Colloid osmotic pressure tester

Abstract

The invention discloses a colloid osmotic pressure tester which comprises a shell, and a semi-permeable membrane replacement mechanism, a machine body auxiliary module and a controller which are mounted in the shell, the semi-permeable membrane replacement mechanism is detachably connected with a semi-permeable membrane fixing device and a reagent bag, and a semi-permeable membrane is arranged in the semi-permeable membrane fixing device; the controller is in communication connection with the semi-permeable membrane replacement mechanism and the machine body auxiliary module, and the machine body auxiliary module is used for inputting and outputting information, controlling the semi-permeable membrane replacement mechanism to drive the semi-permeable membrane fixing device and the reagent bag to automatically pop up, and adding a sample into the semi-permeable membrane fixing device for osmotic pressure measurement. The semi-permeable membrane replacing mechanism drives the semi-permeable membrane fixing device to turn over, so that the semi-permeable membrane fixing device is convenient to replace, the internal semi-permeable membrane is further replaced, the reagent bag is rapidly replaced, the mounting process is simplified, automatic control is realized, and the working efficiency is improved.

Description

Technical Field

[0001] The invention relates to the field of medical equipment, in particular to a colloid osmotic pressure measuring instrument. Background Art

[0002] The colloid osmotic pressure meter is a widely used medical device used to detect the osmotic pressure of colloids. It tests and analyzes the human immune system by testing the patient's plasma or whole blood. The colloid osmotic pressure is generated by macromolecular solutes such as proteins in the plasma. It regulates and controls the exchange and balance of water inside and outside the capillaries. Therefore, the determination of colloid osmotic pressure has become an indispensable detection indicator in the monitoring, diagnosis, treatment and prognosis of diseases such as pulmonary edema, cerebral edema and pregnancy-induced hypertension syndrome.

[0003] Among them, the semipermeable membrane is an important component to realize the above functions. The protein in the sample cannot pass through the semipermeable membrane. Therefore, in the process of measuring the colloidal osmotic pressure value of the sample, due to the existence of colloidal osmotic pressure, the sample will absorb ions and small molecules on the other side of the semipermeable membrane to offset the colloidal osmotic pressure value. Therefore, the semipermeable membrane must be replaced when its service life is reached.

[0004] In the prior art, the semipermeable membrane replacement method is: first, the semipermeable membrane is soaked until it is completely wetted, then the semipermeable membrane top screw cap is manually unscrewed, the sealing ring and the old semipermeable membrane are taken out, the cavity below the semipermeable membrane is cleaned, and a reference solution is injected, then the new semipermeable membrane is installed, the sealing ring is installed, and then the screw cap is tightened. The above-mentioned semipermeable membrane replacement method makes the replacement of the semipermeable membrane process complicated, and there is a high failure rate caused by too many human operations, and the replacement time is long. Generally, the semipermeable membrane is manually cleaned, which not only easily damages the semipermeable membrane, but also there will be situations such as the semipermeable membrane is not cleaned properly, and more importantly, it is necessary to provide a cleaning solution separately, and the waste liquid measured and cleaned in addition can not be collected, resulting in a complicated cleaning process and reduced work efficiency.

[0005] Therefore, how to provide a colloid osmotic pressure measuring instrument that can quickly and efficiently replace a semipermeable membrane is a technical problem that those skilled in the art currently need to solve. Summary of the invention

[0006] The purpose of the present invention is to provide a colloidal osmotic pressure measuring instrument, which drives a semipermeable membrane fixing device to flip through a semipermeable membrane replacement mechanism, facilitates the replacement of the semipermeable membrane fixing device, and then replaces the internal semipermeable membrane, and quickly replaces the reagent package, simplifies the installation process, realizes automatic control, and improves work efficiency.

[0007] In order to solve the above technical problems, the present invention provides a colloid osmotic pressure measuring instrument, including a shell and a semipermeable membrane replacement mechanism, a body auxiliary module and a controller installed in the shell, the semipermeable membrane replacement mechanism is detachably connected to a semipermeable membrane fixing device and a reagent pack, the semipermeable membrane fixing device is provided with a semipermeable membrane, the controller is communicatively connected to the semipermeable membrane replacement mechanism and the body auxiliary module, the body auxiliary module is used for information input and output, controls the semipermeable membrane replacement mechanism to drive the semipermeable membrane fixing device and the reagent pack to automatically pop out, and adds the sample to the semipermeable membrane fixing device for osmotic pressure measurement.

[0008] Preferably, the semipermeable membrane replacement mechanism includes a base plate and a mounting platform installed above the base plate, a reagent driving structure, a flow control mechanism, a replacement driving mechanism and a transmission mechanism. The semipermeable membrane fixing device can be detachably mounted on the mounting platform. A conveying mechanism connected to the interior of the semipermeable membrane fixing device is arranged below the mounting platform. The reagent driving structure is connected to the conveying mechanism through the flow control mechanism, and is used to allow different reagents to be input or discharged from the interior of the semipermeable membrane fixing device. The replacement driving mechanism is connected to the mounting platform through the transmission mechanism, and is used to drive the mounting platform to flip forward so that the upper end of the semipermeable membrane fixing device tilts forward, or to drive the mounting platform to flip backward so that the semipermeable membrane fixing device is restored to a vertical state.

[0009] Preferably, the replacement drive mechanism is a vertically arranged linear motor, the transmission mechanism includes a base, a transmission plate and a connecting rod, the mounting platform is located at the front end of the base plate, the base is located at the rear end of the base plate, the mounting platform is hinged to the base, the rear end of the transmission plate is hinged to the base, a slide groove is provided on the lower surface of the middle part of the transmission plate, the upper end of the lead screw of the linear motor is connected to a transmission shaft, the transmission shaft is installed in the slide groove, the upper end of the connecting rod is hinged to the front end of the transmission plate, and the lower end of the connecting rod is hinged to the rear end of the mounting platform.

[0010] Preferably, the reagent pack is detachably mounted under the base plate, the puncture needle under the base plate is inserted into the reagent pack, the flow control mechanism is connected to the reagent pack through the puncture needle, an active buckle is provided under the base plate, the active buckle is engaged with the upper end of the reagent pack, and the lower end of the screw rod of the linear motor can trigger the active buckle to unlock so as to pop out the reagent pack.

[0011] Preferably, the semipermeable membrane fixing device includes a reference chamber container and a measuring chamber container, the reference chamber container is provided with a reference cavity, the measuring chamber container is provided with a measuring cavity and a liquid pipeline connected with the measuring cavity, the reference chamber container is installed below the measuring chamber container, and the upper end of the reference cavity is connected with the lower end of the measuring cavity, a supporting sieve plate is installed at the upper end of the reference cavity, the supporting sieve plate is covered with a semipermeable membrane, and a connecting structure for detachably connecting the reference chamber working hole of the colloid osmotic pressure measuring instrument is provided on the outer periphery of the reference chamber container.

[0012] Preferably, the reagent pack includes a box body and an upper cover snapped onto the upper opening of the box body, a plurality of reagent bags are installed in the box body, a plurality of delivery holes are provided on the upper cover, a sealing rubber plug is installed in each of the delivery holes, a delivery tube is connected to the rear end of the sealing rubber plug, each of the delivery tubes is respectively connected to a plurality of the reagent bags, and a docking structure for detachably connecting to a measuring instrument body is provided on the upper end surface of the upper cover. During installation, a plurality of puncture needles below the measuring instrument body respectively pass through each of the sealing rubber plugs to conduct the corresponding reagent bags.

[0013] Preferably, the docking structure includes a snap groove arranged in the middle of the upper end surface of the upper cover and guide grooves arranged at both ends of the upper end surface in the length direction, and the lower end surface of the box body is provided with a guide groove, and the snap groove, the guide groove and the guide groove all extend along the width direction.

