Topical compositions and embodiments thereof

Abstract

The present invention provides a topical composition comprising (a) from 70% to 95% (w / w) of a triglyceride; (b) 1% to 15% (w / w) of an ester of a C8 to C16 fatty acid; and (c) 0.1% to 0.3% (w / w) of vitamin E, wherein the triglyceride is a medium chain triglyceride comprising C6 to C12 fatty acids. The present invention provides a method for preparing a topical composition. The invention also provides a topical skin care composition and a topical hair care composition.

Description

Technical Field

[0001] The present invention relates broadly to the field of cosmetics. In particular, the present invention relates to a topical composition for skin care and hair care. The present invention also relates to a method for preparing the topical composition. Background Art

[0002] The global cosmetics industry is moving towards safe, natural, sustainable and eco-friendly cosmetics. In the cosmetics industry, especially in skin care and hair care, synthetic ingredients are not preferred. The beauty industry is always looking for alternatives to synthetic ingredients such as parabens, phthalates, sodium lauryl sulfate and silicones because they are concerned about the perceived health risks.

[0003] Silicones are a class of polymers ranging from low viscosity fluids to viscous gums to cross-linked elastomers and hard resins. Silicones are derived from silica through an energy-intensive process and are further subjected to extensive chemical processing before being added to cosmetics. Dimethicone, cyclomethicone, cyclohexasiloxane, cetearyl methicone, cyclopentasiloxane are some of the silicone ingredients commonly used in cosmetics. Despite the versatility of silicones in providing conditioning effects on skin and hair, silicones are not the first choice of consumers because they are occlusive ingredients. The protective layer they form on the skin provides a pleasant sensory experience for a short time, however, the occlusive nature may worsen congested skin types by trapping dirt and clogging pores. In the long run, silicones may not contribute to overall health and improvement of the skin. There are other disadvantages to using silicones in hair care products. The most common one is that silicones prevent hair follicles from getting oxygen, which leads to hair loss. Certain silicone derivatives, such as cyclomethicone, cause environmental damage and are strictly restricted for use in personal care products.

[0004] There is a pressing need in the art for topical compositions that are silicone-free, non-toxic and biocompatible, moisturize and provide nutrition to the skin and hair, and are readily biodegradable. Summary of the invention

[0005] In one aspect of the present invention, a topical composition is provided, comprising (a) 70% to 95% (w / w) triglycerides; (b) 1% to 15% (w / w) C8 to C 16 and (c) 0.1% to 0.3% (w / w) vitamin E, wherein the triglyceride is a fatty acid ester comprising C6 to C 12 Medium chain triglycerides of fatty acids.

[0006] In another aspect of the present invention, a method for preparing a topical composition is provided, the topical composition comprising (a) 70% to 95% (w / w) triglycerides; (b) 1% to 15% (w / w) C8 to C 16 and (c) 0.1% to 0.3% (w / w) vitamin E, wherein the triglyceride is a fatty acid ester comprising C6 to C 12 The method comprises stirring a stoichiometric ratio of triglycerides, C8 to C16 fatty acids at a temperature ranging from 20°C to 60°C and a stirring speed ranging from 50 rpm to 1200 rpm. 16 Fatty acid esters and vitamin E are in contact, wherein the triglyceride is a 12 Medium chain triglycerides of fatty acids.

[0007] In another aspect of the present invention, a cosmetic preparation is provided, comprising a topical composition and an additive, wherein the topical composition comprises (a) 70% to 95% (w / w) triglycerides; (b) 1% to 15% (w / w) C8 to C 16 and (c) 0.1% to 0.3% (w / w) vitamin E, wherein the triglyceride is a fatty acid ester comprising C6 to C 12 Medium chain triglycerides of fatty acids.

[0008] In another aspect of the present invention, there is provided a method of treating keratinous tissue of a subject, the method comprising topically applying to the keratinous tissue a composition or cosmetic formulation described herein.

[0009] In another aspect of the present invention, there is provided a method of treating hair, the method comprising topically applying a composition or cosmetic formulation as described herein to hair in need of treatment, wherein the composition or formulation is topically applied to the hair to treat the hair.

[0010] In another aspect of the present invention, a method of moisturizing the skin is provided, the method comprising applying to the skin an effective amount of the composition or cosmetic formulation described herein.

[0011] In other aspects of the present invention, a cosmetic kit is provided, comprising a) a first compartment comprising a composition or cosmetic formulation described herein; and b) a second compartment comprising an auxiliary tool.

[0012] In another aspect of the present invention, a skin care topical composition is provided, comprising: (a) 70% to 95% (w / w) triglycerides; (b) 1% to 15% (w / w) isopropyl myristate; and (c) 0.1% to 0.3% (w / w) vitamin E, wherein the triglycerides are C6 to C 12 Medium chain triglycerides of fatty acids.

[0013] In another aspect of the present invention, a hair care topical composition is provided, comprising: (a) 70% to 95% (w / w) triglycerides; (b) 1% to 15% (w / w) caprylate caprate; and (c) 0.1% to 0.3% (w / w) vitamin E, wherein the triglycerides are C6 to C 12 Medium chain triglycerides of fatty acids.

[0014] These and other features, aspects and advantages of the present subject matter will be better understood with reference to the following description and the appended claims. This summary is provided to introduce some concepts in a simplified form. This summary is not intended to identify key features or essential features of the claimed subject matter, nor is it intended to be used to limit the scope of the claimed subject matter. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] The following drawings constitute a part of this specification and are included to further illustrate aspects of the present invention. The present invention may be better understood by referring to the drawings in conjunction with the detailed description of specific embodiments illustrated herein.

[0016] 1 shows A) the cumulative scores of volunteers for Sample 1 (A_89.8) and B) the overall cumulative scores of Sample 1 (A_89.8) for sensory parameters relative to silicones (cyclopentasiloxane, dimethicone) according to an embodiment of the present invention.

[0017] 2 shows a moisturizing analysis of A) Sample 1 (A_89.8) compared to silicones (B) cyclopentasiloxane and C) dimethicone) according to an embodiment of the present invention.

[0018] 3 shows the formation of inhibition zones in an agar diffusion assay of mouse fibroblast line (3T3) cells, A) sample 1 (A_89.8) versus B) a negative control sample and C) a positive control sample, according to an embodiment of the present invention.

[0019] 4 shows the dose-dependent activity induced by A) a reference standard and B) sample 1 (A_89.8) in mouse fibroblast line (3T3) cells, according to an embodiment of the present invention.

[0020] 5 shows A) the cumulative score of Sample 2 (B_89.8) and B) the overall cumulative score of Sample 2 (B_89.8) for all sensory parameters relative to silicones (cyclopentasiloxane, dimethicone), according to an embodiment of the present invention.

[0021] 6 shows a moisturizing analysis of A) Sample 2 (B_89.8) compared to silicone (B) cyclopentasiloxane and C) dimethicone) according to an embodiment of the present invention.

[0022] 7 shows the formation of inhibition zones in an agar diffusion assay of mouse fibroblast line (3T3) cells, A) sample 2 (B_89.8) versus B) a negative control sample and C) a positive control sample, according to an embodiment of the present invention.

[0023] 8 shows the dose-dependent activity induced by A) Sample 2 (B_89.8) and B) a reference standard in mouse fibroblast line (3T3) cells, according to an embodiment of the present invention.

[0024] Fig. 9 Shown is the overall cumulative rating of sensory parameters for Sample 3 (A_74.8) relative to commercial silicones (cyclopentasiloxane, dimethicone) according to an embodiment of the present invention.

