Preparation method of PEDOT electrode, PEDOT electrode and sensing device

Abstract

The invention provides a preparation method of a PEDOT electrode, the PEDOT electrode and a sensing device for virus detection, and relates to the technical field of electrochemical biosensors. The preparation method of the PEDOT electrode comprises the following steps: preparing a first silk-screen printing carbon electrode; anchoring ferric ions on the surface of the first screen-printed carbon electrode to form a second screen-printed carbon electrode; and placing the second screen-printed carbon electrode and the EDOT monomer in a closed container, and heating the closed container to obtain the first PEDOT electrode. According to the invention, the high-conductivity PEDOT electrode can be prepared on a large scale.

Description

Technical Field

[0001] The present disclosure relates to the technical field of electrochemical biosensors, and in particular to a method for preparing a PEDOT electrode, a PEDOT electrode, and a sensor device for virus detection. Background Art

[0002] The increasing demand for rapid disease diagnosis and continuous monitoring has driven the rapid development of electrochemical biosensors. However, there are few types of nanomaterials currently used to construct sensing electrodes, and the preparation process is usually complex and time-consuming, with high technical difficulty, which may lead to poor electrochemical performance and reproducibility. Therefore, it is still an urgent need to develop a preparation strategy for large-scale production of high-performance functionalized nanoelectrodes.

[0003] Poly(3,4-ethylenedioxythiophene) monomer (PEDOT) is widely used in organic thin-film solar cells, electrochemical energy storage, sensor electrode materials and other fields due to its unique physical, chemical and good biocompatibility. During use, PEDOT:PSS (polystyrene sulfonic acid) suspension is usually directly mixed with electrode materials with poor conductivity, or EDOT monomer is in situ polymerized into PEDOT by chemical or electrochemical methods.

[0004] However, PSS is insulated, electrochemical polymerization often requires a conductive substrate, and chemical polymerization often presents agglomerated particles and template removal is complicated. Currently, there is still a lack of PEDOT electrode preparation methods that can be prepared on a large scale and have low preparation complexity.

[0005] It should be noted that the information disclosed in the above background technology section is only used to enhance the understanding of the background of the present disclosure, and therefore may include information that does not constitute the prior art known to ordinary technicians in the field. Summary of the invention

[0006] The purpose of the present disclosure is to provide a method for preparing a PEDOT electrode, a PEDOT electrode and a sensor device for virus detection, thereby overcoming the problem that PEDOT electrodes cannot be prepared on a large scale and the preparation process is complicated, at least to a certain extent.

[0007] According to a first aspect of the present disclosure, a method for preparing a PEDOT electrode is provided, comprising: preparing a first screen-printed carbon electrode; anchoring trivalent iron ions on the surface of the first screen-printed carbon electrode to form a second screen-printed carbon electrode; placing the second screen-printed carbon electrode and an EDOT monomer in a sealed container, and heating the sealed container to obtain a first PEDOT electrode.

[0008] Optionally, preparing the first screen-printed carbon electrode includes: using a PET film as a supporting substrate and preparing a first intermediate electrode by screen printing; and obtaining a first screen-printed carbon electrode based on the first intermediate electrode.

[0009] Optionally, obtaining the first screen-printed carbon electrode based on the first intermediate electrode includes: soaking the first intermediate electrode in a sodium hydroxide solution to obtain a second intermediate electrode; and treating the second intermediate electrode in an oxygen plasma cleaning machine to obtain the first screen-printed carbon electrode.

[0010] Optionally, anchoring trivalent iron ions on the surface of the first screen-printed carbon electrode to form a second screen-printed carbon electrode comprises: drop-coating an aqueous solution of ferric chloride on the surface of the first screen-printed carbon electrode, and obtaining the second screen-printed carbon electrode after drying.

[0011] Optionally, the second screen-printed carbon electrode and the EDOT monomer are placed in a sealed container, and the sealed container is heated to obtain a first PEDOT electrode, including: placing the second screen-printed carbon electrode in a sealed container; placing the EDOT monomer in an open container; placing the sealed container and the open container in a sealed container; placing the sealed container in an oven, and after heating treatment in the oven, taking out the sealed container to obtain the first PEDOT electrode.