[0014] Preferably, the body auxiliary module includes a first diaphragm pump, a second diaphragm pump and a gas-liquid separation bottle, the first diaphragm pump is respectively connected to the inside of the semipermeable membrane fixing device and the upper end of the gas-liquid separation bottle, and the second diaphragm pump is respectively connected to the lower end of the gas-liquid separation bottle and the reagent package.

[0015] Preferably, the body auxiliary module also includes a filter, a network cable extension cable, a barcode scanner, a thermal printer and a screen, the filter is used to filter out interference frequencies and provide stable voltage, the barcode scanner is used to enter information, and the screen is used to operate the software and display measurement results.

[0016] Preferably, the screen is arranged above the shell, the barcode scanner and the thermal printer are arranged in front of the shell, a window is arranged in front of the shell, a door is installed at the window, and the semipermeable membrane fixing device can extend from the window.

[0017] The present invention provides a colloid osmotic pressure measuring instrument, comprising a shell, a semipermeable membrane replacement mechanism, a body auxiliary module and a controller installed in the shell, the semipermeable membrane replacement mechanism can be detachably connected to a semipermeable membrane fixing device and a reagent pack, a semipermeable membrane is arranged in the semipermeable membrane fixing device, the controller is communicatively connected to the semipermeable membrane replacement mechanism and the body auxiliary module, the body auxiliary module is used for information input and output, controls the semipermeable membrane replacement mechanism to drive the semipermeable membrane fixing device and the reagent pack to automatically pop out, and adds a sample into the semipermeable membrane fixing device to perform osmotic pressure measurement.

[0018] When the semipermeable membrane needs to be replaced, the semipermeable membrane replacement mechanism drives the semipermeable membrane fixing device to automatically pop out and extend out of the installation position, which is convenient for removing the old semipermeable membrane fixing device, and then installing a new semipermeable membrane fixing device. The semipermeable membrane replacement mechanism drives the semipermeable membrane fixing device to reset, and the semipermeable membrane fixing device returns to a vertical state. When the reagent pack needs to be replaced, the semipermeable membrane replacement mechanism drives the old reagent pack, and then installs the new reagent pack.

[0019] The semipermeable membrane replacement mechanism drives the semipermeable membrane fixing device to flip, which facilitates the replacement of the semipermeable membrane fixing device, and then replaces the internal semipermeable membrane, and quickly replaces the reagent package, simplifies the installation process, realizes automatic control, and improves work efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] FIG1 is a schematic structural diagram of a specific embodiment of a colloid osmotic pressure measuring instrument provided by the present invention;

[0021] FIG2 is a schematic structural diagram of a semipermeable membrane replacement mechanism in a specific embodiment of the colloid osmotic pressure measuring instrument provided by the present invention;

[0022] FIG3 is a cross-sectional schematic diagram of a semipermeable membrane replacement mechanism in a specific embodiment of the colloid osmotic pressure measuring instrument provided by the present invention;

[0023] FIG4 is a bottom view schematically showing a semipermeable membrane replacement mechanism in a specific embodiment of the colloid osmotic pressure measuring instrument provided by the present invention;

[0024] FIG5 is a schematic diagram of the internal structure of a semipermeable membrane fixing device in a specific embodiment of the colloid osmotic pressure measuring instrument provided by the present invention;

[0025] FIG6 is a schematic diagram of the external structure of a semipermeable membrane fixing device in a specific embodiment of the colloid osmotic pressure measuring instrument provided by the present invention;

[0026] 7 is a cross-sectional schematic diagram of a reference chamber container of a semipermeable membrane fixing device in a specific embodiment of the colloid osmotic pressure measuring instrument provided by the present invention;

[0027] FIG8 is a cross-sectional schematic diagram of a measuring chamber container of a semipermeable membrane fixing device in a specific embodiment of a colloid osmotic pressure measuring instrument provided by the present invention;

[0028] FIG9 is a schematic top view of a supporting sieve plate of a semipermeable membrane fixing device in a specific embodiment of a colloid osmotic pressure measuring instrument provided by the present invention;

[0029] FIG10 is a schematic diagram of the structure of a reagent package in a specific embodiment of the colloid osmotic pressure measuring instrument provided by the present invention;

[0030] FIG11 is a schematic diagram of an exploded view of a reagent package in a specific embodiment of a colloid osmotic pressure measuring instrument provided by the present invention;

[0031] FIG12 is a bottom view of an upper cover of a reagent pack in a specific embodiment of the colloid osmotic pressure measuring instrument provided by the present invention;

[0032] FIG13 is a side cross-sectional view of an upper cover of a reagent pack in a specific embodiment of the colloid osmotic pressure measuring instrument provided by the present invention;

[0033] 14 is a schematic diagram of the installation of a support plate of a reagent pack in a specific embodiment of the colloid osmotic pressure measuring instrument provided by the present invention;

[0034] FIG15 is a bottom view of a support plate of a reagent pack in a specific embodiment of the colloid osmotic pressure measuring instrument provided by the present invention;

[0035] FIG16 is a schematic diagram of the internal structure of a specific embodiment of the colloid osmotic pressure measuring instrument provided by the present invention;

[0036] FIG. 17 is a schematic diagram of the structure of a controller in a specific embodiment of the colloid osmotic pressure measuring instrument provided by the present invention.

[0037] Among them, the housing 1, the semipermeable membrane replacement mechanism 2, the body auxiliary module 3, the controller 4, the semipermeable membrane fixing device 5, and the reagent package 6;

[0038] Bottom plate 2-1, mounting platform 2-2, linear motor 2-4, base 2-5, transmission plate 2-6, connecting rod 2-7, slide groove 2-8, screw rod 2-9, transmission shaft 2-10, sealing column 2-11, peristaltic pump 2-12, pinch valve 2-13, sample adding handle 2-14, movable buckle 2-15, puncture needle 2-16, guide hook 2-17;

[0039] Reference chamber container 5-1, upper sealing section 5-11, sieve plate installation section 5-12, upper conical transition section 5-13, middle section 5-14, lower conical transition section 5-15, lower sealing section 5-16, annular groove 5-17, limiting step 5-18, measuring chamber container 5-2, measuring cavity 5-21, installation hole 5-22, process hole 5-23, boss 5-24, supporting sieve plate 5-3, sieve hole 5-31, semipermeable membrane 5-4, upper sealing ring 5-5, plug 5-6, lower sealing ring, connecting plate 5-7, catheter 5-8, silicone tube 5-9;

[0040] Box body 6-1, upper cover 6-2, reagent bag 6-3, delivery hole 6-4, sealing plug 6-5, delivery tube 6-6, one-way valve 6-7, mounting seat 6-8, clamping claw 6-9, buckle groove 6-10, guide groove 6-11, guide rail groove 6-12, buckle structure 6-13, support plate 6-14. DETAILED DESCRIPTION

[0041] The core of the present invention is to provide a colloidal osmotic pressure measuring instrument, which drives the semipermeable membrane fixing device to flip through the semipermeable membrane replacement mechanism, facilitates the replacement of the semipermeable membrane fixing device, and then replaces the internal semipermeable membrane, and quickly replaces the reagent package, simplifies the installation process, realizes automatic control, and improves work efficiency.

[0042] In order to enable those skilled in the art to better understand the solution of the present invention, the present invention is further described in detail below in conjunction with the accompanying drawings and specific implementation methods.

[0043] Please refer to FIG. 1 , which is a schematic structural diagram of a specific implementation of a colloid osmotic pressure measuring instrument provided by the present invention.