[0025] Fig.10 Shown is the overall cumulative score for sensory parameters of Sample 4 (B_74.8) relative to silicones (cyclopentasiloxane, dimethicone), according to an embodiment of the present invention.

[0026] Fig.11 Shown are moisturizing analyses of sample 3 (A_74.8) and sample 4 (B_74.8) according to an embodiment of the present invention.

[0027] Fig.12 Shown is the overall cumulative score for sensory parameters of Sample 5 (A_59.8) relative to silicones (cyclopentasiloxane, dimethicone) according to an embodiment of the present invention.

[0028] Fig.13 Shown is the overall cumulative score for sensory parameters of Sample 6 (B_59.8) relative to silicones (cyclopentasiloxane, dimethicone), according to an embodiment of the present invention.

[0029] Fig.14 Shown are moisturizing analyses of sample 5 (A_59.8) and sample 6 (B_59.8) according to an embodiment of the present invention. DETAILED DESCRIPTION

[0030] Those skilled in the art will appreciate that the present invention may be subjected to variations and modifications other than those specifically described. It should be understood that the present invention includes all such variations and modifications. The present invention also includes all such steps, features, compositions and compounds mentioned or illustrated individually or collectively in this specification, and any and all combinations of any or a plurality of these steps or features.

[0031] definition

[0032] For convenience, certain terms and examples used in the specification are described here before further describing the present invention. These definitions should be read in light of the remainder of the present invention and can be understood by those skilled in the art. The terms used herein have meanings that are recognized and known to those skilled in the art, however, for convenience and completeness, specific terms and their meanings are set forth below.

[0033] The articles "a," "an," and "the" are used to refer to one or to more than one (ie, to at least one) of the grammatical object of the article.

[0034] The terms "comprising" and "including" are used in an inclusive, open sense, meaning that additional elements may be included. They are not intended to be interpreted as "consisting only of. . . . "

[0035] In this specification, unless the context requires otherwise, the term "comprise" and variations thereof (such as "include" and "comprising") will be understood to imply the inclusion of stated elements or steps or combinations of elements or steps but not the exclusion of any other elements or steps or combinations of elements or steps.

[0036] The term "including" is used to mean "including, but not limited to." "Including" and "including, but not limited to" are used interchangeably.

[0037] As used herein, the term "topical" refers to the use of a composition or formulation described herein, whether alone or incorporated in a suitable form and applied externally to a site of keratinous tissue, hair or skin, to exert a local effect.

[0038] The term "sensory analysis" refers to a method of analyzing and interpreting the characteristics of a preparation as perceived by the five senses (eg, sight, hearing, touch, taste, and smell).

[0039] The term "moisture retention analysis" refers to a method of measuring moisture content before and after application of a composition.

[0040] The term "fatty acid" refers to a carboxylic acid with a long saturated or unsaturated aliphatic chain. The number of carbon atoms in a fatty acid can vary from 4 to 28. In particular, in the present invention, a fatty acid with a C6 to C 16The term "fatty acid" of the present invention includes, but is not limited to, myristic acid, capric acid, caprylic acid, caproic acid, lauric acid, or a combination thereof. The term "ester of fatty acid" refers to a C8 to C 16 Esters of fatty acids, in particular esters of myristic acid, esters of caprylic / capric acid. The term "esters of fatty acids" includes isopropyl myristate and caprylate caprate. The terms caprylate caprate and cococaprylate caprate are used interchangeably and refer to esters of the natural fatty alcohols of caprylic and capric acid. The term "medium chain fatty acids" refers to fatty acids having 6 to 12 carbon atoms.

[0041] The term "medium chain triglyceride" (MCT) means a triglyceride of fatty acids with a medium carbon chain. In other words, a medium chain triglyceride is a glyceride of two or three fatty acids with a carbon chain of 6 to 12, which are aliphatic and saturated. The MCT of the present invention has an acid value of less than 0.1 and a color index of less than 50.

[0042] The term "acid value" refers to the number of milligrams of base (potassium hydroxide) required to neutralize one gram of fatty acids in a sample. In the present invention, the acid value refers to the number of milligrams of base required to neutralize one gram of free fatty acids present in MCT. A lower acid value indicates that the MCT is almost completely esterified and minimal free fatty acids are present. This further indicates the compatibility of MCT for use in topical compositions or cosmetic formulations.

[0043] The term "color index" means a color scale or yellowness index, which is used to evaluate the quality of liquids with a color that is transparent to light yellow. The color scale ranges from 0 for distilled water to 500 for a yellow solution (one millionth of platinum cobalt to water). A color index of zero is transparent white or water white, and 500 is light yellow. In the present invention, the color index of MCT is less than 50, which means that MCT has no color at all.

[0044] The term "vitamin E" refers to a fat-soluble vitamin that has several forms, including four tocopherols and four tocotrienols. Vitamin E is a strong antioxidant that neutralizes harmful free radicals and protects the skin from damage by ultraviolet radiation.

[0045] The term "keratinous tissue" used herein means tissue having keratin, which is a structural fibrous protein also known as hard protein. In the present invention, the term "keratinous tissue" means hair and skin.

[0046] The term "RH" means relative humidity, which is a percentage that represents the ratio of the amount of water vapor in the air at a given temperature to the maximum amount of water vapor at the same temperature. In other words, relative humidity also represents the ratio of the partial pressure of water vapor to the equilibrium vapor pressure of water at the same temperature. In the present invention, the chemical stability of the composition is evaluated at 45°C under 70% RH conditions.

[0047] The term "mouse fibroblast cell line (3T3)" refers to mouse-derived fibroblasts (which are the most common cells in animal connective tissue). In the present invention, the mouse fibroblast cell line (3T3) is used as a skin model to study the cell compatibility and skin reactivity of the composition, because the skin is mainly composed of connective tissue.

[0048] Ratio, concentration, amount and other numerical data can be presented in range format herein.It should be understood that this range format is used only for convenience and brevity, and should be flexibly interpreted as not only including the numerical value clearly listed as the limit of the range, but also including all individual numerical values ​​or sub-ranges contained in the range, as each numerical value and sub-range are clearly listed.For example, the temperature range of 20 ℃ to 60 ℃ should be interpreted as not only including the clearly listed limits of -20 ℃ to 60 ℃, but also including sub-ranges (such as 25 ℃ to 35 ℃, 45 ℃ to 55 ℃, etc.) and the single amount (including fractional amount) in the range (such as, for example, 40 ℃, 50 ℃, 53.5 ℃ and 55 ℃).

[0049] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which the invention belongs. Although any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, preferred methods and materials are now described.

[0050] The present invention is not to be limited in scope by the specific embodiments described herein, which are intended for purposes of illustration only. Functionally equivalent products, compositions, and methods are clearly within the scope of the invention described herein.

[0051] As mentioned above, conventional cosmetics and personal care products have various limitations. Available cosmetics include synthetic products, especially silicones, which form a protective but occlusive film that prevents the skin from naturally perspiring and breathing, thereby clogging the pores and further worsening congested skin types. In addition, silicones as part of hair care products prevent the hair follicles from getting oxygen, thereby causing hair loss. Moreover, silicone-containing products remain problematic in terms of safety and toxicity. Most of the cosmetics containing silicones have been found to be non-biodegradable and generally harmful to the environment. Currently, there is a green movement going on in the world, and people prefer to use natural ingredients of plant origin in all products related to health and human welfare. Therefore, silicone-free cosmetics and personal care products are becoming more popular than conventional products.

