A traditional Chinese medicine formula for treating the syndrome of exogenous cold complicated with endogenous heat of respiratory virus infection

Abstract

The present invention belongs to the technical field of traditional Chinese medicine, and discloses a traditional Chinese medicine formula for treating the syndrome of external cold with internal heat due to respiratory virus infection. The formula is composed of the following raw materials in parts by weight: 20-40 parts of gypsum fibrosum, 10-20 parts of mentha haplocalyx, 10-20 parts of cryptotympana pustulata fabricius, 5-15 parts of glycyrrhiza uralensis, 10-20 parts of scutellaria baicalensis, 5-15 parts of coptis chinensis, 10-20 parts of forsythia suspensa, 10-20 parts of lonicera japonica, 5-15 parts of platycodon grandiflorum; the traditional Chinese medicine formula is made into granule drugs in advance through the steps of decocting - concentrating - drying - powdering, and configured into bags; the application of the traditional Chinese medicine formula in the preparation of treating, preventing or prognosticating the syndrome of external cold with internal heat due to respiratory virus infection with partial heat-toxicity; using the traditional Chinese medicine formula to treat patients with the syndrome of external cold with internal heat due to respiratory virus infection in the early stage with partial heat-toxicity can effectively relieve related symptoms, and at the same time improve the prognosis of the disease, and can effectively avoid the aggravation of the condition.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and particularly to a traditional Chinese medicine for treating the syndrome of external cold and internal heat caused by respiratory virus infection. Background Art

[0002] Since the 1970s, the World Health Organization has monitored and found that new infectious diseases have emerged almost every year globally, and viral diseases are the main types. The respiratory tract is the most common site of viral invasion. Statistics show that 70%-80% of the pathogenic microorganisms causing upper respiratory tract infections are viruses, and about 61% of the lower respiratory tract are viruses.

[0003] For respiratory virus infections, early recognition, early intervention, and blocking the transmission and transformation are the keys to reducing severe cases and mortality. Common RNA viruses such as influenza virus, respiratory syncytial virus, and coronavirus, due to their structural characteristics, will conceal the recognizable RNA replicators produced by themselves after infecting the host, resulting in immune escape, and then causing a large amount of virus replication and aggravating the infection. Therefore, in the early stage of infection, how to accurately identify the key links of the disease outcome and timely carry out treatment intervention to avoid the aggravation of the disease is the focus of preventing and treating severe cases of respiratory virus infection. At present, clinical practice lacks sufficient attention to the early stage of respiratory virus infection, and there are no biomarkers or clinical evaluation techniques related to the severity of respiratory virus infection. At the same time, the treatment of the early stage of respiratory virus infection is mainly conventional treatment, which usually cannot effectively relieve the clinical symptoms of patients.

[0004] Traditional Chinese medicine believes that respiratory virus infection belongs to the categories of "pestilence", "exogenous febrile disease", etc. For the early stage of respiratory virus infection, the relevant diagnosis and treatment plans of traditional Chinese medicine include syndromes such as wind-cold, wind-heat, summer-dampness, qi deficiency, and yang deficiency. In addition to the above common syndromes, the syndrome of external cold and internal heat is also a common syndrome of respiratory virus infection, especially more common in the high-incidence season of influenza in winter and spring. This is the deficiency of the current diagnosis and treatment plans related to respiratory virus infection. Professor Qi Wensheng of the Emergency Department of Guang'anmen Hospital, based on decades of clinical observations and data statistics, believes that the syndrome of external cold and internal heat objectively exists in respiratory virus infection, and proposes that the syndrome of external cold and internal heat is a specific syndrome that can form typical viral pneumonia or lead to the aggravation of the disease in the early stage of respiratory virus infection. He also further found that patients with the syndrome of external cold and internal heat can be divided into those with relatively more external cold and those with relatively more heat-toxin according to their constitutions and disease course stages, and for the first time proposed the treatment plan of "using Chaige Qingsan Decoction for those with mainly external cold and Jiedu Qingwen Decoction for those with mainly heat-toxin", and confirmed its definite effectiveness and safety through clinical observations. Summary of the Invention

[0005] The present invention aims to provide a traditional Chinese medicine for treating the syndrome of external cold and internal heat caused by respiratory virus infection. Using this traditional Chinese medicine to treat patients with the syndrome of mainly heat-toxin in the early stage of respiratory virus infection with the syndrome of external cold and internal heat can effectively relieve related symptoms, improve the prognosis of the disease, and effectively avoid the aggravation of the condition.