[0044] A colloid osmotic pressure measuring instrument, characterized in that it includes a shell 1 and a semipermeable membrane replacement mechanism 2, a body auxiliary module 3 and a controller 4 installed in the shell 1, the semipermeable membrane replacement mechanism 2 is detachably connected to a semipermeable membrane fixing device 5 and a reagent pack 6, a semipermeable membrane 5-4 is arranged in the semipermeable membrane fixing device 5, the controller 4 is communicatively connected to the semipermeable membrane replacement mechanism 2 and the body auxiliary module 3, the body auxiliary module 3 is used for information input and output, controls the semipermeable membrane replacement mechanism 2 to drive the semipermeable membrane fixing device 5 and the reagent pack 6 to automatically pop out, and adds the sample to the semipermeable membrane fixing device 5 for osmotic pressure measurement.

[0045] When the semipermeable membrane needs to be replaced, the semipermeable membrane replacement mechanism drives the semipermeable membrane fixing device to automatically pop out and extend out of the installation position, which is convenient for removing the old semipermeable membrane fixing device, and then installing a new semipermeable membrane fixing device. The semipermeable membrane replacement mechanism drives the semipermeable membrane fixing device to reset, and the semipermeable membrane fixing device returns to a vertical state. When the reagent pack needs to be replaced, the semipermeable membrane replacement mechanism drives the old reagent pack, and then installs the new reagent pack.

[0046] The semipermeable membrane replacement mechanism drives the semipermeable membrane fixing device to flip, which facilitates the replacement of the semipermeable membrane fixing device, and then replaces the internal semipermeable membrane, and quickly replaces the reagent package, simplifies the installation process, realizes automatic control, and improves work efficiency.

[0047] Please refer to Figures 2 to 4, Figure 2 is a structural schematic diagram of a semipermeable membrane replacement mechanism in a specific embodiment of the colloid osmotic pressure measuring instrument provided by the present invention; Figure 3 is a cross-sectional schematic diagram of a semipermeable membrane replacement mechanism in a specific embodiment of the colloid osmotic pressure measuring instrument provided by the present invention; Figure 4 is a bottom-up schematic diagram of a semipermeable membrane replacement mechanism in a specific embodiment of the colloid osmotic pressure measuring instrument provided by the present invention.

[0048] The semipermeable membrane replacement mechanism 2-2 includes a horizontally arranged bottom plate 2-1 and a mounting platform 2-2 installed above the bottom plate 2-1, a reagent driving structure, a flow control mechanism, a replacement driving mechanism and a transmission mechanism, wherein a semipermeable membrane fixture is detachably mounted on the mounting platform 2-2, a semipermeable membrane is installed inside the semipermeable membrane fixture, and it is a key component for osmotic pressure testing, and a conveying mechanism connected to the inside of the semipermeable membrane fixture is arranged below the mounting platform 2-2, which is used to convey reagents to the inside of the semipermeable membrane fixture, or discharge reagents inside the semipermeable membrane fixture. Further, the reagent driving structure is connected to the conveying mechanism through the flow control mechanism, which is used to input or discharge different reagents into or out of the semipermeable membrane fixture, the reagent driving structure provides power for the flow of the reagent, and the flow control mechanism is the flow control direction of the reagent, that is, the specific flow mode.

[0049] The replacement drive mechanism is connected to the installation platform 2-2 through the transmission mechanism. When the semipermeable membrane needs to be replaced, the replacement drive mechanism and the transmission mechanism drive the installation platform 2-2 to flip forward, and drive the upper end of the semipermeable membrane fixing device to tilt forward and extend out of the installation position to facilitate the removal of the old semipermeable membrane fixing device, and then install the new semipermeable membrane fixing device. The replacement drive mechanism and the transmission mechanism drive the installation platform 2-2 to flip backward, and drive the upper end of the semipermeable membrane fixing device to flip backward, the semipermeable membrane fixing device returns to a vertical state, and continues the corresponding work.

[0050] By replacing the driving mechanism and the transmission mechanism, the installation platform 2-2 is driven to flip the semipermeable membrane fixing device, which is convenient for replacing the semipermeable membrane fixing device, and then replacing the internal semipermeable membrane, simplifying the installation process, realizing automatic control, and improving work efficiency.

[0051] Specifically, the drive mechanism is replaced with a vertically arranged linear motor 2-4, the transmission mechanism includes a base 2-5, a transmission plate 2-6 and a connecting rod 2-7, and the front end and the rear end are defined according to the position of the mounting platform 2-2. The mounting platform 2-2 is located at the front end of the bottom plate 2-1, and the base 2-5 is located at the rear end of the bottom plate 2-1. The front end of the mounting platform 2-2 is hinged to the bottom plate 2-1, and the rear end of the transmission plate 2-6 is hinged to the base 2-5. A connecting structure is provided on the lower surface of the middle part of the transmission plate 2-6, and a slide groove 2-8 is provided on the connecting structure. The upper end of the lead screw 2-9 of the linear motor 2-4 is connected to the transmission shaft 2-10, and the transmission shaft 2-10 is installed in the slide groove 2-8. The upper end of the connecting rod 2-7 is hinged to the front end of the transmission plate 2-6, and the lower end of the connecting rod 2-7 is hinged to the rear end of the mounting platform 2-2. Among them, the extension direction of the slide groove 2-8 is parallel to the transmission plate 2-6, and the connecting rod 2-7 is a bending member, and the lower end of the connecting rod 2-7 is bent forward.

[0052] When the semipermeable membrane inside the semipermeable membrane fixture reaches the service life, the semipermeable membrane needs to be replaced. At this time, the linear motor 2-4 drives the screw rod 2-9 to move upward, driving the transmission shaft 2-10 to move upward, while the transmission shaft 2-10 slides in the chute 2-8, it pushes the transmission plate 2-6 to move upward, and then drives the connecting rod 2-7 to move upward, and the installation platform 2-2 and the semipermeable membrane fixture will realize the flipping motion when the connecting rod 2-7 transmits power, swings forward, and stops moving after flipping to the corresponding angle. At this time, take out the semipermeable membrane fixture that reaches the service life, and replace it with a new semipermeable membrane fixture, and at this time, the semipermeable membrane fixture flips back to the original position and completes the replacement of the semipermeable membrane fixture. When the sound of the ball plunger and the prompt of the touch switch below the semipermeable membrane fixture 2-4 are heard during the replacement process, it means that the replacement is completed.

[0053] Preferably, the front end of the transmission plate 2-6 is provided with a sealing column 2-11 extending downward. When the semipermeable membrane needs to be replaced, the replacement drive mechanism and the transmission mechanism drive the installation platform 2-2 to flip forward, and drive the upper end of the semipermeable membrane fixture to tilt forward, and at the same time, the front end of the installation platform 2-2 drives the sealing column 2-11 to move upward, so that the sealing column 2-11 is separated from the upper end opening of the semipermeable membrane fixture. When the replacement is completed, the replacement drive mechanism and the transmission mechanism drive the installation platform 2-2 to flip backward, and drive the upper end of the semipermeable membrane fixture to flip backward, and the semipermeable membrane fixture returns to a vertical state. At the same time, the front end of the installation platform 2-2 drives the sealing column 2-11 to move downward, so that the sealing column 2-11 is inserted into the upper end opening of the semipermeable membrane fixture, and the corresponding work continues.

[0054] In the semipermeable membrane replacement mechanism provided in the specific embodiment of the present invention, the reagent driving structure is a peristaltic pump 2-12. The peristaltic pump 2-12 is composed of a stepper motor and a peristaltic pump head, and is mainly used to inject the sample and the cleaning liquid into the measuring chamber inside the semipermeable membrane fixing device. The peristaltic pump 2-12 has an adjustable speed and high precision, and has the advantages of high precision and low cross contamination.

