Pre-pulse thulium laser lithotripsy system and method

Abstract

The pre-pulse thulium laser lithotripsy system comprises an interaction unit, a control unit, a thulium-doped fiber laser, a thulium-doped fiber amplifier, a laser fiber coupler and a lithotripsy fiber, wherein the interaction unit forwards a user instruction to the control unit; the control unit controls the thulium-doped fiber laser and the thulium-doped fiber amplifier according to a user instruction; the thulium-doped fiber laser outputs laser pulses to the thulium-doped fiber amplifier according to the control instruction; the thulium-doped optical fiber amplifier sets a laser amplification factor according to the control instruction and amplifies the laser pulse; the optical fiber coupler is used for coupling the amplified laser pulse; and the lithotripsy optical fiber acts the coupled laser pulse on the calculus or sticky tissue of the calculus patient. Through the combination of the thulium-doped fiber laser with the MOPA structure and the thulium-doped fiber amplifier, high-peak power nanosecond pulse can be realized, micro-explosion bubbles are instantly generated, the energy loss before laser acts on stones is reduced, the unit energy lithotripsy efficiency is improved, and the lithotripsy effect is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of laser lithotripsy, and in particular to a pre-pulse thulium laser lithotripsy system and method. Background Art

[0002] Stone disease is a common and frequent disease. When treating stone disease, the most convenient method is to crush and expel the stones in the patient's body. With the development of medical technology, minimally invasive lithotripsy has been more and more widely used. The main methods include laser lithotripsy, ultrasonic lithotripsy and pneumatic ballistic lithotripsy. In recent years, soft endoscope technology has developed rapidly. Most kidney stones can be crushed by laser through the ureter to avoid puncture injury, so laser lithotripsy has become more and more advantageous. When laser is used for kidney stone surgery, the ureter is slender and the perfusion fluid flow is small, so the heat removal capacity is weak. Generally, pulsed holmium or thulium laser lithotripsy produces large heat redundancy and is easy to burn the renal pelvis. At present, some double-pulse holmium lasers have improved the lithotripsy efficiency to a certain extent, but the longer pulse width cannot produce instantaneous vaporization, and most of the energy is lost, resulting in heat redundancy, which reduces the effect of the operation. Summary of the invention

[0003] In view of the above problems, the present invention is proposed to provide a pre-pulse thulium laser lithotripsy system and method that overcomes the above problems or at least partially solves the above problems.

[0004] In order to solve the above technical problems, the embodiments of the present application disclose the following technical solutions:

[0005] In a first aspect, an embodiment of the present invention discloses a pre-pulsed thulium laser lithotripsy system, comprising: an interaction unit, a control unit, a thulium-doped fiber laser, a thulium-doped fiber amplifier, a laser fiber coupler, and a lithotripsy fiber; wherein:

[0006] The output end of the interaction unit is connected to the input end of the control unit, and is used to receive user instructions and forward the user instructions to the control unit;

[0007] The input end of the control unit is connected to the interactive unit, and the output end is connected to the thulium-doped fiber laser and the thulium-doped fiber amplifier, for receiving the user instruction and controlling the thulium-doped fiber laser and the thulium-doped fiber amplifier according to the user instruction;

[0008] The input end of the thulium-doped fiber laser is connected to the control unit, and the output end is connected to the thulium-doped fiber amplifier, for receiving control instructions from the control unit, and outputting laser pulses to the thulium-doped fiber amplifier according to the control instructions;

[0009] The input end of the thulium-doped fiber amplifier is connected to the control unit and the thulium-doped fiber laser, and the output end is connected to the laser fiber coupler, and is used to receive control instructions from the control unit, set the laser amplification factor according to the control instructions, and receive laser pulses sent by the thulium-doped fiber laser, amplify the laser pulses, and send the amplified laser pulses to the fiber coupler;

[0010] The input end of the fiber coupler is connected to the thulium-doped fiber amplifier, and the output end is connected to the gravel fiber, and is used to receive the amplified laser pulse, couple the amplified laser pulse, and send the coupled laser pulse to the gravel fiber;

[0011] The input end of the lithotripsy optical fiber is connected to a fiber coupler for receiving coupled laser pulses and applying the coupled laser pulses to the stones or adhesive tissues of the stone patient.

