Device special for mouse body position fixing and local radiotherapy

Abstract

The device comprises a lead alloy shielding box, the top end and the front side of the lead alloy shielding box are both provided with openings, a body position fixing mechanism is placed in the lead alloy shielding box, and a local radiotherapy collimation mechanism is installed at the top end of the lead alloy shielding box. The fixing mechanism comprises a plug board, a head fixing module, a limb fixing module and a trunk fixing module, the local radiotherapy collimation mechanism comprises four vertical rods, a cross rod, a first multi-page lead alloy collimator and a second multi-page lead alloy collimator, and the first multi-page lead alloy collimator and the second multi-page lead alloy collimator are vertically staggered in a horizontal-vertical mode. The body position fixing mechanism adopts a fixed design of a plurality of modules such as a head, four limbs and a trunk, ensures that a mouse keeps a stable body position in the radiotherapy process, avoids errors possibly caused by slight movement in an anesthesia state, not only improves the experiment precision, but also reduces the burden of repeated operation of researchers.

Description

Technical Field

[0001] The invention relates to the field of radiation experiment and biomedical technology, and in particular to a device specially used for body position fixation and local radiotherapy of mice. Background Art

[0002] In preclinical cancer research, the application of experimental animal models is crucial, especially in the fields of drug development and treatment method verification. Experimental animal models bearing tumors play an irreplaceable role. Among them, subcutaneous tumor-bearing mice have become the most widely used experimental animal model because of their simple establishment and controllable operation. Subcutaneous tumor-bearing mouse models usually simulate the growth and development of human tumors by implanting tumor cells under the skin of mice, providing an effective platform for drug screening, treatment evaluation and radiotherapy research.

[0003] In the research process of tumor radiotherapy, radiotherapy experiments on subcutaneous tumor-bearing mice have important preclinical significance, especially in the development and evaluation of radiosensitizers and anticancer drugs. Such experiments have very high requirements for equipment and operation, especially when achieving precise radiotherapy, which requires strict position fixation of mice and local exposure of tumors to ensure that the radiation can accurately irradiate the tumor site while avoiding radiation damage to normal tissues and organs.

[0004] Currently, researchers often use large clinical radiotherapy equipment to conduct radiotherapy experiments on mice. However, this type of equipment is mainly designed for human treatment and does not take into account the special needs of experimental mice in terms of size, body position adjustment, and precise positioning of radiotherapy sites. Therefore, when using these devices to conduct radiotherapy experiments on mice, researchers often encounter a series of technical difficulties.

[0005] First, traditional fixation devices cannot meet the special needs of experimental mice. Due to the small size of mice, fixation equipment often cannot ensure that mice maintain a stable position during radiotherapy. This will not only cause the radiation to fail to accurately irradiate the tumor site, but also increase errors, affecting the repeatability and reliability of experimental results. Especially under anesthesia, the spontaneous activity of mice is reduced, but there is still the possibility of slight movement, which is a key issue for precise radiotherapy experiments.

[0006] Secondly, tumor exposure is the key to ensuring the effectiveness of radiotherapy. In previous experiments, due to the lack of specially designed collimators or shielding devices, the radiation often affects the surrounding normal tissues, especially some important organs, during irradiation, increasing unnecessary radiation damage. Therefore, it is difficult for existing equipment to ensure sufficient exposure of the tumor and effective protection of normal tissues without affecting the normal physiological functions of mice.

[0007] At the same time, the ease of use of experimental equipment is also an important consideration. The workload of researchers is heavy, and cumbersome operations may lead to increased experimental errors. Some existing equipment is very complicated in actual operation, especially when adjusting the mouse position and placing shielding devices, which is prone to errors.

