Acne-removing and relapse-preventing composition suitable for acne sensitive skin and application thereof

Abstract

The invention provides an acne-removing and relapse-preventing composition suitable for acne sensitive skin and application of the acne-removing and relapse-preventing composition, and belongs to the technical field of cosmetics. The epigallocatechin gallic acid glucoside, the brazilin, the roselle flower extract, the jujube bark extract, the linseed oil unsaponifiable matter and the guaiacol extract are selected as active ingredients of the acne-removing and relapse-preventing composition and interact with one another, growth of acne-related pathogenic bacteria can be rapidly inhibited, and the skin micro-ecology can be adjusted; skin inflammation in the whole process of acne is effectively inhibited, the effects of preventing and inhibiting inflammation are achieved, the skin barrier is effectively repaired, redness is reduced, meanwhile, the effect of adjusting skin grease balance is achieved, and acne recurrence is prevented; in addition, the acne-removing and relapse-preventing composition also has the effects of removing yellow gas, uniformizing skin color and improving skin roughness, is mild and non-irritating, can be used for sensitive skin, and expands the application range of the acne-removing and relapse-preventing composition.

Description

Technical Field

[0001] The present disclosure relates to the technical field of cosmetics, and in particular to an acne-removing and recurrence-preventing composition suitable for acne-sensitive skin and an application thereof. Background Art

[0002] Acne is a common chronic inflammatory skin disease of the hair follicles and sebaceous glands, mainly occurring in seborrheic areas such as the face, chest, and back. The course of acne is chronic and recurrent, and may lead to infection, pigmentation, and scarring. It can even have a serious negative impact on the patient's quality of life and psychosocial function. The pathogenesis of acne is mainly related to increased sebum secretion, hyperkeratosis of the hair follicles and sebaceous duct epithelium, Propionibacterium acnes, and inflammatory immunity.

[0003] Conventional acne treatments, including drugs, physical therapy, and chemotherapy, all have some serious side effects, such as bacterial resistance, damage to the skin barrier function, and inflammatory pigmentation. Acne itself can also cause damage to the skin barrier function. The application of skin care in the adjuvant treatment of acne has received widespread attention. Due to their safety, good tolerance, and the role of improving damaged skin barriers, most acne products on the market are slow to take effect and the effect is not ideal, which cannot meet the needs of consumers in daily life or special occasions. Secondly, short-term acne products contain acid and sulfur, which stimulate the skin's high immune response, have a ripening effect, and are potentially irritating. They are not friendly to some people with sensitive skin. Importantly, short-term acne products are mostly spot-on products, which are not suitable for long-term maintenance and improvement of acne skin. Not only that, most products ignore acne post-care, which will greatly increase the probability of acne recurrence, and in the long run will increase the damage to the skin barrier, leading to a vicious cycle. Summary of the invention

[0004] The purpose of the present invention is to overcome the deficiencies of the prior art and provide an acne-removing and recurrence-preventing composition suitable for acne-sensitive skin and its application.

[0005] To achieve the above-mentioned purpose, the technical scheme adopted by the present invention is as follows: in the first aspect, a composition for removing acne and preventing recurrence suitable for acne-sensitive skin is provided, wherein the composition for removing acne and preventing recurrence comprises the following components in parts by weight: 0.01-3 parts of epigallocatechin gallate glucoside, 0.001-0.3 parts of brazilian hematoxylin, 1-15 parts of roselle flower extract, 0.1-1 parts of jujube bark extract, 0.01-3 parts of linseed oil unsaponifiable matter, and 1-15 parts of guaiac extract.

[0006] In some embodiments, the acne-recurrence prevention composition comprises the following components in parts by weight: 0.05-1 part of epigallocatechin gallate glucoside, 0.005-0.1 part of brazilian hematoxylin, 3-10 parts of roselle flower extract, 0.1-0.5 part of jujube tree bark extract, 0.05-1 part of linseed oil unsaponifiable matter, and 1-8 parts of guaiac extract.

[0007] In some embodiments, the acne-recurrence prevention composition comprises the following components in parts by weight: 0.5-1 part of epigallocatechin gallate glucoside, 0.01-0.1 part of brazilian hematoxylin, 3-8 parts of roselle flower extract, 0.15-0.5 part of jujube tree bark extract, 0.08-0.5 part of linseed oil unsaponifiable matter, and 2-5 parts of guaiac wood extract.

[0008] In some embodiments, the preparation method of the roselle flower extract is: adding roselle flowers to an acidified ethanol solution for ultrasonic extraction, after the extraction is completed, performing solid-liquid separation, and drying the obtained filtrate to obtain the roselle flower extract;

[0009] In some embodiments, the preparation method of the Zizyphus jojoba bark extract is as follows: adding Zizyphus jojoba bark to an ethanol aqueous solution for extraction, performing solid-liquid separation after the extraction, and drying the obtained filtrate to obtain the Zizyphus jojoba bark extract.

[0010] In some embodiments, in the method for preparing the roselle flower extract, the water content of the roselle flower is 4-6%;

[0011] and / or, the average particle size of the roselle flower is ≤150 μm;

[0012] and / or, the solid-to-liquid ratio of the roselle flower to the acidified ethanol solution is 1 g: 30-40 mL;

[0013] And / or, the frequency of the ultrasonic extraction is 120-160 Hz;

[0014] And / or, the ultrasonic extraction time is 25-35min;

[0015] And / or, the temperature of the ultrasonic extraction is 45-55°C;

[0016] And / or, the pH of the acidified ethanol solution is 2.5-3.5.

[0017] In some embodiments, in the method for preparing the jujube tree bark extract, the solid-to-liquid ratio of the jujube tree bark to the ethanol aqueous solution is 1 g: 10-20 mL;

[0018] And / or, the volume percentage of ethanol in the ethanol aqueous solution is 65-75%;

[0019] And / or, the extraction method is one of leaching, reflux extraction and ultrasonic extraction.

[0020] In a second aspect, the invention provides the use of the acne-removing and recurrence-preventing composition in the preparation of cosmetics.

[0021] In a third aspect, a cosmetic is provided, the cosmetic comprising the acne-eliminating and recurrence-preventing composition, wherein the content of the acne-eliminating and recurrence-preventing composition in the cosmetic is 0.1-3 wt %.

[0022] In some embodiments, the cosmetic is an anti-acne lotion, and the anti-acne lotion includes the following components in percentage by weight: 0.1-3% of an anti-acne recurrence prevention composition, 0.05-5% of a thickener, 3-20% of a moisturizer, 0.5-10% of an emulsifier, 0.2-5% of a preservative, 0.05-0.1% of a pH adjuster, and the remainder is water.

[0023] In some embodiments, the thickener includes at least one of xanthan gum, carbomer, ammonium acrylamide dimethyl taurate / VP copolymer, and cellulose;

[0024] And / or, the moisturizing agent includes at least one of glycerin, butylene glycol, and sodium hyaluronate;

[0025] And / or, the emulsifier includes at least one of coconut oil alcohol-caprylate / caprate, polydimethylsiloxane, hydrogenated palm kernel oil, cetearyl alcohol, polyglyceryl-6 distearate, and polymethyl silsesquioxane;

[0026] And / or, the preservative includes at least one of 1,3-propylene glycol, 1,2-hexanediol, and p-hydroxyacetophenone;

[0027] And / or, the pH regulator includes at least one of arginine and disodium ethylenediaminetetraacetate.