[0012] The output end of the interactive unit is connected to the input of the control unit for receiving user instructions, wherein the user instructions at least include the start and end states of the thulium-doped fiber laser, the pulse frequencies of the thulium-doped fiber laser and the thulium-doped fiber amplifier, and the amplification factor of the thulium-doped fiber amplifier.

[0013] Furthermore, after receiving the user instruction, the control unit controls the thulium-doped fiber laser and the thulium-doped fiber amplifier by sending a TTL signal to the thulium-doped fiber laser and the thulium-doped fiber amplifier.

[0014] Furthermore, the thulium-doped fiber laser is a thulium-doped fiber laser with a MOPA structure, which outputs three pulses under the control of a TTL signal output by a control unit, wherein the first two pulses are lithotripsy pre-pulses with a pulse width of 100 nanoseconds, and the last pulse is a high-energy pulse with a pulse width of 100 microseconds.

[0015] Furthermore, the thulium-doped fiber amplifier receives the laser pulses sent by the thulium-doped fiber laser and amplifies the laser pulses. The specific method includes: the TTL signal for starting the thulium-doped fiber amplifier controls the TTL signal for outputting the pre-pulse of the laser to start hundreds of microseconds in advance, and the thulium-doped fiber is pumped in advance to form a large number of particle inversion accumulations, so that the first two pre-pulses of the thulium-doped fiber laser are amplified to a preset peak power.

[0016] Furthermore, the core diameter of the stone-breaking optical fiber is 200μm, the maximum aperture is 0.1, the first two pre-pulses of the thulium-doped fiber laser have a pulse width of 100ns, and the energy of a single pre-pulse is 10mJ. The first 10mJ of pre-pulse energy is instantly concentrated on tens of micrograms of water at the end of the optical fiber, causing the water to vaporize at a high speed into 1mm micro-explosion bubbles, and the adjacent second pre-pulse continues to advance forward 1mm, forming a 2mm gas channel at the front end of the optical fiber; at this time, the laser outputs a third high-energy pulse concentrated on the stone, forming an effective micro-explosion to crush the stone.

[0017] Furthermore, it also includes a semiconductor laser, a reflection device and a laser beam combining device; the input end of the semiconductor laser is connected to the control unit, and the output end is connected to the reflection device; the input end of the reflection device is connected to the semiconductor laser, and the output end is connected to the laser beam combining device; the input end of the laser beam combining device is connected to the thulium-doped fiber amplifier and the reflection device, and the output end is connected to the laser fiber coupler; the semiconductor laser receives instructions from the control unit to generate a 450nm blue laser, and the 450nm blue laser is combined with the thulium laser amplified by the thulium-doped fiber amplifier through the reflection device and the laser beam combining device, and is coupled into the lithotripsy fiber through the laser fiber coupler, and the stone adhesion tissue can be pre-bleached under the control of the control unit.

[0018] In a second aspect, an embodiment of the present invention discloses a pre-pulse thulium laser lithotripsy method, comprising:

[0019] The interaction unit receives the user instruction and forwards the user instruction to the control unit;

[0020] The control unit receives the user instruction and controls the thulium-doped fiber laser and the thulium-doped fiber amplifier according to the user instruction;

[0021] The thulium-doped fiber laser receives a control instruction from a control unit, and outputs laser pulses to the thulium-doped fiber amplifier according to the control instruction;

[0022] The thulium-doped fiber amplifier receives a control instruction from a control unit, sets a laser amplification factor according to the control instruction, receives a laser pulse sent by a thulium-doped fiber laser, amplifies the laser pulse, and sends the amplified laser pulse to a fiber coupler;

[0023] The optical fiber coupler receives the amplified laser pulse, couples the amplified laser pulse, and sends the coupled laser pulse to the gravel optical fiber;

[0024] The lithotripsy optical fiber receives the coupled laser pulses and applies the coupled laser pulses to the stones or adhesive tissues of the stone patient.