[0012] Optionally, taking out the sealed container to obtain the first PEDOT electrode includes: taking out the sealed container and taking out the third intermediate electrode from the sealed container; treating the third intermediate electrode with a hydrochloric acid solution to obtain a fourth intermediate electrode; and rinsing the fourth intermediate electrode with ultrapure water to obtain the first PEDOT electrode.

[0013] Optionally, the method for preparing the PEDOT electrode further includes: using chloroauric acid as an electrolyte to deposit gold nanoparticles on the first PEDOT electrode to obtain a second PEDOT electrode.

[0014] Optionally, the method for preparing the PEDOT electrode further comprises: amminating the surface of the second PEDOT electrode with mercaptoethylamine to obtain a third PEDOT electrode.

[0015] According to a second aspect of the present disclosure, a PEDOT electrode is provided, which is prepared using any of the above-mentioned methods for preparing a PEDOT electrode.

[0016] According to a third aspect of the present disclosure, a sensor device for virus detection is provided, which is prepared using the above-mentioned PEDOT electrode.

[0017] In the exemplary embodiments of the present disclosure, on the one hand, the PEDOT electrode is obtained by heating reaction, which can realize the preparation process of the PEDOT electrode with high conductivity and large scale. On the other hand, the present disclosure anchors the trivalent iron ions on the surface of the screen-printed carbon electrode, thereby forming an initiator for the polymerization of EDOT monomers, which can promote the formation of PEDOT nanofiber bundle electrodes. On the other hand, the process of the present disclosure is easy to implement.

[0018] It is to be understood that the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the present disclosure. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] The accompanying drawings herein are incorporated into the specification and constitute a part of the specification, illustrate embodiments consistent with the present disclosure, and together with the specification are used to explain the principles of the present disclosure. Obviously, the accompanying drawings described below are only some embodiments of the present disclosure, and for ordinary technicians in this field, other accompanying drawings can be obtained based on these accompanying drawings without creative work.

[0020] Figure 1 A flow chart of a method for preparing a PEDOT electrode according to an exemplary embodiment of the present disclosure is schematically shown.

[0021] Figure 2 A scanning electron microscope (SEM) image of the first PEDOT electrode of an embodiment of the present disclosure at a low magnification is schematically shown.

[0022] Figure 3 The SEM image of the first PEDOT electrode of the embodiment of the present disclosure at a high magnification is schematically shown.

[0023] Figure 4 The SEM image of the second PEDOT electrode according to the embodiment of the present disclosure is schematically shown.

[0024] Figure 5 A schematic diagram of Differential Pulse Voltammetry (DPV) curves of a first screen-printed carbon electrode, a first PEDOT electrode, and a second PEDOT electrode according to an embodiment of the present disclosure is shown.

[0025] Figure 6 A schematic diagram showing a cyclic voltammetry (CV) curve of a third PEDOT electrode according to an embodiment of the present disclosure is shown.

[0026] Figure 7The linear relationship curve between the scan rate and the peak current of the third PEDOT electrode of the embodiment of the present disclosure is schematically shown.

[0027] Figure 8 A schematic diagram of the DPV curve of the sensor device based on the third PEDOT electrode for detecting the new coronavirus according to an embodiment of the present disclosure is shown.

[0028] Fig. 9 The linear relationship curve between the novel coronavirus antigen concentration and the peak current difference of the embodiment of the present disclosure is schematically shown. DETAILED DESCRIPTION

[0029] Example embodiments will now be described more fully with reference to the accompanying drawings. However, example embodiments can be implemented in a variety of forms and should not be construed as being limited to the examples set forth herein; on the contrary, these embodiments are provided so that the present disclosure will be more comprehensive and complete, and the concepts of the example embodiments are fully conveyed to those skilled in the art. The described features, structures, or characteristics may be combined in any suitable manner in one or more embodiments. In the following description, many specific details are provided to provide a full understanding of the embodiments of the present disclosure. However, those skilled in the art will appreciate that the technical solutions of the present disclosure may be practiced while omitting one or more of the specific details, or other methods, processes, steps, etc. may be adopted. In other cases, known technical solutions are not shown or described in detail to avoid obscuring various aspects of the present disclosure.

[0030] In addition, the accompanying drawings are only schematic illustrations of the present disclosure and are not necessarily drawn to scale. The same reference numerals in the figures represent the same or similar parts, and thus their repeated descriptions will be omitted. The flowcharts shown in the accompanying drawings are only exemplary illustrations and do not necessarily include all the steps. For example, some steps can also be decomposed, while some steps can be combined or partially combined, so the actual execution order may change according to actual conditions. In addition, all the terms "first", "second", "third", etc. below are only for the purpose of distinction and should not be used as limitations of the present disclosure.

