Electrode plate, tumor electric field treatment system and temperature detection and signal control method

Abstract

The invention provides an electrode plate, a tumor electric field treatment system and a temperature detection and signal control method, the electrode plate comprises a flexible circuit board, a plurality of electrode units and a handshake chip, the plurality of electrode units and the handshake chip are arranged on the flexible circuit board, and the plurality of electrode units are divided into a plurality of row groups and a plurality of column groups on a circuit. A plurality of conductive traces are embedded in the flexible circuit board and comprise a plurality of grounding wires in one-to-one correspondence with the row groups, a plurality of dual-purpose signal wires in one-to-one correspondence with the column groups, a communication wire connected with corresponding parts of the handshake chip and a grounding trace for grounding the handshake chip; the grounding wire and each electrode unit of the corresponding row group are short-circuited and grounded, and the dual-purpose signal wire transmits an alternating-current electric signal to each electrode unit in a first mode and transmits a direct-current electric signal to each electrode unit in a second mode so as to collect a temperature signal.

Description

Technical Field

[0001] The present application relates to Tumor Treating Fields (TTF) technology, and in particular to an electrode sheet, a tumor treating field system, and a temperature detection and signal control method. Background Art

[0002] Tumor electric field therapy is a method of treating tumors by using low-intensity, medium- and high-frequency alternating electric fields to prevent the formation of spindle microtubules during mitosis of certain tumor cells, inhibit the separation of intracellular organelles during cell division, and induce apoptosis of cells during mitosis.

[0003] Compared with traditional cancer treatments, TTF has an innovative mechanism of action. Some physiological characteristics of tumor cells, such as geometric shape and high-frequency mitosis, make them susceptible to TTF. TTF disrupts the normal aggregation of tubulin by exerting directional forces on polar particles (such as macromolecules and organelles) within the cell. These processes may lead to physical damage to the cell membrane and cell apoptosis. At the end of cell mitosis, the structural morphology of the cleavage furrow will lead to an uneven distribution of the electric field around it. At the same time, under the influence of TTF, the electric field intensity at the cleavage furrow is significantly enhanced, and the charged substances in the cell move toward the cleavage furrow, which interferes with or even destroys the formation of the cell structure, and ultimately leads to cell division failure and apoptosis.

[0004] In the existing tumor electric field therapy system, an electric field generator is used to transmit the alternating current signal for tumor electric field therapy to the electrode sheet, and then the alternating electric field is applied to the patient's tumor site through the electrode sheet for tumor electric field therapy. When the tumor treatment electric field is applied to the patient's body, heat will accumulate at the application site, and the temperature will increase accordingly. Therefore, it is necessary to monitor the temperature at the application site. When the temperature is too high, the electric field strength needs to be adjusted in time to avoid the risk of skin burns caused by excessive temperature.

[0005] The tumor electric field therapy system includes at least one pair of electrode sheets, each of which has multiple electrode units. Even if the same alternating current signal is applied to each electrode unit, the heat generated by each electrode unit will be different due to its different position, that is, the temperature of each electrode unit on the entire electrode sheet will not be completely consistent. In this way, it is possible that the temperature of some electrode units in the entire electrode sheet exceeds the preset temperature, while the temperature of other electrode units is normal. In order to ensure that the tumor electric field therapy has a sufficiently long application time while avoiding low-temperature burns on the patient's body surface, it is necessary to implement separate control on the over-temperature electrode unit. However, for existing electrode sheets, implementing separate control on the electrode units requires that a conductive trace be set for each electrode unit in the substrate of the electrode sheet, which will increase the number of conductive traces in the electrode sheet substrate so that the electrode sheet is not easy to bend, and the cable electrically connected to the electrode sheet will also be thickened, which increases the overall weight of the electrode sheet, which is not conducive to the application of the electrode sheet.

[0006] Therefore, it is necessary to provide an electrode sheet, a tumor electric field therapy system, a temperature detection method, and a signal application method that use fewer conductive traces to perform partition control on multiple electrode units. Summary of the invention

[0007] The first object of the present application is to provide an electrode sheet to solve or eliminate the problems in the related art.

[0008] The second object of the present application is to provide a tumor electric field treatment system.

[0009] The third object of the present application is to provide a temperature detection method.

[0010] The fourth object of the present application is to provide a signal control method for tumor electric field therapy.

[0011] To achieve the above-mentioned purpose, the present application provides the following technical solutions: an electrode sheet for a tumor electric field therapy system, comprising: a plurality of electrode units, the plurality of electrode units are divided into a plurality of row groups and a plurality of column groups in circuit connection and are arranged in at least two row groups or three column groups in circuit connection; and a handshake chip, the handshake chip is configured to determine the connection status of the electrode sheet through handshake communication; and a flexible circuit board, which is configured for the handshake chip and the plurality of electrode units to be arranged thereon at intervals, and a plurality of conductive traces are embedded in the flexible circuit board, the plurality of conductive traces comprising: a plurality of ground wires, each corresponding to the plurality of row groups one by one, The grounding lines are all configured to short-circuit the corresponding parts of each electrode unit in the corresponding row group to ground; and multiple dual-purpose signal lines correspond to the multiple column groups one by one, and each of the dual-purpose signal lines is configured to: transmit AC signals to each electrode unit in the corresponding column group in a first mode, and transmit DC signals or temperature detection signals detected by each electrode unit in the corresponding column group in a second mode; and ground traces, which are configured to ground the handshake chip; and communication lines, which are electrically connected to the corresponding parts of the handshake chip.

[0012] Furthermore, the number of the dual-purpose signal lines is related to the number of the column groups into which the electrode unit is divided, and the number of the ground lines is related to the number of the row groups into which the electrode unit is divided.

[0013] Furthermore, the number of the dual-purpose signal lines is equal to the number of column groups into which the electrode units are divided.

[0014] Furthermore, the number of the grounding lines is equal to the number of the row groups into which the electrode units are divided.

[0015] Furthermore, each of the electrode units includes a dielectric element for transmitting an alternating current signal and a temperature sensor having a signal terminal and a ground terminal, and the temperature sensor is used to detect the temperature of the corresponding electrode unit.

[0016] Furthermore, the dielectric element of each electrode unit is short-circuited with the signal end of the temperature sensor.

[0017] Furthermore, each of the electrode units also includes a diode connected in series with the temperature sensor, and the temperature sensor is grounded through the diode connected in series with the temperature sensor.

[0018] Furthermore, the dielectric elements of the plurality of electrode units in the same column group are connected in parallel to the same dual-purpose signal line of the flexible circuit board, the dielectric elements of the plurality of electrode units in different column groups are connected in parallel through different dual-purpose signal lines of the flexible circuit board, the dielectric elements of the plurality of electrode units in the same row group are connected in parallel through different dual-purpose signal lines of the flexible circuit board, and the dielectric elements of the plurality of electrode units in different row groups and different column groups are connected in parallel to different dual-purpose signal lines of the flexible circuit board.

[0019] Furthermore, the dielectric elements of the plurality of electrode units in the same column group and the signal ends of the respective temperature sensors are connected in parallel through the same dual-purpose signal line of the flexible circuit board, and the dielectric elements of the plurality of electrode units in different column groups and the signal ends of the respective temperature sensors are connected in parallel through different dual-purpose signal lines of the flexible circuit board.

[0020] Furthermore, the ground ends of the temperature sensors of the multiple electrode units located in the same row group are short-circuited through the same ground line of the flexible circuit board, and the ground ends of the temperature sensors of the multiple electrode units located in the same column group are connected in parallel through different ground lines of the flexible circuit board; the signal ends of the temperature sensors of the multiple electrode units located in the same row group are connected in parallel through different dual-purpose signal lines of the flexible circuit board, and the signal ends of the temperature sensors of the multiple electrode units located in the same column group are short-circuited through the same dual-purpose signal line of the flexible circuit board.

[0021] Furthermore, the dielectric elements of the plurality of electrode units in the same row group are respectively connected in parallel through different dual-purpose signal lines of the flexible circuit board, and the dielectric elements of the plurality of electrode units in the same column group are short-circuited through the same dual-purpose signal line of the flexible circuit board.

[0022] Furthermore, the temperature signals detected by the temperature sensors in each of the row groups are sampled simultaneously after the handshake chip completes the handshake communication.

[0023] Furthermore, the sampled temperature signal detected by the temperature sensor is used to characterize the type of the electrode sheet.

[0024] Furthermore, the handshake chip has a ground pin electrically connected to the ground trace and a communication pin electrically connected to the communication line, and the ground pin is connected to one of the multiple ground lines through the ground trace.

[0025] Furthermore, the handshake chip stores energy when the communication line transmits a high level and releases energy when the communication line transmits a low level.

[0026] Furthermore, the sampled temperature signal detected by the temperature sensor is also used to indicate whether the electrode sheet has a temperature abnormality.

[0027] According to the electrode sheet of the present application, its flexible circuit board is provided with a plurality of dual-purpose signal lines, which can transmit AC signals in a first mode and transmit DC signals or collect temperature detection signals of each electrode unit in a second mode. There is no need to set a separate conductive trace used only for transmitting AC signals, which can reduce the number of wire cores of the wires connecting the electrode sheet and the adapter and simplify the wiring design of the flexible circuit board of the electrode sheet.

[0028] In order to achieve the above-mentioned purpose, the present application also provides the following technical solution: a tumor electric field treatment system, comprising at least one pair of the aforementioned electrode sheets.

[0029] Furthermore, it also includes: an electric field generator, which is configured to apply an alternating current signal to multiple electrode units of the electrode sheet via the dual-purpose signal line of the electrode sheet; and an adapter, which is connected between the electrode sheet and the electric field generator and is configured to transmit the alternating current signal generated by the electric field generator to the multiplexed dual-purpose signal line of the electrode sheet, and is also configured to receive the temperature signal detected by the multiplexed dual-purpose signal line output of the electrode sheet, and is also configured to perform handshake communication with the handshake chip, and to sample the temperature signal detected by each electrode unit in each of the row groups in a time-sharing manner after completing the handshake communication.

[0030] Furthermore, the adapter includes: an AC signal line configured to apply an alternating current signal to each of the electrode units in the corresponding column group through the plurality of dual-purpose signal lines.

[0031] Furthermore, the adapter also includes the switch unit, which includes: multiple groups of grounding switches, each group of grounding switches is electrically connected to a corresponding electrode sheet and includes multiple grounding switches, and the multiple grounding switches in each group of grounding switches are respectively electrically connected to the multiple grounding lines of the corresponding electrode sheet and are configured to control the conduction or disconnection of the multiple grounding lines.

[0032] Furthermore, the adapter also includes: multiple groups of analog-to-digital converters, which are electrically connected to the multiple dual-purpose signal lines of the corresponding electrode sheets, respectively, and are configured to receive the temperature signals detected by the multiple dual-purpose signal lines of the corresponding electrode sheets and convert the temperature signals from analog signals to digital signals, wherein each group of analog-to-digital converters includes multiple detection channels, and each detection channel is used to connect a corresponding one of the multiple dual-purpose signal lines.

[0033] Furthermore, the switch unit also includes: multiple groups of bidirectional switching switches, corresponding one-to-one to the multiple electrode sheets, each group of the bidirectional switching switches includes multiple bidirectional switching switches, and the multiple bidirectional switching switches in each group of bidirectional switching switches are respectively electrically connected one-to-one with the multiple dual-purpose signal lines of the corresponding electrode sheets; wherein each of the bidirectional switching switches also has a sampling end electrically connected to a corresponding detection channel in the corresponding analog-to-digital converter and an input end electrically connected to the AC signal line.

[0034] Furthermore, the adapter also includes: a first controller, which is connected to the multiple groups of grounding switches and the multiple groups of bidirectional switching switches respectively, and is configured to: control the opening and closing states of the corresponding groups of grounding switches in a cyclic manner, thereby sequentially and individually conducting each of the multiple grounding wires of the corresponding electrode sheet; and control the switching states of the corresponding groups of bidirectional switching switches, so that each of the bidirectional switching switches is placed at the sampling end to output the detected temperature signal or at the input end to transmit the AC signal; and configure the switching state of the corresponding group of grounding switches upon receiving the handshake signal sent by the electric field generator. The handshake chip is powered on by configuring the switching state of each grounding switch in the corresponding group and the switching state of each double-cut switch in the corresponding group of bidirectional switches, and the analog-to-digital converter of the corresponding group samples the temperature signals detected by each temperature sensor in the corresponding row group through the corresponding detection channel at the same time, and then performs analog-to-digital conversion on the temperature signals obtained to obtain multiple digital signals.

[0035] Furthermore, the adapter also includes: a first communication unit, configured to obtain digital signals output by the multiple groups of analog-to-digital converters and send the digital signals to the electric field generator.

[0036] Furthermore, the electric field generator is also configured to control or adjust the alternating current signal applied to the corresponding electrode unit among the plurality of electrode units of the corresponding electrode sheet according to the received digital signal.

[0037] Furthermore, the first communication unit is controlled by the first controller and serially transmits the digital signal converted by the analog-to-digital converter.

[0038] Furthermore, the first controller is also used to identify the type of the corresponding electrode sheet according to the multiple digital signals.

[0039] Furthermore, the first controller is also used to determine whether the temperature of the corresponding electrode sheet is abnormal according to the multiple digital signals during the process of the electric field generator transmitting the alternating electric signal to the corresponding electrode sheet.

[0040] Furthermore, the first controller is also used to send the multiple digital signals to the electric field generator so that the electric field generator can identify the type of the corresponding electrode sheet according to the multiple digital signals.

[0041] Furthermore, the electric field generator is also used to determine whether the corresponding electrode sheet has temperature abnormality according to the multiple digital signals during the process of transmitting the alternating electric signal to the corresponding electrode sheet.

[0042] Furthermore, the adapter includes an AC signal line, and the AC signal line is configured to provide alternating current signals to each of the electrode units in the corresponding column group through the multiple dual-purpose signal lines.

[0043] To achieve the above-mentioned purpose, the present application also provides the following technical solutions: a temperature detection method, applied to the aforementioned electrode sheet or to the aforementioned tumor electric field therapy system, the method comprising the following steps: performing handshake communication with the handshake chip through the adapter to determine the connection status of the corresponding electrode sheet; when each of the electrode sheets is normally connected to the adapter, the temperature signals detected by each electrode unit in each of the row groups are sampled in a time-sharing manner by configuring the on and off states of the multi-channel ground lines and the multi-channel dual-purpose signal lines of the electrode sheets.

[0044] Furthermore, the multiple dual-purpose signal lines of the electrode sheet are all led to their respective sampling ends, each of the multiple grounding lines of the electrode sheet is turned on in sequence, and the temperature signals detected by each electrode unit of the electrode sheet are collected row by row through the multiple dual-purpose signal lines.

[0045] To achieve the above-mentioned purpose, the present application also provides the following technical solutions: a signal control method for tumor electric field therapy, applied to the aforementioned electrode sheet or to the aforementioned tumor electric field therapy system. When the handshake chip confirms that the electrode sheet is normally connected, the signal for tumor electric field therapy is achieved by combining and controlling the conduction and disconnection of multiple dual-purpose signal lines and multiple ground lines, and by using multiple dual-purpose signal lines to realize cyclic switching between applying alternating current signals and applying direct current signals to each electrode unit of the electrode sheet for collecting or transmitting detected temperature signals.

[0046] Furthermore, the process of applying an alternating current signal to each electrode unit of the electrode sheet includes the following steps: disconnecting the multiple ground lines that are electrically connected one-to-one to the electrode units in each row group of the electrode sheet, and at the same time connecting the multiple dual-purpose signal lines that are electrically connected one-to-one to the electrode units in each column group of the electrode sheet to their respective input ends to transmit the alternating current signal to each electrode unit through the multiple dual-purpose signal lines that are electrically connected to the electrode sheet.

[0047] Furthermore, the process of transmitting the detected temperature signal to each electrode unit of the electrode sheet includes the following steps: connecting the multiple dual-purpose signal lines connected to the electrode units in each column group of the electrode sheet to their respective collection ends to transmit a direct current signal to each electrode unit through the multiple dual-purpose signal lines electrically connected to the electrode sheet; and sequentially and time-sharingly connecting one of the multiple grounding lines electrically connected to the electrode units in each row group of the electrode sheet in a one-to-one correspondence to complete the transmission of the detected temperature signals of all the electrode units in each row group of the electrode sheet row by row through the multiple dual-purpose signal lines electrically connected to the electrode sheet.

[0048] The above description is only an overview of the technical solution of the present application. In order to more clearly understand the technical means of the present application, it can be implemented in accordance with the contents of the specification. In order to make the above and other purposes, features and advantages of the present application more obvious and easy to understand, the specific implementation methods of the present application are listed below. BRIEF DESCRIPTION OF THE DRAWINGS

[0049] Figure 1 A schematic diagram of a tumor electric field treatment system according to an embodiment of the present application, wherein a schematic diagram of the spatial structure of the electrode sheet according to the first embodiment is shown;

[0050] Figure 2 For use in this application Figure 1 A schematic diagram of the structural layout of a modified embodiment of the electrode sheet of the first embodiment of the tumor electric field treatment system shown;

[0051] Figure 3 For this application Figure 1The circuit connection diagram of the tumor electric field system shown in FIG. Figure 1 The electrode sheet of the first embodiment shown in Figure 2 The electrode sheet of the modified embodiment shown in Figure 1 A circuit connection diagram of the adapter of the first embodiment shown in FIG.

[0052] Figure 4 For this application Figure 3 A schematic block diagram of the internal structure of the adapter shown;

[0053] Figure 5 For this application Figure 1 A schematic block diagram of the internal structure of an electric field generator of a tumor electric field treatment system is shown;

[0054] Figure 6 and Figure 3 Similarly, FIG. 1 is a circuit connection diagram of the tumor electric field treatment system according to the second embodiment of the present application, which shows the electrode sheet and the second embodiment of the tumor electric field treatment system according to the present application. Figure 3 The circuit connection diagram of the adapter shown;

[0055] Figure 7 and Figure 3 Similarly, FIG. 1 is a circuit connection diagram of the tumor electric field treatment system according to the third embodiment of the present application, which shows the electrode sheet and the third embodiment of the tumor electric field treatment system according to the present application. Figure 3 The circuit connection diagram of the adapter shown;

[0056] Figure 8 and Figure 3 Similarly, the circuit connection diagram of the tumor electric field treatment system of the fourth embodiment of the present application is shown, which shows the electrode sheet and the fourth embodiment of the tumor electric field treatment system of the present application. Figure 3 The circuit connection diagram of the adapter shown;

[0057] Fig. 9 and Figure 3 Similarly, FIG. 1 is a circuit connection diagram of the tumor electric field treatment system of the fifth embodiment of the present application, which shows the electrode sheet and the fifth embodiment of the tumor electric field treatment system of the present application. Figure 3 The circuit connection diagram of the adapter shown;

[0058] Fig.10 A schematic diagram of a flow chart of a temperature detection method of a tumor electric field treatment system of the present application;

[0059] Fig.11 The workflow diagram of the tumor electric field treatment system for this application;

[0060] Fig.12Another schematic diagram of the process of temperature detection method of the tumor electric field treatment system of the present application;

[0061] Fig.13 A schematic diagram of the flow chart of the control method for applying an alternating current signal for electric field therapy of tumors in this application;

[0062] Fig.14 This is a flow chart of the signal control method for tumor electric field therapy in this application;

[0063] Fig.15 This is a flow chart of the electrode temperature detection method of the present application;

[0064] Fig.16 This is a schematic flow chart of the method for applying alternating current signals for electric field therapy of tumors in this application.

[0065] Description of reference numerals:

[0066] Tumor electric field treatment system 100, electrode sheets 10, 10', 10D, 10E, 10F, 10H, flexible circuit boards 11, 11D, 11E, 11F, 11H, connecting parts 111, 111', wiring parts 112, 112', bridging parts 113, 113', trunks 114, 114', branches 115, 115', first intervals D1, D1', second intervals D2, D2', electrode units 12, 12', first cables 13, 13', temperature sensors 14, and ground terminals 1 4-1, signal terminal 14-2, dielectric element 15, diode 16, handshake chip 17, ground trace 171, communication line 172, ground line 18, first ground line 18-1, second ground line 18-2, third ground line 18-3, fourth ground line 18-4, dual-purpose signal line 19, first dual-purpose signal line 19-1, second dual-purpose signal line 19-2, third dual-purpose signal line 19-3, fourth dual-purpose signal line 19-4, fifth dual-purpose signal line 19-5, adapter 20, second cable 21, A controller 22, an analog-to-digital converter 23, a voltage-dividing resistor 24, a grounding switch 25, a first grounding switch 25-1, a second grounding switch 25-2, a third grounding switch 25-3, a fourth grounding switch 25-4, a bidirectional switch 26, a first bidirectional switch 26-1, a second bidirectional switch 26-2, a third bidirectional switch 26-3, a fourth bidirectional switch 26-4, a fifth bidirectional switch 26-5, a first communication unit 27, an AC signal line 28, a first power supply module 29, a communication Transmission line 211, electric field generator 30, second power supply module 31, second controller 32, second communication unit 33, AC signal generator 34, AC signal switch 35, first AC signal switch 35-1, first AC signal switch 35-2, first AC signal switch 35-3, first AC signal switch 35-4, first connector 40, 40D, 40E, 40F, 40H, first plug 41, 41', first socket 42, second connector 50, second plug 51, second socket 52. DETAILED DESCRIPTION

[0067] The following embodiments of the technical solution of the present application will be described in detail in conjunction with the accompanying drawings. The following embodiments are only used to more clearly illustrate the technical solution of the present application, and are therefore only used as examples, and cannot be used to limit the scope of protection of the present application.

