Buccal product and preparation method thereof

Abstract

The invention discloses a buccal product and a preparation method thereof, and belongs to the technical field of smokeless tobacco products. The preparation method of the buccal product comprises the following steps: raw materials are mixed to obtain a mixture, and the raw materials comprise the following components in parts by mass: 40-90 parts of a base material, 0.5-10 parts of a nicotine raw material, 1-3 parts of a sweetening agent, 0.5-2 parts of edible essence and 3-7 parts of an adhesive; the mixture is dissolved in a solvent to obtain a mixed solution, and the mass part of the solvent is 1-40; coating the mixed solution to obtain coated particles; and drying the coated particles to obtain the buccal product. According to the preparation method provided by the invention, based on selection of the raw material components and control of the proportional relation among the raw material components, a coating treatment process is adopted, so that the nicotine raw material is attached to the base material, the base material is coated with the adhesive, and due to the fact that the dissolving speed of the adhesive in the oral cavity and the acting force of the base material on the nicotine are relatively stable, the oral cavity is not damaged. Therefore, the release rate of nicotine can be stably controlled.

Description

Technical Field

[0001] The present application relates to the technical field of smokeless tobacco products, and in particular to an oral product and a preparation method thereof. Background Art

[0002] Oral products are smokeless products containing nicotine. Oral products usually do not need to be burned. Instead, they are placed in the mouth so that nicotine is absorbed by the oral mucosa, providing consumers with a certain nicotine satisfaction through oral administration. Existing oral products have different dissolution rates in the mouth, resulting in unstable nicotine release rates, which affects the user experience. Summary of the invention

[0003] The present application provides an oral product and a preparation method thereof, which can solve the technical problem of unstable nicotine release rate of the oral product.

[0004] In order to solve the above technical problems, the present application provides, on the one hand, a method for preparing an oral product, comprising: mixing raw materials to obtain a mixture, wherein the raw materials include the following components in parts by mass: 40-90 parts of a base material, 0.5-10 parts of a nicotine raw material, 1-3 parts of a sweetener, 0.5-2 parts of an edible flavor, and 3-7 parts of an adhesive; dissolving the mixture in a solvent to obtain a mixed liquid, wherein the solvent is 1-40 parts in parts by mass; coating the mixed liquid to obtain coated particles, so that the nicotine raw material is attached to the base material, and the adhesive coats the base material; and drying the coated particles to obtain the oral product.

[0005] In one embodiment, the substrate is at least one of porous gum arabic, porous maltodextrin, porous starch, and porous carboxymethyl cellulose.

[0006] In one embodiment, the time when 80% of the nicotine in the oral product is released is taken as the peak time, and the peak time of the oral product prepared based on the substrate is 4-32 minutes.

[0007] In one embodiment, before mixing the raw materials to obtain the mixture, the base material is screened to control the particle size of the base material between 100-300 μm; and drying the coated particles to obtain the oral preparation includes screening the dried coated particles to control the particle size of the oral preparation between 120-320 μm.

[0008] In one embodiment, the pore size of the substrate is 5-30 μm.

[0009] In one embodiment, the nicotine raw material includes at least one of pure nicotine, nicotine salt, natural nicotine, and hexamethyl nicotine; the sweetener includes at least one of xylitol, sorbitol, mannitol, iglete, lactitol, maltitol, isomalt, hydrogenated starch hydrolysate, erythritol, maltotriitol, aspartame, acesulfame potassium, saccharin sodium, sucralose, neotame, cyclamate, alitame, steviol glycosides, arabitol, and monk fruit sweetener; the edible flavor includes at least one of mint flavor, watermelon flavor, apple flavor, lemon flavor, vanilla flavor, and citrus flavor; the binder includes at least one of sodium carboxymethyl cellulose, hydroxypropyl methylcellulose, microcrystalline cellulose, and low-substituted hydroxypropyl cellulose; and the solvent includes water.

[0010] In one embodiment, the raw materials further include the following components, measured by weight: 0.1-0.5 parts of preservatives and 0.3-1 parts of acid-base regulators; the preservatives include at least one of benzalkonium chloride, sodium chloride, sorbic acid, benzoic acid and its sodium salt, parabens and its sodium salt, disodium ethylenediaminetetraacetic acid, and sodium acetate; the acid-base regulator includes at least one of sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, phosphates, hydroxides, and tris(hydroxymethyl)aminomethane.