[0031] Figure 1 The flowchart of the method for preparing a PEDOT electrode according to an exemplary embodiment of the present disclosure is schematically shown. Figure 1 The method for preparing the PEDOT electrode according to the embodiment of the present disclosure comprises the following steps:

[0032] S12. Prepare a first screen-printed carbon electrode.

[0033] In an exemplary embodiment of the present disclosure, a PET film is used as a supporting substrate, and after surface cleaning, a first intermediate electrode is prepared by screen printing. Specifically, as a working electrode, the first intermediate electrode is a carbon screen printed electrode (SPC). In addition, a carbon counter electrode and a silver reference electrode can also be prepared based on the same method.

[0034] Next, a first screen-printed carbon electrode may be obtained based on the first intermediate electrode.

[0035] According to some embodiments of the present disclosure, the first intermediate electrode may be used as a first screen-printed carbon electrode.

[0036] According to some other embodiments of the present disclosure, the first intermediate electrode may be soaked in a sodium hydroxide solution to obtain a second intermediate electrode, and then treated with an oxygen plasma cleaning machine to obtain a first screen-printed carbon electrode.

[0037] Specifically, the first intermediate electrode can be immersed in a 1M sodium hydroxide solution for 30 minutes to obtain the second intermediate electrode. For the oxygen plasma cleaning machine, the oxygen flow rate can be set to 10-60 SCCM, and the oxygen plasma treatment time can be set to 1-20 minutes.

[0038] On the one hand, the excess organic solvent and grease on the first intermediate electrode can be removed by soaking in sodium hydroxide solution, and on the other hand, the active sites can be increased and the hydrophilicity can be improved by further treatment in an oxygen plasma cleaning machine.

[0039] S14. Anchoring trivalent iron ions on the surface of the first screen-printed carbon electrode to form a second screen-printed carbon electrode.

[0040] According to some embodiments of the present disclosure, 1-60 mM Fe 3+ Anchoring on the surface of the first screen-printed carbon electrode prepared in step S12 to obtain a second screen-printed carbon electrode.

[0041] The anchoring addition of trivalent iron ions can serve as an initiator for the subsequent polymerization of EDOT monomers.

[0042] For example, an aqueous solution of ferric chloride can be dripped onto the surface of the first screen-printed carbon electrode, and then dried to obtain a second screen-printed carbon electrode. 3+ The concentration can be configured to be 10-30mM.

[0043] S16. Place the second screen-printed carbon electrode and the EDOT monomer in a sealed container, and heat the sealed container to obtain a first PEDOT electrode.

[0044] On the one hand, the second screen-printed carbon electrode obtained in step S14 can be placed in a sealed container, wherein the sealed container is a reactor, specifically, a sealed container such as a glass jar, a reactor, etc. On the other hand, the EDOT monomer is placed in an open container, such as a beaker, and the material of the open container can be glass, polytetrafluoroethylene, etc. The amount of EDOT can be 1-100 μL, such as 5 μL, 50 μL, etc.

[0045] In this case, the second screen-printed carbon electrode and the open container containing the EDOT monomer can be placed in a sealed container, wherein the capacity of the sealed container is, for example, 500-1000 mL.

[0046] Next, the sealed container can be placed in an oven, and after being heated in the oven, the sealed container can be taken out to obtain a first PEDOT electrode, wherein the oven temperature can be set to 80-200° C., for example, 90° C., 140° C., etc., and the heating time can be set to 1-90 min, for example, 60 min.

[0047] Specifically, the sealed container is taken out from the oven, and then the third intermediate electrode is taken out from the sealed container. The third intermediate electrode is treated with a 0.1-3M hydrochloric acid solution to obtain a fourth intermediate electrode. The fourth intermediate electrode is then rinsed with ultrapure water to obtain a first PEDOT electrode. In the solution of the embodiment of the present disclosure, the first PEDOT electrode can also be referred to as an SPC / PEDOT electrode or an SPC / PEDOT nanofiber bundle electrode.