[0068] Figure 1 FIG. 1 is a schematic diagram of a tumor electric field treatment system 100 according to an embodiment of the present application. Figure 1As shown, the tumor electric field treatment system 100 includes: at least one pair of electrode sheets 10, an adapter 20 connected to the electrode sheets 10, and an electric field generator 30 connected to the adapter 20. The electric field generator 30 generates an alternating current signal for tumor treatment and applies the alternating current signal to the electrode sheets 10 through the adapter 20, so that a therapeutic electric field is generated between the electrode sheets 10 arranged in pairs. The adapter 20 is electrically connected between the electrode sheets 10 and the electric field generator 30, and is used to transmit the alternating current signal generated by the electric field generator 30 to the electrode sheets 10. In other words, the electric field generator 30 is capable of generating an alternating current signal, and the generated alternating current signal is transmitted to each electrode sheet 10 through the adapter 20, so that a therapeutic electric field for treating tumors is generated between the same pair of electrode sheets 10. As shown in FIG. Figure 1 As shown, in this embodiment, the number of electrode sheets 10 is 4. From the perspective of spatial structural arrangement, each electrode sheet 10 includes a plurality of electrode units 12 that are both axially symmetrically arranged and centrally symmetrically arranged and of the same number, a plurality of connecting portions 111 located between two adjacent electrode units 12, a bridging portion 113 erected between two adjacent connecting portions 111, a wiring portion 112 connected to the bridging portion 113, and a first cable 13 connected to the wiring portion 112. The bridging portion 113 and the wiring portion 112 are arranged vertically to form a "T" shape. The bridging portion 113 is erected between two adjacent connecting portions 111. Each electrode unit 12 of the electrode sheet 10 is electrically connected to the adapter 20 via a first cable 13 having 10-core conductors.

[0069] Each electrode unit 12 has a temperature sensor 14 and a dielectric element 15. The temperature sensor 14 is used to detect the temperature of the patient's body surface where the electrode unit 12 is applied. It can be a thermistor element or other temperature sensors other than thermistors, and can be set at any position on the electrode unit 12. The dielectric element 15 is used to apply an alternating current signal to the patient's tumor site. The dielectric element 15 can be a dielectric ceramic sheet or a polymer dielectric layer composed of a polymer material. In this embodiment, each dielectric element 15 has a through-hole (unnumbered) arranged in the middle to accommodate a corresponding temperature sensor 14. Each electrode unit 12 can also include a diode 16 connected in series with the temperature sensor 14, which can prevent the reverse flow of current to prevent the detection signal from other electrode units 12 from affecting the temperature sensor 14. The ground terminal 14-1 of the temperature sensor 14 is connected in series with the anode of the diode 16 and is grounded through the cathode of the diode 16.

[0070] In the first mode, the electrode unit 12 applies an alternating current signal through the dielectric element 15; in the second mode, the temperature sensor 14 is used to detect or collect the temperature of the patient's body surface to which the corresponding electrode unit 12 is attached; in the third mode, the application of the alternating current signal is stopped and the temperature detection and collection are stopped. The first mode, the second mode, and the third mode do not overlap each other in time periods. That is, the time period in which the dielectric element 15 of the electrode unit 12 applies the alternating current signal is staggered and does not overlap with the time period in which the temperature sensor 14 detects the temperature. The electrode unit 12 can switch cyclically between applying an alternating current signal through its dielectric element 15 and detecting the temperature through its temperature sensor 14, that is, the electrode unit 12 can switch cyclically between the first mode and the second mode. The electrode unit 12 can also switch cyclically between the first mode, the second mode, and the third mode, that is, the electrode unit 12 switches cyclically between applying an alternating current signal through the dielectric element 15, collecting or detecting the temperature through the temperature sensor 14, and stopping applying the alternating current signal and collecting the temperature.

[0071] Each electrode sheet 10 includes an electrode array (not numbered) consisting of 20 electrode units 12. The electrode array (not numbered) also has a flexible circuit board 11 including a connecting portion 111, a wiring portion 112, and a bridging portion 113. The 20 electrode units 12 are distributed in an electrode array (not numbered) arranged in four rows and six columns in an interval shape. Specifically, four electrode units 12 are arranged in each of the first and last rows, and six electrode units 12 are arranged in each of the two middle rows. The four electrode units 12 in the first row are respectively located in each of the second to fifth columns, the six electrode units 12 in each of the two middle rows are respectively located in each of the first to sixth columns, and the four electrode units 12 in the last row are also respectively located in each of the second to fifth columns. The connection portion 111 is only located between two adjacent electrode units 12 arranged in the column direction in each of the third and fourth columns, and between the remaining two adjacent electrode units 12 in the row direction except the two electrode units 12 in the third and fourth columns in each row. That is, the two adjacent electrode units 12 in the third and fourth columns are only connected in the column direction through the connection portion 111, and are disconnected in the row direction and not connected by the connection portion 111; the electrode units 12 in the first, second, fifth and sixth columns are only connected to the electrode units 12 adjacent to them in the row direction through the connection portion 111 arranged in the horizontal direction, and the electrode units 12 adjacent to them in the column direction are disconnected. That is to say, the two adjacent electrode units 12 in the first, second, fifth and sixth columns are disconnected.

[0072] The electrode units 12 located in the third column and the connecting portions 111 located between the electrode units 12 in the column and arranged longitudinally, and the electrode units 12 located in the fourth column and the connecting portions 111 located between the electrode units 12 in the column and also arranged longitudinally all constitute the trunk 114 of the electrode array (not numbered). The connecting portions 111 located on the opposite sides of the electrode units 12 in the third column and the fourth column and connected to the electrode units 12 in the third column and the fourth column respectively through the connecting portions 111 arranged transversely and the electrode units 12 connected to the connecting portions 111 arranged transversely all constitute the branches 115 of the electrode array (not numbered). That is, in this embodiment, the electrode array (not numbered) includes two trunks 114 and a plurality of branches 115 extending laterally from the two trunks 114. Each branch 115 has a free end away from the trunk 114, and the free ends of adjacent branches 115 are arranged in a disconnected state, and the position and distance between adjacent branches 115 can be freely adjusted according to the actual use scenario. Specifically, one trunk 114 is composed of the electrode units 12 located in the third column and the connecting portions 111 located between the adjacent electrode units 12 in the column and arranged in a longitudinal direction, and another trunk 114 is composed of the electrode units 12 located in the fourth column and the connecting portions 111 located between the adjacent electrode units 12 in the column and arranged in a longitudinal direction. The remaining electrode units 12 connected to the trunk 114 through the connecting portions 111 arranged in a transverse direction and the connecting portions 111 arranged in a transverse direction are all branches 115.

[0073] Specifically, the branches 115 are: a connecting portion 111 extending laterally to the left from the electrode unit 12 in the first row of the third column and located in the first row, and an electrode unit 12 connected to the connecting portion 111 and located in the second column of the first row; two connecting portions 111 extending laterally to the left from the electrode unit 12 in the second row of the third column and located in the second row, and two electrode units 12 located in the first column of the second row and the second column of the second row; two connecting portions 111 extending laterally to the left from the electrode unit 12 in the third row of the third column and located in the third row, and two electrode units 12 located in the first column of the third row and the second column of the third row; a connecting portion 111 extending laterally to the left from the electrode unit 12 in the fourth row of the third column and located in the fourth row, and The electrode unit 12 in the second column of the fourth row; a connecting portion 111 extending laterally to the right from the electrode unit 12 in the first row of the fourth column and located in the first row, and an electrode unit 12 located in the fifth column of the first row; two connecting portions 111 extending laterally to the right from the electrode unit 12 in the second row of the fourth column and located in the second row, and two electrode units 12 located in the fifth column of the second row and the sixth column of the second row; two connecting portions 111 extending laterally to the right from the electrode unit 12 in the third row of the fourth column and located in the third row, and two electrode units 12 located in the fifth column of the third row and the sixth column of the third row; a connecting portion 111 extending laterally to the right from the electrode unit 12 in the fourth row of the fourth column and located in the fourth row, and an electrode unit 12 located in the fifth column of the fourth row.

[0074] The electrode array (unnumbered) is divided into a symmetrical left part including three columns on the left and a right part including three columns on the right, and the left part and the right part are connected only by a bridge portion 113. The left part is composed of a trunk 114 located in the third column and a plurality of branches 115 extending laterally to the left from the trunk 114, and the right part is composed of a trunk 114 located in the fourth column and a plurality of branches 115 extending laterally to the right from the trunk 115. The two trunks 114 are connected by a bridge portion 113 arranged therebetween. Specifically, the two trunks 114 are electrically connected by a bridge portion 113 arranged between a connection portion 111 connecting the electrode unit 12 of the third column and the second row with the electrode unit 12 of the third column and the third row with the connection portion 111 connecting the electrode unit 12 of the fourth column and the second row with the electrode unit 12 of the fourth column and the third row. The connecting portion 111 connecting the electrode unit 12 in the second row of the third column and the electrode unit 12 in the third row of the third column, the connecting portion 111 connecting the electrode unit 12 in the second row of the fourth column and the electrode unit 12 in the third row of the fourth column, and the bridging portion 113 are generally arranged in an "H" shape. In other embodiments, the bridging portion 113 may also be arranged between an electrode unit 12 located in the third column and an electrode unit 12 located in the fourth column. Optionally, the bridging portion 113 is arranged between two electrode units 12 located in the third column and the fourth column and adjacent in the row direction.

[0075] Each electrode unit 12 can be divided into an electrode unit 12 located at the periphery and an electrode unit 12 located at the center according to its position in the electrode array (unnumbered). The electrode units 12 located at the periphery include four electrode units 12 located in the first row, two electrode units 12 located at opposite ends of the second row, two electrode units 12 located at opposite ends of the third row, and four electrode units 12 located in the fourth row. The electrode units 12 located at the center include four electrode units 12 located in the middle of the second row and four electrode units 12 located in the middle of the third row. Some adjacent two electrode units 12 in the plurality of electrode units 12 located at the periphery are connected by a laterally arranged connecting portion 111, and some adjacent two electrode units 12 are arranged in a disconnected state. Two adjacent electrode units 12 in the plurality of electrode units 12 located at the periphery that are connected by a connecting portion 111 are two electrode units 12 that are adjacent in some rows. Specifically, among the plurality of electrode units 12 located at the periphery, two electrode units 12 adjacent in the column direction and adjacent in the diagonal direction are all arranged in a disconnected state; some two electrode units 12 adjacent in the row direction are also arranged in a disconnected state; only some two electrode units 12 adjacent in the row direction are connected by a laterally extending connection portion 111. Among the plurality of electrode units 12 located at the center, only two electrode units 12 adjacent in the column direction located on the trunk 114 are connected by a longitudinally arranged connection portion 111, and only two electrode units 12 adjacent in the row direction located on the branch 115 are connected by a laterally arranged connection portion 111.

[0076] The electrode array (unnumbered) also has intervals (unnumbered) formed between a number of electrode units 12 distributed at intervals, which can allow moisture on the patient's body surface to escape, heat exchange between the patient's skin and the outside world, or allow the patient's skin to breathe freely, and also allow the positions and spacings between the branches 115 to be freely adjusted, and can also prevent the electrode sheet 10 from wrinkling when applied. The intervals (unnumbered) include a first interval D1 located between the two trunks 114 and a second interval D2 located between the branches 115. The first interval D1 is located between the third column of electrode units 12 and the fourth column of electrode units 12, and the second interval D2 is located between the electrode units 12 in adjacent rows. That is, along the row upward, the electrode unit 12 located in the third column is disconnected from the adjacent electrode unit 12 located in the fourth column, and no connecting portion 111 is provided, but the aforementioned first interval D1 is formed; and along the column upward, only the two adjacent electrode units 12 in the third column and the fourth column are connected by the connecting portion 111, and the two adjacent electrode units 12 in the column direction in each of the other four columns are not connected by the connecting portion 111 but form the aforementioned second interval D2. The setting of the first and second intervals D1 and D2 can also increase the degree of freedom of some electrode units 12, and can also avoid wrinkles when attaching the electrode sheet 10.

[0077] The electrode sheet 10 also includes a handshake chip 17 disposed on the flexible circuit board 11 and used to confirm its connection status. The handshake chip 17 can communicate with the electric field generator 30 through the adapter 20 to determine the connection status between the electrode sheet 10 and the adapter 20. The electric field generator 30 of the tumor electric field treatment system 100 first sends a handshake communication signal to the handshake chip 17 of the electrode sheet 10 through the adapter 20, and determines the connection status of the electrode sheet 10 based on whether the feedback from the handshake chip 17 is received. After confirming that the electrode sheet 10 is connected normally through the handshake chip 17, the electric field generator 30 of the tumor electric field treatment system 100 applies an AC signal to the dielectric element 15 of the electrode sheet 10 or transmits a DC signal to each temperature sensor 14 of the electrode sheet 10 to collect temperature detection signals. The handshake chip 17 can be an EEPROM with encryption function.

[0078] In some other embodiments, the tumor electric field treatment system 100 may also have more or fewer electrode sheets 10. In some other embodiments, each pair of electrode sheets 10 has the same or different numbers of electrode units 12, and different pairs of electrode sheets 10 may also have different numbers of electrode units 12. In some other embodiments, the 20 electrode units 12 may also be arranged in other ways. Of course, in some other embodiments, the electrode sheets 10 may also have other numbers of electrode units 12. In some other embodiments, the 20 electrode units 12 may also be arranged in other ways, such as Figure 2 The electrode sheet 10' is shown. Of course, in some other embodiments, the electrode sheet 10 may also have other numbers of electrode units 12. In short, the implementation of the present application is not limited by the number and arrangement of the electrode units 12 of the electrode sheet 10.

[0079] Figure 2 The electrode sheet 10' shown is Figure 1A variation of the electrode sheet 10 shown in the figure, the spatial structure of the electrode sheet 10' is the same as that of the electrode sheet 10, and also includes a plurality of electrode units 12' arranged at intervals, a plurality of connecting portions 111' located between two adjacent electrode units 12', a wiring portion 112' connected to a bridging portion 113', a first cable 13' connected to the wiring portion 112', a first interval D1 formed between the third column electrode unit 12' and the fourth column electrode unit 12', and a second interval D2' formed between adjacent rows of electrode units 12'; the connecting portion 111', the wiring portion 112', and the bridging portion 113' also constitute a flexible circuit board (not numbered), the electrode sheet 10' is also plugged into the adapter 20 through the first plug 41' of the first cable 13' with 10 core wires, and the only difference is that: the two electrode units 12' in the fourth column that are adjacent to each other in the column direction are both disconnected and not connected by the longitudinally arranged connecting portion 111', but the two electrode units 12' in the fifth column that are adjacent to each other in the column direction are connected by the longitudinally arranged connecting portion 111', and each electrode unit 12' in the fourth column is connected to the electrode unit 12' in the fifth column and adjacent to each other in the row direction through the transversely arranged connecting portion 111'; and the bridge portion 113' is connected between the two electrode units 12' in the third row and the third column and the two electrode units 12' in the third row and the fourth column. One trunk 114' is composed of the electrode unit 12' in the third column and the connecting portion 111' between the electrode units 12' in the column, and the other trunk 114' is composed of the electrode unit 12' in the fifth column and the connecting portion 111' between the electrode units 12' in the column. The structure of the left part of the left three columns of the electrode array (not numbered) is similar to Figure 1 The left part of the electrode array (unnumbered) shown in the figure is exactly the same in structure, except that the right part has branches 115' extending from the left and right sides of the corresponding electrode units 12' in the main trunk 114' due to the change of the position of the main trunk 114' from the fourth column to the fifth column.

[0080] Figure 3 for Figure 1 The electrode sheet 10 or the electrode sheet 100 of the first embodiment of the tumor electric field treatment system 100 is shown Figure 2 The circuit connection diagram of the electrode sheet 10' of the modified embodiment and the adapter 20 of the first embodiment is shown. It is worth noting that: Figure 3 The arrangement of the electrode units 12 shown is to more clearly illustrate the electrical connection between an electrode sheet 10 and an adapter 20. Figure 3 The arrangement of the electrode units 12 shown does not represent the arrangement of the electrode units 12 in the spatial structure. The following describes the circuit connection by taking the electrode sheet 10 in the first embodiment as an example.

[0081] Combination Figure 1 as well as Figure 3In this embodiment, each electrode sheet 10 is provided with 20 electrode units 12, and the 20 electrode units 12 are arranged in the order of 1 to 20 in the circuit connection, and are divided into four row groups and five column groups, that is, the 20 electrode units 12 are arranged in four rows and five columns in the circuit connection. The temperature sensor 14 of each electrode unit 12 includes a ground terminal 14-1 and a signal terminal 14-2. The dielectric element 15 and the temperature sensor 14 of each electrode unit 12 are soldered on the flexible circuit board 11, and the dielectric element 15 is short-circuited with the signal terminal 14-2 of the corresponding temperature sensor 14. Since the electrode units 12 are arranged in four rows and five columns in the circuit connection, and each electrode unit includes a corresponding dielectric element 15 and a corresponding temperature sensor 14, the multiple temperature sensors 14 are also arranged in four rows and five columns in the circuit connection, and the multiple dielectric elements 15 are also arranged in four rows and five columns in the circuit connection. It should be noted that the arrangement here is to more clearly show the electrical connection between the electrode sheet 10 and the adapter 20, and does not represent the arrangement of the electrode unit 12 in the spatial structure. Figure 1 The structure shown is generally in the form of an array, but may also be other structures, such as petal-shaped or scattered, and may be regular or irregular. The dielectric element 15 is configured to apply an alternating electric field to the tumor site of the patient. The temperature sensor 14 is configured to detect the temperature of the patient's body surface attached to the electrode sheet 10 and output a temperature detection signal to the adapter 20.

[0082] The flexible circuit board 11 is embedded with multiple conductive traces 171, 172, 18, 19, which include multiple grounding lines 18, multiplexed signal lines 19, one grounding trace 171, and one communication line 172. One end of the grounding trace 171 is connected to the ground pin of the handshake chip 17, and the other end is connected to any one grounding line 18. The grounding pin of the handshake chip 17 is connected to the grounding trace 171, and its communication pin is electrically connected to the communication line 172. That is, the handshake chip 17 is grounded through the grounding line 18 connected to the grounding trace 171, and communicates with an external device through the communication line 172. Specifically, the handshake chip 17 is grounded through a ground trace 171 connected to its ground pin and a ground line 18, and realizes communication connection between it and the electric field generator 30 through the communication line 172 of the flexible circuit board 11, a wire electrically connected to the communication line 172 of the first cable 13, an adapter 20 electrically connected to the first cable 13, and an electric field generator 30 electrically connected to the adapter 20, thereby judging the connection state of the electrode sheet 10. The first cable 13 has a multi-core wire (not shown) electrically connected to the communication line 172, the multi-way ground line 18 and the multi-way dual-purpose signal line 19 of the flexible circuit board 11 in a one-to-one correspondence. The total number of communication lines 172, ground lines 18 and dual-purpose signal lines 19 embedded in the flexible circuit board 11 does not exceed 10. Therefore, the number of wires of the first cable 13 does not exceed 11.

[0083] The number of conductive circuits electrically connected to the ground wire 18 in the tumor electric field therapy system 100 is related to the number of row groups M of the electrode unit 12, which may be greater than or equal to the number of row groups of the electrode unit 12, and M is a positive integer. The number of conductive circuits electrically connected to the dual-purpose signal line 19 in the tumor electric field therapy system 100 is related to the number of column groups N of the electrode unit 12, which may be greater than or equal to the number of column groups of the electrode unit 12, and N is a positive integer. In this embodiment, the number of ground wires 18 is equal to the number of row groups M of the electrode unit 12; the dual-purpose signal line 19 is equal to the number of column groups N of the electrode unit 12. The line L embedded in the flexible circuit board 11 is equal to the sum of the number of ground wires 18 and the number of dual-purpose signal lines 19 plus 2, that is, L=M+N+2. The number of conductors of the first cable 13 is M+N+1.

[0084] The multiplexed signal lines 19 of the flexible circuit board 11 are respectively arranged in one-to-one correspondence with the multiple column groups of the electrode units 12, and are configured to transmit the AC signal generated by the electric field generator 30 to the dielectric elements 15 in each electrode unit 12 in the corresponding column group. That is, the dielectric elements 15 in the same column group are short-circuited through the same dual-purpose signal line 19 of the flexible circuit board 11, and the dielectric elements 15 in different column groups are respectively connected in parallel through different dual-purpose signal lines 19 of the flexible circuit board 11. The dual-purpose signal lines 19 of the flexible circuit board 11 are respectively electrically connected to the corresponding wires in the first cable 13, and then electrically connected to the electric field generator 30 via the adapter 20. That is, the dual-purpose signal lines 19 of the flexible circuit board 11 receive the AC signal generated by the electric field generator 30 through the first cable 13 and the adapter 20.