[0025] Furthermore, a pre-pulse thulium laser lithotripsy method also includes: a semiconductor laser receives instructions from a control unit to generate a 450nm blue laser, the 450nm blue laser is combined with the thulium laser through a reflection device and a laser beam combining device, and is coupled into the lithotripsy optical fiber through a laser fiber coupler, and the stone adhesion tissue is pre-bleached under the control of the control unit.

[0026] In a third aspect, an embodiment of the present invention discloses an electronic device, including:

[0027] one or more processors;

[0028] A memory for storing one or more programs;

[0029] When the one or more programs are executed by the one or more processors, the one or more processors implement the laser lithotripsy method.

[0030] The beneficial effects of the above technical solution provided by the embodiment of the present invention include at least:

[0031] The present invention can realize high peak power nanosecond pulses through the combination of a thulium-doped fiber laser and a thulium-doped fiber amplifier with a MOPA structure, and instantly generate micro-explosion bubbles without additional energy loss. Therefore, two pre-pulse energies of 20mJ in total can form an effective laser channel, so that high-energy laser pulses can act on stones, greatly improving the efficiency of micro-explosion lithotripsy and reducing thermal redundancy; small-core diameter and small numerical aperture lithotripsy optical fiber greatly improves energy concentration, further improves lithotripsy efficiency per unit energy, reduces thermal redundancy, and improves lithotripsy effect; utilizing the bleaching effect of 450nm semiconductor laser on hemoglobin, the stone adhesion tissue can be pre-bleached to avoid bleeding interference during surgery and improve surgical effect.

[0032] The technical solution of the present invention is further described in detail below through the accompanying drawings and embodiments. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. In the accompanying drawings:

[0034] Figure 1 This is a structural diagram of a pre-pulse thulium laser lithotripsy system in Example 1 of the present invention;

[0035] Figure 2 This is a schematic diagram of the structure of an electronic device in Example 3 of the present invention. DETAILED DESCRIPTION

[0036] The exemplary embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. Although the exemplary embodiments of the present disclosure are shown in the accompanying drawings, it should be understood that the present disclosure can be implemented in various forms and should not be limited by the embodiments set forth herein. On the contrary, these embodiments are provided to enable a more thorough understanding of the present disclosure and to fully convey the scope of the present disclosure to those skilled in the art.

[0037] In order to solve the problems existing in the prior art, an embodiment of the present invention provides a pre-pulse thulium laser lithotripsy system and method.

[0038] Example 1

[0039] The present invention discloses a pre-pulsed thulium laser lithotripsy system. Figure 1 , comprising: an interaction unit 1, a control unit 2, a thulium-doped fiber laser 9, a thulium-doped fiber amplifier 8, a laser fiber coupler 6 and a gravel fiber 5; wherein:

[0040] The output end of the interaction unit 1 is connected to the input end of the control unit 2, and is used to receive user instructions and forward the user instructions to the control unit 2;

[0041] The input end of the control unit 2 is connected to the interactive unit 1, and the output end is connected to the thulium-doped fiber laser 9 and the thulium-doped fiber amplifier 8, for receiving the user instructions and controlling the thulium-doped fiber laser 9 and the thulium-doped fiber amplifier 8 according to the user instructions;

[0042] The input end of the thulium-doped fiber laser 9 is connected to the control unit 2, and the output end is connected to the thulium-doped fiber amplifier 8, for receiving control instructions from the control unit 2, and outputting laser pulses to the thulium-doped fiber amplifier 8 according to the control instructions;

[0043] The input end of the thulium-doped fiber amplifier 8 is connected to the control unit 2 and the thulium-doped fiber laser 9, and the output end is connected to the laser fiber coupler 6, and is used to receive the control instruction of the control unit 2, set the laser amplification factor according to the control instruction, and receive the laser pulse sent by the thulium-doped fiber laser 9, amplify the laser pulse, and send the amplified laser pulse to the fiber coupler 6;