[0048] The excess trivalent iron ions can be effectively removed by treating with hydrochloric acid solution. The electrode can be neutralized by rinsing with ultrapure water to ensure normal function of the electrode.

[0049] After obtaining the first PEDOT electrode, the first PEDOT electrode can be used as a substrate and a chloroauric acid aqueous solution can be used as an electrolyte to deposit gold nanoparticles (AuNPs) on the first PEDOT electrode by cyclic voltammetry through a three-electrode system to obtain a second PEDOT electrode. The second PEDOT electrode can also be called a SPC / PEDOT / AuNPs electrode.

[0050] After obtaining the second PEDOT electrode, the surface of the second PEDOT electrode can be aminated with mercaptoethylamine to obtain a third PEDOT electrode, which can also be called a SPC / PEDOT / AuNPs-NH2 electrode.

[0051] In addition, for the third PEDOT electrode, a sensor device for virus detection can be obtained by activating the amino group with glutaraldehyde (GA), covalently fixing the virus antibody, and blocking the redundant active sites.

[0052] Compared with the traditional sensing platform electrode preparation method, the disclosed solution has the advantages of high conductivity and large-scale preparation. The disclosed solution can control the morphology of the first PEDOT electrode (SPC / PEDOT) obtained by controlling the initiator concentration, EDOT monomer concentration and the time of gas phase polymerization, and further by electrodeposition of AuNPs, utilize the characteristics of S in the PEDOT molecular structure, which can combine with Au to form Au-S bonds, thereby forming a SPC / PEDOT / AuNPs composite sensing electrode, further improving the electrode conductivity and biocompatibility. In addition, by functionalizing the amino groups of SPC / PEDOT / AuNPs with mercaptoethylamine, and further using glutaraldehyde to perform Schiff base reaction, an electrochemical biosensor is constructed. In a 5mM potassium ferrocyanide electrolyte, for example, the SPC / PEDOT / AuNPs-NH2-based sensor constructed by the disclosed solution exhibits a lower detection limit and higher sensitivity to viruses (such as SARS-CoV-2).

[0053] The preparation process of the PEDOT electrode disclosed in the present invention is described below through examples.

[0054] First, a PET film was used as a supporting substrate. After the surface was cleaned, a working electrode, a counter electrode and a reference electrode were prepared by screen printing. Among them, the working electrode, the counter electrode and the reference electrode were carbon, carbon and silver electrodes, respectively. The working electrode was soaked in a 1M sodium hydroxide solution for 30 minutes to remove excess organic solvents and grease, and then rinsed with ultrapure water and placed in an oven at 60°C for drying. The dried working electrode was further treated with an oxygen plasma cleaner for 15 minutes to improve the hydrophilicity of the electrode surface. Thus, the above-mentioned first screen-printed carbon electrode was obtained.

[0055] Next, 6.4 μL of ferric chloride aqueous solution (66.5 mM) can be dripped onto the surface of the first screen-printed carbon electrode, and after natural drying, it can be transferred to a 750 mL reactor. After placing an open container containing 25 μL of EDOT monomer in the reactor, the reactor is sealed. The sealed reactor is placed in an oven, heated to 120°C and maintained for 3 minutes. After the temperature drops to room temperature, the reactor is taken out, opened in a fume hood, and the electrode is taken out.

[0056] Then, 10 μL of 1M hydrochloric acid solution was dripped on the electrode taken out of the reactor, and the hydrochloric acid solution was replaced after immersion for 30 minutes to remove excess trivalent iron ions. The electrode soaked in hydrochloric acid was rinsed with ultrapure water until neutral, and then dried with nitrogen to obtain the first PEDOT electrode.

[0057] refer to Figure 2 and Figure 3 The nanofiber bundles composed of PEDOT nanofibers grow vertically and cross-grown on the surface of the screen-printed carbon electrode. The length of the nanofiber bundles is about 1-2 μm and the diameter is about 200 nm. The bottom of the fiber bundles presents a three-dimensional porous cross-linked network structure.

[0058] In addition, the first PEDOT electrode can be used as a substrate, chloroauric acid can be used as an electrolyte, and Au nanoparticles can be electrodeposited by cyclic voltammetry through a three-electrode system to obtain the second PEDOT electrode through the combination of S-Au bonds. Figure 4 , Au nanoparticle clusters can be evenly distributed at the tip and bottom of the nanofiber bundle.

