Electrode plate, tumor electric field treatment system and temperature detection and signal control method

Abstract

The invention provides an electrode plate, a tumor electric field treatment system and a temperature detection and signal control method, the electrode plate comprises a flexible circuit board and a plurality of electrode units arranged on the flexible circuit board at intervals, and the plurality of electrode units are divided into a plurality of row groups and a plurality of column groups on a circuit. The electrode unit includes a dielectric element and a temperature sensor having a signal terminal and a ground terminal, and the dielectric element is short-circuited with the signal terminal of the temperature sensor. A plurality of conductive traces are embedded in the flexible circuit board, the plurality of conductive traces comprise a plurality of grounding wires and a plurality of dual-purpose signal wires, the grounding wires are arranged in one-to-one correspondence with the column groups, and the grounding wires are in short circuit with the grounding ends of the temperature sensors corresponding to the electrode units of the corresponding column groups and then are grounded. The dual-purpose signal lines are arranged in one-to-one correspondence with the row groups, and the dual-purpose signal lines are connected in series with the electrode units of the corresponding row groups.

Description

Technical Field

[0001] The present application relates to Tumor Treating Fields (TTF) technology, and in particular to an electrode sheet, a tumor treating field system, and a temperature detection and signal control method. Background Art

[0002] Tumor electric field therapy is a method that uses low-intensity, medium- and high-frequency alternating electric fields to prevent the formation of spindle microtubules during mitosis in certain tumor cells, inhibit the separation of intracellular organelles during cell division, and induce apoptosis of cells during mitosis, thereby achieving the effect of treating tumors.

[0003] Compared with traditional cancer treatments, TTF has an innovative mechanism of action. Some physiological characteristics of tumor cells, such as geometric shape and high-frequency mitosis, make them susceptible to TTF. TTF disrupts the normal aggregation of tubulin by exerting directional forces on polar particles (such as macromolecules and organelles) within the cell. These processes may lead to physical damage to the cell membrane and cell apoptosis. At the end of cell mitosis, the structural morphology of the cleavage furrow will lead to an uneven distribution of the electric field around it. At the same time, under the influence of TTF, the electric field intensity at the cleavage furrow is significantly enhanced, and the charged substances in the cell move toward the cleavage furrow, which interferes with or even destroys the formation of the cell structure, and ultimately leads to cell division failure and apoptosis.

[0004] In the existing tumor electric field therapy system, an electric field application device is used to transmit the alternating current signal for tumor electric field therapy to the electrode sheet, and then the alternating electric field is applied to the patient's tumor site through the electrode sheet for tumor electric field therapy. When the tumor treatment electric field is applied to the patient's body, heat will accumulate at the application site, and the temperature will increase accordingly. Therefore, it is necessary to monitor the temperature at the application site. When the temperature is too high, the electric field strength needs to be adjusted in time to reduce the risk of skin burns caused by excessive temperature.

[0005] The tumor electric field therapy system includes at least one pair of electrode sheets, each of which has multiple electrode units. Even if the same alternating current signal is applied to each electrode unit, the heat generated by each electrode unit will be different due to its different position, that is, the temperature of each electrode unit on the entire electrode sheet will not be completely consistent. In this way, it is possible that the temperature of some electrode units in the entire electrode sheet exceeds the preset temperature, while the temperature of other electrode units is normal. In order to improve the effect of tumor electric field therapy, it is necessary to implement individual control on the over-temperature electrode units. However, for existing electrode sheets, implementing individual control on the electrode units requires setting a conductive trace for each electrode unit in the substrate of the electrode sheet, which will increase the number of conductive traces in the electrode sheet substrate so that the electrode sheet is not easy to bend, and the cable electrically connected to the electrode sheet will also be thickened, which increases the overall weight of the electrode sheet, which is not conducive to the application of the electrode sheet.

[0006] Therefore, it is necessary to provide an electrode sheet, a tumor electric field therapy system, a temperature detection method, and a signal application method that use fewer conductive traces to perform partition control on multiple electrode units. Summary of the invention

[0007] The first object of the present application is to provide an electrode sheet and a tumor electric field treatment system to solve or eliminate the problems in the related art.

[0008] The second object of the present application is to provide a method for detecting the temperature of an electrode sheet.

[0009] The third object of the present application is to provide a signal control method for tumor electric field therapy.