[0044] The input end of the fiber coupler 6 is connected to the thulium-doped fiber amplifier 8, and the output end is connected to the gravel fiber 5, for receiving the amplified laser pulse, coupling the amplified laser pulse, and sending the coupled laser pulse to the gravel fiber 5;

[0045] The input end of the lithotripsy optical fiber 5 is connected to the optical fiber coupler 6 for receiving coupled laser pulses and applying the coupled laser pulses to the stone-adherent tissue of the stone patient.

[0046] Among them, thulium-doped fiber laser is a fiber laser that uses rare earth-doped fiber as the gain medium. Its basic structure mainly includes devices such as pump source, coupler, rare earth-doped fiber and resonant cavity. The working principle of thulium-doped fiber laser is similar to other fiber lasers, which are based on population inversion, optical feedback and threshold conditions for laser oscillation. When the pump light passes through the doped fiber, it is absorbed by the rare earth ions in the fiber core, causing the rare earth ions to transition to the upper energy level of the laser, forming a population inversion. The inverted population transitions to the lower energy level of the laser through spontaneous radiation or stimulated radiation, releasing photons. When these photons form a feedback loop in the resonant cavity, laser oscillation is formed and laser output is generated.

[0047] In this embodiment, the output end of the interactive unit 1 is connected to the input end of the control unit 2 for receiving user instructions, wherein the user instructions include at least the start and end states of the thulium-doped fiber laser 9, the pulse frequencies of the thulium-doped fiber laser 9 and the thulium-doped fiber amplifier 8, and the amplification factor of the thulium-doped fiber amplifier 8.

[0048] In this embodiment, after receiving the user instruction, the control unit 2 sends a TTL signal to the thulium-doped fiber laser 9 and the thulium-doped fiber amplifier 8 to control the thulium-doped fiber laser 9 and the thulium-doped fiber amplifier 8.

[0049] In this embodiment, the thulium-doped fiber laser 9 is a 1940nm thulium-doped fiber laser 9 with a MOPA structure. The thulium-doped fiber laser 9 with a MOPA structure outputs three pulses under the control of the TTL signal output by the control unit 2, wherein the first two pulses are lithotripsy pre-pulses with a pulse width of 100 nanoseconds, and the last pulse is a high-energy pulse with a pulse width of 100 microseconds.

[0050] In this embodiment, the thulium-doped fiber amplifier 8 receives the laser pulse sent by the thulium-doped fiber laser 9 and amplifies the laser pulse. The specific method includes: the TTL signal that turns on the thulium-doped fiber amplifier 8 controls the TTL signal of the laser output pre-pulse to start hundreds of microseconds in advance, and the thulium-doped fiber is pumped in advance to form a large number of particle inversion accumulations, so that the first two pre-pulses of the thulium-doped fiber laser 9 are amplified to a preset peak power.

[0051] In some preferred embodiments, the core diameter of the stone crushing optical fiber 5 is 200μm, the maximum aperture is 0.1, the first two pre-pulses of the thulium-doped fiber laser 9 have a pulse width of 100ns, and the energy of a single pre-pulse is 10mJ. Most of the first 10mJ of pre-pulse energy is instantly concentrated in tens of micrograms of water at the end of the optical fiber, causing the water to vaporize at high speed into 1mm micro-explosion bubbles, and the adjacent second pre-pulse continues to advance forward 1mm, forming a 2mm gas channel at the front end of the optical fiber; at this time, the laser outputs a third high-energy pulse concentrated on the stones, forming an effective micro-explosion to crush the stones.