[0011] In one embodiment, the raw materials are mixed to obtain a mixture, including a rotation speed of the mixed raw materials of 300-400rpm and a mixing time of 15-20min; the mixture is dissolved in a solvent to obtain a mixed liquid, including a dissolution temperature of 20-30°C, a stirring speed of 450-550rpm, and a dissolution time of 1.0-2.0h; the mixed liquid is coated to obtain coated particles, including a coating treatment temperature of 40-50°C, a spray rate of 1.0-2.0mL / min, and a coating treatment time of 15-25min.

[0012] In one embodiment, drying the coated particles to obtain the oral product includes drying the coated particles in a microwave dryer, wherein the microwave power is 1 kg of raw material / 3-6 kW and the drying time is 10-20 min.

[0013] On the other hand, the present application provides an oral product prepared by the preparation method as described above.

[0014] The preparation method provided in the present application is based on the selection of raw material components and the control of the proportional relationship between the raw material components, and adopts a coating treatment process, so that the nicotine raw material is attached to the substrate, and the adhesive coats the substrate. Since the dissolution rate of the adhesive in the oral cavity and the force of the substrate on nicotine are relatively stable, the release rate of nicotine can be stably controlled. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings required for use in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0016] Figure 1 It is a schematic diagram of a process of an embodiment of a preparation method provided by the present application;

[0017] Figure 2 is a schematic flow chart of another embodiment of the preparation method provided by the present application;

[0018] Figure 3 is a comparison chart of the dissolution test results of Example A and Comparative Example a;

[0019] Figure 4 is a comparison chart of the dissolution test results of Example A and Comparative Example B;

[0020] Figure 5 is a comparison chart of the dissolution test results of Example A and Comparative Example C;

[0021] Figure 6 is a comparison chart of the dissolution test results of Example A and Comparative Example d;

[0022] Figure 7 is a comparison chart of the dissolution test results of Example A and Comparative Example e;

[0023] Figure 8 It is a comparison chart of the dissolution test results of Examples AD. DETAILED DESCRIPTION

[0024] The present application is further described in detail below in conjunction with the accompanying drawings and examples. It is particularly noted that the following examples are only used to illustrate the present application, but are not intended to limit the scope of the present application. Similarly, the following examples are only some embodiments of the present application rather than all embodiments, and all other embodiments obtained by ordinary technicians in the field without making creative work are within the scope of protection of the present application.

[0025] In the description of the present application, the meaning of "multiple" is at least two, such as two, three, etc., unless otherwise clearly and specifically limited. The terms "first", "second", and "third" in the embodiments of the present application are only used for descriptive purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, the features defined as "first", "second", and "third" can expressly or implicitly include at least one of the features. In the embodiments of the present application, all directional indications (such as up, down, left, right, front, back...) are only used to explain the relative position relationship, movement, etc. between the components under a certain specific posture (as shown in the accompanying drawings). If the specific posture changes, the directional indication also changes accordingly. The terms "including" and "having" in the embodiments of the present application and any of their variations are intended to cover non-exclusive inclusions. For example, a process, method, system, product, or device that includes a series of steps or units is not limited to the listed steps or units, but optionally also includes steps or units that are not listed, or optionally also includes other steps or components inherent to these processes, methods, products, or devices.

[0026] Reference to "embodiments" herein means that a particular feature, structure, or characteristic described in conjunction with the embodiments may be included in at least one embodiment of the present application. The appearance of the phrase in various locations in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0027] The present application provides a method for preparing an oral product. Figure 1 The preparation method may include steps S10-S40:

[0028] S10, mixing the raw materials to obtain a mixture. Thoroughly mixing the raw materials can make the distribution of the ingredients in the prepared oral product more uniform, thereby improving the taste of the oral product. The base material can be used as a carrier of nicotine raw materials. As the main active ingredient, the nicotine raw material can release nicotine to be absorbed by the oral mucosa. Sweeteners can increase the diversity of the taste of oral products, and edible flavors are used to adjust the taste. The adhesive stabilizes the structure of the oral product, thereby improving the taste consistency of the oral product.

[0029] The raw materials include the following components by weight: 40-90 parts of substrate, 0.5-10 parts of nicotine raw material, 1-3 parts of sweetener, 0.5-2 parts of edible flavor, and 3-7 parts of adhesive. The selection of raw material components and the control of the proportion relationship between the raw material components are conducive to coating the nicotine raw material on the substrate in the subsequent coating process.

