A mixing device for preparing transdermal patch adhesive

Abstract

The invention relates to the technical field of mixing devices, in particular to a mixing device for preparing transdermal patch glue, comprising a supporting base, a mixing drum is arranged above the supporting base, a first feeding pipe is fixedly connected to the top of the mixing drum, a second feeding pipe is fixedly connected to the upper side of the mixing drum, a sealing plate is fixedly connected to the opening at the bottom of the mixing drum, the sealing plate is fixedly connected to the supporting base, and a heating and stirring mechanism and a sedimentation and lifting mechanism are connected to the sealing plate; the invention forms transdermal patch glue by mixing and dissolving with glue liquid through the action of the heating and stirring mechanism, and in the process of mixing and stirring, the transdermal patch glue is continuously tumbled upwards through the action of the sedimentation and lifting mechanism, thereby increasing the up and down flow of the transdermal patch glue, reducing the sedimentation of the transdermal patch glue to the bottom, and accelerating the dissolution of the transdermal patch glue.

Description

Technical Field

[0001] The invention relates to the technical field of mixing devices, in particular to a mixing device for preparing transdermal patch adhesive paste. Background Art

[0002] A transdermal patch is a drug dosage form that is attached to the skin and gradually releases the drug into the body through the absorption of the skin. When preparing a transdermal patch, a carrier, an adhesive and a penetration enhancer are heated and mixed to prepare an adhesive solution, and then the drug is added to the adhesive solution and stirred until dissolved to prepare a transdermal patch adhesive paste.

[0003] The patent document with announcement number CN118179332A discloses a mixing device for preparing transdermal patch adhesive, which includes a base plate, a device body is fixedly installed on the top of the base plate, a support platform is fixedly installed on the middle part of the upper part of the device body, a mounting platform is fixedly installed on one side of the upper part of the device body, a mixing cylinder is fixedly installed on the top of the support platform, a discharge valve is fixedly installed on the lower part of the surface of the mixing cylinder, a feed cylinder is fixedly installed on the top of the mounting platform, one end of the discharge valve is fixedly connected to the feed cylinder, and a feed pipe is fixedly installed on the upper part of the surface of the mixing cylinder.

[0004] In the current technology, when preparing transdermal patch adhesive, the transdermal patch adhesive is usually mixed and stirred. During the stirring process, the transdermal patch adhesive is prone to produce sediment and sink to the bottom, thereby affecting the uniformity of the transdermal patch adhesive. In addition, during the mixing process, it is difficult to effectively handle the solid impurities produced by the mixing, thereby reducing the finished product effect of the transdermal patch adhesive. Summary of the invention

[0005] The purpose of the present invention is to solve the shortcomings of the above-mentioned technology and to propose a mixing device for preparing transdermal patch paste.

[0006] To achieve the above purpose, the technical solution adopted by the present invention is: a mixing device for preparing transdermal patch adhesive paste, comprising a supporting base, a mixing cylinder is arranged above the supporting base, a first feed pipe is fixedly connected to the top of the mixing cylinder, a second feed pipe is fixedly connected to the top of the side of the mixing cylinder, a sealing plate is fixedly connected to the opening at the bottom of the mixing cylinder, the sealing plate is fixedly connected to the supporting base, and a heating and stirring mechanism and a precipitation and rising mechanism are connected to the sealing plate;

[0007] The bottom of the sealing plate is fixedly connected with a discharge pipe, a first electrically controlled valve is fixedly mounted on the discharge pipe, four material receiving shells are circumferentially arranged above the support base, a support plate is fixedly connected to the inside of the material receiving shell, a plurality of filtrate holes are provided on the support plate, a filter membrane is fixedly connected to the top of the support plate, an intermittent rotating mechanism and a pressurized filtrate mechanism are connected to the material receiving shell, a flipping and cleaning mechanism and a drying mechanism are connected to the support base, and the pressurized filtrate mechanism, the flipping and cleaning mechanism and the drying mechanism are sequentially arranged along the rotation direction of the material receiving shell;

[0008] The precipitation and rising mechanism includes an annular tube, which is fixedly connected to the bottom of the sealing plate, and the top of the annular tube is fixedly connected to multiple air inlet pipes along the circumferential direction. The top ends of the air inlet pipes all penetrate the sealing plate and extend to the interior of the mixing barrel, and the top ends of the air inlet pipes are inclined to one side. A one-way valve is fixedly installed on the air inlet pipes, and a first air pump is fixedly installed on the bottom of the sealing plate. The air inlet end of the first air pump is fixedly connected to the annular tube, and the top of the mixing barrel is fixedly connected to an exhaust pipe, and a pressure relief valve is fixedly installed on the exhaust pipe.

[0009] Preferably, the heating and stirring mechanism includes a rotating shaft and a fixed ring, the rotating shaft is rotatably connected to the axis center of the sealing plate, a plurality of stirring blades are fixedly connected to the surface of the rotating shaft along the circumferential direction, a first motor is fixedly installed at the bottom of the sealing plate, an output shaft of the first motor is fixedly connected to the bottom end of the rotating shaft, the fixed ring is fixedly connected to the surface of the mixing barrel, a plurality of heating rods are fixedly installed circumferentially inside the fixed ring, and the heating ends of the heating rods all pass through the mixing barrel and extend to the inside of the mixing barrel.