[0010] To achieve the above-mentioned purpose, the present application provides the following technical solutions: an electrode sheet for electric field therapy of tumors, comprising: a plurality of electrode units, the plurality of electrode units are divided into a plurality of row groups and a plurality of column groups on the circuit, the electrode units include a dielectric element and a temperature sensor having a signal end and a ground end, and the dielectric element is short-circuited with the signal end of the temperature sensor; and a flexible circuit board, the plurality of electrode units are arranged at intervals on the flexible circuit board, the flexible circuit board is embedded with multiple conductive traces, the multiple conductive traces include multiple grounding wires and multiple dual-purpose signal wires, the grounding wires are arranged in a one-to-one correspondence with each column group, the grounding wires are short-circuited with the grounding ends of the temperature sensors corresponding to each electrode unit of the corresponding column group and then grounded, the dual-purpose signal wires are arranged in a one-to-one correspondence with each row group, and the dual-purpose signal wires are connected in series with each electrode unit of the corresponding row group.

[0011] According to the tumor electric field therapy system of the present application, the flexible circuit board of the electrode sheet is provided with a plurality of dual-purpose signal lines, which transmit both AC signals and DC signals or collect temperature detection signals of each electrode unit. There is no need to provide a separate conductive trace used only for transmitting AC signals, thereby reducing the number of wire cores of the wires connecting the electrode sheet and the adapter.

[0012] Furthermore, each of the electrode units also includes a diode connected in series with the temperature sensor, and the temperature sensor is grounded through the diode connected in series with the temperature sensor.

[0013] Furthermore, the dual-purpose signal line selectively connects to an AC signal or a temperature measurement DC signal. When measuring temperature, multiple dual-purpose signal lines are individually connected to the DC signal in sequence, and multiple ground lines are turned on one by one in sequence; when applying an AC signal, multiple dual-purpose signal lines are fully or partially connected to the AC signal, and multiple ground lines are all disconnected.

[0014] Furthermore, the plurality of electrode units are divided into four rows and five columns, three rows and five columns, four rows and four columns, three rows and four columns, or three rows and three columns in terms of circuitry.

[0015] Furthermore, the number of electrode units in each row is less than or equal to the number of column groups.

[0016] Furthermore, the plurality of electrode units are structurally arranged into multiple rows and columns, the flexible circuit board is provided with a connection portion connecting two adjacent electrode units, and the electrode sheet is provided with a gap formed between two adjacent electrode units along the column direction and along the row direction.

[0017] In order to achieve the above-mentioned purpose, the present application also provides the following technical solution: a tumor electric field treatment system, comprising at least one pair of the aforementioned electrode sheets.

[0018] Furthermore, it also includes an electric field generator and an adapter electrically connected between the electrode sheet and the electric field generator, the adapter includes multiple groups of bidirectional switching switches and multiple groups of grounding switches, each group of bidirectional switching switches is arranged in a one-to-one correspondence with each of the electrode sheets, and the multiple dual-purpose signal lines of the electrode sheet are electrically connected one-to-one with the corresponding bidirectional switching switches of the corresponding row group, and the number of each group of bidirectional switching switches is equal to the number of the dual-purpose signal lines of the corresponding electrode sheet; each group of grounding switches is arranged in a one-to-one correspondence with each of the electrode sheets, and the multiple grounding lines of the electrode sheet are electrically connected one-to-one with the corresponding grounding switches of the corresponding column group, and the number of each group of grounding switches is equal to the number of the grounding lines of the corresponding electrode sheet.

[0019] Furthermore, the adapter includes an AC signal line, and the AC signal line is configured to provide alternating current signals to each of the electrode units in the corresponding row group through the multiple dual-purpose signal lines.

[0020] Furthermore, the adapter also includes multiple groups of analog-to-digital converters, each group of analog-to-digital converters is arranged corresponding to each of the electrode sheets and includes multiple detection channels, and each of the two-way switching switches has a first end electrically connected to the corresponding detection channel and a second end electrically connected to the AC signal line; when measuring temperature, multiple two-way switching switches are placed individually at the first end in sequence, and the remaining two-way switching switches are placed at the second end, and the multiple grounding switches electrically connected to the electrode sheets are turned on one by one in sequence; when an alternating current signal is applied, all or part of the multiple two-way switching switches electrically connected to the electrode sheets are placed at the second end, and the multiple grounding switches electrically connected to the electrode sheets are all disconnected.