[0085] The multiple grounding wires 18 are respectively arranged in one-to-one correspondence with the multiple row groups of the electrode units 12, and the multiple grounding wires 18 are respectively used to short-circuit the temperature sensor 14 of each electrode unit 12 corresponding to each row group to the ground. That is, the grounding ends 14-1 of the multiple temperature sensors 14 in the same row group are short-circuited through the same grounding wire 18 of the flexible circuit board 11, and the grounding ends 14-1 of the temperature sensors 14 in different row groups are respectively connected in parallel through different grounding wires 18 of the flexible circuit board 11. During the time period of temperature detection or in the second mode, only one of the multiple grounding wires 18 is turned on at the same time, and the rest are turned off.

[0086] Each of the multiplexed dual-purpose signal lines 19 is also configured to transmit a direct current signal to the temperature sensor 14 in each electrode unit 12 in the corresponding column group to collect and transmit the temperature detection signal obtained by the detection. The signal ends 14-2 of the multiple temperature sensors 14 located in different column groups are respectively connected in parallel through different dual-purpose signal lines 19 of the flexible circuit board 11, and the signal ends 14-2 of the multiple temperature sensors 14 located in the same column group are short-circuited to the same dual-purpose signal line 19 of the flexible circuit board 11, and the short-circuit point serves as a temperature sampling point. Specifically, each dual-purpose signal line 19 is configured to short-circuit the signal end 14-2 of the temperature sensor 14 of at most one electrode unit 12 in each row group to an external device for receiving the detection signal, wherein the signal ends 14-2 of the temperature sensors 14 connected to each of the multiplexed dual-purpose signal lines 19 are different from each other to avoid the dual-purpose signal line 19 from subsequently outputting duplicate signals. That is, when the number of electrode units 12 in a row group is the same as the number of dual-purpose signal lines 19, each dual-purpose signal line 19 is electrically connected to the signal end 14-2 of the temperature sensor 14 of a different electrode unit 12 in the row group; when the number of electrode units 12 in a row group is less than the number of dual-purpose signal lines 19, there is at least one dual-purpose signal line 19 that is not electrically connected to the signal end 14-2 of the temperature sensor 14 of the electrode unit 12, and each of the remaining dual-purpose signal lines 19 is electrically connected to the signal end 14-2 of the temperature sensor 14 of a different electrode unit 12 in the row group. In this embodiment, the external device for receiving the detection signal is an adapter 20. The dual-purpose signal line 19 of the flexible circuit board 11 receives the DC signal from the adapter 20 or the electric field generator 30 through the first cable 13, and transmits the collected or detected temperature signal to the adapter 20, and then transmits it to the electric field generator 30 through the adapter 20.

[0087] In this embodiment, when each electrode unit 12 is equipped with a temperature sensor 14 for temperature detection, the above-mentioned circuit design is used to reduce the number of wires in the first cable 13, thereby avoiding the cable becoming thicker and the cable becoming harder, which increases the difficulty of fixing the cable; at the same time, the increase in the number of wires in the first cable 13 avoids affecting the adhesion effect between the electrode sheet 10 and the body surface corresponding to the tumor site of the patient.

[0088] The grounding wires 18 and dual-purpose signal wires 19 embedded in the flexible circuit board 11 are 9 lines in total. In the present embodiment, the grounding wires 18 embedded in the flexible circuit board 11 are 4 lines, and the dual-purpose signal wires 19 are 5 lines. Specifically, the electrode sheet 10 of the present embodiment includes 4 grounding wires 18, each of which is used to ground the grounding ends 14-1 of the temperature sensors 14 of the same row group. The 4 grounding wires 18 of the electrode sheet 10 are respectively the first grounding wire 18-1, the second grounding wire 18-2, the third grounding wire 18-3 and the fourth grounding wire 18-4. In the 4 row groups of the electrode sheet 10, the first row group includes electrode units 12-1 to 12-5, the second row group includes electrode units 12-6 to 12-10, the third row group includes electrode units 12-11 to 12-15, and the fourth row group includes electrode units 12-16 to 12-20. Specifically, the first grounding wire 18-1 is used to ground the electrode units 12-1 to 12-5 in the first row group; the second grounding wire 18-2 is used to ground the electrode units 12-6 to 12-10 in the second row group; the third grounding wire 18-3 is used to ground the electrode units 12-11 to 12-15 in the third row group; the fourth grounding wire 18-4 is used to ground the electrode units 12-16 to 12-20 in the fourth row group. It should be noted that these grounding wires 18 can be selectively closed or disconnected, which can be achieved by connecting each grounding wire 18 in series with a switch, which will be described in detail below. The above-mentioned "grounding the electrode unit 12" can refer to grounding the ground terminal 14-1 of the temperature sensor 14 in the electrode unit 12, or it can refer to the diode 16 being connected in series with the temperature sensor 14 of the same electrode unit 12 and grounded together. In short, each ground line 18 short-circuits the ground terminals 14 - 1 of the temperature sensors 14 of all the electrode units 12 in the corresponding row group and connects them to ground. The fourth ground line 18 - 4 is also short-circuited with the ground trace 171 connected to the ground pin of the handshake chip 17 .

[0089] Continue to refer Figure 3As shown, the electrode sheet 10 of this embodiment also includes 5 dual-purpose signal lines 19, one end of each dual-purpose signal line 19 is respectively connected to all electrode units 12 in each column group, and the other end thereof is connected to an adapter 20 for receiving temperature detection signals and transmitting AC signals. That is, for each row group, each dual-purpose signal line 19 can choose to connect to one of the electrode units 12 or not connect to any electrode unit 12 in the row group to avoid the dual-purpose signal line 19 from subsequently outputting duplicate signals. Specifically, the 5 dual-purpose signal lines 19 of the electrode sheet 10 include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, a third dual-purpose signal line 19-3, a fourth dual-purpose signal line 19-4, and a fifth dual-purpose signal line 19-5. One end of the first dual-purpose signal line 19-1 is connected to the dielectric elements 15 of the four electrode units 12, namely, electrode unit 12-1, electrode unit 12-6, electrode unit 12-11, and electrode unit 12-16, and the signal end 14-2 of the temperature sensor 14; one end of the second dual-purpose signal line 19-2 is connected to the dielectric elements 15 of the four electrode units 12, namely, electrode unit 12-2, electrode unit 12-7, electrode unit 12-12, and electrode unit 12-17, and the signal end 14-2 of the temperature sensor 14; one end of the third dual-purpose signal line 19-3 is connected to the electrode unit 12-3, electrode unit 12-8, electrode unit 12-1, and electrode unit 12-2. 3. The dielectric elements 15 of the four electrode units 12 of electrode unit 12-18 and the signal end 14-2 of the temperature sensor 14 of the four electrode units 12; one end of the fourth dual-purpose signal line 19-4 is connected to the dielectric elements 15 of the four electrode units 12 of electrode unit 12-4, electrode unit 12-9, electrode unit 12-14, and electrode unit 12-19 and the signal end 14-2 of the temperature sensor 14 of the four electrode units 12; one end of the fifth dual-purpose signal line 19-5 is connected to the dielectric elements 15 of the four electrode units 12 of electrode unit 12-5, electrode unit 12-10, electrode unit 12-15, and electrode unit 12-20 and the signal end 14-2 of the temperature sensor 14. In short, each dual-purpose signal line 19 short-circuits the dielectric elements 15 of the electrode units 12 and the signal end 14-2 of the temperature sensor 14 of the same column group in parallel and is used to connect to an external device. It should be noted that these dual-purpose signal lines 19 can selectively transmit AC signals or receive temperature detection signals. This can be achieved by connecting each dual-purpose signal line 19 in series with a bidirectional switch 26 and coordinating the closing or opening of the grounding line 18, which will be described in detail below.

[0090] In other embodiments, the ground wires 18 and dual-purpose signal wires 19 embedded in the flexible circuit board 11 may have other numbers according to the circuit arrangement and number differences of the electrode units 12 in different electrode sheets, which will be specifically described in subsequent embodiments.

[0091] The ground pin of the handshake chip 17 used by the electrode sheet 10 of this embodiment to confirm its connection status is connected to the fourth ground line 18-4 through a ground trace 171 embedded in the flexible circuit board 11. The first cable 13 has 10 core wires, which are 4 ground lines 18, 5 dual-purpose signal lines 19 and 1 communication line 172. The specific connection relationship and working principle of the handshake chip 17 will be described in detail below.

[0092] The tumor electric field treatment system 100 of this embodiment includes at least one pair of the above-mentioned electrode sheets 10, an adapter 20 electrically connected to the electrode sheets 10, and an electric field generator 30 electrically connected to the adapter 20. The adapter 20 is connected between the electrode sheets 10 and the electric field generator 30. When the electric field generator 30 or the adapter 20 controls the grounding of the ground pin of the handshake chip 17, the electric field generator 30 sends a handshake communication signal to the handshake chip 17 of the electrode sheet 10 via the adapter 20 and the communication line 172 of the electrode sheet 10 to determine the connection status of the electrode sheet 10. When the electrode sheet 10 is connected normally, the electric field generator 30 provides an AC signal to the dielectric element 15 in the multiple electrode units 12 of the electrode sheet 10 via the adapter 20 and the dual-purpose signal line 19 of the electrode sheet 10, or provides a DC signal to the temperature sensor 14 in the multiple electrode units 12 of the electrode sheet 10 via the adapter 20 and the dual-purpose signal line 19 of the electrode sheet 10, and is used to receive the temperature detection signal output by the temperature sensor 14 in the multiple electrode units 12. The adapter 20 is configured to send a handshake communication signal to the communication line 172 of the electrode sheet 10 according to the communication instruction of the electric field generator 30, and is configured to transmit the AC signal generated by the electric field generator 30 to the dual-purpose signal line 19 of the electrode sheet 10, and is also configured to transmit a DC signal to the dual-purpose signal line 19 of the electrode sheet and receive the temperature detection signal output by the multiple dual-purpose signal line 19 of the electrode sheet 10.

[0093] Continue to refer Figure 3 and Figure 4As shown, the adapter 20 includes: a first controller 22, a multi-channel communication transmission line 211 electrically connected to the first controller 22, multiple groups of analog-to-digital converters 23 connected to the first controller 22, multiple groups of pressure resistors 24 and multiple groups of grounding switches 25 corresponding to the multiple groups of analog-to-digital converters 23, multiple groups of two-way switching switches 26 connected to the multiple groups of analog-to-digital converters 23, a first communication unit 27, an AC signal line 28 connected to each group of two-way switching switches 26 in a one-to-one correspondence, and a first power module 29 connected to the first communication unit 27, the first controller 22 and the multiple groups of analog-to-digital converters 23 at the same time, and the first power module 29 provides a DC power supply VCC for each electronic component of the adapter 20. The adapter 20 also includes multiple circuit lines (unnumbered). Among them, the multiple circuit lines (unnumbered) are electrically connected to the multiple grounding lines 18, the multiple dual-purpose signal lines 19, and the communication lines 172 in the flexible circuit board 11 of the corresponding electrode sheet 10 through the first cables 13 of the corresponding electrode sheet 10. The multiple circuit lines (not numbered) include multiple AC signal lines 28 that transmit alternating current signals to the corresponding electrode sheets 10 and are electrically connected to the multiplexed signal lines 19 in the flexible circuit board 11 of the corresponding electrode sheets 10, multiple circuit lines (not numbered) that are electrically connected one-to-one with the multiplexed signal lines 19 in the flexible circuit board 11 of the corresponding electrode sheets 10 and are used to supply power to each temperature sensor 14 of the electrode sheets 10 or transmit the temperature detection signal of the electrode sheets 10, multiple circuit lines (not numbered) that are electrically connected one-to-one with the multiple grounding lines 18 in the flexible circuit board 11 of the corresponding electrode sheets 10, and multiple communication transmission lines 211 that are electrically connected one-to-one with the multiple communication lines 172 in the flexible circuit board 11 of the corresponding electrode sheets 10. The multiple communication transmission lines 211 are all connected to the first controller 22. Each communication transmission line 211 is connected to the communication line 172 of the flexible circuit board 11 through the corresponding first connector 40, and by closing the grounding switch 25 corresponding to a grounding line 18 that short-circuits the grounding pin of the handshake chip 17 of the flexible circuit board 11, the electrical connection between the first controller 22 and the handshake chip 17 can be achieved, so that the handshake chip 17 obtains power and starts the data communication function.

[0094] The number of circuit lines P electrically connected between the adapter 20 and one electrode sheet 10 is equal to the sum of the number of rows M and the number of columns N of the electrode units 12 of the electrode sheet 10 plus 2; the number of circuits H electrically connected between the adapter 20 and X electrode sheets 10 is equal to X times the number of circuit lines electrically connected to a single electrode sheet 10, that is, H=XP=X*(M+N+2). The number of groups of grounding switches 25, the number of groups of bidirectional switching switches 26, the number of AC lines 28, and the number of communication transmission lines 211 are all related to the number of electrode sheets 10. The number of groups of grounding switches 25, the number of groups of bidirectional switching switches 26, the number of AC lines 28, and the number of communication transmission lines 211 are all the same; and are not less than the number of electrode sheets 10. Preferably, the number of groups of grounding switches 25, the number of groups of bidirectional switching switches 26, the number of AC lines 28, and the number of communication transmission lines 211 are all the same as the number of electrode sheets 10. The following is a detailed description of the electrical connection between an electrode sheet 10 with 20 electrode units 12 and the adapter 20 as an example.

[0095] Each group of grounding switches 25 is provided with a plurality of grounding switches 25, which are respectively connected to the adapter 20 and are respectively electrically connected to the circuit lines (not numbered) corresponding to the multi-path grounding lines 18 of the corresponding electrode sheet 10, and are configured to control the conduction or disconnection of the multi-path grounding lines 18. The circuit lines (not numbered) that are electrically connected to the multi-path grounding lines 18 of the electrode sheet 10 are grounded at one end close to the grounding switches 25. The number of grounding switches 25 in each group of grounding switches 25 is related to the number of grounding lines 18 of the flexible circuit board 11 of the corresponding electrode sheet 10, and the two are equal in this embodiment. Figure 3As shown, in this embodiment, each group of grounding switches 25 includes a first grounding switch 25-1, a second grounding switch 25-2, a third grounding switch 25-3 and a fourth grounding switch 25-4. Each group of multiple grounding switches 25 controls the closing or opening of the corresponding grounding line 18 of a corresponding electrode sheet 10 one by one. Specifically, the first grounding switch 25-1 is used to control the closing or disconnection of the first grounding line 18-1 of the corresponding electrode sheet 10, and can cooperate with the corresponding group of two-way switching switches 26 to control the power on and off of each temperature sensor 14 of the five electrode units 12 from electrode unit 12-1 to electrode unit 12-5 in the first row group of the electrode sheet 10; the second grounding switch 25-2 is used to control the closing or disconnection of the second grounding line 18-2 of the electrode sheet 10, and can cooperate with the corresponding group of two-way switching switches 26 to control the power on and off of each temperature sensor 14 of the five electrode units 12 from electrode unit 12-6 to electrode unit 12-10 in the second row group of the electrode sheet 10; the third grounding switch 25-3 is used to control the third grounding line 18-2 of the electrode sheet 10, and can cooperate with the corresponding group of two-way switching switches 26 to control the power on and off of each temperature sensor 14 of the five electrode units 12 from electrode unit 12-6 to electrode unit 12-10 in the second row group of the electrode sheet 10; The closing or disconnection of the ground wire 18-3 can cooperate with the corresponding group of two-way switching switches 26 to control the power on and off of each temperature sensor 14 of the five electrode units 12 from electrode unit 12-11 to electrode unit 12-15 in the third row group of the electrode sheet 10; the fourth grounding switch 25-4 is used to control the closing or disconnection of the fourth grounding wire 18-4 of the electrode sheet 10, and then judge the connection state of the electrode sheet 10 through the electrical connection state of the communication line 172 of the handshake chip 17 and the communication transmission line 211 of the adapter 20, and can also cooperate with the corresponding group of two-way switching switches 26 to control the power on and off of each temperature sensor 14 of the five electrode units 12 from electrode unit 12-16 to electrode unit 12-20 in the fourth row group of the electrode sheet 10. The above-mentioned grounding switch 25 can be a mechanical switch, such as a relay. The grounding switch 25 can also be an electronic switch, and each grounding switch 25 can be opened and closed by the first controller 22 of the adapter 20.

[0096] In this embodiment, the multiple groups of grounding switches 25 are all electronic switches. The first controller 22 is connected to the multiple groups of grounding switches 25 for sequentially and cyclically controlling the opening and closing states of multiple grounding switches 25 in each group of grounding switches 25, and then sequentially and individually conducting each of the multiple grounding wires 18 of the corresponding electrode sheet 10 and cooperating with the switching of the corresponding bidirectional switch 26, so as to sequentially and time-dividedly collect the temperature of the patient's body surface detected by all temperature sensors 14 on the electrode sheet 10. The number of each group of grounding switches 25 is greater than or equal to the number of grounding wires 18 of the flexible circuit board 11 of the corresponding electrode sheet 10. In this embodiment, the number of each group of grounding switches 25 is the same as the number of grounding wires 18 of the corresponding electrode sheet 10.

[0097] Each set of two-way switches 26 is provided with a plurality of two-way switches 26. The plurality of two-way switches 26 in each set are respectively connected to the adapter 20 and are respectively electrically connected to circuit lines (not numbered) corresponding to the multiplex dual-purpose signal lines 19 of the corresponding electrode sheet 10. The number of two-way switches 26 in each set of two-way switches 26 is related to the number of dual-purpose signal lines 19 of the flexible circuit board 11 of the corresponding electrode sheet 10, and is greater than or equal to the number of dual-purpose signal lines 19 of the flexible circuit board 11 of the corresponding electrode sheet 10. Figure 3 In the embodiment shown, the two are equal. Each bidirectional switch 26 has a sampling terminal 1 and an input terminal 2, and the sampling terminals 1 of the multiple bidirectional switches 26 in the same group are respectively electrically connected to the corresponding detection channels in the multiple detection channels of the corresponding group of analog-to-digital converters 23, and each detection channel corresponds to the corresponding temperature sampling point one by one. The input terminal 2 of each bidirectional switch 26 in the same group is electrically connected to the corresponding same AC signal line 28. Each bidirectional switch 26 is configured to control the multiplexer signal line 19 to access the corresponding AC signal line 28 to transmit an alternating current signal or to access the corresponding detection channel of the corresponding group of analog-to-digital converters 23 to receive the temperature detection signal output by the temperature sensor 14.

[0098] like Figure 3 As shown, taking an electrode sheet 10 electrically connected to an adapter 20 as an example, in this embodiment with 20 electrode units 12, the plurality of bidirectional switches 26 are respectively a first bidirectional switch 26-1, a second bidirectional switch 26-2, a third bidirectional switch 26-3, a fourth bidirectional switch 26-4 and a fifth bidirectional switch 26-5. The plurality of bidirectional switches 26 in the same group respectively control the switching of a corresponding one of the multiplexed dual-purpose signal lines 19 of the same electrode sheet 10 between transmitting an alternating current signal and transmitting a temperature detection signal.