[0052] The present invention thus solves the problems existing in the art by providing a composition, based on a combination of ingredients of natural origin, that forms a film on the skin and contributes to improved moisturizing and nourishing capacity, and overall, that enhances sensory sensations. The composition of the present invention is a silicone-free composition that avoids the problems existing in conventional cosmetic compositions containing silicone.

[0053] Therefore, the present invention provides a topical composition comprising triglycerides, C8 to C 16 Esters of fatty acids and vitamin E. Medium chain triglycerides (MCT) are obtained as esterification products of glycerol and medium chain fatty acids. These MCTs are suitable for addition as a component in cosmetic compositions that provide a soothing and non-greasy emollient with neutral sensory properties. MCTs also provide a long shelf life and can therefore also be used as a carrier oil, and they do not interfere with the scent of aromatic blends, are quickly absorbed, do not stain clothing, and leave a silky and non-greasy feel to the skin. C8 to C 16The esters of fatty acids are isopropyl myristate and caprylate caprate. Isopropyl myristate, which is an ester of isopropyl alcohol and myristic acid, is a polar emollient used in compositions where skin absorption is desired and is a skin enhancer. Caprylate caprate or coco caprylate caprate is an ester of natural fatty alcohols, caprylic acid and capric acid, and is 100% derived from natural renewable raw materials. It has a unique chemical composition and chain length distribution, making it lighter than conventional grades of coco caprylate caprate. Caprylate caprate provides an enhanced sensory effect and is highly stable. Caprylate caprate is also able to spread quickly and provides low greasiness. Therefore, due to the above advantages and being derived from MCTs from natural sources, isopropyl myristate / caprylate caprate is a suitable alternative to silicones in cosmetics. Vitamin E is an antioxidant and additionally provides better absorption by the skin, thereby providing nutrition to the skin and hair. Other antioxidants (e.g., butylated hydroxyanisole, butylated hydroxytoluene) do not exhibit this absorption property and are therefore not preferred ingredients for topical compositions. Thus, the topical composition of the present invention comprises medium chain triglycerides, isopropyl myristate or coco-caprylate caprate and vitamin E, and the composition is an effective and synergistic composition for enhancing skin retention, nourishing the emollient layer, increasing moisture levels and enhancing sensory sensations. The ingredients of the composition have moisturizing and nourishing capabilities, are generally safe, non-comedogenic, non-toxic, silicone-free and biodegradable, and provide a hydrating or moisturizing effect.

[0054] In an embodiment of the present invention, a topical composition is provided, comprising (a) 70% to 95% (w / w) triglycerides; (b) 1% to 15% (w / w) C8 to C 16 and (c) 0.1% to 0.3% (w / w) vitamin E, wherein the triglyceride is a fatty acid ester comprising C6 to C 12 Medium chain triglycerides of fatty acids.

[0055] In an embodiment of the present invention, a topical composition is provided, comprising (a) 75% to 92% (w / w) triglycerides; (b) 5% to 12% (w / w) C8 to C 16 and (c) 0.15% to 0.25% (w / w) vitamin E, wherein the triglyceride is a fatty acid ester comprising C6 to C 12 In another embodiment of the present invention, a topical composition is provided, comprising (a) 89% to 90% (w / w) triglycerides; (b) 9% to 11% (w / w) C8 to C 16 and (c) 0.18% to 0.22% (w / w) vitamin E, wherein the triglyceride is a fatty acid ester comprising C6 to C 12In another embodiment of the present invention, a topical composition is provided, comprising (a) 89.8% (w / w) triglycerides; (b) 10% (w / w) C8 to C 16 and (c) 0.2% (w / w) vitamin E, wherein the triglyceride is a fatty acid ester comprising C6 to C 12 Medium chain triglycerides of fatty acids.

[0056] In an embodiment of the present invention, there is provided a topical composition as described herein, wherein C8 to C 16 The esters of fatty acids are isopropyl myristate or caprylate caprate.

[0057] In an embodiment of the present invention, there is provided a topical composition as described herein, wherein the triglyceride has an acid value of less than 0.1 and a color index of less than 50.

[0058] In an embodiment of the present invention, a topical composition is provided, the topical composition comprising (a) 70% to 95% (w / w) of a compound comprising C6 to C 12 (b) 1% to 15% (w / w) of isopropyl myristate or caprylate caprate; and (c) 0.1% to 0.3% (w / w) of vitamin E, wherein the triglyceride is a medium chain triglyceride containing C6 to C 12 Fatty acids and medium chain triglycerides having an acid value of less than 0.1 and a color index of less than 50.

[0059] In an embodiment of the present invention, there is provided a topical composition as described herein, wherein the composition is for use in skin care or hair care.

[0060] In an embodiment of the present invention, there is provided a topical composition as described herein, wherein the composition is chemically stable at 45°C, 70% RH for at least 3 months.

[0061] In an embodiment of the present invention, there is provided a topical composition as described herein, wherein the composition is stable and exhibits cytocompatibility.

[0062] In an embodiment of the present invention, a topical composition for skin care or hair care is provided, the composition comprising (a) 70% to 95% (w / w) triglycerides; (b) 1% to 15% (w / w) C8 to C 16 and (c) 0.1% to 0.3% (w / w) vitamin E, wherein the triglyceride is a fatty acid ester comprising C6 to C 12The invention relates to a medium chain triglyceride of fatty acids, and the composition is chemically stable at 45° C. and 70% RH for at least 3 months and exhibits cell compatibility.

[0063] In an embodiment of the present invention, there is provided a topical composition as described herein, wherein the composition further comprises an ingredient selected from the group consisting of an antimicrobial agent, an antibacterial agent, an antifungal agent, an antiprotozoal agent, and an antiviral agent.

[0064] In an embodiment of the present invention, a topical composition for skin care or hair care is provided, the composition comprising (a) 70% to 95% (w / w) triglycerides; (b) 1% to 15% (w / w) C8 to C 16 (c) 0.1% to 0.3% (w / w) vitamin E; and (d) an ingredient selected from antimicrobial agents, antibacterial agents, antifungal agents, antiprotozoal agents and antiviral agents, wherein the triglyceride is a C6 to C 12 Medium chain triglycerides of fatty acids.

[0065] In an embodiment of the present invention, a method for preparing a topical composition is provided, wherein the topical composition comprises (a) 70% to 95% (w / w) triglycerides; (b) 1% to 15% (w / w) C8 to C 16 and (c) 0.1% to 0.3% (w / w) vitamin E, wherein the triglyceride is a fatty acid ester comprising C6 to C 12 The method comprises stirring a stoichiometric ratio of triglycerides, C8 to C16 fatty acids at a temperature ranging from 20°C to 60°C and a stirring speed ranging from 50 rpm to 1200 rpm. 16 In another embodiment of the present invention, wherein the stoichiometric ratio of triglycerides, C8 to C 16 The contacting of the fatty acid esters and vitamin E is carried out at a temperature ranging from 25°C to 50°C and under stirring at a speed ranging from 100 rpm to 1000 rpm. In another embodiment of the present invention, wherein the stoichiometric ratio of triglycerides, C8 to C 16 The esters of fatty acids and vitamin E are contacted at a temperature of 27°C and stirred at a speed of 150 rpm. In another embodiment of the present invention, the stoichiometric ratio of triglycerides, C8 to C 16 The contacting of the fatty acid ester and vitamin E is carried out for a period of time ranging from 10 minutes to 60 minutes.

