Raw material low-temperature mixing device for preparing molecular imaging probe

By designing a stirring mechanism, adjustment assembly and refrigeration assembly for multiple bevel gear meshing transmissions in the molecular image probe preparation device, the problems of insufficient raw material sinking and temperature control in traditional devices are solved, and a more uniform and stable mixing effect is achieved .

CN119303467APending Publication Date: 2025-01-14BEIJING INST OF TECH
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Patent Information

Application Number
CN202411754314.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-02
Publication Date
2025-01-14

AI Technical Summary

Technical Problem

The traditional molecular image probe preparation device has problems such as insufficient bottoming, layering and temperature control during the mixing process of raw materials, which affects the mixing uniformity and the properties of the raw materials, resulting in poor mixing effect.

Method used

A low-temperature mixing device including a stirring mechanism, a adjustment assembly and a refrigeration assembly is designed. The stirring mechanism achieves uniform mixing of raw materials through multiple bevel gear meshing transmission and anchor stirring blades, and the adjustment assembly realizes a stirring shaft through an angle encoder and a controller. The refrigeration assembly maintains a low temperature environment through a spiral conduit and a thermal insulation cover.

Benefits of technology

Effectively prevent raw materials from sinking and delamination, improve mixing uniformity, maintain stable properties of raw materials, avoid deterioration or abnormal reactions caused by excessive temperature, and significantly improve the mixing effect of raw materials.

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Abstract

The invention discloses a low-temperature raw material mixing device for molecular imaging probe preparation, and relates to the technical field of raw material mixing for molecular imaging probe preparation, the low-temperature raw material mixing device comprises a mixing tank, the top of the mixing tank is detachably connected with a sealing cover, the top of the sealing cover is provided with a support frame, and the mixing tank is internally provided with a stirring mechanism for preventing raw materials from sinking to the bottom. The top of the supporting frame is provided with a driving mechanism used for driving the stirring mechanism to operate, the stirring mechanism is provided with an adjusting assembly, the adjusting assembly is used for adjusting forward and reverse rotation of the stirring mechanism, and the periphery of the mixing tank is provided with a refrigeration assembly. The problem that raw materials sink to the bottom due to single stirring motion in a traditional mixing device is effectively solved, the mixing effect of the raw materials in the mixing tank is effectively improved through the designed adjusting assembly, the conditions that the raw materials go bad or react abnormally due to the fact that the temperature is too high are avoided through the designed refrigerating assembly, and the mixing effect of the raw materials is further improved.
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Description

Technical Field

[0001] The invention relates to the technical field of raw material mixing for preparing molecular imaging probes, and in particular to a low-temperature raw material mixing device for preparing molecular imaging probes. Background Art

[0002] In the preparation process of molecular imaging probes, the mixing of raw materials is a key step. Traditional mixing devices have many shortcomings when dealing with the mixing of such raw materials. On the one hand, during the stirring process, the raw materials are prone to sink to the bottom, resulting in uneven mixing, which affects the quality and performance of the molecular imaging probe. On the other hand, ordinary stirring methods often cannot make the raw materials move fully in the entire mixing tank, especially the upper and lower layers of raw materials are difficult to mix effectively, which is prone to stratification problems. Moreover, traditional mixing devices lack effective temperature control methods. Excessive temperature will change the properties of the raw materials, such as changing their reaction activity, which may lead to raw material deterioration or abnormal reaction, affecting the raw material mixing effect and the quality of subsequent probe preparation. To this end, we propose a low-temperature raw material mixing device for the preparation of molecular imaging probes. Summary of the invention

[0003] The object of the present invention is to provide a low-temperature raw material mixing device for preparing molecular imaging probes.

[0004] To achieve the above-mentioned purpose, the present invention provides the following technical solutions: a low-temperature mixing device for raw materials for preparing molecular imaging probes, comprising a mixing tank, a cover detachably connected to the top of the mixing tank, a support frame provided on the top of the cover, a stirring mechanism for preventing the raw materials from sinking to the bottom provided inside the mixing tank, a driving mechanism for driving the stirring mechanism to operate provided on the top of the support frame, an adjusting component provided on the stirring mechanism, the adjusting component being used to adjust the forward and reverse rotation of the stirring mechanism, and a refrigeration component provided on the periphery of the mixing tank;