[0055] Specifically, the flow control mechanism includes a clamping valve 2-13 and a sample adding handle 2-14, and a sample adding needle is arranged on the sample adding handle 2-14. The clamping valve 2-13 is a two-position three-way valve, and the three interfaces of the clamping valve 2-13 are respectively connected to the inside of the semipermeable membrane fixing device, the reagent pack and the external environment, and the sample adding handle 2-14 manually controls the working state of the peristaltic pump 2-12 and the clamping valve 2-13. The clamping valve 2-13 cooperates with the Y-type connector to realize the function of the two-position three-way valve, and one pipeline of the clamping valve 2-13 is connected to the inside of the semipermeable membrane fixing device 2-4, and the other two pipelines are respectively connected to the puncture needle 2-16 and the air. When connected to the puncture needle 2-16, it can be realized to suck out the cleaning liquid from the inside of the reagent pack to clean the measuring chamber of the semipermeable membrane fixing device; when connected to the air, the sample inside the sample adding needle can be sucked into the measuring chamber of the semipermeable membrane fixing device 2-4 to realize the sample adding function.

[0056] Preferably, the peristaltic pump 2-12, the pinch valve 2-13 and the sample adding handle 2-14 are located on the same side of the linear motor 2-4, and the pinch valve 2-13 and the sample adding handle 2-14 are located in front of the peristaltic pump 2-12. The installation position and connection mode of each component can also be adjusted according to the situation, all within the protection scope of the present invention.

[0057] On the basis of the semipermeable membrane replacement mechanism provided in the above-mentioned specific embodiments, a reagent pack is detachably mounted below the bottom plate 2-1, and the puncture needle 2-16 below the bottom plate 2-1 is inserted into the reagent pack, and the flow control mechanism is connected to the reagent pack through the puncture needle 2-16. The puncture needle 2-16 is fixed below the bottom plate 2-1, and mainly realizes the puncture of the sealing rubber plug of the reagent pack. When the puncture is successful, it can be connected with the reagent bag inside the reagent pack to realize the cleaning of the measurement chamber of the semipermeable membrane fixing device 2-4 and the recovery of the measurement waste liquid.

[0058] Preferably, a movable buckle 2-15 is provided below the bottom plate 2-1, and the movable buckle 2-15 is engaged with the upper end of the reagent pack, and the lower end of the screw rod 2-9 of the linear motor 2-4 can trigger the unlocking of the movable buckle 2-15 to eject the reagent pack. The linear motor 2-4 is a through-type linear motor, and the upper end of the linear motor 2-4 is connected to the transmission shaft 2-10. When the linear motor 2-4 moves upward, the screw rod 2-9 drives the transmission shaft 2-10 to move upward. When the linear motor 2-4 moves downward, the lower part of the screw rod 2-9 contacts the spring rod of the movable buckle 2-15, and the corresponding buckle of the reagent pack is linked with the spring rod and lifted to eject the reagent pack. The buckle torsion spring fits with the buckle through the buckle rotating shaft, so that the buckle is pressed downward to fix the reagent pack. A guide hook 2-17 matching the slideway at the upper end of the reagent pack is provided below the bottom plate 2-1, so as to play a guiding role in the process of replacing the reagent pack and prevent the problem of position displacement when the reagent pack is replaced.

[0059] When replacing the reagent pack, align the QR code on the reagent pack with the barcode scanner on the colloid osmotic pressure meter, input the information of the new reagent pack into the colloid osmotic pressure meter, and then install the new reagent pack into the colloid osmotic pressure meter. Place the reagent pack at the corresponding position inside the colloid osmotic pressure meter, and push the reagent pack into the colloid osmotic pressure meter with force. At this time, the linear motor 2-4 moves upward, and the active buckle 2-15 applies downward pressure under the action of the buckle torsion spring to lock the reagent pack, thereby completing the fixation of the reagent pack.

[0060] When it is necessary to add a sample, the sample adding handle 2-14 is lifted, and the sample is sucked under the power provided by the peristaltic pump 2-12, and the sample is present in the sample adding needle and the pipeline. After the sample adding handle 2-14 is put down, the clamping valve 2-13 is connected to the air, and the sample in the sample adding needle and the pipeline can be injected into the measuring chamber inside the semipermeable membrane fixing device; after the measurement is completed, the clamping valve 2-13 is switched to be connected to the reagent bag inside the reagent pack, and the measuring chamber inside the semipermeable membrane fixing device can be cleaned. After the cleaning is completed, the waste liquid in the measuring chamber of the semipermeable membrane fixing device is injected into the vacuum reagent belt inside the reagent pack to complete the recovery of the waste liquid.

[0061] Through the above method, automatic sample addition and cleaning are realized, the accurate sample addition amount is ensured, and the control accuracy is improved.

[0062] Please refer to Figures 5 to 9, Figure 5 is a schematic diagram of the internal structure of the semipermeable membrane fixing device in a specific embodiment of the colloid osmotic pressure measuring instrument provided by the present invention; Figure 6 is a schematic diagram of the external structure of the semipermeable membrane fixing device in a specific embodiment of the colloid osmotic pressure measuring instrument provided by the present invention; Figure 7 is a cross-sectional schematic diagram of the reference chamber container of the semipermeable membrane fixing device in a specific embodiment of the colloid osmotic pressure measuring instrument provided by the present invention; Figure 8 is a cross-sectional schematic diagram of the measuring chamber container of the semipermeable membrane fixing device in a specific embodiment of the colloid osmotic pressure measuring instrument provided by the present invention; Figure 9 is a top view of the supporting screen plate of the semipermeable membrane fixing device in a specific embodiment of the colloid osmotic pressure measuring instrument provided by the present invention.

[0063] The specific embodiment of the present invention provides a semipermeable membrane fixing device, including a reference chamber container 5-1 and a measuring chamber container 5-2, wherein the reference chamber container 5-1 is provided with a reference chamber, and the measuring chamber container 5-2 is provided with a measuring chamber 5-21 and a liquid pipeline connected to the measuring chamber 5-21, the reference chamber container 5-1 is installed below the measuring chamber container 5-2, and the upper end of the reference chamber is connected to the lower end of the measuring chamber 5-21, and a supporting sieve plate 5-3 is installed at the upper end of the reference chamber, and the supporting sieve plate 5-3 is covered with a semipermeable membrane 5-4, that is, the reference chamber container 5-1 and the measuring chamber container 5-2 are combined to form a fixture, and the reference chamber container 5-1 and the measuring chamber container 5-2 are provided with a cavity for detection work, and a semipermeable membrane 5-4 is installed in the cavity. The reference chamber container 5-1 and the measuring chamber container 5-2 are regarded as an integral part with the semipermeable membrane 5-4. When the semipermeable membrane 5-4 needs to be replaced, the fixture is replaced as a whole. Since the semipermeable membrane 5-4 is in a ready state in the fixture, no manual preparation is required, which greatly reduces human interference and reduces the failure rate. At the same time, a connection structure is provided on the periphery of the reference chamber container 5-1, and a detachable connection between the semipermeable membrane fixture and the reference chamber working hole at the corresponding position of the colloid osmotic pressure measuring instrument is realized through the connection structure. The replacement work can be completed by direct plugging and unplugging, which further improves the work efficiency.

[0064] Preferably, cylindrical protrusion structures can also be provided on both sides of the lower end of the measuring chamber container 5 - 2 , and inserted into corresponding positioning holes during installation to achieve installation guidance and positioning.

