An improved multi-purpose pipeline for artificial liver blood purification

Abstract

The present invention discloses an improved multi-purpose pipeline for artificial liver blood purification, which includes: The basic treatment unit includes an output pipeline, an input pipeline, a first separator, a plasma pipeline and a fluid infusion port; One end of the first separator is connected to the output pipeline, and the other end is connected to the input pipeline; The side wall of the first separator is connected to the plasma pipeline; One end of the input pipeline is communicated with the fluid infusion port; One end of the plasma pipeline is provided with a first discharge port; The first additional unit includes an injection pipe, a second separator and a relay pipeline; One end of the second separator is connected to the plasma pipeline through the injection pipe, and the other end is connected to the input pipeline through the relay pipeline; The second additional unit includes a side output pipe and a first delivery pipe; One end of the side output pipe is communicated with the second separator, and the other end is communicated with the input pipeline; One end of the first delivery pipe is communicated with the relay pipeline, and the other end is provided with a second discharge port.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical devices, and particularly relates to an improved multi-purpose pipeline for artificial liver blood purification. Background Art

[0002] The artificial liver blood purification treatment technology is an important means for treating liver failure. Its treatment is completed through an extracorporeal circulation system to perform functions such as separation, replacement, adsorption, and mass exchange, temporarily replacing part of the liver function, removing harmful substances, supplementing essential substances, creating conditions for hepatocyte regeneration, and can also serve as a bridge for liver transplantation surgery. The artificial liver treatment process is complex and highly operable. The installation and pre-flushing of the extracorporeal circulation pipeline before treatment are both completed by the operating nurse, with a large workload. With the continuous update of the artificial liver blood purification treatment mode and technology, the existing pipelines matched with fixed modes cannot fully meet the needs of the current clinical treatment development and transformation. Therefore, there will be a phenomenon of using two sets of pipelines to piece together to achieve a complex treatment or carry out a new treatment. This pipeline connection method, on the one hand, increases the workload of the operator, increases the operation links, and increases the risk of contamination; on the other hand, it increases the complexity of nursing operations, increases the difficulty, and it is difficult to achieve the homogenization of clinical nursing operation quality, further increasing the treatment risk and affecting the treatment safety. Even to a certain extent, it restricts the development of complex and new modes.

[0003] The present invention aims at the above problems and provides an improved multi-purpose pipeline for artificial liver blood purification. Summary of the Invention

[0004] In order to overcome the problems raised in the background art, the present invention provides an improved multi-purpose pipeline for artificial liver blood purification.

[0005] An improved multi-purpose pipeline for artificial liver blood purification, which comprises:

[0006] A basic treatment unit, including an output pipeline, an input pipeline, a first separator, a plasma pipeline, and a fluid infusion port; one end of the first separator is connected to the output pipeline, and the other end is connected to the input pipeline; the side wall of the first separator is connected to the plasma pipeline; one end of the input pipeline is communicated with the fluid infusion port; a fluid infusion valve is provided on the fluid infusion port; a first discharge port is provided at the end of the plasma pipeline far from the first separator; a first discharge valve is provided on the first discharge port;

[0007] A first additional unit, including an injection tube, a second separator, and a relay pipeline; one end of the second separator is connected to the plasma pipeline through the injection tube, and the other end is connected to the input pipeline through the relay pipeline; an injection valve is provided inside the injection tube;

[0008] The second additional unit includes a side output pipe and a first delivery pipe; one end of the side output pipe is communicated with the second separator, and the other end is communicated with the input pipeline; one end of the first delivery pipe is communicated with the relay pipeline, and the other end is provided with a second discharge port; a second discharge valve is provided on the second discharge port; a first delivery valve is provided inside the first delivery pipe; a first side output valve is provided inside the side output pipe;

[0009] The third additional unit includes a circulation pipeline; one end of the circulation pipeline is communicated with the side output pipe, and the other end is communicated with the side wall of the second separator; a first circulation valve and a second circulation valve are provided inside the circulation pipeline.

[0010] Furthermore, a reflux pipeline is further included; one end of the reflux pipeline is connected to the input pipeline, and the other end is connected to the liquid supplement port.

[0011] Furthermore, a second side output valve, a third side output valve and a four-way joint are further provided inside the side output pipe; the four-way joint is connected in series inside the side output pipe and is located between the second side output valve and the third side output valve; the other two interfaces of the four-way joint are connected in series inside the relay pipeline; the first side output valve is located between the second side output valve and the second separator.

[0012] Furthermore, the connection point between the circulation pipeline and the side output pipe is between the second side output valve and the third side output valve.

[0013] Furthermore, the side output pipe is connected to the input pipeline through a return slurry pump.

