Prosthesis system and delivery device

Abstract

The embodiments of the present application relate to the technical field of medical devices, and in particular to a prosthesis system, comprising a delivery device and a prosthesis; the delivery device comprises a connecting shaft and a control wire; the prosthesis comprises a base and a first movable part; a preset channel is provided on the connecting shaft and / or the base; the control wire has a first section, a second section, and a third section connected in sequence, the size of at least the portion of the first section and the third section connected to the second section being larger than the size of the second section, and the second section is accommodated in the preset channel; when the preset channel is in a first state, the first section and the third section constrain the second section to the preset channel; when the preset channel is in a second state, the control wire is allowed to separate from the preset channel. The embodiments of the present application also provide a delivery device. The prosthesis system and delivery device provided by the embodiments of the present application reduce surgical risks when the delivery device can safely and reliably adjust the movable parts in the prosthesis.

Description

[0001] This application is a divisional application based on the Chinese invention patent application with the application date of August 29, 2022, application number 202211057484.4, and name “A Prosthesis System and Delivery Device”. Technical Field

[0002] The embodiments of the present application relate to the technical field of medical devices, and in particular to a prosthesis system and a delivery device. Background Art

[0003] With the development of science and technology, minimally invasive surgery has penetrated into various fields of surgery. Due to its advantages of less trauma, less pain and faster recovery, minimally invasive surgery has been welcomed by the majority of patients.

[0004] Existing minimally invasive surgeries mostly use a delivery device to deliver the prosthesis to the target location in the human body through surgical pathways such as natural cavities in the human body. The state of the prosthesis is then adjusted using a control wire that is movably connected to the prosthesis, and the purpose of the surgery is finally achieved by implanting the prosthesis in the human body.

[0005] U.S. Patent Document US20210145574A1 discloses a method for performing minimally invasive surgery. In U.S. Patent Document US20210145574A1, one end of the control wire has a convex point, and the other end passes through the connecting shaft of the delivery device and is movably connected to the prosthesis before extending to the proximal end of the delivery device. At this time, the convex point is restricted by the configuration of the connecting shaft and the center rod of the delivery device so that it cannot pass through the connecting shaft in the direction in which the control wire extends, so that the operator can operate the end of the control wire away from its convex point at the proximal end of the delivery device to adjust the state of the prosthesis.

[0006] However, during the operation, the protrusion of the control wire is likely to protrude from the connecting shaft in the direction opposite to the direction in which the control wire extends, making it easy for the control wire to get stuck with other parts of the delivery device or certain organs in the human body, thereby increasing the risk of the operation. Summary of the Invention

[0007] An object of the embodiments of the present application is to provide a prosthesis system and a delivery device, which can reduce surgical risks while enabling the delivery device to safely and reliably adjust movable parts in the prosthesis.

[0008] To solve the above problems, an embodiment of the present application provides a prosthesis system, including a delivery device and a prosthesis; the delivery device includes a connecting shaft and a control wire; the prosthesis includes a base and a first movable part, wherein the base is detachably coupled to the connecting shaft; a preset channel, the preset channel is arranged at an angle to the connecting shaft axis on the connecting shaft and / or the base; the control wire has: a first section, a second section and a third section connected in sequence, the size of at least the part of any one of the first section and the third section connected to the second section is larger than the size of the second section, the first section is used to independently drive the first movable part to move, and the second section is accommodated in the preset channel; wherein the preset channel has a first state and a second state, when the preset channel is in the first state, the first section and the third section constrain the second section to the preset channel; when the preset channel is in the second state, the control wire is allowed to separate from the preset channel.

[0009] An embodiment of the present application also provides a conveying device for conveying a prosthesis, the prosthesis including a base and a first movable part; the conveying device including a connecting shaft and a control wire; the connecting shaft and the base are detachably coupled; a preset channel, the preset channel is arranged on the connecting shaft at an angle to the axis of the connecting shaft, or the preset channel is arranged between the connecting shaft and the base at an angle to the axis of the connecting shaft; the control wire has: a first section, a second section and a third section connected in sequence, the size of at least the part of any one of the first section and the third section connected to the second section is larger than the size of the second section, the first section is used to independently drive the first movable part to move, and the second section is accommodated in the preset channel; wherein the preset channel has a first state and a second state, when the preset channel is in the first state, the first section and the third section constrain the second section to the preset channel; when the preset channel is in the second state, the control wire is allowed to separate from the preset channel.

[0010] The prosthesis system and delivery device provided by the embodiments of the present application, when performing a minimally invasive implantation procedure, is placed in a first state so that the first and third sections of the control wire constrain the second section within the preset channel. Subsequently, after the connecting shaft delivers the prosthesis to the target location within the human body through a surgical path such as a natural body cavity, the first section of the control wire can be used to adjust the movement of the first movable part of the prosthesis, thereby changing the state of the prosthesis and enabling implantation. When the delivery device and the prosthesis need to be separated, the preset channel is placed in a second state. In the second state, the control wire is allowed to separate from the preset channel, facilitating separation of the control wire from the prosthesis and subsequent extraction of the control wire from the human body. At this point, the base of the prosthesis can also be disassembled from the connecting shaft of the delivery device, thereby facilitating the withdrawal of the connecting shaft from the human body to complete the implantation procedure. In this way, the delivery device of the prosthesis system can safely and reliably adjust the movable parts in the prosthesis to achieve changes in the prosthesis state, allowing the prosthesis system to safely and reliably complete the procedure.

[0011] Furthermore, because the preset channel in the prosthesis system provided in the embodiments of the present application has a first state and a second state, it cooperates with the control wire to complete the relevant surgical operation. Specifically, when the preset channel is in the first state, the first and third segments constrain the second segment to the preset channel, thereby keeping the second segment within the preset channel and unable to move relative to the preset channel. Furthermore, the first and third segments are prevented from moving relative to the preset channel at their connection points with the second segment, thereby preventing the first and third segments from escaping as in the prior art, thereby avoiding the "control wire easily becoming stuck with other components of the delivery device or certain organs in the human body" as in the prior art, thereby reducing surgical risks.

[0012] In some embodiments, when the preset channel is in a first state, the portion of the preset channel for accommodating the second segment has a first size; the first size is smaller than the size of the portion of either the first segment or the third segment connected to the second segment, and is greater than or equal to the size of the second segment; when the preset channel is in a second state, the portion of the preset channel for accommodating the second segment has a second size; the second size is greater than or equal to the size of the first segment and / or the third segment.

[0013] In some embodiments, the conveying device also includes a center rod; the connecting shaft and / or the base is provided with a accommodating channel arranged axially along the connecting shaft, wherein the accommodating channel intersects with the preset channel, and the area where the accommodating channel and the preset channel overlap is the overlapping area; when the center rod is placed in the accommodating channel and occupies at least part of the overlapping area, the preset channel is in a first state, and the size of the portion in the remaining area of ​​the preset channel for accommodating the second segment is the first size; when the center rod is outside the overlapping area, the preset channel is in a second state, and the size of the portion in the preset channel for accommodating the second segment is the second size.

[0014] In some embodiments, the dimension of the overlapping area occupied by the center rod is the third dimension, the second dimension is greater than or equal to the sum of the third dimension and the dimension of the second segment, and the second dimension is less than the sum of the third dimension and the dimension of the portion of either the first segment and the third segment connected to the second segment.

[0015] In some embodiments, the preset channel is arranged on the connecting shaft; the accommodating channel includes a first accommodating section arranged on the connecting shaft, and the area where the first accommodating section overlaps with the preset channel is the overlapping area; the center rod is placed in the first accommodating section and occupies at least part of the overlapping area, so that the preset channel is in the first state.

[0016] In some embodiments, a preset channel is arranged on the base; the accommodating channel includes a first accommodating section arranged on the connecting shaft, and a second accommodating section arranged on the base, wherein the first accommodating section and the second accommodating section are connected to each other when the base and the connecting shaft are detachably coupled, and the area where the second accommodating section overlaps with the preset channel is the overlapping area; the center rod is placed in the first accommodating section and the second accommodating section and occupies at least part of the overlapping area, so that the preset channel is in the first state.