[0010] Preferably, the intermittent rotating mechanism includes a rotating seat, which is fixedly connected to the top of the supporting base, a rotating ring is rotatably connected to the surface of the rotating seat, four L-shaped brackets are circumferentially fixedly connected to the surface of the rotating ring, each of the L-shaped brackets is rotatably connected to a connecting shaft, one end of the connecting shaft is fixedly connected to the corresponding material receiving shell, the other end of the connecting shaft is fixedly connected to a limiting block, an annular slide rail is fixedly connected to the top of the rotating seat, the limiting blocks are slidably connected to the annular slide rail, an outer gear ring is fixedly connected to the surface of the rotating ring, a second motor is fixedly installed on the rotating seat, a gear is fixedly connected to the output shaft of the second motor, and the gear and the outer gear ring are meshed.

[0011] Preferably, the pressurized filtrate mechanism includes a first mounting frame, the first mounting frame is fixedly connected to the top of the supporting base, the first mounting frame is fixedly connected to a first connecting shell, the first mounting frame is fixedly installed with a second air pump, the exhaust end of the second air pump is fixedly connected to the top of the first connecting shell, the bottom of the material receiving shell is fixedly connected with a connecting pipe, the connecting pipe is fixedly installed with a second electric control valve, the bottom of the material receiving shell is fixedly installed with a laser receiver, and the first mounting frame is fixedly installed with a laser transmitter.

[0012] Preferably, the flip cleaning mechanism includes an arc-surface notch and a water storage shell, the arc-surface notch is arranged on the annular slide rail, a swing cylinder is fixedly installed on the top of the rotating seat, a matching slide rail is fixedly connected to the piston shaft of the swing cylinder, one end of the matching slide rail is located inside the arc-surface notch, the water storage shell is arranged above the supporting base, two connecting rings are fixedly connected to the side of the water storage shell, limit pins are slidably inserted inside the connecting rings, the limit pins are fixedly connected to the top of the supporting base, a hydraulic cylinder is fixedly installed on the supporting base, and the hydraulic The piston shaft of the pressure cylinder is fixedly connected to the water storage shell, and a first single-way tube is fixedly inserted on the water storage shell. The open end at the top of the first single-way tube extends to the interior of the water storage shell and is fixedly connected to a high-pressure nozzle. The top of the support base is fixedly connected to a second single-way tube, and the first single-way tube is slidably inserted on the second single-way tube. A through hole is opened on the first single-way tube, and the through hole is located below the second single-way tube. A sealing ring is fixedly connected to the second single-way tube, and the sealing ring is located at the bottom of the second single-way tube and is slidably sleeved on the first single-way tube.

[0013] Preferably, a drainage groove is provided at the bottom of the water storage shell, a baffle is provided above the drainage groove, two connecting pins are fixedly connected to the bottom of the baffle, the connecting pins are slidably inserted on the water storage shell, springs are sleeved on the connecting pins, the springs are fixedly connected between the bottom of the water storage shell and the bottom ends of the connecting pins, a guide shell is provided below the water storage shell, the bottom of the guide shell is fixedly connected to a drainage pipe, and the drainage pipe is fixedly inserted on the support base.

[0014] Preferably, the drying mechanism includes a second mounting bracket, the second mounting bracket is fixedly connected to the top of the supporting base, a second connecting shell is fixedly connected to the second mounting bracket, a hot air blower is fixedly mounted on the second connecting shell, and an output end of the hot air blower is connected to the top of the second connecting shell.

[0015] Compared with the prior art, the present invention has the following beneficial effects:

[0016] 1. The transdermal patch adhesive paste inside the docking shell is filtered and discharged through the action of the pressurized filtrate mechanism, and then the inside of the docking shell is cleaned and dried through the action of the flipping cleaning mechanism and the drying mechanism, so that the docking shell continuously processes the transdermal patch adhesive paste during the intermittent rotation, and the docking shell is cleaned and dried in turn, thereby ensuring the filtering effect of the transdermal patch adhesive paste and improving the efficiency of the continuous processing and preparation of the transdermal patch adhesive paste.

[0017] 2. By tilting the top ends of multiple air inlet pipes, the transdermal patch adhesive forms an upward-flowing vortex, so that the sediment at the bottom of the transdermal patch adhesive continuously moves upward during the flow of the transdermal patch adhesive, thereby reducing the sedimentation at the bottom of the transdermal patch adhesive and accelerating the mixing and dissolution of the transdermal patch adhesive. The one-way valve installed on the air inlet pipe prevents the transdermal patch adhesive from flowing into the air inlet pipe, and the exhaust pipe is exhausted outwardly through the action of the pressure relief valve, so that the air pressure inside the mixing cylinder remains stable.