[0030] In one embodiment, the mass fraction of the substrate may be 40 parts, 45 parts, 50 parts, 55 parts, 60 parts, 65 parts, 70 parts, 75 parts, 80 parts, 85 parts or 90 parts, which is not specifically limited herein.

[0031] In one embodiment, the mass proportion of the nicotine raw material may be 0.5, 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10.

[0032] In one embodiment, the mass proportion of the sweetener may be 1 part, 1.5 parts, 2 parts, 2.5 parts or 3 parts.

[0033] In one embodiment, the mass fraction of the edible flavor can be 0.5 parts, 0.8 parts, 1 parts, 1.2 parts, 1.5 parts, 1.8 parts or 2 parts.

[0034] In one embodiment, the mass fraction of the adhesive may be 3 parts, 4 parts, 5 parts, 6 parts or 7 parts.

[0035] S20, dissolving the mixture in a solvent to obtain a mixed solution. Dissolving the mixture in a solvent can fully dissolve the adhesive, thereby enhancing the structural stability of the oral product.

[0036] The solvent is present in an amount of 1-40 parts by weight. In one embodiment, the solvent may be present in an amount of 1, 5, 10, 15, 20, 25, 30, 35 or 40 parts by weight.

[0037] S30, coating the mixed solution to obtain coated particles, so that the nicotine raw material is attached to the substrate, and the adhesive coats the substrate.

[0038] Through coating treatment, the substrate serves as a carrier of nicotine raw materials, and the nicotine raw materials can be adsorbed or embedded in the substrate, so that the nicotine raw materials are attached to the substrate, and the force of the substrate on nicotine is relatively stable.

[0039] S40, drying the coated granules to obtain an oral preparation.

[0040] The preparation method provided in the present application is based on the selection of raw material components and the control of the proportional relationship between the raw material components, and adopts a coating treatment process, so that the nicotine raw material is attached to the substrate, and the adhesive coats the substrate. Since the dissolution rate of the adhesive in the oral cavity and the force of the substrate on nicotine are relatively stable, the release rate of nicotine can be stably controlled.

[0041] In one embodiment, the substrate is at least one of porous gum arabic, porous maltodextrin, porous starch, and porous carboxymethyl cellulose. Experiments show that porous gum arabic, porous maltodextrin, porous starch, and porous carboxymethyl cellulose have different effects on nicotine, so the above substrates can be used to prepare products with different nicotine release rates to meet the personalized needs of users.

[0042] As the adhesive dissolves in the oral cavity, the nicotine in the nicotine raw material attached to the substrate is continuously released, and the time when 80% of the nicotine in the oral product is released can be taken as the peak time. In one embodiment, the peak time of the oral product prepared based on the substrate is 4-32min. Specifically, when the substrate is porous gum arabic, the peak time of the oral product is 4-6min, the release rate of nicotine is fast, and a fast-release product can be prepared; when the substrate is porous maltodextrin, the peak time of the oral product is 8-12min, the release rate of nicotine is fast, and a faster release product can be prepared; when the substrate is porous starch, the peak time of the oral product is 18-22min, the release rate of nicotine is slow, and a slower release product can be prepared; when the substrate is porous carboxymethyl cellulose, the peak time of the oral product is 28-32min, the release rate of nicotine is slow, and a slow release product can be prepared. It can be seen that the products prepared using the above-mentioned substrates have different peak times, which can meet the personalized needs of users.

[0043] In one embodiment, the nicotine raw material includes at least one of pure nicotine, nicotine salt, natural nicotine, and hexamethyl nicotine.

[0044] In one embodiment, the sweetener includes at least one of xylitol, sorbitol, mannitol, igltol, lactitol, maltitol, isomalt, hydrogenated starch hydrolysate, erythritol, maltotriitol, aspartame, acesulfame potassium, saccharin sodium, sucralose, neotame, cyclamate, alitame, steviol glycosides, arabitol, and monk fruit sweetener.

[0045] In one embodiment, the edible flavor includes at least one of mint flavor, watermelon flavor, apple flavor, lemon flavor, vanilla flavor, and citrus flavor.

[0046] In one embodiment, the binder includes at least one of sodium carboxymethylcellulose, hydroxypropyl methylcellulose, microcrystalline cellulose, and low-substituted hydroxypropyl cellulose.

[0047] The solvent may include ethanol. In one embodiment, the solvent includes water. Compared with ethanol, the oral product prepared with solvent water has a milder mouthfeel and can reduce irritation to the oral cavity.

