A tissue adhesive patch and a preparation method thereof

By setting up a reinforcement layer in the tissue adhesive patch and introducing specific components into the adhesive layer to form an interpenetrating network structure, the problems of insufficient adhesion and poor mechanical properties of existing tissue adhesives on wet surfaces are solved, and stronger adhesion and mechanical properties are achieved, and antibacterial properties are achieved.

CN119236151BActive Publication Date: 2025-03-21SICHUAN GUONA TECHNOLOGY CO LTD
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Patent Information

Application Number
CN202411764148.2
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-12-04
Publication Date
2025-03-21
Estimated Expiration
2044-12-04

AI Technical Summary

Technical Problem

The existing tissue adhesives have insufficient adhesion on wet surfaces and their mechanical properties cannot meet the needs of use.

Method used

By providing a reinforcing layer in the tissue adhesive patch, a degradable polyester material is used as the reinforcing layer raw material, and catechol-containing substances, acrylates or N-isopropyl acrylamide and quaternary ammonium cationic monomers are introduced into the adhesive layer to form an interpenetrating network structure to enhance the cohesiveness and wet adhesion of the adhesive.

Benefits of technology

It significantly improves the bonding strength and mechanical properties of the tissue adhesive patch, enhances its bonding effect on the wet tissue surface and dry tissue surface, and has certain antibacterial properties.

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Abstract

The invention discloses a tissue adhesive patch and a preparation method thereof, relates to the technical field of medical materials, and solves the technical problems of insufficient adhesive force and poor mechanical properties of existing tissue adhesives. The invention comprises an adhesive layer and a reinforcing layer; the adhesive layer is coated on the surface of the reinforcing layer and light-cured to form the tissue adhesive patch; the raw material of the reinforcing layer is a degradable polyester material; the raw material of the adhesive layer comprises component A, component B, component C and component D; the component A is a degradable polymer material; the component B is acrylate or N-isopropylacrylamide; the component C is a substance containing catechol, and the component D is a quaternary ammonium salt cationic monomer containing an unsaturated double bond; the invention plays a role of enhancing and toughening the adhesive patch through the provision of the reinforcing layer, and simultaneously improves the bonding strength of the adhesive patch.
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