[0018] 3. Start the second air pump and the second electric-controlled valve through the controller connected to the laser receiver. The second air pump delivers gas to the inside of the first connecting shell, and accelerates the transdermal patch adhesive in the receiving shell to penetrate downward and pass through the filter membrane through the air pressure, and then moves through the multiple filtrate holes on the support plate. Then, the connecting pipe switch is opened through the second electric-controlled valve, so that the filtered transdermal patch adhesive is discharged from the corresponding connecting pipe, and then the discharged transdermal patch adhesive is collected.

[0019] 4. The waste water generated by flushing is received by the water storage shell to prevent splashing pollution of the waste water. After the flushing is completed, the water storage shell is returned to the initial position through the reverse operation of the hydraulic cylinder, and the piston shaft of the swing cylinder is reversed to flip the material receiving shell to the initial position. The sealing ring on the second single-way tube seals the sliding joint between the first single-way tube and the second single-way tube, preventing water from spraying outward when the through hole is not fully connected with the inside of the second single-way tube, thereby reducing the waste of water resources. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is a first structural schematic diagram of the present invention;

[0021] Figure 2 For the present invention Figure 1 A schematic diagram of the structure enlargement at point A;

[0022] Figure 3 It is a second structural schematic diagram of the present invention;

[0023] Figure 4 For the present invention Figure 3 A schematic diagram of the structure at B in FIG.

[0024] Figure 5 For the present invention Figure 3 A schematic diagram of the structure at position C in FIG.

[0025] Figure 6 For the present invention Figure 3 A schematic diagram of the structure at D in FIG.

[0026] Figure 7 It is a schematic diagram of the matching structure of the mixing cylinder and the sealing plate of the present invention (the mixing cylinder is cut);

[0027] Figure 8 For the present invention Figure 7 A schematic diagram of the structure at position E in FIG.

[0028] Fig. 9 It is a schematic diagram of the matching structure of the mixing cylinder and the sealing plate of the present invention from a bottom-up perspective;

[0029] Fig.10 It is a schematic diagram of the matching structure of the first mounting frame and the first connecting shell of the present invention;

[0030] Fig.11 It is a schematic diagram of the coordination structure of the water storage housing, the first single-way pipe and the second single-way pipe of the present invention (the water storage housing, the guide housing and the drain pipe are cut);

[0031] Fig.12 For the present invention Fig.11 A magnified schematic diagram of the structure at F in FIG.

[0032] Fig.13 It is a schematic diagram of the matching structure of the material receiving shell and the connecting pipe of the present invention (the material receiving shell is cut away).

[0033] In the figure: 1. support base; 2. mixing barrel; 3. first feed pipe; 4. second feed pipe; 5. sealing plate; 6. discharge pipe; 7. first electric control valve; 8. material receiving shell; 9. support plate; 10. filtrate hole; 11. filter membrane; 12. rotating shaft; 13. fixing ring; 14. stirring blade; 15. first motor; 16. heating rod; 17. annular tube; 18. air inlet pipe; 19. one-way valve; 20. first air pump; 21. exhaust pipe; 22. pressure relief valve; 23. rotating seat; 24. rotating ring; 25. L-shaped bracket; 26. connecting shaft; 27. limit block; 28. annular slide rail; 29. ​​outer gear ring; 30. second motor; 31. gear ; 32. First mounting frame; 33. First connecting shell; 34. Second air pump; 35. Connecting pipe; 36. Second electric control valve; 37. Laser receiver; 38. Laser transmitter; 39. Arc notch; 40. Water storage shell; 41. Swinging cylinder; 42. Matching slide rail; 43. Connecting ring; 44. Limit pin; 45. Hydraulic cylinder; 46. First single-way pipe; 47. High-pressure nozzle; 48. Second single-way pipe; 49. Through hole; 50. Sealing ring; 51. Drain groove; 52. Baffle; 53. Connecting pin; 54. Spring; 55. Guide shell; 56. Drain pipe; 57. Second mounting frame; 58. Second connecting shell; 59. Hot air blower. DETAILED DESCRIPTION

[0034] The following description is used to disclose the present invention so that those skilled in the art can implement the present invention. The preferred embodiments described below are only examples, and those skilled in the art may think of other obvious variations.

[0035] like Figures 1 to 13 A mixing device for preparing transdermal patch adhesive paste is shown, comprising a supporting base 1, a mixing barrel 2 is arranged above the supporting base 1, a first feeding pipe 3 is fixedly connected to the top of the mixing barrel 2, a second feeding pipe 4 is fixedly connected to the top of the side of the mixing barrel 2, a sealing plate 5 is fixedly connected to the opening at the bottom of the mixing barrel 2, the sealing plate 5 is fixedly connected to the supporting base 1, and a heating and stirring mechanism and a precipitation and rising mechanism are connected to the sealing plate 5;