[0052] Specifically, when the pre-pulse thulium laser lithotripsy system is working, the thulium-doped fiber amplifier 8 is controlled by the control unit 2 to pump the thulium-doped fiber 100 μs in advance, such as Figure 2 At t4, a large number of population inversion accumulations are formed, and at this time, the pulse width of the two pre-pulses of the thulium-doped fiber laser 9 is 100ns. Figure 2 In the case of t1=t2, it is amplified to a very high peak power, and the energy of a single pre-pulse is 10mJ. The core diameter of the lithotripsy fiber 5 is 200μm, and the aperture is 0.1. According to the absorption intensity of the 1940nm thulium laser in water, most of the first 10mJ pre-pulse energy is instantly concentrated in the tens of micrograms of water at the end of the optical fiber, causing the water to vaporize at high speed into micro-explosion bubbles of about 1mm. The second pre-pulse next to it continues to advance 1mm, forming a 2mm gas channel at the front end of the optical fiber. At this time, the laser outputs a large energy pulse of 500mJ and concentrates it within 0.5mm of the stone diameter, forming an effective micro-explosion to crush the stone. Because of the instantaneous micro-explosion effect of the high-peak pre-pulse, the energy will not be gradually dissipated and wasted. Only 20mJ of energy can form an effective bubble channel for transmitting thulium laser, which greatly reduces thermal redundancy and improves the lithotripsy effect.

[0053] In some preferred embodiments, a pre-pulse thulium laser lithotripsy system also includes a semiconductor laser 3, a reflecting device 4 and a laser beam combining device 7; the input end of the semiconductor laser 3 is connected to the control unit 2, and the output end is connected to the reflecting device 4; the input end of the reflecting device is connected to the semiconductor laser 3, and the output end is connected to the laser beam combining device 7; the input end of the laser beam combining device 7 is connected to the thulium-doped fiber amplifier 8 and the reflecting device 4, and the output end is connected to the laser fiber coupler 6; the semiconductor laser 3 receives instructions from the control unit 2 to generate a 450nm blue laser, and the 450nm blue laser is combined with the thulium laser amplified by the thulium-doped fiber amplifier 8 through the reflecting device 4 and the laser beam combining device 7, and is coupled into the lithotripsy fiber 5 through the laser fiber coupler 6, and the stone adhesion tissue can be pre-bleached under the control of the control unit 2.

[0054] A pre-pulse thulium laser lithotripsy system disclosed in the present embodiment can realize high peak power nanosecond pulses through the combination of a thulium-doped fiber laser and a thulium-doped fiber amplifier with a MOPA structure, and instantly generate micro-explosion bubbles without additional energy loss. Therefore, two pre-pulse energies of 20mJ can form an effective laser channel, allowing high-energy lasers to act on stones, greatly improving the efficiency of micro-explosion lithotripsy and reducing thermal redundancy; the small-core diameter and small-numerical-aperture lithotripsy optical fiber greatly improves energy concentration, further improves the lithotripsy efficiency per unit energy, reduces thermal redundancy, and improves the lithotripsy effect; the bleaching effect of a 450nm semiconductor laser and hemoglobin can be used to pre-bleach the stone-adherent tissue, so that the operation can be free from bleeding interference and the surgical effect can be improved.

[0055] Example 2

[0056] Based on the pre-pulse thulium laser lithotripsy system in Example 1, this embodiment discloses a pre-pulse thulium laser lithotripsy method, including:

[0057] The interaction unit receives the user instruction and forwards the user instruction to the control unit;

[0058] The control unit receives the user instruction and controls the thulium-doped fiber laser and the thulium-doped fiber amplifier according to the user instruction;

[0059] The thulium-doped fiber laser receives a control instruction from a control unit, and outputs laser pulses to the thulium-doped fiber amplifier according to the control instruction;

[0060] The thulium-doped fiber amplifier receives a control instruction from a control unit, sets a laser amplification factor according to the control instruction, receives a laser pulse sent by a thulium-doped fiber laser, amplifies the laser pulse, and sends the amplified laser pulse to a fiber coupler;

[0061] The optical fiber coupler receives the amplified laser pulse, couples the amplified laser pulse, and sends the coupled laser pulse to the gravel optical fiber;

[0062] The lithotripsy optical fiber receives the coupled laser pulses and applies the coupled laser pulses to the stone-adherent tissue of the stone patient.