[0099] Specifically, the first bidirectional switch 26-1 is used to control the switching of the first dual-purpose signal line 19-1 of the corresponding electrode sheet 10 between transmitting an alternating current signal and transmitting a temperature detection signal, thereby controlling the conduction of each dielectric element 15 of the electrode unit 12-1, electrode unit 12-6, electrode unit 12-11, and electrode unit 12-16 in the first column group of the electrode sheet 10 and the conduction of the signal end 14-2 of each temperature sensor 14 of the electrode unit 12-1, electrode unit 12-6, electrode unit 12-11, and electrode unit 12-16 in the first column group, and cooperating with the corresponding first grounding switch 25-1, second grounding switch 25-2, third grounding switch 25-3, and fourth grounding switch 25-4, so that the first column of electrode units 12-1, electrode unit 12-6, electrode unit 12-11, and electrode unit 12-16 transmit an alternating current signal to the patient or output the temperature collected by the temperature sensors 14 of these electrode units 12 to the corresponding analog-to-digital converter 23. The second bidirectional switch 26-2 is used to control the switching of the second dual-purpose signal line 19-2 of the corresponding electrode sheet 10 between transmitting the alternating current signal and transmitting the temperature detection signal, thereby controlling the conduction of each dielectric element 15 of the electrode unit 12-2, electrode unit 12-7, electrode unit 12-12, and electrode unit 12-17 in the second column group of the electrode sheet 10 and the conduction of the signal end 14-2 of each temperature sensor 14 of the electrode unit 12-2, electrode unit 12-7, electrode unit 12-12, and electrode unit 12-17 in the second column group, and cooperating with the corresponding grounding switch 25-1, grounding switch 25-2, grounding switch 25-3, and grounding switch 25-4, so that the second column of electrode units 12-2, electrode units 12-7, electrode units 12-12, and electrode units 12-17 transmit alternating current signals to the patient or output the temperature detection signals collected by the temperature sensors 14 of these electrode units 12 to the corresponding analog-to-digital converter 23;The third bidirectional switch 26-3 is used to control the switching of the third dual-purpose signal line 19-3 of the corresponding electrode sheet 10 between transmitting an alternating current signal and transmitting a temperature detection signal, thereby controlling the conduction of each dielectric element 15 of the electrode unit 12-3, electrode unit 12-8, electrode unit 12-13, and electrode unit 12-18 in the third column group of the electrode sheet 10 and the conduction of the signal end 14-2 of each temperature sensor 14 of the electrode unit 12-3, electrode unit 12-8, electrode unit 12-13, and electrode unit 12-18 in the third column group, and cooperating with the corresponding first grounding switch 25-1, second grounding switch 25-2, third grounding switch 25-3, and fourth grounding switch 25-4, so that the third column electrode unit 12-3, electrode unit 12-8, electrode unit 12-13, and electrode unit 12-18 transmit an alternating current signal to the patient or output the temperature detection signal collected by the temperature sensor 14 of these electrode units 12 to the corresponding analog-to-digital converter 23. The fourth bidirectional switch 26-4 is used to control the switching of the fourth dual-purpose signal line 19-4 of the corresponding electrode sheet 10 between transmitting an alternating current signal and transmitting a temperature detection signal, thereby controlling the conduction of each dielectric element 15 of the electrode unit 12-4, electrode unit 12-9, electrode unit 12-14, and electrode unit 12-19 in the fourth column group of the electrode sheet 10 and the conduction of the signal end 14-2 of each temperature sensor 14 of the electrode unit 12-4, electrode unit 12-9, electrode unit 12-14, and electrode unit 12-19 in the fourth column group, and cooperating with the corresponding first grounding switch 25-1, second grounding switch 25-2, third grounding switch 25-3, and fourth grounding switch 25-4, so that the fourth column of electrode units 12-4, electrode units 12-9, electrode units 12-14, and electrode units 12-19 transmit alternating current signals to the patient or output the temperature detection signals collected by the temperature sensors 14 of these electrode units 12 to the corresponding analog-to-digital converter 23;The fifth bidirectional switch 26-5 is used to control the switching of the fifth dual-purpose signal line 19-5 of the corresponding electrode sheet 10 between transmitting alternating current signals and transmitting temperature detection signals, thereby controlling the conduction of the dielectric elements 15 of the electrode units 12-5, 12-10, 12-15, and 12-20 in the fifth column group of the electrode sheet 10 and the conduction of the signal ends 14-2 of the temperature sensors 14 of the electrode units 12-5, 12-10, 12-15, and 12-20 in the fifth column group, and cooperating with the corresponding first grounding switch 25-1, second grounding switch 25-2, third grounding switch 25-3, and fourth grounding switch 25-4, so that the fifth column of electrode units 12-5, 12-10, 12-15, and 12-20 transmit alternating current signals to the patient or output the temperature detection signals collected by the temperature sensors 14 of these electrode units 12 to the corresponding analog-to-digital converter 23. ;

[0100] When each group of grounding switches 25 is disconnected and the input end 2 of each group of two-way switching switches 26 is turned on and the sampling end 1 is turned off, an AC signal can be transmitted to the dielectric element 15 of each electrode unit 12 of the corresponding electrode sheet 10. When the sampling end 1 of each group of two-way switching switches 26 is turned on and the input end 2 is turned off, it can cooperate with each grounding switch 25 in the corresponding group of grounding switches 25 to transmit the temperature detection signal collected by the temperature sensor 14 of each electrode unit 12 on the electrode sheet 10 in a time-sharing manner. The above-mentioned two-way switching switch 26 can be a mechanical switch, such as a relay. The two-way switching switch 26 can also be an electronic switch, and the switching of the sampling end 1 and the input end 2 of each two-way switching switch 26 can be controlled by the first controller 22 of the adapter 20.

[0101] In this embodiment, the plurality of sets of two-way switches 26 are all electronic switches. The first controller 22 is in communication connection with the plurality of sets of two-way switches 26, and is used to control the plurality of two-way switches 26 in each set of two-way switches 26 to switch between their respective sampling terminals 1 and input terminals 2, and to coordinate the closing or opening of the corresponding grounding switch 25, so as to continuously monitor the temperature of the patient's body surface detected by all the temperature sensors 14 on the electrode sheet 10 or transmit an AC signal to the patient. In this embodiment, the plurality of sets of grounding switches 25 and the plurality of sets of two-way switches 26 together constitute a switch unit (not numbered).

[0102] In the present embodiment, each group of analog-to-digital converters 23 is electrically connected to the sampling terminals 1 of the plurality of bidirectional switching switches 26 in the corresponding group of bidirectional switching switches 26 through the multi-channel circuit lines (not numbered) in the adapter 20, and is configured to receive the temperature detection signal transmitted by the multiplexed signal line 19 of the corresponding electrode sheet 10, and convert the temperature detection signal from an analog signal to a digital signal. Each group of analog-to-digital converters 23 includes a plurality of detection channels A, B, C, D, and E, and each detection channel A, B, C, D, and E is used to connect a corresponding one-way dual-purpose signal line 19 in the multiplexed signal line 19 through the corresponding bidirectional switching switch 26. The number of detection channels in each group of analog-to-digital converters 23 is related to the number of bidirectional switching switches 26 in the corresponding group. The number of detection channels in each group of analog-to-digital converters 23 is related to the number of column groups of the electrode units 12 of the corresponding electrode sheet 10. Specifically, the number of detection channels in each group of analog-to-digital converters 23 is equal to the number of bidirectional switches 26 in a corresponding group of bidirectional switches 26, which is not less than the number of columns of electrode units 12 of the corresponding electrode sheet 10. Figure 3 As shown, each group of analog-to-digital converters 23 includes a total of 5 detection channels A, B, C, D, and E, which are respectively the first detection channel A, the second detection channel B, the third detection channel C, the fourth detection channel D, and the fifth detection channel E. The first detection channel A is connected to the first dual-purpose signal line 19-1 through the sampling terminal 1 of the first two-way switch 26-1, the second detection channel B is connected to the second dual-purpose signal line 19-2 through the sampling terminal 1 of the second two-way switch 26-2, the third detection channel C is connected to the third dual-purpose signal line 19-3 through the sampling terminal 1 of the third two-way switch 26-3, the fourth detection channel D is connected to the fourth dual-purpose signal line 19-4 through the sampling terminal 1 of the fourth two-way switch 26-4, and the fifth detection channel E is connected to the fifth dual-purpose signal line 19-5 through the sampling terminal 1 of the fifth two-way switch 26-5. Each detection channel A, B, C, D, and E is used to receive the temperature detection signal collected by the temperature sensor 14 of the electrode unit 12 to which the corresponding dual-purpose signal line 19 is connected. In addition, each detection channel A, B, C, D, E is connected to a first power module 29 for providing a detection voltage to the detection channel A, B, C, D, E via a corresponding voltage divider resistor 24 in the adapter 20, and the first power module 29 provides a DC signal.

[0103] In this embodiment, the first communication unit 27 is configured to obtain the digital signals output by the multiple analog-to-digital converters 23 and send the digital signals to the electric field generator 30. The electric field generator 30 is also configured to control and adjust the voltage, current or power of the AC signal provided to the multiple electrode units 12 of the electrode sheet 10 according to the received digital signals. Exemplarily, when any of the multiple digital signals received exceeds the preset threshold value, it means that the temperature of the human body surface to which the corresponding dielectric element 15 is applied detected by at least one temperature sensor 14 in the electrode sheet 10 exceeds the preset threshold temperature (for example, 41°C, 42°C, etc.), and at this time, the voltage, current or power of the AC signal output by the electric field generator 30 can be appropriately reduced to avoid the electrode unit 12 of the electrode sheet 10 from being too high in temperature when the AC signal is applied, causing low-temperature burns to the patient's skin. The above-mentioned preset threshold temperature and preset threshold value can be determined according to the human safety threshold value. The first communication unit 27 is controlled by the first controller 22 and transmits the digital signals converted by the multiple analog-to-digital converters 23 in series. In this embodiment, the preset temperature threshold may be a value within the range of 36°C-45°C.

[0104] One end of each of the multiple communication transmission lines 211 embedded in the adapter 20 is connected to the first controller 22, and the other end is electrically connected to the communication line 172 electrically connected to the communication pin of the handshake chip 17 of the corresponding electrode sheet 10 through the corresponding wire of the corresponding first cable 13. The ground pin GND of the adapter 22 is also connected to the ground pin of the handshake chip 17 of the corresponding electrode sheet 10 through a wire electrically connected to the corresponding ground switch 25 and connected to the wire corresponding to the corresponding first cable 13, a ground wire 18 connected to the corresponding wire of the corresponding first cable 13 and the ground trace 171, and the ground trace 171 short-circuited with the ground wire 18 to achieve connection with the ground pin of the handshake chip 17 of the corresponding electrode sheet 10. That is, the first controller 22 controls a grounding switch 25 corresponding to a grounding line 18-4 that short-circuits the grounding pin of the handshake chip 17 of the electrode sheet 10 to close, and sends a handshake communication signal to the communication line 172 of the electrode sheet 10 through the communication transmission line 211, and determines whether the connection between the electrode sheet 10 and the adapter 20 is normal based on whether the first controller 22 can receive feedback from the communication line 172 of the electrode sheet 10.

[0105] refer to Figure 4 as well as Figure 5 In this embodiment, the first power module 29 is electrically connected to the second power module 31 of the electric field generator 30, and is configured to supply power to the first controller 22, the multiple analog-to-digital converters 23, and the first communication unit 27 of the adapter 20. A first connector 40 is connected between each electrode sheet 10 and the adapter 20, and the first connector 40 is suitable for connecting the corresponding electrode sheet 10 to the adapter 20. Figure 1As shown, the first connector 40 includes a first plug 41 provided at an end of the first cable 13 away from the electrode sheet 10 and a first socket 42 provided on the adapter 20. The first plug 41 and the first socket 42 are push-type spring connectors, that is, the first connector 40 uses a connector to connect the adapter 20 to the electrode sheet 10. Each first cable 13 has five wires electrically connected to the two-way switch 26-1, 26-2, 26-3, 26-4, and 26-5 in the corresponding group of two-way switches 26, four wires electrically connected to the grounding switches 25-1, 25-2, 25-3, and 25-4 in the corresponding group of grounding switches 25, and one wire electrically connected to the communication line 172 of the electrode sheet 10 and the communication transmission line 211 of the adapter 20 at the same time. That is, each first connector 40 is electrically connected one-to-one with a corresponding set of bidirectional switches 26 of the adapter 20, a corresponding set of grounding switches 25, and a corresponding communication transmission line 211 connected to the first controller 22 through 10 wires; and is connected to the electric field generator 30 through a corresponding AC signal line 28 of the adapter 20.

[0106] A second connector 50 is provided between the adapter 20 and the electric field generator 30, and the second connector 50 is suitable for connecting the electric field generator 30 to the adapter 20. The adapter 20 also includes a second cable 21 connected to the second connector 50. The second connector 50 includes a second plug 51 provided at an end of the second cable 21 away from the first controller 22 and a second socket 52 provided on the electric field generator 30. The second plug 51 and the second socket 52 are press-type spring connectors, that is, the second connector 50 connects the adapter 20 and the electric field generator 30 in the form of a connector. Each first connector 40 such as X1, Y1, X2 and Y2 is connected to the second connector 50 through a corresponding AC signal line 28. The first connectors 40 such as X1, Y1, X2 and Y2 are respectively connected to a corresponding set of grounding switches 25, a corresponding set of analog-to-digital converters 23 and a corresponding communication transmission line 211, wherein each first connector 40 is respectively connected to the second connector 50 and the corresponding set of analog-to-digital converters 23 through a corresponding set of two-way switching switches 26. Taking four electrode sheets 10 as an example, the second cable 21 has 8 wires, including 4 wires 1 to 4 that are electrically connected to the corresponding AC signal lines 28 and used to transmit alternating current signals, a wire 5 that is electrically connected to the data receiving line RX of the first communication unit 27, a wire 6 that is electrically connected to the data sending line TX of the first communication unit 27, a wire 7 that is electrically connected to the VCC power line of the first power module 29, and a wire 8 that is electrically connected to the GND line of the first power module 29. The second connector 50 is connected to the first communication unit 27 via a data receiving line RX and a data sending line TX, a VCC pin of the second connector 50 is connected to a VCC power line of the first power module 29, a GND pin of the second connector 50 is connected to a GND line of the first power module 29 and is grounded, and the VCC pin of the second connector 50 is also connected to a corresponding group of voltage dividers 24 and a corresponding group of analog-to-digital converters 23 via a VCC power line of the first power module 29.

[0107] refer to Figure 5The electric field generator 30 includes: a second power module 31, a second controller 32, an AC signal generator 34, a second communication unit 33 and a set of AC signal switches 35. The VCC pin of the second connector 50 is also electrically connected to the VCC power line of the second power module 31, and the GND pin of the second connector 50 is grounded through the GND line of the second power module 31. The second power module 31 is also connected to the second controller 32 and the AC signal generator 34 respectively and supplies power to them. The second communication unit 33 is electrically connected to the wire 5 of the second connector 50 through its data receiving line RX and is electrically connected to the wire 6 of the second connector 50 through its data sending line TX, thereby realizing information interaction between the electric field generator 30 and the adapter 20. The second controller 32 is also electrically connected to the second communication unit 33, the AC signal generator 34 and a group of AC signal switches 35. The second controller 32 is configured to control the opening and closing of each AC signal switch 35 in a group of AC signal switches 35 and adjust the relevant parameters of the AC signal applied by the AC signal generator 34 according to the relevant digital signal received by the second communication unit 33 from the adapter 20. The relevant parameters of the AC signal include the voltage, current and power of the AC signal. The AC signal generator 34 is electrically connected to a plurality of wires 1, 2, 3, and 4 for transmitting AC signals in the second connector 50 through a group of AC signal switches 35. A group of AC signal switches 35 includes a plurality of AC signal switches 35, and the plurality of AC signal switches 35 are arranged one by one with a plurality of electrode sheets 10. Each AC signal switch 35 is electrically connected to a corresponding wire 1, 2, 3, and 4 for transmitting AC signals in the second connector 50 through an AC signal connection 36 and is electrically connected to the corresponding electrode sheet 10 through the corresponding wires 1, 2, 3, and 4 of the second connector 50, so as to transmit AC signals to each electrode sheet 10. The AC signal generator 34 is electrically connected to the group of AC signal switches 35 through a group of AC signal wirings 36 .

[0108] Specifically, the number of AC signal switches 35 of the electric field generator 30 is related to the number of electrode sheets 10. In this embodiment, the number of AC signal switches 35 is equal to the number of electrode sheets 10 and both are 4. The AC signal switch 35 includes a first AC signal switch 35-1, a second AC signal switch 35-2, a third AC signal switch 35-3, and a fourth AC signal switch 35-4, which are electrically connected to the wires 1 to 4 of the second connector 50 in a one-to-one correspondence.One end of the first AC signal switch 35-1 is electrically connected to the AC signal generator 34 through the first AC signal connection 36 of the electric field generator 30, and the other end is electrically connected to the corresponding wire 1 for transmitting AC signals in the second connector 50 through the first AC signal connection 36-1 and is electrically connected to the AC signal line 28 at the port X1 of the adapter 20 through the wire 1 of the second connector 50, the AC signal line 28 at the port X1 of the adapter 20 is electrically connected to the first connector 40, and the first connector 40 at the port X1 of the adapter 20 is electrically connected to the corresponding electrode sheet 10, so as to control whether the AC signal generator 34 transmits an AC signal to the electrode sheet 10 electrically connected to the port X1 of the adapter 20; the first One end of the second AC signal switch 35-2 is electrically connected to the AC signal generator 34 through the second AC signal connection 36 of the electric field generator 30, and the other end is electrically connected to the corresponding wire 2 for transmitting AC signals in the second connector 50 through the second AC signal connection 36-2 and electrically connected to the AC signal line 28 at the port Y1 of the adapter 20 through the wire 2 of the second connector 50, the AC signal line 28 at the port Y1 of the adapter 20 is electrically connected to the first connector 40, and the first connector 40 at the port Y1 of the adapter 20 is electrically connected to the corresponding electrode sheet 10, so as to control whether the AC signal generator 34 transmits AC signals to the electrode sheet 10 electrically connected to the port Y1 of the adapter 20; the first One end of the third AC signal switch 35-3 is electrically connected to the AC signal generator 34 through the third AC signal connection 36-3 of the electric field generator 30, and the other end is electrically connected to the corresponding wire 3 for transmitting AC signals in the second connector 50 through the AC signal connection 36-3 and electrically connected to the AC signal line 28 at the port X2 of the adapter 20 through the wire 3 of the second connector 50, the AC signal line 28 at the port X2 of the adapter 20 is electrically connected to the first connector 40, and the first connector 40 at the port X2 of the adapter 20 is electrically connected to the corresponding electrode sheet 10, so as to control whether the AC signal generator 34 transmits AC signals to the electrode sheet 10 electrically connected to the port X2 of the adapter 20; the fourth One end of the AC signal switch 35-4 is electrically connected to the AC signal generator 34 through the fourth AC signal connection 36-4 of the electric field generator 30, and the other end is electrically connected to the corresponding conductor 4 for transmitting AC signals in the second connector 50 through the fourth AC signal connection 36-4 and electrically connected to the AC signal line 28 at the port Y2 of the adapter 20 through the conductor 4 of the second connector 50, the AC signal line 28 at the port Y2 of the adapter 20 is electrically connected to the first connector 40, and the first connector 40 at the port Y2 of the adapter 20 is electrically connected to the corresponding electrode sheet 10, so as to control whether the AC signal generator 34 transmits AC signals to the electrode sheet 10 electrically connected to the port Y1 of the adapter 20.

[0109] The working principle of the handshake chip 17 is described in detail as follows. The handshake chip 17 can store electrical energy through an external energy storage element (not shown) when the communication line 172 transmits a high level, and release energy when the communication line 172 transmits a low level, so that the handshake chip 17 obtains sufficient power and works normally. Optionally, the energy storage element is a capacitor. In this way, the handshake chip 17 only needs an additional core wire for communication to work normally. The handshake chip 17 is suitable for handshake communication with an external device such as an electric field generator 30 or an adapter 20 to determine the connection status of each pair of electrode sheets 10, wherein, after the handshake chip 17 completes the handshake communication with the adapter 20 and / or the electric field generator 30, by combining the configuration of the state of the bidirectional switching switch 26 and the grounding switch 25, the electrode sheet 10 can apply an AC signal or perform temperature acquisition. When the electrode sheet 10 needs to collect or measure temperature, all the two-way switches 26 on the flexible circuit board 11 of the electrode sheet 10 are located at the sampling end 1, and the electric field generator 30 or the adapter 20 can close each grounding switch 25 in sequence, so that the analog temperature signal of the corresponding temperature sensor 14 in each row group is sampled at the same time by the corresponding temperature sampling point. The analog temperature signal detected by each sampled temperature sensor 14 can also be converted into a type that can characterize the electrode sheet 10 if the electrode sheet 10 is qualified, and can also be used to characterize whether the electrode sheet 10 has temperature abnormality.

[0110] Specifically, when receiving the handshake signal sent by the electric field generator 30, the first controller 22 of the adapter 20 controls the corresponding grounding switch 25 connected to the grounding pin of the handshake chip 17 to close, so that the handshake chip 17 is powered on and works, and the handshake signal is sent to the handshake chip 17. The handshake chip 17 sends a feedback signal, and the first controller 22 on the adapter 20 sends the feedback signal of the handshake chip 17 to the second controller 32 of the electric field generator 30 through the second connector 50. The second controller 32 determines whether the corresponding first controller 22 and the handshake chip 17 have completed the handshake communication according to the feedback signal of the handshake chip 17, and after the handshake communication is completed, the state of each grounding switch 25 and each bidirectional switch 26 in the switch unit (unnumbered) on the adapter 20 is configured to transmit an AC signal to the dielectric element of each electrode unit 12 of the electrode sheet 10 or measure the temperature through the temperature sensor 14 of each electrode unit 12 of the electrode sheet 10. When the electrode sheet 10 is in the temperature collection state, the electric field generator 30 controls each bidirectional switch 26 of the adapter 20 through its second controller 32 so that each bidirectional switch 26 is at its own collection end 1, and closes each grounding switch 25 in sequence, so that each detection channel of the corresponding analog-to-digital converter 23 collects the temperature detection signal of each temperature sensor 14 in a row, and performs analog-to-digital conversion on the obtained temperature analog signals to obtain a number of AD sampling values, and the AD sampling values ​​correspond to digital temperature. The first controller 22 can also send a number of AD sampling values ​​to the electric field generator 30 through the adapter 20, so that if the electrode sheet 10 is qualified, the electric field generator 30 identifies the type of the corresponding electrode sheet 10 according to the number of AD sampling values, and / or, in the process of transmitting the alternating electric signal to the corresponding electrode sheet 10, determines whether the temperature of the corresponding electrode sheet 10 is abnormal according to the number of AD sampling values.

[0111] The following will refer to Figures 3 to 5 The working principle of the tumor electric field treatment system 100 of this embodiment is described in detail.

[0112] The second controller 32 of the electric field generator 30 controls the grounding switch 25-4 corresponding to the fourth grounding line 18-4 connected to the handshake chip 17 of the electrode sheet 10 to be in a closed state through the first controller 22 of the adapter 20, and sends a handshake signal to the communication line 172 of the electrode sheet 10 through the first controller 22, and judges the connection state between the electrode sheet 10 and the adapter 20 according to whether the feedback of the handshake chip 17 can be received. If the electric field generator 30 can receive the feedback signal from the electrode sheet 10, it means that the connection between the electrode sheet 10 and the adapter 20 is normal; then an alternating current signal can be applied to the electrode sheet 10 or a temperature detection signal can be collected through the temperature sensor 14 of the electrode sheet 10. If the electric field generator 30 does not receive the feedback signal from the electrode sheet 10, it means that the connection between the electrode sheet 10 and the adapter 20 is abnormal, and the second controller 32 of the electric field generator 30 issues a connection abnormality prompt to remind the operator. After the operator handles the process, the second controller 32 continues to control the first controller 22 of the adapter 20 to send a handshake communication signal to the handshake chip 17 of the electrode sheet 10, and repeats the above-mentioned operation of judging the connection status of the electrode sheet 10 until the electrode sheet 10 and the adapter 20 are connected normally.