[0008] In order to conduct radiotherapy experiments smoothly, the following five basic conditions must be met: first, provide effective anesthesia to ensure the stability of mice during the experiment; second, properly fix the mice to prevent experimental errors caused by their movement; third, ensure that the tumor is fully exposed to radiation to ensure the accuracy of treatment; fourth, take effective measures to protect normal organs to avoid unnecessary radiation damage; fifth, minimize experimental errors and improve the repeatability and reliability of the experiment. However, existing experimental equipment, especially the devices used to fix mice, cannot meet the experimental requirements. Summary of the invention

[0009] The technical problem to be solved by the present invention is to overcome the defects of the prior art and provide a device dedicated to mouse position fixation and local radiotherapy, which solves the following deficiencies of the prior art: first, the stability of the mouse position and the fixation effect are significantly improved; second, the balance between tumor exposure and normal tissue protection is optimized; third, the ease of operation of the device is enhanced. Through these improvements, the present invention can greatly improve the reliability and accuracy of mouse radiotherapy experiments, ensure the repeatability of experimental results, and provide a more effective tool for preclinical research related to cancer treatment.

[0010] The present invention provides the following technical solutions:

[0011] The present invention provides a device specially used for body position fixation and local radiotherapy of mice, comprising a lead alloy shielding box, the top and front side of the lead alloy shielding box are both open, a body position fixing mechanism is placed inside the lead alloy shielding box, a local radiotherapy collimation mechanism is installed on the top of the lead alloy shielding box, the fixing mechanism comprises a plug board, a head fixing module, a limb fixing module and a trunk fixing module, a plurality of plug holes are evenly arranged on the surface of the plug board, a connection block is arranged at the bottom of the head fixing module, the limb fixing module and the trunk fixing module, and a The local radiotherapy collimation mechanism comprises four vertical poles, a horizontal pole, a first multi-page lead alloy collimator and a second multi-page lead alloy collimator. The vertical poles are respectively installed at the four corners of the top of the lead alloy shielding box, and a placement rod is connected between the tops of the vertical poles. The horizontal rod is installed at the top of the front opening of the lead alloy shielding box. The first multi-page lead alloy collimator is attached to the short side of the top of the lead alloy shielding box, and the second multi-page lead alloy collimator is attached to the long side of the top of the placement rod. The first multi-page lead alloy collimator and the second multi-page lead alloy collimator are staggered horizontally and vertically.

[0012] As a preferred technical solution of the present invention, the plug board includes a plexiglass plate, a thin iron plate and a rubber pad composite from top to bottom, and a magnetic block is embedded at the bottom end of the plug.

[0013] As a preferred technical solution of the present invention, the head fixing module includes a fixed ear, a movable ear, a pushing arm, a clamping arm and a screw rod. The fixed ear is fixedly installed on the top of the connecting block, the two ends of the fixed ear are hinged to the clamping arm, the two ends of the movable ear are hinged to the pushing arm, the other end of the pushing arm is hinged to the middle part of the clamping arm, and the screw rod passes through the fixed ear and is movably connected to the movable ear.

[0014] As a preferred technical solution of the present invention, the clamping arm is a folding rod, and a flexible material is provided at the end of the folding rod.

[0015] As a preferred technical solution of the present invention, the limb fixation module includes a strap head, a strap, an arch ear and a locking screw head. The strap head and the arch ear are respectively installed on both sides of the top of the connecting block. The strap head is fixedly connected to the strap. The other end of the strap passes through the arch ear, and the screw of the locking screw head passes through the inside of the arch ear.

[0016] As a preferred technical solution of the present invention, the trunk fixing module includes a lifting rod and a limiting folding rod, the lifting rod is installed on the top of the connecting block, and the top of the lifting rod is connected to the limiting folding rod.

[0017] As a preferred technical solution of the present invention, a plurality of rollers are embedded in the bottom layer of the inner cavity of the lead alloy shielding box.

[0018] Compared with the prior art, the present invention has the following beneficial effects:

[0019] 1: The body position fixing mechanism of the present invention adopts a fixing design of multiple modules of the head, limbs and torso, which ensures that the mouse maintains a stable body position during radiotherapy and avoids errors that may be caused by slight movements under anesthesia. This not only improves the accuracy of the experiment, but also reduces the burden of repeated operations on researchers.

[0020] 2: The present invention freely arranges the positions of multi-page lead alloy collimators, and the upper and lower layers of multi-page lead alloy collimators are staggered to form through holes, which can achieve local exposure of the tumor site and shield normal tissues at the same time, reducing radiation damage to the healthy organs of mice during radiotherapy, making it suitable for a variety of tumor models, and has wide adaptability and flexibility.