[0066] In an embodiment of the present invention, a cosmetic preparation is provided, the cosmetic preparation comprising (a) 70% to 95% (w / w) triglycerides; (b) 1% to 15% (w / w) C8 to C16 (c) 0.1% to 0.3% (w / w) vitamin E; and (d) an additive, wherein the triglyceride is a fatty acid ester comprising C6 to C 12 Medium chain triglycerides of fatty acids.

[0067] In an embodiment of the invention there is provided a cosmetic formulation as described herein, wherein the additive is selected from a preservative, a pH adjuster, a chelating agent or a co-solvent. In another embodiment of the invention the cosmetic formulation is topically applied to the hair or skin.

[0068] In an embodiment of the present invention, a cosmetic preparation is provided, the cosmetic preparation comprising (a) 70% to 95% (w / w) triglycerides; (b) 1% to 15% (w / w) C8 to C 16 (c) 0.1% to 0.3% (w / w) of vitamin E; and (d) an additive selected from a preservative, a pH adjuster, a chelating agent or a co-solvent, wherein the triglyceride is a C6 to C 12 Medium chain triglycerides of fatty acids.

[0069] In an embodiment of the present invention, there is provided a method of treating keratinous tissue of a subject, the method comprising topically applying the composition or cosmetic formulation described herein to the keratinous tissue. In another embodiment of the present invention, the keratinous tissue is skin or hair.

[0070] In an embodiment of the present invention, there is provided a method of treating hair, the method comprising topically applying a composition or cosmetic formulation as described herein to hair in need of treatment, wherein the composition or formulation is topically applied to the hair to treat the hair.

[0071] In an embodiment of the present invention, there is provided a method of moisturizing the skin, the method comprising applying to the skin an effective amount of the composition or cosmetic formulation described herein.

[0072] In an embodiment of the present invention, a cosmetic kit is provided, the cosmetic kit comprising a) a first compartment, the first compartment comprising a topical composition or cosmetic formulation described herein; and b) a second compartment, the second compartment comprising an auxiliary tool. In one embodiment of the present invention, the cosmetic kit also includes a user manual. In another embodiment of the present invention, the cosmetic kit includes a third compartment, the third compartment comprising a cleanser, the cleanser including but not limited to sulfates, sulfonates, glucosides, taurates, betaines, cocamidopropyl betaine, amides, etc.

[0073] In an embodiment of the present invention, a skin care topical composition is provided, the skin care topical composition comprising: (a) 70% to 95% (w / w) triglycerides; (b) 1% to 15% (w / w) isopropyl myristate; and (c) 0.1% to 0.3% (w / w) vitamin E, wherein the triglycerides are C6 to C 12 In another embodiment of the present invention, a skin care topical composition is provided, the skin care topical composition comprising: (a) 75% to 90% (w / w) triglycerides; (b) 5% to 12% (w / w) isopropyl myristate; and (c) 0.15% to 0.3% (w / w) vitamin E, wherein the triglyceride is a medium chain triglyceride containing C6 to C 12 In another embodiment of the present invention, a skin care topical composition is provided, the skin care topical composition comprising: (a) 89.8% (w / w) triglycerides; (b) 10% (w / w) isopropyl myristate; and (c) 0.2% (w / w) vitamin E, wherein the triglyceride is a medium chain triglyceride containing C6 to C 12 Medium chain triglycerides of fatty acids.

[0074] In an embodiment of the present invention, a hair care topical composition is provided, the hair care topical composition comprising: (a) 70% to 95% (w / w) triglycerides; (b) 1% to 15% (w / w) caprylate caprate; and (c) 0.1% to 0.3% (w / w) vitamin E, wherein the triglycerides are C6 to C 12 In another embodiment of the present invention, a hair care topical composition is provided, comprising: (a) 75% to 90% (w / w) triglycerides; (b) 5% to 12% (w / w) caprylate caprate; and (c) 0.15% to 0.3% (w / w) vitamin E, wherein the triglyceride is a medium chain triglyceride containing C6 to C 12 In another embodiment of the present invention, a hair care topical composition is provided, the hair care topical composition comprising: (a) 89.8% (w / w) triglycerides; (b) 10% (w / w) caprylate caprate; and (c) 0.2% (w / w) vitamin E, wherein the triglyceride is a medium chain triglyceride containing C6 to C 12 Medium chain triglycerides of fatty acids.

[0075] In an embodiment of the present invention, there is provided a topical composition or cosmetic formulation as described herein, wherein the composition or formulation is effective in treating skin and hair and providing moisturizing effects.

[0076] In an embodiment of the present invention, there is provided a topical composition or cosmetic formulation as described herein, wherein the composition is in the form of a cream, gel, lotion or ointment.

[0077] Although the subject matter has been described in considerable detail with reference to certain examples and implementations, other implementations are possible.

[0078] Example

[0079] The present invention will now be described using working examples, which are intended to illustrate the work of the present invention and are not intended to restrictively imply any limitation to the scope of the present invention. Unless otherwise defined, all technical terms and scientific terms used herein have the same meaning as those generally understood by those skilled in the art to which the present invention belongs. Although methods and materials similar or equivalent to the methods and materials described herein can be used in the practice of the disclosed methods and compositions, exemplary methods, devices and materials are described herein. It should be understood that the present invention is not limited to the specific methods and experimental conditions described, because these methods and conditions may be applicable.

[0080] Materials and methods

[0081] The medium chain fatty acids, glycerol, isopropyl myristate, caprylate caprate (coco caprylate caprate) and vitamin E used are all commercially available. Medium chain triglycerides are obtained as esterification products of glycerol and medium chain fatty acids. The MCT used in the present invention has an acid value of less than 0.1 and a color index of less than 50. The positive control represents sodium dodecyl sulfate, and the negative control represents phosphate buffered saline.

[0082] For comparative purposes, the commercially available silicone ingredients dimethicone and cyclopentasiloxane were used.

[0083] Example 1

[0084] Preparation of topical compositions

[0085] Different topical compositions were prepared by contacting stoichiometric ratios (Table 1) of medium chain triglycerides, isopropyl myristate or coco-caprylate caprate and vitamin E at temperatures ranging from 20°C to 60°C with stirring at speeds ranging from 50 rpm to 1200 rpm. In the examples, sample 1, denoted A-89.8, was prepared by contacting 89.8% (w / w) MCT with 10% (w / w) isopropyl myristate and 0.2% (w / w) vitamin E at a temperature of 27°C with stirring at a speed of 150 rpm for a period of 10 minutes to 60 minutes.

[0086] Table 1

[0087]

[0088] Sensory analysis

[0089] The samples prepared as mentioned in Table 1 were further evaluated to analyze their sensory effects. To this end, a panel of 9 healthy volunteers aged between 25 and 50 who were trained in sensory evaluation were selected and a series of exhaustive test parameters were performed to determine the sensory efficacy of the samples of the topical composition relative to commercial silicones (cyclopentasiloxane, dimethicone). The volunteers were first asked to analyze the appearance and smell of each sample, and then applied the sample to the forearm in a circular motion until it disappeared. In order to evaluate the acceptability of the topical composition, each volunteer filled out a questionnaire to evaluate sensory parameters such as fragrance, texture, initial skin feel, gloss, absorption, skin feel during application, feeling after application, and impact on the skin. The volunteers were asked to use a scale of 0 to 5 for scoring, wherein 5 is the highest score in the scale. For example, in the skin feel during application, a score of 5 means a more silky feeling, and a score of 0 means a rough feeling.