[0005] The stirring mechanism includes a stirring shaft, a paddle seat, a stirring plate, a gear frame and a sleeve, wherein the stirring shaft passes through the middle part of the cover through a bearing, and a first bevel gear is fixedly connected to a position of the stirring shaft near the end of the shaft shoulder, the paddle seat is arranged inside the mixing tank, and the paddle seat is fixed to a position of the stirring shaft near the bottom of the cover, the stirring plate is arranged on the paddle seat, the gear frame is welded to the end of the shaft shoulder of the stirring shaft, and second bevel gears meshing with the first bevel gear are arranged on both sides of the gear frame, the sleeve is sleeved on the periphery of the stirring shaft journal, a third bevel gear meshing with the second bevel gear is arranged at the top of the sleeve, and an anchor stirring blade is welded to the bottom of the sleeve;

[0006] The adjustment component includes an angle encoder and a controller, wherein the angle encoder is fixed on the periphery of the stirring shaft, and the controller is arranged in the middle of the top of the support frame. The controller is connected to the motor provided in the stirring mechanism through a power cable, and matching wireless communication modules are installed on the angle encoder and the controller. The refrigeration component includes a heat preservation cover and a conduit, wherein the heat preservation cover is arranged on the periphery of the mixing tank, the outer side of the conduit is fixed on the inner wall of the heat preservation cover, and the inner side of the conduit is close to the outer wall of the mixing tank.

[0007] As a further solution of the present invention: the top end of the stirring shaft cooperates with the bearing provided at the right end of the support frame, the two ends of the sleeve respectively cooperate with the bearings provided at the two ends of the stirring shaft neck, the edge of the blade seat is circularly provided with six branches evenly spaced, and the bottoms of the six branch ends are provided with mounting tubes.

[0008] As a further solution of the present invention: a corresponding stirring plate is provided in the installation cylinder, a pivot provided in the middle of the top of the stirring plate is fixed in the installation cylinder, and the stirring plate forms an angle of 45° with the branch.

[0009] As a further solution of the present invention: two ends of the bottom of the first bevel gear are respectively meshed with the tops of the two second bevel gears for transmission, and the bottoms of the two second bevel gears are meshed with two ends of the top of the third bevel gear for transmission.

[0010] As a further solution of the present invention: the driving mechanism includes a motor and a transmission belt, the motor is arranged at the top of the left end of the support frame, and the driving pulley provided at the bottom output end of the motor is connected to the driven pulley provided near the top position of the stirring shaft through the transmission belt.

[0011] As a further solution of the present invention: a cavity is provided inside the heat-insulating cover, and a through opening communicating with the cavity is provided on the top of the heat-insulating cover.

[0012] As a further solution of the present invention: the inner side of the heat preservation cover is welded to the outer side of the conduit, the conduit is arranged in a spiral form, its arrangement position is located outside the annular groove provided on the outer wall of the mixing tank, and both ends of the conduit pass through the heat preservation cover.

[0013] As a further solution of the present invention: an annular baffle is welded on the inner wall of the mixing tank, and the annular baffle is located above the stirring portion of the stirring plate.

[0014] As a further solution of the present invention: an observation window is provided on the side of the mixing tank, a feed port is also provided on the side of the mixing tank, and a solenoid valve is provided at the discharge port at the bottom of the mixing tank.

[0015] By adopting the above technical solution, compared with the prior art, the beneficial effects of the present invention are:

[0016] 1. The stirring mechanism designed in the present invention effectively solves the problem of raw material sinking to the bottom caused by a single stirring motion in a traditional mixing device. Through the meshing transmission between multiple bevel gears, when the stirring shaft rotates, the sleeve will rotate in the opposite direction to the stirring shaft. The reverse rotation of the sleeve drives the anchor stirring blade and the stirring plate to rotate in the opposite direction. This relatively reverse stirring motion can make the raw materials receive stirring forces in different directions, thereby improving the mixing uniformity of the raw materials. At the same time, when the anchor stirring blade starts to rotate in the opposite direction, due to its special shape and rotation direction, it will generate an upward thrust at the bottom of the mixing tank. This upward thrust will cause the raw materials to form an upward flow at the bottom of the mixing tank. Since the stirring plate driven by the stirring shaft is also performing a stirring action, the rotation of the stirring plate will cause the raw materials in the middle and upper parts of the mixing tank to flow. This synergistic effect enables the raw materials at the bottom that are pushed upward by the anchor stirring blade to be better mixed with the raw materials in other parts of the mixing tank, thereby preventing the raw materials from sinking to the bottom.