[0063] In some preferred embodiments, a pre-pulse thulium laser lithotripsy method also includes: a semiconductor laser receives instructions from a control unit to generate a 450nm blue laser, the 450nm blue laser is combined with the thulium laser reflected by a thulium-doped fiber amplifier through a reflection device and a laser beam combining device, and is coupled into the lithotripsy optical fiber through a laser fiber coupler, and the stone adhesion tissue can be pre-bleached under the control of the control unit.

[0064] Among them, the specific working methods of the interactive unit, control unit, thulium-doped fiber laser, thulium-doped fiber amplifier, laser fiber coupler, gravel fiber, semiconductor laser, reflection device and laser beam combining device have been described in detail in Example 1, and will not be repeated here in this embodiment.

[0065] Example 3

[0066] Based on the same inventive concept, an embodiment of the present disclosure also provides an electronic device. Figure 2 FIG. 1 is a schematic diagram of the structure of an electronic device according to an embodiment of the present disclosure. Figure 2As shown, an embodiment of the present disclosure provides an electronic device including: one or more processors 101, a memory 102, and one or more I / O interfaces 103. The memory 102 stores one or more programs, and when the one or more programs are executed by the one or more processors, the one or more processors implement any optimization method in the above embodiments; the one or more I / O interfaces 103 are connected between the processor and the memory, and are configured to implement information interaction between the processor and the memory.

[0067] Among them, the processor 101 is a device with data processing capabilities, including but not limited to a central processing unit (CPU), etc.; the memory 102 is a device with data storage capabilities, including but not limited to random access memory (RAM, more specifically SDRAM, DDR, etc.), read-only memory (ROM), electrically erasable programmable read-only memory (EEPROM), flash memory (FLASH); the I / O interface (read-write interface) 103 is connected between the processor 101 and the memory 102, and can realize information interaction between the processor 101 and the memory 102, including but not limited to a data bus (Bus), etc.

[0068] In some embodiments, the processor 101 , the memory 102 , and the I / O interface 103 are connected to each other via a bus 104 , and further connected to other components of the computing device.

[0069] In some embodiments, the one or more processors 101 include a field programmable gate array.

[0070] According to an embodiment of the present disclosure, a computer-readable medium is further provided, wherein a computer program is stored on the computer-readable medium, wherein when the program is executed by a processor, the steps in any optimization method in the above-mentioned embodiment are implemented.

[0071] It should be understood that the specific order or hierarchy of steps in the disclosed process is an example of an exemplary method. Based on design preferences, it should be understood that the specific order or hierarchy of steps in the process can be rearranged without departing from the scope of protection of the present disclosure. The attached method claims present the elements of the various steps in an exemplary order and are not intended to be limited to the specific order or hierarchy described.

[0072] In the above detailed description, various features are grouped together in a single embodiment to simplify the disclosure. This method of disclosure should not be interpreted as reflecting an intention that the embodiments of the claimed subject matter require more features than are clearly stated in each claim. On the contrary, as reflected in the appended claims, the invention is in a state of having less than all the features of the disclosed individual embodiments. Therefore, the appended claims are hereby expressly incorporated into the detailed description, with each claim standing on its own as a separate preferred embodiment of the invention.

[0073] Those skilled in the art will also appreciate that the various illustrative logic blocks, modules, circuits, and algorithmic steps described in conjunction with the embodiments herein can all be implemented as electronic hardware, computer software, or a combination thereof. In order to clearly illustrate the interchangeability between hardware and software, various illustrative components, blocks, modules, circuits, and steps are generally described above around their functions. Whether such functions are implemented as hardware or software depends on specific applications and the design constraints imposed on the entire system. A skilled person can implement the described functions in an alternative manner for each specific application, but such implementation decisions should not be interpreted as departing from the scope of protection of the present disclosure.

