are 9, 9.5, 10, 9.1, 9.8, 10, 8.9, 9.5, and 9.5, respectively. Specifically, the appearance state diagrams of the test samples corresponding to Example 1 and Example 3 can be referred to respectively. Figure 6 The schematic diagram of the appearance of the test sample corresponding to Example 1 shown, and Figure 7 The schematic diagram of the appearance of the test sample corresponding to Example 3 is shown. By comparison, it is found that Examples 1 to 9 prove that the composition does not change color at all, that is, when the mass ratio of tranexamic acid, arbutin and color stabilizer is 1:0.5-5:0.05-1.0 and the mass ratio of ascorbyl glucoside and ergothioneine is 100:1-10:1, the color change of the combination of arbutin and tranexamic acid can be completely suppressed.

[0121] In addition, Example 10, Example 11, Example 12, Example 13, Example 14 and Example 15 are further provided, and the composition ratios of the experimental samples corresponding to each example are shown in Table 3 below:

[0122] Table 3

[0123]

[0124] Among them, in Example 10, the mass ratio of arbutin, tranexamic acid and color stabilizer is 1:2.5:0.5025; the mass ratio of ascorbyl glucoside to ergothioneine is 200:1.

[0125] In Example 11, the mass ratio of arbutin, tranexamic acid and color stabilizer is 1:2.5:0.0625; the mass ratio of ascorbyl glucoside to ergothioneine is 4:1.

[0126] In Example 12, the mass ratio of arbutin, tranexamic acid and color stabilizer is 1:5:1.005; the mass ratio of ascorbyl glucoside to ergothioneine is 200:1.

[0127] In Example 13, the mass ratio of arbutin, tranexamic acid and color stabilizer is 1:5:0.125; the mass ratio of ascorbyl glucoside to ergothioneine is 4:1.

[0128] In Example 14, the mass ratio of arbutin, tranexamic acid and color stabilizer is 1:0.5:0.5025; the mass ratio of ascorbyl glucoside to ergothioneine is 200:1.

[0129] In Example 15, the mass ratio of arbutin, tranexamic acid and color stabilizer is 1:0.5:0.0625; the mass ratio of ascorbyl glucoside to ergothioneine is 4:1.

[0130] Among them, the color stability of Example 10, Example 11, Example 12, Example 13, Example 14, and Example 15 at 50° C. can be as follows: Figure 8 As shown, the color stability scores corresponding to Examples 10-15 are 10, 9.5, 9.8, 9.2, 10, and 9.5, respectively. By comparison, it is found that Examples 10 to 14 prove that the composition does not change color at all.

[0131] Application Example

[0132] Application Example 1

[0133] The skin whitening product prepared in Application Example 1 is a whitening essence. The formula of the whitening essence is shown in Table 4 below:

[0134] Table 4

[0135]

[0136] Preparation method of whitening essence:

[0137] S1: Heat phase A to 65-75 degrees Celsius and dissolve it evenly.

[0138] S2: Add phase B into the system, stir evenly, and start cooling.

[0139] S3: Cool down to 45±1℃ and add phase C into the system in sequence, stirring to dissolve evenly.

[0140] S4: Cool down to room temperature, test and discharge the product after it is qualified, and obtain the above whitening essence.

[0141] Whitening efficacy test

[0142] Among them, the ultraviolet induced human skin melanization model freckle removal and whitening efficacy test method was used to test the whitening effect of the samples.

[0143] Subject selection

[0144] Among them, qualified subjects are selected according to the inclusion and exclusion criteria to ensure that the final number of valid cases completed in each test area is not less than 30.

[0145] Test substance preparation

[0146] Among them, test product: test sample. Negative control: blackened area blank control. Positive control: 7% ascorbic acid skin external preparation.

[0147] Specific test steps

[0148] Determine the MED of the test site for each subject. Then select each test area at the test site and use a solar simulator to irradiate the same irradiation point once a day at a dose of 0.75 times the MED for 4 consecutive days. On the 5th day after the irradiation, perform visual assessment and instrumental testing of the skin color of each test area, and exclude test areas with poor consistency (areas where the ITA° value differs from the mean of all test areas by more than 5).

[0149] On the same day, the corresponding test objects will be smeared in each blackening test area according to the random table. The staff will smear the test objects in the corresponding test area according to the random table, and the coating area should be no less than 6cm 2 , the coating amount is 2.00±0.05mg / cm 2 . The test article should be applied continuously for at least 4 weeks. Visual assessment and instrumental testing of skin color should be performed and recorded 1 week, 2 weeks, 3 weeks and 4 weeks after application. At each visit point, the L*, a*, and b* values ​​of each test area were measured using a skin colorimeter. Each area was tested three times, and the ITA° value was recorded and calculated. The larger the ITA° value, the lighter the skin color, and vice versa. The ITA° value before the sample was used in the test was A, and the ITA° value after the sample was used was B. The improvement ratio was calculated, (AB) / A*100%, which is the improvement ratio of the product.

[0150] After whitening efficacy testing, the product's 28-day trial test showed an average ITA increase of 12%. Figure 8 The skin imaging diagrams of the whitening test results of Application Example 1 under different spectra show that the skin color becomes significantly lighter after using the test sample over time, which can further prove that the composition has an obvious whitening effect.

[0151] The above descriptions are only some preferred embodiments of the present disclosure and an explanation of the technical principles used. Those skilled in the art should understand that the scope of the invention involved in the embodiments of the present disclosure is not limited to the technical solutions formed by a specific combination of the above-mentioned technical features, but should also cover other technical solutions formed by any combination of the above-mentioned technical features or their equivalent features without departing from the above-mentioned inventive concept. For example, the above-mentioned features are replaced with the technical features with similar functions disclosed in the embodiments of the present disclosure (but not limited to) and the technical solutions formed.

Claims

1. A color-stable whitening composition comprising: Arbutin; Tranexamic acid; A color stabilizer, wherein the color stabilizer comprises ascorbyl glucoside and ergothioneine.

2. The whitening composition according to claim 1, wherein The mass ratio of the arbutin to the tranexamic acid is 1:0.5-5.

3. The whitening composition according to claim 2, wherein The mass ratio of the arbutin to the color stabilizer is 1:0.05-1.

4. The whitening composition according to claim 1, wherein The mass ratio of ascorbyl glucoside to ergothioneine is 10 to 100:

1.

5. The whitening composition according to claim 1, wherein The whitening composition further comprises: one or more of a whitening agent, a pH regulator and a skin feel regulator.

6. The whitening composition according to claim 5, wherein The skin feel regulator includes: one or more of a moisturizer, an emulsifier, a thickener, and a surfactant.

7. A skin whitening product comprising the color-stable whitening composition according to any one of claims 1 to 6.

8. The skin whitening product according to claim 7, wherein: The skin whitening product includes: one or more of water solution, emulsion, cream, ointment, gel and facial mask.

9. Application of ascorbyl glucoside and ergothioneine as color stabilizers in whitening compositions, wherein: The whitening composition comprises arbutin and tranexamic acid.

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