[0017] 2. The regulating component designed in the present invention effectively improves the mixing effect of the raw materials in the mixing tank. During the stirring process, the angle encoder monitors the rotation angle of the stirring shaft in real time and transmits the data to the controller through the wireless communication module. When the stirring shaft rotates to a preset number of circles, the controller controls the motor to change the rotation direction through the power cable, so that the stirring shaft is reversed. The forward and reverse rotations of the stirring shaft are performed alternately, making the movement of the raw materials in the mixing tank more complicated. When the raw materials are stratified, the forward and reverse rotations can make the upper and lower layers of the raw materials better mixed, thereby improving the mixing effect of the raw materials;

[0018] 3. The refrigeration component designed in the present invention avoids the deterioration of raw materials or abnormal reactions due to excessively high temperatures, and further improves the mixing effect of the raw materials. The refrigerant medium is passed through a conduit. Since the conduit is spirally wrapped around the outer wall of the mixing tank, the refrigerant medium and the mixing tank can have a larger contact area, thereby effectively absorbing the heat generated during the mixing process of the raw materials in the mixing tank. The thermal insulation cover can reduce the introduction of external heat and maintain a low temperature environment in the mixing tank. Under low temperature conditions, the properties of the raw materials for the preparation of molecular imaging probes will be more stable, and the reaction activity will also be affected, so that the raw material mixing process can proceed as expected, avoiding the deterioration of raw materials or abnormal reactions due to excessively high temperatures, thereby further improving the raw material mixing effect.

[0019] Other advantages, objectives and features of the present invention will be set forth in part in the following description and, in part, will be apparent to those skilled in the art based on an examination of the following or may be taught from the practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is a schematic diagram of the overall structure of the mixing device in an embodiment of the present invention;

[0021] Figure 2 is a cross-sectional view of a mixing tank according to an embodiment of the present invention;

[0022] Figure 3 The structure diagram of the stirring mechanism and the driving mechanism in the embodiment of the present invention is shown in FIG. Figure 1 ;

[0023] Figure 4 The structure diagram of the stirring mechanism and the driving mechanism in the embodiment of the present invention is shown in FIG. Figure 2 ;

[0024] Figure 5 An exploded schematic diagram of a stirring mechanism in an embodiment of the present invention;

[0025] Figure 6 It is a schematic diagram of the structure of the blade seat in an embodiment of the present invention;

[0026] Figure 7 This is a schematic diagram of the structure of a refrigeration assembly in an embodiment of the present invention;

[0027] Figure 8 Schematic diagram of the structure of the catheter in an embodiment of the present invention.

[0028] In the figure:

[0029] 1. Mixing tank; 101. Cover; 102. Support frame; 103. Ring groove; 104. Ring baffle; 105. Observation window; 106. Feed port; 107. Solenoid valve; 2. Stirring mechanism; 21. Stirring shaft; 211. First bevel gear; 22. Paddle seat; 221. Mounting cylinder; 23. Stirring plate; 24. Gear frame; 241. Second bevel gear; 25. Sleeve; 251. Third bevel gear; 26. Anchor stirring blade; 3. Driving mechanism; 31. Motor; 32. Transmission belt; 33. Active pulley; 34. Driven pulley; 4. Adjustment assembly; 41. Angle encoder; 42. Controller; 5. Refrigeration assembly; 51. Insulation cover; 511. Cavity; 512. Through port; 52. Conduit. DETAILED DESCRIPTION

[0030] The specific embodiments of the present invention will be further described below in conjunction with the accompanying drawings. It should be noted that the description of these embodiments is used to help understand the present invention, but does not constitute a limitation of the present invention.

[0031] In addition, the technical features involved in the various embodiments of the present invention described below can be combined with each other as long as they do not conflict with each other.