[0059] Figure 5 A schematic diagram showing DPV curves of a first screen-printed carbon electrode, a first PEDOT electrode, and a second PEDOT electrode according to an embodiment of the present disclosure is shown.

[0060] refer to Figure 5 On the one hand, compared with the first screen-printed carbon electrode, the peak current of the first PEDOT electrode increased significantly, indicating that the current of the SPC / PEDOT nanofiber bundle electrode increased significantly compared with the screen-printed carbon electrode. Therefore, this composite structure design is conducive to the rapid transmission of electrolyte ions inside the electrode, and also provides a conductive path for the transmission of electrons at the interface between the electrode and the substrate, thereby providing a fast reaction kinetic site for the subsequent electrochemical reaction. On the other hand, the peak current of the second PEDOT electrode increased further significantly, indicating that the introduction of Au nanoparticles can further improve the conductivity of the composite electrode. This structure can provide sufficient active sites and a fast ion / electron kinetic basis for the fixation of the subsequent biological probe.

[0061] After obtaining the above-mentioned second PEDOT electrode, 15 μL of a 100 mM mercaptoethylamine aqueous solution can be drop-coated on the surface of the second PEDOT electrode, and then incubated in a 37°C incubator for 2 hours, rinsed with ultrapure water to remove unbonded mercaptoethylamine, and then blown dry with nitrogen to obtain an amino-functionalized SPC / PEDOT / AuNPs-NH2 electrode, that is, the above-mentioned third PEDOT electrode is obtained.

[0062] The electrochemical performance of the third PEDOT electrode was characterized by cyclic voltammetry in 5 mM potassium ferrocyanide electrolyte. Figure 6 , at 20-1000mV s -1 At scan rates within a certain range, the third PEDOT electrode showed obvious redox peak pairs, and the redox potential changed slightly when the scan rate changed.

[0063] The peak current and scan rate were further fitted, referring to Figure 7 , the peak current is linearly related to the scan rate. Specifically, for the anode peak current, the fitted linear relationship is I pa =0.38619+0.00282v, R 2 =0.984; for the cathode peak current, the fitted linear relationship is I pc =-0.42238-0.00264v, R 2 =0.977. The slopes of the two electrodes are similar in value, indicating that the redox process of the third PEDOT electrode is a quasi-reversible surface-controlled process, even at 1000 mV s -1 It can still maintain a high reversibility at a high scan rate, which provides a fast ion / electron dynamics basis for the sensor device during electrochemical detection, thereby achieving a high sensitivity.

[0064] In addition, a sensor device for virus detection can be further constructed using the third PEDOT electrode.

[0065] Taking the detection of SARS-CoV-2 virus as an example, 15 μL of 2.5% glutaraldehyde (GA) can be dropped on the surface of the third PEDOT electrode and sealed. Incubate in a 37°C incubator for 1 hour and rinse with ultrapure water to remove excess unbonded aldehyde groups. After drying with nitrogen, drop 10 μg mL -1 10 μL of sars-cov-2 antibody was added and incubated in a 37°C incubator for 1.5 hours, and the excess sars-cov-2 antibody was removed by rinsing. Then, 10 μL of 2.5% ethanolamine was used to quench the excess aldehyde group. Next, 10 μL of 1% bovine serum albumin was used to further block the non-covalently bound active sites, and a sensor device that can respond to different concentrations of antigens was obtained.

[0066] Figure 8 The DPV curves at different COVID-19 antigen concentrations are shown as an example. Fig. 9 Shown based on Figure 8 The fitting results of the data. Figure 8 and Fig. 9 The peak current difference is related to the antigen concentration in the range of 1-100 ng mL -1 The relationship is linear within the antigen concentration range. Specifically, the fitted linear relationship is y=0.04986+0.17717x, R 2=0.94526. In addition, according to calculation, the detection limit of the above-mentioned sensor device of the present disclosure is 0.068ng mL -1 , sensitivity is 0.902mA·ng·mL -1 cm -2 .

[0067] Furthermore, the disclosed embodiment also provides a PEDOT electrode, which is prepared using the above-mentioned method for preparing the PEDOT electrode.

[0068] Furthermore, the embodiments of the present disclosure also provide a sensor device for virus detection, which is prepared using the above-mentioned PEDOT electrode.