[0017] In some embodiments, the preset channel is provided at the coupling portion between the connecting shaft and the base; the accommodating path and the preset channel overlap at the coupling portion, and an overlapping area is formed at the overlapping portion.

[0018] In some embodiments, the preset channel is arranged at the coupling point of the connecting shaft and the base; when the connecting shaft and the base are coupled, the preset channel is in a first state, and the preset channel is closed; when the connecting shaft and the base are disassembled, the preset channel is in a second state, and the preset channel is not closed.

[0019] In some embodiments, the connecting shaft has a first contact surface; the base has a second contact surface matching the first contact surface; the first contact surface is provided with a first through groove, and the second contact surface is provided with a second through groove; when the connecting shaft is coupled with the base, the first contact surface cooperates with the second contact surface, and the first through groove and the second through groove together form a closed preset channel; after the connecting shaft and the base are disassembled, the first contact surface and the second contact surface are separated from each other, so that the preset channel is non-closed.

[0020] In some embodiments, the connecting shaft has a first contact surface; the base has a second contact surface matching the first contact surface; the first contact surface or the second contact surface is provided with a third through groove; when the connecting shaft is coupled with the base, the first contact surface cooperates with the second contact surface, and the groove wall of the third through groove and the portion opposite to the other contact surface jointly form a closed preset channel; after the connecting shaft and the base are disassembled, the first contact surface and the second contact surface are separated from each other, so that the preset channel is non-closed.

[0021] In some embodiments, the prosthesis further includes a second movable member; and the third section is configured to independently drive the second movable member to move.

[0022] In some embodiments, the prosthesis is a mitral valve clip or a tricuspid valve clip.

[0023] In some embodiments, the first movable member is a first clamping arm, the second movable member is a second clamping arm, the first clamping arm and the second clamping arm rotate about the axis of the base, and the first section is movably connected to the first clamping arm, and the second section is movably connected to the second clamping arm. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1A schematic diagram of coupling the distal end of a delivery device with a mitral valve clip according to some embodiments of the present application;

[0025] Figure 2 A schematic structural diagram of a mitral valve clip coupled to a delivery device according to some embodiments of the present application during movement of a clamping arm;

[0026] Figure 3 A schematic diagram of the structure of the control wire provided in some embodiments of the present application;

[0027] Figure 4 for Figure 3 A partial enlarged view of part a in the middle;

[0028] Figure 5 A longitudinal cross-sectional view of the control wire, the center rod, and the preset channel provided in some embodiments of the present application;

[0029] Figure 6 A schematic diagram of the structure of the center rod and the preset channel provided in some embodiments of the present application;

[0030] Figure 7 A longitudinal cross-sectional view of the control wire, the center rod and the preset channel provided in other embodiments of the present application;

[0031] Figure 8 A transverse cross-sectional view of the control wire, the center rod, and the preset channel provided in some embodiments of the present application;

[0032] Figure 9 Transverse cross-sectional views of the control wire, the center rod and the preset channel provided in other embodiments of the present application;

[0033] Figure 10 A longitudinal schematic diagram of a connecting shaft and a base provided in some embodiments of the present application cooperating to form a preset channel;

[0034] Figure 11 A longitudinal schematic diagram of a connecting shaft and a base cooperating to form a preset channel provided in other embodiments of the present application;

[0035] Figure 12 A longitudinal cross-sectional view of a connecting shaft and a base provided in other embodiments of the present application cooperating to form a preset channel;

[0036] Figure 13 A simplified schematic diagram of a mitral valve clip clamping a mitral valve leaflet provided in some embodiments of the present application;

[0037] Figure 14 A schematic diagram of the structure of the clamping arm and the control wire provided in some embodiments of the present application when they cooperate;

[0038] Figure 15A schematic diagram of the structure of the clamping arm and the control wire in cooperation with each other according to other embodiments of the present application;

[0039] Figure 16 Schematic diagram of the structure of the clamping arm and the control wire when they cooperate with each other in some other embodiments of the present application. DETAILED DESCRIPTION

[0040] Those skilled in the art will appreciate that, in the various embodiments of this application, many technical details are provided to help readers better understand this application. However, based on various changes and modifications of the following embodiments, the technical solutions claimed in this application can also be implemented.

[0041] In the various embodiments of the present application, "proximal end" and "proximal side" refer to the end closer to the operator and farther from the patient; correspondingly, "distal end" and "distal side" refer to the end closer to the patient and farther from the operator. In the various embodiments of the present application, "parallel" and "perpendicular" should not be narrowly understood as 0° or 90°, but should be understood as including a reasonable angle range with a certain degree of floating from 0° or 90° while achieving the technical effect.

[0042] Some embodiments of the present application provide a prosthesis system, including a delivery device and a prosthesis; the delivery device includes a connecting shaft and a control wire; the prosthesis includes a base and a first movable part, wherein the base is detachably coupled to the connecting shaft; a preset channel, the preset channel is arranged at an angle to the connecting shaft axis on the connecting shaft and / or the base; the control wire has: a first section, a second section and a third section connected in sequence, the size of at least the part of any one of the first section and the third section connected to the second section is larger than the size of the second section, the first section is used to independently drive the first movable part to move, and the second section is accommodated in the preset channel; wherein the preset channel has a first state and a second state, when the preset channel is in the first state, the first section and the third section constrain the second section to the preset channel; when the preset channel is in the second state, the control wire is allowed to separate from the preset channel.

[0043] Some embodiments of the present application provide a prosthesis system in which, during minimally invasive implantation surgery, a predetermined channel is placed in a first state, allowing the first and third sections of the control wire to confine the second section within the predetermined channel. After the connecting shaft delivers the prosthesis to a target location within the human body via a surgical route such as a natural body cavity, the first section of the control wire can be used to adjust the movement of the first movable member of the prosthesis, thereby changing the state of the prosthesis and enabling implantation. When the delivery device needs to be separated from the prosthesis, the predetermined channel is placed in a second state, in which the control wire is allowed to separate from the predetermined channel, facilitating separation of the control wire from the prosthesis and subsequent extraction of the control wire from the human body. At this point, the prosthesis base can also be disassembled from the connecting shaft of the delivery device, facilitating the withdrawal of the connecting shaft from the human body to complete the implantation surgery. In this manner, the delivery device of the prosthesis system can safely and reliably adjust the movable members in the prosthesis to achieve changes in the prosthesis state, enabling the prosthesis system to safely and reliably complete the surgery.

[0044] At the same time, when the preset channel is in the first state, the first section and the third section constrain the second section to the preset channel, so that the second section is always in the preset channel and cannot move relative to the preset channel, and then the connection between the first section and the third section and the second section cannot move relative to the preset channel, so as to avoid the first section and the third section from jumping out of the preset channel as in the prior art, and then avoid the "control wire is easily stuck with other parts of the conveying device or certain organs in the human body" in the prior art, thereby reducing the risk of surgery.

[0045] In order to make the objectives, technical solutions and advantages of this application clearer, the implementation methods of this application will be described in detail below with reference to the accompanying drawings.

[0046] See also Figures 1 to 16 Some embodiments of the present application provide a prosthesis system, comprising: a delivery device 100 and a prosthesis; the delivery device 100 comprises a connecting shaft 110 and a control wire 120; the prosthesis comprises a base 210 and a first movable member, wherein the base 210 is detachably coupled to the connecting shaft 110; a preset channel 300, the preset channel 300 is arranged at an angle to the connecting shaft 110 and / or the base 210 with respect to the axis of the connecting shaft 110; the control wire 120 has: a first section 121, a second section 122 and a third section 123 connected in sequence, the first section 121 and the third section 123 being connected in sequence. The size of at least the portion of any one of the three sections 123 connected to the second section 122 is larger than the size of the second section 122. The first section 121 is used to independently drive the movement of the first movable part, and the second section 122 is accommodated in the preset channel 300; wherein, the preset channel 300 has a first state and a second state. When the preset channel 300 is in the first state, the first section 121 and the third section 123 constrain the second section 122 in the preset channel 300; when the preset channel 300 is in the second state, the control wire 120 is allowed to separate from the preset channel 300.