[0021] 3: The device of the present invention has a simple structural design and is easy to operate. Researchers can quickly fix the body position of mice and adjust the collimator, which reduces the experimental preparation time. At the same time, the modular design of the device improves the reusability and maintenance convenience of the device, greatly improving the experimental efficiency.

[0022] 4: The present invention ensures the accuracy and repeatability of radiotherapy. The combination of the body position fixation mechanism and the local radiotherapy collimation mechanism can minimize experimental errors, ensure that the experimental results have high repeatability, and provide more reliable experimental conditions for preclinical radiotherapy related research. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. In the accompanying drawings:

[0024] Figure 1 It is a schematic diagram of the overall structure of the present invention;

[0025] Figure 2 It is a structural schematic diagram of the body position fixing mechanism of the present invention;

[0026] Figure 3 It is a schematic diagram of the structure of the head fixing module of the present invention;

[0027] Figure 4 It is a structural schematic diagram of a limb fixation module of the present invention;

[0028] Figure 5 It is a schematic diagram of the structure of the trunk fixing module of the present invention;

[0029] Figure 6 It is a partial cross-sectional schematic diagram of the connection block and the plug board of the present invention;

[0030] Figure 7 It is a schematic diagram of the structure of the lead alloy shielding box of the present invention;

[0031] In the figure: 1. lead alloy shielding box; 2. body position fixing mechanism; 3. local radiotherapy collimation mechanism; 11. roller; 21. plug board; 22. head fixing module; 23. limb fixing module; 24. trunk fixing module; 25. jack; 26. connecting block; 27. plug; 31. vertical pole; 32. horizontal pole; 33. first multi-page lead alloy collimator; 34. second multi-page lead alloy collimator; 35. placing rod; 211. plexiglass plate; 212. thin iron plate; 213. rubber pad; 271. magnetic block; 221. fixed ear; 222. movable ear; 223. push arm; 224. clamping arm; 225. screw; 231. strap head; 232. strap; 233. arch ear; 234. locking screw head; 241. lifting rod; 242. limit folding rod. DETAILED DESCRIPTION

[0032] The preferred embodiments of the present invention are described below in conjunction with the accompanying drawings. It should be understood that the preferred embodiments described herein are only used to illustrate and explain the present invention, and are not used to limit the present invention.

[0033] Example 1

[0034] like Figure 1-7 As shown, the present invention provides a device dedicated to body position fixation and local radiotherapy of mice, comprising a lead alloy shielding box 1, the top and front side of the lead alloy shielding box 1 are both open, a body position fixing mechanism 2 is placed inside the lead alloy shielding box 1, a local radiotherapy collimation mechanism 3 is installed on the top of the lead alloy shielding box 1, the fixing mechanism 2 comprises a plug board 21, a head fixing module 22, a limb fixing module 23 and a trunk fixing module 24, a plurality of jacks 25 are evenly arranged on the surface of the plug board 21, a connection block 26 is arranged at the bottom of the head fixing module 22, the limb fixing module 23 and the trunk fixing module 24, and a plug is installed at the bottom of the connection block 26 27, and the plug 27 matches the size of the socket 25, the local radiotherapy collimation mechanism 3 includes four vertical rods 31, a horizontal rod 32, a first multi-page lead alloy collimator 33 and a second multi-page lead alloy collimator 34, the vertical rods 31 are respectively installed at the four corners of the top of the lead alloy shielding box 1, a placement rod 35 is connected between the tops of the vertical rods 31, the horizontal rod 32 is installed at the top of the front opening of the lead alloy shielding box 1, the first multi-page lead alloy collimator 33 is attached to the short side of the top of the lead alloy shielding box 1, the second multi-page lead alloy collimator 34 is attached to the long side of the top of the placement rod 35, and the first multi-page lead alloy collimator 33 and the second multi-page lead alloy collimator 34 are vertically staggered.