[0006] To achieve the above object, the present invention provides the following technical solutions:

[0007] A traditional Chinese medicine for treating the syndrome of external cold and internal heat caused by respiratory virus infection, wherein the traditional Chinese medicine is composed of the following raw materials in parts by weight:

[0008] 20-40 parts of gypsum fibrosum, 10-20 parts of mentha haplocalyx, 10-20 parts of cryptotympana pustulata, 5-15 parts of glycyrrhiza uralensis, 10-20 parts of scutellaria baicalensis, 5-15 parts of coptis chinensis, 10-20 parts of forsythia suspensa, 10-20 parts of lonicera japonica, 5-15 parts of platycodon grandiflorum.

[0009] Further, the traditional Chinese medicine is composed of the following raw materials in parts by weight:

[0010] 30 parts of gypsum fibrosum, 12 parts of mentha haplocalyx, 15 parts of cryptotympana pustulata, 10 parts of glycyrrhiza uralensis, 15 parts of scutellaria baicalensis, 10 parts of coptis chinensis, 15 parts of forsythia suspensa, 15 parts of lonicera japonica, 10 parts of platycodon grandiflorum.

[0011] The preparation method of the above traditional Chinese medicine for treating the syndrome of external cold and internal heat caused by respiratory virus infection comprises the following steps:

[0012] S1. Preparation of raw materials

[0013] Selection and cleaning: First, select the raw materials, remove the impurities, non-medicinal parts, damaged and deteriorated raw materials; then clean the raw materials to remove the dust and soil on the surface;

[0014] Cutting and pulverizing: Cut or pulverize the raw materials according to the characteristics and requirements of the raw materials;

[0015] S2. Decoction

[0016] Soaking: Put the raw materials prepared in step S1 into a container, add clear water and soak for 30-60 min to make the raw materials fully absorb water and expand;

[0017] Decoction: Put the soaked raw materials and water into a decocting pot, heat to boiling and then turn to low heat to continue decocting; and control the decocting time and heat according to the nature and efficacy requirements of the medicinal materials;

[0018] Combining decoction liquid: Combine the decoction liquids obtained from multiple decoctions to form a decoction liquid;

[0019] S3. Concentration

[0020] Filtration: Filter the combined decoction liquid to remove the impurities and suspended matters therein;

[0021] Concentration: Concentrate the filtered decoction liquid and remove the excess water by heating and evaporation;

[0022] S4. Drying

[0023] Adopt spray drying or vacuum drying to remove the moisture in the liquid medicine while maintaining the active ingredients and efficacy of the liquid medicine;

[0024] S5. Preparation and packaging

[0025] Mix various traditional Chinese medicine powders together according to the mass ratio of the raw materials to prepare an oral dosage form, and package it to obtain the required traditional Chinese medicine.

[0026] Furthermore, in step S5, the prepared oral dosage form is one of granules, oral liquid, powder, tablets, capsules, pills.

[0027] Furthermore, the prepared oral dosage form is granules and is packaged in bags.

[0028] The application of the above traditional Chinese medicine for treating the syndrome of external cold and internal heat due to respiratory virus infection in the preparation of drugs for treating the syndrome of external cold and internal heat due to respiratory virus infection with partial heat toxin.

[0029] The principle and beneficial effects of the technical solution are as follows:

[0030] Gypsum Fibrosum: sweet, pungent, extremely cold; functions and indications: clearing heat and purging fire, removing vexation and quenching thirst. Used for exogenous febrile diseases, high fever with vexation and thirst, cough and asthma due to lung heat, excessive fire of stomach meridian, headache, toothache.