[0014] Furthermore, the relay pipeline includes a relay pipe main body, a second delivery pipe and a third delivery pipe; the side output pipe, the second delivery pipe and the third delivery pipe are connected through a four-way joint; one end of the second delivery pipe away from the side output pipe is communicated with the relay pipe main body; one end of the third delivery pipe is communicated with the side output pipe, and the other end is communicated with the input pipeline; a second delivery valve is provided inside the second delivery pipe; a fourth delivery valve is provided inside the third delivery pipe.

[0015] Furthermore, a first pump body is provided inside the output pipeline.

[0016] Furthermore, a second pump body is provided inside the plasma pipeline.

[0017] Furthermore, a third pump body is provided inside the circulation pipeline.

[0018] Furthermore, an adsorption device is provided inside the circulation pipeline.

[0019] Advantages of the present invention:

[0020] 1. The PE treatment, i.e., plasma exchange treatment, can be carried out using the basic treatment unit. During the treatment, the patient's blood enters the first separator through the output pipeline. The first separator separates the plasma component and the cell component in the whole blood according to a certain ratio. The plasma is discharged through the plasma pipeline and the first discharge port. The cell component separated by the first separator enters the input pipeline through the first output pipe. At the same time, the replenishing fluid (plasma / plasma substitute) enters the input pipeline from the replenishing fluid port. After the replenishing fluid is mixed with the cell component, it is returned to the human body through the input pipeline.

[0021] 2. Open the injection valve and close the first discharge valve, then connect the basic treatment unit with the first additional unit, and adsorption treatment can be carried out, such as DPMAS, bilirubin adsorption treatment, plasma perfusion treatment, etc. During the treatment, the patient's blood enters the first separator through the output pipeline. Part of the plasma in the first separator is separated from the whole blood. The plasma enters the second separator through the plasma pipeline. After the plasma passes through the second separator for adsorption / perfusion, it is injected into the input pipeline through the relay pipeline. The cell component separated by the first separator enters the input pipeline through the first output pipe and is mixed with the plasma after adsorption / perfusion. Then the input pipeline returns to the human body.

[0022] 3. Open the first transfer valve, the first side output valve, the second side output valve, the third side output valve, and the second discharge valve, and close the second transfer valve, then connect the basic treatment unit with the first additional unit and the second additional unit, and the DFPP treatment, i.e., double plasma exchange, can be carried out. During the treatment, the patient's blood enters the first separator through the output pipeline. The first separator separates the blood cells and the plasma. The plasma enters the second separator through the plasma pipeline. The plasma separated by the second separator flows through the plasma component separator with a pore size smaller than that of the plasma separator. The molecules in the plasma larger than the pore size of the plasma component separator membrane cannot pass through the membrane pore two and are intercepted and then discharged through the second discharge port. The cell component separated by the first separator enters the input pipeline through the first output pipe. At the same time, the plasma that has completed filtration through the second separator enters the input pipeline through the side output pipe. The replenishing fluid port replenishes the replacement fluid (plasma, albumin solution, other plasma substitutes, etc.) into the input pipeline. After the plasma that has completed filtration, the replacement fluid, and the cell component are mixed, they are returned to the human body through the input pipeline.

[0023] 4. Open the first circulation valve and the second circulation valve, and close the second discharge valve and the second side output valve, then the basic treatment unit is connected to the first additional unit, the second additional unit, and the third additional unit, and a new adsorption treatment can be carried out; during the treatment, the patient's blood enters the first separator through the output pipeline. The first separator 5 separates part of the plasma from the whole blood. The plasma enters the second separator through the plasma pipeline, and then enters the input pipeline through the relay pipeline. The blood cells separated by the first separator enter the input pipeline through the first output pipe. After the filtered plasma and cell components are mixed, they return to the human body through the input pipeline; when the adsorption device is an adsorber, the second separator is a plasma component separator. At this time, the macromolecular substances in the plasma that are larger than the membrane pore size of the plasma component separator are intercepted and enter the adsorption device through the circulation pipeline for repeated adsorption treatment. When the adsorption device is a biological device, the second separator is a plasma component separator or a cell filter. The biological material in the biological device can enter the second separator repeatedly through the circulation pipeline, playing a role in preventing biological cell components from entering the body; 5. In summary, the present invention can control the connection and closing of different pipelines by opening and closing different valves on a single pipeline, realize different treatment schemes, effectively reduce the workload and operation links of the operator, and reduce the risk of contamination; reduce the difficulty of nursing operations, realize the homogenization of the quality of clinical nursing operations, and further ensure the treatment safety. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 It is a schematic structural diagram of a multi-purpose pipeline for implementing the present invention;