[0069] It should be noted that although the steps of the method in the present disclosure are described in a specific order in the drawings, this does not require or imply that the steps must be performed in this specific order, or that all the steps shown must be performed to achieve the desired results. Additionally or alternatively, some steps may be omitted, multiple steps may be combined into one step, and / or one step may be decomposed into multiple steps, etc.

[0070] In addition, the above-mentioned figures are only schematic illustrations of the processes included in the method according to the exemplary embodiments of the present disclosure, and are not intended to be limiting. It is easy to understand that the processes shown in the above-mentioned figures do not indicate or limit the time sequence of these processes. In addition, it is also easy to understand that these processes can be performed synchronously or asynchronously, for example, in multiple modules.

[0071] Those skilled in the art will readily appreciate other embodiments of the present disclosure after considering the specification and practicing what is disclosed herein. This application is intended to cover any variations, uses, or adaptations of the present disclosure that follow the general principles of the present disclosure and include common knowledge or customary technical means in the art that are not disclosed in the present disclosure. The specification and embodiments are to be considered merely as exemplary, and the true scope and spirit of the present disclosure are indicated by the claims.

[0072] It should be understood that the present disclosure is not limited to the exact structures that have been described above and shown in the drawings, and that various modifications and changes may be made without departing from the scope thereof. The scope of the present disclosure is limited only by the appended claims.

Claims

1. A method for preparing a PEDOT electrode, characterized in that: include: preparing a first screen-printed carbon electrode; anchoring trivalent iron ions on the surface of the first screen-printed carbon electrode to form a second screen-printed carbon electrode; The second screen-printed carbon electrode and the EDOT monomer are placed in a sealed container, and the sealed container is heated to obtain a first PEDOT electrode.

2. The method for preparing a PEDOT electrode according to claim 1, characterized in that: Preparing a first screen-printed carbon electrode comprises: Using PET film as a supporting substrate, a first intermediate electrode is prepared by screen printing; A first screen-printed carbon electrode is obtained based on the first intermediate electrode.

3. The method for preparing a PEDOT electrode according to claim 2, characterized in that: Producing a first screen-printed carbon electrode based on the first intermediate electrode comprises: soaking the first intermediate electrode in a sodium hydroxide solution to obtain a second intermediate electrode; The second intermediate electrode is treated by an oxygen plasma cleaning machine to obtain a first screen-printed carbon electrode.

4. The method for preparing a PEDOT electrode according to claim 1, characterized in that: Anchoring trivalent iron ions on the surface of the first screen-printed carbon electrode to form a second screen-printed carbon electrode, comprising: The ferric chloride aqueous solution is drop-coated on the surface of the first screen-printed carbon electrode, and after drying, a second screen-printed carbon electrode is obtained.

5. The method for preparing a PEDOT electrode according to claim 1, characterized in that: Placing the second screen-printed carbon electrode and the EDOT monomer in a sealed container, and heating the sealed container to obtain a first PEDOT electrode, comprising: placing the second screen-printed carbon electrode in a sealed container; Place EDOT monomer in an open container; placing the open container in the closed container; The sealed container is placed in an oven, and after being heated in the oven, the sealed container is taken out to obtain a first PEDOT electrode.

6. The method for preparing a PEDOT electrode according to claim 5, characterized in that: The sealed container is taken out to obtain a first PEDOT electrode, comprising: Taking out the sealed container, and taking out the third intermediate electrode from the sealed container; Treating the third intermediate electrode with a hydrochloric acid solution to obtain a fourth intermediate electrode; The fourth intermediate electrode is rinsed with ultrapure water to obtain a first PEDOT electrode.

7. The method for preparing a PEDOT electrode according to any one of claims 1 to 6, characterized in that: The preparation method of the PEDOT electrode further comprises: Using chloroauric acid as an electrolyte, gold nanoparticles are deposited on the first PEDOT electrode to obtain a second PEDOT electrode.

8. The method for preparing a PEDOT electrode according to claim 7, characterized in that: The preparation method of the PEDOT electrode further comprises: The surface of the second PEDOT electrode is amino-treated with mercaptoethylamine to obtain a third PEDOT electrode.

9. A PEDOT electrode, characterized in that: The PEDOT electrode is prepared by the method for preparing the PEDOT electrode according to any one of claims 1 to 8.

10. A sensor device for virus detection, characterized in that: Prepared using the PEDOT electrode as claimed in claim 9.

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