[0036] The bottom of the sealing plate 5 is fixedly connected to a discharge pipe 6 (such as Fig. 9 As shown in FIG. 1 , a first electric control valve 7 is fixedly mounted on the discharge pipe 6, four receiving housings 8 are circumferentially arranged above the support base 1, and a support plate 9 is fixedly connected to the interior of the receiving housing 8 (as shown in FIG. 1 ). Fig.13As shown in the figure, a plurality of filtrate holes 10 are provided on the support plate 9, a filter membrane 11 is fixedly connected to the top of the support plate 9, an intermittent rotating mechanism and a pressurized filtrate mechanism are connected to the material receiving shell 8, and a flip cleaning mechanism and a drying mechanism are connected to the support base 1, and the pressurized filtrate mechanism, the flip cleaning mechanism and the drying mechanism are sequentially arranged along the rotation direction of the material receiving shell 8; during operation, in the prior art, when preparing the transdermal patch adhesive, the transdermal patch adhesive is usually mixed and stirred by stirring the mixing blade, and the transdermal patch adhesive is prone to produce precipitates and sink to the bottom during the stirring process, thereby affecting the uniformity of the transdermal patch adhesive, and in the mixing process, it is difficult to effectively treat the solid impurities produced by the mixing, which reduces the finished product effect of the transdermal patch adhesive; the technical solution can solve the above problems, and the specific working method is as follows: the carrier, adhesive and penetration enhancer used to prepare the transdermal patch adhesive are added to the inside of the mixing barrel 2 along the first feeding pipe 3, and heated and mixed by the action of the heating and stirring mechanism to dissolve and form a glue solution, and then the drug is added to the mixing barrel along the second feeding pipe 4 2, the adhesive is mixed and dissolved with the glue liquid by the heating and stirring mechanism to form a transdermal patch adhesive paste. During the mixing and stirring process, the transdermal patch adhesive paste is continuously tumbled upward by the sedimentation and lifting mechanism, thereby increasing the up and down flow of the transdermal patch adhesive paste and reducing the sedimentation of the transdermal patch adhesive paste to the bottom, accelerating the dissolution of the transdermal patch adhesive paste. After the transdermal patch adhesive paste is mixed and stirred, the discharge pipe 6 is controlled by the first electric control valve 7 to transport the transdermal patch adhesive paste downward, so that the transdermal patch adhesive paste enters the receiving housing 8 below the discharge pipe 6, and is intermittently discharged. The rotating mechanism causes the four material receiving shells 8 to rotate in sequence to the bottom of the discharge pipe 6 to receive the material, and the transdermal patch adhesive inside the material receiving shell 8 is filtered and discharged through the action of the pressurized filtrate mechanism, and then the inside of the material receiving shell 8 is cleaned and dried through the action of the flipping cleaning mechanism and the drying mechanism, so that the material receiving shell 8 continuously processes the transdermal patch adhesive during the intermittent rotation, and the material receiving shell 8 is cleaned and dried in sequence, thereby ensuring the filtering effect of the transdermal patch adhesive and improving the efficiency of the continuous processing and preparation of the transdermal patch adhesive.

[0037] As a further embodiment of the present invention, the heating and stirring mechanism comprises a rotating shaft 12 and a fixing ring 13 (such as Figure 7As shown in the figure, the rotating shaft 12 is rotatably connected to the axis of the sealing plate 5, and a plurality of stirring blades 14 are fixedly connected to the surface of the rotating shaft 12 along the circumferential direction. A first motor 15 is fixedly installed at the bottom of the sealing plate 5, and the output shaft of the first motor 15 is fixedly connected to the bottom end of the rotating shaft 12. The fixing ring 13 is fixedly connected to the surface of the mixing barrel 2, and a plurality of heating rods 16 are fixedly installed inside the fixing ring 13 along the circumferential direction. The heating ends of the heating rods 16 all penetrate the mixing barrel 2 and extend to the inside of the mixing barrel 2; when working, the output shaft of the first motor 15 rotates to drive the rotating shaft 12 to rotate unidirectionally at the rotating connection of the sealing plate 5, so that the plurality of stirring blades 14 stir and mix the transdermal patch adhesive inside the mixing barrel 2, and when the transdermal patch adhesive is located inside the mixing barrel 2, the heating end of the heating rod 16 contacts the transdermal patch adhesive, thereby heating the transdermal patch adhesive, thereby improving the mixing and dissolving efficiency of the transdermal patch adhesive.

[0038] The precipitation and rising mechanism includes an annular tube 17 (such as Fig. 9 As shown, the annular tube 17 is fixedly connected to the bottom of the sealing plate 5, and the top of the annular tube 17 is fixedly connected to multiple air inlet pipes 18 along the circumferential direction. The top ends of the air inlet pipes 18 all penetrate the sealing plate 5 and extend to the inside of the mixing cylinder 2. The top ends of the air inlet pipes 18 are all inclined to one side (as shown in FIG. Figure 8 As shown, a one-way valve 19 is fixedly installed on the air inlet pipe 18, a first air pump 20 is fixedly installed on the bottom of the sealing plate 5, the air inlet end of the first air pump 20 is fixedly connected to the annular pipe 17, and the top of the mixing cylinder 2 is fixedly connected to the exhaust pipe 21 (as shown in FIG. Figure 1 As shown in the figure, a pressure relief valve 22 is fixedly installed on the exhaust pipe 21; when working, gas is transported to the inside of the annular tube 17 through the air inlet end of the first air pump 20, and enters the inside of the air inlet pipe 18 along the connection between the annular tube 17 and the air inlet pipe 18, and finally transported to the inside of the mixing cylinder 2 from the top of the air inlet pipe 18. When the inside of the mixing cylinder 2 is full of transdermal patch adhesive, the gas generated in the mixing cylinder 2 generates bubbles in the transdermal patch adhesive and rises upward, and the transdermal patch adhesive forms an upward-flowing vortex through the inclination of the tops of multiple air inlet pipes 18, so that the sediment at the bottom of the transdermal patch adhesive continuously moves upward during the flow of the transdermal patch adhesive, thereby reducing the sedimentation at the bottom of the transdermal patch adhesive and accelerating the mixed dissolution of the transdermal patch adhesive, and the transdermal patch adhesive is prevented from flowing into the inside of the air inlet pipe 18 by the one-way valve 19 installed on the air inlet pipe 18, and the exhaust pipe 21 is exhausted outwardly through the action of the pressure relief valve 22, so that the air pressure inside the mixing cylinder 2 remains stable.