[0047] Here, the predetermined channel 300 is arranged at an angle to the connecting shaft 110 and / or the base 210, which means that the extending direction of the predetermined channel 300 and the axis of the connecting shaft 110 form an angle greater than 0° and less than 180°, and the predetermined channel 300 is arranged on the connecting shaft 110 and / or the base 210. Preferably, the extending direction of the predetermined channel 300 and the axis of the connecting shaft 110 are perpendicular to each other.

[0048] The fact that at least the portion of either the first segment 121 or the third segment 123 connected to the second segment 122 is larger than the size of the second segment 122 means that the portion of the first segment 121 connected to the second segment 122 is larger than the size of the second segment 122, and the portion of the third segment 123 connected to the second segment 122 is larger than the size of the second segment 122. The term "size" here refers to the cross-sectional dimension perpendicular to the direction of extension. For example, the dimension of the second segment 122 is the cross-sectional dimension of the second segment 122 perpendicular to the direction of extension of the second segment 122. If the cross section of the control wire 120 is circular, the dimension of the control wire 120 is the diameter of the cross section of the control wire 120. In one embodiment, the dimension of the second segment 122 is the diameter of the second segment 122. If the cross section of the control wire 120 is non-circular, the dimension of the control wire 120 is a dimension determined according to a specific rule, such as twice the distance from the geometric center of the cross section to a point on the cross section. In one embodiment, the dimension of the second segment 122 is the diameter of the circumcircle of the second segment 122.

[0049] like Figure 8 In some embodiments, to facilitate manufacturing of the control wire 120, the dimensions of the first segment 121 are uniform throughout, and the dimensions of the third segment 123 are uniform throughout. Specifically, the dimensions of the remaining portions of the first segment 121 are equal to the dimensions of the portion connecting the first segment 121 and the second segment 122, and the dimensions of the remaining portions of the third segment 123 are equal to the dimensions of the portion connecting the third segment 123 and the second segment 122. Furthermore, in this embodiment, the dimensions of the second segment 122 may also be uniform throughout.

[0050] like Figure 9 In some further embodiments, the size of the portion where the first segment 121 is connected to the second segment 122 is larger than the size of the second segment 122, while the size of the other portions of the first segment 121 is smaller than the size of the portion where the first segment 121 is connected to the second segment 122; correspondingly, the size of the portion where the third segment 123 is connected to the second segment 122 is larger than the size of the second segment 122, while the size of the other portions of the third segment 123 is smaller than the size of the portion where the third segment 123 is connected to the second segment 122.

[0051] In some embodiments, the first movable member is movably disposed on the base 210. The first movable member being movably disposed on the base 210 means that the first movable member is directly and movably connected to the base 210, or the first movable member is movably connected to the base 210 through other components, which is not limited in this application.

[0052] In some embodiments, since the first section 121 needs to control the movement of the first movable member, the control wire 120 is made of a rigid material with a large elastic modulus, such as medical stainless steel, titanium alloy, etc.

[0053] Furthermore, the preset channel 300 and the control wire 120 are configured with respect to each other in size so that when the preset channel 300 is in the first state, the first section 121 and the third section 123 cannot pass through the preset channel 300 and can only be adjacent to the preset channel 300, while the second section 122 is confined within the preset channel 300; when the preset channel 300 is in the second state, the control wire 120 is allowed to separate from the preset channel 300.

[0054] In some embodiments, the size of the preset channel 300 in the first state is different from the size of the preset channel 300 in the second state. Specifically, when the preset channel 300 is in the first state, the portion of the preset channel 300 that accommodates the second segment 122 has a first size; the first size is smaller than the size of the portion of either the first segment 121 or the third segment 123 that connects to the second segment 122, and is greater than or equal to the size of the second segment 122. When the preset channel 300 is in the second state, the portion of the preset channel 300 that accommodates the second segment 122 has a second size; the second size is greater than the size of the first segment 121 and / or the third segment 123.

[0055] In some embodiments, “a first dimension of a portion of the preset channel 300 for accommodating the second segment 122 when the preset channel 300 is in the first state” refers to the cross-sectional dimension of the portion of the preset channel 300 for accommodating the second segment 122 of the control wire 120, perpendicular to the extending direction of the preset channel 300, when the preset channel 300 is in the first state. Correspondingly, “a second dimension of a portion of the preset channel 300 for accommodating the second segment 122 when the preset channel 300 is in the second state” refers to the cross-sectional dimension of the portion of the preset channel 300 for accommodating the second segment 122 of the control wire 120, perpendicular to the extending direction of the preset channel 300, when the preset channel 300 is in the second state.

[0056] Since the first dimension of the preset channel 300 and the dimensions of the control wire 120 are configured such that the first dimension is smaller than the dimension of the portion of either the first section 121 or the third section 123 connected to the second section 122, and is larger than or equal to the dimension of the second section 122, the second section 122 can be accommodated within the preset channel 300 in the first state by virtue of the dimension of the second section 122 being smaller than or equal to the first dimension; the dimension of the portion of the first section 121 connected to the second section 122 being larger than the first dimension prevents the first section 121 from passing through the preset channel 300 in the first state; and the dimension of the portion of the third section 123 connected to the second section 122 being larger than the first dimension prevents the third section 123 from passing through the preset channel 300 in the first state, thereby constraining the second section 122 accommodated within the preset channel 300.

[0057] At the same time, the second dimension of the preset channel 300 and the dimension of the control wire 120 are configured such that the second dimension is greater than or equal to the dimension of the first segment 121 and / or the third segment 123. Therefore, the dimension of the first segment 121 at all locations along its extension direction is smaller than the second dimension, and / or the dimension of the third segment 123 at all locations along its extension direction is smaller than the second dimension, so that the control wire 120 can move within the preset channel 300 in the second state and can be separated from the preset channel 300.

[0058] In this way, when the preset channel 300 is in the first state, the first section 121 and the third section 123 cannot pass through the preset channel 300, so that the second section 122 is constrained in the preset channel 300; and when the preset channel 300 is in the second state, the preset channel 300 allows the control wire 120 to detach from the preset channel 300.

[0059] In some embodiments, the length of the second segment 122 is the same as the length of the predetermined channel 300. This allows the end of either the first segment 121 or the third segment 123 connected to the second segment 122 to be positioned adjacent to an end of the predetermined channel. This allows the first segment 121 and the third segment 123 to be positioned outside the predetermined channel 300, respectively, facilitating precise control of the prosthesis's movable parts by the control wire 120. In this case, the predetermined channel 300 is used only to accommodate the second segment 122.

[0060] Alternatively, the length of the second section 122 may be shorter than the length of the predetermined channel 300. In this case, the connection between at least one of the first section 121 and the third section 123 and the second section 122 may be within the predetermined channel 300. That is, the predetermined channel 300 accommodates both the second section 122 and a portion of the first section 121 and / or the third section 123.

[0061] In some embodiments, the delivery device 100 further includes a central rod 130, and the size of the preset channel 300 is adjusted by controlling whether the central rod 130 overlaps with the preset channel 300. Specifically, the connecting shaft 110 and / or the base 210 are provided with an accommodating channel arranged axially along the connecting shaft 110, wherein the accommodating channel intersects with the preset channel 300, and the area where the accommodating channel and the preset channel 300 overlap is the overlapping area; when the central rod 130 is placed in the accommodating channel and occupies at least part of the overlapping area, the preset channel 300 is in a first state, and the size of the portion of the preset channel 300 used to accommodate the second segment 122 in the remaining area is the first size; when the central rod 130 is located outside the overlapping area, the preset channel 300 is in a second state, and the size of the portion of the preset channel 300 used to accommodate the second segment 122 is the second size.

[0062] In this way, the second size can be made larger than the first size, so as to facilitate satisfying that the first size is smaller than the size of the part of any one of the first segment 121 and the third segment 123 connected to the second segment 122, and is greater than or equal to the size of the second segment 122, and the second size is larger than the size of the first segment 121 and / or the third segment 123.