[0028] Compared with the prior art, the beneficial effects of the present invention are as follows: the present invention selects epigallocatechin gallate glucoside, brazilian hematoxylin, roselle flower extract, jujube bark extract, linseed oil unsaponifiable matter and guaiac extract as active ingredients of the acne-removing and recurrence-preventing composition, which interact with each other to quickly inhibit the growth of acne-related pathogens and regulate the skin microecology; effectively inhibit skin inflammation throughout the entire process of acne, play a role in preventing and inhibiting inflammation, effectively repair the skin barrier, reduce redness, and at the same time have the effect of regulating the balance of skin oils and fats, and prevent acne recurrence; in addition, the acne-removing and recurrence-preventing composition also has the effect of removing yellowness, evenly dissolving skin color, and improving skin roughness, and the acne-removing and recurrence-preventing composition is mild and non-irritating, and can be used for sensitive skin, thereby expanding the application range of acne-removing products. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1This is a graph showing the acne removal test results using the lotion of Application Example 1 on days D0 and D7 in Effect Example 3;

[0030] Figure 2 This is a graph showing the acne removal test results on days D0 and D7 using the emulsion in comparative application example 1 in effect example 3. DETAILED DESCRIPTION

[0031] In order to facilitate understanding of the present disclosure, the present disclosure will be described more fully below. However, the present disclosure can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the understanding of the disclosure of the present disclosure more thorough and comprehensive.

[0032] As used herein:

[0033] "Prepared from" is synonymous with "comprising." As used herein, the terms "comprising," "including," "having," "containing," or any other variation thereof, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises the listed elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.

[0034] The conjunction "consisting of excludes any unspecified element, step, or component. If used in a claim, this phrase renders the claim closed-ended so that it does not include materials other than those described, except for conventional impurities associated therewith. When the phrase "consisting of" appears in a clause of the body of a claim rather than immediately following the subject matter, it limits only the elements described in that clause; other elements are not excluded from the claim as a whole.

[0035] When amount, concentration or other value or parameter is represented by range, preferred range or a series of upper preferred value and lower preferred value, this should be understood as specifically disclosing all ranges formed by any pairing of any range upper limit or preferred value and any range lower limit or preferred value, regardless of whether the range is disclosed separately. For example, when disclosing range "1-5", described range should be interpreted as including range "1-4", "1-3", "1-2", "1-2 and 4-5", "1-3 and 5" etc. When numerical range is described in this article, unless otherwise stated, the range is intended to include its end value and all integers and fractions within the range.

[0036] In these examples, parts and percentages are by mass unless otherwise indicated.

[0037] "Parts by mass" refers to the basic unit of measurement for expressing the mass ratio of multiple components. 1 part can represent any unit mass, such as 1g or 2.689g. If we say that the mass of component A is a parts and the mass of component B is b parts, it means the ratio of the mass of component A to the mass of component B is a:b. Alternatively, it means that the mass of component A is aK and the mass of component B is bK (K is an arbitrary number, indicating a multiple factor). It should not be misunderstood that, unlike the mass parts, the sum of the mass of all components is not limited to 100 parts.

[0038] "And / or" is used to indicate that one or both of the situations described may occur, for example, A and / or B includes (A and B) and (A or B). In a first aspect, a composition for removing acne and preventing recurrence suitable for acne-sensitive skin is provided, the composition for removing acne and preventing recurrence comprising the following components in parts by weight: 0.01-3 parts of epigallocatechin gallate glucoside, 0.001-0.3 parts of brazilian hematoxylin, 1-15 parts of roselle flower extract, 0.1-1 parts of jujube bark extract, 0.01-3 parts of linseed oil unsaponifiable matter, and 1-15 parts of guaiac extract.

[0039] Specifically, the weight portion of the epigallocatechin gallate glucoside can be, but is not limited to, 0.01, 0.05, 0.1, 0.2, 0.5, 0.7, 1, 1.3, 1.5, 1.8, 2, 2.2, 2.5, 2.7, or 3 parts, preferably 0.05-1 part, and more preferably 0.5-1 part.

[0040] Specifically, the weight portion of the brazilin can be but is not limited to 0.001, 0.005, 0.01, 0.03, 0.05, 0.07, 0.1, 0.12, 0.15, 0.18, 0.2, 0.22, 0.25, 0.27, 0.3, preferably 0.005-0.1, more preferably 0.01-0.1.

[0041] Specifically, the weight proportion of the roselle flower extract can be, but is not limited to, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts, 10 parts, 10.5 parts, 11 parts, 11.5 parts, 12 parts, 12.5 parts, 13 parts, 13.5 parts, 14 parts, 14.5 parts, and 15 parts; preferably, 3-10 parts, and more preferably, 3-8 parts.

[0042] Specifically, the weight portion of the jujube tree bark extract can be but is not limited to 0.1 part, 0.15 part, 0.2 part, 0.25 part, 0.3 part, 0.35 part, 0.4 part, 0.45 part, 0.5 part, 0.55 part, 0.6 part, 0.65 part, 0.7 part, 0.75 part, 0.8 part, 0.85 part, 0.9 part, 0.95 part, 1 part; preferably 0.1-0.5 part, more preferably 0.15-0.5 part.

[0043] Specifically, the weight proportion of the unsaponifiable matter of linseed oil can be, but is not limited to, 0.01, 0.05, 0.1, 0.3, 0.5, 0.7, 1, 1.2, 1.5, 1.7, 2, 2.3, 2.5, 2.8, or 3 parts; preferably, 0.05-1 part, and more preferably, 0.08-0.5 part.

[0044] Specifically, the weight proportion of the guaiac extract can be but is not limited to 1 part, 1.2 parts, 1.5 parts, 1.7 parts, 2 parts, 2.3 parts, 2.5 parts, 2.8 parts, 3 parts, 3.5 parts, 4 parts, 4.3 parts, 4.5 parts, 4.8 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 9 parts, 10 parts, 11 parts, 11.5 parts, 12 parts, 13 parts, 14 parts, 14.5 parts, 15 parts; preferably 1-8 parts, more preferably 2-5 parts.

[0045] The present invention selects epigallocatechin gallate glucoside, brazilian hematoxylin, roselle flower extract, jujube bark extract, linseed oil unsaponifiable matter and guaiac extract as active ingredients of the acne-removing and recurrence-preventing composition, which interact with each other to quickly inhibit the growth of acne-related pathogens and regulate the skin microecology; effectively inhibit skin inflammation throughout the entire process of acne, play a role in preventing and inhibiting inflammation, effectively repair the skin barrier, reduce redness, and at the same time have the effect of regulating the balance of skin oils and preventing acne recurrence; in addition, the acne-removing and recurrence-preventing composition also has the effect of removing yellowness, evenly dissolving skin color, and improving skin roughness, and the acne-removing and recurrence-preventing composition is mild and non-irritating, and can be used for sensitive skin, thereby expanding the application range of the acne-removing and recurrence-preventing composition.