[0039] As a further embodiment of the present invention, the intermittent rotating mechanism includes a rotating seat 23, the rotating seat 23 is fixedly connected to the top of the supporting base 1, the surface of the rotating seat 23 is rotatably connected to a rotating ring 24, the surface of the rotating ring 24 is fixedly connected to four L-shaped brackets 25 along the circumferential direction, and the L-shaped brackets 25 are rotatably connected to a connecting shaft 26 (such as Figure 4 As shown in FIG. 1 , one end of the connecting shaft 26 is fixedly connected to the corresponding material receiving shell 8, and the other end of the connecting shaft 26 is fixedly connected to the limit block 27. The upper part of the rotating seat 23 is fixedly connected to the annular slide rail 28, and the limit blocks 27 are slidably connected to the annular slide rail 28. The surface of the rotating ring 24 is fixedly connected to the outer gear ring 29 (as shown in FIG. 1 ). Figure 2 As shown in the figure, a second motor 30 is fixedly mounted on the rotating seat 23, and a gear 31 is fixedly connected to the output shaft of the second motor 30, and the gear 31 is meshed with the outer gear ring 29; when working, the output shaft of the second motor 30 rotates to drive the gear 31 to rotate synchronously, and the meshing action of the gear 31 and the outer gear ring 29 causes the rotating ring 24 to rotate along the rotating connection on the surface of the rotating seat 23, thereby driving the L-shaped bracket 25 to rotate synchronously, and the sliding connection of the limit block 27 by the annular slide rail 28 limits the rotation of the connecting shaft 26 on the L-shaped bracket 25, so that the material receiving shell 8 keeps rotating at the same angle, and the intermittent rotation of the second motor 30 causes the material receiving shell 8 to pause after rotating ninety degrees, thereby causing the material receiving shell 8 to rotate intermittently.

[0040] As a further embodiment of the present invention, the pressurized filtrate mechanism includes a first mounting frame 32, the first mounting frame 32 is fixedly connected to the top of the support base 1, a first connecting shell 33 is fixedly connected to the first mounting frame 32, a second air pump 34 is fixedly installed on the first mounting frame 32, the exhaust end of the second air pump 34 is fixedly connected to the top of the first connecting shell 33, and the bottom of the receiving shell 8 is fixedly connected to a connecting pipe 35 (such as Fig.13 As shown in FIG. 1 ), a second electric control valve 36 is fixedly installed on the connecting pipe 35, and a laser receiver 37 (as shown in FIG. 1 ) is fixedly installed on the bottom of the receiving housing 8. Figure 4 and Fig.13 As shown, a laser emitter 38 (as shown in FIG. Fig.10When working, the first electrically controlled valve 7 controls the discharge pipe 6 to transport the transdermal patch adhesive downward, so that the transdermal patch adhesive enters the receiving shell 8 below the discharge pipe 6, and then the receiving shell 8 is rotated ninety degrees by the intermittent rotating mechanism and moves to the bottom of the first communicating shell 33. At the same time, the laser receiver 37 on the corresponding receiving shell 8 receives the laser signal emitted by the laser transmitter 38, and the second air pump 34 and the second electrically controlled valve 36 are started by the controller connected to the laser receiver 37. The second air pump 34 transports gas to the inside of the first communicating shell 33, and accelerates the transdermal patch adhesive in the receiving shell 8 to penetrate downward and pass through the filter membrane 11 through the air pressure, and then moves through the multiple filtrate holes 10 on the support plate 9, and then the connecting pipe 35 switch is opened by the second electrically controlled valve 36, so that the filtered transdermal patch adhesive is discharged from the corresponding connecting pipe 35, and then the discharged transdermal patch adhesive is collected.

