Sodium hyaluronate composite solution with whitening effect and preparation method thereof

Abstract

The invention relates to the technical field of medical supplies, and discloses a sodium hyaluronate composite solution with a whitening effect, which comprises paeonol, nicotinamide, collagen peptide, macromolecular sodium hyaluronate, micromolecular sodium hyaluronate polydeoxyribonucleotide, sodium chloride, sodium dihydrogen phosphate, disodium hydrogen phosphate, water for injection and a traditional Chinese medicine extract, wherein the proportion amount of the paeonol is 0.5 to 1 part, the proportion amount of the nicotinamide is 0.2 to 0.8 part, the proportion amount of the collagen peptide is 1 to 4 parts, the proportion amount of the macromolecular sodium hyaluronate is 0.05 to 2 parts, and the proportion amount of the micromolecular sodium hyaluronate is 0.05 to 2 parts. According to the sodium hyaluronate composite solution with the whitening effect and the preparation method of the sodium hyaluronate composite solution, the paeonol, the traditional Chinese medicine extract and the nicotinamide are added into the sodium hyaluronate composite solution obtained through the steps, so that the composite solution has a good whitening effect, and meanwhile, traditional Chinese medicines have a relieving effect, so that the absorption speed of a body is increased, and the skin whitening effect is improved. Meanwhile, the preparation steps are simple and convenient.

Description

Technical Field

[0001] The invention relates to the technical field of medical supplies, in particular to a sodium hyaluronate composite solution with whitening effect and a preparation method thereof. Background Art

[0002] Hyaluronic acid, also known as uronic acid and hyaluronic acid, is a glycosaminoglycan composed of D-glucuronic acid and N-acetylglucosamine. It is one of the main components of the extracellular matrix. Hyaluronic acid is different from most glycosaminoglycans. It does not contain sulfur and is formed in the cell membrane rather than in the high-glucose body. Its relative molecular mass can reach 10 orders of magnitude. Its hyaluronic acid molecules can carry more than 500 times the water. It is recognized as the best moisturizing ingredient today and is widely used in skin care products and cosmetics.

[0003] Hyaluronic acid is widely distributed in various parts of the human body, including the skin. The maturation and aging process of human skin also changes with the content and metabolism of hyaluronic acid. It can improve the nutritional metabolism of the skin, make the skin soft and smooth, remove wrinkles, increase elasticity, and prevent aging. While moisturizing, it is also a good transdermal absorption promoter. When used in combination with other nutrients, it can achieve the ideal effect of promoting nutrient absorption.

[0004] However, most of the existing hyaluronic acid only has the function of moisturizing and retaining water. Therefore, in order to make the skin more delicate, smooth and white, it needs to be used in conjunction with other whitening products. This situation increases additional purchase expenses. At the same time, the steps of using multiple products in combination are relatively complicated, which is a waste of time. Therefore, a sodium hyaluronate composite solution with whitening effect is proposed to solve the above problems. Summary of the invention

[0005] 1. Technical issues to be resolved

[0006] In view of the deficiencies in the prior art, the present invention provides a sodium hyaluronate composite solution with whitening effect and a preparation method thereof, which solves the problem that most of the existing hyaluronic acids only have the function of replenishing and retaining water. Therefore, in use, in order to make the skin more delicate, smooth and white, it is necessary to use it in conjunction with other whitening products. This situation increases additional purchase expenses. At the same time, the steps for using multiple products in combination are relatively complicated, which is a waste of time.