[0046] Specifically, epigallocatechin gallate glucoside can effectively scavenge free radicals, slow down cell aging, protect cells from damage, has high anti-inflammatory properties, effectively improves acne and repairs the skin; brazilian hematoxylin can accelerate the improvement and healing of acne; roselle flower extract can protect the skin from external interference, and has antioxidant and antibacterial effects; jujube bark extract has anti-inflammatory, antimicrobial and immunomodulatory effects; linseed oil unsaponifiable matter mainly includes linolenic acid, linolenic acid, linolenic acid, oleic acid, stearic acid and palmitic acid, which have anti-inflammatory and synergistic effects, and can also promote the metabolism of skin cells and enhance the elasticity and radiance of the skin; guaiac wood extract is rich in lignin, quinones, saponins, sesquiterpenes and triterpenes, and has anti-inflammatory, antiviral, antibacterial, astringent and repairing effects.

[0047] Specifically, the content of each component in the acne removing and recurrence preventing composition will affect the overall performance of the acne removing and recurrence preventing composition. When the weight proportions of epigallocatechin gallate glucoside, brazilian hematoxylin, roselle flower extract, jujube tree bark extract, linseed oil unsaponifiable matter and guaiac wood extract are within the preferred range, the obtained acne removing and recurrence preventing composition has better acne removing, repairing and oil controlling effects.

[0048] In some embodiments, the preparation method of the roselle flower extract is: adding roselle flowers to an acidified ethanol solution for ultrasonic extraction, after the extraction is completed, performing solid-liquid separation, and drying the obtained filtrate to obtain the roselle flower extract;

[0049] In the preparation method of the roselle flower extract, each parameter satisfies at least one of the following:

[0050] Specifically, the water content of the roselle flower is 4-6%; for example, it can be but not limited to 4%, 4.2%, 4.4%, 4.6%, 4.8%, 5%, 5.3%, 5.5%, 5.7%, 6%;

[0051] In order to obtain the roselle flowers with the above water content, the roselle flowers need to be dried; the present disclosure does not make any specific limitation on the drying method, as long as the water content of the roselle flowers can reach 4-6%, such as air drying, oven drying, vacuum freeze drying; in order to retain the content of active ingredients in the roselle flowers, the present disclosure selects vacuum freeze drying.

[0052] Specifically, the drying steps of roselle flowers are as follows:

[0053] After pre-freezing the roselle flowers, they are placed in a vacuum freeze drying oven with a vacuum degree of 80-100 Pa and a temperature of (-45°C)-(-40°C), heated to 38-42°C at a heating rate of 2-3°C / min, kept warm for 10-14h, then heated to 48-52°C at a heating rate of 0.2-0.4°C / min, kept warm for 1.5-2.5h, then cooled to 18-22°C, and kept warm until the moisture content of the roselle flowers is 4-6%.

[0054] Drying the roselle flower in a multi-stage heating and cooling manner can retain the effective active ingredients in the roselle flower to the maximum extent, thereby improving the acne removal, barrier repair, and oil secretion reduction effects of the acne removal and recurrence prevention composition.

[0055] Specifically, the average particle size of the roselle flower is ≤150 μm; for example, it can be but not limited to 1 μm, 5 μm, 10 μm, 30 μm, 50 μm, 70 μm, 90 μm, 110 μm, 130 μm, 150 μm;

[0056] Specifically, the solid-liquid ratio of the roselle flower and the acidified ethanol solution is 1g:30-40mL; for example, it can be but not limited to 1g:30mL, 1g:32mL, 1g:34mL, 1g:36mL, 1g:38mL, 1g:40mL;

[0057] Specifically, the frequency of the ultrasonic extraction is 120-160 Hz; for example, it can be but not limited to 120 Hz, 125 Hz, 130 Hz, 135 Hz, 140 Hz, 145 Hz, 150 Hz, 155 Hz, 160 Hz;

[0058] Specifically, the ultrasonic extraction time is 25-35 min; for example, it can be but not limited to 25 min, 27 min, 29 min, 31 min, 33 min, 35 min;

[0059] Specifically, the temperature of the ultrasonic extraction is 45-55°C; for example, it can be but not limited to 45°C, 47°C, 49°C, 51°C, 53°C, 55°C;

[0060] Specifically, the pH of the acidified ethanol solution is 2.5-3.5; for example, it can be but not limited to 2.5, 2.7, 2.9, 3.1, 3.3, 3.5.

[0061] In some embodiments, the acidified ethanol solution is prepared by adding hydrochloric acid to an ethanol aqueous solution and mixing the mixture uniformly to obtain an acidified ethanol solution with a pH of 2.5-3.5.

[0062] Specifically, the amount of hydrochloric acid added is not specifically limited in the present disclosure, as long as the pH of the acidified ethanol solution can be made to be 2.5-3.5.

[0063] Specifically, the volume fraction of ethanol in the ethanol aqueous solution is 50-70%, for example, it can be 50%, 53%, 55%, 58%, 60%, 62%, 65%, 67%, or 70%.

[0064] In some embodiments, the preparation method of the Zizyphus jojoba bark extract is as follows: adding Zizyphus jojoba bark to an ethanol aqueous solution for extraction, performing solid-liquid separation after the extraction, and drying the obtained filtrate to obtain the Zizyphus jojoba bark extract.

[0065] In the preparation method of the jujube tree bark extract, each parameter satisfies at least one of the following:

[0066] Specifically, the solid-liquid ratio of the jujube tree bark and the ethanol aqueous solution is 1g:10-20mL; for example, it can be but not limited to 1g:10mL, 1g:12mL, 1g:14mL, 1g:16mL, 1g:18mL, 1g:20mL;

[0067] Specifically, the volume percentage of ethanol in the ethanol aqueous solution is 50-70%; for example, it can be 50%, 53%, 55%, 58%, 60%, 62%, 65%, 67%, 70%;

[0068] Specifically, the extraction method is one of leaching, reflux extraction and ultrasonic extraction.

[0069] Specifically, the temperatures of leaching, reflux extraction, and ultrasonic extraction are each independently 55-75°C, for example, 55°C, 57°C, 59°C, 61°C, 63°C, 65°C, 67°C, 69°C, 71°C, 73°C, 75°C;

[0070] The extraction time is 40-56 hours, for example, but not limited to 40 hours, 44 hours, 48 ​​hours, 52 hours, 56 hours;

[0071] The reflux extraction time is 4-8 hours, for example, it can be but not limited to 4 hours, 5 hours, 6 hours, 7 hours, 8 hours;

[0072] The time of ultrasonic extraction is 1-2h; the power of ultrasonic extraction is 200-300W.

[0073] Specifically, the roselle flower extract and / or zizyphus jojoba bark extract prepared by the above method can further improve the acne removal, repair and oil control effects of the acne removal and recurrence prevention composition.

[0074] In the preparation process of the roselle flower extract and the jujube bark extract, the method of solid-liquid separation is not particularly limited, as long as the solid and the liquid can be separated, such as filtration and centrifugation; in order to shorten the preparation time of the roselle flower extract and the jujube bark extract, the present invention selects centrifugation as the method of solid-liquid separation.