[0041] As a further embodiment of the present invention, the flip cleaning mechanism includes a curved surface notch 39 and a water storage shell 40 (such as Figure 5 As shown in the figure, the arc notch 39 is provided on the annular slide rail 28, a swing cylinder 41 is fixedly installed on the top of the rotating seat 23, a matching slide rail 42 is fixedly connected to the piston shaft of the swing cylinder 41, one end of the matching slide rail 42 is located inside the arc notch 39, a water storage shell 40 is arranged above the support base 1, two connecting rings 43 are fixedly connected to the side of the water storage shell 40, and limit pins 44 are slidably inserted inside the connecting rings 43, and the limit pins 44 are fixedly connected to the top of the support base 1, and a hydraulic cylinder 45 is fixedly installed on the support base 1. The piston shaft of the hydraulic cylinder 45 is fixedly connected to the water storage housing 40, a first single-way pipe 46 is fixedly inserted on the water storage housing 40, an open end at the top of the first single-way pipe 46 extends to the inside of the water storage housing 40 and is fixedly connected to a high-pressure nozzle 47, a second single-way pipe 48 is fixedly connected to the top of the support base 1, the first single-way pipe 46 is slidably inserted on the second single-way pipe 48, a through hole 49 is opened on the first single-way pipe 46, the through hole 49 is located below the second single-way pipe 48, and a sealing ring 50 (such as Fig.12As shown in the figure, the sealing ring 50 is located at the bottom of the second single-way tube 48 and is slidably sleeved on the first single-way tube 46; during operation, after the transdermal patch paste inside the receiving shell 8 is filtered and discharged, the receiving shell 8 continues to rotate to the top of the water storage shell 40 through the action of the intermittent rotating mechanism, and at the same time, the limiting block 27 corresponding to the receiving shell 8 slides to the arc surface notch 39 of the annular slide rail 28, and continues to slide and limit through the matching slide rail 42, and then the piston shaft of the swing cylinder 41 drives the matching slide rail 42 to rotate 180 degrees, so that the limiting block 27 is rotated to the arc surface notch 39 of the annular slide rail 28, and then the piston shaft of the swing cylinder 41 drives the matching slide rail 42 to rotate 180 degrees, so that the limiting block 27 is rotated to the arc surface notch 39 of the annular slide rail 28, and then the matching slide rail 42 ... The block 27 rotates synchronously and drives the connecting shaft 26 to rotate synchronously, so that the material receiving shell 8 is turned over and the opening of the material receiving shell 8 faces downward, and then the piston shaft of the hydraulic cylinder 45 moves upward and drives the water storage shell 40 to move synchronously, the first single-way pipe 46 moves synchronously with the water storage shell 40 and slides upward along the sliding connection of the second single-way pipe 48, the connecting ring 43 on the water storage shell 40 slides along the limit pin 44 and moves the water storage shell 40. When the water storage shell 40 and the opening of the material receiving shell 8 after turning over come into contact, The through hole 49 on the first single-way tube 46 moves to the inside of the second single-way tube 48 and communicates with the inside of the second single-way tube 48. By connecting a water source to the open end of the second single-way tube 48, the water source enters the inside of the first single-way tube 46 along the connection between the second single-way tube 48 and the through hole 49, and is sprayed out along the high-pressure nozzle 47 on the top of the first single-way tube 46, thereby flushing the inside of the material receiving shell 8 and the surface of the filter membrane 11 after the inversion, cleaning the impurities inside the material receiving shell 8 and ensuring the subsequent filtering effect of the filter membrane 11 The waste water generated by flushing is received by the water storage shell 40 to prevent splashing pollution of the waste water. After the flushing is completed, the water storage shell 40 returns to the initial position through the reverse operation of the hydraulic cylinder 45, and the piston shaft of the swing cylinder 41 reverses to flip the material receiving shell 8 to the initial position. The sealing ring 50 on the second single-way tube 48 seals the sliding connection between the first single-way tube 46 and the second single-way tube 48, thereby preventing water from spraying outward when the through hole 49 is not fully connected with the inside of the second single-way tube 48, thereby reducing the waste of water resources.

[0042] As a further embodiment of the present invention, a drainage groove 51 (such as Fig.12As shown in the figure, a baffle plate 52 is arranged above the drainage groove 51, and two connecting pins 53 are fixedly connected to the bottom of the baffle plate 52, and the connecting pins 53 are all slidably inserted on the water storage shell 40, and springs 54 are sleeved on the connecting pins 53, and the springs 54 are fixedly connected between the bottom of the water storage shell 40 and the bottom end of the connecting pins 53, and a guide shell 55 is arranged below the water storage shell 40, and the bottom of the guide shell 55 is fixedly connected to a drainage pipe 56, and the drainage pipe 56 is fixedly inserted on the support base 1; when working, when the water storage shell 40 returns to the initial position through the work of the hydraulic cylinder 45, the two connecting pins 53 move downward synchronously and move to the inside of the guide shell 55, and the connecting pins 53 The bottom end of the water storage shell 40 contacts and squeezes the bottom surface of the guide shell 55, so that the connecting pin 53 moves upward along the sliding connection of the water storage shell 40 and squeezes the spring 54 to produce compression deformation, and the baffle 52 moves upward from the top of the drainage groove 51, so that the waste water inside the water storage shell 40 flows along the drainage groove 51 to the inside of the guide shell 55 and is discharged along the drainage pipe 56. When the water storage shell 40 moves upward, the connecting pin 53 loses the contact and squeezing of the guide shell 55, and the baffle 52 is close to the bottom surface of the water storage shell 40 under the elastic extension action of the spring 54, thereby blocking the drainage groove 51 and ensuring the water storage effect when the water storage shell 40 contacts the material receiving shell 8.