[0113] When the electrode sheet 10 is connected normally and the temperature of each electrode unit 12 of a certain electrode sheet 10 needs to be detected, the first controller 22 of the adapter 20 or the second controller 32 of the electric field generator 30 controls the sampling end 1 of each of the multiple bidirectional switching switches 26 of a group of bidirectional switching switches 26 electrically connected to the electrode sheet 10 to be turned on and the input end 2 to be turned off, so as to disconnect the AC signal applied to the electrode sheet 10; at the same time, the first controller 22 of the adapter 20 or the second controller 32 of the electric field generator 30 controls each of the grounding switches 25 in a group of grounding switches 25 electrically connected to the electrode sheet 10 to be turned on in sequence in a time-sharing manner. At this time, the temperature detection signals collected by each temperature sensor 14 of each electrode unit 12 of each row group of the electrode sheet 10 can be collected in a time-sharing manner in sequence through multiple detection channels A, B, C, D, and E of a group of analog-to-digital converters 23 corresponding to the electrode sheet 10. Each detection channel A, B, C, D, E of each group of analog-to-digital converters 23 only collects the temperature detection signal of the temperature sensor 14 of the corresponding electrode unit 12 in each electrode unit 12 of the electrode sheet 10 in the same row group at the same time, and the above temperature detection signal can be represented by a voltage value. Among the four grounding switches 25 in a group of grounding switches 25 corresponding to the electrode sheet 10, only one grounding switch 25 can be turned on at the same time, and the other three are turned off. The five bidirectional switching switches 26 of a group of bidirectional switching switches 26 corresponding to the group of analog-to-digital converters 23 are all switched to their respective sampling terminals 1 so that each dual-purpose signal line 19 of the electrode sheet 10 is electrically connected to the corresponding detection channel A, B, C, D, E of the corresponding analog-to-digital converter 23 in a one-to-one correspondence and turned on. In this way, the group of analog-to-digital converters 23 can collect the voltage values ​​of all temperature sensors 14 of each electrode unit 12 in the same row group that is short-circuited with one grounding line 18 corresponding to the turned-on grounding switch 25.

[0114] Specifically, when the first grounding switch 25-1 is closed, the second grounding switch 25-2, the third grounding switch 25-3 and the fourth grounding switch 25-4 are all opened, and the first two-way switch 26-1, the second two-way switch 26-2, the third two-way switch 26-3, the fourth two-way switch 26-4 and the fifth two-way switch 26-5 are all switched to their respective sampling terminals 1, the temperature sensors 14 of the electrode units 12-1 to 12-5 of the first row group are powered on, and the temperature sensors 14 of the electrode units 12-6 to 12-20 of the remaining row groups are powered off, and the electrode units 12-1, 12-6, 12-11 and 12-16 are short-circuited on the first detection channel A of the group of analog-to-digital converters 23. Since only the grounding terminal 14-1 of the temperature sensor 14 of the electrode unit 12-1 is connected to the ground, and the grounding terminals 14-1 of the temperature sensors 14 of the electrode units 12-6, 12-11, and 12-16 are disconnected, and each electrode unit 12 is provided with a diode 16 connected in series with the temperature sensor 14, the remaining temperature sensors 14 located in the first row will not affect the resistance value of the temperature sensor 14 of the electrode unit 12-1. Therefore, only the temperature sensor 14 of the electrode unit 12-1 is effectively operated on the first detection channel A of the group of analog-to-digital converters 23, and the temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature sensor 14 of the electrode unit 12-1. Similarly, the voltage value collected on the second detection channel B in the group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-2. The voltage value collected on the third detection channel C in the group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-3. The voltage value collected on the fourth detection channel D in the set of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-4. The voltage value collected on the fifth detection channel E in the analog-to-digital converter 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-5.

[0115] When the second grounding switch 25-2 is closed, the first grounding switch 25-1, the third grounding switch 25-3 and the fourth grounding switch 25-4 are all opened, and the first two-way switch 26-1, the second two-way switch 26-2, the third two-way switch 26-3, the fourth two-way switch 26-4 and the fifth two-way switch 26-5 are all switched to their respective sampling terminals 1, the temperature sensors 14 of the electrode units 12-6 to 12-10 of the second row group are powered on, and the temperature sensors 14 of the electrode units 12-1 to 12-5 and the electrode units 12-11 to 12-20 of the remaining row groups are powered off, and the electrode units 12-1, 12-6, 12-11 and 12-20 of the first detection channel A in the group of analog-to-digital converters 23 are short-circuited. Since only the grounding terminal 14-1 of the temperature sensor 14 of the electrode unit 12-6 is connected to the ground, and the grounding terminals 14-1 of the temperature sensors 14 of the electrode units 12-1, 12-11, and 12-16 are disconnected, and each electrode unit 12 is provided with a diode 16 connected in series with the temperature sensor 14, the remaining temperature sensors 14 located in the second row will not affect the resistance value of the temperature sensor 14 of the electrode unit 12-6. Therefore, only the temperature sensor 14 of the electrode unit 12-6 is effectively operated on the first detection channel A of the group of analog-to-digital converters 23. At this time, the temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature sensor 14 of the electrode unit 12-6. Similarly, the voltage value collected on the second detection channel B in the group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-7. The voltage value collected on the third detection channel C in the group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-8. The voltage value collected on the fourth detection channel D in the group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-9. The voltage value collected on the fifth detection channel E in the group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-10.

[0116] When the third grounding switch 25-3 is closed, the first grounding switch 25-1, the second grounding switch 25-2 and the fourth grounding switch 25-4 are all opened, and the first two-way switch 26-1, the second two-way switch 26-2, the third two-way switch 26-3, the fourth two-way switch 26-4 and the fifth two-way switch 26-5 are all switched to their respective sampling terminals 1, the temperature sensors 14 of the electrode units 12-11 to 12-15 of the third row group are powered on, and the temperature sensors 14 of the electrode units 12-1 to 12-10 and the electrode units 12-16 to 12-20 of the remaining row groups are powered off, and the electrode units 12-1, 12-6, 12-11, 12-20 on the first detection channel A of the group of analog-to-digital converters 23 are short-circuited. As for the signal end 14-2 of the temperature sensor 14 of each of the electrode unit 12-16, since only the ground end 14-1 of the temperature sensor 14 of the electrode unit 12-11 is connected to the ground, and the ground ends 14-1 of the temperature sensors 14 of the electrode unit 12-1, the electrode unit 12-6, and the electrode unit 12-16 are disconnected, and each electrode unit 12 is provided with a diode 16 connected in series with the temperature sensor 14, the remaining temperature sensors 14 located in the third row will not affect the resistance value of the temperature sensor 14 of the electrode unit 12-11, so only the temperature sensor 14 of the electrode unit 12-11 is effectively operated on the first detection channel A of the group of analog-to-digital converters 23, at this time, the temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature sensor 14 of the electrode unit 12-11. Similarly, the voltage value collected on the second detection channel B in the group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-12. The voltage value collected on the third detection channel C in the group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-13. The voltage value collected on the fourth detection channel D in the group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-14. The voltage value collected on the fifth detection channel E in the group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-15.

[0117] When the fourth grounding switch 25-4 is closed, the first grounding switch 25-1, the second grounding switch 25-2 and the third grounding switch 25-3 are all opened, and the first two-way switch 26-1, the second two-way switch 26-2, the third two-way switch 26-3, the fourth two-way switch 26-4 and the fifth two-way switch 26-5 are all switched to their respective sampling terminals 1, the temperature sensors 14 of the electrode units 12-16 to 12-20 of the fourth row group are powered on, and the temperature sensors 14 of the electrode units 12-1 to 12-15 of the remaining row groups are powered off, and the temperature sensors 14 of the electrode units 12-1 to 12-15 of the first detection channel A in the group of analog-to-digital converters 23 are short-circuited. The signal end 14-2 of the sensor 14 is connected to the ground because only the ground end 14-1 of the temperature sensor 14 of the electrode unit 12-16 is connected to the ground, and the ground ends 14-1 of the temperature sensors 14 of the electrode units 12-1, 12-6, and 12-11 are disconnected, and each electrode unit 12 is provided with a diode 16 connected in series with the temperature sensor 14, and the remaining temperature sensors 14 located in the fourth row will not affect the resistance value of the temperature sensor 14 of the electrode unit 12-16. Therefore, only the temperature sensor 14 of the electrode unit 12-16 is effectively operated on the first detection channel A of the group of analog-to-digital converters 23. At this time, the temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature sensor 14 of the electrode unit 12-16. Similarly, the voltage value collected on the second detection channel B in the group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-17. The voltage value collected on the third detection channel C in the group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-18. The voltage value collected on the fourth detection channel D in the group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-19. The voltage value collected on the fifth detection channel E in the group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-20. Thus, the first controller 22 of the adapter 20 or the second controller 32 of the electric field generator 30 can collect the temperature detection signals of the temperature sensors 14 of all the electrode units 12 of a certain electrode sheet 10 by controlling a group of bidirectional switching switches 26 and a group of grounding switches 25 that are electrically connected to the electrode sheet 10. Similarly, the temperature detection signals of the temperature sensors 14 of each electrode unit 12 of other electrode sheets 10 can be obtained.

[0118] The first controller 22, the plurality of analog-to-digital converters 23, and the plurality of bidirectional switches 26 can automatically perform operations through pre-programmed program codes. For example, the first controller 22 first controls all the bidirectional switches 26 in the corresponding group of bidirectional switches 26 to switch to the sampling end 1 so that the sampling ends 1 of the bidirectional switches 26 are all turned on and the input ends 2 are all turned off so that the dual-purpose signal lines 19 of the corresponding electrode sheet 10 are electrically connected to the corresponding group of analog-to-digital converters 23, and then closes the first grounding switch 25-1 in the corresponding group of grounding switches 25, and disconnects the remaining second grounding switches 25-2, third grounding switches 25-3 to fourth grounding switches 25-4 in the group of grounding switches 25. During this period, the group Each detection channel A, B, C, D, E of the analog-to-digital converter 23 obtains the temperature detection signal of each temperature sensor 14 of each electrode unit 12 located in the first row group in the corresponding electrode sheet 10 and converts it into a digital signal and stores it in a separately set memory. Then, after a preset interval, the first controller 22 closes the second grounding switch 25-2 in the group of grounding switches 25 and disconnects the first grounding switch 25-1, the third grounding switch 25-3 and the fourth grounding switch 25-4 in the group of grounding switches 25. During this period, each detection channel A, B, C, D, E of the group of analog-to-digital converters 23 obtains the temperature detection signal of each temperature sensor 14 of each electrode unit 12 located in the second row group. In this way, each grounding switch 25 in the group of grounding switches 25 is turned on separately in turn, and the temperature detection signal of all the temperature sensors 14 in each row group of the electrode sheet 10 can be obtained. Similarly, the temperature detection signal of all the temperature sensors 14 on at least one pair of electrode sheets 10 is obtained through this operation.

[0119] The tumor electric field therapy system 100 of the present application can realize real-time and comprehensive monitoring of the temperature of all electrode units 12 on the electrode sheet 10 without increasing the weight of the electrode sheet 10 or the core of the first cable 13 electrically connected to the electrode sheet 10, and then determine whether the electrode sheet 10 is qualified based on the obtained temperature detection signal; or determine whether the temperature sensor 14 of the electrode sheet 10 is faulty or abnormal based on the obtained temperature detection signal, and determine whether the electrode sheet 10 needs to be replaced based on the number of faulty or abnormal temperature sensors 14 obtained; or if the electrode sheet is qualified, identify the type of the electrode sheet based on the obtained temperature detection signal; or if the electrode sheet is qualified, determine whether the electrode unit 12 of the electrode sheet 10 is over-temperature based on the obtained temperature detection signal, and then control the alternating electric signal applied to the electrode sheet 10 or the electrode unit 12 of the corresponding column of the electrode sheet 10, so as to avoid low-temperature burns on the patient's body surface when the electrode sheet 10 is used for tumor treatment. In addition, the flexible circuit board 11 of the electrode sheet 10 of the present application is electrically connected to the dielectric element 15 of the same electrode unit 12 and the signal end 14-2 of the temperature sensor 14 through the same dual-purpose signal line 19. While it can transmit both AC signals and DC signals for temperature signal collection and collected temperature detection signals through the dual-purpose signal line 19, it also greatly reduces the number of conductive traces (grounding line 18, dual-purpose signal line 19) arranged thereon, reduces the wiring difficulty of the flexible circuit board 11, simplifies the manufacturing process, reduces the weight of the flexible circuit board 11, and reduces the manufacturing cost. The electrode sheet 10 of the present application can also switch between applying AC signals for tumor treatment and transmitting DC signals for temperature collection and transmitting collected temperature detection signals through the combined control of the grounding switch 25 electrically connected to the grounding line 18 arranged thereon and the bidirectional switching switch 26 electrically connected to the dual-purpose signal line 19.

[0120] When the electrode sheet 10 is connected normally and an alternating current signal needs to be applied to the patient through each electrode unit 12 of a certain electrode sheet 10, the first controller 22 of the adapter 20 or the second controller 32 of the electric field generator 30 controls all the grounding switches 25 in a group of grounding switches 25 corresponding to the electrode sheet 10 to be disconnected, and at the same time controls all the bidirectional switching switches 26 in a group of bidirectional switching switches 26 corresponding to the electrode sheet 10 to be switched to their respective input terminals 2, so that the sampling terminals 1 of the bidirectional switching switches 26 are all disconnected and the input terminals 2 are all turned on, so that all the dual-purpose signal lines 19 of the electrode sheet 10 are electrically connected to an AC signal line 28 corresponding to the adapter 20 and the electrode sheet 10, thereby transmitting the alternating current signal to each electrode unit 12 of the electrode sheet 10.When the temperature detection signals of the temperature sensors 14 of all the electrode units 12 of the electrode sheet 10 are far lower than the preset temperature threshold stored in the electric field generator 30 or the adapter 20, the electric field generator 30 controls the AC signal generator 34 through its second controller 32 to continue to generate an AC signal with an increased voltage or current amplitude or a constant voltage or current amplitude, and then transmits it to the corresponding pair of electrode sheets 10 through a corresponding AC signal line 28 of the adapter 20, so that the pair of electrode sheets 10 continue to apply the AC signal; when the temperature detection signals of the temperature sensors 14 of all the electrode units 12 of the electrode sheet 10 are lower than but close to the preset temperature threshold stored in the electric field generator 30 or the adapter 20, The electric field generator 30 can reduce the voltage or current of the alternating current signal generated by the AC signal generator 34 through the second controller 32, thereby reducing the voltage or current of the alternating current signal applied to the pair of electrode sheets 10; when it is detected that the temperature detection signal of the temperature sensor 14 of an electrode unit 12 in a certain electrode sheet 10 is greater than a preset temperature threshold, the electric field generator 30 controls the AC signal switch 35 electrically connected to the electrode sheet 10 to disconnect through the second controller 32 to stop applying the alternating current signal to the electrode sheet 10; or the second controller 32 of the electric field generator 30 or the first controller 22 of the adapter 20 controls all the bidirectional switches in a group of bidirectional switches 26 electrically connected to the electrode sheet 10 The switches 26 are all switched from their input terminals 2 to the sampling terminals 1, that is, all the sampling terminals 1 of a group of bidirectional switching switches 26 electrically connected to the electrode sheet 10 are controlled to be turned on and all the input terminals 2 are turned off, thereby stopping the application of the alternating electric signal to the electrode sheet 10 for a time limit; or, when it is detected that the temperature detection signal of the temperature sensor 14 of an electrode unit 12 of a certain electrode sheet 10 is greater than a preset temperature threshold, the second controller 32 of the electric field generator 30 controls the AC signal switch 35 electrically connected to the electrode sheet 10 to continue to be turned on, and the second controller 32 of the electric field generator 30 or the first controller 22 of the adapter 20 controls a bidirectional switch 14 electrically connected to the electrode unit 12 of the electrode sheet 10 to be turned on. The switch 26 is switched from its input end 2 to its sampling end 1, and the second controller 32 of the electric field generator 30 or the first controller 22 of the adapter 20 simultaneously controls the input ends 2 of the remaining bidirectional switches 26 electrically connected to the electrode units 12 of the electrode sheet 10 whose temperature detection signals do not exceed the preset temperature threshold and are in different columns from the electrode units 12 whose temperature detection signals exceed the preset temperature threshold to continue to maintain electrical connection, so as to stop applying the AC signal to all the electrode units 12 in the column where the electrode units 12 whose temperature detection signals of the electrode sheet 10 exceed the preset temperature threshold are located, and continue to apply the AC signal to the electrode units 12 in the remaining columns whose temperature detection signals of the electrode sheet 10 do not exceed the preset temperature threshold. In this way, the control method of applying the AC signal of the temperature detection signal to different regions of the tumor electric field treatment system 100 is realized.When an AC signal is applied, all grounding switches 25 are opened.

[0121] In the embodiment of the present application, the grounding switch 25 electrically connected to the multi-way grounding wires 18 of the electrode sheet 10 and the bidirectional switch 26 electrically connected to the multi-way dual-purpose signal wires 19 of the electrode sheet 10 are both provided in the adapter 20. However, in other embodiments, the grounding switch 25 electrically connected to the grounding wire 18 and the bidirectional switch 26 electrically connected to the dual-purpose signal wire 19 can also be provided on the electrode sheet 10 or provided in the electric field generator 30, which will not be described in detail here. In addition, the analog-to-digital converter 23 provided in the adapter 20 can also be provided in the electric field generator 30 and directly controlled by the second controller 32.

[0122] The present application also provides other embodiments of the electrode sheet 10 , and the differences among the multiple embodiments are mainly the different numbers of electrode units 12 and / or the different circuit distribution modes of the electrode units 12 , which will be described below respectively.

[0123] Figure 6 FIG. 1 is a circuit connection diagram of a tumor electric field treatment system according to a second embodiment of the present application, showing the electrode sheet 10D and the Figure 1 The circuit connection diagram of the adapter 20 of the first embodiment shown in . The following circuit description is made by taking the electrode sheet 10D in the second embodiment as an example. In terms of electrical connection, the difference between the electrode sheet 10D and the electrode sheet 10 of the first embodiment lies in the number of electrode units 12 and the circuit arrangement. The electrode sheet 10D in this embodiment has 13 aforementioned electrode units 12. In terms of electrical connection, the flexible circuit board 11D of the electrode sheet 10D arranges these 13 electrode units 12 into three rows and five columns on the circuit, wherein each of the two rows has 5 electrode units 12, and the remaining row has 3 electrode units 12. The flexible circuit board 11D of the electrode sheet 10D is embedded with 3 grounding wires 18, 5 dual-purpose signal wires 19, 1 grounding trace 171 connected to the ground pin of the handshake chip 17 and any grounding wire 28 at the same time, and 1 communication wire 172 connected to the communication pin of the handshake chip 17. Each grounding line 18 is used to ground the grounding terminal 14-1 of the temperature sensor 14 of each electrode unit 12 in a corresponding row group, and each dual-purpose signal line 19 short-circuits the dielectric element 15 of each electrode unit 12 in each column group and the signal terminal 14-2 of each temperature sensor 14, so as to receive a temperature detection signal or transmit an AC signal. The grounding line 18 connected to the grounding trace 171 also grounds the ground pin of the handshake chip 17.

[0124] The three grounding wires 18 of the flexible circuit board 11D are respectively a first grounding wire 18-1, a second grounding wire 18-2 and a third grounding wire 18-3. In the three row groups of the electrode sheet 10D, the first row group includes electrode units 12-1 to 12-5, the second row group includes electrode units 12-6 to 12-10, and the third row group includes electrode units 12-11 to 12-13. Specifically, the first grounding line 18-1 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of the electrode units 12-1 to 12-5 in the first row group; the second grounding line 18-2 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of the electrode units 12-6 to 12-10 in the second row group; the third grounding line 18-3 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of the electrode units 12-11 to 12-13 in the third row group and is also used to ground the ground pin of the handshake chip 17 through the grounding trace 171 connected to the ground pin of the handshake chip 17. In short, each grounding line 18 short-circuits the grounding terminals 14-1 of the temperature sensors 14 of all the electrode units 12 in the corresponding row group and grounds them, and one of the grounding lines 18 also short-circuits the ground pin of the handshake chip 17 to ground.

[0125] The five dual-purpose signal lines 19 of the electrode sheet 10D include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, a third dual-purpose signal line 19-3, a fourth dual-purpose signal line 19-4, and a fifth dual-purpose signal line 19-5. One end of the first dual-purpose signal line 19-1 is connected to the dielectric elements 15 of the three electrode units 12, the electrode unit 12-1, the electrode unit 12-6, and the electrode unit 12-11, and the signal end 14-2 of the temperature sensor 14; one end of the second dual-purpose signal line 19-2 is connected to the dielectric elements 15 of the three electrode units 12, the electrode unit 12-2, the electrode unit 12-7, and the electrode unit 12-12, and the signal end 14-2 of the temperature sensor 14; one end of the third dual-purpose signal line 19-3 is connected to the electrode unit 12-3, the electrode unit 12-6, and the electrode unit 12-11, and the signal end 14-2 of the temperature sensor 14 The fourth dual-purpose signal line 19-4 is connected to the dielectric elements 15 of the three electrode units 12, electrode unit 12-8, and electrode unit 12-13, and the signal end 14-2 of the temperature sensor 14; one end of the fourth dual-purpose signal line 19-4 is connected to the dielectric elements 15 of the two electrode units 12, electrode unit 12-4 and electrode unit 12-9, and the signal end 14-2 of the temperature sensor 14; one end of the fifth dual-purpose signal line 19-5 is connected to the dielectric elements 15 of the two electrode units 12, electrode unit 12-5 and electrode unit 12-10, and the signal end 14-2 of the temperature sensor 14. In short, each dual-purpose signal line 19 short-circuits the dielectric elements 15 of each electrode unit 12 and the signal end 14-2 of the temperature sensor 14 in parallel in a corresponding column group and is used to connect to the adapter 20.