[0065] Preparation work before operation: first, drain the liquid inside the measuring cavity 5-21, tilt the semipermeable membrane fixture through the colloid osmotic pressure measuring instrument, and pull out the semipermeable membrane fixture that has reached the service life inside the colloid osmotic pressure measuring instrument. The next operation is to replace the new semipermeable membrane fixture. Tear off the film below the reference chamber container 5-1 of the new semipermeable membrane fixture, align the cylindrical protrusion structures on both sides below the semipermeable membrane fixture with the corresponding reference chamber working holes on the colloid osmotic pressure measuring instrument, and press down. When pressed to the bottom, the lower sealing ring below the reference chamber container 5-1 and the sensor fixture inside the colloid osmotic pressure measuring instrument are sealed. The switch inside the colloid osmotic pressure measuring instrument will be squeezed below the reference chamber container 5-1 to determine whether the new semipermeable membrane fixture is installed in place. After the new semipermeable membrane fixture is installed in place, it will be adjusted to a horizontal level. At this point, the new semipermeable membrane fixture is replaced and a new test can be performed.

[0066] The semipermeable membrane 5-4 and the installation container are combined into a whole to form a fixing device. When the semipermeable membrane 5-4 needs to be replaced, it is disassembled and installed together with the fixing device, which simplifies the installation process, reduces manual operations, reduces failure rates, and improves work efficiency.

[0067] Specifically, the reference chamber container 5 - 1 is a vertically arranged cylindrical structure, and a stepped through hole penetrating from top to bottom is arranged in the middle of the reference chamber container 5 - 1 to form a reference cavity. Furthermore, the stepped through hole is, from top to bottom, an upper sealing section 5-11, a sieve plate mounting section 5-12, an upper conical transition section 5-13, a middle section 5-14, a lower conical transition section 5-15 and a lower sealing section 5-16, wherein the diameters of the upper sealing section 5-11, the sieve plate mounting section 5-12, the upper conical transition section 5-13, the middle section 5-14 and the lower conical transition section 5-15 decrease in sequence, and the diameter of the lower sealing section 5-16 is larger than the diameter of the middle section 5-14. Through the above-mentioned size setting, the supporting sieve plate 5-3 is inserted into the sieve plate mounting section 5-12, the upper sealing ring 5-5 is installed in the upper sealing section 5-11 and presses the semipermeable membrane 5-4 and the supporting sieve plate 5-3, and the lower sealing ring is installed in the lower sealing section 5-16 for sealing and connecting the detection sensor.

[0068] The bottom of the reference chamber container 5-1 is in contact with the sensor to transmit the pressure change inside the measuring cavity 5-21. The reference cavity contains a reference solution. When there is colloidal osmotic pressure, it will exchange ions and small molecules with the sample. When equilibrium is reached, there will be a certain pressure in the reference cavity. The semipermeable membrane 5-4 is a thin film that is selective for the passage of different particles. It is a membrane structure that only allows ions and small molecules to pass freely. Biological macromolecules cannot pass freely through the semipermeable membrane. The reason is that the pore size of the semipermeable membrane is larger than that of ions and small molecules but smaller than biological macromolecules such as proteins and starch.

[0069] In order to ensure quick disassembly and connection, the connection structure is an annular groove 5-17 surrounding the outer periphery of the reference chamber container 5-1, and a matching annular protrusion is provided on the inner wall of the reference chamber working hole. The two are snap-fitted during installation. Of course, other connection and positioning methods can also be used, such as providing an axially extending guide groove, etc., which are all within the protection scope of the present invention. A plurality of positioning pits can also be provided on the bottom surface of the reference chamber container 1, and the plurality of positioning pits are provided around the reference cavity to achieve radial limiting after installation, and ensure that the sensor is smoothly inserted into the lower end of the reference cavity.

[0070] Further, a mounting hole 5-22 is provided at the lower end of the measuring chamber container 5-2, and the upper end of the reference chamber container 5-1 is inserted into the mounting hole 5-22. A straight hole penetrating from top to bottom is provided in the middle of the measuring chamber container 5-2 to form a measuring cavity 5-21. The measuring cavity 5-21 and the mounting hole 5-22 are arranged coaxially, and a connecting plate 5-7 for supporting the reference chamber container 5-1 is provided below the measuring chamber container 5-2. Specifically, a hole is provided in the middle of the connecting plate 5-7 for the lower end of the reference chamber container 5-1 to pass through, and a limiting step 5-18 is provided at a corresponding position on the outer periphery of the reference chamber container 5-1. After the connecting plate 5-7 is connected to the lower end of the measuring chamber container 5-2 by bolts or other means, the inner circle of the connecting plate 5-7 abuts against the limiting step 5-18 to achieve support and fixation of the reference chamber container 5-1. Of course, other connection methods can also be used, such as providing a buckle, or the upper end of the reference chamber container 5-1 is threadedly connected to the mounting hole 5-22, etc., which are all within the protection scope of the present invention.

[0071] In the semipermeable membrane fixing device provided by the specific embodiment of the present invention, a plurality of process holes 5-23 surrounding the measuring cavity 5-21 are arranged in the measuring chamber container 5-2, and the process holes 5-23 in multiple directions are interconnected to form a liquid pipeline, and the opening of the process hole 5-23 located on the outer surface of the measuring chamber container 5-2 is blocked by a plug 5-6. After the process hole 5-23 is connected, the upper end opening of the liquid pipeline is connected to the measuring cavity 5-21, and the lower end opening of the liquid pipeline is located at the lower end surface of the boss 5-24 at the lower end of the measuring chamber container 5-2. Further, a catheter 5-8 and a silicone tube 5-9 are installed in the lower end opening of the process hole 5-23.

[0072] On the basis of the semipermeable membrane fixing device provided in the above-mentioned specific embodiments, the supporting screen plate 5-3 is an arc-shaped plate that arches upward, and a plurality of screen holes 5-31 are arranged in an array on the supporting screen plate 5-3. Not only can the strength of the support be increased, but also the contact area between the semipermeable membrane 5-4 and the sample and the reference liquid is increased; the semipermeable membrane 5-4 is placed above the supporting screen plate 5-3 to block the protein in the sample and realize the measurement of the colloidal osmotic pressure; the measuring cavity 5-21 is installed above the reference cavity, and the measuring cavity 5-21 and the reference cavity are concentric through the shaft hole, and there is a convex structure below the measuring cavity 5-21 to squeeze the upper sealing ring 5-5 to achieve sealing. There are two bosses 5-24 below the measuring chamber container 5-2, and the catheter 5-8 and the silicone tube 5-9 are arranged in the boss 5-24. The catheter 5-8 is connected to the liquid pipeline inside the measuring chamber container 5-2 to realize the liquid inlet and outlet of the measuring cavity 5-21.

[0073] Please refer to Figures 10 to 15, Figure 10 is a schematic diagram of the structure of a reagent package in a specific embodiment of the colloid osmotic pressure measuring instrument provided by the present invention; Figure 11 is a schematic diagram of the decomposition of the reagent package in a specific embodiment of the colloid osmotic pressure measuring instrument provided by the present invention; Figure 12 is a schematic diagram of an upper cover of the reagent package in a specific embodiment of the colloid osmotic pressure measuring instrument provided by the present invention; Figure 13 is a side sectional view of the upper cover of the reagent package in a specific embodiment of the colloid osmotic pressure measuring instrument provided by the present invention; Figure 14 is a schematic diagram of the installation of a support plate of the reagent package in a specific embodiment of the colloid osmotic pressure measuring instrument provided by the present invention; Figure 15 is a schematic diagram of an upper view of the support plate of the reagent package in a specific embodiment of the colloid osmotic pressure measuring instrument provided by the present invention.

[0074] Please refer to Figures 16 and 17. Figure 16 is a schematic diagram of the internal structure of a specific implementation of the colloid osmotic pressure measuring instrument provided by the present invention; Figure 17 is a schematic diagram of the structure of the controller in a specific implementation of the colloid osmotic pressure measuring instrument provided by the present invention.