[0025] Figure 2 It is a schematic structural diagram of the first use mode of a multi-purpose pipeline for implementing the present invention;

[0026] Figure 3 It is a schematic structural diagram of the second use mode of a multi-purpose pipeline for implementing the present invention;

[0027] Figure 4 It is a schematic structural diagram of the third use mode of a multi-purpose pipeline for implementing the present invention;

[0028] Figure 5 It is a schematic structural diagram of the fourth use mode of a multi-purpose pipeline for implementing the present invention;

[0029] In the figure, 1 is the human body; 2 is the output pipeline; 3 is the input pipeline; 4 is the return pipeline; 5 is the first separator; 6 is the plasma pipeline; 7 is the second separator; 8 is the relay pipeline; 9 is the circulation pipeline; 10 is the fluid infusion port; 21 is the first fluid infusion port; 22 is the first sampling port; 23 is the first pump body; 24 is the anticoagulation port; 25 is the arterial pot; 31 is the venous pot; 32 is the detector; 33 is the second sampling port; 34 is the second pressure detection port; 41 is the return slurry pump; 42 is the warmer; 401 is the first return valve; 402 is the second return valve; 51 is the first output pipe; 52 is the separator pressure measurement port; 61 is the first discharge port; 62 is the blood leakage detection component; 63 is the second pump body; 64 is the plasma pot; 601 is the first discharge valve; 641 is the plasma pressure measurement port; 71 is the injection pipe; 72 is the side output pipe; 711 is the injection valve; 721 is the first side output valve; 722 is the second side output valve; 723 is the third side output valve; 801 is the first delivery pipe; 802 is the second delivery pipe; 803 is the second delivery valve; 804 is the third delivery valve; 805 is the fourth delivery valve; 806 is the third delivery pipe; 807 is the first delivery valve; 808 is the four-way joint; 91 is the second discharge port; 92 is the circulation sampling port; 93 is the third pump body; 95 is the adsorption device; 911 is the second discharge valve; 901 is the first circulation valve; 902 is the second circulation valve; 101 is the fluid infusion valve. Detailed implementation manners

[0030] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. The present invention can also be implemented or applied through other different specific implementation manners. Without conflict, the features in the following embodiments and the embodiments can be combined with each other. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts belong to the scope of protection of the present invention.

[0031] In the description of the present invention, it should be understood that the orientation or positional relationship indicated by the terms "upper", "lower", "front", "rear", "inner", "outer", etc. is based on the orientation or positional relationship shown in the accompanying drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation to the present invention.

[0032] In addition, the terms "first" and "second" are for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the quantity of the indicated technical features. Thus, features defined with "first" and "second" may explicitly or implicitly include one or more of such features. In the description of the present invention, "a plurality of" means two or more unless otherwise specifically defined.

[0033] Embodiment 1

[0034] As Figure 1 shown, an improved multi-purpose pipeline for artificial liver blood purification, which comprises:

[0035] A basic treatment unit, including an output pipeline 2, an input pipeline 3, a first separator 5, a plasma pipeline 6 and a liquid supplement port 10; one end of the first separator 5 is connected to the output pipeline 2, and the other end is connected to the input pipeline 3; the side wall of the first separator 5 is connected to the plasma pipeline 6; one end of the input pipeline 3 is communicated with the liquid supplement port 10; a liquid supplement valve 101 is provided on the liquid supplement port 10; one end of the plasma pipeline 6 far from the first separator 5 is provided with a first discharge port 61; a first discharge valve 601 is provided on the first discharge port 61;

[0036] A first additional unit, including an injection pipe 71, a second separator 7 and a relay pipeline 8; one end of the second separator 7 is connected to the plasma pipeline 6 through the injection pipe 71, and the other end is connected to the input pipeline 3 through the relay pipeline 8; an injection valve 711 is provided inside the injection pipe 71;

[0037] A second additional unit, including a side output pipe 72 and a first delivery pipe 801; one end of the side output pipe 72 is communicated with the second separator 7, and the other end is communicated with the input pipeline 3; one end of the first delivery pipe 801 is communicated with the relay pipeline 8, and the other end is provided with a second discharge port 91; a second discharge valve 911 is provided on the second discharge port 91; a first delivery valve 807 is provided inside the first delivery pipe 801; a first side output valve 721 is provided inside the side output pipe 72;

[0038] A third additional unit, including a circulation pipeline 9; one end of the circulation pipeline 9 is communicated with the side output pipe 72, and the other end is communicated with the side wall of the second separator 7; a first circulation valve 901 and a second circulation valve 902 are provided inside the circulation pipeline 9.

