Collision reaction tank based on printed circuit board

Abstract

The invention provides a collision reaction tank based on a printed circuit board, the collision reaction tank comprises a main tank body, an inlet electrode, an outlet electrode, a front base, a rear base and the printed circuit board, the printed circuit board is fixedly connected with the main tank body through a structural member, the front base and the rear base are installed on the main tank body through sealing rings, and the inlet electrode is connected with the outlet electrode. The front base and the rear base are used for installing an inlet electrode and an outlet electrode, copper is laid on the surface of the printed circuit board in a segmented mode, and gradient direct-current voltage bias is applied to the surface of the printed circuit board so that the axial electric field function can be achieved. According to the invention, good ion transmission efficiency can be ensured, and quality screening of a certain degree can be realized.

Description

Technical Field

[0001] The invention relates to the technical field of mass spectrometers, and in particular to a collision reaction cell based on a printed circuit board. Background Art

[0002] Inductively coupled plasma quadrupole mass spectrometer (ICP-QMS) is susceptible to interference from polyatomic ions, isobaric ions, and doubly charged ions during the analysis process. The introduction of collision reaction cell technology has significantly improved the detection limit and chemical resolution of ICP-QMS, and expanded its application in trace / ultra-trace multi-element analysis, isotope ratio analysis, morphological analysis and other fields.

[0003] In some types of tandem mass spectrometry, after obtaining a strong quasi-molecular ion peak of the analyte under the conditions of primary mass spectrometry (MS), it is necessary to perform collision fragmentation on the quasi-molecular ions, and obtain more abundant compound fragment information by tandem mass spectrometry (MS / MS) to determine the compound structure and achieve quantitative analysis of the target compound. Therefore, the collision reaction cell is also the core ion optical component of tandem mass spectrometry.

[0004] At present, the main structure of the collision reaction cell for ion transmission generally adopts a multipole form, including quadrupoles, hexapole, octopole and other types. By tilting the poles and adding special-shaped rods, an axial electric field is established to ensure the axial ion kinetic energy so that the ions of interest can pass through the collision reaction cell smoothly. This structural form is difficult to assemble and has high R&D and production costs. Summary of the invention

[0005] In view of this, the problem to be solved by the present invention is to provide a collision reaction cell based on a printed circuit board.

[0006] In order to solve the above technical problems, the technical solution adopted by the present invention is: a collision reaction cell based on a printed circuit board, comprising a main cell body, an inlet electrode, an outlet electrode, a front base, a rear base and a printed circuit board, wherein the printed circuit board is fixedly connected to the main cell body through a structural member, the front base and the rear base are installed with the main cell body through a sealing ring, the front base and the rear base are used to install the inlet electrode and the outlet electrode, and the surface of the printed circuit board is paved with copper in sections and a gradient DC voltage bias is applied to realize an axial electric field function.

[0007] In the present invention, preferably, the inlet electrode and the outlet electrode are configured as stainless steel circular sheets or rectangular sheets with through holes.

[0008] In the present invention, preferably, the aperture size of the via hole is set to 1 mm-3 mm, and the hole thickness is set to 0.3 mm-0.6 mm.

[0009] In the present invention, preferably, the front base and the rear base are made of ceramic, polycarbonate or polyetheretherketone.

[0010] In the present invention, preferably, the main pool body is configured as a cylindrical or rectangular hollow structure, and the material of the main pool body is alumina ceramics, aluminum alloy or stainless steel.

[0011] In the present invention, preferably, the sealing ring is configured as a rubber ring or a tetrafluoroethylene ring.

[0012] In the present invention, preferably, the structural member is made of polyetheretherketone or polyimide.

[0013] In the present invention, preferably, the main cell body is provided with a gas connection hole, and the gas connection hole is used to introduce collision gas or reaction gas, and the collision gas or reaction gas is one or more of helium, methane, ammonia, nitrogen, oxygen or argon.

[0014] In the present invention, preferably, both the front and rear sides of the printed circuit board are provided with electronic connectors for power feeding, and the electronic connectors adopt a spring pin structure or a screw structure. The electronic connectors adopt a DC voltage bias setting with a certain frequency change, so as to constrain the ions in the main cell body to reciprocate inside the main cell body.

[0015] The advantages and positive effects of the present invention are as follows: the semi-enclosed cell body is formed by the inlet electrode, the outlet electrode, the front base, the rear base and the main cell body, the printed circuit boards are arranged in a certain orientation to form an ion transmission component, a mechanical connection structure and an electronic connection part, and four groups of printed circuit boards form a quadrupole electric field coupled with a high-order multipole field, which can not only ensure good ion transmission efficiency, but also achieve a certain degree of quality screening. The surface of the printed circuit board is copper-plated in sections, and a gradient DC voltage bias is applied to realize the axial electric field function. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. In the accompanying drawings:

[0017] Figure 1 It is an overall structural diagram of a collision reaction cell based on a printed circuit board of the present invention;

[0018] Figure 2 It is a circuit connection schematic diagram of a collision reaction cell based on a printed circuit board of the present invention;