[0074] The steps of the method or algorithm described in conjunction with the embodiments herein may be directly embodied as hardware, a software module executed by a processor, or a combination thereof. The software module may be located in a RAM memory, a flash memory, a ROM memory, an EPROM memory, an EEPROM memory, a register, a hard disk, a mobile disk, a CD-ROM, or any other form of storage medium well known in the art. An exemplary storage medium is connected to the processor so that the processor can read information from the storage medium and can write information to the storage medium. Of course, the storage medium may also be an integral part of the processor. The processor and the storage medium may be located in an ASIC. The ASIC may be located in a user terminal. Of course, the processor and the storage medium may also be present in a user terminal as discrete components.

[0075] For software implementation, the techniques described in this application can be implemented with modules (e.g., procedures, functions, etc.) that perform the functions described in this application. These software codes can be stored in a memory unit and executed by a processor. The memory unit can be implemented within the processor or outside the processor. In the latter case, it is coupled to the processor in a communication manner via various means, which are well known in the art.

[0076] The above description includes examples of one or more embodiments. Of course, it is impossible to describe all possible combinations of components or methods for the purpose of describing the above embodiments, but it should be recognized by those skilled in the art that the various embodiments may be further combined and arranged. Therefore, the embodiments described herein are intended to cover all such changes, modifications and variations that fall within the scope of protection of the appended claims. In addition, with respect to the term "comprising" used in the specification or claims, the word is covered in a manner similar to the term "including", just as "including," is explained as a transitional word in the claims. In addition, any term "or" used in the specification of the claims is intended to mean "non-exclusive or".

Claims

1. A pre-pulsed thulium laser lithotripsy system, characterized in that: include: An interaction unit, a control unit, a thulium-doped fiber laser, a thulium-doped fiber amplifier, a laser fiber coupler and a gravel fiber; wherein: The output end of the interaction unit is connected to the input end of the control unit, and is used to receive user instructions and forward the user instructions to the control unit; The input end of the control unit is connected to the interactive unit, and the output end is connected to the thulium-doped fiber laser and the thulium-doped fiber amplifier, for receiving the user instruction and controlling the thulium-doped fiber laser and the thulium-doped fiber amplifier according to the user instruction; The input end of the thulium-doped fiber laser is connected to the control unit, and the output end is connected to the thulium-doped fiber amplifier, for receiving control instructions from the control unit, and outputting laser pulses to the thulium-doped fiber amplifier according to the control instructions; The input end of the thulium-doped fiber amplifier is connected to the control unit and the thulium-doped fiber laser, and the output end is connected to the laser fiber coupler, and is used to receive control instructions from the control unit, set the laser amplification factor according to the control instructions, and receive laser pulses sent by the thulium-doped fiber laser, amplify the laser pulses, and send the amplified laser pulses to the fiber coupler; The input end of the fiber coupler is connected to the thulium-doped fiber amplifier, and the output end is connected to the gravel fiber, and is used to receive the amplified laser pulse, couple the amplified laser pulse, and send the coupled laser pulse to the gravel fiber; The input end of the lithotripsy optical fiber is connected to a fiber coupler for receiving coupled laser pulses and applying the coupled laser pulses to the stones or adhesive tissues of the stone patient.

2. A pre-pulsed thulium laser lithotripsy system as claimed in claim 1, characterized in that: The output end of the interactive unit is connected to the input of the control unit for receiving user instructions, wherein the user instructions at least include the start and end states of the thulium-doped fiber laser, the pulse frequencies of the thulium-doped fiber laser and the thulium-doped fiber amplifier, and the amplification factor of the thulium-doped fiber amplifier.

3. A pre-pulsed thulium laser lithotripsy system as claimed in claim 1, characterized in that: After receiving the user instruction, the control unit controls the thulium-doped fiber laser and the thulium-doped fiber amplifier by sending a TTL signal to the thulium-doped fiber laser and the thulium-doped fiber amplifier.