[0039] A reflux pipeline 4; one end of the reflux pipeline 4 is connected to the input pipeline 3, and the other end is connected to the liquid supplement port 10.

[0040] Further, a second side output valve 722, a third side output valve 723 and a four-way joint 808 are also provided inside the side output pipe 72; the four-way joint 808 is connected in series inside the side output pipe 72 and is located between the second side output valve 722 and the third side output valve 723; the other two interfaces of the four-way joint 808 are connected in series inside the relay pipe 8; the first side output valve 721 is located between the second side output valve 722 and the second separator 7.

[0041] Specifically, the connection point between the circulation pipe 9 and the side output pipe 72 is between the second side output valve 722 and the third side output valve 723.

[0042] The side output pipe 72 is connected to the input pipe 3 through the return slurry pump 41. Turning on the return slurry pump 41 can pump the liquid in the side output pipe 72 into the input pipe 3.

[0043] Further, the relay pipe 8 includes a relay pipe main body, a second delivery pipe 802 and a third delivery pipe 806; the side output pipe 72, the second delivery pipe 802 and the third delivery pipe 806 are connected through the four-way joint 808; one end of the second delivery pipe 802 away from the side output pipe 72 is communicated with the relay pipe main body; one end of the third delivery pipe 806 is communicated with the side output pipe 72, and the other end is communicated with the input pipe 3; a second delivery valve 803 is provided inside the second delivery pipe 802; a fourth delivery valve 805 is provided inside the third delivery pipe 806.

[0044] Specifically, one end of the third delivery pipe 806 is communicated with the side output pipe 72, and the other end is communicated with the return pipe 4. One end of the side output pipe 72 away from the second separator 7 is communicated with the return pipe 4.

[0045] Specifically, the four-way joint 808 is connected in series inside the side output pipe 72 and is located between the second side output valve 722 and the third side output valve 723; the other two interfaces of the four-way joint 808 are respectively connected to the second delivery pipe 802 and the third delivery pipe 806. Through the third delivery pipe 806, the liquid can bypass the return slurry pump 41 and enter the inside of the input pipe 3.

[0046] Specifically, a first pump body 23 and an arterial kettle 25 are provided inside the output pipe 2. The first pump body 23 continuously sucks blood from the patient's body through the output pipe 2 and passes through the arterial kettle 25. The arterial kettle 25 is communicated with the first separator 5. The blood inside the arterial kettle 25 will enter the inside of the first separator 5. The first separator 5 separates the blood into plasma and cell components. The cell components enter the input pipe 3 through the first output pipe 51 and flow back into the human body 1. The plasma separated by the first separator 5 will enter the inside of the plasma pipe 6.

[0047] Specifically, the cell components enter the input pipe 3 and flow back into the human body 1 through the first output pipe 51, the venous kettle 31 and the bubble detector 32 in sequence

[0048] In some embodiments of the present application, a first liquid replenishing port 21 is further provided inside the output pipeline 2, and replacement liquid can be replenished into the output pipeline 2 through the first liquid replenishing port 21.

[0049] Preferably, an anticoagulation port 24 is further provided inside the output pipeline 2, and the anticoagulation port 24 is connected to a first anticoagulation pump to prevent blood coagulation during extracorporeal circulation.

[0050] Furthermore, a first sampling port 22 is provided inside the output pipeline 2, and a patient blood sample can be collected through the first sampling port 22 for detection and analysis.

[0051] Furthermore, a pressure detection device is further provided inside the output pipeline 2 to detect the blood sampling pressure / arterial pressure inside the output pipeline 2.

[0052] In the illustrative embodiment of the present application, a second pump body 63 is provided inside the plasma pipeline 6. The second pump body 63 draws plasma from the first separator 5. At this time, the first discharge valve 601 is opened and the injection valve 711 is closed, and the plasma is discharged through the first discharge port 61. When the injection valve 711 is opened and the first discharge valve 601 is closed, the basic treatment unit is connected to the first additional unit, and the plasma can enter the second separator 7 along the injection pipe 71.

[0053] Furthermore, a blood leakage detection component 62 is further provided inside the plasma pipeline 6 to automatically detect whether the first separator 5 has a membrane rupture.

[0054] Furthermore, a plasma pot 64 is further provided inside the plasma pipeline 6, and the second pump body 63 sucks the plasma from the first separator 5 and stores it / passes through the inside of the plasma pot 64.

[0055] Preferably, a plasma pressure measurement port 641 is provided on the plasma pot 64, and the pressure inside the plasma pot 64 can be measured through the plasma pressure measurement port 641, so as to obtain the internal pressure data of the plasma pipeline 6.