[0090] Moisturizing analysis

[0091] The topical composition samples of the present invention and commercial silicone (cyclopentasiloxane, dimethicone) were applied to the skin patch and analyzed for moisture content over a duration of 8 hours. Tests were conducted on 3 volunteers. Three areas were marked on the skin of the hand. The composition was applied by rubbing in a circular direction for two minutes on the marked area. The third area remained blank. After drying for five minutes, the readings were read by the Scaler Moisture Checker. The room temperature was maintained at 20°C, and the humidity was maintained at 60%RH. Moisture analysis was performed using a moisture checker from the Scalar Impressive factory. The scalar moisture checker measures the dielectric constant of the skin based on the capacitance principle. Readings between 27 and 29 were shown as normal skin types. The checker was pressed vertically on the desired area of ​​the skin and kept for a few seconds. The checker showed the amount of moisture on the surface at the reference, after application, and 2, 4, 6, 8 hours after application. Moisture levels of 45.1 and above indicate very high moisture levels, when the moisture level is between 39.1 and 45.0, it is normal high, between 27.1 and 39.0 is normal medium, between 22.1 and 27.0 is normal low, between 12.1 and 22.0 is low, and below 12.1 is very low moisture levels. A graph of time and moisture level content after application of each composition was plotted.

[0092] Skin reactivity analysis

[0093] The topical composition samples were analyzed for skin reactivity by agar diffusion test. Mouse fibroblast cell line (3T3) cells were inoculated into 60mm tissue culture grade plastic culture dishes and cultured for 24 hours. After 24 hours, a layer of 1% agar was used to replace the culture medium. A stock solution of a reference standard of 100mg / ml was prepared in sterile phosphate buffered saline (PBS) and tested at 10% (100mg / ml). 5μl of the reference standard was loaded on a 6mm sterile Whatman filter paper disc placed on the agar layer. Pure topical composition samples were tested. About 5μl of the topical composition sample was loaded on a 6mm sterile Whatman filter paper disc placed on the agar layer. Sterile PBS was used as a negative control. Positive and negative controls were performed simultaneously. After 24 hours of exposure to the sample, the assay was terminated by adding MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide; Thiazolyl Blue) (Sigma M 5655) and incubated overnight in the dark. The next day, the cells were observed under a microscope and examined for the presence of crystals under the sample loading area. Samples that resulted in cell death were indicated by a clear zone of inhibition. The color was allowed to develop overnight and the zone of inhibition was measured. The readings of the samples were then scored based on comparisons with positive and negative controls according to the USP (United States Pharmacopeia) rating of the agar diffusion test (Table 2).

[0094] Table 2

[0095] Rating Responsiveness Description of the Reactive Region 0 none No detectable area around or under the specimen 1 slight There are some deformed or degenerated cells under the specimen 2 mild The area is limited to the area below the specimen 3 medium The area between 0.5cm and 1.0cm beyond the sample 4 serious The area beyond the sample is greater than 1.0cm

[0096] Stability analysis

[0097] The stability of the samples was analyzed using an accelerated stability test conducted at 45°C at 70% RH for a period of 3 months.

[0098] Cytocompatibility analysis

[0099] The cytocompatibility of the samples was evaluated using the sulforhodamine B (SRB) test. The value-added evaluation of the samples performed on a mouse fibroblast cell line (3T3) by the sulforhodamine B (SRB) test was designed to study the cytotoxic potential of the topical composition samples in terms of inhibiting cell growth compared to an internal reference standard. A stock solution of 100 mg / ml of the reference standard was prepared in sterile phosphate buffered saline (PBS). All concentrations were prepared by serial dilution and freshly prepared in phosphate buffered saline before use. The topical composition samples were tested at concentrations of 0.5%, 1%, 2.5%, and 5%. The stock solution was freshly prepared in dimethyl sulfoxide (DMSO) and vortexed. Further dilutions were prepared in DMSO. The excipients were controlled at the same time. Higher concentrations were limited by solubility. The cells were seeded into 96-well plates and cultured for 24 hours. After 24 hours, the test compound was added to each well in four times and cultured for 24 hours. After 24 hours, the cells were fixed, washed, and dried. The cells were stained with sulforhodamine B stain, washed, dried, and the stain dissolved in Tris (tris(hydroxymethylaminomethane)). The plates were read at 570 nm using a plate reader. The intensity of the color is proportional to the total protein, which is an indication of cell activity. Cytotoxicity / proliferation was scored based on comparison to untreated controls. A reference standard was used to indicate cytotoxicity and / or proliferation. The sample readings were scored based on comparison to a zero control (benchmark). The optical density of the zero control was considered to be 100% active. The percent activity of the sample was calculated compared to the control. The IC was also obtained from the dose response curve. 50 value.

[0100] Activity percentage = t / c x 100, where t is the optical density of the sample and c is the optical density of the zero control.

[0101] Gloss test analysis

[0102] The gloss test is used to evaluate the ability of a composition to provide gloss to the hair after application. A gloss meter is used to evaluate the refractive index of a hair care composition. The amount of light reflected from a surface of an object is used to measure the gloss level of a surface. Here, a hair sample is placed under the lens of the gloss meter before and after application of the sample, the gloss meter is operated at 20, 60, 85 degree angles, and the corresponding readings are recorded and analyzed.

[0103] Example 2

[0104] Sensory analysis: Sample 1 (A_89.8)

[0105] This example illustrates the sensory evaluation of Sample 1 (A_89.8) containing 89.8% MCT, 10% isopropyl myristate and 0.2% Vitamin E relative to commercial silicones (cyclopentasiloxane, dimethicone). Sensory analysis plays a vital role in understanding consumer acceptance of a product. The scores assessed by each volunteer for the sensory parameters of the samples (e.g., fragrance, texture, initial skin feel, radiance, absorption, skin feel during application, feel after application and effect on skin) were tabulated and analyzed to produce a composite score for each individual category (Tables 3 and Figure 1A ).

[0106] The individual scores of the nine volunteers for the above parameters recorded were tabulated and averaged to obtain a comprehensive score (cumulative score) for each individual parameter. The overall cumulative score of all parameters for each sample was then obtained as the average of the comprehensive scores for each parameter.

[0107] Table 3

[0108]

[0109] The above ratings of the volunteers demonstrate that, as shown in Table 2, Sample 1 (A_89.8) containing 89.8% MCT, 10% isopropyl myristate and 0.2% vitamin E provides a better sensory effect. Compared with silicone (3.2 for cyclopentasiloxane and 3.0 for dimethicone), Sample 1 (A_89.8) has the highest overall cumulative rating of 3.6 (Tables 3 and 4). Figure 1B ).

[0110] Moisturizing analysis: Comparison between sample 1 (A_89.8) and silicone (cyclopentasiloxane, dimethicone)

[0111] The moisturizing analysis of sample 1 (A_89.8) was evaluated relative to commercial silicones (cyclopentasiloxane and dimethicone). It is apparent from Figure 2 (A, B and C) that the moisturizing ability of sample 1 (A_89.8) is 6% to 7% higher than that of cyclopentasiloxane and dimethicone. The moisture content of sample 1 (A_89.8) after application was 24.5%, and remained at 22% 8 hours after application. While the moisture content of cyclopentasiloxane and dimethicone after application was 23%, 22.5%, respectively, and remained at 21% 8 hours after application. Therefore, it is apparent that the topical composition sample 1 (A_89.8) of the present invention exhibits an improved moisturizing effect on the skin, even 8 hours after application.

[0112] The stability of Sample 1 (A_89.8) was determined at 45°C and 70% RH, and the composition was found to be stable for at least 3 months under said conditions.