[0031] Mentha haplocalyx Briq.: pungent, cool; functions and indications: dispersing wind-heat, clearing the head and eyes, and promoting eruption. Used for wind-heat cold, initial stage of wind-warm disease, headache, red eyes, sore throat, aphtha, rubella, measles, stuffiness and fullness in the chest and hypochondrium.

[0032] Periostracum Cicadae: sweet, cold; functions and indications: dispersing wind and clearing heat, relieving sore throat, promoting eruption, removing nebula, and relieving spasm. Used for wind-heat cold, sore throat, hoarseness, measles not erupting, rubella itching, red eyes with nebula, infantile convulsion, tetanus.

[0033] Radix Glycyrrhizae: sweet, neutral; functions and indications: invigorating the spleen and replenishing qi, clearing heat and detoxifying, resolving phlegm and relieving cough, relieving spasm and pain, and harmonizing various medicines. Used for weakness of the spleen and stomach, lassitude and weakness, palpitation and shortness of breath, cough with copious phlegm, abdominal pain and pain in the extremities, carbuncle and sore, and relieving the toxicity and potency of drugs.

[0034] Radix Scutellariae: bitter, cold; functions and indications: clearing heat and drying dampness, purging fire and detoxifying, stopping bleeding, and preventing miscarriage. Used for damp-warm disease, summer-heat dampness syndrome with chest distress and nausea, damp-heat obstruction, diarrhea, dysentery, jaundice, cough due to lung heat, high fever with vexation and thirst, hematemesis and epistaxis due to blood heat, carbuncle and sore, and threatened abortion.

[0035] Rhizoma Coptidis: bitter, cold; functions and indications: clearing heat and drying dampness, purging fire and detoxifying. Used for damp-heat obstruction, vomiting and acid regurgitation, diarrhea, dysentery, jaundice, high fever and coma, hyperactivity of heart fire, restlessness and insomnia, hematemesis and epistaxis due to blood heat, red eyes, toothache, polydipsia, carbuncle and furuncle; externally used for eczema, wet sore, and purulent ear canal.

[0036] Forsythia suspensa: Bitter, slightly cold; Function and indications: Clearing heat and detoxifying, dissipating swelling and nodules. For carbuncles, scrofula, breast abscess, erysipelas, wind-heat cold, the initial stage of warm diseases, heat invading nutrient-blood, high fever with restlessness and thirst, coma with maculae, heat strangury with dysuria.

[0037] Honeysuckle flower: Sweet, cold; Function and indications: Clearing heat and detoxifying, dispersing wind-heat. For carbuncles and boils, sore throat, erysipelas, dysentery due to heat-toxin, wind-heat cold, fever in warm diseases.

[0038] Platycodon grandiflorum: Bitter, pungent, flat; Function and indications: Promoting lung qi dispersing, relieving sore throat, resolving phlegm, discharging pus. For profuse phlegm with cough, chest distress, sore throat, hoarseness, lung abscess with expectoration of pus, non-ulceration of abscess with pus formation.

[0039] The traditional Chinese medicine provided by the present invention is mainly used for treating the early stage of exogenous cold enveloping heat syndrome with heat-toxin as the main manifestation, and the clinical manifestations are mainly high fever, sore throat, cough with yellow sticky phlegm, dry mouth, flushed face, yellow urine, sticky or dry stools and other symptoms.

[0040] This traditional Chinese medicine is used to treat the early stage of cold enveloping heat syndrome with heat-toxin preponderance in respiratory virus infection, which can effectively relieve related symptoms, improve the prognosis of the disease, and avoid further damage to the patient's health and increase in treatment costs caused by the aggravation of the condition; moreover, this traditional Chinese medicine is easy to use and has a wide range of applicable populations, and can be widely promoted and applied in clinical practice. Detailed implementation mode

[0041] The present invention will be further described in detail below in conjunction with embodiments:

[0042] A traditional Chinese medicine for treating cold enveloping heat syndrome in respiratory virus infection, which is composed of the following raw materials in parts by weight:

[0043] Gypsum fibrosum 20 - 40 parts, Mentha haplocalyx Briq. 10 - 20 parts, Cryptotympana pustulata Fabricius 10 - 20 parts, Glycyrrhiza uralensis Fisch. 5 - 15 parts, Scutellaria baicalensis Georgi 10 - 20 parts, Coptis chinensis Franch. 5 - 15 parts, Forsythia suspensa 10 - 20 parts, Honeysuckle flower 10 - 20 parts, Platycodon grandiflorum 5 - 15 parts.