[0075] Specifically, the centrifugal speed is 3000-5000 r / min, and the centrifugal time is 10-20 min.

[0076] Those skilled in the art can use means known in the art to evenly mix epigallocatechin gallate glucoside, brazilian hematoxylin, roselle flower extract, jujube tree bark extract, linseed oil unsaponifiable matter and guaiac extract to obtain an acne-removing and recurrence-preventing composition, such as mechanical stirring, homogenization, or ultrasound.

[0077] Specifically, the preparation method of the acne-removing and recurrence-preventing composition comprises the following steps: fully mixing epigallocatechin gallate glucoside, brazilian hematoxylin, roselle flower extract, jujube tree bark extract, linseed oil unsaponifiable matter and guaiac wood extract to obtain the acne-recurring and recurrence-preventing composition.

[0078] After mixing, a uniform and stable acne-removing and recurrence-preventing composition is obtained, and the effective ingredients are fully mixed, which is conducive to the full release of the active ingredients.

[0079] In a second aspect, the invention provides the use of the acne-removing and recurrence-preventing composition in the preparation of cosmetics.

[0080] In a third aspect, a cosmetic is provided, the cosmetic comprising the acne-eliminating and recurrence-preventing composition, wherein the content of the acne-eliminating and recurrence-preventing composition in the cosmetic is 0.1-3 wt %.

[0081] The content of the acne-removing and recurrence-preventing composition in the cosmetic can be but is not limited to 0.1wt%, 0.3wt%, 0.5wt%, 0.7wt%, 0.9wt%, 1.2wt%, 1.4wt%, 1.6wt%, 1.8wt%, 2wt%, 2.3wt%, 2.5wt%, 2.8wt%, 3wt%.

[0082] Adding a specific proportion of the acne-removing and recurrence-preventing composition to cosmetics can bring good acne-removing, repairing and oil-controlling effects to the cosmetics. When the cosmetics of the present application contain less than 0.1wt% of the acne-removing and recurrence-preventing composition of the present application, sufficient acne-removing or repairing or oil-controlling effects cannot be expected, and when it contains more than 3wt%, allergies and other undesirable reactions may occur or there may be problems with skin safety.

[0083] In addition to using the acne-recurrence prevention composition as an active ingredient, the ingredients contained in the cosmetic composition of the present invention also include ingredients commonly used in cosmetic compositions, such as conventional adjuvants, such as antioxidants, stabilizers, solubilizers, vitamins, colorants, pigments, and fragrances and carriers.

[0084] The cosmetic composition of the present invention can be prepared as any preparation conventionally prepared in the art, and can be formulated into, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, detergents containing surfactants, oils, powder foundations, emulsion foundations, wax foundations, sprays, etc., but the present invention is not limited thereto. More specifically, the cosmetic composition of the present invention can be prepared into the following preparations: moisturizing lotions, nourishing lotions, nourishing creams, massage creams, essences, facial masks, eye creams, cleansing creams, cleansing foams, cleansing waters, moisturizing creams, fermented creams, ampoules, shampoos, conditioners, sprays or powders.

[0085] When the preparation of the present invention is a paste, cream or gel, at least one selected from animal oil, vegetable oil, wax, paraffin, starch, tragacanth gum, cellulose derivatives, polyethylene glycol, silicone, bentonite, silicon dioxide, talc and zinc oxide can be used as a carrier component.

[0086] When the preparation of the present invention is a powder or spray, lactose, talc, silicon dioxide, aluminum hydroxide, calcium silicate or polyamide powder can be used as a carrier component. In particular, when the preparation of the present invention is a spray, a propellant (such as chlorofluorocarbons, propane / butane or dimethyl ether) can be additionally included.

[0087] When the preparation of the present invention is a solution or emulsion, a solvent, a solubilizer or an emulsifier may be used as a carrier component. For example, at least one selected from the group consisting of water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, butylene glycol, 1,3-butyl glycol oil, polyoxyethylene hydrogenated castor oil, glycerin, glycerol, fatty esters, phenoxyethanol, triethanolamine, polyethylene glycol, beeswax, polysorbate 60, sorbitan sesquioleate, paraffin, sorbitan stearate, glyceryl monostearate (lipophilic), stearic acid, glyceryl stearate / PEG-400 stearate, carboxy polymer, sitosterol, polyglyceryl 2-oleate, ceramide, cholesterol, steareth-4, dicetyl phosphate, macadamia oil, carboxyvinyl polymer, xanthan gum, and fatty acid ester of sorbitan can be used.

[0088] When the preparation of the present invention is a suspension, at least one selected from the following can be used as a carrier component: a liquid diluent such as water, ethanol, glycerol, butylene glycol or propylene glycol; a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitan esters and polyoxyethylene sorbitan esters, microcrystalline cellulose, hydroxyethylcellulose, sodium hyaluronate, phenoxyethanol, aluminum metahydroxide, bentonite, stearic acid, cetyl alcohol, glyceryl monostearate, polyoxyethylene sorbitan monostearate, sorbitan sesquioleate, glyceryl monostearate / glyceryl stearate / polyoxyethylene stearate, wax, paraffin, squalane, caprylic / capric triglyceride, carboxyvinyl polymer, triethanolamine, agar and tragacanth gum.

[0089] When the preparation of the present invention is a surfactant-containing cleanser, at least one selected from the following can be used as a carrier component: fatty alcohol sulfates, fatty alcohol ether sulfates, sulfosuccinic acid monoesters, isethionates, imidazolinium derivatives, methyl taurates, sarcosinates, fatty acid amide ether sulfates, alkylamido betaines, fatty alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives and ethoxylated glyceryl fatty acid esters.

[0090] In some embodiments, the cosmetic is an anti-acne lotion, and the anti-acne lotion includes the following components in percentage by weight: 0.1-3% of an anti-acne recurrence prevention composition, 0.05-5% of a thickener, 3-20% of a moisturizer, 0.5-10% of an emulsifier, 0.2-5% of a preservative, 0.05-0.1% of a pH adjuster, and the remainder is water.

[0091] Specifically, the mass percentage of the acne-removing and recurrence-preventing composition can be, but is not limited to, 0.1%, 0.3%, 0.5%, 0.7%, 1.1%, 1.5%, 1.8%, 2%, 2.2%, 2.4%, 2.6%, 2.8%, 3%;

[0092] Specifically, the mass percentage of the thickener may be, but is not limited to, 0.05%, 0.1%, 0.3%, 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%;

[0093] Specifically, the mass percentage of the moisturizing agent may be, but is not limited to, 3%, 5%, 7%, 9%, 11%, 13%, 15%, 17%, 20%;

[0094] Specifically, the mass percentage of the emulsifier may be, but is not limited to, 0.5%, 1%, 1.5%, 3%, 4%, 5%, 7%, 8%, 10%;

[0095] Specifically, the mass percentage of the preservative may be, but is not limited to, 0.2%, 0.5%, 1%, 1.5%, 2%, 3%, 4%, 5%;

[0096] Specifically, the mass percentage of the pH adjuster may be, but is not limited to, 0.05%, 0.08%, or 0.1%.