[0032] Please see attached Figure 1 -Attached Figure 8The present invention discloses a low-temperature mixing device for raw materials for preparing molecular imaging probes, comprising a mixing tank 1, a cover 101 is detachably connected to the top of the mixing tank 1, a support frame 102 is arranged on the top of the cover 101, a stirring mechanism 2 for preventing the raw materials from sinking to the bottom is arranged inside the mixing tank 1, a driving mechanism 3 for driving the stirring mechanism 2 to operate is arranged on the top of the support frame 102, an adjusting component 4 is arranged on the stirring mechanism 2, and the adjusting component 4 is used to adjust the forward and reverse rotation of the stirring mechanism 2, and a refrigeration component 5 is arranged on the periphery of the mixing tank 1;

[0033] The stirring mechanism 2 includes a stirring shaft 21, a paddle seat 22, a stirring plate 23, a gear frame 24 and a sleeve 25. The stirring shaft 21 passes through the middle of the cover 101 through a bearing, and a first bevel gear 211 is fixedly connected to the end of the stirring shaft 21 near the shoulder. The paddle seat 22 is arranged inside the mixing tank 1, and the paddle seat 22 is fixed to the position of the stirring shaft 21 near the bottom of the cover 101. The stirring plate 23 is arranged on the paddle seat 22. The gear frame 24 is welded to the end of the shoulder of the stirring shaft 21, and both sides of the gear frame 24 are provided with a second bevel gear 241 meshing with the first bevel gear 211. The sleeve 25 is sleeved on the outer periphery of the shaft neck of the stirring shaft 21, and a third bevel gear 251 meshing with the second bevel gear 241 is provided at the top of the sleeve 25, and an anchor stirring blade 26 is welded to the bottom of the sleeve 25.

[0034] The adjustment component 4 includes an angle encoder 41 and a controller 42. The angle encoder 41 is fixed to the periphery of the stirring shaft 21. The controller 42 is arranged in the middle of the top of the support frame 102. The controller 42 is connected to the motor 31 provided in the stirring mechanism 2 through a power cable, and the angle encoder 41 and the controller 42 are both installed with matching wireless communication modules. During the stirring process, the angle encoder 41 monitors the rotation angle of the stirring shaft 21 in real time, and transmits the data to the controller 42 through the wireless communication module. When the stirring shaft 21 rotates to a preset number of circles, the controller 42 controls the motor 31 to change the rotation direction through the power cable, so that the stirring shaft 21 is reversed. The forward and reverse rotations of the stirring shaft 21 are performed alternately, making the movement of the raw materials in the mixing tank 1 more complicated. When the raw materials are stratified, the forward and reverse rotations can make the upper and lower layers of the raw materials better mixed, thereby improving the raw material mixing effect. The refrigeration component 5 includes a heat preservation cover 51 and a conduit 52. The heat preservation cover 51 is arranged on the periphery of the mixing tank 1, the outer side of the conduit 52 is fixed to the inner wall of the heat preservation cover 51, and the inner side of the conduit 52 is close to the outer wall of the mixing tank 1.

[0035] In the first embodiment, the top of the stirring shaft 21 cooperates with the bearing provided at the right end of the support frame 102, and the two ends of the sleeve 25 cooperate with the bearings provided at the two ends of the shaft neck of the stirring shaft 21 respectively. The edge of the paddle seat 22 is circumferentially evenly spaced with six branches, and the bottom of the six branches is provided with a mounting cylinder 221. A corresponding stirring plate 23 is provided in the mounting cylinder 221. A pivot provided in the middle of the top of the stirring plate 23 is fixed in the mounting cylinder 221, and the stirring plate 23 forms an angle of 45° with the branch. The two ends of the bottom of the first bevel gear 211 are respectively meshed with the tops of the two second bevel gears 241 for transmission, and the bottoms of the two second bevel gears 241 are meshed with the two ends of the top of the third bevel gear 251 for transmission. The driving mechanism 3 includes a motor 31 and a transmission belt 32. The motor 31 is arranged at the top of the left end of the support frame 102, and the driving pulley 33 provided at the output end of the bottom of the motor 31 is connected to the driven pulley 34 provided near the top of the stirring shaft 21 through the transmission belt 32.