[0113] Skin reactivity analysis of sample 1 (A_89.8)

[0114] The skin reactivity of sample 1 (A_89.8) with positive control sample and negative control sample was evaluated by agar diffusion test. The purpose of the agar diffusion test is to study the reactivity by measuring the inhibition zone of the sample to the mouse fibroblast cell line (3T3). A total of 3 independent experiments were performed. The reactivity of the sample was evaluated by measuring the inhibition zone. The mouse fibroblast cell line (3T3) was used to test to study the effect of the sample for 24 hours. Table 4 shows the inhibition zone obtained by sample 1 (A_89.8) with positive control and negative control in three independent experiments. In addition, Table 5 shows the average value of three independent experiments. Then, as shown in Table 6, the readings of the sample were scored based on the comparison with the positive control and negative control according to the USP rating of the agar diffusion test.

[0115] Table 4

[0116]

[0117] Table 5

[0118]

[0119] Sample 1 (A_89.8) was found to have no inhibition zone at 100% concentration (Table 4). The average inhibition zone of the positive control was found to be 1.14 ± 0.06 cm (Table 5). The negative control was found to have no inhibition zone. Sample 1 (A_89.8) was scored under the experimental conditions shown in Table 6 and was found to have no inhibition zone when compared to the positive control ( Figure 3C ), the cells under loading sample 1 (A_89.8) were intact, without deformity or degeneration ( Figure 3A ); therefore, sample 1 (A_89.8) was found to be non-reactive and compatible with skin cells.

[0120] Table 6

[0121]

[0122] Cytocompatibility analysis of sample 1 (A_89.8)

[0123] The cytocompatibility of sample 1 (A_89.8) was evaluated by measuring cytotoxicity / proliferation using the sulforhodamine B test. A total of 3 independent experiments were performed for each sample. The ability of the sample to induce cytotoxicity was evaluated by the sulforhodamine B (SRB) method. The mouse fibroblast cell line (3T3) was used to test the effect of the sample for 24 hours. For the study, four concentrations ranging from 0.5% to 5% were used. For the reference standard, a concentration of 0.005% to 0.02% was used. The percentage activity of the topical composition and the reference standard was calculated. Table 7 shows the individual percentage activity of sample 1 and the reference standard in each experiment at different concentrations. The average value of the percentage activity of the reference standard and sample 1 was also tabulated (Table 8).

[0124] Table 7

[0125]

[0126]

[0127] Table 8

[0128]

[0129] The reference standard had a maximum activity of 90.40% ± 2.21 at 0.005%, which decreased in a dose-dependent manner to 20.34% ± 4.05 at 0.02% (Table 8 and Figure 4A ). Reference standard IC 50 On the other hand, sample 1 (A_89.8) induced 73.35% ± 2.06 cell activity at the lowest concentration of 0.5% (5 mg / ml), and 94.39% ± 9.16 cell activity at the highest concentration of 5% (50 mg / ml) (Table 8 and Table 9). Figure 4B ). No dose-dependent cytotoxicity was observed and the IC could not be determined. 50 It can be understood that sample 1 (A_89.8) has no cytotoxicity and is cell compatible.

[0130] Example 3

[0131] Sensory analysis of sample 2 (B_89.8)

[0132] Sample 2 (B_89.8), prepared as described in Example 1, containing 89.8% MCT, 10% coco-caprylate caprate, and 0.2% vitamin E, was subjected to sensory evaluation against commercial silicones (cyclopentasiloxane, dimethicone), and the scores recorded by the volunteers were combined. The scores assessed by each volunteer for the sensory parameters of the samples (e.g., fragrance, texture, initial skin feel, radiance, absorption, skin feel during application, feel after application, and effect on the skin) were tabulated and analyzed to produce a combined score for each individual category (Table 9).

[0133] The individual scores of the nine volunteers for the parameters recorded were tabulated and averaged to obtain a comprehensive score (cumulative score) for each individual parameter.Then, the overall cumulative score for all parameters of each sample was obtained as the average of the comprehensive scores for each parameter.

[0134] Table 9

[0135]

[0136] The volunteers' ratings proved that, as shown in Table 9 and Figure 5A Among the parameters shown, sample 2 (B_89.8) containing 89.8% MCT, 10% coco-caprylate caprate and 0.2 vitamin E provided better sensory effects. Compared with silicone (cyclopentasiloxane is 3.2 and dimethicone is 3.0), sample 2 (B_89.8) has the highest overall cumulative score of 3.4 (Table 9 and Table 10). Figure 5B ).

[0137] The stability of Sample 2 (B_89.8) was determined at 45°C and 70% RH, and the composition was found to be stable for at least 3 months under said conditions.

[0138] Moisturizing analysis: Comparison between sample 2 (B_89.8) and silicone (cyclopentasiloxane, dimethicone)

[0139] Moisturizing analysis of sample 2 (B_89.8) was evaluated relative to commercial silicones (cyclopentasiloxane, dimethicone). It is apparent from Figure 6 (A, B and C) that the moisturizing ability of sample 2 (B_89.8) is 7% to 8% higher than that of cyclopentasiloxane and dimethicone.

[0140] Skin reactivity analysis of sample 2 (B_89.8)

[0141] The skin reactivity of sample 2 (B_89.8) with positive control samples and negative control samples was evaluated by agar diffusion test. The agar diffusion test is used to study the reactivity by determining the inhibition zone of the sample to the mouse fibroblast cell line (3T3). A total of 3 independent experiments were performed. The reactivity of the sample was evaluated by measuring the inhibition zone. Table 10 shows the inhibition zone obtained for sample 2 (B_89.8) with positive controls and negative controls in three independent experiments. In addition, Table 11 shows the average value of three independent experiments. Then, as shown in Table 12, the readings of the sample were scored based on the comparison with the positive control and the negative control according to the USP rating of the agar diffusion test.

[0142] Table 10

[0143]

[0144] Table 11

[0145]

[0146] Sample 2 (B_89.8) was found to have no inhibition zone at 100% concentration (Table 10). The average inhibition zone of the positive control was found to be 1.14 ± 0.06 cm (Table 11). The negative control was found to have no inhibition zone. Sample 2 (B_89.8) was scored under the experimental conditions shown in Table 12 according to the guidelines of the United States Pharmacopoeia Biological Testing Regulations. In addition, when compared to the negative and positive controls ( Figure 7B and Figure 7C ) compared to the cells in loading sample 2 (B_89.8), it was found that the cells under loading sample 2 (B_89.8) were intact, without deformity or degeneration ( Fig. 7A ); therefore, sample 2 (B_89.8) was found to be unreactive.

[0147] Table 12

[0148]

[0149] Cytocompatibility analysis of sample 2 (B_89.8)

[0150] The cytocompatibility of sample 2 (B_89.8) was evaluated by measuring cytotoxicity / proliferation using the sulforhodamine B test. A total of 3 independent experiments were performed. The ability of the samples to induce cytotoxicity was evaluated by the sulforhodamine B (SRB) method. Mouse fibroblast cell lines (3T3) were used to test the effect of the samples for 24 hours. For sample 2 (B_89.8), four concentrations of 0.5% to 5% were used, depending on solubility. For reference standards, concentrations of 0.005% to 0.02% were used. Table 13 shows a summary of the activity percentages determined.