[0075] The specific embodiment of the present invention provides a colloid osmotic pressure determination reagent package, including a box body 6-1 and an upper cover 6-2. The box body 6-1 can be a box structure similar to a rectangular parallelepiped. Of course, other shapes, such as a cylindrical box, can also be used according to the situation. The lower end of the box body 6-1 is closed, and the upper end is open and provided with an opening. The upper cover 6-2 is buckled on the upper end opening of the box body 6-1 to form a closed cavity structure in the box body 6-1. A plurality of reagent bags 6-3 are installed in the box body 6-1. The reagent bags 6-3 are loaded with different reagents, such as different cleaning solutions, etc., and an empty reagent bag 6-3 can also be provided for collecting waste liquid. A plurality of delivery holes 6-4 are provided on the upper cover 6-2, and a sealing plug 6-5 is installed in each delivery hole 6-4. The rear end of the sealing plug 6-5 is connected to a delivery pipe 6-6, and each delivery pipe 6-6 is respectively connected to a plurality of reagent bags 6-3. A docking structure is provided on the upper end surface of the upper cover 6-2. Correspondingly, a corresponding docking structure is provided below the measuring instrument body 6-15, which is detachably connected to the upper cover 6-2. During use, the reagent pack is installed below the measuring instrument body. After the reagent is used up and there is no residue, the reagent pack can be removed and replaced with a new one. At the same time, a plurality of puncture needles are provided below the measuring instrument body. When the reagent pack is installed, the plurality of puncture needles pass through each sealing rubber plug 6-5 respectively, and each corresponding reagent bag 6-3 is connected through each delivery tube 6-6 to realize the delivery of cleaning liquid and fees. When cleaning is required, the cleaning liquid in the reagent bag 6-3 filled with cleaning liquid will be sucked out. When the test is completed, the waste liquid generated by the test will be discharged into the empty reagent bag 6-3, so that the waste liquid generated during the test will not overflow and will not contact the operator. Pollution to the environment and harm to the air are avoided.

[0076] Integrating multiple reagent bags 6-3 into one reagent package can provide cleaning liquid and collect waste liquid at the same time, simplifying the cleaning process, making the replacement process simple, shortening the cleaning time, realizing automatic cleaning, and improving work efficiency.

[0077] Specifically, it includes a cleaning liquid reagent bag and a vacuum reagent bag, wherein the cleaning liquid reagent bag contains cleaning liquid, and the vacuum reagent bag is an empty reagent bag, and the upper cover 6-2 is provided with two parallel delivery holes 6-4, two sealing rubber plugs 6-5 and two delivery tubes 6-6 respectively connect the cleaning liquid reagent bag and the vacuum reagent bag. The delivery tube 6-6 is a silicone tube, and of course other materials can also be used.

[0078] In order to prevent backflow, a one-way valve 6-7 is connected to the rear end of the sealing plug 6-5, and the rear end of the one-way valve 6-7 is connected to the front end of the delivery tube 6-6. The rear end of the delivery tube 6-6 is connected to the corresponding reagent bag 6-3. The flow directions of the one-way valves 6-7 at different positions are different. The one-way valve 6-7 connected to the cleaning liquid reagent bag allows the cleaning liquid to flow out of the cleaning liquid reagent bag to prevent backflow. The one-way valve 6-7 connected to the vacuum reagent bag allows the waste liquid to flow back to the vacuum reagent bag to prevent leakage.

[0079] In order to stably install the one-way valve 6-7, mounting seats 6-8 are respectively provided at both ends of the length direction of the lower end surface of the upper cover 6-2, and the two one-way valves 6-7 are respectively installed in the two mounting seats 6-8. The sealing rubber plug 6-5 is installed at the front end of the one-way valve 6-7, and the delivery hole 6-4 is provided at the front side rib of the upper cover 6-2. The sealing rubber plug 6-5 extends forward and is embedded in the delivery hole 6-4. Furthermore, a plurality of clamping claws 6-9 are provided on the lower end surface of the upper cover 6-2. The clamping claws 6-9 are provided behind the mounting seat 6-8. The clamping claws 6-9 clamp the middle part of the corresponding delivery pipe 6-6. The rear end of the delivery pipe 6-6 is bent downward to connect the cleaning liquid reagent bag and the vacuum reagent bag.

[0080] Specifically, the sealing rubber plug 6-5 is a cylindrical sleeve structure with a closed front end, that is, a mounting hole is provided at the rear end of the sealing rubber plug 6-5, and the front end of the one-way valve 6-7 extends into the mounting hole to achieve sealing with the one-way valve 6-7. At the same time, the outer periphery of the sealing rubber plug 6-5 and the inner wall of the delivery hole 6-4 are clamped by protrusions and grooves, so that the sealing rubber plug 6-5 and the delivery hole 6-4 are stably fixed and in close contact to ensure the sealing effect. Other fixing methods can also be used, such as setting a card slot, etc., which are all within the protection scope of the present invention.

[0081] In the colloidal osmotic pressure determination reagent package provided in a specific embodiment of the present invention, the docking structure includes a snap groove 6-10 arranged in the middle of the upper end surface of the upper cover 6-2 and guide grooves 6-11 arranged at both ends of the upper end surface of the upper cover 6-2 in the length direction. Corresponding snaps and hooks are arranged under the main body of the measuring instrument. During installation, the snaps cooperate with the snap grooves 6-10, and the hooks cooperate with the guide grooves 6-11 to achieve a detachable connection. At the same time, a guide groove 6-12 is arranged on the lower end surface of the box body 6-1, and a support plate is arranged under the main body of the measuring instrument. A space for placing the reagent package is arranged between the support plate and the main body of the measuring instrument. A guide rail is arranged on the support plate. During installation, the guide rail slides along the guide groove 6-12 to achieve guiding and limiting functions, wherein the guide groove 6-11 and the guide groove 6-12 both extend in the width direction.

[0082] Preferably, the baffles around the upper cover 6-2 wrap the upper end of the box body 6-1, and the two are connected by a buckle structure 6-13. Other connection methods can be used, such as bolt connection or interference fit, which are all within the protection scope of the present invention.

[0083] On the basis of the colloidal osmotic pressure determination reagent pack provided in the above specific embodiments, a support plate 6-14 is installed in the box body 6-1, and the shape of the support plate 6-14 matches the internal cross-sectional shape of the box body 6-1, and can be a square plate. The edges of the support plate 6-14 are in contact with the inner side wall of the support box body 6-1. A plurality of reinforcing ribs are arranged horizontally and vertically below the support plate 6-14 to improve the support strength. The two ends of the support plate 6-14 in the length direction are provided with process holes for the conveying pipe 6-6 to pass through. The function of supporting and protecting the box body 6-1 is achieved, and the damage and local deformation of the box body 6-1 caused by transportation and collision problems are avoided, and the reagents and waste liquids in the reagent pack are prevented from overflowing and polluting the environment and air.

[0084] Preparation before operation:

[0085] First, determine whether the reagent pack has reached its usage limit. When it reaches the limit, the colloid osmotic pressure meter will prompt you to replace the reagent pack. At this time, the reagent pack can be ejected automatically or manually, and then the ejected discarded reagent pack can be taken out; the next operation is to replace the new reagent pack.