[0021] Furthermore, the adapter further comprises a first controller, and the first controller and a plurality of groups of grounding switches are configured to: sequentially and cyclically control the opening and closing states of each group of grounding switches, thereby sequentially and sequentially conducting each grounding line corresponding to the electrode sheet;

[0022] Furthermore, the first controller is connected to a plurality of groups of bidirectional switches respectively, and is configured to control the switching state of the plurality of bidirectional switches in each group so that the bidirectional switches are placed at the first end or the second end.

[0023] To achieve the above-mentioned purpose, the present application also provides the following technical solutions: a temperature detection method for a tumor electric field therapy system, applied to the aforementioned tumor electric field therapy system, the method comprising the following steps: sequentially and separately connecting the multiplexed signal lines corresponding to the multiple row groups of the corresponding electrode sheets to the DC signal; and sequentially and time-sharingly turning on each of the multiple grounding lines corresponding to the multiple column groups of the corresponding electrode sheets to determine the temperature detection signal of each electrode unit in each column group of the electrode sheet by column through the multiplexed signal lines.

[0024] To achieve the above-mentioned purpose, the present application also provides the following technical solutions: a signal control method for tumor electric field therapy, applied to the aforementioned tumor electric field therapy system, wherein the tumor electric field therapy signal is controlled by combining the conduction and disconnection of multiple dual-purpose signal lines and multiple grounding lines, and the multiple dual-purpose signal lines are used to realize the cyclic switching of each electrode unit of the electrode sheet between applying an alternating current signal or transmitting a temperature detection signal; the process of applying an alternating current signal to each electrode unit of the electrode sheet includes the following steps: disconnecting the multiple grounding lines electrically connected to the electrode units of each column group of the electrode sheet in a one-to-one correspondence, and at the same time disconnecting the multiple grounding lines electrically connected to the electrode units of each row group of the electrode sheet in a one-to-one correspondence. The multiple dual-purpose signal lines electrically connected one by one to the electrode sheet are turned on so that the multiple dual-purpose signal lines electrically connected to the electrode sheet transmit AC signals to each electrode unit; the process of making each electrode unit of the electrode sheet transmit a temperature detection signal includes the following steps: the multiple dual-purpose signal lines electrically connected one by one to the electrode units of each row group of the electrode sheet are connected to DC signals separately in sequence; and one of the multiple grounding lines electrically connected one by one to the electrode units of each column group of the electrode sheet is turned on in sequence so as to complete the transmission of the temperature detection signals of each electrode unit of the electrode sheet row by row through the multiple dual-purpose signal lines electrically connected to the electrode sheet.

[0025] Furthermore, during the process of applying alternating current signals to the electrode units of the electrode sheet, the row group to which the electrode unit to which the alternating current signal needs to be applied is determined according to the area where the electrode unit is located, and the alternating current signal is transmitted to the corresponding dual-purpose signal line electrically connected to the electrode unit in the row group, and the other dual-purpose signal lines stop transmitting the alternating current signal.

[0026] The above description is only an overview of the technical solution of the present application. In order to more clearly understand the technical means of the present application, it can be implemented in accordance with the contents of the specification. In order to make the above and other purposes, features and advantages of the present application more obvious and easy to understand, the specific implementation methods of the present application are listed below. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 is a schematic diagram of the tumor electric field treatment system of the present application, wherein the electrode sheet of the first embodiment is shown;

[0028] Figure 2 For this application Figure 1 Another schematic diagram of the structure of the electrode sheet of the tumor electric field treatment system shown;

[0029] Figure 3 For this application Figure 1 A schematic diagram of circuit connection between the electrode sheet of the first embodiment of the tumor electric field system and the adapter of the first embodiment;

[0030] Figure 4 for Figure 3 A schematic block diagram of the internal structure of the adapter of the first embodiment;

[0031] Figure 5 For this application Figure 1 A schematic block diagram of the internal structure of an electric field generator of a tumor electric field treatment system is shown;

[0032] Figure 6 Another schematic diagram of the tumor electric field treatment system of the present application, showing the electrode sheet of the second embodiment;

[0033] Figure 7 For this application Figure 6 Two other structural schematic diagrams of the electrode sheet of the tumor electric field treatment system are shown;

[0034] Figure 8 For this application Figure 6 A schematic diagram of circuit connection between the electrode sheet of the second embodiment of the tumor electric field treatment system and the adapter of the second embodiment;