[0126] The first grounding switch 25-1, the second grounding switch 25-2 and the third grounding switch 25-3 on the adapter 20 are electrically connected to the first grounding line 18-1, the second grounding line 18-2 and the third grounding line 18-3 of the electrode sheet 10D through the first connector 40D, and the fourth grounding switch 25-4 is in an idle disconnected state. The first two-way switch 26-1, the second two-way switch 26-2, the third two-way switch 26-3, the fourth two-way switch 26-4 and the fifth two-way switch 26-5 on the adapter 20 are electrically connected to the first two-purpose signal line 19-1, the second two-purpose signal line 19-2, the third two-purpose signal line 19-3, the fourth two-purpose signal line 19-4 and the fifth two-purpose signal line 19-5 of the electrode sheet 10D through the first connector 40D. A communication transmission line 211 on the adapter 20 is electrically connected to the communication line 172 connected to the communication pin of the handshake chip 17 of the electrode sheet 10D.

[0127] The working mode of the tumor electric field therapy system formed by the electrode sheet 10D, the adapter 20 and the electric field generator 30 is the same as the aforementioned tumor electric field therapy system 100. The second controller 32 of the electric field generator 30 sends a handshake communication signal to the first controller 22 of the adapter 20, and through the first controller 22 of the adapter 20 or directly controlling the third grounding switch 25-3 electrically connected to the handshake chip 17 of the electrode sheet 10 is closed, and the handshake chip 17 is powered on. At this time, the first controller 22 sends a handshake communication signal to the handshake chip, and confirms that the electrode sheet 10 is connected normally after receiving the feedback signal of the handshake chip 17, and confirms that the electrode sheet 10 is abnormally connected when the feedback signal of the handshake chip 17 is not received. When the electrode sheet 10 is connected normally, the electric field transmitter 30 or the adapter 20 controls all the grounding switches 25 to be disconnected and the input terminals 2 of all the two-way switching switches 26 to be turned on and the sampling terminals 1 to be turned off so that all the dual-purpose signal lines 19 and the AC signal lines 28 are turned on. At this time, all the electrode units 12 of the electrode sheet 10 can apply the AC signal; 2) the sampling terminals 1 of all the two-way switching switches 26 are turned on and the input terminals 2 are turned off, and the grounding switches 25 are turned on in sequence to obtain the temperature detection signals of the temperature sensors 14 of the electrode units 12 of the row groups of the electrode sheet 10 in sequence. Among them, no operation is required for the grounding switches 25 in the idle disconnected state.

[0128] refer to Figure 7 FIG. 1 is a circuit connection diagram of a tumor electric field treatment system according to a third embodiment of the present application, showing the electrode sheet 10E of the third embodiment and Figure 1 . The electrode sheet 10E is provided with 13 electrode units 12 like the electrode sheet 10D in the second embodiment, but the specific circuit arrangement is different. The flexible circuit board 11E of the electrode sheet 10E also arranges the 13 electrode units 12 into three rows and five columns on the circuit, but two rows each have four electrode units 12, and the remaining row has five electrode units 12. The flexible circuit board 11E of the electrode sheet 10E is also embedded with three grounding wires 18, five dual-purpose signal wires 19, one grounding trace 171 connected to the ground pin of the handshake chip 17 and any grounding wire 28 at the same time, and one communication wire 172 connected to the communication pin of the handshake chip 17. Each grounding line 18 is used to ground the grounding terminal 14-1 of the temperature sensor 14 of each electrode unit 12 in a corresponding row group, and each dual-purpose signal line 19 short-circuits the dielectric element 15 of each electrode unit 12 in each column group and the signal terminal 14-2 of each temperature sensor 14, so as to receive a temperature detection signal or transmit an AC signal. The grounding line 18 connected to the grounding trace 171 also grounds the ground pin of the handshake chip 17.

[0129] The three grounding wires 18 of the electrode sheet 10E include a first grounding wire 18-1, a second grounding wire 18-2, and a third grounding wire 18-3. The first row group includes electrode units 12-1 to 12-4, the second row group includes electrode units 12-5 to 12-8, and the third row group includes electrode units 12-9 to 12-13. Specifically, the first grounding wire 18-1 is used to ground the grounding ends 14-1 of the temperature sensors 14 of the electrode units 12-1 to 12-4 in the first row group; the second grounding wire 18-2 is used to ground the grounding ends 14-1 of the temperature sensors 14 of the electrode units 12-5 to 12-8 in the second row group, and the third grounding wire 18-3 is used to ground the grounding ends 14-1 of the temperature sensors 14 of the electrode units 12-9 to 12-13 in the third row group and to ground the ground pin of the handshake chip 17 through the grounding trace 171 connected to the ground pin of the handshake chip 17. In short, each grounding line 18 short-circuits the grounding terminals 14 - 1 of the temperature sensors 14 of all the electrode units 12 in each row group and grounds them, and one of the grounding lines 18 also short-circuits the grounding pin of the handshake chip 17 to ground.

[0130] The five dual-purpose signal lines 19 of the electrode sheet 10E include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, a third dual-purpose signal line 19-3, a fourth dual-purpose signal line 19-4, and a fifth dual-purpose signal line 19-5. One end of the first dual-purpose signal line 19-1 is connected to the dielectric elements 15 of the three electrode units 12, the electrode unit 12-1, the electrode unit 12-5, and the electrode unit 12-9, and the signal end 14-2 of the temperature sensor 14; one end of the second dual-purpose signal line 19-2 is connected to the dielectric elements 15 of the three electrode units 12, the electrode unit 12-2, the electrode unit 12-6, and the electrode unit 12-10, and the signal end 14-2 of the temperature sensor 14; one end of the third dual-purpose signal line 19-3 is connected to the dielectric elements 15 of the three electrode units 12, the electrode unit 12-6, and the electrode unit 12-10, and the signal end 14-2 of the temperature sensor 14; one end of the third dual-purpose signal line 19-4 is connected to the dielectric elements 15 of the three electrode units 12, the electrode unit 12-1, and the electrode unit 12-20, and the signal end 14-2 of the temperature sensor 14 -3, electrode unit 12-7, electrode unit 12-11, and the respective dielectric elements 15 of the three electrode units 12, as well as the signal ends 14-2 of the respective temperature sensors 14; one end of the fourth dual-purpose signal line 19-4 is connected to the respective dielectric elements 15 of the three electrode units 12, as well as the signal ends 14-2 of the respective temperature sensors 14, respectively, electrode unit 12-4, electrode unit 12-8, and electrode unit 12-12; one end of the fifth dual-purpose signal line 19-5 is connected to the dielectric element 15 of the electrode unit 12-13 and the signal end 14-2 of the temperature sensor 14. In short, each dual-purpose signal line 19 short-circuits the respective dielectric elements 15 of the electrode units 12 in the corresponding column group and the signal ends 14-2 of the respective temperature sensors 14 in parallel and is used to connect to the adapter 20.

[0131] The first grounding switch 25-1, the second grounding switch 25-2 and the third grounding switch 25-3 on the adapter 20 are electrically connected to the first grounding line 18-1, the second grounding line 18-2 and the third grounding line 18-3 of the electrode sheet 10E through the first connector 40E, and the fourth grounding switch 25-4 is in an idle disconnected state. The first two-way switch 26-1, the second two-way switch 26-2, the third two-way switch 26-3, the fourth two-way switch 26-4 and the fifth two-way switch 26-5 on the adapter 20 are electrically connected to the first two-purpose signal line 19-1, the second two-purpose signal line 19-2, the third two-purpose signal line 19-3, the fourth two-purpose signal line 19-4 and the fifth two-purpose signal line 19-5 of the electrode sheet 10E through the first connector 40E. A communication transmission line 211 on the adapter 20 is electrically connected to the communication line 172 connected to the communication pin of the handshake chip 17 of the electrode sheet 10E.

[0132] The working mode of the tumor electric field treatment system formed by the electrode sheet 10E, the adapter 20 and the electric field generator 30 is the same as the aforementioned tumor electric field treatment system 100. After the electric field generator 30 controls the adapter 20 and the handshake chip 17 of the electrode sheet 10E to complete the handshake communication and confirm that the electrode sheet 10E is connected normally, when all the grounding switches 25 are disconnected and the input terminals 2 of all the two-way switching switches 26 are turned on and the sampling terminals 1 are disconnected, all the dual-purpose signal lines 19 and the AC signal lines 28 are turned on, and all the electrode units 12 can be applied with AC signals; when the sampling terminals 1 of all the two-way switching switches 26 are turned on and the input terminals 2 are disconnected, the temperature detection signals of the temperature sensors 14 of each electrode unit 12 of each row group can be obtained in turn by turning on each grounding switch 25 in sequence. Among them, no operation is required for the grounding switch 25 in the idle disconnected state.

[0133] refer to Figure 8As shown, the electrode sheet 10F of the fourth embodiment has 13 electrode units 12 like the electrode sheet 10D of the third embodiment, but the specific circuit arrangement is different. The flexible circuit board 11F of the electrode sheet 10F arranges the 13 electrode units 12 into four rows and four columns on the circuit, wherein three rows each have four electrode units 12, and the remaining row has one electrode unit 12. The electrode sheet 10F includes four grounding wires 18, four dual-purpose signal wires 19, one grounding trace 171 connected to the ground pin of the handshake chip 17 and any grounding wire 28 at the same time, and one communication wire 172 connected to the communication pin of the handshake chip 17. Each grounding wire 18 is used to ground the grounding terminal 14-1 of the temperature sensor 14 of each electrode unit 12 in the corresponding row group, and each dual-purpose signal wire 19 short-circuits the dielectric element 15 of each electrode unit 12 in each column group and the signal terminal 14-2 of each temperature sensor 14, respectively, for receiving temperature detection signals or transmitting AC signals. A ground line 18 connected to the ground trace 171 also grounds the ground pin of the handshake chip 17 .

[0134] The four grounding wires 18 of the electrode sheet 10F include a first grounding wire 18-1, a second grounding wire 18-2, a third grounding wire 18-3, and a fourth grounding wire 18-4. The first row group includes electrode units 12-1 to 12-4, the second row group includes electrode units 12-5 to 12-8, the third row group includes electrode units 12-9 to 12-12, and the fourth row group includes electrode unit 12-13. Specifically, the first grounding line 18-1 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of the electrode units 12-1 to 12-4 in the first row group; the second grounding line 18-2 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of the electrode units 12-5 to 12-8 in the second row group; the third grounding line 18-3 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of the electrode units 12-9 to 12-12 in the third row group; and the fourth grounding line 18-4 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of the electrode units 12-13 in the fourth row group. The fourth grounding line 18-4 is also connected to the grounding trace 171 connected to the ground pin of the handshake chip 17. In short, each grounding line 18 short-circuits the grounding terminals 14-1 of the temperature sensors 14 of all the electrode units 12 in each row group and grounds them, and one of the grounding lines 18 also short-circuits the ground pin of the handshake chip 17 to ground.

[0135] The four dual-purpose signal lines 19 of the electrode sheet 10F include a first dual-purpose signal line 19 - 1 , a second dual-purpose signal line 19 - 2 , a third dual-purpose signal line 19 - 3 , and a fourth dual-purpose signal line 19 - 4 . One end of the first dual-purpose signal line 19-1 is connected to the dielectric elements 15 of the four electrode units 12, namely, electrode unit 12-1, electrode unit 12-5, electrode unit 12-9 and electrode unit 12-13, and the signal end 14-2 of the temperature sensor 14; one end of the second dual-purpose signal line 19-2 is connected to the dielectric elements 15 of the three electrode units 12, namely, electrode unit 12-2, electrode unit 12-6 and electrode unit 12-10, and the signal end 14-2 of the temperature sensor 14; one end of the third dual-purpose signal line 19-3 is connected to the dielectric elements 15 of the three electrode units 12, namely, electrode unit 12-3, electrode unit 12-7 and electrode unit 12-11, and the signal end 14-2 of the temperature sensor 14; one end of the fourth dual-purpose signal line 19-4 is connected to the dielectric elements 15 of the three electrode units 12, namely, electrode unit 12-4, electrode unit 12-8 and electrode unit 12-12, and the signal end 14-2 of the temperature sensor 14. In short, each dual-purpose signal line 19 short-circuits the dielectric elements 15 of the electrode units 12 in the same column group and the signal terminals 14 - 2 of the temperature sensors 14 in parallel and is used to connect to the adapter 20 .

[0136] The first grounding switch 25-1, the second grounding switch 25-2, the third grounding switch 25-3 and the fourth grounding switch 25-4 on the adapter 20 are electrically connected to the first grounding line 18-1, the second grounding line 18-2, the third grounding line 18-3 and the fourth grounding line 18-4 of the electrode sheet 10F through the first connector 40F. The first two-way switch 26-1, the second two-way switch 26-2, the third two-way switch 26-3 and the fourth two-way switch 26-4 on the adapter 20 are electrically connected to the first two-purpose signal line 19-1, the second two-purpose signal line 19-2, the third two-purpose signal line 19-3 and the fourth two-purpose signal line 19-4 through the first connector 40F, and the fifth two-way switch 26-5 is in an idle disconnected state. A communication transmission line 211 on the adapter 20 is electrically connected to the communication line 172 connected to the communication pin of the handshake chip 17 of the electrode sheet 10F.

[0137] The working mode of the tumor electric field treatment system formed by the electrode sheet 10F, the adapter 20 and the electric field generator 30 is the same as the aforementioned tumor electric field treatment system 100. After the handshake communication is completed with the first controller 22 of the adapter 20 through the handshake chip 17 and the electrode sheet 10F is confirmed to be connected normally, when all the grounding switches 25 are disconnected and the input terminals 2 of all the two-way switching switches 26 are turned on, all the dual-purpose signal lines 19 and the AC signal lines 28 are turned on, and all the electrode units 12 are connected to the AC signal; when the sampling terminals 1 of all the two-way switching switches 26 are turned on, the temperature detection signals of the temperature sensors 14 of the electrode units 12 of each row group can be obtained in turn by turning on each grounding switch 25 in sequence. Among them, no operation can be performed on the idle grounding switches 25 and / or idle two-way switching switches 26.

[0138] refer to Fig. 9 As shown, it is a schematic diagram of the circuit connection of an electrode sheet and an adapter 20 for another embodiment of the tumor electric field treatment system of the present application. In terms of electrical connection, the difference between the electrode sheet 10H in this embodiment and the aforementioned electrode sheet is also in: the number of electrode units 12 and the arrangement of the electrode units 12 in the circuit connection. The electrode sheet 10H in this embodiment is provided with 9 electrode units 12, and the flexible circuit board 11H of the electrode sheet 10H arranges these 9 electrode units 12 into two rows and five columns in the circuit connection, one row has 5 electrode units 12, and the other row has 4 electrode units 12. The flexible circuit board 11H of the electrode sheet 10H is embedded with 2 grounding wires 18, 5 dual-purpose signal wires 19, 1 grounding trace 171 connected to the ground pin of the handshake chip 17 and any grounding wire 28 at the same time, and 1 communication wire 172 connected to the communication pin of the handshake chip 17. Each grounding line 18 is used to ground the grounding terminal 14-1 of the temperature sensor 14 of each electrode unit 12 in a corresponding row group. One of the grounding lines 18 is also used to ground the grounding pin of the handshake chip 17. Each dual-purpose signal line 19 short-circuits the dielectric element 15 of each electrode unit 12 in each column group and the signal terminal 14-2 of each temperature sensor 14, respectively, for receiving temperature detection signals or transmitting alternating current signals.

[0139] The two grounding wires 18 of the electrode sheet 10H are respectively the first grounding wire 18-1 and the second grounding wire 18-2. In the two row groups of the electrode sheet 10H, the first row group includes electrode units 12-1 to 12-5, and the second row group includes electrode units 12-6 to 12-9. Specifically, the first grounding wire 18-1 is used to ground the grounding ends 14-1 of the temperature sensors 14 of the electrode units 12-1 to 12-5 in the first row group; the second grounding wire 18-2 is used to ground the grounding ends 14-1 of the temperature sensors 14 of the electrode units 12-6 to 12-9 in the second row group and at the same time ground the ground pin of the handshake chip 17 through the grounding trace 171 connected to the ground pin of the handshake chip 17. In short, each grounding wire 18 short-circuits the grounding ends 14-1 of the temperature sensors 14 of all electrode units 12 in each row group and grounds them, and one of the grounding wires 18 also grounds the ground pin of the handshake chip 17.

[0140] The five dual-purpose signal lines 19 of the electrode sheet 10H include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, a third dual-purpose signal line 19-3, a fourth dual-purpose signal line 19-4, and a fifth dual-purpose signal line 19-5. One end of the first dual-purpose signal line 19-1 is connected to the dielectric elements 15 of the two electrode units 12, electrode unit 12-1 and electrode unit 12-6, and the signal end 14-2 of the temperature sensor 14; one end of the second dual-purpose signal line 19-2 is connected to the dielectric elements 15 of the two electrode units 12, electrode unit 12-2 and electrode unit 12-7, and the signal end 14-2 of the temperature sensor 14; one end of the third dual-purpose signal line 19-3 is connected to the dielectric elements 15 of the two electrode units 12, electrode unit 12-3 and electrode unit 12-8, and the signal end 14-2 of the temperature sensor 14; one end of the fourth dual-purpose signal line 19-4 is connected to the dielectric elements 15 of the two electrode units 12, electrode unit 12-9, and the signal end 14-2 of the temperature sensor 14; one end of the fifth dual-purpose signal line 19-5 is connected to the dielectric element 15 of the electrode unit 12-5 and the signal end 14-2 of the temperature sensor 14. In short, each dual-purpose signal line 19 short-circuits the dielectric elements 15 of each electrode unit 12 in a corresponding column group and the signal terminals 14 - 2 of each temperature sensor 14 in parallel and is used to connect to the adapter 20 .

[0141] The first grounding switch 25-1 and the second grounding switch 25-2 on the adapter 20 are electrically connected to the first grounding line 18-1 and the second grounding line 18-2 of the electrode sheet 10H through the first connector 40H, and the third grounding switch 25-3 and the fourth grounding switch 25-4 are in an idle disconnected state. The first two-way switch 26-1, the second two-way switch 26-2, the third two-way switch 26-3, the fourth two-way switch 26-4 and the fifth two-way switch 26-5 on the adapter 20 are electrically connected to the first two-purpose signal line 19-1, the second two-purpose signal line 19-2, the third two-purpose signal line 19-3, the fourth two-purpose signal line 19-4 and the fifth two-purpose signal line 19-5 through the first connector 40H. A communication transmission line 211 on the adapter 20 is electrically connected to the communication line 172 connected to the communication pin of the handshake chip 17 of the electrode sheet 10H.

[0142] The working mode of the tumor electric field treatment system formed by the electrode sheet 10H, the adapter 20 and the electric field generator 30 is the same as the aforementioned tumor electric field treatment system 100. After the electric field generator 30 controls the adapter 20 to complete the handshake communication with the handshake chip 17 of the electrode sheet 10E and confirms that the electrode sheet 10E is connected normally, when all grounding switches 25 are disconnected and the input terminals 2 of all bidirectional switching switches 26 are turned on and the sampling terminals 1 are disconnected, all dual-purpose signal lines 19 and AC signal lines 28 are turned on, and all electrode units 12 are connected to the AC signal; when the sampling terminals 1 of all bidirectional switching switches 26 are turned on and the input terminals 2 are disconnected, the temperature detection signals of the temperature sensors 14 of each electrode unit 12 of each row group can be obtained in turn by turning on each grounding switch 25 in sequence. Among them, no operation is required for the grounding switch 25 in the idle disconnected state.