[0086] Align the QR code on the new reagent pack with the barcode scanning gun on the colloid osmotic pressure measuring instrument, input the information of the new reagent pack into the colloid osmotic pressure measuring instrument, and then install the new reagent pack into the colloid osmotic pressure measuring instrument. Place the guide groove 12 below the box body 1 at the corresponding position inside the colloid osmotic pressure measuring instrument, and push the reagent pack into the colloid osmotic pressure measuring instrument with force. When the sound of the buckle being stuck is heard, the reagent pack is stuck, and the colloid osmotic pressure measuring instrument prompts that the installation is complete. At this point, the replacement of the new reagent pack is completed, and a new test can be performed. The present invention greatly shortens the replacement time, the replacement process is extremely simple, the failure rate is relatively low, and human operation is reduced to a greater extent.

[0087] Based on the colloidal osmotic pressure measuring instrument provided in the above-mentioned specific embodiments, it is characterized in that the body auxiliary module 3 includes a first diaphragm pump 3-1, a second diaphragm pump 3-2 and a gas-liquid separation bottle 3-3, the first diaphragm pump 3-1 is respectively connected to the inside of the semipermeable membrane fixing device 5 and the upper end of the gas-liquid separation bottle 3-3, mainly to inject the waste liquid in the measuring chamber inside the semipermeable membrane fixing device 5 into the gas-liquid separation bottle 3-3, that is, to complete the first step of waste liquid recovery, and the second diaphragm pump 3-2 is respectively connected to the lower end of the gas-liquid separation bottle 3-3 and the reagent pack 6. It mainly realizes injecting the separated waste liquid into the reagent bag 6-3 inside the reagent pack 6.

[0088] The body auxiliary module 3 also includes a filter, a network cable extension cable, a barcode scanner 3-4, a thermal printer 3-5 and a screen 3-6. The filter is used to filter out interference frequencies and provide stable voltage. The barcode scanner 3-4 is used to input information. The screen 3-6 is used to operate the software and display measurement results. The screen 3-6 is arranged above the housing 1, and the barcode scanner 3-4 and the thermal printer 3-5 are arranged in front of the housing 1. A window is arranged in front of the housing 1, and a door 3-7 is installed at the window. The semi-permeable membrane fixing device 5 can extend from the window.

[0089] The gas-liquid separation bottle 3-3 is a colorless and transparent plastic bottle. There are two connectors on the top of the bottle, which are used to connect the first diaphragm pump 3-1 and the filter respectively. There is a connector at the bottom of the bottle, which is used to connect with one end of the second diaphragm pump 3-2. There is a liquid level switch inside it to detect the liquid level height in the bottle. The filter is installed and fixed at the rear of the reagent pack 6, mainly to filter out the frequency with interference and provide a stable voltage, etc.; the network cable extension line is installed and fixed above the filter, and the other end is connected to the circuit board of the controller 4, mainly to realize the function of external network cable; the barcode scanner 3-4 is installed and fixed on the side of the compartment door 3-9, mainly to realize the replacement of the reagent pack 6, the semipermeable membrane 5-4 and the entry of patient information, etc.; the thermal printer 3-5 is installed and fixed below the barcode scanner 3-4, mainly to realize the printing function; the compartment door 3-9 includes an upper compartment door and a lower compartment door, the upper compartment door is installed above the lower compartment door, and when the semipermeable membrane fixing device 5 realizes the flipping function, the upper compartment door will move upward, mainly to realize the opening and closing functions when the semipermeable membrane 5-4 needs to be replaced; the screen 3-6 is installed on the top, mainly to realize the operation of the software and the display of the measurement results; the circuit board is installed and fixed below the screen 3-6, mainly to realize the input and output of the instructions of all components, etc. After the detection is completed, the test results will be analyzed, the final test results will be evaluated, and the results of the clinical diagnosis will be judged according to the actual measured experimental results.

[0090] When the sample loading handle 2-14 rotates upward, the sample loading needle fixing guide pushes the torsion spring paddle to rotate. When the sample loading handle 2-14 returns to its original position, the torsion spring pushes the sample loading needle fixing guide back to its original position. The sample loading needle is fixed inside the sample loading needle fixing guide by means of a snap buckle, mainly to fix the sample loading needle.

[0091] Preparation before operation:

[0092] First, turn on the fully automatic colloid osmotic pressure measuring instrument. After turning on, the fully automatic colloid osmotic pressure measuring instrument will perform an initialization and drainage action, mainly to empty the liquid in the internal pipeline of the fully automatic colloid osmotic pressure measuring instrument to prepare for the next test.

[0093] Add sample:

[0094] Click the Start Test button, and the fully automatic colloid osmotic pressure meter will remind you to lift the sample adding handle 2-14. You can lift the sample adding handle 2-14 according to the prompt and insert the sample adding needle into the prepared sample. The fully automatic colloid osmotic pressure meter will automatically suck the sample through the peristaltic pump. After the sample is sucked, put down the sample adding handle 2-14 according to the prompt. At this time, the sample adding process is completed.

[0095] The following actions are all completed automatically by the fully automatic colloid osmotic pressure tester.

[0096] Sample injection:

[0097] Since the reagent in the pipeline is injected into the measuring chamber of the semipermeable membrane fixing device during the above-mentioned sample suction process, the first diaphragm pump needs to be operated, and the liquid inside the measuring chamber of the semipermeable membrane fixing device is injected into the gas-liquid separation bottle, and then the sample needle and part of the sample in the pipeline are injected into the measuring chamber of the semipermeable membrane fixing device through the peristaltic pump, and the clamp valve is switched to inject the sample by sucking air at the same time. After the pressure stabilizes, the sample inside the measuring chamber of the semipermeable membrane fixing device is injected into the gas-liquid separation bottle through the first diaphragm pump; then the peristaltic pump is operated again to inject the remaining sample into the measuring chamber of the semipermeable membrane fixing device, and another measurement is performed. When the pressure stabilizes, the measurement of the colloid osmotic pressure is completed.

[0098] Cleaning the semipermeable membrane:

[0099] After the measurement is completed, the semipermeable membrane inside the semipermeable membrane fixture needs to be cleaned. For the first cleaning, the cleaning liquid inside the reagent pack is injected into the measuring chamber of the semipermeable membrane fixture through the operation of the peristaltic pump. At this time, the clamp valve is connected to the reagent bag inside the reagent pack through the puncture needle, and then the waste liquid inside the measuring chamber of the semipermeable membrane fixture is injected into the gas-liquid separation bottle through the first diaphragm pump. The above actions are completed three times in total. After three times, the cleaning action is completed. At this time, the entire test process is completed. When the waste liquid in the gas-liquid separation bottle reaches the corresponding height, the waste liquid in the gas-liquid separation bottle is sucked into the interior of the reagent pack through the second diaphragm pump to complete the recovery of the waste liquid.

[0100] The result is printed:

[0101] After the test is completed, the test results will be analyzed and the final test results will be evaluated. The results of the clinical diagnosis will be judged based on the actual measured experimental results. The results of the clinical diagnosis will be transmitted to the thermal printer and a paper report will be printed for clinical diagnosis.

[0102] To replace the reagent pack:

[0103] First, click the button to change the reagent pack. The linear motor moves downward, and the linear lead screw of the linear motor contacts the buckle spring rod, so that the reagent pack buckle moves upward under the action of the spring rod. At this time, the reagent pack buckle is separated from the buckle slot on the reagent pack cover, and the reagent pack pops out. Align the QR code of the new reagent pack with the scanner to enter the information. After successful entry, push the new reagent pack into the corresponding position in the body module. The reagent pack is replaced.

[0104] Replace the semipermeable membrane:

[0105] First, click the button to replace the semipermeable membrane. The linear motor will move upward, driving the rotating shaft and the connecting rod to move. At the same time, the upper plate supporting the measuring chamber will flip upward, and the upper plate supporting the measuring chamber will push the upper door upward. The other end of the connecting rod is hinged to the bottom of the semipermeable membrane fixture. Under the linkage of the connecting rod, the semipermeable membrane fixture will realize the flipping function, driving the lower door to flip downward, so that the upper and lower doors can be opened, and the semipermeable membrane fixture can be replaced. Then manually pull out the semipermeable membrane fixture, scan the code of the new semipermeable membrane fixture, enter it, and then insert it back to the corresponding position. Click to close the door to complete the replacement of the semipermeable membrane.