[0036] Specifically, when the motor 31 is started, the motor 31 drives the active pulley 33 to rotate, and the active pulley 33 drives the driven pulley 34 through the transmission belt 32, so that the stirring shaft 21 starts to rotate, and the rotation of the stirring shaft 21 drives the stirring plate 23 to stir the raw materials in the mixing tank 1. At the same time, the first bevel gear 211 rotates accordingly, and the two ends of the bottom of the first bevel gear 211 are respectively meshed with the tops of the two second bevel gears 241 for transmission, and the bottoms of the two second bevel gears 241 are meshed with the two ends of the top of the third bevel gear 251 at the top of the sleeve 25 for transmission. Due to this meshing relationship, when the stirring shaft 21 rotates, the sleeve 25 will rotate in the opposite direction to the stirring shaft 21. At the same time, an anchor stirring blade 26 is welded to the bottom end of the sleeve 25. The reverse rotation of the sleeve 25 drives the anchor stirring blade 26 and the stirring plate 23 to rotate in the opposite direction. The relatively reverse stirring motion can subject the raw materials to stirring forces in different directions, thereby improving the mixing uniformity of the raw materials. In addition, when the anchor stirring blade 26 starts to rotate in the opposite direction, due to its special shape and rotation direction, it will generate an upward thrust at the bottom of the mixing tank 1, and the part close to the bottom edge of the mixing tank 1 will scoop up the raw materials at the bottom. As the anchor stirring blade 26 continues to rotate, this upward thrust will cause the raw materials to form an upward flow at the bottom of the mixing tank 1. At the same time, since the stirring plate 23 driven by the stirring shaft 21 is also stirring, the rotation of the stirring plate 23 will cause the raw materials in the middle and upper parts of the mixing tank 1 to flow. This synergistic effect enables the raw materials at the bottom pushed upward by the anchor stirring blade 26 to be better mixed with the raw materials in other parts of the mixing tank 1, thereby preventing the raw materials from sinking to the bottom.

[0037] In the second embodiment, a cavity 511 is provided inside the heat preservation cover 51, and a through opening 512 communicating with the cavity 511 is provided at the top of the heat preservation cover 51. The inner side of the heat preservation cover 51 is welded to the outer side of the conduit 52. The conduit 52 is arranged in a spiral shape, and its arrangement position is located outside the annular groove 103 provided on the outer wall of the mixing tank 1, and both ends of the conduit 52 pass through the heat preservation cover 51.

[0038] Specifically, the refrigerant medium is passed through the conduit 52. Since the conduit 52 is spirally wound around the outer wall of the mixing tank 1, the refrigerant medium and the mixing tank 1 can have a larger contact area, thereby effectively absorbing the heat generated during the mixing process of the raw materials in the mixing tank 1. The heat preservation cover 51 can reduce the introduction of external heat and maintain the low temperature environment in the mixing tank 1. Under the low temperature environment, the properties of the raw materials for the preparation of molecular imaging probes will be more stable, and the reaction activity will also be affected, so that the raw material mixing process can proceed in the expected manner, avoiding the deterioration of the raw materials or abnormal reactions due to excessive temperature, thereby further improving the raw material mixing effect.

[0039] In the third embodiment, an annular baffle 104 is welded on the inner wall of the mixing tank 1, and the annular baffle 104 is located above the stirring portion of the stirring plate 23. An observation window 105 is provided on the side of the mixing tank 1, and a feed port 106 is also provided on the side of the mixing tank 1. A solenoid valve 107 is provided at the discharge port at the bottom of the mixing tank 1.

[0040] Specifically, during the raw material mixing process, the operator can observe the mixing of the raw materials in the tank in real time through the observation window 105. The solenoid valve 107 at the discharge port plays a key control role. After the mixing process is completed, precise control of the discharge is achieved by controlling the opening and closing of the solenoid valve 107.

[0041] Working principle:

[0042] First, the motor 31 is started, and the active pulley 33 at the bottom output end of the motor 31 drives the driven pulley 34 near the top position of the stirring shaft 21 through the transmission belt 32, so that the stirring shaft 21 starts to rotate, and the stirring shaft 21 drives the stirring plate 23 to stir, and the rotation of the stirring shaft 21 drives the stirring plate 23 on the paddle seat 22 to stir the raw materials in the mixing tank 1. When the stirring shaft 21 rotates, the stirring plate 23 can make the raw materials flow in the middle and upper part of the mixing tank 1. At the same time, the first bevel gear 211 on the stirring shaft 21 rotates accordingly, and the two ends of the bottom of the first bevel gear 211 are respectively meshed with the tops of the two second bevel gears 241 for transmission, and the bottoms of the two second bevel gears 241 are meshed with the two ends of the top of the third bevel gear 251 at the top of the sleeve 25 for transmission. The sleeve 25 and the stirring shaft 21 rotate in opposite directions. An anchor stirring blade 26 is welded at the bottom of the sleeve 25. The reverse rotation of the sleeve 25 drives the anchor stirring blade 26 and the stirring plate 23 to rotate in opposite directions. This relatively reverse stirring motion causes the raw materials to be subjected to stirring forces in different directions, thereby improving the mixing uniformity. When the anchor stirring blade 26 rotates in the reverse direction, an upward thrust is generated at the bottom of the mixing tank 1, and the portion thereof close to the bottom edge of the mixing tank 1 scoops up the raw materials at the bottom. As the anchor stirring blade 26 continues to rotate, an upward flow is formed at the bottom of the mixing tank 1, which cooperates with the flow of the middle and upper raw materials generated by the stirring of the stirring plate 23, so that the raw materials at the bottom can be better mixed with other raw materials, thereby preventing the raw materials from sinking to the bottom.