[0143] In the previous embodiment, the number of grounding switches 25 corresponding to each electrode sheet 10, 10D, 10E, 10F, 10H of the adapter 20 is fixed to 4, and the number of bidirectional switching switches 26 corresponding to each electrode sheet 10, 10D, 10E, 10F, 10H is fixed to 5, which can be applied to a variety of electrode sheets 10, 10D, 10E, 10F, 10H with different numbers of electrode units 12. However, in some cases, there will be grounding switches 25 in an idle disconnected state and / or bidirectional switching switches 26 in an idle disconnected state, which will be more complicated in program control. In order to simplify the control program, a specific adapter corresponding to the number of grounding wires 18 and the number of dual-purpose signal wires 19 of the electrode sheet can be provided to avoid the occurrence of grounding switches 25 in an idle disconnected state and / or bidirectional switching switches 26 in an idle disconnected state, which is convenient for program control. That is, in other embodiments, the number of grounding switches 25 in each group of grounding switches 25 provided on the adapter 20 can be set according to the number of row groups into which the electrode units 12 of the corresponding electrode sheet are divided in circuit connection, or according to the number of grounding lines 18 on the flexible circuit board of the corresponding electrode sheet; the number of bidirectional switching switches 26 in each group of bidirectional switching switches 26 provided on the adapter 20 can be set according to the number of column groups into which the electrode units 12 of the corresponding electrode sheet are divided in circuit connection, or according to the number of dual-purpose signal lines 19 on the flexible circuit board of the corresponding electrode sheet. Preferably, the number of grounding switches 25 in each group of grounding switches 25 in the adapter 20 is equal to the number of row groups into which the electrode units 12 of the corresponding electrode sheet are divided in circuit connection, or equal to the number of grounding lines 18 on the flexible circuit board of the corresponding electrode sheet; the number of bidirectional switching switches 26 in each group of bidirectional switching switches 26 provided on the adapter 20 is equal to the number of column groups into which the electrode units 12 of the corresponding electrode sheet are divided in circuit connection, or equal to the number of dual-purpose signal lines 19 on the flexible circuit board of the corresponding electrode sheet.

[0144] The present invention also provides a method for detecting the temperature of the electrode sheet 10 used in the tumor electric field treatment system 100, referring to Fig.10 As shown, the method includes:

[0145] Step S10 : performing handshake communication with the handshake chip 17 of the electrode sheet 10 through the adapter 20 to determine the connection status of the corresponding electrode sheet 10 .

[0146] Step S20: When the electrode sheet 10 and the adapter 20 are connected normally, the switch states of each grounding switch 25 and each bidirectional switching switch 26 corresponding to the electrode sheet 10 are configured through the adapter 20, so that the temperature signals detected by each temperature sensor 14 in each row group are sampled in turn through the corresponding temperature sampling points.

[0147] The present invention also provides an electrode sheet type identification method, which is performed when all temperature sensors of the electrode sheet are normally connected. In addition to the above steps S10 and S20, the method further includes:

[0148] Step S30 : identifying the type of the corresponding electrode sheet 10 according to the sampled temperature signals detected by all the temperature sensors 14 of the corresponding electrode sheet 10 .

[0149] In step S30, the temperature signals detected by all the temperature sensors 14 of the corresponding electrode sheet 10 are sampled and obtained as temperature simulation signals. Step S30 specifically includes the following steps:

[0150] Step S301: performing digital-to-analog conversion on all sampled temperature analog signals to obtain a number of AD sampling values;

[0151] Step S302: determining the number of electrode units 12 of the corresponding electrode sheet 10 according to a number of AD sampling values;

[0152] Step S303 : determining the type of the corresponding electrode sheet 10 according to the number of electrode units 12 .

[0153] The present invention also provides a method for determining an abnormal temperature of an electrode sheet. The abnormal temperature determination of the electrode sheet is performed during the process of applying an alternating current signal to each electrode unit of the electrode sheet for tumor electric field therapy. In addition to the above steps S10 and S20, the method also includes the following steps:

[0154] Step S40: determining whether the corresponding electrode sheet 10 has a temperature abnormality based on the sampled temperature signals detected by all the temperature sensors of the corresponding electrode sheet.

[0155] Step S40 specifically includes the following steps:

[0156] Step S401: comparing all sampled temperature signals with a preset temperature threshold;

[0157] Step S402: Determine whether the electrode sheet has temperature abnormality according to the comparison result.

[0158] The comparison results in step S402 include the temperature signal being less than the preset temperature threshold and the temperature signal being greater than or equal to the preset temperature threshold. The judgment of temperature abnormality is specifically: when there is a temperature signal greater than or equal to the preset temperature threshold among all the sampled temperature signals, the electrode sheet temperature is judged to be abnormal; when all the sampled temperature signals are less than the preset temperature threshold, the electrode sheet temperature is judged to be normal. The preset temperature threshold is 39°C-44°C, preferably 41°C.

[0159] The present invention also includes an alternating electric signal regulation method, which includes, in addition to step S10 and step S20, further including: regulating the alternating electric signal applied to the corresponding electrode sheet according to the sampled temperature signals detected by all temperature sensors of the corresponding electrode sheet. The regulation is to adjust the voltage, current or power of the alternating electric signal.

[0160] refer to Fig.11 As shown, the present invention also provides an electric field control method applied to the tumor electric field treatment system 100, and the electric field control method includes the following steps:

[0161] In step 101, tumor treatment field system 100 is connected.

[0162] Specifically, the four electrode sheets 10 are connected to the adapter 20 respectively, the adapter 20 is connected to the electric field generator 30, and the electric field generator 30 is connected to an adapted power source.

[0163] In step 102, it is detected whether the user issues a command to turn on the electric field. If no command to turn on the electric field is detected, step 102 is repeated; if an electric field turn-on command is detected, step 103 is entered.

[0164] In step 103, after the electric field generator 30 of the tumor electric field therapy system 100 sends a handshake signal to the electrode sheet 10 connected to the X1 port through the second connector 50, the adapter 20, and the first connector 40 connected to the X1 port, the first controller 22 of the adapter 20 receives the feedback signal from the electrode sheet 10 of the X1 port through the corresponding communication transmission line 211 to determine whether the handshake is passed; if not, go to step 105; if passed, go to step 106.

[0165] This judgment step can occur in the adapter 20 or in the electric field generator 30. In this embodiment, the judgment step occurs in the adapter 20. Specifically, when the electrode sheet 10 at the X1 port is connected normally, its handshake chip 17 can receive the handshake request signal of the electric field generator 30, and feedback the handshake status to the first controller 22 of the adapter 20, and the first controller 22 determines that the handshake is successful. On the contrary, when the electrode sheet 10 at the X1 port is abnormally connected, the first controller 22 of the adapter 20 cannot obtain the feedback signal of its handshake chip 17, and the first controller 22 determines that the handshake fails.

[0166] In step 105 , the tumor electric field treatment system 100 issues an alarm due to handshake failure and then enters step 101 .

[0167] In step 106, after the electric field generator 30 sends a handshake signal to the electrode sheet 10 connected to the X2 port through the second connector 50, the adapter 20, and the first connector 40 connected to the X2 port, the first controller 22 on the adapter 20 receives the feedback signal from the electrode sheet 10 of the X2 port through the corresponding communication transmission line 211, and determines whether the handshake passes. If not, go to step 105; if passed, go to step 107.

[0168] This judgment step can occur in the adapter 20 or in the electric field generator 30. In this embodiment, the judgment step occurs in the adapter 20. Specifically, when the electrode sheet 10 at the X2 port is connected normally, its handshake chip 17 can receive the handshake request signal of the electric field generator 30, and feedback the handshake status to the first controller 22 of the adapter 20, and the first controller 22 determines that the handshake is successful. On the contrary, when the electrode sheet 10 at the X2 port is abnormally connected, the first controller 22 of the adapter 20 cannot obtain the feedback signal of its handshake chip 17, and the first controller 22 determines that the handshake fails.

[0169] In step 107, after the electric field generator 30 sends a handshake signal to the electrode sheet 10 connected to the Y1 port through the second connector 50, the adapter 20, and the first connector 40 connected to the Y1 port, the first controller 22 on the adapter 20 receives the feedback signal from the electrode sheet 10 of the Y1 port through the corresponding communication transmission line 211, and determines whether the handshake is passed. If not, go to step 105; if passed, go to step 108.

[0170] This judgment step can occur in the adapter 20 or in the electric field generator 30. In this embodiment, the judgment step occurs in the adapter 20. Specifically, when the electrode sheet 10 at the Y1 port is connected normally, its handshake chip 17 can receive the handshake request signal of the electric field generator 30, and feedback the handshake status to the first controller 22 of the adapter 20, and the first controller 22 determines that the handshake is successful. On the contrary, when the electrode sheet 10 at the Y1 port is abnormally connected, the first controller 22 of the adapter 20 cannot obtain the feedback signal of its handshake chip 17, and the first controller 22 determines that the handshake fails.

[0171] In step 108, after the electric field generator 30 sends a handshake signal to the electrode sheet 10 connected to the Y2 port through the second connector 50, the adapter 20, and the first connector 40 connected to the Y2 port, the first controller 22 on the adapter 20 receives the feedback signal from the electrode sheet 10 of the Y2 port through the corresponding communication transmission line 211, and determines whether the handshake is passed. If not, go to step 105; if passed, go to step 109.

[0172] This judgment step can occur in the adapter 20 or in the electric field generator 30. In this embodiment, the judgment step occurs in the adapter 20. Specifically, when the electrode sheet 10 at the Y1 port is connected normally, its handshake chip 17 can receive the handshake request signal of the electric field generator 30, and feedback the handshake status to the first controller 22 of the adapter 20, and the first controller 22 determines that the handshake is successful. On the contrary, when the electrode sheet 10 at the Y2 port is abnormally connected, the first controller 22 of the adapter 20 cannot obtain the feedback signal of its handshake chip 17, and the first controller 22 determines that the handshake fails.

[0173] In the above steps 103, 106, 107, and 108, after receiving the handshake signal from the tumor electric field treatment system 100, the adapter 20 needs to control the corresponding ground switch 25 and the bidirectional switch 26 through the first controller 22, so that only one ground switch 25 electrically connected to the handshake chip 17 is closed, and the other ground switches 24 are all disconnected, and the sampling terminals 1 of the corresponding bidirectional switch 26 are all turned on and the input terminals 2 are all disconnected, so that the handshake chip 17 is electrically connected to the ground pin GND of the adapter 20 through the first connector 40, so that the handshake chip 17 can work normally. If the electric field generator 30 and the adapter 20, the adapter 20 and the adapter 20, and the adapter 20 and the electrode sheet 10 are all connected normally, then the handshake signal sent by the electric field generator 30 can eventually reach the handshake chip 17 of the electrode sheet 10, and the handshake state of the handshake chip 17 can be fed back to the electric field generator 30. If at least one connection abnormality occurs between the electric field generator 30 and the adapter 20, between the adapter 20 and the adapter 20, and between the adapter 20 and the electrode sheet 10, the handshake chip 17 cannot connect VCC and GND to form a loop, resulting in the adapter 20 and the electric field generator 30 receiving the handshake status as an empty signal, and the handshake fails.

[0174] In step 109, electric field generator 30 of tumor electric field treatment system 100 sets electric field parameters and then proceeds to step 110. Electric field parameters include the frequency of the alternating electric signal, the amplitude of the voltage or current or power, etc.

[0175] In step 110, the adapter 20 sends a temperature reading request to the first connector 40 at the Y1 port and the first connector 40 at the Y2 port to collect temperature detection signals corresponding to a total of 40 temperature sensors 14 on the electrode sheet 10 at the Y1 port and the electrode sheet 10 at the Y2 port, and then enters step 111.

[0176] In step 111 , the tumor electric field treatment system 100 determines the types of the electrode sheet 10 at the Y1 port and the electrode sheet 10 at the Y2 port by collecting the obtained temperature signals and then proceeds to step 112 .

[0177] The types of the electrode sheet 10 at the Y1 port and the electrode sheet 10 at the Y2 port are determined by determining the number of temperature sensors 14 of the electrode sheet 10 at the Y1 port and the electrode sheet 10 at the Y2 port, respectively, according to the number of temperature detection signals of the electrode sheet 10 at the Y1 port and the temperature detection signals of the electrode sheet 10 at the Y2 port. This determination process can occur in the adapter 20 or in the electric field generator 30. In this embodiment, the electrode sheet 10 has 20 temperature sensors 14, so there are 40 valid temperature signals in total.

[0178] In step 112, tumor electric field treatment system 100 determines whether the temperature signal collected by adapter 20 is abnormal, and if so, proceeds to step 114. If the temperature signals are normal, proceeds to step 113.

[0179] In step 113 , the electric field generator 30 applies an alternating current signal to the pair of electrode sheets 10 connected to the Y1 and Y2 ports, and stops applying the alternating current signal to the pair of electrode sheets 10 connected to the X1 and X2 ports and proceeds to step 115 .

[0180] In step 114 , the tumor electric field therapy system 100 generates an alarm due to an abnormal temperature signal of the electrode sheet 10 connected to the Y1 port or the electrode sheet 10 connected to the Y2 port, and then immediately enters step 120 .

[0181] In step 115, the adapter 20 sends a temperature reading request to the first connector 40 of the X1 port and the first connector 40 of the X2 port to collect temperature signals corresponding to all temperature sensors 14 on the electrode sheet 10 at the X1 port and the electrode sheet 10 at the X2 port, and enters step 116.

[0182] In step 116 , the tumor electric field treatment system 100 determines the types of the electrode sheet 10 at the X1 port and the electrode sheet 10 at the X2 port according to the temperature signal and then proceeds to step 117 .

[0183] The types of the electrode sheet 10 at the X1 port and the electrode sheet 10 at the X2 port are determined by determining the number of temperature sensors 14 connected to the electrode sheet 10 at the X1 port and the electrode sheet 10 at the X2 port. This determination process can occur in the adapter 20 or in the electric field generator 30. In this embodiment, the electrode sheet 10 has 20 temperature sensors 14, so there are 40 valid temperature signals in total.

[0184] In step 117, tumor electric field treatment system 100 determines whether the temperature signal collected by adapter 20 is abnormal, and if so, proceeds to step 114. If all 40 valid temperature signals are normal, proceeds to step 118.

[0185] In step 118, the electric field generator 30 applies an alternating electric signal to a pair of electrode sheets 10 connected to the X1 and X2 ports, and stops applying an alternating electric signal to a pair of electrode sheets 10 connected to the Y1 and Y2 ports and proceeds to step 119. The total time of steps 113, 115, 116, 117 to 118 is fixed, and the total time is 1 second.

[0186] In step 119, the tumor electric field therapy system 100 executes subsequent steps based on whether it has received a command to turn off the electric field from the user. If it is detected that a command to turn off the electric field has been received, it proceeds to step 120; if it is not detected that a command to turn off the electric field has been received, it proceeds to step 121.

[0187] In step 120, tumor electric field treatment system 100 turns off the electric field and then proceeds to step 101. At this point, the electric field treatment ends and the next electric field turn-on command is awaited.

[0188] In step 121, the tumor electric field treatment system 100 determines whether the electric field parameters need to be adjusted according to the current electric field amplitude and the collected temperature signal. If the electric field parameters need to be adjusted, the process proceeds to step 109; if the electric field parameters do not need to be adjusted, the process proceeds to step 110 to step 119 for a loop. The total time of steps 118, step 119, step 121, step 110, step 111, step 112 to step 113 is fixed, which is 1 second in this embodiment. In this way, the tumor electric field treatment system 100 can realize the alternating electric signal in the first direction between a pair of electrodes 10 connected to the X1 and X2 ports and the alternating electric signal in the second direction between another pair of electrode sheets 10 connected to the Y1 and Y2 ports, and continuously output the alternating electric signal with a period of 2 seconds. At the same time, the tumor electric field therapy system 100 can reduce the time interval between turning off the alternating electric signal applied to a pair of electrode sheets 10 connected to the X1 and X2 ports and turning on the alternating electric signal applied to another pair of electrode sheets 10 connected to the Y1 and Y2 ports to 0s; and reduce the time interval between turning off the alternating electric signal applied to another pair of electrode sheets 10 connected to the Y1 and Y2 ports and turning on the alternating electric signal applied to a pair of electrode sheets 10 connected to the X1 and X2 ports to 0s, thereby extending the electric field therapy time while ensuring the accuracy of temperature collection.

[0189] The present application also provides some temperature detection methods and AC signal application control methods, which are described below using the electrode sheet 10 as an example.

[0190] The present application embodiment provides an electrode sheet temperature detection method, which is applied to the above-mentioned electrode sheet 10 or tumor electric field treatment system 100. Fig.12 As shown, it includes the following steps:

[0191] Step 210: When the handshake chip confirms that the electrode sheet is normally connected, control the bidirectional switches 26 electrically connected to the electrode units 12 of the electrode sheet 10 to disconnect the AC signal applied to the dielectric element 15 of the electrode unit 12 of the electrode sheet 10 and connect the DC signal applied to the signal terminal 14-2 of the temperature sensor 14 of the electrode unit 12 of the electrode sheet 10;

[0192] Step 220 : sequentially turn on the grounding switches 25 electrically connected to the grounding terminals 14 - 1 of the temperature sensors 14 of the electrode units 12 of each row group of the electrode sheet 10 to obtain temperature detection signals from the temperature sensors 14 of each electrode unit 12 of the electrode sheet 10 .

[0193] Step 210 is specifically as follows: controlling the bidirectional switch 26 electrically connected to each electrode unit 12 of the electrode sheet 10 to switch from its end electrically connected to the AC signal to its end electrically connected to the DC signal, that is, controlling the bidirectional switch 26 electrically connected to the electrode sheet 10 to switch from its input end 2 to its sampling end 1; or

[0194] The bidirectional switching switch 26 electrically connected to each electrode unit 12 of the electrode sheet 10 is controlled to switch the dielectric element 15 of each electrode unit 12 of the electrode sheet 10 from the on state to the off state, and at the same time, the signal terminal 14-2 of the temperature sensor 14 of each electrode unit 12 of the electrode sheet 10 is switched from the off state to the on state.

[0195] The electrode sheet temperature detection method of the present application can quickly and accurately obtain the temperature detection signals of all electrode units of the electrode sheet; and based on the obtained temperature detection signals of all temperature sensors of the electrode sheet, it can be judged whether the temperature sensors of the electrode sheet are faulty, whether there is an abnormality, whether the electrode sheet is qualified, and whether it needs to be replaced; it is also possible to judge whether each electrode unit of the electrode sheet is over-temperature based on the obtained temperature detection signals of all temperature sensors of the electrode sheet when each temperature sensor of the electrode sheet is normal, and then control the alternating current signal applied to the electrode sheet or to each electrode unit of the electrode sheet; it is also possible to identify the type of electrode sheet when there is no abnormality in the temperature detection signals of each temperature sensor of the electrode sheet.

[0196] Ginseng Fig.13 As shown, the embodiment of the present application also provides a method for controlling application of an alternating current signal for electric field therapy of tumors, which includes the above steps 210 and 220, and after step 220, further includes:

[0197] Step 260 : When it is determined that the electrode sheet 10 does not need to be replaced, the alternating current signal applied to each electrode unit 12 of the electrode sheet 10 is controlled or adjusted according to the temperature detection signal of the temperature sensor 14 of each electrode unit 12 of the electrode sheet 10 .

[0198] Controlling or adjusting the alternating current signal applied to each electrode unit 12 of the electrode sheet 10 in step 260 also includes:

[0199] Step 261: When the temperature detection signals of the electrode units 12 of the electrode sheet 10 obtained do not exceed the preset temperature threshold, continue to apply an alternating current signal to the electrode units 12 of the electrode sheet 10; or

[0200] Step 262 : when there is a temperature detection signal exceeding a preset temperature threshold among the temperature detection signals of all the electrode units 12 of the electrode sheet 10 , stop applying the alternating current signal to the electrode units 12 of the electrode sheet 10 .

[0201] Stopping the application of the AC signal to the electrode unit 12 of the electrode sheet 10 described in step 262 includes stopping applying the AC signal to all electrode units 12 of the electrode sheet 10, stopping applying the AC signal to the electrode unit 12 in the electrode sheet 10 whose temperature detection signal exceeds the preset temperature threshold, and stopping applying the AC signal to all electrode units 12 in the column where the electrode unit 12 in the electrode sheet 10 whose temperature detection signal exceeds the preset temperature threshold is located.

[0202] When the application of the AC signal to the electrode unit 12 in the electrode sheet 10 whose temperature detection signal exceeds the preset temperature threshold is stopped, the AC signal continues to be applied to the electrode unit 12 in the electrode sheet 10 whose temperature detection signal does not exceed the preset temperature threshold.

[0203] When the application of the AC signal to all the electrode units 12 in the column where the electrode unit 12 whose temperature detection signal exceeds the preset temperature threshold in the electrode sheet 10 is located is stopped, the AC signal continues to be applied to all the electrode units 12 in the electrode sheet 10 where the temperature detection signal does not exceed the preset temperature threshold and which are in different columns from the electrode unit 12 whose temperature detection signal exceeds the preset temperature threshold.

[0204] The process of continuing to apply the alternating current signal to the electrode sheet 10 in step 261 is specifically as follows:

[0205] Step 263: When the temperature detection signal is much lower than the preset temperature threshold, the AC signal is continuously applied to each electrode unit 12 of the electrode sheet 10 in a manner of increasing the voltage or current amplitude of the AC signal applied to each electrode unit 12 of the electrode sheet 10 or the AC signal is continuously applied to each electrode unit 12 of the electrode sheet 10 in a manner of keeping the voltage or current amplitude of the AC signal applied to each electrode unit 12 of the electrode sheet 10 unchanged; or

[0206] Step 264: When the temperature detection signal approaches a preset temperature threshold, continue to apply the AC signal to each electrode unit 12 of the electrode sheet 10 in a manner that keeps the voltage or current amplitude of the AC signal applied to each electrode unit 12 of the electrode sheet 10 unchanged, or continue to apply the AC signal to each electrode unit 12 of the electrode sheet 10 in a manner that reduces the voltage or current amplitude of the AC signal applied to each electrode unit 12 of the electrode sheet 10.