[0035] Furthermore, the plug board 21 includes a composite organic glass plate 211, a thin iron plate 212 and a rubber pad 213 from top to bottom. A magnetic block 271 is embedded at the bottom end of the plug 27. The magnet 271 is adsorbed on the thin iron plate 212, so that the connecting block 26 connected to the plug 27 will not shake easily after insertion; the rubber pad 213 is placed on a flat desktop after the plug board 21 is pulled out and is not easy to move.

[0036] Furthermore, the head fixing module 22 includes a fixed ear 221, a movable ear 222, a pushing arm 223, a clamping arm 224 and a screw 225. The fixed ear 221 is fixedly installed on the top of the connecting block 26, both ends of the fixed ear 221 are hinged to the clamping arm 224, both ends of the movable ear 222 are hinged to the pushing arm 223, the other end of the pushing arm 223 is hinged to the middle part of the clamping arm 224, and the screw 225 passes through the fixed ear 221 and is movably connected to the movable ear 222.

[0037] Furthermore, the clamp arm 224 is a folding rod, and a flexible material is provided at the end of the folding rod, so that the clamp arm can fix the mouse head. The flexible material is silicone here, which can avoid excessive pressure on the mouse head and adverse effects on its respiratory tract and blood circulation.

[0038] Furthermore, the limb fixation module 23 includes a strap head 231, a strap 232, an arch ear 233 and a locking screw head 234. The strap head 231 and the arch ear 233 are respectively installed on both sides of the top of the connecting block 26. The strap head 231 is fixedly connected to the strap 232. The other end of the strap 232 passes through the arch ear 233. The screw of the locking screw head 234 passes through the inside of the arch ear 233.

[0039] Furthermore, the trunk fixing module 24 includes a lifting rod 241 and a limiting folding rod 242 . The lifting rod 241 is installed on the top of the connecting block 26 , and the top of the lifting rod 241 is connected to the limiting folding rod 242 .

[0040] Furthermore, a plurality of rollers 11 are embedded in the bottom layer of the inner cavity of the lead alloy shielding box 1, so that the plug-in board 21 can be pulled out and pushed into the lead alloy shielding box 1 more smoothly without dry friction.

[0041] Specifically, at the beginning of the experiment, the mice were first anesthetized to ensure that they were in a static state during the entire radiotherapy process. Subsequently, the researchers pulled out the position fixing mechanism 2 from the lead alloy shielding box 1, placed the mice flat on the plug board 21, and then adjusted the positions of the head fixing module 22, limb fixing module 23, and trunk fixing module 24 according to the body shape of the mice. The magnetic block 271 at the bottom of the plug 27 and the thin iron plate 212 of the plug board 21 were attracted to each other, so that the connection block 26 was not easy to shake and detach, and the fixing module on the top of the connection block 26 could also remain stable;

[0042] The head fixing module 22 is located above the mouse head, and the movable ear 222 is pushed by rotating the screw rod 225, and the movable ear 222 drives the pushing arm 223, and the pushing arm 223 drives the clamping arm 224 to open and close, thereby clamping the mouse head;

[0043] The limb fixing module 23 is located at the limbs of the mouse. After the limbs of the mouse are placed on the connecting block 26, the strap 232 is passed through the bottom opening of the arch ear 233. After the strap 233 is tightened, the locking screw head 234 is locked to fix the strap 233, thereby fixing the limbs of the mouse.

[0044] The trunk fixing module 24 is located beside the mouse trunk. By rotating or stretching the lifting rod 241, the position and height of the limit folding rod 242 are adjusted, thereby stabilizing the mouse trunk and leaving necessary open space for radiotherapy operation.

[0045] After the mouse is fixed, push the position fixing mechanism 2 back into the lead alloy shielding box 1. Finally, adjust the first multi-page lead alloy collimator 33 and the second multi-page lead alloy collimator 34 of the local radiotherapy collimation mechanism 3 according to the position of the tumor. The first multi-page lead alloy collimator 33 is arranged horizontally, and the second multi-page lead alloy collimator 34 is arranged vertically. The ends of the lead alloy collimators are bent inward so that they can be buckled on the corresponding long and short sides without deviation. When they are arranged side by side, they are tight without gaps. By adjusting the staggered positions of the lead alloy collimators, the position exposed in the vertical direction of the mouse is the tumor area, and the normal tissue is shielded by the lead alloy collimator;

[0046] After the radiotherapy equipment is started, the rays are concentrated on the tumor site through the opening of the collimator, and the surrounding healthy tissue will be shielded by the lead alloy to avoid unnecessary radiation damage. The entire operation process greatly simplifies the researchers' operating steps through optimized design, while ensuring the accuracy and repeatability of the experiment.