[0043] Secondly, during the stirring process, the angle encoder 41 installed on the periphery of the stirring shaft 21 monitors the rotation angle of the stirring shaft 21 in real time, and transmits the data to the controller 42 through the wireless communication module. When the stirring shaft 21 rotates to a preset number of circles, the controller 42 controls the motor 31 to change the rotation direction through the power cable, so that the stirring shaft 21 is reversed. The forward and reverse rotations of the stirring shaft 21 are performed alternately, making the movement of the raw materials in the mixing tank 1 more complicated. When the raw materials are stratified, the forward and reverse rotations can make the upper and lower layers of raw materials better mixed, thereby improving the raw material mixing effect. At the same time, the conduit 52 in the refrigeration component 5 is spirally wrapped around the outer wall of the mixing tank 1, and the outer side of the conduit 52 is fixed in the heat preservation cover 51. The inner side of the refrigeration medium is close to the outer wall of the mixing tank 1. When the refrigerant passes through the conduit 52, the spiral conduit 52 has a large contact area with the mixing tank 1, which can effectively absorb the heat generated during the mixing process of the raw materials in the mixing tank 1. The heat preservation cover 51 is arranged on the outer periphery of the mixing tank 1, and a cavity 511 is arranged inside the heat preservation cover 51 and a through hole 512 is arranged on the top. The heat preservation cover 51 can reduce the introduction of external heat, and cooperate with the conduit 52 to maintain the low temperature environment in the mixing tank 1. In the low temperature environment, the properties of the raw materials for the preparation of molecular imaging probes are more stable, avoiding the deterioration of the raw materials or abnormal reactions due to excessive temperature, ensuring that the raw material mixing process can proceed in the expected manner, and further improving the raw material mixing effect;

[0044] Finally, after the mixing process is completed, precise control of the discharge is achieved by controlling the opening and closing of the solenoid valve 107, and the entire workflow is now complete.

[0045] The above-mentioned front, back, left, right, top and bottom are all based on the figures in the specification. Figure 1 As a benchmark, according to the person's observation perspective, the side of the device facing the observer is defined as the front, the left side of the observer is defined as the left, and so on.

[0046] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the scope of protection of the present invention.

[0047] The embodiments of the present invention are described in detail above with reference to the accompanying drawings, but the present invention is not limited to the described embodiments.

[0048] It is apparent to those skilled in the art that various changes, modifications, substitutions and variations may be made to these embodiments without departing from the principles and spirit of the invention, and the changes still fall within the protection scope of the invention.