[0063] In some embodiments, the preset channel 300 can be switched from the first state to the second state. Further, when the preset channel 300 needs to be switched from the first state to the second state, it can be achieved by simply positioning the central rod 130 outside the overlapped area.

[0064] In some embodiments, the dimension of the overlapping area occupied by the center rod 130 is the third dimension, the second dimension is greater than or equal to the sum of the third dimension and the dimension of the second segment 122, and the second dimension is less than the sum of the third dimension and the dimension of the portion of either the first segment 121 or the third segment 123 connected to the second segment 122.

[0065] In some embodiments, the preset channel 300 is arranged on the connecting shaft 110, and the accommodating channel includes a first accommodating section 410 arranged on the connecting shaft 110, and the area where the first accommodating section 410 overlaps with the preset channel 300 is the overlapping area; the center rod 130 is placed in the first accommodating section 410 and occupies at least part of the overlapping area, so that the preset channel 300 is in the first state.

[0066] In one embodiment, the size of the overlapping area is smaller than the second size.

[0067] For details, see Figure 5 and Figure 6In one example, the accommodating channel includes a first accommodating section 410 disposed on the connecting shaft 110 to accommodate the center rod 130; a predetermined channel 300 is disposed on the connecting shaft 110, and the predetermined channel 300 forms a straight groove 301 on the inner wall of the connecting shaft 110, and further forms a first wall hole 302 on the connecting shaft 110, which is opposite to the straight groove 301. The first accommodating section 410 and the predetermined channel 300 partially overlap, and the area corresponding to the first wall hole 302 is the overlapping area. When the center rod 130 is placed in the first accommodating section 410 and occupies at least part of the overlapping area, the predetermined channel 300 is in a first state, and the space of the predetermined channel 300 is defined by the straight groove 301 and the portion of the outer surface of the center rod 130 corresponding to the straight groove 301. When the center rod 130 does not occupy the overlapping area, the preset channel 300 is in the second state. At this time, the straight groove 301 and the first wall hole 302 can both accommodate the control wire 120, and the space of the preset channel 300 is limited by the straight groove 301 and the first wall hole 302.

[0068] In yet another embodiment, the size of the overlapping area is equal to the second size.

[0069] For details, see Figure 7 In one example, similar to the above-described embodiment, the accommodating channel includes a first accommodating section 410 disposed on the connecting shaft 110 to accommodate the center rod 130; a predetermined channel 300 is disposed on the connecting shaft 110. The difference is that the predetermined channel 300 forms a second wall hole 303 on the connecting shaft 110 that extends through the connecting shaft 110. The first accommodating section 410 and the predetermined channel 300 overlap, and the second wall hole 303 is the overlapping area. The center rod 130 is smaller than the first accommodating section 410, so the center rod 130 can only occupy a portion of the overlapping area. Consequently, the second wall hole 303 is divided into a first hole wall portion 3032 that can be occupied by the center rod 130 and a second hole wall portion 3031 that cannot be occupied by the center rod 130. When the center rod 130 is placed in the first accommodating section 410 and occupies a portion of the overlapping area, the predetermined channel 300 is in a first state, where the space within the predetermined channel 300 is defined by the second hole wall portion 3031 and the corresponding portion of the outer surface of the center rod 130. When the center rod 130 does not occupy the overlapping area, the preset channel 300 is in the second state. At this time, the first hole wall portion 3032 and the second hole wall portion 3031 can accommodate the control wire 120, and the space of the preset channel 300 is limited by the first hole wall portion 3032 and the second hole wall portion 3031, that is, the second wall hole 303.

[0070] Alternatively, the preset channel 300 may also be provided on the base 210. Specifically, the accommodating channel includes a first accommodating section 410 provided on the connecting shaft 110, and a second accommodating section provided on the base 210, wherein the first accommodating section 410 and the second accommodating section are interconnected when the base 210 and the connecting shaft 110 are detachably coupled, and the area where the second accommodating section overlaps with the preset channel 300 is the overlapping area. When the center rod 130 is placed in the first accommodating section 410 and the second accommodating section and occupies at least part of the overlapping area, the preset channel 300 is in the first state. It should be noted that the specific embodiment of the preset channel 300 being provided on the base 210 may be the same as the specific embodiment of the preset channel 300 being provided on the connecting shaft 110 in the above-mentioned embodiment, and will not be repeated here.

[0071] Alternatively, the predetermined channel 300 can be disposed at the coupling between the connecting shaft 110 and the base 210. Specifically, the accommodating channel and the predetermined channel 300 overlap at the coupling between the connecting shaft 110 and the base 210, forming an overlapping region at the overlapping region. The central rod 130 is placed within the accommodating channel and extends to the coupling between the connecting shaft 110 and the base 210, occupying at least a portion of the overlapping region, placing the predetermined channel 300 in the first state.

[0072] In some embodiments, the cross-sectional shape of the preset channel 300 in the first state is different from the cross-sectional shape of the preset channel 300 in the second state. Specifically, the preset channel 300 is disposed at the coupling portion between the connecting shaft 110 and the base 210. When the connecting shaft 110 and the base 210 are coupled, the preset channel 300 is in the first state, in which the preset channel 300 is closed. The dimensions of the closed preset channel 300 match the second section 122 to constrain the control wire 120. When the connecting shaft 110 and the base 210 are disassembled, the preset channel 300 is in the second state, in which the preset channel 300 is open, i.e., the preset channel 300 has a gap that allows the second section 122 to be disengaged.

[0073] In this way, when the preset channel 300 is in the first state, the first section 121 and the third section 123 cannot pass through the preset channel 300, and the second section 122 is restricted in the preset channel 300; and when the preset channel 300 is in the second state, the second section 122 can be separated from the preset channel 300 from the gap of the preset channel 300, so that the control wire 120 is free from the restriction of the preset channel 300.

[0074] It should be noted that the preset channel 300 is closed, which means that the shape of the preset channel 300 in its circumferential direction is closed; the preset channel 300 is non-closed, which means that the shape of the preset channel 300 in its circumferential direction is divided into two non-closed parts.

[0075] In some embodiments, the connecting shaft 110 has a first contact surface 111; the base 210 has a second contact surface 211 matching the first contact surface 111; the first contact surface 111 is provided with a first through groove 112, and the second contact surface 211 is provided with a second through groove 212; when the connecting shaft 110 is coupled with the base 210, the first contact surface 111 and the second contact surface 211 cooperate with each other, and the first through groove 112 and the second through groove 212 jointly form a closed preset channel 300; after the connecting shaft 110 and the base 210 are disassembled, the first contact surface 111 and the second contact surface 211 are separated from each other, so that the preset channel 300 is non-closed.

[0076] For details, see Figure 10 In one example, the first contact surface 111 includes a first distal blocking surface 1111 at the distal end, a first inclined surface 1112 extending from near to far, and a first proximal blocking surface 1113 at the proximal end; the second contact surface 211 includes a second distal blocking surface 2111 at the distal end, a second inclined surface 2112 extending from near to far, and a second proximal blocking surface 2113 at the proximal end. The first through-slot 112 is provided on the first inclined surface 1112 adjacent to the first proximal blocking surface 1113. The second through-slot 212 is provided on the second inclined surface 2112 adjacent to the second proximal blocking surface 2113. The first through-slot 112 includes a first slot wall and a first slot opening. The second through-slot 212 includes a second slot wall and a second slot opening. The cross-sections of the first slot wall and the second slot wall are both arc-shaped, preferably circular arc-shaped. When the connecting shaft 110 is coupled to the base 210, the first distal blocking surface 1111 and the second distal blocking surface 2111 are aligned, the first inclined surface 1112 and the second inclined surface 2112 are aligned, and the first proximal blocking surface 1113 and the second proximal blocking surface 2113 are aligned. The first through slot 112 and the second through slot 212 form a preset channel 300 in a closed state.