[0047] Finally, it should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A device specially used for mouse position fixation and local radiotherapy, characterized in that: The invention comprises a lead alloy shielding box (1), the top and front side of the lead alloy shielding box (1) are both open, a body position fixing mechanism (2) is placed inside the lead alloy shielding box (1), a local radiotherapy collimation mechanism (3) is installed on the top of the lead alloy shielding box (1), the fixing mechanism (2) comprises a plug board (21), a head fixing module (22), a limb fixing module (23) and a trunk fixing module (24), a surface of the plug board (21) is evenly arranged with a plurality of jacks (25), the bottom of the head fixing module (22), the limb fixing module (23) and the trunk fixing module (24) are all provided with a connecting block (26), the bottom of the connecting block (26) is installed with a plug (27), and the plug (27) and the jack (25) are connected to each other. 25) in size, the local radiotherapy collimation mechanism (3) comprises four vertical rods (31), a horizontal rod (32), a first multi-page lead alloy collimator (33) and a second multi-page lead alloy collimator (34), the vertical rods (31) are respectively installed at the four corners of the top of the lead alloy shielding box (1), a placement rod (35) is connected between the tops of the vertical rods (31), the horizontal rod (32) is installed at the top of the front opening of the lead alloy shielding box (1), the first multi-page lead alloy collimator (33) is attached to the short side of the top of the lead alloy shielding box (1), the second multi-page lead alloy collimator (34) is attached to the long side of the top of the placement rod (35), and the first multi-page lead alloy collimator (33) and the second multi-page lead alloy collimator (34) are vertically staggered.

2. A device specifically used for mouse position fixation and local radiotherapy according to claim 1, characterized in that: The plug board (21) comprises a composite organic glass plate (211), a thin iron plate (212) and a rubber pad (213) from top to bottom, and a magnetic block (271) is embedded at the bottom end of the plug (27).

3. The device for mouse position fixation and local radiotherapy according to claim 1, characterized in that: The head fixing module (22) comprises a fixed ear (221), a movable ear (222), a pushing arm (223), a clamping arm (224) and a screw rod (225); the fixed ear (221) is fixedly mounted on the top of the connecting block (26); two ends of the fixed ear (221) are hinged to the clamping arm (224); two ends of the movable ear (222) are hinged to the pushing arm (223); the other end of the pushing arm (223) is hinged to the middle of the clamping arm (224); and the screw rod (225) passes through the fixed ear (221) and is movably connected to the movable ear (222).

4. The device for mouse position fixation and local radiotherapy according to claim 3, characterized in that: The clamp arm (224) is a folding rod, and a flexible material is provided at the end of the folding rod.

5. The device for mouse position fixation and local radiotherapy according to claim 1, characterized in that: The limb fixing module (23) comprises a binding head (231), a binding strap (232), an arch ear (233) and a locking screw head (234); the binding head (231) and the arch ear (233) are respectively mounted on both sides of the top of the connecting block (26); the binding head (231) is fixedly connected to the binding strap (232); the other end of the binding strap (232) passes through the arch ear (233); and the screw of the locking screw head (234) passes through the inside of the arch ear (233).

6. The device for mouse body position fixation and local radiotherapy according to claim 1, characterized in that: The trunk fixing module (24) comprises a lifting rod (241) and a limiting folding rod (242); the lifting rod (241) is mounted on the top end of the connecting block (26); and the top end of the lifting rod (241) is connected to the limiting folding rod (242).

7. The device for mouse position fixation and local radiotherapy according to claim 1, characterized in that: A plurality of rollers (11) are embedded in the bottom layer of the inner cavity of the lead alloy shielding box (1).

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