[0097] In some embodiments, the thickener includes at least one of xanthan gum, carbomer, ammonium acrylamide dimethyl taurate / VP copolymer, and cellulose;

[0098] In some embodiments, the moisturizer includes at least one of glycerin, butylene glycol, and sodium hyaluronate;

[0099] In some embodiments, the emulsifier includes at least one of coconut oil alcohol-caprylate / caprate, polydimethylsiloxane, hydrogenated palm kernel oil, cetearyl alcohol, polyglyceryl-6 distearate, and polymethylsilsesquioxane;

[0100] In some embodiments, the preservative includes at least one of 1,3-propylene glycol, 1,2-hexanediol, and p-hydroxyacetophenone;

[0101] In some embodiments, the pH adjuster includes at least one of arginine and disodium edetate.

[0102] The cosmetics of the present invention can be prepared by any suitable method known in the art. For example, the cosmetics can be prepared using equipment such as a dissolving tank, an emulsifying pot, a disperser, and a delivery pump commonly used in the cosmetics field according to processes known in the art. For example, a water-soluble substance can be first put into an aqueous phase dissolving pot, and an oil-soluble substance (such as a sunscreen, grease) can be put into an oil phase dissolving pot, and the temperature of the two pots can be heated to about 80°C, respectively. For raw materials that are easy to agglomerate, they can be pre-dispersed with a disperser; such as powder-containing substances (such as zinc oxide and titanium dioxide), they can be dispersed with a suitable solvent and a dispersant and homogenized for 5-10 minutes, and the oil phase is added and homogenized again for 5-10 minutes; after homogenization is completed, the oil phase and the water phase are delivered to the emulsifying pot for homogenization and emulsification for about 5-15 minutes; after emulsification is completed, the temperature of the material body is reduced to room temperature, and optionally, flavors, preservatives, etc. are added, and the pH of the product is adjusted as needed; after the relevant test indicators are qualified, the material can be filled and discharged.

[0103] The above preparation process is merely exemplary, and those skilled in the art can increase, decrease or adjust it according to the dosage form requirements to prepare various dosage forms such as spray, emulsion, gel / jelly, cream, cushion / foundation, etc.

[0104] In order to further understand the present application, the antioxidant composition of the present application, its preparation method and effect are further described in detail below in conjunction with specific examples. All raw materials involved in the present application can be obtained through commercial purchase.

[0105] The raw materials used in the embodiments and comparative examples are described below, but are not limited to these materials:

[0106] The preparation method of roselle pollen is as follows: the roselle flower is pre-frozen for 3 hours and then placed in a vacuum freeze drying box with a vacuum degree of 80Pa and a cold trap temperature of -40°C, the heating plate is heated to 40°C after 30 minutes, kept warm for 12 hours, then heated to 50°C after 30 minutes, kept warm for 2 hours, then cooled to 20°C after 30 minutes, and the drying is stopped when the moisture content of the roselle flower is 5%, the roselle flower is crushed, passed through a 100-mesh sieve, and the sieved material is the roselle pollen, which is placed in a dryer for standby use.

[0107] The acidified ethanol solution 1 is homemade, and its preparation method is as follows: hydrochloric acid is added to an ethanol aqueous solution with a volume fraction of 60%, and mixed evenly to obtain an acidified ethanol solution 1 with a pH of 3;

[0108] The acidified ethanol solution 2 is homemade, and its preparation method is as follows: hydrochloric acid is added to an ethanol aqueous solution with a volume fraction of 50%, and mixed evenly to obtain an acidified ethanol solution 2 with a pH of 3;

[0109] The acidified ethanol solution 3 is homemade, and its preparation method is as follows: hydrochloric acid is added to an ethanol aqueous solution with a volume fraction of 70%, and mixed evenly to obtain an acidified ethanol solution 3 with a pH of 3;

[0110] The roselle flower extract 1 is homemade, and its preparation method is as follows: adding roselle pollen to acidified ethanol solution 1, the solid-liquid ratio of roselle pollen to acidified ethanol solution 1 is 1g:35mL, extracting for 30min under 140kHz, 50℃ ultrasound, repeating the extraction 3 times, after the extraction, centrifuging the obtained product at 3000r / min for 15min, rotating and concentrating the supernatant to remove ethanol, and obtaining the roselle flower extract 1;

[0111] Roselle flower extract 2 is homemade, and its preparation method is as follows: Roselle pollen is added to acidified ethanol solution 2, the solid-liquid ratio of Roselle pollen to acidified ethanol solution 2 is 1g:35mL, extraction is carried out under 120kHz, 50℃ ultrasonic wave for 30min, and the extraction is repeated 3 times. After the extraction is completed, the obtained product is centrifuged at 3000r / min for 15min, the supernatant is taken, and the supernatant is concentrated by rotation to remove ethanol, so as to obtain Roselle flower extract 2;

[0112] Roselle flower extract 3 is homemade, and its preparation method is as follows: Roselle pollen is added to acidified ethanol solution 3, the solid-liquid ratio of Roselle pollen to acidified ethanol solution 3 is 1g:35mL, extraction is performed under 160kHz, 50℃ ultrasonic wave for 30min, the extraction is repeated 3 times, after the extraction is completed, the obtained product is centrifuged at 3000r / min for 15min, the supernatant is concentrated by rotation to remove ethanol, and the Roselle flower extract 3 is obtained;

[0113] Ziziphus jojoba bark extract 1 is homemade, and its preparation method is as follows:

[0114] Take commercially available jujube bark, dry it to constant weight, crush it, pass it through a 100-mesh sieve, collect the sieve underfill, weigh 1 g of the sieve underfill powder, add it to 15 mL of 70% ethanol solution, and immerse it at 60° C. for 48 hours. After the immersion is completed, filter it, collect the filtrate, and concentrate it under reduced pressure to dry it to obtain jujube bark extract 1;

[0115] Ziziphus jojoba bark extract 2 is homemade, and its preparation method is as follows:

[0116] Take commercially available jujube bark, dry it to constant weight, crush it, pass it through a 100-mesh sieve, collect the sieve residue, weigh 1 g of the sieve residue powder and add it to 15 mL of 70% ethanol solution, reflux extract at 60° C. for 6 h, filter it after the extraction, collect the filtrate and concentrate it under reduced pressure to dry it, to obtain jujube bark extract 2;

[0117] Ziziphus jojoba bark extract 3 is homemade, and its preparation method is as follows:

[0118] Take commercially available jujube bark, dry it to constant weight, crush it, pass it through a 100-mesh sieve, collect the sieve residue, weigh 1 g of the sieve residue powder and add it to 15 mL of 70% ethanol solution, perform ultrasonic extraction for 60 min at a temperature of 60°C and an ultrasonic power of 266 W, filter it after the ultrasonic extraction, collect the filtrate, and concentrate and dry it under reduced pressure to obtain jujube bark extract 3;

[0119] Epigallocatechin Gallate Glucoside: Trade Name: EGCG, manufacturer: Givaudan;

[0120] Brazilian hematoxylin: from hematoxylin, 98%, manufacturer: Bailingwei;

[0121] Unsaponifiable matter of linseed oil: Trade name: Manufacturer: Aoyuan;

[0122] Guaiac wood extract: brand L2-DZ-SCB3675-X, manufacturer: Zhenghe.