[0044] Further, the traditional Chinese medicine is composed of the following raw materials in parts by weight:

[0045] Gypsum fibrosum 30 parts, Mentha haplocalyx Briq. 12 parts, Cryptotympana pustulata Fabricius 15 parts, Glycyrrhiza uralensis Fisch. 10 parts, Scutellaria baicalensis Georgi 15 parts, Coptis chinensis Franch. 10 parts, Forsythia suspensa 15 parts, Honeysuckle flower 15 parts, Platycodon grandiflorum 10 parts.

[0046] The preparation method of the above-mentioned traditional Chinese medicine for treating cold enveloping heat syndrome in respiratory virus infection includes the following steps:

[0047] S1. Preparation of raw materials

[0048] Selection and cleaning: First, select the raw materials, remove the impurities, non-medicinal parts, damaged and deteriorated raw materials; then clean the raw materials to remove the dust and soil on the surface;

[0049] Cutting and crushing: Cut or crush the API according to the characteristics and requirements of the API.

[0050] S2. Decoction

[0051] Soaking: Put the API prepared in step S1 into a container, add clear water and soak for 30 - 60 minutes to make the API fully absorb water and swell.

[0052] Decoction: Put the soaked API and water together into a decocting pot, heat to boiling and then turn to low heat to continue decocting; and control the decocting time and heat according to the nature of the medicinal materials and the requirements of the medicinal effect.

[0053] Combining the decocted liquid: Combine the decocted liquids obtained from multiple decoctions to form a decocted liquid.

[0054] S3. Concentration

[0055] Filtration: Filter the combined decocted liquid to remove impurities and suspended matters therein.

[0056] Concentration: Concentrate the filtered decocted liquid and remove the excess water by heating and evaporation.

[0057] S4. Drying

[0058] Adopt spray drying or vacuum drying to remove the water in the liquid medicine while maintaining the active ingredients and medicinal effects of the liquid medicine.

[0059] S5. Preparation and packaging

[0060] Mix various traditional Chinese medicine powders together according to the mass ratio of the API to prepare an oral dosage form, and package it, which is the required traditional Chinese medicine.

[0061] Furthermore, the prepared oral dosage form is one of granules, oral liquid, powder, tablets, capsules, pills.

[0062] Furthermore, the prepared oral dosage form is granules and is packaged in bags.

[0063] Application of the above traditional Chinese medicine for treating cold - enveloped - fire syndrome of respiratory virus infection in the preparation of drugs for cold - enveloped - fire syndrome of respiratory virus infection with relatively more heat - toxin. Examples

[0064] Take 30 g of gypsum fibrosum, 12 g of mentha haplocalyx, 15 g of cicada slough, 10 g of glycyrrhiza uralensis, 15 g of scutellaria baicalensis, 10 g of coptis chinensis, 15 g of forsythia suspensa, 15 g of lonicera japonica, 10 g of platycodon grandiflorum, prepare granule drugs through the steps of decoction - concentration - drying - powder making, package in bags, add a small amount of warm water when taking for those with cold - enveloped - fire syndrome with relatively more heat - toxin, generally twice a day, and those with severe conditions can take four times a day for a short period. Examples

[0065] Xu XX, male, 24 years old. First diagnosis: low fever accompanied by sore throat for 1 day. One day ago, the patient had fever without obvious cause, Tmax: 37.9°C, accompanied by sore throat, cough and expectoration, with a small amount of yellow sticky sputum. The test for influenza A was positive, and the blood routine was normal. Current symptoms: fever, T: 37.7°C, sore throat like being cut by a knife, slightly afraid of cold, accompanied by cough and expectoration, with a small amount of sputum, headache, occasional chest tightness and shortness of breath, normal appetite and sleep, normal bowel movement, yellow urine. The clinical symptom score was 13 points, and 5 doses of the traditional Chinese medicine formula of the present invention were given. At the second diagnosis, the patient had no fever, the sore throat was relieved, the cough was relieved, and the clinical symptom score was 3 points. Example