[0207] Ginseng Fig.14 As shown, the present application also provides a signal control method for tumor electric field therapy, which is used for the above-mentioned electrode sheet 10, and the method includes:

[0208] Step 310: Combining and controlling a group of grounding switches 25 and a group of bidirectional switching switches 26 electrically connected to the corresponding electrode sheets 10 to apply an AC signal to each electrode unit 12 of the electrode sheet 10 and executing step 320;

[0209] Step 320: Combining and controlling a group of grounding switches 25 and a group of bidirectional switching switches 26 electrically connected to the electrode sheet 10 to collect temperature detection signals of each electrode unit of the electrode sheet 10 in a row and executing step 330;

[0210] Step 330: determining a combined control mode of a group of grounding switches 25 and a group of bidirectional switching switches 26 electrically connected to the electrode sheet 10 according to the collected temperature detection signal and executing step 340;

[0211] Step 340 : Control the working state of each electrode unit 12 of the electrode sheet 10 according to the determined combined control mode of the grounding switch 25 and the bidirectional switch 26 .

[0212] The working state of each electrode unit 12 of the electrode sheet 10 described in step 340 includes: stopping applying the AC signal and continuing to collect the temperature detection signal and stopping collecting the temperature detection signal and continuing to apply the AC signal. Continuing to apply the AC signal includes continuing to apply the AC signal in a manner of increasing the voltage or current amplitude of the currently applied AC signal, continuing to apply the AC signal in a manner of keeping the voltage or current amplitude of the currently applied AC signal unchanged, and continuing to apply the AC signal in a manner of reducing the voltage or current amplitude of the currently applied AC signal.

[0213] The working state of each electrode unit 12 of the electrode sheet 10 is determined by the temperature detection signal collected by the electrode unit 12. Each electrode unit 12 of the electrode sheet 10 is divided into different areas, and each electrode unit 12 in each area can be cyclically switched between applying an AC signal and collecting a temperature detection signal through the combination control of a grounding switch 25 and a bidirectional switch 26.

[0214] The present application embodiment provides another electrode temperature detection method for a tumor electric field therapy system. Please refer to Fig.15 As shown, taking the electrode sheet 10 as an example, the temperature detection method includes:

[0215] Step 510: disconnect the input of the alternating current signal of the electrode sheet 10, perform combination control on the multiple grounding switches 25 and the multiple bidirectional switching switches 26, and obtain the temperature detection signal of the temperature sensor 14 of the electrode sheet 10 corresponding to each combination in all the combinations;

[0216] Step 520: sampling and converting the temperature detection signal detected by each temperature sensor 14 in the electrode sheet 10 to obtain a digital temperature signal;

[0217] Step 530: Transmit the digital temperature signal to the electric field generator 30 of the tumor electric field therapy system 100, so that the electric field generator 30 determines the temperature at the corresponding electrode unit 12 according to the digital temperature signal.

[0218] In step 510, “combining and controlling the plurality of grounding switches 25 and the plurality of bidirectional switching switches 26” specifically includes:

[0219] Step 511: placing all the bidirectional switches 26 at the sampling terminal 1 to conduct the electrical connection between the signal terminal 14 - 2 of each temperature sensor 14 of all electrode units 12 and the corresponding analog-to-digital converter 23;

[0220] Step 512: Sequentially and individually close one of the plurality of grounding switches 25 in a time-sharing manner to collect the temperature detection signals detected by the temperature sensors 14 of the electrode units 12 in the corresponding row group row by row.

[0221] In step 512, sequentially and individually closing one of the plurality of grounding switches 25 in a time-sharing manner can turn on the detection channel of the analog-to-digital converter 23 electrically connected to each temperature sensor 14 in the row group corresponding to the closed grounding switch 25 .

[0222] Thus, the temperature detection signals of the corresponding temperature sensors 14 in each row group can be obtained in turn, and then after being processed by the adapter 20 or the electric field generator 30, the corresponding temperatures of all the electrode units 12 on the electrode sheet 10 can be obtained; thereby making the temperature detection of the patient's body surface more comprehensive and accurate.

[0223] For the tumor electric field therapy system 100 of the embodiment of the present application, the temperature of a single electrode unit 12 can also be detected as needed. The specific process of the method for temperature detection of a certain electrode unit 12 of the electrode sheet 10 is as follows: disconnect the input of the AC signal, place the bidirectional switch 26 corresponding to the column group where the electrode unit 12 that needs to be individually measured is located at the sampling end 1, and place the remaining bidirectional switches 26 at the input end 2; at the same time, turn on and ground the grounding switch 25 corresponding to the row group where the electrode unit 12 that needs to be individually measured is located, and disconnect all the remaining grounding switches 25. In this way, the temperature detection signal of the temperature sensor 14 in the electrode unit 12 that needs to be individually measured can be sampled to obtain the temperature of the electrode unit 12. For example, the electrode unit 12 that needs to be individually measured is the electrode unit 12-1. At this time, the first two-way switch 26-1 corresponding to the electrode unit 12-1 is placed at the sampling end 1, and the remaining two-way switches (the second two-way switch 26-2, the second two-way switch 26-3, the third two-way switch 26-3 and the fourth two-way switch 26-4) are all placed at the input end 2; at the same time, the first grounding switch 25-1 corresponding to the electrode unit 12-1 is closed and grounded, and the remaining grounding switches (the second grounding switch 25-2, the third grounding switch 25-3 and the fourth grounding switch 25-4) are all disconnected. In this way, the temperature of the electrode unit 12-1 can be detected.

[0224] The present application also provides another method for applying an alternating current signal for tumor electric field therapy, which is applied to the above tumor electric field therapy system. Figure 1 The tumor electric field treatment system 100 in FIG. Fig.16 As shown, the AC signal application method includes:

[0225] Step 610: determining the area of ​​the electrode unit 12 in the electrode sheet 10 where the alternating current signal needs to be applied;

[0226] Step 611: Combining and controlling a plurality of grounding switches 25 and a plurality of bidirectional switching switches 26 electrically connected to the electrode sheet 10 to apply an alternating current signal.

[0227] In step 611, “combining and controlling a plurality of grounding switches 25 and a plurality of bidirectional switching switches 26 electrically connected to the electrode sheet 10” is specifically as follows:

[0228] Step 612: disconnect all grounding switches 25 electrically connected to the electrode sheet 10;

[0229] Step 613: determining the column group where the electrode units 12 to which the AC signal needs to be applied are located according to the area where the electrode units 12 to which the AC signal needs to be applied are located;

[0230] Step 614: determining the bidirectional switch 26 electrically connected to the electrode units 12 in the column group according to the column group where the electrode units 12 to which the AC signal needs to be applied are located;

[0231] In step 610, every four adjacent electrode units 12 in the electrode sheet 10 are divided into a region, and the four electrode units 12 in each region correspond to a column group, which are connected to a dual-purpose signal line 19 corresponding to the same bidirectional switch 26. In other embodiments, the electrode units 12 are divided in other ways, which will not be repeated here.

[0232] Step 615: Control the bidirectional switching switch 26 electrically connected to the electrode unit 12 to which an AC signal needs to be applied so that the electrode unit 12 to which an AC signal needs to be applied is electrically connected to the AC signal line 28 to apply the AC signal; at the same time, control the remaining bidirectional switching switches 26 so that the electrical connection between each electrode unit 12 in the area where no AC signal needs to be applied and the AC signal line 28 is disconnected to stop applying the AC signal.

[0233] In step 615, "the electrode units to which an AC signal needs to be applied are electrically connected to the AC signal line 28 to apply the AC signal and the electrode units 12 in the area where the AC signal does not need to be applied are electrically disconnected from the AC signal line 28 to stop applying the AC signal" is achieved by placing the bidirectional switching switch 26 electrically connected to the electrode units 12 in the column group corresponding to the area to which the AC signal is to be applied in the electrode sheet 10 at its input terminal 2, and placing all the bidirectional switching switches 26 electrically connected to the electrode units 12 in the remaining column groups at the sampling terminal 1.

[0234] When the above methods are applied to the electrode sheets 10D, 10E, 10F and 10H in other embodiments, since there are grounding switches 25 in an idle disconnected state and / or bidirectional switching switches 26 in an idle disconnected state on the adapter 20 that are not electrically connected to the corresponding electrode sheets 10D, 10E, 10F and 10H, the corresponding grounding switches 25 in an idle disconnected state and / or bidirectional switching switches 26 in an idle disconnected state do not need to be controlled accordingly.

[0235] Although various operations are depicted in the drawings as being in a particular order, this should not be understood as requiring that the operations must be performed in the particular order shown or in sequential order, nor should it be understood as requiring that all illustrated operations must be performed to achieve desirable results.

[0236] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present application, rather than to limit them; although the present application has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein by equivalents; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the present application, and they should all be included in the scope of the claims and specification of the present application. In particular, as long as there is no structural conflict, the various technical features mentioned in the various embodiments can be combined in any way. The present application is not limited to the specific embodiments disclosed herein, but includes all technical solutions that fall within the scope of the claims.

Claims

1. An electrode sheet for a tumor electric field treatment system, characterized in that: include: A plurality of electrode units, wherein the plurality of electrode units are divided into a plurality of row groups and a plurality of column groups in circuit connection, and are arranged in at least two row groups or three column groups in circuit connection; as well as A handshake chip, wherein the handshake chip is configured to determine the connection status of the electrode sheet through handshake communication; as well as The flexible circuit board is configured to be arranged on the handshake chip and the plurality of electrode units at intervals, and has multiple conductive traces embedded therein, the multiple conductive traces comprising: A plurality of grounding wires, corresponding to the plurality of row groups respectively, each of the grounding wires being configured to short-circuit a corresponding portion of each electrode unit in the corresponding row group to ground; and multiple dual-purpose signal lines, corresponding to the plurality of column groups respectively, each of the dual-purpose signal lines being configured to: transmit an alternating current signal to each electrode unit in the corresponding column group in a first mode, and transmit a direct current signal or a temperature signal detected by each electrode unit in the corresponding column group in a second mode; and a ground trace configured to ground the handshake chip; and A communication line is electrically connected to a corresponding portion of the handshake chip.

2. The electrode sheet according to claim 1, characterized in that: The number of the dual-purpose signal lines is related to the number of the column groups into which the electrode unit is divided, and the number of the ground lines is related to the number of the row groups into which the electrode unit is divided.

3. The electrode sheet according to claim 2, characterized in that: The number of the dual-purpose signal lines is equal to the number of column groups into which the electrode units are divided.

4. The electrode sheet according to claim 2, characterized in that: The number of the grounding lines is equal to the number of the row groups into which the electrode units are divided.

5. The electrode sheet according to any one of claims 1 to 4, characterized in that: Each of the electrode units includes a dielectric element for transmitting an alternating current signal and a temperature sensor having a signal terminal and a ground terminal, and the temperature sensor is used to detect the temperature of the corresponding electrode unit.

6. The electrode sheet according to claim 5, characterized in that: The dielectric element of each electrode unit is short-circuited with the signal end of the temperature sensor.

7. The electrode sheet according to claim 6, characterized in that: Each of the electrode units further includes a diode connected in series with the temperature sensor, and the temperature sensor is grounded through the diode connected in series with the temperature sensor.

8. The electrode sheet according to claim 6, characterized in that: The dielectric elements of the plurality of electrode units in the same column group are connected in parallel to the same dual-purpose signal line of the flexible circuit board, the dielectric elements of the plurality of electrode units in different column groups are connected in parallel through different dual-purpose signal lines of the flexible circuit board, the dielectric elements of the plurality of electrode units in the same row group are connected in parallel through different dual-purpose signal lines of the flexible circuit board, and the dielectric elements of the plurality of electrode units in different row groups and different column groups are connected in parallel to different dual-purpose signal lines of the flexible circuit board.

9. The electrode sheet according to claim 6, characterized in that: The dielectric elements of the plurality of electrode units in the same column group and the signal ends of the respective temperature sensors are connected in parallel through the same dual-purpose signal line of the flexible circuit board, and the dielectric elements of the plurality of electrode units in different column groups and the signal ends of the respective temperature sensors are connected in parallel through different dual-purpose signal lines of the flexible circuit board.

10. The electrode sheet according to claim 6, characterized in that: The grounding ends of the temperature sensors of the multiple electrode units located in the same row group are short-circuited through the same grounding line of the flexible circuit board, and the grounding ends of the temperature sensors of the multiple electrode units located in the same column group are connected in parallel through different grounding lines of the flexible circuit board; the signal ends of the temperature sensors of the multiple electrode units located in the same row group are connected in parallel through different dual-purpose signal lines of the flexible circuit board, and the signal ends of the temperature sensors of the multiple electrode units located in the same column group are short-circuited through the same dual-purpose signal line of the flexible circuit board.

11. The electrode sheet according to claim 6, characterized in that: The dielectric elements of the plurality of electrode units in the same row group are respectively connected in parallel through different dual-purpose signal lines of the flexible circuit board, and the dielectric elements of the plurality of electrode units in the same column group are short-circuited through the same dual-purpose signal line of the flexible circuit board.

12. The electrode sheet according to claim 6, characterized in that: The temperature signals detected by the temperature sensors in each of the row groups are sampled simultaneously after the handshake chip completes the handshake communication.

13. The electrode sheet according to claim 5, characterized in that: The sampled temperature signal detected by the temperature sensor is used to characterize the type of the electrode sheet.

14. The electrode sheet according to claim 1, characterized in that: The handshake chip has a ground pin electrically connected to the ground trace and a communication pin electrically connected to the communication line, and the ground pin is connected to one ground line among the multiple ground lines through the ground trace.

15. The electrode sheet according to claim 1, characterized in that: The handshake chip stores energy when the communication line transmits a high level and releases energy when the communication line transmits a low level.

16. The electrode sheet according to claim 5, characterized in that: The sampled temperature signal detected by the temperature sensor is also used to indicate whether the electrode sheet has a temperature abnormality.

17. A tumor electric field treatment system, characterized in that: Comprising at least one pair of electrode sheets according to any one of claims 1-16.

18. The tumor electric field treatment system according to claim 17, characterized in that: Also includes: an electric field generator configured to apply an alternating current signal to a plurality of electrode units of the electrode sheet via a dual-purpose signal line of the electrode sheet; and The adapter is connected between the electrode sheet and the electric field generator, and is configured to transmit the alternating current signal generated by the electric field generator to the multiplexed signal line of the electrode sheet, and is also configured to receive the temperature signal detected by the multiplexed signal line output of the electrode sheet, and is also configured to perform handshake communication with the handshake chip, and after completing the handshake communication, time-sharingly sample the temperature signal detected by each electrode unit in each row group.

19. The tumor electric field treatment system according to claim 18, characterized in that: The adapter comprises: An AC signal line is configured to apply an alternating current signal to each of the electrode units in the corresponding column group through the plurality of dual-purpose signal lines.

20. The tumor electric field treatment system according to claim 19, characterized in that: The adapter further comprises the switch unit, and the switch unit comprises: A plurality of groups of grounding switches, each group of grounding switches is electrically connected to a corresponding electrode sheet and comprises a plurality of grounding switches, the plurality of grounding switches in each group of grounding switches are respectively electrically connected to the plurality of grounding wires of the corresponding electrode sheet one by one and are configured to control the conduction or disconnection of the plurality of grounding wires.

21. The tumor electric field treatment system according to claim 20, characterized in that: The adapter also includes: A plurality of groups of analog-to-digital converters are electrically connected to the multiple dual-purpose signal lines of the corresponding electrode sheets, respectively, and are configured to receive the temperature signals detected by the multiple dual-purpose signal lines of the corresponding electrode sheets and convert the temperature signals from analog signals to digital signals. Wherein, each group of the analog-to-digital converters includes a plurality of detection channels, and each detection channel is used to connect a corresponding dual-purpose signal line among the plurality of dual-purpose signal lines.

22. The tumor electric field treatment system according to claim 21, characterized in that: The switch unit further comprises: A plurality of groups of bidirectional switches, corresponding to the plurality of electrode sheets respectively, each group of the bidirectional switches comprises a plurality of bidirectional switches, and the plurality of bidirectional switches in each group of the bidirectional switches are respectively electrically connected to the plurality of dual-purpose signal lines of the corresponding electrode sheets; Each of the bidirectional switches further comprises a sampling terminal electrically connected to a corresponding detection channel in the corresponding analog-to-digital converter and an input terminal electrically connected to the AC signal line.

23. The tumor electric field treatment system according to claim 22, characterized in that: The adapter also includes: The first controller is connected to the plurality of groups of grounding switches and the plurality of groups of bidirectional switching switches respectively, and is configured to: It is used to control the opening and closing states of the corresponding groups of grounding switches in turn and in a cycle, so as to conduct each of the multiple grounding wires of the corresponding electrode sheet in turn and separately; and used to control the switching state of the corresponding group of the two-way switches, so that each of the two-way switches is placed at a sampling end to output a detected temperature signal or is placed at an input end to transmit an alternating current signal; and It is used to configure the switch state of the grounding switches in the corresponding group and the switching state of the bidirectional switching switches in the corresponding group when receiving the handshake signal sent by the electric field generator so that the handshake chip can be powered on and work, and send the handshake signal to the handshake chip and judge whether the handshake communication with the handshake chip is completed according to the feedback signal of the handshake chip, and after the handshake communication is completed, by configuring the switch state of each grounding switch of the grounding switches in the corresponding group and the switching state of each bidirectional switching switch of the bidirectional switching switches in the corresponding group, so that the analog-to-digital converter of the corresponding group simultaneously samples the temperature signals detected by each temperature sensor in the corresponding row group to obtain the temperature signals, and then obtain multiple digital signals after analog-to-digital conversion.

24. The tumor electric field treatment system according to claim 23, characterized in that: The adapter also includes: The first communication unit is configured to obtain the digital signals output by the multiple groups of analog-to-digital converters and send the digital signals to the electric field generator.

25. The tumor electric field treatment system according to claim 24, characterized in that: The electric field generator is further configured to control or adjust an alternating current signal applied to a corresponding electrode unit among a plurality of electrode units of the corresponding electrode sheet according to the received digital signal.

26. The tumor electric field treatment system according to claim 24, characterized in that: The first communication unit is controlled by the first controller and serially transmits the digital signal converted by the analog-to-digital converter.

27. The tumor electric field treatment system according to claim 23, characterized in that: The first controller is further configured to identify the type of the corresponding electrode sheet according to the plurality of digital signals.

28. The tumor electric field treatment system according to claim 23, characterized in that: The first controller is also used to determine whether the corresponding electrode sheet has temperature abnormality according to a number of digital signals during the process in which the electric field generator transmits the alternating electric signal to the corresponding electrode sheet.

29. The tumor electric field treatment system according to claim 23, characterized in that: The first controller is further configured to send the plurality of digital signals to the electric field generator so that the electric field generator can identify the type of the corresponding electrode sheet according to the plurality of digital signals.

30. The tumor electric field treatment system according to claim 23, characterized in that: The electric field generator is also used to determine whether the corresponding electrode sheet has temperature abnormality according to the plurality of digital signals during the process of transmitting the alternating electric signal to the corresponding electrode sheet.

31. A temperature detection method, characterized in that: Applied to the electrode sheet as described in any one of claims 1-16 or to the tumor electric field treatment system as described in any one of claims 17-30, the method comprises the following steps: performing handshake communication with the handshake chip through the adapter to determine the connection status of the corresponding electrode sheet; when each of the electrode sheets is normally connected to the adapter, sampling the temperature signals detected by each electrode unit in each of the row groups row by row in a time-sharing manner by configuring the on and off states of the multi-channel ground lines and the multi-channel dual-purpose signal lines of the electrode sheets.

32. The temperature detection method according to claim 31, characterized in that: The multiple dual-purpose signal lines of the electrode sheet are all led to their respective sampling ends, each of the multiple grounding lines of the electrode sheet is turned on in sequence, and the temperature signals detected by each electrode unit of the electrode sheet are collected row by row through the multiple dual-purpose signal lines.

33. A signal control method for tumor electric field therapy, characterized in that: Applied to the electrode sheet as described in any one of claims 1-16 or to the tumor electric field therapy system as described in any one of claims 17-30, when the electrode sheet is confirmed to be normally connected through a handshake chip, the tumor electric field therapy signal is achieved by combining and controlling the conduction and disconnection of multiple dual-purpose signal lines and multiple ground lines, and by using multiple dual-purpose signal lines to realize cyclic switching between applying an alternating current signal and applying a direct current signal to each electrode unit of the electrode sheet for collecting or transmitting a detected temperature signal.

34. The signal control method according to claim 33, characterized in that: The process of applying an alternating current signal to each electrode unit of the electrode sheet includes the following steps: disconnecting the multiple ground lines that are electrically connected one-to-one to the electrode units in each row group of the electrode sheet, and at the same time connecting the multiple dual-purpose signal lines that are electrically connected one-to-one to the electrode units in each column group of the electrode sheet to their respective input ends to transmit the alternating current signal to each electrode unit through the multiple dual-purpose signal lines that are electrically connected to the electrode sheet.

35. The signal control method according to claim 33, characterized in that: The process of transmitting the detected temperature signal to each electrode unit of the electrode sheet includes the following steps: conducting the multiple dual-purpose signal lines electrically connected one by one to the electrode units of each column group of the electrode sheet to their respective collection ends to transmit a direct current signal to each electrode unit through the multiple dual-purpose signal lines electrically connected to the electrode sheet; and sequentially conducting one ground line among the multiple ground lines electrically connected one by one to the electrode units of each row group of the electrode sheet to complete the transmission of the detected temperature signals of all the electrode units in each row group of the electrode sheet row by row through the multiple dual-purpose signal lines electrically connected to the electrode sheet.

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