[0123] Examples 1-6 and Comparative Examples 1-6

[0124] The present invention provides an acne-removing and recurrence-preventing composition suitable for acne-sensitive skin, and the components of the acne-removing and recurrence-preventing composition are shown in Table 1;

[0125] The preparation method of the acne-removing and recurrence-preventing composition of Examples 1-6 and Comparative Examples 1-6 is as follows: the components are uniformly mixed according to the weight parts in Table 1 to obtain the acne-recurrence-preventing composition.

[0126] Table 1

[0127]

[0128]

[0129] Example 7

[0130] The embodiment of the present invention provides an acne-removing and recurrence-preventing composition suitable for acne-sensitive skin. The acne-recurrence-preventing composition of this embodiment is different from that of Example 1 only in that the roselle flower extract 1 is replaced by the roselle flower extract 2.

[0131] Example 8

[0132] The embodiment of the present invention provides an acne-removing and recurrence-preventing composition suitable for acne-sensitive skin. The acne-removing and recurrence-preventing composition of this embodiment is different from that of Example 1 only in that Roselle flower extract 1 is replaced by Roselle flower extract 3.

[0133] Example 9

[0134] The embodiment of the present invention provides an acne-removing and recurrence-preventing composition suitable for acne-sensitive skin. The acne-removing and recurrence-preventing composition of this embodiment is different from that of Embodiment 1 only in that Ziziphus joazeiro bark extract 2 replaces Ziziphus joazeiro bark extract 1.

[0135] Example 10

[0136] The embodiment of the present invention provides an acne-removing and recurrence-preventing composition suitable for acne-sensitive skin. The acne-removing and recurrence-preventing composition described in this embodiment is different from that in Embodiment 1 only in that Ziziphus joazeiro bark extract 3 is used to replace Ziziphus joazeiro bark extract 1.

[0137] Comparative Example 7

[0138] The embodiment of the present invention provides an acne-removing and recurrence-preventing composition suitable for acne-sensitive skin. The acne-recurrence-preventing composition described in this comparative example is different from that in Example 1 only in that epigallocatechin gallate is used instead of epigallocatechin gallate glucoside.

[0139] Comparative Example 8

[0140] The embodiment of the present invention provides an acne-removing and recurrence-preventing composition suitable for acne-sensitive skin. The acne-recurrence-preventing composition described in this comparative example is different from that in Example 1 only in that acacetin is used instead of brazilian hematoxylin.

[0141] Comparative Example 9

[0142] The embodiment of the present invention provides an acne-removing and recurrence-preventing composition suitable for acne-sensitive skin. The acne-recurrence-preventing composition described in this comparative example is different from that in Example 1 only in that hibiscus extract is used instead of roselle flower extract 1.

[0143] Comparative Example 10

[0144] The embodiment of the present invention provides an acne-removing and recurrence-preventing composition suitable for acne-sensitive skin. The acne-recurring and recurrence-preventing composition described in this comparative example is different from that in Example 1 only in that Magnolia bark extract is used instead of Ziziphus joazeiro bark extract 1.

[0145] Comparative Example 11

[0146] The embodiment of the present invention provides an acne-removing and recurrence-preventing composition suitable for acne-sensitive skin. The acne-recurrence-preventing composition described in this comparative example is different from that in Example 1 only in that unsaponifiable matter of olive oil is used instead of unsaponifiable matter of linseed oil.

[0147] Comparative Example 12

[0148] The embodiment of the present invention provides an acne-removing and recurrence-preventing composition suitable for acne-sensitive skin. The acne-recurring and recurrence-preventing composition described in this comparative example is different from that in Example 1 only in that Tetrana oleracea extract is used instead of Guaiacum truncatum extract.

[0149] Application examples 1-11, comparative application examples 1-12 and blank application examples

[0150] The application examples, comparative application examples and blank application examples of the present invention provide an acne-removing lotion, the components (mass percentage) of the acne-removing lotion are shown in Table 2; wherein the acne-removing and anti-recurrence compositions used in application examples 1-10 are respectively the acne-recurring and anti-recurrence compositions prepared in embodiments 1-10, and the acne-recurring and anti-recurrence compositions used in comparative application examples 1-12 are respectively the acne-recurring and anti-recurrence compositions prepared in comparative examples 1-12; the acne-recurring and anti-recurrence composition used in application example 11 is the acne-recurring and anti-recurrence composition prepared in embodiment 1;

[0151] The preparation methods of the anti-acne lotions of the application examples, comparative application examples and blank application examples are as follows:

[0152] (1) Component A and water are mixed and stirred, heated to 80° C., homogenized at a speed of 1200 rpm for 5 minutes, and kept warm for later use to obtain prefabricated component A;

[0153] (2) Mixing component B, heating to 80° C., homogenizing at 1200 rpm for 5 min, and keeping warm for later use to obtain prefabricated component B;

[0154] (3) mixing the C components and heating them to 60° C. to melt them to obtain a prefabricated C component;

[0155] (4) The preformed component A is heated to 80° C., and the preformed component B is added at a speed of 300 rpm, and stirred and mixed. Then, the temperature is lowered to 60° C., and the preformed component C is added at a speed of 300 rpm, and stirred and mixed. Then, the temperature is lowered to below 45° C., and the acne-removing and anti-recurrence composition and essence are added, and stirring is continued for 5 minutes. Finally, arginine is added to adjust the pH to 5.0-6.5, and stirring can be stopped. The material is discharged to obtain an acne-removing lotion.

[0156] Table 2

[0157]

[0158]

[0159] Effect Example 1 Inflammatory factor IL-1β level test

[0160] This effect example explores the anti-inflammatory effect of the acne-recurrence prevention composition prepared in Examples 1-10 and Comparative Examples 1-12.

[0161] Experimental materials: The cell line used was mouse macrophage RAW264.7, purchased from the Cell Resource Center of the Institute of Basic Medicine, Chinese Academy of Medical Sciences, fetal bovine serum (FBS, Gibco), DMEM high glucose medium (DMEM, Gibco), dimethyl sulfoxide (DMSO, Sigma), phosphate buffered saline (PBS, Gibco), thiazolyl blue (MTT, Sigma), mouse tumor necrosis factor-α enzyme-linked immunosorbent assay kit (Mouse TNF-α ELISA kit, Boster), mouse interleukin-1β enzyme-linked immunosorbent assay kit (Mouse IL-1β ELISA kit, Boster). The experimental group settings are shown in Table 3. The specific operations are as follows:

[0162] (1) Inoculation: cells were inoculated into 24-well plates and incubated in a 37°C, 5% CO2 incubator for 18-24 h;

[0163] (2) Solution preparation: Prepare the test substance and positive control according to Table 3;

[0164] (3) Sampling: According to the experimental grouping and concentration settings in Table 3, after the cells are plated and grown in the 24-well plate for 18-24 hours, group sampling is performed, and 3 replicate wells are set for each treatment group. Cell culture medium is added to the blank control and negative control groups, and cell culture medium containing samples of corresponding concentrations is added to the sample group, and culture is continued in a 37°C, 5% CO2 incubator for 18-24 hours;

[0165] (4) LPS induction: After 18-24 h of culture, the culture medium in the plate was aspirated and the cells were gently washed once with PBS. Cell culture medium was added to the blank control group, and cell culture medium containing LPS was added to the negative control group, sample group, and positive control group. The cells were cultured in a 37°C, 5% CO2 incubator for 18-24 h and the supernatant was collected.