[0048] In one embodiment, the raw materials further include the following components, measured by weight: 0.1-0.5 parts of preservatives and 0.3-1 parts of acid-base regulators. Preservatives can prevent the oral product from deteriorating, thereby ensuring the long-term safety of the oral product. Acid-base regulators are used to adjust the pH value of the oral product to optimize the stability and release efficiency of nicotine.

[0049] In one embodiment, the preservative includes at least one of benzalkonium chloride, sodium chloride, sorbic acid, benzoic acid and its sodium salt, parabens and its sodium salt, disodium edetate, and sodium acetate.

[0050] In one embodiment, the acid-base regulator includes at least one of sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, phosphate, hydroxide, and tris(hydroxymethyl)aminomethane.

[0051] See also Figure 2 In one embodiment, step S05 is further included before step S10:

[0052] S05, the substrate is screened to control the particle size of the substrate to be between 100-300 μm. The substrate can be screened using a raw material screening machine. Screening the substrate can ensure the consistency of the particle size of the substrate, thereby making the effect of the substrate on nicotine relatively stable, and the peak time of the product is in line with expectations.

[0053] Specifically, when the substrate is porous gum arabic or porous maltodextrin, the particle size of the substrate is controlled between 100-300 μm; when the substrate is porous starch, the particle size of the substrate is controlled between 150-250 μm; when the substrate is porous carboxymethyl cellulose, the particle size of the substrate is controlled between 200-300 μm.

[0054] In one embodiment, the pore size of the substrate is 5-30 μm. By controlling the pore size of the substrate, the consistency of the pore size of the substrate can be ensured, thereby making the effect of the substrate on nicotine relatively stable, and the peak time of the product meets expectations.

[0055] Specifically, when the substrate is porous gum arabic, the pore size of the substrate is controlled between 5-15 μm; when the substrate is porous maltodextrin, the pore size of the substrate is controlled between 5-10 μm; when the substrate is porous starch, the pore size of the substrate is controlled between 10-15 μm; when the substrate is porous carboxymethyl cellulose, the pore size of the substrate is controlled between 20-30 μm.

[0056] In one embodiment, the raw materials are mixed with a high-speed mixer to obtain a mixture, wherein the rotation speed of the mixed raw materials is 300-400 rpm and the mixing time is 15-20 minutes. By controlling the rotation speed and mixing time of the mixed raw materials, the raw materials can be fully mixed, so that the components in the prepared oral product are distributed more evenly, thereby improving the taste of the oral product.

[0057] In one embodiment, a mixed liquid is prepared by a double-shaft mixer, and the mixed material is dissolved in a solvent to obtain a mixed liquid, wherein the dissolution temperature is 20-30° C., the stirring speed is 450-550 rpm, and the dissolution time is 1.0-2.0 h. Based on the control of the dissolution temperature, stirring speed, and dissolution time of the mixed liquid, the adhesive can be fully dissolved, so that the adhesive can better coat the substrate, thereby enhancing the structural stability of the oral product.

[0058] In one embodiment, a fluidized bed coating machine is used to prepare coated particles, and the mixed solution is subjected to coating treatment to obtain coated particles, including a coating treatment temperature of 40-50°C, a spray rate of 1.0-2.0 mL / min, and a coating treatment time of 15-25 min. By controlling the treatment temperature, spray rate, and treatment time in the coating treatment process, the nicotine raw material can be attached to the substrate, and the adhesive can coat the substrate, thereby effectively regulating the release rate of nicotine and stably controlling the release rate of nicotine.

[0059] In one embodiment, drying the coated particles to obtain the oral product includes drying the coated particles using a microwave dryer, wherein the microwave power is 1kg of raw material / 3-6kW, and the drying time is 10-20min. The microwave dryer can ensure accurate moisture control of the product during the production process, thereby extending the shelf life of the product.

[0060] In one embodiment, drying the coated particles to obtain the oral product includes sieving the dried coated particles to control the particle size of the oral product to be between 120-320 μm. By sieving the oral product to remove unqualified particles, the consistency of the oral product can be ensured, thereby ensuring that the peak time of the product meets expectations.

[0061] Specifically, when the substrate is porous gum arabic or porous maltodextrin, the mesh number of the sieve is 70-100 mesh, and a finer sieve is used. The particle size of the oral product is controlled between 100-300 μm, so that the particle size of the oral product is relatively small, and a fast or relatively fast release product can be prepared; when the substrate is porous starch, the mesh number of the sieve is 60-80 mesh, and a medium sieve is used. The particle size of the oral product is controlled between 150-250 μm, so that the particle size of the oral product is moderate, and the prepared product can balance the release speed and durability; when the substrate is porous carboxymethyl cellulose, the mesh number of the sieve is 50-70 mesh, and a coarser sieve is used. The particle size of the oral product is controlled between 200-300 μm, so that the particle size of the oral product is larger, and a product with a long release time can be prepared.