[0077] In this way, when the first notch of the first through-slot 112 is aligned with the second notch of the second through-slot 212, the first groove wall of the first through-slot 112 and the second groove wall of the second through-slot 212 constitute the sidewalls of the closed preset channel 300. When the connecting shaft 110 is disassembled from the base 210, the first through-slot 112 and the second through-slot 212 are separated, so that the first notch of the first through-slot 112 and the second notch of the second through-slot 212 no longer are aligned. The first groove wall of the first through-slot 112 and the second groove wall of the second through-slot 212, which constitute the sidewalls of the preset channel 300, are separated, and the preset channel 300 is thus in an open state.

[0078] In yet other embodiments, the connecting shaft 110 has a first contact surface 111; the base 210 has a second contact surface 211 that matches the first contact surface 111; and a third through-slot 113 is provided on either the first contact surface 111 or the second contact surface 211. When the connecting shaft 110 and the base 210 are coupled, portions of the first contact surface 111 and the second contact surface 211 abut against each other, and the walls of the third through-slot 113 and the portion of the third through-slot opposite the other contact surface together form a closed, predetermined passage 300. After the connecting shaft 110 and the base 210 are disassembled, the first contact surface 111 and the second contact surface 211 separate from each other, rendering the predetermined passage 300 non-closed. This differs from the above embodiments in that a through-slot is provided on either the first contact surface 111 or the second contact surface 211.

[0079] For details, see Figure 11 In one example, the first contact surface 111 includes a third distal blocking surface 1114 at the distal end, a third inclined surface 1115 extending from proximal to distal, and a third proximal blocking surface 1116 at the proximal end. The second contact surface 211 includes a fourth distal blocking surface 2114 at the distal end, a fourth inclined surface 2115 extending from proximal to distal, a fourth proximal blocking surface 2116 at the proximal end, and a transition surface 2117 between the fourth inclined surface 2115 and the fourth proximal blocking surface 2116. The third through-slot 113 is provided on the third inclined surface 1115 near the third proximal blocking surface 1114, corresponding to the transition surface 2117. The third through-slot 113 includes a third slot wall and a third notch. The cross-section of the third slot wall is arc-shaped, preferably circular. When the connecting shaft 110 is coupled to the base 210, the third distal blocking surface 1114 and the fourth distal blocking surface 2114 are aligned, the third inclined surface 1115 and the fourth inclined surface 2115 are aligned, and the third proximal blocking surface 1116 and the fourth proximal blocking surface 2116 are aligned. The third through slot 113 and the transition surface 2117 form a preset channel 300 in a closed state.

[0080] Thus, when the third notch of the third through-slot 113 is in contact with the transition surface 2117, the third groove wall of the third through-slot 113 and the transition surface 2117 form the sidewalls of the closed predetermined channel 300. When the connecting shaft 110 is disassembled from the base 210, the third through-slot 113 separates from the transition surface 2117, so that the third notch of the third through-slot 113 no longer is in contact with the transition surface 2117. The third groove wall of the third through-slot 113, which forms the sidewalls of the predetermined channel 300, separates from the transition surface 2117, and thus the predetermined channel 300 becomes open.

[0081] Alternatively, in yet another example, the first contact surface 111 includes a transition surface between the third inclined surface and the third proximal blocking surface, and the second contact surface 211 no longer has a transition surface. Instead, a fourth through-slot is provided at a location corresponding to the transition surface of the first contact surface 111. When the connecting shaft 110 is coupled to the base 210, the fourth through-slot and the transition surface form a closed predetermined passage 300. When the connecting shaft 110 and the base 210 are disassembled, the fourth through-slot and the transition surface separate, and the predetermined passage 300 becomes open.

[0082] In yet another alternative embodiment, the connecting shaft 110 includes a first coupling portion 114, and the base 210 includes a second coupling portion 213. The first coupling portion 114 or the second coupling portion 213 is axially offset. When the first coupling portion 114 or the second coupling portion 213 is driven axially, the first coupling portion 114 and the second coupling portion 213 are coupled. The first contact surface 115 is located on the side of the first coupling portion 114 facing the second coupling portion 213, and the second contact surface 214 is located on the side of the second coupling portion 213 facing the first coupling portion 114. In this embodiment, as in the above embodiment, two through-slots forming the predetermined channel 300 can be provided, one on the first contact surface 115 and the other on the second contact surface 214. Alternatively, the predetermined channel 300 can be formed by a single through-slot provided on the first contact surface 115 or the second contact surface 214.

[0083] Furthermore, one of the first coupling part 114 and the second coupling part 214 includes a protrusion 116, and the other includes a groove 215; wherein the first coupling part 114 or the second coupling part 213 is arranged axially offset so that the protrusion 116 is separated from the groove 215; when the first coupling part 114 or the second coupling part 213 is driven to be arranged axially, the protrusion 116 is accommodated in the groove 215.

[0084] The following description will be made by taking as an example a through groove constituting the preset channel 300 and provided on the first contact surface 115. Specifically, Figure 12As shown, in one example, the first coupling portion 114 also includes an inwardly biased support member 117 and a fifth through slot 118, the protrusion 116 is located at the distal end of the support member 117 and extends perpendicular to the axial direction of the support member 117, the fifth through slot 118 is arranged on the support member 117, and the fifth through slot 118 includes a fifth notch and a fifth slot wall; the groove 215 is arranged on the inner wall of the base 210; the conveying device 100 also includes a center rod 130, the center rod 130 is movably arranged in the connecting shaft 110, when the first coupling portion 114 needs to be coupled with the second coupling portion 213, the center rod 130 moves distally and passes through the first coupling portion 114 and the second coupling portion 213, so that the support member 114 is driven to deflect until the axis of the support member 114 is parallel to the axis of the connecting shaft 110, and the protrusion 116 is accommodated in the groove 215. At this time, the fifth through-slot 118 and the inner wall of the second coupling portion 213 form a closed predetermined channel 300. That is, the fifth notch 118 is attached to the inner wall of the second coupling portion 213, and the fifth slot wall 118 and the inner wall of the second coupling portion 213 form the side walls of the predetermined channel 300. When the connecting shaft 110 is disassembled from the base 210, the fifth through-slot 118 separates from the inner wall of the second coupling portion 213, and the predetermined channel 300 becomes open.

[0085] In some embodiments, the prosthesis includes a movable part, namely a first movable part. By controlling the movement of the first movable part through the first section 121, a change in the state of the prosthesis can be achieved. The "state" here can be a change in the structure or shape of the prosthesis as a whole or in part, such as from a compressed state to an expanded state, and another example is to achieve an unlocked state, a locked state between the prosthesis and the target tissue, between the prosthesis and the delivery system, and between the internal components of the prosthesis, and / or a change from a locked state to an unlocked state; the "state" can also be a change in the position and / or posture of the prosthesis as a whole or in part (such as the first movable part). For example, a stent graft used to treat aortic stenosis generally uses a restraining wire (i.e., the first movable part) to restrain the stent graft in a compressed state during delivery. When the stent graft is positioned at the target position, the restraining wire is released by the control wire to achieve the stent graft from a compressed state to an expanded state.

[0086] In other embodiments, the prosthesis includes two movable parts, namely a first movable part and a second movable part. The first section 121 controls the movement of the first movable part, while the third section 123 controls the movement of the second movable part to achieve changes in the prosthesis state. When it is necessary to separate the delivery device 100 from the prosthesis, the preset channel 300 can be placed in the second state, thereby allowing the control wire 120 to be disengaged from the preset channel 300, facilitating the extraction of the control wire 120 from the human body and separation from the prosthesis. In this way, the movement of the two movable parts of the prosthesis (i.e., the first movable part and the second movable part) can be controlled by a single control wire 120.

[0087] In some embodiments, the prosthesis is a mitral valve clip 200 for treating mitral regurgitation. It should be emphasized that the prosthesis being the mitral valve clip 200 is merely an example. In other embodiments, the prosthesis may not be the mitral valve clip 200. This application does not limit the specific type of prosthesis.