[0007] (II) Technical solution

[0008] To achieve the above object, the present invention provides the following technical solutions:

[0009] A sodium hyaluronate composite solution with whitening effect, comprising paeonol, nicotinamide, collagen peptide, macromolecular sodium hyaluronate, micromolecular sodium hyaluronate polydeoxyribonucleotide, sodium chloride, sodium dihydrogen phosphate, sodium hydrogen phosphate, water for injection, and Chinese herbal medicine extract;

[0010] Among them, the proportion of paeonol is 0.5-1 parts, the proportion of niacinamide is 0.2-0.8 parts, the proportion of collagen peptide is 1-4 parts, the proportion of large molecular sodium hyaluronate is 0.05-2 parts, the proportion of small molecular sodium hyaluronate is 0.05-2 parts, the proportion of polydeoxyribonucleotide is 0.02-3 parts, the proportion of sodium chloride is 0.5-1 parts, the proportion of sodium dihydrogen phosphate is 0.01-0.03 parts, the proportion of sodium dihydrogen phosphate is 0.02-0.05 parts, the proportion of water for injection is 100 parts, and the proportion of Chinese herbal medicine extract is 0.2-0.8 parts;

[0011] Among them, the Chinese medicine extract is a mixture of white peony root and angelica root extracts, with a ratio of 1:1.

[0012] A method for preparing a sodium hyaluronate composite solution with whitening effect comprises the following steps:

[0013] Step 1: Select the raw materials: 0.5-1 parts of paeonol, 0.2-0.8 parts of niacinamide, 1-4 parts of collagen peptide, 0.05-2 parts of macromolecular sodium hyaluronate, 0.05-2 parts of small molecule sodium hyaluronate, 0.02-3 parts of polydeoxyribonucleotide, 0.5-1 parts of sodium chloride, 0.01-0.03 parts of sodium dihydrogen phosphate, 0.02-0.05 parts of disodium hydrogen phosphate, 100 parts of water for injection, and 0.2-0.8 parts of Chinese herbal medicine extract;

[0014] Among them, the selected materials are screened to prevent large particles from affecting the subsequent processing effects;

[0015] Step 2: Add sodium chloride, sodium dihydrogen phosphate and disodium hydrogen phosphate to the water for injection in sequence and mix well;

[0016] Then add collagen peptide, macromolecular sodium hyaluronate, micromolecular sodium hyaluronate, and polydeoxyribonucleotide and mix well;

[0017] Secondly, paeonol, niacinamide and Chinese herbal extract were added and mixed evenly to obtain a sodium hyaluronate composite solution;

[0018] Step 3: sterilize the sodium hyaluronate composite solution obtained in the step, and fill it after sterilization to obtain the sodium hyaluronate composite solution with whitening effect.

[0019] Preferably, the sterilization method in step three is ultraviolet sterilization, and the sterilization time is 1-2 hours.

[0020] Preferably, the stirring temperature in step 2 is room temperature, and the stirring time is 10-30 min, 5-10 min, and 10-20 min, respectively.

[0021] Preferably, the stirring device in step 2 is a magnetic stirrer with a rotation speed of 200-500 / min.

[0022] Preferably, in step 2, stirring is performed for 1 minute after each raw material is added during the stirring process.

[0023] Preferably, the Chinese herbal medicine extract can be added or not added according to demand.

[0024] (III) Beneficial effects

[0025] Compared with the prior art, the present invention provides a sodium hyaluronate composite solution with whitening effect and a preparation method thereof, which has the following beneficial effects:

[0026] 1. A method for preparing a sodium hyaluronate composite solution with a whitening effect. The sodium hyaluronate composite solution obtained through the above steps is added with paeonol, a Chinese medicine extract and niacinamide, so that the composite solution has a good whitening effect. At the same time, the Chinese medicine has a soothing effect, thereby promoting the body's absorption rate and improving the functionality of the composite solution. At the same time, the preparation steps are simple and convenient.

[0027] 2. The sodium hyaluronate composite solution with whitening effect, obtained through the above steps, has a whitening effect during use, thus reducing the skin care time and no longer requiring the use of multiple products, thereby reducing the expense of purchasing different products. DETAILED DESCRIPTION

[0028] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0029] A sodium hyaluronate composite solution with whitening effect, comprising paeonol, nicotinamide, collagen peptide, macromolecular sodium hyaluronate, micromolecular sodium hyaluronate polydeoxyribonucleotide, sodium chloride, sodium dihydrogen phosphate, sodium hydrogen phosphate, water for injection, and Chinese herbal medicine extract;