Claims

1. A low-temperature mixing device for raw materials for preparing molecular imaging probes, comprising a mixing tank (1), a cover (101) being detachably connected to the top of the mixing tank (1), a support frame (102) being provided on the top of the cover (101), characterized in that: The mixing tank (1) is provided with a stirring mechanism (2) for preventing the raw materials from sinking to the bottom, the top of the support frame (102) is provided with a driving mechanism (3) for driving the stirring mechanism (2) to operate, the stirring mechanism (2) is provided with an adjusting component (4), the adjusting component (4) is used to adjust the forward and reverse rotation of the stirring mechanism (2), and the periphery of the mixing tank (1) is provided with a refrigeration component (5); The stirring mechanism (2) comprises a stirring shaft (21), a paddle seat (22), a stirring plate (23), a gear frame (24) and a sleeve (25); the stirring shaft (21) passes through the middle of the cover (101) through a bearing, and a first bevel gear (211) is fixedly connected to a position of the stirring shaft (21) close to the end of the shaft shoulder; the paddle seat (22) is arranged inside the mixing tank (1), and the paddle seat (22) is fixed to a position of the stirring shaft (21) close to the bottom of the cover (101); the stirring plate (23) is fixed to a gear frame (24) and a sleeve (25); (23) is arranged on the paddle seat (22), the gear frame (24) is welded to the end of the shoulder of the stirring shaft (21), and second bevel gears (241) meshing with the first bevel gear (211) are provided on both sides of the gear frame (24), the sleeve (25) is sleeved on the outer periphery of the shaft neck of the stirring shaft (21), a third bevel gear (251) meshing with the second bevel gear (241) is provided at the top end of the sleeve (25), and an anchor stirring blade (26) is welded at the bottom end of the sleeve (25); The adjustment component (4) comprises an angle encoder (41) and a controller (42), wherein the angle encoder (41) is fixed to the periphery of the stirring shaft (21), and the controller (42) is arranged in the middle of the top of the support frame (102). The controller (42) is connected to the motor (31) provided in the stirring mechanism (2) through a power cable, and the angle encoder (41) and the controller (42) are both installed with matching wireless communication modules. The refrigeration component (5) comprises a heat preservation cover (51) and a conduit (52), wherein the heat preservation cover (51) is arranged on the periphery of the mixing tank (1), and the outer side of the conduit (52) is fixed to the inner wall of the heat preservation cover (51), and the inner side of the conduit (52) is in close contact with the outer wall of the mixing tank (1).

2. A low-temperature mixing device for raw materials for preparing molecular imaging probes according to claim 1, characterized in that: The top end of the stirring shaft (21) cooperates with the bearing provided at the right end of the support frame (102), and the two ends of the sleeve (25) respectively cooperate with the bearings provided at the two ends of the shaft neck of the stirring shaft (21). The edge of the paddle seat (22) is provided with six branches evenly spaced in a circular shape, and the bottoms of the ends of the six branches are provided with mounting tubes (221).

3. A low-temperature mixing device for raw materials for preparing molecular imaging probes according to claim 2, characterized in that: A corresponding stirring plate (23) is arranged in the installation cylinder (221); a pivot arranged in the middle of the top of the stirring plate (23) is fixed in the installation cylinder (221); and the stirring plate (23) forms an angle of 45° with the branch.

4. The low-temperature mixing device for raw materials for preparing molecular imaging probes according to claim 1, characterized in that: The two ends of the bottom of the first bevel gear (211) are respectively meshed with the tops of the two second bevel gears (241) for transmission, and the bottoms of the two second bevel gears (241) are meshed with the two ends of the top of the third bevel gear (251) for transmission.

5. The low-temperature mixing device for raw materials for preparing molecular imaging probes according to claim 1, characterized in that: The driving mechanism (3) comprises a motor (31) and a transmission belt (32); the motor (31) is arranged at the top of the left end of the support frame (102); and a driving pulley (33) provided at the bottom output end of the motor (31) is connected to a driven pulley (34) provided near the top end of the stirring shaft (21) through the transmission belt (32).

6. The low-temperature mixing device for raw materials for preparing molecular imaging probes according to claim 1, characterized in that: A cavity (511) is provided inside the heat-insulating cover (51), and a through opening (512) communicating with the cavity (511) is provided at the top of the heat-insulating cover (51).

7. A low-temperature mixing device for raw materials for preparing molecular imaging probes according to claim 6, characterized in that: The inner side of the heat-insulating cover (51) is welded to the outer side of the conduit (52); the conduit (52) is arranged in a spiral shape and is arranged at the periphery of the annular groove (103) provided on the outer wall of the mixing tank (1); and both ends of the conduit (52) pass through the heat-insulating cover (51).

8. The low-temperature mixing device for raw materials for preparing molecular imaging probes according to claim 7, characterized in that: An annular baffle (104) is welded to the inner wall of the mixing tank (1), and the annular baffle (104) is located above the stirring portion of the stirring plate (23).

9. A low-temperature mixing device for raw materials for preparing molecular imaging probes according to claim 8, characterized in that: The mixing tank (1) is provided with an observation window (105) on the side thereof, a material inlet (106) is also provided on the side thereof, and a solenoid valve (107) is provided at the material outlet at the bottom of the mixing tank (1).