[0151] Table 13

[0152]

[0153] Table 14

[0154]

[0155] The reference standard had a maximum activity of 90.40% ± 2.21 at 0.005%, which decreased in a dose-dependent manner to 20.34% ± 4.05 at 0.02% (Table 14 and Fig. 8A ). Reference standard IC 50 The value was determined to be 0.0115%. Sample 2 (B_89.8) induced 68.61% ± 2.8 cell activity at the lowest concentration of 0.5% (5 mg / ml), and 80.80% ± 3.55 cell activity at the highest concentration of 5% (50 mg / ml) (Table 14 and Figure 8B ). There was no dose-dependent cytotoxicity, and the IC50 value could not be determined. Therefore, it can be understood that sample 2 (B_89.8) has no cytotoxicity and is cell compatible.

[0156] Comparative Example 1

[0157] Sensory analysis: Sample 3 (A_74.8)

[0158] The sensory evaluation of sample 3 (A_74.8) containing 74.8% MCT, 25% isopropyl myristate and 0.2% vitamin E was recorded and compared with commercial silicones (cyclopentasiloxane, dimethicone). The scores evaluated by each volunteer for the sensory parameters of the samples (e.g., fragrance, texture, initial skin feel, radiance, absorption, skin feel during application, feel after application and effect on skin) were tabulated and analyzed to obtain a comprehensive score for each individual category (Table 15).

[0159] The individual scores of the nine volunteers for the parameters recorded were tabulated and averaged to obtain a comprehensive score (cumulative score) for each individual parameter.Then, the overall cumulative score for all parameters of each sample was obtained as the average of the comprehensive scores for each parameter.

[0160] Table 15

[0161]

[0162]

[0163] It can be observed from Table 15 that in terms of sensory parameters, silicone was found to be more acceptable than sample 3 (A_74.8) comprising 74.8% MCT, 25% isopropyl myristate and 0.2% vitamin E. Sample 3 (A_74.8) had the lowest overall cumulative score of 2.9 (9.3) compared to commercial silicones (3.2 for cyclopentasiloxane and 3.0 for dimethicone). Fig. 9 ). This reduction in organoleptic effect can be attributed to the % (w / w) of isopropyl myristate used in the composition. It can be seen that the weight % of isopropyl myristate is greater than the specified weight % range of 1% to 15%, and it is confirmed that an increase in the weight % of isopropyl myristate leads to an undesirable effect of the composition. Therefore, it is essential that the ingredients are within the stated weight ranges so that the composition provides an enhanced organoleptic effect.

[0164] Moisture Analysis: Sample 3 (A_74.8)

[0165] Sample 3 (A_74.8) was evaluated for moisture retention analysis and from Fig.11 It can be clearly seen that the moisturizing ability of sample 3 (A_74.8) decreased after two hours of testing. It can be seen that the composition prepared outside the weight range does not provide improved moisturizing ability, but shows reduced properties. Therefore, it can be confirmed that the composition prepared by the weight range disclosed herein is suitable for topical compositions with enhanced cosmetic applicability.

[0166] Comparative Example 2

[0167] Sensory analysis: Sample 4 (B_74.8)

[0168] Sample 4 (B_74.8) containing 74.8% MCT, 25% coco-caprylate caprate and 0.2% vitamin E was subjected to sensory evaluation against commercial silicones (cyclopentasiloxane, dimethicone). The scores assessed by each volunteer for the sensory parameters of the samples (e.g., fragrance, texture, initial skin feel, radiance, absorption, skin feel during application, feel after application and effect on skin) were tabulated and analyzed to produce a composite score for each individual category (Table 16).

[0169] The individual scores of the nine volunteers for the parameters recorded were tabulated and averaged to obtain a comprehensive score (cumulative score) for each individual parameter.Then, the overall cumulative score for all parameters of each sample was obtained as the average of the comprehensive scores for each parameter.

[0170] Table 16

[0171]

[0172]

[0173] As can be understood from Table 16, in the sensory properties, silicone was found to be more acceptable than Sample 4 (B_74.8) comprising 74.8% MCT, 25% coco-caprylate caprate and 0.2% vitamin E; Sample 4 (B_74.8) had the lowest overall cumulative score of 2.9 (9.8) compared to silicone (3.7 for cyclopentasiloxane and 3.0 for dimethicone). Fig.10 ). This deterioration in sensory effect is due to the % (w / w) of coco-caprylate caprate used in the composition. Coco-caprylate caprate exceeds the specified weight % range of 1% to 15% and the composition produces undesirable effects. Therefore, the presence of all three ingredients within the stated weight ranges is essential to achieve enhanced sensory effects.

[0174] Moisturizing analysis: Sample 4 (B_74.8)

[0175] Sample 4 (B_74.8) was evaluated for moisture retention analysis and from Fig.11 It can be clearly seen that, similar to Sample 3 (A_74.8), Sample 4 (B_74.8) has decreased moisturizing ability after two hours of testing. Thus, compositions prepared outside of the weight ranges result in less desirable topical compositions, and again, it is critical to keep all three ingredients within the weight ranges described herein.

[0176] Comparative Example 3

[0177] Sensory analysis: Sample 5 (A_59.8)

[0178] The sensory evaluation of sample 5 (A_59.8) containing 59.8% MCT, 40% isopropyl myristate and 0.2% vitamin E was recorded relative to commercial silicones (cyclopentasiloxane, dimethicone). The scores evaluated by each volunteer for the sensory parameters of the samples (e.g., fragrance, texture, initial skin feel, shine, absorption, skin feel during application, feel after application and effect on skin) were tabulated and analyzed to produce a comprehensive score for each individual category (Table 17).

[0179] The individual scores of the nine volunteers for the parameters recorded were tabulated and averaged to obtain a comprehensive score (cumulative score) for each individual parameter.Then, the overall cumulative score for all parameters of each sample was obtained as the average of the comprehensive scores for each parameter.

[0180] Table 17

[0181]

[0182] Sample 5 (A_59.8) containing 59.8% MCT, 40% isopropyl myristate and 0.2% vitamin E did not have significant sensory capabilities when compared to silicones in terms of all properties as shown in Table 17. Sample 5 (A_59.8) had an overall cumulative score of 3.3 ( 0.10 for cyclopentasiloxane and 3.0 for dimethicone) compared to silicones (3.2 for cyclopentasiloxane and 3.0 for dimethicone). Fig.12 ). The results show that Fig.14 As can be seen from the scores of Sample 5, Sample 5 exhibits comparable organoleptic properties, but exhibits poorer moisturizing properties compared to the blank after 2 hours of application. In addition, it can be observed that Sample 5 (A_59.8) scores much lower than Sample 1 (A_89.8) in terms of fragrance, skin feel during application, and skin feel after application. This deviation in properties is mainly due to Sample 5 having a lower MCT% and higher isopropyl myristate than the described weight range. Therefore, in order for a topical composition to have improved organoleptic properties and moisturizing properties, it is critical that the ingredients are within the described ranges.

[0183] Comparative Example 4

[0184] Sensory analysis: Sample 6 (B_74.8)

[0185] Sample 6 (B-59.8) containing 59.8% MCT, 40% coco-caprylate caprate and 0.2% vitamin E and commercial silicones (cyclopentasiloxane, dimethicone) were subjected to sensory evaluation, and the scores evaluated by each volunteer for the sensory parameters of the samples (e.g., fragrance, texture, initial skin feel, gloss, absorption, skin feel during application, feel after application and effect on skin) were tabulated and analyzed to obtain a comprehensive score for each individual category (Table 18).