[0056] In some examples of the present application, a third pump body 93 is provided inside the circulation pipeline 9. The function of the third pump body 93 is to maintain the liquid circulation inside the circulation pipeline 9.

[0057] In the specific example of the present application, an adsorption device 95 is further provided inside the circulation pipeline 9. The liquid inside the circulation pipeline 9 will carry out the filter residues intercepted by the second separator 7 and transport them to the inside of the adsorption device 95 during the circulation process, so as to maintain the filtering ability and filtering effect of the second separator 7.

[0058] The interior of the input pipeline 3 is provided with a venous chamber 31, a detector 32 and a second sampling port 33; the cell components separated by the first separator 5 enter the venous chamber 31 through the first output pipe 51, and the replenishing fluid (such as plasma / albumin solution / plasma bag supplies, etc.) transmitted by the return pipeline 4 also enters the venous chamber 31. After the cell components and plasma are mixed inside the venous chamber 31, they will enter the human body 1 through the input pipeline 3.

[0059] The venous chamber 31 is detachably connected to the input pipeline 3. When blood clotting occurs in the venous chamber 31, that is, when the second pressure detection port 34 on the venous chamber 31 detects an increase in the internal pressure of the venous chamber 31, the first output pipe 51, the return pipeline 4, and the input pipeline 3 are cut off, and a new venous chamber 31 is replaced.

[0060] The function of the detector 32 is as follows:

[0061] Detect that the liquid inside the venous chamber 31 is too little, or even the venous chamber 31 is empty. Detect whether there are air bubbles in the mixed liquid.

[0062] The function of the second sampling port 33 is as follows: through the second sampling port 33, a liquid sample after mixing of blood cells and plasma can be collected for detection and analysis.

[0063] The interior of the return pipeline 4 is provided with a return plasma pump 41 and a warmer 42. When replenishing fluid (such as plasma / albumin solution / plasma bag supplies, etc.) is input through the replenishing fluid port 10, the return plasma pump 41 is turned on, and the replenishing fluid can be pumped into the interior of the venous chamber 31 through the replenishing fluid port 10 and the return pipeline 4.

[0064] The function of the warmer 42 is as follows: raise the temperature of the plasma to the human body temperature 1 to prevent discomfort to the patient when the plasma is transfused back into the human body 1.

[0065] Furthermore, a separation valve is provided inside the return pipeline 4. The separation valve is located between the venous chamber 31 and the warmer 42.

[0066] The interior of the return pipeline 4 is also provided with a first return valve 401 and a second return valve 402. Different treatment modes can be switched through the first return valve 401 and the second return valve 402.

[0067] Open the injection valve 711 and close the first discharge valve 601, then connect the basic treatment unit and the first additional unit, and DPMAS treatment can be carried out, that is, dual plasma molecular adsorption blood purification.

[0068] Open the first delivery valve 807, the first side output valve 721, the second side output valve 722, the third side output valve 723, the second discharge valve 911, and close the second delivery valve 803, then connect the basic treatment unit with the first additional unit and the second additional unit, and DFPP treatment can be carried out, that is, dual plasma exchange.

[0069] Open the first circulation valve 901 and the second circulation valve 902, and close the second discharge valve 911 and the second side output valve 722, then the basic treatment unit is connected to the first additional unit, the second additional unit, and the third additional unit, and a new adsorption treatment can be carried out.

[0070] By opening and closing each valve, the treatment plan can be changed. One set of pipelines can achieve the random switching of multiple treatment modes, avoiding the situation that two sets of pipelines need to be pieced together when completing complex modes at present, and avoiding the situation that the artificial liver blood purification machine cannot complete the priming due to the piecing of pipelines. First, it reduces the consumption of consumables. Second, it avoids the human intervention link in manual priming and reduces the possibility of pollution. Third, it reduces the installation and priming operation difficulty, which is beneficial to improving the operability, quickly promoting homogenization, and improving the treatment safety.

[0071] Applicable to multiple modes: The improved pipeline can not only be applicable to multiple mature-mode artificial liver treatments, but also be applicable to the development of new adsorption treatment, complex-mode treatment, and bioartificial liver treatment.

[0072] The venous pot 31 and the pipeline can be replaced: Due to the change of the artificial liver blood purification treatment mode, the complexity increases, the treatment time is prolonged, and it may even last for more than 8 hours. In the extracorporeal circulation pipeline 9, especially the incidence of thrombosis in the venous pot 31 will also increase with the prolongation of time. It is manifested as the increase of the instrument pressure during the treatment, and even the situation that the pipeline is blocked by blood coagulation and the treatment cannot be carried out. A detachable end design is carried out in the venous pipeline, breaking the conventional one-piece pipeline form. Before the thrombosis of the venous pot 31 causes blood coagulation in the pipeline, the independent part of the pipeline assembly can be replaced, so that it is not necessary to replace the first separator 5, the second separator 7, and the whole set of treatment pipelines due to the blockage of the venous pipeline. Avoid unplanned disconnection from the machine and unable to achieve the expected treatment goal; avoid increasing the bleeding risk due to the consumption of coagulation substances in the patient's body and reduce the economic loss.