[0106] The above is a detailed introduction to the colloid osmotic pressure measuring instrument provided by the present invention. Specific examples are used herein to illustrate the principles and implementation methods of the present invention. The description of the above embodiments is only used to help understand the method of the present invention and its core idea. It should be pointed out that for ordinary technicians in this technical field, without departing from the principle of the present invention, the present invention can also be improved and modified in a number of ways, and these improvements and modifications also fall within the scope of protection of the claims of the present invention.

Claims

1. A colloid osmotic pressure measuring instrument, characterized in that: The invention comprises a shell (1), a semipermeable membrane replacement mechanism (2), a body auxiliary module (3) and a controller (4) installed in the shell (1); the semipermeable membrane replacement mechanism (2) is detachably connected to a semipermeable membrane fixing device (5) and a reagent pack (6); a semipermeable membrane (5-4) is arranged in the semipermeable membrane fixing device (5); the controller (4) is communicatively connected to the semipermeable membrane replacement mechanism (2) and the body auxiliary module (3); the body auxiliary module (3) is used for information input and output, controls the semipermeable membrane replacement mechanism (2) to drive the semipermeable membrane fixing device (5) and the reagent pack (6) to be automatically ejected, and adds a sample to the semipermeable membrane fixing device (5) to measure the osmotic pressure.

2. The colloid osmotic pressure measuring instrument according to claim 1, characterized in that: The semipermeable membrane replacement mechanism (2) comprises a bottom plate (2-1) and a mounting platform (2-2) mounted above the bottom plate (2-1), a reagent driving structure, a flow control mechanism, a replacement driving mechanism and a transmission mechanism; the semipermeable membrane fixing device (5) is detachably mounted on the mounting platform (2-2); a conveying mechanism connected to the interior of the semipermeable membrane fixing device (5) is arranged below the mounting platform (2-2); the reagent driving structure is connected to the conveying mechanism via the flow control mechanism and is used to allow different reagents to be input into or discharged from the interior of the semipermeable membrane fixing device (5); the replacement driving mechanism is connected to the mounting platform (2-2) via the transmission mechanism and is used to drive the mounting platform (2-2) to flip forward so that the upper end of the semipermeable membrane fixing device (5) tilts forward, or to drive the mounting platform (2-2) to flip backward so that the semipermeable membrane fixing device (5) returns to a vertical state.

3. The colloid osmotic pressure measuring instrument according to claim 2, characterized in that: The replacement drive mechanism is a vertically arranged linear motor (2-4); the transmission mechanism comprises a base (2-5), a transmission plate (2-6) and a connecting rod (2-7); the mounting platform (2-2) is located at the front end of the base plate (2-1); the base (2-5) is located at the rear end of the base plate (2-1); the mounting platform (2-2) is hinged to the base plate (2-1); the rear end of the transmission plate (2-6) is hinged to the base (2-5); a slide groove (2-8) is provided on the lower surface of the middle part of the transmission plate (2-6); the upper end of the lead screw (2-9) of the linear motor (2-4) is connected to a transmission shaft (2-10); the transmission shaft (2-10) is installed in the slide groove (2-8); the upper end of the connecting rod (2-7) is hinged to the front end of the transmission plate (2-6); and the lower end of the connecting rod (2-7) is hinged to the rear end of the mounting platform (2-2).

4. The colloid osmotic pressure measuring instrument according to claim 3, characterized in that: The reagent pack (6) is detachably mounted below the bottom plate (2-1); a puncture needle (2-16) below the bottom plate (2-1) is inserted into the reagent pack; the flow control mechanism is connected to the reagent pack via the puncture needle (2-16); an active buckle (2-15) is provided below the bottom plate (2-1); the active buckle (2-15) is engaged with the upper end of the reagent pack; the lower end of the lead screw (2-9) of the linear motor (2-4) can trigger the active buckle (2-15) to unlock, so as to eject the reagent pack (6).

5. The colloid osmotic pressure measuring instrument according to claim 1, characterized in that: The semipermeable membrane fixing device (5) comprises a reference chamber container (5-1) and a measuring chamber container (5-2); the reference chamber container (5-1) is provided with a reference chamber; the measuring chamber container (5-2) is provided with a measuring chamber (5-21) and a liquid pipeline communicating with the measuring chamber (5-21); the reference chamber container (5-1) is installed below the measuring chamber container (5-2); the upper end of the reference chamber is communicated with the lower end of the measuring chamber (5-21); a supporting sieve plate (5-3) is installed at the upper end of the reference chamber; the supporting sieve plate (5-3) is covered with a semipermeable membrane (5-4); and a connecting structure for detachably connecting to a reference chamber working hole of a colloid osmotic pressure measuring instrument is provided on the outer periphery of the reference chamber container (5-1).

6. The colloid osmotic pressure measuring instrument according to claim 1, characterized in that: The reagent pack (6) comprises a box body (6-1) and an upper cover (6-2) buckled on the upper opening of the box body (6-1); a plurality of reagent bags (3) are installed in the box body (6-1); a plurality of delivery holes (6-4) are provided on the upper cover (6-2); a sealing rubber plug (6-5) is installed in each of the delivery holes (6-4); a delivery tube (6-6) is connected to the rear end of the sealing rubber plug (6-5); each of the delivery tubes (6-6) is respectively connected to a plurality of the reagent bags (6-3); a docking structure for detachably connecting to a measuring instrument body is provided on the upper end surface of the upper cover (6-2); during installation, a plurality of puncture needles below the measuring instrument body respectively penetrate through each of the sealing rubber plugs (6-5) to conduct the corresponding reagent bags (6-3).

7. The colloid osmotic pressure measuring instrument according to claim 6, characterized in that: The docking structure comprises a buckle groove (6-10) arranged in the middle of the upper end surface of the upper cover (6-2) and guide grooves (6-11) arranged at both ends of the upper end surface of the upper cover (6-2) in the length direction, and a guide groove (6-12) is arranged on the lower end surface of the box body (6-1), and the buckle groove (6-10), the guide groove (6-11) and the guide groove (6-12) all extend in the width direction.

8. The colloid osmotic pressure measuring instrument according to any one of claims 1 to 7, characterized in that: The body auxiliary module (3) comprises a first diaphragm pump (3-1), a second diaphragm pump (3-2) and a gas-liquid separation bottle (3-3), wherein the first diaphragm pump (3-1) is respectively connected to the interior of a semipermeable membrane fixing device (5) and the upper end of the gas-liquid separation bottle (3-3), and the second diaphragm pump (3-2) is respectively connected to the lower end of the gas-liquid separation bottle (3-3) and the reagent pack (6).

9. The colloid osmotic pressure measuring instrument according to claim 8, characterized in that: The machine body auxiliary module also includes a filter, a network cable extension cable, a barcode scanner (3-4), a thermal printer (3-5) and a screen (3-6), wherein the filter is used to filter out interference frequencies and provide a stable voltage, the barcode scanner (3-4) is used to input information, and the screen (3-6) is used to operate software and display measurement results.

10. The colloid osmotic pressure measuring instrument according to claim 9, characterized in that: The screen (3-6) is arranged above the shell (1), the barcode scanner (3-4) and the thermal printer (3-5) are arranged in front of the shell (1), a window is arranged in front of the shell (1), a door (3-7) is installed at the window, and the semi-permeable membrane fixing device (5) can extend from the window.

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