[0019] Figure 3a It is a schematic diagram of the first copper plating potential distribution of a collision reaction cell based on a printed circuit board of the present invention;

[0020] Figure 3b It is a schematic diagram of the second copper plating potential distribution of a collision reaction cell based on a printed circuit board of the present invention;

[0021] In the figure: 1. inlet electrode; 2. outlet electrode; 3. front base; 4. rear base; 5. main cell body; 6. structural parts; 7. printed circuit board; 8. sealing ring; 9. connecting part; 10. connecting hole. DETAILED DESCRIPTION

[0022] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0023] It should be noted that when a component is referred to as being "fixed to" another component, it may be directly on the other component or there may also be a component centered. When a component is considered to be "connected to" another component, it may be directly connected to the other component or there may also be a component centered. When a component is considered to be "set on" another component, it may be directly set on the other component or there may also be a component centered. The terms "vertical", "horizontal", "left", "right" and similar expressions used herein are for illustrative purposes only.

[0024] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art of the present invention. The terms used herein in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention. The term "and / or" used herein includes any and all combinations of one or more related listed items.

[0025] like Figure 1As shown, the present invention provides a collision reaction cell based on a printed circuit board 7, comprising a main cell body 5, an inlet electrode 1, an outlet electrode 2, a front base 3, a rear base 4 and a printed circuit board 7, wherein the printed circuit board 7 is fixedly connected to the main cell body 5 through a structural member 6, the front base 3 and the rear base 4 are installed with the main cell body 5 through a sealing ring 8, the front base 3 and the rear base 4 are used to install the inlet electrode 1 and the outlet electrode 2, and the surface of the printed circuit board 7 is paved with copper in sections and a gradient DC voltage bias is applied to realize the axial electric field function. Among them, the inlet electrode 1, the outlet electrode 2, the front base 3, the rear base 4 and the main cell body 5 together form a semi-enclosed cell body. In this embodiment, the printed circuit board 7 is set to four groups, and the four groups of printed circuit boards 7 are arranged in a certain orientation to form an ion transmission component, a mechanical connection structure and an electronic connection member 9. The four groups of printed circuit boards 7 constitute a quadrupole electric field coupled with a high-order multipolar field, which can not only ensure good ion transmission efficiency, but also achieve a certain degree of quality screening. The surface of the printed circuit board 7 is copper-plated in sections, and a gradient DC voltage bias is applied to achieve an axial electric field function.

[0026] A printed circuit board 7 is used as an effective electrode. The circuit board is rectangular in shape, and the four groups of circuit boards are evenly arranged in the upper, lower, left and right directions. The relative spacing between the circuit boards is based on the principle of quadrupole electric field and quadrupole ion transmission, and depends on the preset mass range, AC voltage operating frequency, voltage amplitude and other parameters. On the inner side of the printed circuit board 7 electrode, copper is laid according to a certain rule. After applying an AC voltage, an alternating electric field can be formed in the area surrounding the four groups of circuit boards, which is similar to a quadrupole electric field and couples high-order multipolar field components. By adopting multi-stage copper laying and applying a DC voltage bias with a certain gradient respectively, an electric potential gradient can be formed in the axial direction of the area surrounding the circuit board, that is, an axial electric field. On the outside of the circuit board, that is, the back side of the copper-plated side, a DC / AC distribution circuit composed of a group of resistors and capacitors is used to realize the coupling and gradient application of AC voltage and DC voltage, respectively, such as Figure 2 shown.

[0027] The copper plating width and spacing of the printed circuit board 7 can be adjusted according to the actual required potential gradient. Figure 3a and 3b Two different copper width settings are shown in Figure 1, and the corresponding potential curves on the axis line. Similarly, the resistance value of the voltage divider resistor on the back of the circuit board can also be adjusted to obtain a special potential distribution curve.

[0028] The combination form of the printed circuit board 7 is not limited to four groups of uniform arrangement, and can be a combination form of six groups, eight groups, twelve groups, etc., which can be quickly designed and tested according to the potential well width requirements and experimental purposes. Multipole components such as quadrupoles, hexapole rods, octopole rods, etc. can be installed before and after the electrodes of the printed circuit board 7 for ion guidance and focusing transmission, reducing the influence of the fringe electric field and improving the matching degree of the front and rear ion optical components.

[0029] The installation form of the printed circuit board 7 is not limited to the installation structure described in this patent, and can also be a form of front and rear side assembly of the polyetheretherketone structural member 6, and a groove arrangement for the circuit board for assembly.

[0030] In this embodiment, further, the inlet electrode 1 and the outlet electrode 2 are configured as stainless steel circular sheets or rectangular sheets with through holes, and the diameter of the circular holes is adjusted according to the gas pressure and vacuum environment of the collision cell.

[0031] In this embodiment, further, the aperture size of the via hole is set to 1 mm-3 mm, and the hole thickness is set to 0.3 mm-0.6 mm.

[0032] In this embodiment, further, the front base 3 and the rear base 4 are made of ceramic, polycarbonate or polyetheretherketone, and the front base 3 and the rear base 4 are used to install the inlet electrode 1 and the outlet electrode 2, as well as the installation and positioning of the collision reaction cell assembly in the mass spectrometry ion optical system.