[0030] Among them, the proportion of paeonol is 0.5-1 parts, the proportion of niacinamide is 0.2-0.8 parts, the proportion of collagen peptide is 1-4 parts, the proportion of large molecular sodium hyaluronate is 0.05-2 parts, the proportion of small molecular sodium hyaluronate is 0.05-2 parts, the proportion of polydeoxyribonucleotide is 0.02-3 parts, the proportion of sodium chloride is 0.5-1 parts, the proportion of sodium dihydrogen phosphate is 0.01-0.03 parts, the proportion of sodium dihydrogen phosphate is 0.02-0.05 parts, the proportion of water for injection is 100 parts, and the proportion of Chinese herbal medicine extract is 0.2-0.8 parts;

[0031] Among them, the Chinese medicine extract is a mixture of white peony root and angelica root extracts, with a ratio of 1:1.

[0032] Embodiment 1:

[0033] A method for preparing a sodium hyaluronate composite solution with whitening effect comprises the following steps:

[0034] Step 1: Select the raw materials: 1 part of paeonol, 0.8 part of niacinamide, 4 parts of collagen peptide, 2 parts of macromolecular sodium hyaluronate, 2 parts of small molecule sodium hyaluronate, 3 parts of polydeoxyribonucleotide, 1 part of sodium chloride, 0.03 parts of sodium dihydrogen phosphate, 0.05 parts of disodium hydrogen phosphate, 100 parts of water for injection, and 0.8 parts of Chinese herbal medicine extract;

[0035] Among them, the selected materials are screened to prevent large particles from affecting the subsequent processing effects;

[0036] Step 2: Add sodium chloride, sodium dihydrogen phosphate and disodium hydrogen phosphate to the water for injection in sequence and mix well;

[0037] Then add collagen peptide, macromolecular sodium hyaluronate, micromolecular sodium hyaluronate, and polydeoxyribonucleotide and mix well;

[0038] Secondly, paeonol, niacinamide and Chinese herbal extract were added and mixed evenly to obtain a sodium hyaluronate composite solution;

[0039] Among them, the stirring temperature is room temperature, and the stirring time is 30min, 10min, and 20min respectively;

[0040] Among them, the stirring equipment is magnetic stirring, and the speed is 500 / min;

[0041] In the stirring process, each time a raw material is added, stirring is performed for 1 minute;

[0042] Step 3: sterilizing the sodium hyaluronate composite solution obtained in the step, and filling it after sterilization to obtain the sodium hyaluronate composite solution with whitening effect;

[0043] Among them, the sterilization method described is ultraviolet sterilization, and the sterilization time is 2 hours.

[0044] The sodium hyaluronate composite solution obtained through the above steps has good whitening effect by adding paeonol, Chinese herbal medicine extract and niacinamide. Meanwhile, Chinese herbal medicine has a soothing effect, thereby promoting the body's absorption rate and improving the functionality of the composite solution. Meanwhile, the production steps are simple and convenient.

[0045] Embodiment 2:

[0046] A method for preparing a sodium hyaluronate composite solution with whitening effect comprises the following steps:

[0047] Step 1: Select the raw materials: 0.5 parts of paeonol, 0.2 parts of niacinamide, 1 part of collagen peptide, 0.05 parts of macromolecular sodium hyaluronate, 0.05 parts of small molecule sodium hyaluronate, 0.02 parts of polydeoxyribonucleotide, 0.5 parts of sodium chloride, 0.01 parts of sodium dihydrogen phosphate, 0.02 parts of disodium phosphate, 100 parts of water for injection, and 0.2 parts of Chinese herbal medicine extract;

[0048] Among them, the selected materials are screened to prevent large particles from affecting the subsequent processing effects;

[0049] Step 2: Add sodium chloride, sodium dihydrogen phosphate and disodium hydrogen phosphate to the water for injection in sequence and mix well;

[0050] Then add collagen peptide, macromolecular sodium hyaluronate, micromolecular sodium hyaluronate, and polydeoxyribonucleotide and mix well;