[0062] The present application provides an oral product, which is prepared by the preparation method described above. The oral product provided by the present application is based on the selection of raw material components and the control of the ratio between the raw material components, and adopts a coating process, so that the nicotine raw material is attached to the substrate, and the adhesive coats the substrate. Since the dissolution rate of the adhesive in the oral cavity and the force of the substrate on nicotine are relatively stable, the release rate of nicotine can be stably controlled.

[0063] The present application is described below through specific examples, in which oral products are prepared according to the above preparation method. The following examples are only partial examples of the present application and are not intended to limit the present application.

[0064] Example A, the formula is shown in Table 1.

[0065] Table 1 Example A formula

[0066]

[0067]

[0068] Example B, the formula is shown in Table 2.

[0069] Table 2 Example B formula

[0070]

[0071] Example C, the formula is shown in Table 3.

[0072] Table 3 Example C formula

[0073]

[0074] Example D, the formula is shown in Table 4.

[0075] Table 4 Example D formula

[0076]

[0077]

[0078] A comparative example was set according to Example A, and the formula of the comparative example is shown in Table 5.

[0079] Table 5 Comparative Example and Example A

[0080]

[0081] The oral preparations prepared in the examples and comparative examples were subjected to dissolution tests.

[0082] Equipment: Dissolution apparatus-paddle method;

[0083] Sample: 1g of each of the powders of Examples A, B, C, D and Comparative Examples a, b, c, d, e;

[0084] Dissolution medium: artificial saliva-pH 6.8;

[0085] Sampling points: 0.5min, 1min, 2min, 5min, 10min, 15min, 20min, 30min, 40min, 60min;

[0086] Test conditions: heating temperature 37°C, speed 100r / min;

[0087] Analysis method: Nicotine content was determined using high performance liquid chromatography.

[0088] The test results are shown in Table 6, Table 7 and Figure 3-Figure 8 shown.

[0089] Table 6 Example test results

[0090] Time(min) A(mg) B(mg) C(mg) D(mg) 0.5 5.56 2.95 1.47 0.59 1 10.23 5.77 2.91 1.18 2 18.12 11.09 5.74 2.34 5 27.07 22.12 13.46 5.78 10 29.18 27.23 24.03 11.16 15 29.68 28.86 27.71 16.13 20 29.85 29.56 29.09 20.57 30 29.96 29.91 29.77 27.23 40 29.98 29.26 29.73 29.18 60 29.18 29.96 29.93 29.91

[0091] Table 7 Comparative test results

[0092]

[0093]

[0094] from Figure 3-Figure 8It can be seen that in comparative examples ad, due to the mismatch in the ratio between the raw material components, the nicotine raw material is difficult to adhere to the substrate, or the adhesive and the substrate are not coated, the dissolution curve is bent, and the release rate of nicotine is unstable; in comparative example e, due to the lack of a coating process, the adhesive is difficult to coat the substrate, the dissolution curve is bent, and the release rate of nicotine is unstable; relative to comparative example ae, the dissolution curve of Example AD is relatively smooth, that is, the release rate of nicotine in Example AD is more stable. The test results show that the preparation method provided in the present application is based on the selection of raw material components and the control of the proportional relationship between the raw material components, and adopts a coating process, so that the nicotine raw material is attached to the substrate, and the adhesive coats the substrate, which can stably control the release rate of nicotine.

[0095] In addition, from Figure 8 It can be seen that in Examples AD, the substrates are porous gum arabic, porous maltodextrin, porous starch and porous carboxymethyl cellulose, respectively, and the time when 80% of the nicotine in the oral preparation is released is taken as the peak time. The peak time of the oral preparation is 4-32 minutes. Specifically, when the substrate is porous gum arabic, the peak time of the oral preparation is 4-6 minutes, the release rate of nicotine is fast, and the porous gum arabic substrate can be used for fast-release products; when the substrate is porous maltodextrin, the peak time of the oral preparation is 8-12 minutes, the release rate of nicotine is faster, and the porous maltodextrin substrate can be used for fast-release products; when the substrate is porous starch, the peak time of the oral preparation is 18-22 minutes, the release rate of nicotine is slower, and the porous starch substrate can be used for slower-release products; when the substrate is porous carboxymethyl cellulose, the peak time of the oral preparation is 28-32 minutes, the release rate of nicotine is slow, and the porous carboxymethyl cellulose substrate can be used for slow-release products. The products prepared using the above substrates have different peak times, which can meet the personalized needs of users.