[0033] In this embodiment, further, the main pool body 5 is configured as a cylindrical or rectangular hollow structure, and the material of the main pool body 5 is alumina ceramics, aluminum alloy or stainless steel.

[0034] In this embodiment, further, the sealing ring 8 is configured as a rubber ring or a tetrafluoroethylene ring.

[0035] In this embodiment, further, the structural member 6 is made of polyetheretherketone or polyimide.

[0036] In this embodiment, further, the main cell body 5 is provided with a gas connection hole 10, and the gas connection hole 10 is used to introduce collision gas or reaction gas, and the collision gas or reaction gas is one or more of helium, methane, ammonia, nitrogen, oxygen or argon.

[0037] In this embodiment, further, both the front and rear sides of the printed circuit board 7 are provided with electronic connectors 9 for power feeding, and the electronic connectors 9 adopt a spring pin structure or a screw structure. The electronic connectors 9 adopt a DC voltage bias setting with a certain frequency change, so as to constrain the ions in the main cell body 5 to reciprocate inside the main cell body 5.

[0038] There are electronic connectors 9 for power supply on the front and back sides of the printed circuit board 7. A DC voltage bias setting with a certain frequency change can be used to confine ions to the inside of the cell body for reciprocating motion. The purpose of improving the working efficiency of the collision reaction cell is achieved by extending the ion movement path and increasing the probability of ion-molecule collision, and the working mode of the collision reaction cell can be further extended.

[0039] The functions that this collision reaction cell can achieve include but are not limited to:

[0040] 1. No gas is introduced, only AC and DC bias is applied, and it is used as an ion guide transmission device;

[0041] 2. Introduce helium, hydrogen or nitrogen, set a smaller initial kinetic energy of the ions, and achieve ion beam cooling and focusing;

[0042] 3. Helium or hydrogen is introduced, and the voltage threshold, i.e., the kinetic energy threshold for ions to pass through, is set at the outlet electrode 2. After the ion molecules collide, only ions with kinetic energy exceeding the threshold can pass through the collision cell, thus achieving the effect of polyatomic ion removal;

[0043] 4. Introduce gases such as hydrogen, oxygen, methane, and ammonia, set a smaller initial kinetic energy of the ions and a reasonable axial electric field, and remove interfering ions by reacting the interfering ions or the ions to be measured with the active gas molecules;

[0044] 5. Introduce nitrogen, argon and other gases, set a larger initial kinetic energy of the ions, achieve ion collision dissociation, and obtain ion fragmentation information.

[0045] The embodiments of the present invention are described in detail above, but the contents described are only preferred embodiments of the present invention and cannot be considered to limit the scope of implementation of the present invention. All equivalent changes and improvements made within the scope of the present invention should still fall within the scope of this patent.

Claims

1. A collision reaction cell based on a printed circuit board, characterized in that: The collision reaction cell comprises a main cell body, an inlet electrode, an outlet electrode, a front base, a rear base and a printed circuit board. The printed circuit board is fixedly connected to the main cell body through a structural member. The front base and the rear base are installed with the main cell body through a sealing ring. The front base and the rear base are used to install the inlet electrode and the outlet electrode. Copper is laid in sections on the surface of the printed circuit board and a gradient DC voltage bias is applied to realize an axial electric field function.

2. A collision reaction cell based on a printed circuit board according to claim 1, characterized in that: The inlet electrode and the outlet electrode are configured as stainless steel circular sheets or rectangular sheets with through holes.

3. A collision reaction cell based on a printed circuit board according to claim 2, characterized in that: The aperture size of the via hole is set to 1mm-3mm, and the hole thickness is set to 0.3mm-0.6mm.

4. A collision reaction cell based on a printed circuit board according to claim 1, characterized in that: The front base and the rear base are made of ceramic, polycarbonate or polyetheretherketone.

5. A collision reaction cell based on a printed circuit board according to claim 1, characterized in that: The main pool body is configured as a cylindrical or rectangular hollow structure, and the material of the main pool body is alumina ceramics, aluminum alloy or stainless steel.

6. A collision reaction cell based on a printed circuit board according to claim 1, characterized in that: The sealing ring is configured as a rubber ring or a tetrafluoroethylene ring.

7. A collision reaction cell based on a printed circuit board according to claim 1, characterized in that: The structural member is made of polyetheretherketone or polyimide.

8. A collision reaction cell based on a printed circuit board according to claim 1, characterized in that: The main cell body is provided with a gas connection hole, and the gas connection hole is used to introduce collision gas or reaction gas. The collision gas or reaction gas is one or more of helium, methane, ammonia, nitrogen, oxygen or argon.

9. A collision reaction cell based on a printed circuit board according to claim 1, characterized in that: The front and rear sides of the printed circuit board are both provided with electronic connectors for power feeding, and the electronic connectors adopt a spring pin structure or a screw structure. The electronic connectors adopt a DC voltage bias setting with a certain frequency change, which is used to constrain the ions in the main cell body to reciprocate inside the main cell body.

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