4. A pre-pulsed thulium laser lithotripsy system as claimed in claim 3, characterized in that: The thulium-doped fiber laser is a thulium-doped fiber laser with a MOPA structure. The thulium-doped fiber laser with a MOPA structure outputs three pulses under the control of a TTL signal output by a control unit, wherein the first two pulses are lithotripsy pre-pulses with a pulse width of 100 nanoseconds, and the last pulse is a high-energy pulse with a pulse width of 100 microseconds.

5. A pre-pulsed thulium laser lithotripsy system as claimed in claim 4, characterized in that: The thulium-doped fiber amplifier receives the laser pulse sent by the thulium-doped fiber laser and amplifies the laser pulse. The specific method includes: the TTL signal for starting the thulium-doped fiber amplifier controls the TTL signal for outputting the pre-pulse of the laser to start hundreds of microseconds in advance, and the thulium-doped fiber is pumped in advance to form a large number of particle inversion accumulations, so that the first two pre-pulses of the thulium-doped fiber laser are amplified to a preset peak power.

6. A pre-pulsed thulium laser lithotripsy system as claimed in claim 5, characterized in that: The core diameter of the stone-breaking optical fiber is 200μm, and the maximum aperture is 0.

1. The first two pre-pulses of the thulium-doped fiber laser have a pulse width of 100ns, and the energy of a single pre-pulse is 10mJ. Most of the first 10mJ pre-pulse energy is instantly concentrated in tens of micrograms of water at the end of the optical fiber, causing the water to vaporize at high speed into 1mm micro-explosion bubbles. The second adjacent pre-pulse continues to advance forward 1mm, forming a 2mm gas channel at the front end of the optical fiber; at this time, the laser outputs a third high-energy pulse to concentrate on the stones, forming an effective micro-explosion to crush the stones.

7. The pre-pulse thulium laser lithotripsy system according to claim 1, characterized in that: It also includes a semiconductor laser, a reflecting device and a laser beam combining device; the input end of the semiconductor laser is connected to the control unit, and the output end is connected to the reflecting device; the input end of the reflecting device is connected to the semiconductor laser, and the output end is connected to the laser beam combining device; the input end of the laser beam combining device is connected to the thulium-doped fiber amplifier and the reflecting device, and the output end is connected to the laser fiber coupler; the semiconductor laser receives instructions from the control unit to generate a 450nm blue laser, and the 450nm blue laser is combined with the thulium laser amplified by the thulium-doped fiber amplifier through the reflecting device and the laser beam combining device, and is coupled into the lithotripsy fiber through the laser fiber coupler, and the stone adhesion tissue is pre-bleached under the control of the control unit.

8. A pre-pulsed thulium laser lithotripsy method, characterized in that: include: The interaction unit receives the user instruction and forwards the user instruction to the control unit; The control unit receives the user instruction and controls the thulium-doped fiber laser and the thulium-doped fiber amplifier according to the user instruction; The thulium-doped fiber laser receives a control instruction from a control unit, and outputs laser pulses to the thulium-doped fiber amplifier according to the control instruction; The thulium-doped fiber amplifier receives a control instruction from a control unit, sets a laser amplification factor according to the control instruction, receives a laser pulse sent by a thulium-doped fiber laser, amplifies the laser pulse, and sends the amplified laser pulse to a fiber coupler; The optical fiber coupler receives the amplified laser pulse, couples the amplified laser pulse, and sends the coupled laser pulse to the gravel optical fiber; The lithotripsy optical fiber receives the coupled laser pulses and applies the coupled laser pulses to the stone-adherent tissue of the stone patient.

9. A pre-pulsed thulium laser lithotripsy method, characterized in that: Also includes: The semiconductor laser receives instructions from the control unit to generate a 450nm blue laser, which is combined with the thulium laser amplified by the thulium-doped fiber amplifier through a reflection device and a laser beam combining device, and is coupled into the lithotripsy fiber through a laser fiber coupler. Under the control of the control unit, the stone-adhering tissue can be pre-bleached.

10. An electronic device, comprising: one or more processors; A memory for storing one or more programs; When the one or more programs are executed by the one or more processors, the one or more processors implement the laser lithotripsy method of claims 8-9.

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