[0088] like Figure 13 As shown, the mitral valve clip 200 includes a base 210, a clamping arm (i.e., a movable member), and a clamping seat. The clamping arm and the clamping seat are rotatable relative to the axis of the base 210. The clamping arm is located at the proximal end of the base 210, and the clamping seat is located at the distal end of the base 210. In this embodiment, the clamping arm includes a first clamping arm 220 (i.e., a first movable member) and a second clamping arm 230 (i.e., a second movable member), which are arranged symmetrically about the axis of the base 210.

[0089] It should be emphasized that the first movable part here is the first clamping arm 220, and the second movable part is the second clamping arm 230, which is only an example when the prosthesis is the mitral valve clip 200. In other embodiments, the first movable part may not be the first clamping arm 220, and the second movable part may not be the second clamping arm 230. The present application does not limit the specific types of the first movable part and the second movable part.

[0090] Similarly, the clamping seat includes a first clamping seat 240 and a second clamping seat 250, which are arranged symmetrically about the axis of the base 210 and located in the plane where the first clamping arm 220 and the second clamping arm 230 are located, thereby better clamping the edges of the anterior and posterior leaflets of the mitral valve 400. Here, "the plane where the first clamping arm 220 and the second clamping arm 230 are located" refers to the plane formed by the axis of the first clamping arm 220 and the axis of the second clamping arm 230; and "the first clamping seat 240 and the second clamping seat 250 are located in the plane where the first clamping arm 220 and the second clamping arm 230 are located" means that the axes of the first clamping seat 240 and the second clamping seat 250 are both located in the plane where the first clamping arm 220 and the second clamping arm 230 are located. After the mitral valve clip 200 is delivered to the target mitral valve position, the clamping arms and the clamping seat are driven to rotate to clamp the anterior and posterior leaflets of the mitral valve 400 between the clamping arms and the clamping seat, thereby achieving treatment for mitral regurgitation. Here, the mitral valve clip is replaced by a tricuspid valve clip to treat tricuspid regurgitation.

[0091] Specifically, see Figure 1 、 Figure 2 and Figure 15In one example, the first clamping arm 220 and the second clamping arm 230 are both sheet-shaped, and the first clamping arm 220 and the second clamping arm 230 are elastically connected by the transition portion 102. Furthermore, the transition portion 102 is provided at the distal end of the base 210. Preferably, the first clamping arm 220, the transition portion 102 and the second clamping arm 230 are integrally formed to form a shape similar to an inverted Ω. Moreover, the first clamping arm 220 and the second clamping arm 230 are in an extended state in a natural state. Figure 2 As shown, when the first section 121 is pulled, the first clamping arm 220 is driven to rotate upward and toward the base 210, and the first clamping arm 220 undergoes elastic deformation. When the first section 121 is pushed, the first clamping arm 220 rotates away from the base 210, returning to its original shape. Correspondingly, when the third section 123 is pulled, the second clamping arm 230 is driven to rotate upward and toward the base 210, and the second clamping arm 230 undergoes elastic deformation. When the third section 123 is pushed, the second clamping arm 230 rotates away from the base 210, returning to its original shape.

[0092] Continue to see Figure 1 and Figure 2 , the first clamping seat 240 and the second clamping seat 250 are both rotatably connected to the base 210. Preferably, the first clamping seat 240 and the second clamping seat 250 are rotatably connected to the base 210 via the same rotating shaft. Preferably, the cross-sectional shape of the first clamping seat 240 perpendicular to the axial direction is U-shaped, so as to better wrap the edge 401 of the first leaflet of the mitral valve and the first clamping arm 220. Similarly, the cross-sectional shape of the second clamping seat 250 perpendicular to the axial direction is U-shaped, so as to better wrap the edge 402 of the second leaflet of the mitral valve and the second clamping arm 230. When the mitral valve clip 200 clamps the mitral valve leaflet, the first clamping seat 240 and the second clamping seat 250 are driven to rotate and squeeze the edge of the mitral valve leaflet and the first clamping arm 220 and the second clamping arm 230, so as to achieve the clamping of the mitral valve leaflet by the mitral valve clip 200.

[0093] This embodiment does not specifically limit the manner in which the first segment 121 controls the movement of the first movable member and the third segment 123 controls the movement of the second movable member. For the mitral valve clip 200, it is sufficient for the first segment 121 to be movably connected to the first clamping arm 220. This allows, on the one hand, the first clamping arm 220 to rotate with the movement of the first segment 121; on the other hand, when the delivery device 100 needs to be separated from the mitral valve clip 200, the control wire 120 can be separated from the first clamping arm 220. The relationship between the third segment 123 and the second clamping arm 230 is similar and will not be further described.

[0094] In some embodiments, as Figure 2 、 3As shown, the first section 121 extends distally from the predetermined channel 300, and after reaching the location of the first clamping arm 220, it extends in the opposite direction toward the proximal end of the delivery device 100. Thus, the first section 121 forms a curved portion at the location of the first clamping arm 220. The curved portion interpenetrates with the first clamping arm 220 or an accessory disposed on the first clamping arm 220 to facilitate control of the rotation of the first clamping arm 220.

[0095] In this embodiment, the second section 122 and the third section 123 are both configured to be detachable from the first clamping arm 220. In this way, when the control wire 120 needs to be pulled away from the first clamping arm 220, the third section 123 and the second section 122 can be pulled away from the first clamping arm 220.

[0096] Preferably, in this embodiment, the connection between the third section 123 and the second section 122 forms a first transition portion 124, and the cross-sectional area of ​​the first transition portion 124 gradually increases in the direction from the second section 122 to the third section 123. Thus, while the size of the second section 122 is smaller than or equal to the first size so that the second section 122 can be placed within the preset passage 300 in the first state, the size of the third section 123, at least where it connects to the second section 122, can be larger than the first size so that the third section 123 cannot pass through the preset passage 300 in the first state. Furthermore, the connection between the second section 122 and the third section 123 forms a smooth transition at the first transition portion 124, so that there is no obvious protrusion at the connection between the second section 122 and the third section 123.

[0097] In this way, when the control wire 120 is withdrawn and the entire control wire 120 is removed from the first clamping arm 220, the second section 122 and the third section 123 can be withdrawn from the first clamping arm 220 relatively smoothly and sequentially, thereby avoiding affecting the posture and / or position of the first clamping arm 220. In addition, by providing the first transition portion 124 with a smooth transition, the control wire 120 can be prevented from getting stuck on other components of the prosthetic system during withdrawal, and the control wire 120 can also be prevented from being worn, thereby reducing the possibility of the control wire 120 breaking.

[0098] See also Figure 14 In some embodiments, the above-mentioned accessory is a fixing line 223, which is set on the first clamping arm 220 by bundling, knotting, etc., and the fixing line 223 forms a body 226 for interpenetrating with the curved portion of the first section 121.

[0099] Specifically, the body 226 is annular to form a first through hole for interpenetrating with the curved portion. The fixing line 223 further includes a fixing knot 225 connected to the body 226. The fixing knot 225 is provided on the first clamping arm 220. The curved portion of the first section 121 passes through the first through hole to interpenetrate with the body 226.

[0100] Furthermore, the first clamping arm 220 is provided with a second through hole 224 on its surface, the main body 226 passes through the second through hole 224 from the side of the first clamping arm 220 away from the base 210, and the fixing knot 225 is arranged on the side of the first clamping arm 220 away from the base 210, and the fixing knot 225 is configured to be unable to pass through the second through hole 224.

[0101] Alternatively, the fixing knot 225 of the fixing wire 223 is wrapped around the second through hole 224 to be fixedly connected to the first clamping arm 220 .

[0102] See also Figure 15 In some further embodiments, the first clamping arm 220 is provided with two third through holes 221. The end of the first section 121 away from the second section 122 (i.e., the end of the curved portion) passes through one third through hole 221 from the side of the first clamping arm 220 away from the first clamping seat 240, and then passes through the other third through hole 221 from the side of the first clamping arm 220 closer to the first clamping seat 240. In this way, the curved portion of the first section 121 and the first clamping arm 220 can interpenetrate.

