A composite detection method and device for platelet-rich plasma concentration

Abstract

The present invention discloses a composite detection method for platelet-rich plasma concentration, comprising: obtaining a platelet concentration measurement value sequence of platelet-rich plasma; measuring the transmittance of the platelet-rich plasma to obtain a transmittance measurement value sequence; preprocessing the platelet concentration measurement value sequence and the transmittance measurement value sequence to obtain a preprocessing sequence set; and performing composite detection processing on the preprocessing sequence set to obtain blood concentration detection result information. The present invention realizes rapid and accurate detection of platelet concentration during the platelet-rich plasma collection process.

Description

Technical Field

[0001] The present invention relates to the field of blood testing, and in particular to a method and device for composite detection of platelet-rich plasma concentration. Background Art

[0002] In the clinical blood collection process, ensuring that the collected blood meets the quality standards is the key to ensuring the success of blood collection. Currently, the quality of collected blood is often checked by the collector to obtain the platelet concentration of platelet-rich plasma, and then to determine the quality of the final platelet concentration by visually observing whether the plasma is light yellow mist. This method is often affected by the subjective factors of the operator, resulting in the quality test results being not objective and the accuracy rate being low.

[0003] How to achieve rapid and accurate detection of blood quality during the blood collection process is a problem that needs to be solved urgently. Summary of the invention

[0004] The present invention mainly solves the problem of how to realize rapid and accurate detection of platelet concentration during the collection process of platelet-rich plasma. The present invention discloses a composite detection method and device for platelet-rich plasma concentration.

[0005] In a first aspect of the embodiments of the present application, a method for composite detection of platelet-rich plasma concentration is disclosed, comprising:

[0006] S1, obtaining a sequence of platelet concentration measurement values ​​of platelet-rich plasma;

[0007] S2, measuring the transmittance of the platelet-rich plasma to obtain a transmittance measurement value sequence;

[0008] S3, preprocessing the platelet concentration measurement value sequence and the transmittance measurement value sequence to obtain a preprocessed sequence set;

[0009] S4, performing composite detection processing on the pre-processing sequence set to obtain blood concentration detection result information.

[0010] The preprocessing of the platelet concentration measurement value sequence and the transmittance measurement value sequence to obtain a preprocessing sequence set includes:

[0011] S31, performing data cleaning processing on the platelet concentration measurement value sequence and the transmittance measurement value sequence respectively to obtain corresponding cleaned sequences;

[0012] S32, normalizing all cleaned sequences to obtain corresponding normalized sequence values;

[0013] S33, constructing a preprocessing sequence set using all normalized sequence values; the preprocessing sequence set includes a preprocessing platelet concentration measurement value sequence and a preprocessing transmittance measurement value sequence.

[0014] The performing of composite detection processing on the pre-processing sequence set to obtain blood concentration detection result information includes:

[0015] Performing a first discrimination process on the pre-processed transmittance measurement value sequence to obtain a first discrimination result;

[0016] If the first discrimination result is not satisfied, determining the blood concentration test result information as unqualified; if the first discrimination result is satisfied, using the fusion detection model to obtain the blood concentration test result information for the preprocessing sequence set;

[0017] The first discrimination process comprises:

[0018] Calculate the mean a1, median a2, mode a3 and variance a4 of the pre-processed platelet concentration measurement value sequence;

[0019] Determine whether the mean a1, median a2, mode a3, and variance a4 satisfy the inequality group:

[0020] |a1 / a2|≥b1,

[0021] |a3 / a4|≤b2,

[0022] Among them, b1 and b2 are the first discrimination threshold and the second discrimination threshold respectively;

[0023] When the mean a1, the median value a2, the mode value a3 and the variance a4 satisfy the inequality group, the first discrimination result is satisfied; when the mean a1, the median value a2, the mode value a3 and the variance a4 do not satisfy the inequality group, the first discrimination result is not satisfied.

[0024] The method of using the fusion detection model to pre-process the sequence set to obtain blood concentration detection result information includes:

[0025] The preprocessed transmittance measurement value sequence and the preprocessed platelet concentration measurement value sequence are respectively subjected to uniform segmentation processing to obtain a number of corresponding subsequences; the preprocessed transmittance measurement value sequence and the preprocessed platelet concentration measurement value sequence contain the same number of subsequences.