[0051] Secondly, paeonol, niacinamide and Chinese herbal extract were added and mixed evenly to obtain a sodium hyaluronate composite solution;

[0052] Among them, the stirring temperature is room temperature, and the stirring time is 10min, 5min, and 20min respectively;

[0053] Among them, the stirring equipment is magnetic stirring, and the speed is 200 / min;

[0054] In the stirring process, each time a raw material is added, stirring is performed for 1 minute;

[0055] Step 3: sterilizing the sodium hyaluronate composite solution obtained in the step, and filling it after sterilization to obtain the sodium hyaluronate composite solution with whitening effect;

[0056] Among them, the sterilization method described is ultraviolet sterilization, and the sterilization time is 1.5 hours.

[0057] The sodium hyaluronate composite solution obtained through the above steps has good whitening effect by adding paeonol, Chinese herbal medicine extract and niacinamide. Meanwhile, Chinese herbal medicine has a soothing effect, thereby promoting the body's absorption rate and improving the functionality of the composite solution. Meanwhile, the production steps are simple and convenient.

[0058] Embodiment three:

[0059] A method for preparing a sodium hyaluronate composite solution with whitening effect comprises the following steps:

[0060] Step 1: Select the raw materials: 0.75 parts of paeonol, 0.4 parts of niacinamide, 2 parts of collagen peptide, 1 part of macromolecular sodium hyaluronate, 1 part of small molecule sodium hyaluronate, 1.5 parts of polydeoxyribonucleotide, 0.75 parts of sodium chloride, 0.02 parts of sodium dihydrogen phosphate, 0.035 parts of disodium hydrogen phosphate, and 100 parts of water for injection;

[0061] Among them, the selected materials are screened to prevent large particles from affecting the subsequent processing effects;

[0062] Step 2: Add sodium chloride, sodium dihydrogen phosphate and disodium hydrogen phosphate to the water for injection in sequence and mix well;

[0063] Then add collagen peptide, macromolecular sodium hyaluronate, micromolecular sodium hyaluronate, and polydeoxyribonucleotide and mix well;

[0064] Secondly, paeonol and niacinamide were added and mixed evenly to obtain a sodium hyaluronate composite solution;

[0065] Among them, the stirring temperature is room temperature, and the stirring time is 15min, 7min, and 13min respectively;

[0066] Among them, the stirring equipment is magnetic stirring, and the speed is 250 / min;

[0067] In the stirring process, each time a raw material is added, stirring is performed for 1 minute;

[0068] Step 3: sterilizing the sodium hyaluronate composite solution obtained in the step, and filling it after sterilization to obtain the sodium hyaluronate composite solution with whitening effect;

[0069] Among them, the sterilization method described is ultraviolet sterilization, and the sterilization time is 1.5 hours.

[0070] The sodium hyaluronate composite solution obtained through the above steps is added with paeonol, Chinese herbal medicine extract and niacinamide, so that the composite solution has a good whitening effect, improves the functionality of the composite solution, and the preparation steps are simple and convenient.

[0071] Embodiment 4:

[0072] A method for preparing a sodium hyaluronate composite solution with whitening effect comprises the following steps:

[0073] Step 1: Select the raw materials: 1 part of paeonol, 0.8 part of niacinamide, 1 part of collagen peptide, 2 parts of macromolecular sodium hyaluronate, 0.05 parts of small molecule sodium hyaluronate, 0.02 parts of polydeoxyribonucleotide, 0.5 parts of sodium chloride, 0.01 parts of sodium dihydrogen phosphate, 0.02 parts of disodium hydrogen phosphate, 100 parts of water for injection, and 0.2 parts of Chinese herbal medicine extract;

[0074] Among them, the selected materials are screened to prevent large particles from affecting the subsequent processing effects;

[0075] Step 2: Add sodium chloride, sodium dihydrogen phosphate and disodium hydrogen phosphate to the water for injection in sequence and mix well;

[0076] Then add collagen peptide, macromolecular sodium hyaluronate, micromolecular sodium hyaluronate, and polydeoxyribonucleotide and mix well;