[0066] Wang XX, male, 23 years old. First diagnosis: fever accompanied by cough and sore throat for 1 day. One day ago, the patient had fever without obvious cause, self-tested positive for influenza A antigen, T: 38.2°C, cough, no expectoration, accompanied by sore throat, a feeling of foreign body in the throat, bad breath, flushed face, with acne, occasional headache, normal appetite and sleep, dry stool, yellow urine, and the clinical symptom score was 10 points. 5 doses of the traditional Chinese medicine formula of the present invention were given. The patient's fever subsided, the cough and sore throat were relieved, and the acne decreased, and the clinical symptom score was 5 points. Example

[0067] Xiao X, female, 26 years old. First diagnosis: fever accompanied by cough for 2 days. Two days ago, the patient had fever without obvious cause, T: 38.5°C, cough, expectoration of yellow sticky sputum, accompanied by dry throat and sore throat. The test for influenza A was positive, blood routine LYM: 0.82×109 / L, CRP: 37mg / L, and other tests were normal, considering influenza A virus infection. Current symptoms: fever, T: 38.2°C, cough, expectoration of yellow sticky sputum, accompanied by dry throat and sore throat, not afraid of cold, sweating little, flushed face, occasional headache, normal appetite and sleep, dry stool, yellow urine, and the clinical symptom score was 10 points. 5 doses of the traditional Chinese medicine formula of the present invention were given. At the second diagnosis, the patient occasionally had fever, T: 37.5°C, the cough and sore throat were relieved, and the clinical symptom score was 6 points. Example

[0068] Long X, male, 32 years old. First diagnosis: fever for 2 days. Two days ago, the patient had fever without obvious cause, T: 38.8°C, accompanied by fear of cold, sweating little. After taking Ganmao Qingre Keli by himself, the fever subsided compared with before, but new cough, expectoration of yellow sputum, and sore throat occurred. Later, the test for influenza A was positive, blood routine LYM: 0.66×109 / L, CRP: 56mg / L, and other tests were normal, considering influenza A virus infection. Current symptoms: fever, T: 37.7°C, cough, expectoration of yellow sticky sputum, accompanied by dry throat and sore throat, not afraid of cold, irritable, occasional palpitation, normal appetite and sleep, dry stool, normal urine, and the clinical symptom score was 9 points. 5 doses of the traditional Chinese medicine formula of the present invention were given. At the second diagnosis, the patient had no fever, T: 37.5°C, the cough and sore throat were relieved, and the clinical symptom score was 5 points. Example

[0069] Wang X, female, 32 years old. First diagnosis: Fever accompanied by cough for 3 days. Three days ago, the patient had fever without obvious cause, T: 37.9°C, accompanied by aversion to cold, not much sweating, sore throat. After taking Ganmao Qingre Granules by herself, the fever subsided compared with before, but new cough and yellow phlegm occurred. After taking Lianhua Qingwen Granules for sore throat, the symptoms did not improve significantly. The test for influenza A was positive, and the blood routine showed no obvious abnormality. It was considered an infection with influenza A virus. Present condition: Fever, T: 37.5°C, cough, sore throat, hoarseness, not much phlegm, dry mouth and bitter taste, occasional palpitation, normal appetite and sleep, normal defecation, yellow urine, and the clinical symptom score was 8 points. Five doses of the traditional Chinese medicine formula of the present invention were given. At the second diagnosis, the patient's fever subsided, and the cough and sore throat were significantly relieved, and the clinical symptom score was 2 points.