[0026] Using all subsequences of the preprocessed transmittance measurement value sequence, constructing a transmittance matrix;

[0027] Using all subsequences of the preprocessed platelet concentration measurement value sequence, construct a concentration matrix;

[0028] Performing feature sequence extraction processing on the transmittance matrix to obtain a first feature sequence;

[0029] Performing geometric center feature calculation processing on the concentration matrix to obtain a second feature sequence;

[0030] The first feature sequence and the second feature sequence are subjected to inverse weighted fusion processing to obtain blood concentration detection result information.

[0031] The feature sequence extraction process is to extract the smallest number in each column of the matrix to form a first feature sequence z; the expression of the first feature sequence is:

[0032] z=[z1,z2,...,z n ]=[min{z 11 , z 21 , ..., z m1},...,min{z 1n , z 2n , ..., z mn}],

[0033] Among them, z is the first characteristic sequence, z i is the i-th element of the first characteristic sequence, z ij is the element in the i-th row and j-th column of the transmittance matrix, and m and n are the row and column dimensions of the transmittance matrix.

[0034] The expression for the geometric center feature calculation process is:

[0035]

[0036] Among them, p i is the i-th element of the second characteristic sequence, a ij is the element in the i-th row and j-th column of the concentration matrix, and n is the column dimension of the concentration matrix.

[0037] In a second aspect of the embodiment of the present application, a composite concentration detection device for platelet-rich plasma is disclosed, the device comprising:

[0038] A memory storing executable program code;

[0039] a processor coupled to the memory;

[0040] The processor calls the executable program code stored in the memory to execute the concentration composite detection method for platelet-rich plasma.

[0041] In a third aspect of the embodiments of the present application, a computer storable medium is disclosed, wherein the computer storable medium stores computer instructions, and when the computer instructions are called by a computer, they are used to execute the concentration composite detection method for platelet-rich plasma.

[0042] In a fourth aspect of the embodiments of the present application, an information data processing terminal is disclosed, wherein the information data processing terminal is used to implement the composite concentration detection method for platelet-rich plasma.

[0043] The beneficial effects of the present invention are:

[0044] The present invention obtains a platelet concentration measurement value sequence and a transmittance measurement value sequence through measurement, and fuses the two types of sequences. The effective feature extraction of the transmittance data is realized through a fusion detection model. The concentration matrix is ​​subjected to geometric center feature calculation processing to obtain a second feature sequence, thereby realizing the extraction of the center quantity. The blood concentration detection result information is obtained by performing inverse weighted fusion processing on the first feature sequence and the second feature sequence, thereby ensuring the accuracy of the detection result.

[0045] Because the chromaticity is directly dependent on the number or amount of the analyte fixed by the first binding partner fixed to the wall of the carrier, the measurement of this optical property is an indirect measurement of the total number of analytes present in the plasma sample; the present invention indirectly measures the analyte photometry, then uses a predetermined mathematical model to transform the measured chromaticity into a concentration quantification value, and fuses it with the platelet concentration measurement value sequence, while ensuring the accuracy of blood quality assessment, effectively reducing the assessment cost and realizing blood quality assessment at the collection site. BRIEF DESCRIPTION OF THE DRAWINGS

[0046] Figure 1 It is a flow chart for implementing the method of the present invention. DETAILED DESCRIPTION

[0047] In order to better understand the content of the present invention, an embodiment is given here.

[0048] Figure 1 It is a flow chart for implementing the method of the present invention.

[0049] Aiming at the problem of how to realize rapid and accurate detection of platelet concentration in platelet-rich plasma during blood collection, the present invention discloses a composite detection method and device for platelet-rich plasma concentration.

[0050] In a first aspect of the embodiments of the present application, a method for composite detection of platelet-rich plasma concentration is disclosed, comprising:

[0051] S1, obtaining a sequence of platelet concentration measurement values ​​of platelet-rich plasma;

[0052] S2, measuring the transmittance of the platelet-rich plasma to obtain a transmittance measurement value sequence;

[0053] S3, preprocessing the platelet concentration measurement value sequence and the transmittance measurement value sequence to obtain a preprocessed sequence set;

[0054] S4, performing composite detection processing on the pre-processing sequence set to obtain blood concentration detection result information.