[0186] The individual scores of the nine volunteers for the parameters recorded were tabulated and averaged to obtain a comprehensive score (cumulative score) for each individual parameter.Then, the overall cumulative score for all parameters of each sample was obtained as the average of the comprehensive scores for each parameter.

[0187] Table 18

[0188]

[0189]

[0190] Sample 6 (B_59.8) had an overall cumulative score of 3.4 compared to silicone (3.2 for cyclopentasiloxane and 3.0 for dimethicone) (Tables 18 and Fig.13). However, it can also be observed that sample 6 (B_59.8) scored much lower than sample 2 (B_89.8) in terms of fragrance and absorption, and sample 6 scored lower overall compared to sample 2. This is because sample 6 has more coco-caprylate caprate and less MCT compared to sample 2. This deviation in the weight % of ingredients did not provide the desired sensory effect, despite showing better sensory effects than silicones. Therefore, it is essential that a composition that exhibits effective sensory properties should have ingredients within the weight ranges described herein.

[0191] Moisturizing analysis: Sample 6 (B_59.8)

[0192] Sample 6 (B_59.8) was evaluated for moisture retention analysis and from Fig.14 It can be clearly seen that Sample 6 ((B_59.8) has reduced moisturizing ability after two hours compared to the blank. Similar to Sample 5 above, Sample 6 also includes less MCT% and more Coco-Caprylate Caprate in the composition compared to the disclosed weight range. This deviation in weight % results in non-synergistic moisturizing ability, although the composition exhibits comparable sensory effects. Therefore, these examples demonstrate that compositions containing ingredients falling within the stated weight ranges are critical to providing the desired overall sensory and moisturizing effects to the skin.

[0193] Example 4

[0194] Skin care composition and hair care composition

[0195] The present invention provides a topical composition for topical application to keratinous tissues, i.e. for topical application to skin and hair. The skin care composition comprises medium chain triglycerides within the weight range disclosed herein with isopropyl myristate and vitamin E. Isopropyl myristate (a polar emollient) is suitable for use in skin cosmetics and is therefore preferred in the skin care composition. Thus, the skin care composition comprises 89.8% MCT, 10% isopropyl myristate and 0.2% vitamin E.

[0196] The hair care composition of the present invention comprises medium chain triglycerides within the weight ranges disclosed herein with coco caprylate caprate and vitamin E. Coco caprylate caprate (a fast spreading, low greasiness emollient) is suitable for use in hair care cosmetics and is therefore preferred in the hair care composition. Thus, the hair care composition comprises 89.8% MCT, 10% coco caprylate caprate and 0.2% vitamin E. The gloss test was used to evaluate the potential gloss and shiny appearance that the hair care composition can provide to the hair. The refractive index was measured at various angles and is tabulated in Table 19 below.

[0197] Table 19

[0198]

[0199] It is evident from the values ​​in Table 19 that the refractive index of the hair care sample increased significantly after application to the hair sample, especially at geometric angles 60 and 85. Therefore, it is evident that Sample 2 (B_89.8) can be effectively used in the hair care category to enhance hair shine and reduce flyaways and tangles.

[0200] In general, a topical composition of a skin care composition or a hair care composition comprising MCT in a weight percentage range of 70% to 95%, isopropyl myristate or coco-caprylate caprate in a weight percentage range of 1% to 15%, and vitamin E in a weight percentage range of 0.1% to 0.3% is essential for achieving a desired composition with enhanced moisturizing and nourishing effects on skin and hair. In addition, the specific working composition also exhibits an enhanced moisturizing effect compared to silicones (e.g., cyclopentasiloxane, dimethicone). Any slight deviation from the disclosed weight ranges fails to provide a composition with the desired sensory and moisturizing effects.

[0201] Advantages of the present invention

[0202] The present invention focuses on the development of non-toxic, safe, biodegradable topical compositions comprising medium chain triglycerides (MCT), isopropyl myristate or coconut oil alcohol caprylate caprate and microorganism E. The composition of the present invention is based on the combination of the above-disclosed naturally derived ingredients by weight percentage, which helps to form a film on the skin, thereby helping to improve the moisturizing ability and nourishing ability, and providing an enhanced sensory sensation. The composition of the present invention is a silicon-free composition, which avoids the problems existing in conventional cosmetic compositions containing silicone. The present invention provides a simple composition, which has a minimum of ingredients derived from natural resources and is therefore an environmentally friendly product. In addition, the present invention provides a simple method for preparing the composition, which makes the composition economically feasible. It was also found that the composition of the present invention is stable for at least 3 months and is found to be cell compatible. The present invention also provides a cosmetic preparation with an additive for topical application to the skin and hair. The composition of the present invention can be used to treat keratin tissue and provide enhanced moisturizing and nourishing effects to the skin and hair.

Claims

1. A topical composition comprising: a. 70% to 95% (w / w) triglycerides; b. 1% to 15% (w / w) C8 to C 16 Esters of fatty acids; and c. 0.1% to 0.3% (w / w) vitamin E, in, Triglycerides are composed of C6 to C 12 Medium chain triglycerides of fatty acids.

2. The composition according to claim 1, wherein C8 to C 16 The esters of fatty acids are isopropyl myristate or caprylate caprate.

3. The composition according to claim 1, wherein The triglycerides have an acid value of less than 0.1 and a color index of less than 50.

4. The composition according to claim 1, wherein The composition is used for skin care or hair care.

5. The composition according to claim 1, wherein The composition is chemically stable at 45°C and 70% RH for at least 3 months.

6. The composition according to claim 1, wherein The composition is stable and exhibits cytocompatibility.

7. The composition according to claim 1, wherein The composition further comprises an ingredient selected from the group consisting of an antimicrobial, an antibacterial, an antifungal, an antiprotozoal, and an antiviral agent.

8. A method for preparing the composition according to claim 1, comprising: At a temperature ranging from 20°C to 60°C, a stoichiometric ratio of triglycerides, C8 to C 16 Fatty acid esters are contacted with vitamin E, wherein the triglyceride is a 12 Medium chain triglycerides of fatty acids.

9. A cosmetic preparation comprising the composition according to claim 1 and an additive.

10. The preparation according to claim 9, wherein The additive is selected from preservatives, pH adjusters, chelating agents or co-solvents.

11. The formulation of claim 9, which is applied topically to the hair or skin.

12. A method of treating keratinous tissue of a subject, the method comprising topically applying the composition according to claim 1 or the cosmetic formulation according to claim 9 to the keratinous tissue.

13. A method of treating hair, the method comprising topically applying the composition according to claim 1 or the cosmetic preparation according to claim 9 to hair in need of treatment, wherein: The compositions or formulations are applied topically to the hair to treat the hair.

14. A method for moisturizing the skin, the method comprising applying an effective amount of the composition according to claim 1 or the cosmetic preparation according to claim 9 to the skin.

15. Use of a composition according to claim 1 or a cosmetic preparation according to claim 9.

16. Use of a composition according to claim 1 or a cosmetic preparation according to claim 9 for treating the hair or skin and providing a moisturizing effect.

17. A skin care topical composition comprising: a. 70% to 95% (w / w) triglycerides; b. 1% to 15% (w / w) isopropyl myristate; and c. 0.1% to 0.3% (w / w) vitamin E, in, The triglycerides are C6 to C 12 Medium chain triglycerides of fatty acids.

18. A hair care topical composition comprising: a. 70% to 95% (w / w) triglycerides; b. 1% to 15% (w / w) caprylate caprate; and c. 0.1% to 0.3% (w / w) vitamin E, in, The triglycerides are C6 to C 12 Medium chain triglycerides of fatty acids.

Images