[0035] Fig. 9 for Figure 8 A schematic block diagram of the internal structure of the adapter of the second embodiment shown;

[0036] Fig.10 For this application Figure 6 A schematic diagram of circuit connection between the electrode sheet of the third embodiment of the tumor electric field treatment system and the adapter of the third embodiment;

[0037] Fig.11 For this application Figure 6A schematic diagram of circuit connection between the electrode sheet of the fourth embodiment of the tumor electric field treatment system and the adapter of the third embodiment;

[0038] Fig.12 for Fig.10 and Fig.11 A schematic block diagram of the internal structure of the adapter of the third embodiment shown;

[0039] Fig.13 is another schematic diagram of the tumor electric field treatment system of the present application, showing the electrode sheet of the fifth embodiment;

[0040] Fig.14 For this application Fig.13 A schematic diagram of circuit connection between the electrode sheet of the fifth embodiment of the tumor electric field treatment system and the adapter of the fourth embodiment;

[0041] Fig.15 for Fig.14 A schematic block diagram of the internal structure of the adapter of the fourth embodiment shown;

[0042] Fig.16 For this application Fig.13 A schematic diagram of circuit connection between the electrode sheet of the sixth embodiment of the tumor electric field treatment system and the adapter of the fifth embodiment;

[0043] Fig.17 for Fig.14 A schematic block diagram of the internal structure of the adapter of the fifth embodiment shown;

[0044] Fig.18 A schematic flow chart of a temperature detection method of a tumor electric field therapy system according to an embodiment of the present application;

[0045] Fig.19 A schematic flow chart of a method for controlling application of an alternating current signal for electric field therapy of tumors according to an embodiment of the present application;

[0046] Fig. 20 A schematic flow chart of a signal control method for tumor electric field therapy according to an embodiment of the present application;

[0047] Fig.21 A schematic flow chart of a method for applying an alternating current signal for electric field therapy of tumors according to another embodiment of the present application;

[0048] Fig. 22 A schematic flow chart of a method for applying an alternating current signal based on a temperature detection signal according to an embodiment of the present application;

[0049] Fig.23 It is a flowchart of a method for applying an alternating current signal based on a temperature detection signal according to another embodiment of the present application.

[0050] Description of reference numerals:

[0051] Tumor electric field treatment system 100, electrode sheet 10, 10A, 10B, 10C, 10D, 10E, flexible circuit board 11, 11A, 11B, 11C, 11D, 11E, connection part 111, connection part 112, bridge part 113, electrode unit 12, first cable 13, temperature sensor 14, ground terminal 14-1, signal terminal 14-2, dielectric element 15, diode 16, ground wire 18, first ground wire 18-1, second ground wire 18-2, third ground wire 18-3, fourth ground wire 18-4, dual-purpose signal wire 19, first dual-purpose signal wire 19-1, second dual-purpose signal wire 19-2, third dual-purpose signal wire 19-3, fourth dual-purpose signal wire 19-4, fifth dual-purpose signal wire 19-5, adapter 20, 20A, 20B, 20D, 20E, second cable 21, first control Controller 22, analog-to-digital converter 23, voltage-dividing resistor 24, grounding switch 25, first grounding switch 25-1, second grounding switch 25-2, third grounding switch 25-3, fourth grounding switch 25-4, bidirectional switch 26, first bidirectional switch 26-1, second bidirectional switch 26-2, third bidirectional switch 26-3, fourth bidirectional switch 26-4, fifth bidirectional switch 26-5, first communication unit 27, AC signal line 28, first power module 29, electric field generator 30, second power module 31, second controller 32, second communication unit 33, AC signal generator 34, AC signal switch 35, first connector 40, 40A, 40B, 40D, 40E, first plug 41, first socket 42, second connector 50, second plug 51, second socket 52. DETAILED DESCRIPTION

[0052] The following embodiments of the technical solution of the present application are described in detail in conjunction with the accompanying drawings. The following embodiments are only used to more clearly illustrate the technical solution of the present application, and are therefore only used as examples, and cannot be used to limit the scope of protection of the present application.