[0073] A detachable end design is carried out in the venous pipeline, breaking the conventional one-piece pipeline form. When thrombosis occurs in the venous pot 31, the independent part of the pipeline assembly can be replaced, so that it is not necessary to replace the primary membrane, the secondary membrane, and the whole set of treatment pipelines due to the blockage of the venous pipeline. In this way, it can not only reduce the medical cost and the patient's expense, but also reduce the loss of blood loss and coagulation substance consumption caused by pipeline blood coagulation to the patient, and can also reduce the workload and time cost of the operator for reinstalling the pipeline.

[0074] Convenient management: Patients with liver failure are in a critical condition with rapid changes, often requiring temporary changes in treatment plans for emergency treatment. There are many types of non-biological artificial liver treatments, and due to different treatment modes, the pipelines corresponding to a certain treatment are also different. This will result in a large number and variety of pipelines stored in the department. Since the usage frequency and quantity of pipelines cannot be predicted, it is easy to have a situation where although the total quantity of stored pipelines is not small, the pipeline models are incomplete or even the pipelines expire. In this case, on the one hand, it increases the workload of management personnel, and on the other hand, it may even affect the treatment of patients. The improved pipeline can be applicable to multiple treatment modes with a set of pipelines, relieving the pressure on nursing managers.

[0075] Example 2

[0076] As Figure 2 shown, it is an improved multi-purpose pipeline for artificial liver blood purification during plasma exchange treatment. At this time, the first discharge valve 601, the first reflux valve 401, the second reflux valve 402, the liquid supplement valve 101, the first pump body 23, and the second pump body 63 are opened, and the injection valve 711 and the third side output valve 723 are closed.

[0077] During the treatment process, the patient's blood is driven by the first pump body 23 and enters the first separator 5 through the output pipeline 2. The first separator 5 separates part of the plasma from the whole blood. The plasma is discharged through the plasma pipeline 6 and the first discharge port 61 under the drive of the second pump body 63. The cell components separated by the first separator 5 enter the venous chamber 31 through the first output pipe 51. At the same time, the liquid supplement port 10 inputs a liquid supplement (plasma / albumin solution / plasma bag supplies, etc.) to the second pump body 63. After the liquid supplement is mixed with the blood cells, it returns to the human body 1 through the input pipeline 3.

[0078] During this process, the patient's blood samples can be collected through the first sampling port 22 and the second sampling port 33 for detection and analysis as needed. The warmer 42 raises the temperature of the plasma to the human body temperature 1, reducing the discomfort of the patient when the plasma is transfused back into the human body 1.

[0079] The first liquid supplement port 21 can, on the one hand, serve as a liquid supplement passage for the patient to infuse liquid to supplement blood volume during the treatment, and on the other hand, can be connected to the liquid to complete the blood return after the machine is turned off.

[0080] Multiple pressure detection ports are provided inside the output pipeline 2, and the pressure at different positions inside the output pipeline 2 can be detected through different pressure detection ports.

[0081] The pressure inside the plasma chamber 64 can be measured through the plasma pressure detection port 641, so as to obtain the internal pressure data of the plasma pipeline 6. At the same time, the internal pressure of the first separator 5 is detected through the separator pressure detection port 52 located on the side wall of the first separator 5.

[0082] During the treatment process, the plasma containing high concentrations of bilirubin and toxic substances is discarded, and replacement fluid (plasma / albumin solution / plasma bag supplies, etc.) is infused into the patient's body through the replenishment port 10 to help the patient remove toxins.

[0083] Example 3

[0084] As Figure 3 shown, it is an improved multi-purpose pipeline for artificial liver blood purification for dual plasma molecular adsorption blood purification treatment.

[0085] At this time, the second reflux valve 402, injection valve 711, second delivery valve 803, third delivery valve 804, fourth delivery valve 805, first pump body 23, and second pump body 63 are opened, and the first reflux valve 401, first discharge valve 601, replenishment valve 101, second side output valve 722, third side output valve 723, first delivery valve 807, and return slurry pump 41 are closed.