[0077] Secondly, paeonol, niacinamide and Chinese herbal extract were added and mixed evenly to obtain a sodium hyaluronate composite solution;

[0078] Among them, the stirring temperature is room temperature, and the stirring time is 25min, 8min, and 25min respectively;

[0079] Among them, the stirring equipment is magnetic stirring, and the speed is 400 / min;

[0080] In the stirring process, each time a raw material is added, stirring is performed for 1 minute;

[0081] Step 3: sterilizing the sodium hyaluronate composite solution obtained in the step, and filling it after sterilization to obtain the sodium hyaluronate composite solution with whitening effect;

[0082] Among them, the sterilization method described is ultraviolet sterilization, and the sterilization time is 1.3 hours.

[0083] The sodium hyaluronate composite solution obtained through the above steps has good whitening effect by adding paeonol, Chinese herbal medicine extract and niacinamide. Meanwhile, Chinese herbal medicine has a soothing effect, thereby promoting the body's absorption rate and improving the functionality of the composite solution. Meanwhile, the production steps are simple and convenient.

[0084] Embodiment five:

[0085] A method for preparing a sodium hyaluronate composite solution with whitening effect comprises the following steps:

[0086] Step 1: Select the raw materials: 0.5 parts of paeonol, 0.2 parts of niacinamide, 1 part of collagen peptide, 0.05 parts of macromolecular sodium hyaluronate, 2 parts of small molecule sodium hyaluronate, 3 parts of polydeoxyribonucleotide, 1 part of sodium chloride, 0.03 parts of sodium dihydrogen phosphate, 0.05 parts of disodium hydrogen phosphate, 100 parts of water for injection, and 0.8 parts of Chinese herbal medicine extract;

[0087] Among them, the selected materials are screened to prevent large particles from affecting the subsequent processing effects;

[0088] Step 2: Add sodium chloride, sodium dihydrogen phosphate and disodium hydrogen phosphate to the water for injection in sequence and mix well;

[0089] Then add collagen peptide, macromolecular sodium hyaluronate, micromolecular sodium hyaluronate, and polydeoxyribonucleotide and mix well;

[0090] Secondly, paeonol, niacinamide and Chinese herbal extract were added and mixed evenly to obtain a sodium hyaluronate composite solution;

[0091] Among them, the stirring temperature is room temperature, and the stirring time is 30min, 10min, and 20min respectively;

[0092] Among them, the stirring equipment is magnetic stirring, and the speed is 450 / min;

[0093] In the stirring process, each time a raw material is added, stirring is performed for 1 minute;

[0094] Step 3: sterilizing the sodium hyaluronate composite solution obtained in the step, and filling it after sterilization to obtain the sodium hyaluronate composite solution with whitening effect;

[0095] Among them, the sterilization method described is ultraviolet sterilization, and the sterilization time is 2 hours.

[0096] The sodium hyaluronate composite solution obtained through the above steps has good whitening effect by adding paeonol, Chinese herbal medicine extract and niacinamide. Meanwhile, Chinese herbal medicine has a soothing effect, thereby promoting the body's absorption rate and improving the functionality of the composite solution. Meanwhile, the production steps are simple and convenient.

[0097] Detection of whitening effect by DPPH analysis:

[0098] Principle of DPPH analysis method: DPPH is a stable free radical. It can exist stably in organic solvents. Its alcohol solution is purple and needs to be stored at low temperature and away from light. It has a single electron, so it can accept an electron or hydrogen ion. It has maximum absorption at a wavelength of 517nm. In the presence of free radical scavengers, the single electron of DPPH is captured and its color becomes lighter. The absorbance value at the wavelength of maximum light absorption decreases, and the degree of decrease is linear. The decrease in absorbance level indicates an increase in antioxidant activity, thereby evaluating the antioxidant capacity of the test sample. This antioxidant capacity is expressed by inhibition rate. The greater the inhibition rate, the stronger the antioxidant activity.