[0053] Figure 1 FIG. 1 is a schematic diagram of a tumor electric field treatment system 100 of the present application. Figure 1As shown, the tumor electric field treatment system 100 includes: at least one pair of electrode sheets 10, an adapter 20 connected to the electrode sheets 10, and an electric field generator 30 connected to the adapter 20. The electric field generator 30 supplies power to the electrode sheets 10 so that the electrode sheets 10 generate an alternating current signal. The adapter 20 is electrically connected between the electrode sheets 10 and the electric field generator 30, and is used to transmit the alternating current signal generated by the electric field generator 30 to the electrode sheets 10. In other words, the electric field generator 30 is capable of generating an alternating current signal, and the generated alternating current signal is transmitted to each electrode sheet 10 through the adapter 20, so that an alternating electric field for treating tumors is generated between the corresponding pair of electrode sheets 10. As shown in FIG. Figure 1 As shown, in this embodiment, the number of electrode sheets 10 is 4. Each electrode sheet 10 includes a plurality of electrode units 12 of the same number, and each electrode unit 12 is electrically connected to the adapter 20. The number of electrode units 12 on each electrode sheet 10 is 20. In other embodiments, the tumor electric field treatment system 100 may also have more or fewer electrode sheets 10. In other embodiments, each pair of electrode sheets 10 has the same number of electrode units 12, and different pairs of electrode sheets 10 may also have different numbers of electrode units 12.

[0054] Figure 3 FIG. 1 is a schematic diagram of the circuit connection between the electrode sheet 10 and the adapter 20 of the tumor electric field treatment system 100. It is worth noting that: Figure 3 The arrangement of the electrode units 12 shown is to more clearly illustrate the electrical connection between an electrode sheet 10 and an adapter 20. Figure 3 The arrangement of the electrode units 12 shown does not represent the arrangement of the electrode units 12 in a spatial structure. Figure 1 as well as Figure 3 The electrode sheet 10 includes: a flexible circuit board 11, a plurality of electrode units 12 electrically connected to the flexible circuit board 11 at intervals, and a first cable 13 electrically connected to the flexible circuit board 11. The flexible circuit board 11 is embedded with multiple conductive traces (18, 19), and the multiple conductive traces (18, 19) include multiple grounding wires 18 and multiple dual-purpose signal wires 19. The first cable 13 has multiple core wires (not shown), and each core wire is electrically connected to the multiple grounding wires 18 and the multiple dual-purpose signal wires 19 of the flexible circuit board 11 in a one-to-one correspondence. The total number of grounding wires 18 and dual-purpose signal wires 19 embedded in the flexible circuit board 11 does not exceed 10. Therefore, the number of wires of the first cable 13 does not exceed 10.

[0055] In the present embodiment, each electrode sheet 10 is provided with 20 electrode units 12, and the 20 electrode units 12 are arranged in the order of 1 to 20 in the circuit connection, and are divided into four row groups and five column groups, that is, the 20 electrode units 12 are arranged in four rows and five columns in the circuit connection. Each electrode unit 12 includes: a dielectric element 15 and a temperature sensor 14. The temperature sensor 14 includes a ground terminal 14-1 and a signal terminal 14-2. The dielectric element 15 and the temperature sensor 14 are both soldered to the flexible circuit board 11, and the dielectric element 15 is short-circuited with the signal terminal 14-2 of the corresponding temperature sensor 14. Since a plurality of temperature sensors 14 are arranged one-to-one with a plurality of electrode units 12, the plurality of temperature sensors 14 are also arranged in four row groups and five column groups in the circuit connection. It should be noted that the arrangement here is to more clearly show the electrical connection between the electrode sheet 10 and the adapter 20, and does not represent the arrangement of the electrode unit 12 in the spatial structure, and its spatial structure may be as follows Figure 1 The structure shown is roughly an array, but may also be other structures, such as petal-shaped or scattered, etc., and may be a regular or irregular structure.