[0055] The preprocessing of the platelet concentration measurement value sequence and the transmittance measurement value sequence to obtain a preprocessing sequence set includes:

[0056] S31, performing data cleaning processing on the platelet concentration measurement value sequence and the transmittance measurement value sequence respectively to obtain corresponding cleaned sequences;

[0057] S32, normalizing all cleaned sequences to obtain corresponding normalized sequence values;

[0058] S33, constructing a preprocessing sequence set using all normalized sequence values; the preprocessing sequence set includes a preprocessing platelet concentration measurement value sequence and a preprocessing transmittance measurement value sequence.

[0059] The performing of composite detection processing on the pre-processing sequence set to obtain blood concentration detection result information includes:

[0060] Performing a first discrimination process on the pre-processed transmittance measurement value sequence to obtain a first discrimination result;

[0061] If the first discrimination result is not satisfied, determining the blood concentration test result information as unqualified; if the first discrimination result is satisfied, using the fusion detection model to obtain the blood concentration test result information for the preprocessing sequence set;

[0062] The first discrimination process comprises:

[0063] Calculate the mean a1, median a2, mode a3 and variance a4 of the pre-processed platelet concentration measurement value sequence;

[0064] Determine whether the mean a1, median a2, mode a3, and variance a4 satisfy the inequality group:

[0065] |a1 / a2|≥b1,

[0066] |a3 / a4|≤b2,

[0067] Among them, b1 and b2 are the first discrimination threshold and the second discrimination threshold respectively;

[0068] When the mean a1, the median value a2, the mode value a3 and the variance a4 satisfy the inequality group, the first discrimination result is satisfied; when the mean a1, the median value a2, the mode value a3 and the variance a4 do not satisfy the inequality group, the first discrimination result is not satisfied.

[0069] The method of using the fusion detection model to pre-process the sequence set to obtain blood concentration detection result information includes:

[0070] The preprocessed transmittance measurement value sequence and the preprocessed platelet concentration measurement value sequence are respectively subjected to uniform segmentation processing to obtain a number of corresponding subsequences; the preprocessed transmittance measurement value sequence and the preprocessed platelet concentration measurement value sequence contain the same number of subsequences.

[0071] Using all subsequences of the preprocessed transmittance measurement value sequence, constructing a transmittance matrix;

[0072] Using all subsequences of the preprocessed platelet concentration measurement value sequence, construct a concentration matrix;

[0073] Performing feature sequence extraction processing on the transmittance matrix to obtain a first feature sequence;

[0074] Performing geometric center feature calculation processing on the concentration matrix to obtain a second feature sequence;

[0075] Performing inverse weighted fusion processing on the first feature sequence and the second feature sequence to obtain blood concentration detection result information;

[0076] The feature sequence extraction process is to extract the smallest number in each column of the matrix to form a first feature sequence z; the expression of the first feature sequence is:

[0077] z=[z1,z2,...,z n ]=[min{z 11 , z 21 , ..., z m1},...,min{z 1n , z 2n , ..., z mn}], where z is the first characteristic sequence, z i is the i-th element of the first characteristic sequence, z ij is the element in the i-th row and j-th column of the transmittance matrix, and m and n are the row and column dimensions of the transmittance matrix.

[0078] The expression for the geometric center feature calculation process is:

[0079]

[0080] Among them, p i is the i-th element of the second characteristic sequence, a ij is the element in the i-th row and j-th column of the concentration matrix, and n is the column dimension of the concentration matrix.

[0081] The expression of the inverse weighted fusion process is:

[0082]

[0083] Among them, r is the blood concentration test result information.

[0084] The value of the blood concentration test result information is used to indicate the true concentration of platelets in platelet-rich plasma. The higher the value, the higher the true concentration of platelets in platelet-rich plasma.

[0085] For the measurement of platelet concentration, photoelectric turbidimetry or impedance method can be used; for transmittance measurement, a haze meter can be used.

[0086] In a second aspect of the embodiment of the present application, a composite concentration detection device for platelet-rich plasma is disclosed, the device comprising:

[0087] A memory storing executable program code;

[0088] a processor coupled to the memory;

[0089] The processor calls the executable program code stored in the memory to execute the concentration composite detection method for platelet-rich plasma.

[0090] In a third aspect of the embodiments of the present application, a computer storable medium is disclosed, wherein the computer storable medium stores computer instructions, and when the computer instructions are called by a computer, they are used to execute the concentration composite detection method for platelet-rich plasma.

[0091] In a fourth aspect of the embodiments of the present application, an information data processing terminal is disclosed, wherein the information data processing terminal is used to implement the composite concentration detection method for platelet-rich plasma.