[0099] Embodiment 1 Embodiment 2 Embodiment 3 Embodiment 4 Embodiment 5 Inhibition rate 96％ 98％ 93％ 94％ 95％

[0100] Through the above tests, it is known that the sodium hyaluronate composite solution of the present invention can achieve whitening and anti-aging effects by adding paeonol, niacinamide and Chinese herbal medicine extracts to the raw materials.

[0101] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A sodium hyaluronate composite solution with whitening effect, characterized in that: Including paeonol, niacinamide, collagen peptide, macromolecular sodium hyaluronate, micromolecular sodium hyaluronate polydeoxyribonucleotide, sodium chloride, sodium dihydrogen phosphate, disodium hydrogen phosphate, water for injection, and Chinese herbal medicine extracts; Among them, the proportion of paeonol is 0.5-1 parts, the proportion of niacinamide is 0.2-0.8 parts, the proportion of collagen peptide is 1-4 parts, the proportion of large molecular sodium hyaluronate is 0.05-2 parts, the proportion of small molecular sodium hyaluronate is 0.05-2 parts, the proportion of polydeoxyribonucleotide is 0.02-3 parts, the proportion of sodium chloride is 0.5-1 parts, the proportion of sodium dihydrogen phosphate is 0.01-0.03 parts, the proportion of sodium dihydrogen phosphate is 0.02-0.05 parts, the proportion of water for injection is 100 parts, and the proportion of Chinese herbal medicine extract is 0.2-0.8 parts; Among them, the Chinese medicine extract is a mixture of white peony root and angelica root extracts, with a ratio of 1:

1.

2. A method for preparing a sodium hyaluronate composite solution with whitening effect according to claim 1, characterized in that: The following steps are involved: Step 1: Select the raw materials: 0.5-1 parts of paeonol, 0.2-0.8 parts of niacinamide, 1-4 parts of collagen peptide, 0.05-2 parts of macromolecular sodium hyaluronate, 0.05-2 parts of small molecule sodium hyaluronate, 0.02-3 parts of polydeoxyribonucleotide, 0.5-1 parts of sodium chloride, 0.01-0.03 parts of sodium dihydrogen phosphate, 0.02-0.05 parts of disodium hydrogen phosphate, 100 parts of water for injection, and 0.2-0.8 parts of Chinese herbal medicine extract; Step 2: Add sodium chloride, sodium dihydrogen phosphate and disodium hydrogen phosphate to the water for injection in sequence and mix well; Then add collagen peptide, macromolecular sodium hyaluronate, micromolecular sodium hyaluronate, and polydeoxyribonucleotide and mix well; Secondly, paeonol, niacinamide and Chinese herbal extract were added and mixed evenly to obtain a sodium hyaluronate composite solution; Step 3: sterilize the sodium hyaluronate composite solution obtained in the step, and fill it after sterilization to obtain the sodium hyaluronate composite solution with whitening effect.

3. The method for preparing a sodium hyaluronate composite solution with whitening effect according to claim 2, characterized in that: The sterilization method described in step 3 is ultraviolet sterilization, and the sterilization time is 1-2 hours.

4. The method for preparing a sodium hyaluronate composite solution with whitening effect according to claim 2, characterized in that: The stirring temperature in step 2 is room temperature, and the stirring time is 10-30 min, 5-10 min, and 10-20 min respectively.

5. The method for preparing a sodium hyaluronate composite solution with whitening effect according to claim 2, characterized in that: The stirring device in step 2 is a magnetic stirring device with a rotation speed of 200-500 / min.

6. The method for preparing a sodium hyaluronate composite solution with whitening effect according to claim 2, characterized in that: In step 2, stir for 1 minute after adding each raw material during the stirring process.

7. The method for preparing a sodium hyaluronate composite solution with whitening effect according to claim 2, characterized in that: The selected material is screened as described in step 1.

8. The method for preparing a sodium hyaluronate composite solution with whitening effect according to claim 2, characterized in that: The Chinese herbal medicine extract can be added or not added according to demand.