[0096] The above descriptions are only some embodiments of the present application, and do not limit the protection scope of the present application. Any equivalent device or equivalent process transformation made using the contents of the present application specification and drawings, or directly or indirectly used in other related technical fields, are also included in the patent protection scope of the present application.

Claims

1. A method for preparing an oral product, characterized in that: include: The raw materials are mixed to obtain a mixture, wherein the raw materials include the following components by weight: 40-90 parts of a base material, 0.5-10 parts of a nicotine raw material, 1-3 parts of a sweetener, 0.5-2 parts of an edible flavor, and 3-7 parts of a binder; Dissolving the mixed material in a solvent to obtain a mixed solution, wherein the solvent is 1-40 parts by mass; Performing coating treatment on the mixed solution to obtain coated particles, so that the nicotine raw material is attached to the substrate and the adhesive covers the substrate; The coated granules are dried to obtain the oral preparation.

2. The method for preparing the oral product according to claim 1, characterized in that: The substrate is at least one of porous gum arabic, porous maltodextrin, porous starch and porous carboxymethyl cellulose.

3. The method for preparing the oral product according to claim 2, characterized in that: The time when 80% of the nicotine in the oral product is released is taken as the peak time. The peak time of the oral product prepared based on the substrate is 4-32 minutes.

4. The method for preparing the oral product according to claim 2, characterized in that: Before mixing the raw materials to obtain the mixed material, the method further includes screening the substrate to control the particle size of the substrate to be between 100-300 μm; The step of drying the coated particles to obtain the oral product includes sieving the dried coated particles to control the particle size of the oral product to be between 120-320 μm.

5. The method for preparing the oral product according to claim 2, characterized in that: The pore size of the substrate is 5-30 μm.

6. The method for preparing the oral product according to claim 1, characterized in that: The nicotine raw material includes at least one of pure nicotine, nicotine salt, natural nicotine, and hexamethyl nicotine; The sweetener includes at least one of xylitol, sorbitol, mannitol, igloo, lactitol, maltitol, isomalt, hydrogenated starch hydrolysate, erythritol, maltotriitol, aspartame, acesulfame potassium, saccharin sodium, sucralose, neotame, sodium cyclamate, alitame, steviol glycosides, arabitol, and monk fruit sweetener; The edible flavor includes at least one of mint flavor, watermelon flavor, apple flavor, lemon flavor, vanilla flavor, and citrus flavor; The binder comprises at least one of sodium carboxymethyl cellulose, hydroxypropyl methyl cellulose, microcrystalline cellulose, and low-substituted hydroxypropyl cellulose; The solvent includes water.

7. The method for preparing the oral product according to claim 1, characterized in that: The raw materials further include the following components in terms of weight: 0.1-0.5 parts of preservatives and 0.3-1 parts of acid-base regulators; The preservative includes at least one of benzalkonium chloride, sodium chloride, sorbic acid, benzoic acid and its sodium salt, parabens and its sodium salt, disodium ethylenediaminetetraacetate, and sodium acetate; The acid-base regulator includes at least one of sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, phosphate, hydroxide, and tris(hydroxymethyl)aminomethane.

8. The method for preparing the oral product according to any one of claims 1 to 7, characterized in that: The mixing of the raw materials to obtain the mixed material includes mixing the raw materials at a rotation speed of 300-400 rpm and a mixing time of 15-20 min; The step of dissolving the mixed material in a solvent to obtain a mixed solution includes: a dissolving temperature of 20-30° C., a stirring speed of 450-550 rpm, and a dissolving time of 1.0-2.0 h; The coating treatment of the mixed solution to obtain coated particles includes: a coating treatment temperature of 40-50° C., a spray rate of 1.0-2.0 mL / min, and a coating treatment time of 15-25 min.

9. The method for preparing the oral product according to any one of claims 1 to 7, characterized in that: The step of drying the coated particles to obtain the oral product comprises drying the coated particles in a microwave dryer, wherein the microwave power is 1 kg of raw material / 3-6 kW and the drying time is 10-20 min.

10. An oral product, characterized in that: The method is prepared by any one of claims 1 to 9.

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