[0056] The dielectric element 15 is configured to apply an alternating electric field to the tumor site of the patient. Multiple temperature sensors 14 located in the same row group are connected in series, and a signal terminal 14-2 located at the end of each row group is connected to the DC power supply VCC through a bidirectional switch 26 and a voltage divider resistor 24 connected in series. After the ground terminals 14-1 of the corresponding temperature sensors 14 in each column group are connected together, they are connected to the ground pin GND through a ground switch 25. The total number of bidirectional switches 26 and ground switches 25 does not exceed 9, so that the switching timing of the bidirectional switch 26 and the ground switch 25 is configured so that the temperature detection signals detected by the corresponding one or more combinations of all the temperature sensors 14 of the electrode sheet 10 are sampled respectively. In this embodiment, the multiplexed signal lines 19 of the flexible circuit board 11 are respectively arranged in one-to-one correspondence with the multiple row groups of the electrode units 12, and are configured to transmit the alternating current signal generated by the electric field generator 30 to the dielectric element 15 in each electrode unit 12 in the corresponding column group. The dielectric elements 15 in the same row group are connected in series to the same dual-purpose signal line 19 of the flexible circuit board 11, and the dielectric elements 15 in different row groups are connected in parallel through different dual-purpose signal lines 19 of the flexible circuit board 11. The dual-purpose signal line 19 of the flexible circuit board 11 is electrically connected to the first cable 13, and then electrically connected to the electric field generator 30 via the adapter 20. Further, the dual-purpose signal line 19 of the flexible circuit board 11 receives the alternating current signal generated by the electric field generator 30 through the first cable 13 and the adapter 20.

[0057] The multiple grounding wires 18 are respectively arranged in one-to-one correspondence with the multiple column groups of the electrode unit 12, and the multiple grounding wires 18 are respectively used to short-circuit the temperature sensor 14 of each electrode unit 12 corresponding to each column group to the ground. That is, the grounding ends 14-1 of the multiple temperature sensors 14 in the same column group are short-circuited through the same grounding wire 18 of the flexible circuit board 11, and the grounding ends 14-1 of the temperature sensors 14 in different column groups are respectively connected in parallel through different grounding wires 18 of the flexible circuit board 11. During the time period of temperature detection, only one of the multiple grounding wires 18 is turned on at the same time, and the other wires are disconnected. In this embodiment, the external device for receiving the detection signal is an adapter 20. The grounding ends 14-1 of the multiple temperature sensors 14 in different column groups are respectively connected in parallel through different grounding wires 18 of the flexible circuit board 11, and the grounding ends 14-1 of the multiple temperature sensors 14 in the same column group are respectively connected to the same grounding wire 18 of the flexible circuit board 11.

[0058] In this embodiment, when each electrode unit 12 is equipped with a temperature sensor 14 for temperature detection, the above-mentioned circuit design is used to reduce the number of wires of the first cable 13, so as to avoid the cable becoming thicker and the cable becoming harder, thereby increasing the difficulty of fixing the cable; at the same time, the increase in the number of wires of the first cable 13 is avoided to affect the adhesion effect between the electrode sheet 10 and the corresponding body surface of the patient's tumor site. The ground wire 18 and the dual-purpose signal wire 19 embedded in the flexible circuit board 11 are 9 lines in total. Specifically, in this embodiment, the ground wire 18 embedded in the flexible circuit board 11 is 5 lines, and the dual-purpose signal wire 19 is 4 lines. In other embodiments, the ground wire 18 and the dual-purpose signal wire 19 embedded in the flexible circuit board 11 can also have other numbers according to the circuit arrangement and quantity difference of the electrode unit 12 in different electrode sheets, which will be specifically described in subsequent embodiments. In the tumor electric field treatment system 100, the number of conductive lines electrically connected to the ground wire 18 is related to the number of column groups M of the electrode unit 12, which can be greater than or equal to the number of column groups of the electrode unit 12, and M is a positive integer. The number of conductive lines electrically connected to the dual-purpose signal lines 19 in the tumor electric field treatment system 100 is related to the number of row groups N of the electrode unit 12, which is greater than or equal to the number of row groups of the electrode unit 12, and N is a positive integer. The number of lines L embedded in the flexible circuit board 11 of the electrode sheet 10 is equal to the sum of the number of grounding lines 18 and the number of dual-purpose signal lines 19. In this embodiment, the number of grounding lines 18 is equal to the number of column groups M of the electrode unit 12; the dual-purpose signal lines 19 are equal to the number of row groups N of the electrode unit 12.