[0043] As a further embodiment of the present invention, the drying mechanism includes a second mounting frame 57 (such as Figure 6 As shown), the second mounting frame 57 is fixedly connected to the top of the supporting base 1, and a second connecting shell 58 is fixedly connected to the second mounting frame 57, and a hot air blower 59 is fixedly installed on the second connecting shell 58, and the output end of the hot air blower 59 is connected to the top of the second connecting shell 58; when working, the rinsed receiving shell 8 is rotated to the bottom of the second connecting shell 58 by the action of the intermittent rotating mechanism, and the drying hot air is transported to the inside of the second connecting shell 58 through the output end of the hot air blower 59, thereby drying the water stains inside the receiving shell 8, reducing the influence of moisture on the receiving shell 8 of the transdermal patch adhesive.

[0044] Working principle of the present invention:

[0045] The carrier, adhesive and penetration enhancer for preparing the transdermal patch glue are added into the mixing drum 2 along the first feeding pipe 3, and heated and mixed by the heating and stirring mechanism to dissolve to form glue solution. Then, the drug is added into the mixing drum 2 along the second feeding pipe 4, and mixed and dissolved with the glue solution by the heating and stirring mechanism to form the transdermal patch glue. During the mixing and stirring process, the transdermal patch glue is continuously churned upward by the sedimentation and rising mechanism, thereby increasing the up and down flow of the transdermal patch glue, reducing the sedimentation in the transdermal patch glue, and accelerating the dissolution of the transdermal patch glue. After the transdermal patch glue is mixed and stirred, the first electric control valve 7 is controlled to make the The discharge pipe 6 transports the transdermal patch adhesive downward, so that the transdermal patch adhesive enters the material receiving shell 8 below the discharge pipe 6, and the intermittent rotating mechanism makes the four material receiving shells 8 rotate to the bottom of the discharge pipe 6 in turn to receive the material, and the pressurized filtrate mechanism is used to filter and discharge the transdermal patch adhesive inside the material receiving shell 8, and then the inside of the material receiving shell 8 is cleaned and dried by the flipping cleaning mechanism and the drying mechanism, so that the material receiving shell 8 continuously processes the transdermal patch adhesive during the intermittent rotation, and at the same time, the material receiving shell 8 is cleaned and dried in turn, thereby ensuring the filtering effect of the transdermal patch adhesive and improving the efficiency of the continuous processing and preparation of the transdermal patch adhesive.

[0046] The above shows and describes the basic principles, main features and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments, and the above embodiments and descriptions only describe the principles of the present invention. The present invention may have various changes and improvements without departing from the spirit and scope of the present invention, and these changes and improvements fall within the scope of the present invention to be protected, and the scope of protection claimed by the present invention is defined by the attached claims and their equivalents.

Claims

1. A mixing device for preparing transdermal patch adhesive, comprising a supporting base (1), characterized in that: A mixing drum (2) is arranged above the support base (1); a first feed pipe (3) is fixedly connected to the top of the mixing drum (2); a second feed pipe (4) is fixedly connected to the top of the side of the mixing drum (2); a sealing plate (5) is fixedly connected to the opening at the bottom of the mixing drum (2); the sealing plate (5) is fixedly connected to the support base (1); and a heating and stirring mechanism and a sedimentation and rising mechanism are connected to the sealing plate (5); The bottom of the sealing plate (5) is fixedly connected to a discharge pipe (6), a first electrically controlled valve (7) is fixedly mounted on the discharge pipe (6), four material receiving shells (8) are circumferentially arranged above the support base (1), a support plate (9) is fixedly connected to the inside of the material receiving shell (8), a plurality of filtrate holes (10) are provided on the support plate (9), a filter membrane (11) is fixedly connected to the top of the support plate (9), an intermittent rotating mechanism and a pressurized filtrate mechanism are connected to the material receiving shell (8), a flipping and cleaning mechanism and a drying mechanism are connected to the support base (1), and the pressurized filtrate mechanism, the flipping and cleaning mechanism and the drying mechanism are arranged in sequence along the rotation direction of the material receiving shell (8); The precipitation and rising mechanism comprises an annular tube (17), the annular tube (17) being fixedly connected to the bottom of the sealing plate (5), the top of the annular tube (17) being fixedly connected to a plurality of air inlet pipes (18) along the circumferential direction, the top ends of the air inlet pipes (18) all passing through the sealing plate (5) and extending to the interior of the mixing barrel (2), the top ends of the air inlet pipes (18) all being inclined to one side, the air inlet pipes (18) being fixedly mounted with a one-way valve (19), the bottom of the sealing plate (5) being fixedly mounted with a first air pump (20), the air inlet end of the first air pump (20) being fixedly connected to the annular tube (17), the top of the mixing barrel (2) being fixedly connected to an exhaust pipe (21), the exhaust pipe (21) being fixedly mounted with a pressure relief valve (22); The intermittent rotating mechanism comprises a rotating seat (23), the rotating seat (23) being fixedly connected to the top of the supporting base (1), a rotating ring (24) being rotatably connected to the surface of the rotating seat (23), four L-shaped brackets (25) being fixedly connected to the surface of the rotating ring (24) along the circumferential direction, each of the L-shaped brackets (25) being rotatably connected to a connecting shaft (26), one end of each of the connecting shafts (26) being fixedly connected to the corresponding material receiving shell (8), and the other end of each of the connecting shafts (26) being fixedly connected to a limiting block (27), an annular slide rail (28) being fixedly connected to the top of the rotating seat (23), each of the limiting blocks (27) being slidably connected to the annular slide rail (28), an outer toothed ring (29) being fixedly connected to the surface of the rotating ring (24), a second motor (30) being fixedly mounted on the rotating seat (23), a gear (31) being fixedly connected to the output shaft of the second motor (30), and the gear (31) being meshed with the outer toothed ring (29); The pressurized filtrate mechanism comprises a first mounting frame (32), the first mounting frame (32) being fixedly connected to the top of the support base (1), a first connecting shell (33) being fixedly connected to the first mounting frame (32), a second air pump (34) being fixedly mounted on the first mounting frame (32), an exhaust end of the second air pump (34) being fixedly connected to the top of the first connecting shell (33), a connecting pipe (35) being fixedly connected to the bottom of the material receiving shell (8), a second electric control valve (36) being fixedly mounted on the connecting pipe (35), a laser receiver (37) being fixedly mounted on the bottom of the material receiving shell (8), and a laser transmitter (38) being fixedly mounted on the first mounting frame (32).