[0070] The above are only embodiments of the present invention. Specific technical solutions or common knowledge such as characteristics well known in the art are not described in detail here. It should be noted that for those skilled in the art, without departing from the technical solution of the present invention, several deformations and improvements can still be made, which should also be regarded as the protection scope of the present invention, and these will not affect the implementation effect of the present invention and the practicality of the patent. The protection scope required by this application should be based on the content of its claims, and the specific implementation manners described in the specification can be used to interpret the content of the claims.

Claims

1. A traditional Chinese medicine for treating the syndrome of external cold and internal heat caused by respiratory virus infection, characterized in that, The traditional Chinese medicine is composed of raw medicinal materials in the following weight ratio: 20 - 40 parts of gypsum fibrosum, 10 - 20 parts of mentha haplocalyx briq., 10 - 20 parts of cryptotympana pustulata fabricius, 5 - 15 parts of glycyrrhiza uralensis fisch., 10 - 20 parts of scutellaria baicalensis georgi, 5 - 15 parts of coptis chinensis franch., 10 - 20 parts of forsythia suspensa (thunb.) vahl, 10 - 20 parts of lonicera japonica thunb., 5 - 15 parts of platycodon grandiflorum (jacq.) a. dc.

2. The traditional Chinese medicine for treating the syndrome of external cold and internal heat caused by respiratory virus infection according to claim 1, wherein, The traditional Chinese medicine is composed of raw medicinal materials in the following weight ratio: 30 parts of gypsum fibrosum, 12 parts of mentha haplocalyx briq., 15 parts of cryptotympana pustulata fabricius, 10 parts of glycyrrhiza uralensis fisch., 15 parts of scutellaria baicalensis georgi, 10 parts of coptis chinensis franch., 15 parts of forsythia suspensa (thunb.) vahl, 15 parts of lonicera japonica thunb., 10 parts of platycodon grandiflorum (jacq.) a. dc.

3. The preparation method of a traditional Chinese medicine for treating the syndrome of external cold and internal heat caused by respiratory virus infection according to claim 1 or 2, characterized in that, It includes the following steps: S1. Preparation of raw medicinal materials Selection and cleaning: First, select the raw medicinal materials, remove the impurities, non - medicinal parts, and damaged or deteriorated raw medicinal materials; then clean the raw medicinal materials to remove the dust and soil on the surface; Cutting and pulverizing: Cut or pulverize the raw medicinal materials according to the characteristics and requirements of the raw medicinal materials; S2. Decoction Soaking: Put the raw medicinal materials prepared in step S1 into a container, add clear water and soak for 30 - 60 min to make the raw medicinal materials fully absorb water and expand; Decoction: Put the soaked raw medicinal materials and water into a decocting pot, heat to boiling and then turn to low heat to continue decocting; and control the decocting time and heat according to the nature and efficacy requirements of the medicinal materials; Combining decoction liquid: Combine the decoction liquids obtained from multiple decoctions to form a decoction liquid; S3. Concentration Filtration: Filter the combined decoction liquid to remove the impurities and suspended matters therein; Concentration: Concentrate the filtered decoction liquid by heating and evaporation to remove the excess water; S4. Drying Adopt spray drying or vacuum drying to remove the water in the medicinal liquid while maintaining the active ingredients and efficacy of the medicinal liquid; S5. Preparation and packaging According to the mass ratio of the raw medicinal materials, mix various traditional Chinese medicine powders together to prepare an oral dosage form and package it, which is the required traditional Chinese medicine.

4. The preparation method of a traditional Chinese medicine for treating the syndrome of external cold and internal heat caused by respiratory virus infection according to claim 3, wherein, In step S5, the prepared oral dosage form is one of granules, oral liquid, powder, tablets, capsules, pills.

5. The preparation method of a traditional Chinese medicine for treating the syndrome of cold pathogen externally and heat pathogen internally in respiratory virus infection according to claim 4, wherein, The prepared oral dosage form is granules and is packaged in bags.

6. Use of a traditional Chinese medicine for treating the syndrome of cold - encapsulated - fire due to respiratory virus infection according to claim 1 or 2 in the preparation of a drug for treating the syndrome of cold - encapsulated - fire due to respiratory virus infection with relatively strong heat - toxin.