[0103] Alternatively, the first clamping arm 220 is provided with an even number of third through holes 221, greater than two, and the end of the first section 121 away from the second section 122 (i.e., the end of the curved portion) alternately passes through these third through holes 221. In this way, the curved portion of the first section 121 can also interpenetrate with the first clamping arm 220.

[0104] See also Figure 16 In yet other embodiments, the first clamping arm 220 is provided with a protrusion 101, and the protrusion 101 on the first clamping arm 220 is provided with a fourth through-hole 227. The end of the first segment 121 away from the second segment 122 (i.e., the end of the curved portion) passes through the fourth through-hole 227. This allows the curved portion of the first segment 121 to interpenetrate the first clamping arm 220. Preferably, the fourth through-hole 227 extends in the same direction as the first clamping arm 220.

[0105] It should be noted that the connection between the third section 123 and the second clamping arm 230 can be referred to the connection between the first section 121 and the first clamping arm 220, and will not be repeated here. In addition, preferably, the connection between the first section 121 and the second section 122 can be a second transition portion 125 having the same function as the first transition portion 124, and will not be repeated here.

[0106] In addition, in one example, the first section 121 and the second section 122 can also be configured to be detachable from the second clamping arm 230. In this way, when the control wire 120 needs to be pulled away from the second clamping arm 230, it can be ensured that the first section 121 and the second section 122 can be pulled away from the second clamping arm 230.

[0107] Furthermore, the mitral valve clip 200 further includes an actuating assembly for controlling the rotation of the first clamping seat 240 and the second clamping seat 250 .

[0108] Continue to refer Figure 1 、 Figure 2 The actuating assembly includes a first connecting rod 261, a second connecting rod 262, and a slider 263. The proximal end of the first connecting rod 261 is rotatably connected to the first clamping seat 240, and the distal end is rotatably connected to the slider 263. The slider 263 is axially movable relative to the base 210. Thus, the first connecting rod 261, the first clamping seat 240, the base 210, and the slider 263 form a motion mechanism similar to a slider-crank mechanism. When the slider 263 is driven toward or away from the base 210, the first clamping seat 240 is driven to rotate. Similarly, the proximal end of the second connecting rod 262 is rotatably connected to the second clamping seat 250, and the distal end is rotatably connected to the slider 263. Similarly, the second connecting rod 262, the second clamping seat 250, the base 210, and the slider 263 also form a motion mechanism similar to a slider-crank mechanism. When the slider 263 is driven toward or away from the base 210, the second clamping seat 250 is driven to rotate.

[0109] Furthermore, the slider 263 is in a "T" shape, that is, the slider 263 includes a horizontal portion and a vertical portion. The two ends of the horizontal portion of the slider 263 are rotatably connected to the first connecting rod 261 and the second connecting rod 262 respectively, and the vertical portion of the slider 263 is detachably connected to the center rod 160, for example, by a threaded connection. In this way, the slider 263 can be driven to move by the center rod 160 to rotate the first clamping seat 240 and the second clamping seat 250. Preferably, the first connecting rod 261 and the second connecting rod 262 are symmetrically arranged about the axis of the base 210. In this way, when the slider 263 drives the first clamping seat 240 and the second clamping seat 250 to move, the rotation angle of the first clamping seat 240 is the same as the rotation angle of the second clamping seat 250.

[0110] Preferably, the delivery device 100 further comprises a catheter 140 sleeved on the connecting shaft 110, the catheter 140 being provided with two second channels extending axially along the catheter 140; the end of the first section 121 remote from the second section 122 extending from the distal end of one second channel through the second channel to the proximal end of the second channel, and the end of the third section 123 remote from the second section 122 extending from the distal end of the other second channel through the second channel to the proximal end of the second channel. This facilitates an operator to adjust the rotation angle of the first clamping arm 220 by lifting the end of the first section 121 remote from the second section 122 at the proximal end of the catheter 140, and facilitates an operator to adjust the rotation angle of the second clamping arm 230 by lifting the end of the third section 123 remote from the second section 122 at the proximal end of the catheter 140. When it is necessary to separate the control wire 120 from the mitral valve clip 200, the preset channel is adjusted to the second state, and the operator pulls the first section 121 away from one end of the second section 122 or pulls the third section 123 away from one end of the second section 122 at the proximal end of the catheter 140 to separate the control wire 120 from the mitral valve clip 200.

[0111] It should be noted that the present application does not limit the specific embodiment of the detachable coupling between the connecting shaft 110 and the base 210. In addition to the method provided in the above embodiment, any other suitable method can also be used, such as the figure in the specification of US Patent Document US20210145574A1. Figure 5 A, 5B, as shown in the accompanying drawings of the specification in US Patent Document US20210145574A1 Figure 6 Methods A and 6B are also like the methods of Figures 82A and 82B in the specification of Chinese patent document CN102395331B, and can also be like the method of Figure 84 in the specification of Chinese patent document CN102395331B.

[0112] Continue to see Figures 1 to 16Some other embodiments of the present application further provide a delivery device 100 for delivering a prosthesis, the prosthesis comprising a base 210 and a first movable member, the delivery device 100 comprising a connecting shaft 110 and a control wire 120; the connecting shaft 110 and the base 210 are detachably coupled; a preset channel 300, the preset channel 300 being arranged at an angle to the axis of the connecting shaft 110 on the connecting shaft 110, or the preset channel 300 being arranged at an angle to the axis of the connecting shaft 110 between the connecting shaft 110 and the base 210; the control wire 120 having: a first section 121, a second section 122, and a first section 123 connected in sequence. There are three sections 123, and the size of at least the portion of any one of the first section 121 and the third section 123 connected to the second section 122 is larger than the size of the second section 122. The first section 121 is used to independently drive the first movable part to move, and the second section 122 is accommodated in the preset channel 300; wherein, the preset channel 300 has a first state and a second state. When the preset channel 300 is in the first state, the first section 121 and the third section 123 constrain the second section 122 in the preset channel 300; when the preset channel 300 is in the second state, the control wire 120 is allowed to separate from the preset channel 300.

[0113] In fact, the conveying device 100 provided in this embodiment has the same structure and beneficial effects as the partial conveying device 100 provided in the other embodiments mentioned above (the partial conveying device 100 here refers to the conveying device 100 including a connecting shaft 110 with a preset channel, or the conveying device 100 including a preset channel between the connecting shaft 110 and the base 210), which will not be repeated here.

[0114] Those skilled in the art will appreciate that the above-described embodiments are specific examples for implementing the present application, and that in actual applications, various changes in form and detail may be made thereto without departing from the spirit and scope of the present application. Any person skilled in the art may make changes and modifications without departing from the spirit and scope of the present application. Therefore, the scope of protection of the present application shall be subject to the scope defined in the claims.

Claims

1. A prosthesis system, characterized in that: including a delivery device and a prosthesis; The conveying device includes a connecting shaft and a control wire; The prosthesis includes a base and a first movable member, wherein the base is detachably coupled to the connecting shaft; A preset channel is provided at the coupling portion between the connecting shaft and the base and is arranged at an angle to the axis of the connecting shaft; The control wire comprises a first section, a second section, and a third section connected in sequence. The size of at least the portion of either the first section or the third section connected to the second section is larger than that of the second section. The first section is used to independently drive the first movable member to move. The second section is accommodated in the preset channel. Wherein, when the connecting shaft and the base are coupled, the preset channel is closed, and the first section and the third section constrain the second section to the preset channel; When the connecting shaft and the base are disassembled, the preset channel is not closed, and the control wire is allowed to separate from the preset channel.

2. The prosthetic system according to claim 1, wherein: The connecting shaft has a first contact surface; The base has a second contact surface matching the first contact surface; The first contact surface is provided with a first through groove, and the second contact surface is provided with a second through groove; When the connecting shaft is coupled to the base, the first contact surface cooperates with the second contact surface, and the first through groove and the second through groove together form the closed preset channel; After the connecting shaft and the base are disassembled, the first contact surface and the second contact surface are separated from each other, so that the preset channel is non-closed.