[0086] During the treatment process, the patient's blood is driven by the first pump body 23 and enters the first separator 5 through the output pipeline 2. The first separator 5 separates part of the plasma from the whole blood. The separated plasma is driven by the second pump body 63 and enters the plasma pot 64 through the plasma pipeline 6. The plasma inside the plasma pot 64 enters the second separator 7. After the second separator 7 filters the plasma, it is injected into the venous pot 31 through the relay pipeline 8 and the reflux pipeline 4. During this process, the plasma separated by the first separator 5 enters the adsorption device 95, and the bilirubin and toxic substances in the plasma are adsorbed in the adsorption device 95. The adsorbed plasma enters the inside of the venous pot 31 through the relay pipeline 8 and the reflux pipeline 4, mixes with the blood cells, and then returns to the patient's body through the input pipeline 3.

[0087] The blood cells separated by the first separator 5 enter the venous pot 31 through the first output pipe 51, mix with the plasma after adsorption, and the mixed liquid returns to the patient's body through the input pipeline 3.

[0088] During the treatment process, the second separator 7 adsorbs the bilirubin and toxic substances in the plasma to help the patient remove the high bilirubin components and toxic substances in the blood.

[0089] Specifically, the second separator 7 is a new type of adsorption device 95.

[0090] Example 4

[0091] As Figure 4 shown, it is an improved multi-purpose pipeline for artificial liver blood purification for dual plasma exchange treatment.

[0092] At this time, open the first reflux valve 401, the second reflux valve 402, the injection valve 711, the first transfer valve 807, the first side output valve 721, the second side output valve 722, the third side output valve 723, the second discharge valve 911, the liquid supplement valve 101, the injection valve 711, the first pump body 23, the second pump body 63, and the return slurry pump 41, and close the first discharge valve 601, the second transfer valve 803, the third transfer valve 804, and the fourth transfer valve 805.

[0093] During the treatment process, the patient's blood is driven by the first pump body 23 and enters the first separator 5 through the output pipeline 2.

[0094] The first separator 5 separates part of the plasma from the whole blood. The plasma enters the second separator 7 through the plasma pipeline 6. The separated plasma flows through the second separator 7 (plasma component separator) with a pore size smaller than that of the first separator 5. Small molecules in the plasma that are larger than the pore size of the plasma component separator membrane can pass through the membrane pores and converge into the venous pot 31 for transfusion back into the body. The second separator 7 discharges the plasma containing pathogenic substances with larger molecular weights after filtration through the second discharge port 91.

[0095] The blood cells separated by the first separator 5 enter the venous pot 31 through the first output pipe 51. At the same time, the supplementary liquid (plasma / albumin solution / plasma bag supplies, etc.) enters through the liquid supplement port 10 and passes through the venous pot 31. The filtered plasma, supplementary liquid, and blood cells are mixed and then return to the human body 1 through the input pipeline 3.

[0096] During the treatment process, the second separator 7 removes pathogenic substances with larger molecular weights (antibodies, antigens, lipoproteins, etc.) in the plasma, improving the internal environment of the body. The same amount of supplementary liquid as the discarded waste liquid is supplemented to the venous pot 31 through the liquid supplement port 10.

[0097] Preferably, the flow rate of the waste plasma discharged through the second discharge port 91 is equal to the flow rate of the plasma supplemented to the venous pot 31 through the liquid supplement port 10.

[0098] Example 5

[0099] As Figure 5 shown, it is an improved multi-purpose pipeline for artificial liver blood purification in novel adsorption treatment.

[0100] At this time, open the first reflux valve 401, the second reflux valve 402, the injection valve 711, the first side output valve 721, the third side output valve 723, the second transfer valve 803, the third transfer valve 804, the liquid supplement valve 101, the injection valve 711, the first pump body 23, the second pump body 63, and the return slurry pump 41, and close the first discharge valve 601, the second side output valve 722, the fourth transfer valve 805, the second discharge valve 911, and the first transfer valve 807.

[0101] During the treatment process, the patient's blood is driven by the first pump body 23 and enters the first separator 5 through the output pipeline 2. The first separator 5 separates part of the plasma from the whole blood. The plasma enters the second separator 7 through the plasma pipeline 6. When the adsorption device 95 is an adsorber, the second separator 7 is a plasma component separator. At this time, the macromolecular substances in the plasma that are larger than the pore size of the plasma component separator membrane are intercepted and enter the adsorption device 95 after passing through the circulation pipeline 9, and the adsorption treatment is carried out repeatedly. The un-intercepted plasma passes through the relay pipeline 8 and enters the input pipeline 3 after the second separator 7. When the adsorption device 95 is a biological device / bioreactor containing cell components, the second separator 7 can be a plasma component separator or a cell filter, etc. At this time, the second separator 7 can separate the plasma from the biological cells and play a role in preventing the biological cell components from entering the body. Part of the plasma or both biological cells carry out material exchange through the hollow fibers or semi-permeable membranes in the second separator 7. This part of the plasma enters the biological device after passing through the circulation pipeline 9, and the biological materials therein can enter the second separator 7 repeatedly through the circulation pipeline 9. Another part of the plasma enters the input pipeline 3 through the relay pipeline 8.