[0092] The above is only an embodiment of the present application and is not intended to limit the present application. For those skilled in the art, the present application may have various changes and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application should be included in the scope of the claims of the present application.

Claims

1. A composite concentration detection method for platelet-rich plasma, characterized in that: include: S1, obtaining a sequence of platelet concentration measurement values ​​of platelet-rich plasma; S2, measuring the transmittance of the platelet-rich plasma to obtain a transmittance measurement value sequence; S3, preprocessing the platelet concentration measurement value sequence and the transmittance measurement value sequence to obtain a preprocessed sequence set; S4, performing composite detection processing on the pre-processing sequence set to obtain blood concentration detection result information; The preprocessing of the platelet concentration measurement value sequence and the transmittance measurement value sequence to obtain a preprocessing sequence set includes: S31, performing data cleaning processing on the platelet concentration measurement value sequence and the transmittance measurement value sequence respectively to obtain corresponding cleaned sequences; S32, normalizing all cleaned sequences to obtain corresponding normalized sequence values; S33, constructing a preprocessing sequence set using all normalized sequence values; the preprocessing sequence set includes a preprocessing platelet concentration measurement value sequence and a preprocessing transmittance measurement value sequence; The performing of composite detection processing on the pre-processing sequence set to obtain blood concentration detection result information includes: Performing a first discrimination process on the pre-processed transmittance measurement value sequence to obtain a first discrimination result; If the first discrimination result is not satisfied, determining the blood concentration test result information as unqualified; if the first discrimination result is satisfied, using the fusion detection model to obtain the blood concentration test result information for the preprocessing sequence set; The first discrimination process comprises: Calculate the mean a1, median a2, mode a3 and variance a4 of the pre-processed platelet concentration measurement value sequence; Determine whether the mean a1, median a2, mode a3, and variance a4 satisfy the inequality group: |a1 / a2|≥b1, |a3 / a4|≤b2, Among them, b1 and b2 are the first discrimination threshold and the second discrimination threshold respectively; When the mean a1, median a2, mode a3 and variance a4 satisfy the inequality group, the first discrimination result is satisfied; when the mean a1, median a2, mode a3 and variance a4 do not satisfy the inequality group, the first discrimination result is not satisfied; The method of using the fusion detection model to pre-process the sequence set to obtain blood concentration detection result information includes: The pre-processed transmittance measurement value sequence and the pre-processed platelet concentration measurement value sequence are respectively subjected to uniform segmentation processing to obtain a plurality of corresponding sub-sequences; the pre-processed transmittance measurement value sequence and the pre-processed platelet concentration measurement value sequence contain the same number of sub-sequences; Using all subsequences of the preprocessed transmittance measurement value sequence, constructing a transmittance matrix; Using all subsequences of the preprocessed platelet concentration measurement value sequence, construct a concentration matrix; Performing feature sequence extraction processing on the transmittance matrix to obtain a first feature sequence; Performing geometric center feature calculation processing on the concentration matrix to obtain a second feature sequence; Performing inverse weighted fusion processing on the first feature sequence and the second feature sequence to obtain blood concentration detection result information; The feature sequence extraction process is to extract the smallest number in each column of the matrix to form a first feature sequence z; the expression of the first feature sequence is: z=[z1,z2,...,z n ]=[min{z 11 , z 21 , ..., z m1 },...,min{z 1n , z 2n , ..., z mn }], where z is the first characteristic sequence, z i is the i-th element of the first characteristic sequence, z ij is the element of the i-th row and j-th column of the transmittance matrix, and m and n are the row dimension and column dimension of the transmittance matrix; The expression for the geometric center feature calculation process is: Among them, p i is the i-th element of the second characteristic sequence, a ij is the element in the i-th row and j-th column of the concentration matrix, and n is the column dimension of the concentration matrix.

2. A composite detection device for platelet-rich plasma concentration, characterized in that: The device comprises: A memory storing executable program code; a processor coupled to the memory; The processor calls the executable program code stored in the memory to execute the concentration composite detection method for platelet-rich plasma as described in claim 1.

3. A computer storable medium, characterized in that: The computer storable medium stores computer instructions, and when the computer instructions are called by a computer, they are used to execute the concentration composite detection method for platelet-rich plasma as claimed in claim 1.

4. An information data processing terminal, characterized in that: The information data processing terminal is used to implement the composite concentration detection method for platelet-rich plasma as described in claim 1.

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