3. The prosthetic system according to claim 2, wherein: The first contact surface includes a first distal blocking surface at the distal end, a first inclined surface from proximal to distal, and a first proximal blocking surface at the proximal end; The second contact surface includes a second distal blocking surface at the distal end, a second inclined surface from proximal to distal, and a second proximal blocking surface at the proximal end; The first through-slot is provided on the first inclined surface, and the second through-slot is provided on the second inclined surface; The first through slot includes a first slot wall and a first slot opening, and the second through slot includes a second slot wall and a second slot opening; When the connecting shaft is coupled to the base, the first distal blocking surface and the second distal blocking surface are in contact with each other, the first inclined surface and the second inclined surface are in contact with each other, the first proximal blocking surface and the second proximal blocking surface are in contact with each other, the first notch and the second notch are in contact with each other, and the first groove wall and the second groove wall constitute the side wall of the preset channel in a closed state; When the connecting shaft is disassembled from the base, the first groove wall and the second groove wall forming the side wall of the preset channel in a closed state are separated, and the preset channel is non-closed.

4. The prosthetic system according to claim 1, wherein: The connecting shaft has a first contact surface; The base has a second contact surface matching the first contact surface; The first contact surface or the second contact surface is provided with a third through groove; When the connecting shaft is coupled to the base, the first contact surface cooperates with the second contact surface, and the groove wall of the third through groove and the portion opposite to the other contact surface jointly form the closed preset channel; After the connecting shaft and the base are disassembled, the first contact surface and the second contact surface are separated from each other, so that the preset channel is non-closed.

5. The prosthetic system according to claim 4, wherein: The first contact surface includes a third distal blocking surface at the distal end, a third inclined surface extending from proximal to distal, and a third proximal blocking surface at the proximal end; The second contact surface includes a fourth distal blocking surface at the distal end, a fourth inclined surface extending from proximal to distal, a fourth proximal blocking surface at the proximal end, and a transition surface between the fourth inclined surface and the fourth proximal blocking surface; The third through groove is arranged on the third inclined surface and corresponds to the transition surface, and the third through groove further includes a third groove wall and a third notch; When the connecting shaft is coupled to the base, the third distal blocking surface and the fourth distal blocking surface are in contact with each other, the third inclined surface and the fourth inclined surface are in contact with each other, the third proximal blocking surface and the fourth proximal blocking surface are in contact with each other, the third notch and the transition surface are in contact with each other, and the third groove wall and the transition surface constitute the side wall of the preset channel in a closed state; When the connecting shaft is disassembled from the base, the third groove wall constituting the side wall of the preset channel in a closed state is separated from the transition surface, and the preset channel is non-closed.

6. The prosthetic system according to claim 4, wherein: The first contact surface includes a third distal blocking surface at the distal end, a third inclined surface extending from proximal to distal, a third proximal blocking surface at the proximal end, and a transition surface between the third inclined surface and the third proximal blocking surface; The second contact surface includes a fourth distal blocking surface at the distal end, a fourth inclined surface extending from proximal to distal, and a fourth proximal blocking surface at the proximal end; The third through groove is arranged on the fourth inclined surface and corresponds to the transition surface, and the third through groove further includes a third groove wall and a third notch; When the connecting shaft is coupled to the base, the third distal blocking surface and the fourth distal blocking surface are in contact with each other, the third inclined surface and the fourth inclined surface are in contact with each other, the third proximal blocking surface and the fourth proximal blocking surface are in contact with each other, the third notch and the transition surface are in contact with each other, and the third groove wall and the transition surface constitute the side wall of the preset channel in a closed state; When the connecting shaft is disassembled from the base, the third groove wall constituting the side wall of the preset channel in a closed state is separated from the transition surface, and the preset channel is non-closed.

7. The prosthetic system according to claim 2 or 4, characterized in that The connecting shaft includes a first coupling portion, and the base includes a second coupling portion, wherein the first coupling portion or the second coupling portion is axially offset, the first contact surface is located on a side of the first coupling portion facing the second coupling portion, and the second contact surface is located on a side of the second coupling portion facing the first coupling portion; When the first coupling portion or the second coupling portion is driven to be arranged in the axial direction, the first coupling portion and the second coupling portion are coupled, and the first contact surface and the second contact surface cooperate to form the closed preset channel.

8. The prosthetic system according to claim 7, wherein: One of the first coupling portion and the second coupling portion includes a protrusion, and the other includes a groove; When the first coupling portion or the second coupling portion is arranged in an axially offset manner, the protrusion is separated from the groove, so that the connecting shaft and the base are disassembled; When the first coupling portion or the second coupling portion is driven to be arranged in the axial direction, the protrusion is accommodated in the groove, so that the connecting shaft and the base are coupled.

9. The prosthetic system according to any one of claims 1 to 6, characterized in that: The prosthesis further includes a second movable member; The third section is used to independently drive the second movable member to move.

10. The prosthetic system according to claim 9, wherein: The prosthesis is a mitral valve clip or a tricuspid valve clip.

11. The prosthetic system according to claim 10, wherein: The first movable member is a first clamping arm, the second movable member is a second clamping arm, the first clamping arm and the second clamping arm rotate about the axis of the base, and, The first section is movably connected to the first clamping arm, and the second section is movably connected to the second clamping arm.

12. A delivery device for delivering a prosthesis, wherein the prosthesis comprises a base and a first movable member, wherein: The conveying device includes a connecting shaft and a control wire; The connecting shaft is detachably coupled to the base; a preset channel, the preset channel being arranged between the connecting shaft and the base at an angle to the axis of the connecting shaft; The control wire comprises a first section, a second section, and a third section connected in sequence. The size of at least the portion of either the first section or the third section connected to the second section is larger than that of the second section. The first section is used to independently drive the first movable member to move. The second section is accommodated in the preset channel. Wherein, when the connecting shaft and the base are coupled, the preset channel is closed, and the first section and the third section constrain the second section to the preset channel; When the connecting shaft and the base are disassembled, the preset channel is not closed, and the control wire is allowed to separate from the preset channel.

13. A prosthetic system, characterized in that: including a delivery device and a prosthesis; The conveying device includes a connecting shaft and a control wire; The prosthesis includes a base and a first movable member, wherein the base is detachably coupled to the connecting shaft; a preset channel, the preset channel being arranged on the connecting shaft and / or the base at an angle to the axis of the connecting shaft; The control wire comprises a first section, a second section, and a third section connected in sequence. The size of at least the portion of either the first section or the third section connected to the second section is larger than that of the second section. The first section is used to independently drive the first movable member to move. The second section is accommodated in the preset channel. The preset channel has a first state and a second state. When the preset channel is in the first state, a portion of the preset channel for accommodating the second segment has a first size. The first size is smaller than a size of a portion of either the first segment or the third segment connected to the second segment, and is greater than or equal to a size of the second segment. The first segment and the third segment constrain the second segment to the preset channel. When the preset channel is in the second state, the portion of the preset channel for accommodating the second segment has a second size; the second size is larger than the size of the first segment and / or the third segment, and the control wire is allowed to separate from the preset channel.

14. A delivery device for delivering a prosthesis, wherein the prosthesis comprises a base and a first movable member, wherein: The conveying device includes a connecting shaft and a control wire; The connecting shaft is detachably coupled to the base; a preset channel, wherein the preset channel is arranged on the connecting shaft at an angle to the axis of the connecting shaft, or the preset channel is arranged between the connecting shaft and the base at an angle to the axis of the connecting shaft; The control wire comprises a first section, a second section, and a third section connected in sequence. The size of at least the portion of either the first section or the third section connected to the second section is larger than that of the second section. The first section is used to independently drive the first movable member to move. The second section is accommodated in the preset channel. The preset channel has a first state and a second state. When the preset channel is in the first state, a portion of the preset channel for accommodating the second segment has a first size. The first size is smaller than a size of a portion of either the first segment or the third segment connected to the second segment, and is greater than or equal to a size of the second segment. The first segment and the third segment constrain the second segment to the preset channel. When the preset channel is in the second state, the portion of the preset channel for accommodating the second segment has a second size; the second size is larger than the size of the first segment and / or the third segment, and the control wire is allowed to separate from the preset channel.

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