2. A mixing device for preparing transdermal patch adhesive according to claim 1, characterized in that: The heating and stirring mechanism comprises a rotating shaft (12) and a fixing ring (13); the rotating shaft (12) is rotatably connected to the axis of the sealing plate (5); a plurality of stirring blades (14) are fixedly connected to the surface of the rotating shaft (12) along the circumferential direction; a first motor (15) is fixedly mounted on the bottom of the sealing plate (5); an output shaft of the first motor (15) is fixedly connected to the bottom end of the rotating shaft (12); the fixing ring (13) is fixedly connected to the surface of the mixing barrel (2); a plurality of heating rods (16) are fixedly mounted inside the fixing ring (13) along the circumferential direction; the heating ends of the heating rods (16) all penetrate the mixing barrel (2) and extend into the interior of the mixing barrel (2).

3. A mixing device for preparing transdermal patch adhesive according to claim 1, characterized in that: The flip cleaning mechanism comprises an arc-surface notch (39) and a water storage shell (40), wherein the arc-surface notch (39) is provided on the annular slide rail (28), a swing cylinder (41) is fixedly mounted on the top of the rotating seat (23), a matching slide rail (42) is fixedly connected to the piston shaft of the swing cylinder (41), one end of the matching slide rail (42) is located inside the arc-surface notch (39), the water storage shell (40) is arranged above the support base (1), two connecting rings (43) are fixedly connected to the side of the water storage shell (40), limit pins (44) are slidably inserted inside the connecting rings (43), and the limit pins (44) are fixedly connected to the top of the support base (1), and a hydraulic cylinder (45) is fixedly mounted on the support base (1), and the hydraulic cylinder ( The piston shaft of the support base (1) is fixedly connected to the water storage shell (40), and a first single-way tube (46) is fixedly inserted on the water storage shell (40). The open end at the top of the first single-way tube (46) extends to the inside of the water storage shell (40) and is fixedly connected to a high-pressure nozzle (47). The top of the support base (1) is fixedly connected to a second single-way tube (48), and the first single-way tube (46) is slidably inserted on the second single-way tube (48). A through hole (49) is opened on the first single-way tube (46), and the through hole (49) is located below the second single-way tube (48). A sealing ring (50) is fixedly connected to the second single-way tube (48), and the sealing ring (50) is located at the bottom of the second single-way tube (48) and is slidably sleeved on the first single-way tube (46).

4. A mixing device for preparing transdermal patch adhesive according to claim 3, characterized in that: A drainage groove (51) is provided at the bottom of the water storage housing (40), a baffle (52) is provided above the drainage groove (51), two connecting pins (53) are fixedly connected to the bottom of the baffle (52), the connecting pins (53) are slidably inserted on the water storage housing (40), springs (54) are sleeved on the connecting pins (53), the springs (54) are fixedly connected between the bottom of the water storage housing (40) and the bottom ends of the connecting pins (53), a guide housing (55) is provided below the water storage housing (40), the bottom of the guide housing (55) is fixedly connected to a drainage pipe (56), and the drainage pipe (56) is fixedly inserted on the support base (1).

5. A mixing device for preparing transdermal patch adhesive according to claim 3, characterized in that: The drying mechanism comprises a second mounting frame (57), the second mounting frame (57) being fixedly connected to the top of the supporting base (1), a second connecting shell (58) being fixedly connected to the second mounting frame (57), a hot air blower (59) being fixedly mounted on the second connecting shell (58), and an output end of the hot air blower (59) being connected to the top of the second connecting shell (58).

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