[0166] (5) Detection of inflammatory factor content: Take the cell supernatant from each well and detect the cell inflammatory factor content according to the ELISA kit operating instructions;

[0167] (6) Data processing: All data obtained in the experiment were processed and plotted using Excel software. SPSS17.0 was used for statistical analysis, and one-way analysis of variance (ANOVA) was used for inter-group comparison. When P < 0.05, the difference was considered significant. The results are shown in Table 4.

[0168] Table 3

[0169]

[0170] Table 4

[0171]

[0172]

[0173] Note: Compared with the blank control group, the significance is indicated by #, and P value < 0.0001 is indicated by ####. Compared with the negative control group, the significance is indicated by *, and P value < 0.05 is indicated by *, P value < 0.01 is indicated by **, P value < 0.0001 is indicated by ****, and P value > 0.05 is indicated by ns.

[0174] Interleukin-1β (IL-1β) plays an important role in immune regulation and inflammatory response, and is considered to be one of the main endogenous mediators of inflammatory response and fever response. IL-1β is a key inflammatory mechanism that drives the host's response to Pseudomonas acnes infection, aggravating skin acne. This experiment is based on the LPS-induced mouse macrophage (RAW264.7) inflammation model, and evaluates the ability of Examples 1-10 and Comparative Examples 1-12 to reduce the expression and secretion of cellular inflammatory factors, and then predicts its ability to inhibit further inflammatory response, in order to prove the effect of the acne-removing and recurrence-preventing composition in removing acne.

[0175] From the test results in Table 4, it can be seen that after applying the acne-removing and recurrence-preventing compositions of Examples 1-10 provided by the present invention, the average concentration of cellular inflammatory factors is 31.47-38.71 pg / mL, indicating that the acne-recurrence-preventing and recurrence-preventing compositions of the present invention have an inhibitory effect on the overexpression of IL-1β induced by lipopolysaccharide LPS, and the inhibitory effects are significant, among which the inhibitory effect of Example 1 is the best.

[0176] By comparing Example 1 and Comparative Examples 1-12, it can be seen that the lack of any one of epigallocatechin gallate glucoside, brazilian hematoxylin, roselle flower extract, jujube bark extract, linseed oil unsaponifiable matter, and guaiac extract or the use of other functional analogs for replacement, the average concentration of cellular inflammatory factors is greater than 40 pg / mL, indicating that the lack of any one of epigallocatechin gallate glucoside, brazilian hematoxylin, roselle flower extract, jujube bark extract, linseed oil unsaponifiable matter, and guaiac extract or the use of other functional analogs for replacement will lead to a decrease in the anti-inflammatory effect of the acne-removing and recurrence-preventing composition.

[0177] Effect Example 2: Inhibition Test of Propionibacterium acnes

[0178] This effect example explores the inhibitory effect of the acne-recurrence prevention composition prepared in Examples 1-10 and Comparative Examples 1-12 on Propionibacterium acnes.

[0179] The 96-well plate crystal violet staining method was used, and the sample was added to a certain concentration of bacterial solution so that the final dosing mass concentration was 200 μg / mL. It was cultured under anaerobic conditions at 37°C for 6 days, the upper planktonic cells were discarded, washed with sterile water, and then formaldehyde was added to fix for 10 minutes. After removal, it was air-dried for 5 minutes, and the biofilm was stained with 0.1% crystal violet for 20 minutes. After removing the dye, 955 ethanol was added for decolorization for 15 minutes, 100 μL of the decolorizing solution was taken in a blank well plate, and the absorbance was measured at a wavelength of 570 nm using an enzyme reader. The biofilm of the control group without adding the composition was 100%, and the percentage of biofilm formation in each experimental group was calculated. The results are shown in Table 5.

[0180] Table 5

[0181]

[0182]

[0183] Note: Compared with the blank control group, the significance is indicated by #, P value < 0.05 is indicated by *, P value < 0.01 is indicated by **, P value < 0.0001 is indicated by ****, and P value > 0.05 is indicated by ns.

[0184] The total detection rate of Propionibacterium acnes in acne facial lesions is higher than that in normal facial skin. Propionibacterium acnes is the main bacteria isolated from facial lesions in acne. Inhibiting the activity of Propionibacterium acnes can effectively improve the severity of acne. This experiment tests the inhibition rate of Propionibacterium acnes biofilm to evaluate the antibacterial ability of the acne-removing and recurrence-preventing composition.

[0185] From the experimental results in Table 5, it can be seen that the biofilm formation rate of the acne-removing and recurrence-preventing compositions of Examples 1-10 of the present invention is 50.13-63.57%, indicating that the acne-recurrence-preventing and recurrence-preventing compositions of the present invention have a significant inhibitory effect on Propionibacterium acnes.

[0186] By comparing Example 1 and Comparative Examples 1-12, it can be seen that the lack of any one of epigallocatechin gallate glucoside, brazilian hematoxylin, roselle flower extract, jujube bark extract, linseed oil unsaponifiable matter, and guaiac extract or the use of other functional analogs for replacement, the biofilm formation rate is greater than 88%, indicating that the lack of any one of epigallocatechin gallate glucoside, brazilian hematoxylin, roselle flower extract, jujube bark extract, linseed oil unsaponifiable matter, and guaiac extract or the use of other functional analogs for replacement will result in a significant decrease in the inhibitory effect of the acne-removing and recurrence-preventing composition on Propionibacterium acnes.

[0187] Effect Example 3 Human Efficacy Test

[0188] This effect example tests the improvement effects of Application Examples 1-11, Comparative Application Examples 1-12 and Blank Application Example on human acne, skin moisture content, redness and oil.

[0189] The specific test method is as follows:

[0190] According to the "Technical Specifications for Safety of Cosmetics" (2015), 184 volunteers aged 45-60 with sensitive skin (lactic acid stinging score>3) were selected and randomly divided into 23 groups, 8 people in each group, and the volunteers had to have at least 2-3 obvious acne. Under normal circumstances, volunteers continued to use the product on their entire face for 7 days (D7), and then stopped using it for 7 days (T7); every morning and evening, after cleansing and moisturizing, volunteers applied an appropriate amount of lotion to their face and massaged for absorption. The acne area can be overlapped and applied to the entire face once in the morning and evening, and revisited every day. On the day of the volunteer's visit, the test area washed its face with clean water without applying any product, and sat quietly in an air-conditioned room with a temperature of 21±1℃ and a humidity of 50±10% for 20 minutes. The improvement of facial acne indicators was quantified and photographed using instruments, including Visia 7 (IPP) test of facial red area a*, acne count (classification count: comedones, papules, respectively using VISIA and doctor evaluation), Tewameter TMHex test of transepidermal water loss TEWL, and Sebumeter SM 815 test of oil content. The improvement rate before and after use = (X mean value before use - X mean value after use) / X mean value before use × 100%; the calculation results are shown in Table 6.