[0102] The blood cells separated by the first separator 5 enter the venous pot 31 through the first output pipe 51. The plasma and blood cells that have completed filtration / adsorption are mixed in the venous pot 31 and then return to the human body 1 through the input pipeline 3.

[0103] During the treatment process, the second separator 7 plays a role of separation or interception, separating the macromolecular toxic substances in the plasma and intercepting the cell components in the adsorption device 95 to prevent them from entering the human body 1.

[0104] In the description of this specification, the descriptions with reference to terms such as "embodiment", "some embodiments", "schematic embodiments", "examples", "specific examples", "some examples", etc. mean that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic expressions of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in a suitable manner in any one or more embodiments or examples.

[0105] The embodiments described in this application are only a part of the embodiments of the present invention, rather than all the embodiments. Those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments. Without conflict, the following embodiments and the features in the embodiments can be combined with each other. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts belong to the scope of protection of the present invention.

Claims

1. An improved multi-purpose pipeline for artificial liver blood purification, characterized in that: It includes: A basic treatment unit, comprising an output pipeline, an input pipeline, a first separator, a plasma pipeline and a fluid infusion port; one end of the first separator is connected to the output pipeline, and the other end is connected to the input pipeline; the side wall of the first separator is connected to the plasma pipeline; one end of the input pipeline is in communication with the fluid infusion port; a fluid infusion valve is provided on the fluid infusion port; and a first discharge port is provided at one end of the plasma pipeline away from the first separator; The first additional unit includes an injection tube, a second separator and a relay pipeline; one end of the second separator is connected to the plasma pipeline through the injection tube, and the other end is connected to the input pipeline through the relay pipeline; The second additional unit includes a side output pipe and a first delivery pipe; one end of the side output pipe is connected to the second separator, and the other end is connected to the input pipeline; one end of the first delivery pipe is connected to the relay pipeline, and the other end is provided with a second discharge port; the inside of the side output pipe is provided with a first side output valve The third additional unit comprises a circulation pipeline; one end of the circulation pipeline is connected to the side output pipe, and the other end of the circulation pipeline is connected to the side wall of the second separator.

2. The improved multi-purpose pipeline for artificial liver blood purification according to claim 1, characterized in that: It also includes a reflux pipeline; one end of the reflux pipeline is connected to the input pipeline, and the other end is connected to the fluid infusion port.

3. The improved multi-purpose pipeline for artificial liver blood purification according to claim 1, characterized in that: The side output pipe is further provided with a second side output valve, a third side output valve and a four-way joint; the four-way joint is connected in series inside the side output pipe and is located between the second side output valve and the third side output valve; the other two interfaces of the four-way joint are connected in series inside the relay pipeline; the first side output valve is located between the second side output valve and the second separator.

4. The improved multi-purpose pipeline for artificial liver blood purification according to claim 3, characterized in that: The connection point between the circulation pipeline and the side output pipe is between the second side output valve and the third side output valve.

5. The improved multi-purpose pipeline for artificial liver blood purification according to claim 1, characterized in that: The side output pipe is connected to the input pipeline through a return slurry pump.

6. The improved multi-purpose pipeline for artificial liver blood purification according to claim 1, characterized in that: The relay pipeline includes a relay pipe body, a second delivery pipe and a third delivery pipe; the side output pipe, the second delivery pipe and the third delivery pipe are connected by a second three-way joint; the end of the second delivery pipe away from the side output pipe is connected to the relay pipe body; one end of the third delivery pipe is connected to the side output pipe, and the other end is connected to the input pipeline; a second delivery valve is provided inside the second delivery pipe; a fourth delivery valve is provided inside the third delivery pipe.

7. The improved multi-purpose pipeline for artificial liver blood purification according to claim 1, characterized in that: A first pump body is arranged inside the output pipeline.

8. The improved multi-purpose pipeline for artificial liver blood purification according to claim 1, characterized in that: A second pump body is arranged inside the plasma pipeline.

9. The improved multi-purpose pipeline for artificial liver blood purification according to claim 1, characterized in that: A third pump body is arranged inside the circulation pipeline.

10. An improved multi-purpose pipeline for artificial liver blood purification according to any one of claims 1 to 9, characterized in that: An adsorption device is arranged inside the circulation pipeline.

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