[0191] Table 6

[0192]

[0193]

[0194] Note: * indicates that the difference is statistically significant compared with the blank application example (P < 0.05).

[0195] From the experimental results in Table 6, it can be seen that by applying the anti-acne emulsions of Examples 1-11 of the present invention, the D7 improvement rate of facial acne in acne patients with sensitive skin is 38.1-43.8%, and the T7 improvement rate is 17.2-23.5%; the D7 improvement rate of papules is 28.5-34.6%, and the T7 improvement rate is 15.1-19.8%; the D7 improvement rate of TEWL is 15.3-19.4%, and the T7 improvement rate is 7.6-11.3%; the D7 improvement rate of facial red area a* is 24.0-30.8%, and the T7 improvement rate is 15.2-19.5%; the D7 improvement rate of oil content is 22.0-25.8%, and the T7 improvement rate is 14.3-18.3%; It shows that the application of the anti-acne recurrence prevention composition of the present invention can effectively improve acne, papules, a*, TEWL and oil content of sensitive skin; that is, the anti-acne recurrence prevention composition of the present invention has good acne removal, repair and oil control effects.

[0196] From Application Example 1 and Comparative Application Examples 1-12, it can be seen that when any one of epigallocatechin gallate glucoside, brazilian hematoxylin, roselle flower extract, jujube bark extract, linseed oil unsaponifiable matter, and guaiac extract is lacking or replaced with other functional analogs, the D7 improvement rate of acne is less than 19%, and the T7 improvement rate is less than 4%; the D7 improvement rate of papules is less than 13%, and the T7 improvement rate is less than 5%; the D7 improvement rate of TEWL is less than 6.5%, and the T7 improvement rate is less than 1%; the D7 improvement rate of facial red area a* is less than 10%. The improvement rate of D7 in terms of oil content is less than 12%, and the improvement rate of T7 is less than 3%; the improvement rate of D7 in terms of oil content is less than 10%, and the improvement rate of T7 is less than 3%; this indicates that the lack of any one of epigallocatechin gallate glucoside, brazilian hematoxylin, roselle flower extract, jujube bark extract, linseed oil unsaponifiable matter, and guaiac extract, or the use of other functional analogues for replacement, will result in the acne-removing and anti-recurrence composition having no significant improvement on skin acne, papules, a*, TEWL, and oil content, that is, the acne-removing, repairing, and oil-controlling effects of the acne-removing and anti-recurrence composition are significantly reduced.

[0197] Finally, it should be noted that the above embodiments are used to illustrate the technical solution of the present invention rather than to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the essence and scope of the technical solution of the present invention.

Claims

1. A composition for removing acne and preventing recurrence, characterized in that: The acne-removing and recurrence-preventing composition comprises the following components in parts by weight: 0.01-3 parts of epigallocatechin gallate glucoside, 0.001-0.3 parts of brazilian hematoxylin, 1-15 parts of roselle flower extract, 0.1-1 parts of jujube bark extract, 0.01-3 parts of linseed oil unsaponifiable matter, and 1-15 parts of guaiac extract.

2. The acne-removing and recurrence-preventing composition according to claim 1, characterized in that: The acne-removing and recurrence-preventing composition comprises the following components in parts by weight: 0.05-1 part of epigallocatechin gallate glucoside, 0.005-0.1 part of brazilian hematoxylin, 3-10 parts of roselle flower extract, 0.1-0.5 part of jujube bark extract, 0.05-1 part of linseed oil unsaponifiable matter, and 1-8 parts of guaiac extract.

3. The acne-removing and recurrence-preventing composition according to claim 1, characterized in that: The acne-removing and recurrence-preventing composition comprises the following components in parts by weight: 0.5-1 part of epigallocatechin gallate glucoside, 0.01-0.1 part of brazilian hematoxylin, 3-8 parts of roselle flower extract, 0.15-0.5 part of jujube bark extract, 0.08-0.5 part of linseed oil unsaponifiable matter, and 2-5 parts of guaiac wood extract.

4. The acne-removing and recurrence-preventing composition according to any one of claims 1 to 3, characterized in that: The preparation method of the roselle flower extract comprises: adding roselle flowers to an acidified ethanol solution for ultrasonic extraction, performing solid-liquid separation after the extraction, and drying the obtained filtrate to obtain the roselle flower extract; And / or, the preparation method of the Zizyphus joazeiro bark extract is: adding Zizyphus joazeiro bark into an ethanol aqueous solution for extraction, and after the extraction is completed, performing solid-liquid separation, and drying the obtained filtrate to obtain the Zizyphus joazeiro bark extract.

5. The acne-removing and recurrence-preventing composition according to claim 4, characterized in that: In the preparation method of the roselle flower extract, the water content of the roselle flower is 4-6%; and / or, the average particle size of the roselle flower is ≤150 μm; and / or, the solid-to-liquid ratio of the roselle flower to the acidified ethanol solution is 1 g: 30-40 mL; And / or, the frequency of the ultrasonic extraction is 120-160 Hz; And / or, the ultrasonic extraction time is 25-35min; And / or, the temperature of the ultrasonic extraction is 45-55°C; And / or, the pH of the acidified ethanol solution is 2.5-3.

5.

6. The acne-removing and recurrence-preventing composition according to claim 4, characterized in that: In the preparation method of the jujube bark extract, the solid-liquid ratio of the jujube bark to the ethanol aqueous solution is 1g:10-20mL; And / or, the volume percentage of ethanol in the ethanol aqueous solution is 65-75%; And / or, the extraction method is one of leaching, reflux extraction and ultrasonic extraction.

7. Use of the acne-removing and recurrence-preventing composition according to any one of claims 1 to 6 in the preparation of cosmetics.

8. A cosmetic, characterized in that: The cosmetic comprises the acne-eliminating and recurrence-preventing composition according to any one of claims 1 to 6, and the content of the acne-eliminating and recurrence-preventing composition in the cosmetic is 0.1-3 wt %.

9. The cosmetic according to claim 8, characterized in that The cosmetic is an anti-acne lotion, and the anti-acne lotion comprises the following components in percentage by mass: 0.1-3% of an anti-acne recurrence prevention composition, 0.05-5% of a thickener, 3-20% of a moisturizer, 0.5-10% of an emulsifier, 0.2-5% of a preservative, 0.05-0.1% of a pH adjuster, and the remainder being water.

10. The cosmetic according to claim 9, characterized in that The thickener comprises at least one of xanthan gum, carbomer, ammonium acrylamide dimethyl taurate / VP copolymer, and cellulose; And / or, the moisturizing agent includes at least one of glycerin, butylene glycol, and sodium hyaluronate; And / or, the emulsifier includes at least one of coconut oil alcohol-caprylate / caprate, polydimethylsiloxane, hydrogenated palm kernel oil, cetearyl alcohol, polyglyceryl-6 distearate, and polymethyl silsesquioxane; And / or, the preservative includes at least one of 1,3-propylene glycol, 1,2-hexanediol, and p-hydroxyacetophenone; And / or, the pH adjuster includes at least one of arginine and disodium ethylenediaminetetraacetate.

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