[0059] The plurality of electrode units 12 are arranged on the flexible circuit board 11 in a two-dimensional array. Figure 1As shown, the electrode sheet 10 in this embodiment includes 20 electrode units 12 and 20 temperature sensors 14 corresponding to the electrode units 12. The 20 electrode units 12 are arranged in an array of four rows and six columns. The first row and the fourth row each have four electrode units 12, and the second row and the third row each have six electrode units 12. The four electrode units 12 in each of the first row and the fourth row are located in each of the second to fifth columns, and the six electrode units 12 in each of the second row and the third row are located in each of the first to sixth columns. The flexible circuit board 11 is provided with a plurality of connecting portions 111 connecting two adjacent electrode units 12, a wiring portion 112 connected to the first cable 13, and a bridging portion 113 connected to the wiring portion 112. The bridging portion 113 connects two connecting portions 111 arranged opposite and in parallel. The 20 electrode units can be divided into a left part including three columns on the left and a right part including three columns on the right. The left part and the right part are connected only by a bridging portion 113, that is, along the row upward, there is no connecting portion 111 between the electrode unit 12 located in the third column and the adjacent electrode unit 12 located in the fourth column, but a gap D1 is formed; and along the column upward, only the adjacent two electrode units 12 in the third column and the fourth column are connected by the connecting portion 111, and the adjacent two electrode units 12 in the other four columns are not connected by the connecting portion 111 but a gap D2 is formed. The setting of the gaps D1 and D2 can increase the degree of freedom of some electrode units 12, and can avoid wrinkles when attaching the electrode sheet 10. Figure 2 It is an electrode sheet 10' of another structure, the difference is that the bridge portion 113' connected to the electrode sheet 10' and the wiring portion 112 connects between two electrode units 12 arranged oppositely. In addition, along the column upward, only the adjacent two electrode units 12 in the third and fifth columns of the electrode sheet 10' are connected by the connecting portion 111, and the adjacent two electrode units 12 in the other four columns are not connected by the connecting portion 111 but form a gap D2. Along the row upward, there is also no connecting portion 111 between the electrode unit 12 in the third column of the electrode sheet 10' and the adjacent electrode unit 12 in the fourth column, but a gap D1 is formed. The setting of the gaps D1 and D2 can increase the degree of freedom of some electrode units 12, and wrinkles can be avoided when attaching the electrode sheet 10. In some other embodiments, the 20 electrode units 12 can also be arranged in other ways. Of course, in some other embodiments, the electrode sheet 10 can also have other numbers of electrode units 12. In short, the implementation of the present application is not limited by the number and arrangement of the electrode units 12 of the electrode sheet 10.

[0060] Each electrode unit 12 includes a dielectric element 15 and a temperature sensor 14. Figure 3In the illustrated embodiment, the dielectric element 15 may be a dielectric ceramic sheet or a polymer dielectric layer composed of a polymer material. The temperature sensor 14 may be a thermistor element. Of course, in other embodiments, the temperature sensor 14 may also be a temperature sensor other than a thermistor, which may be disposed at any position on the electrode unit 12. In the present embodiment, each dielectric element 15 has a through hole (unnumbered) extending through the middle thereof, and a corresponding temperature sensor 14 is accommodated in the through hole (unnumbered) of each dielectric element 15. Each electrode unit 12 may further include a diode 16. The diode 16 is connected in series with the temperature sensor 14 of the same electrode unit 12, and it may prevent the reverse inflow of current to prevent the detection signal from other electrode units 12 from affecting the temperature sensor 14.

[0061] Ginseng Figure 3 As shown, the electrode sheet 10 of this embodiment includes 4 dual-purpose signal lines 19, one end of each dual-purpose signal line 19 is respectively connected to all electrode units 12 in each row group, and the other end thereof is connected to an adapter 20 for receiving temperature detection signals and transmitting alternating current signals. Specifically, the 4 dual-purpose signal lines 19 of the electrode sheet 10 include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, a third dual-purpose signal line 19-3, and a fourth dual-purpose signal line 19-4. In the 4 row groups of the electrode sheet 10, the first row group includes electrode units 12-1 to 12-5, the second row group includes electrode units 12-6 to 12-10, the third row group includes electrode units 12-11 to 12-15, and the fourth row group includes electrode units 12-16 to 12-20. Specifically, the first dual-purpose signal line 19-1 is connected in series with the electrode unit 12-1 to the electrode unit 12-5 in the first row group; the second dual-purpose signal line 19-2 is connected in series with the electrode unit 12-6 to the electrode unit 12-10 in the second row group; the third dual-purpose signal line 19-3 is connected in series with the electrode unit 12-11 to the electrode unit 12-15 in the third row group; the fourth dual-purpose signal line 19-4 is connected in series with the electrode unit 12-16 to the electrode unit 12-20 in the fourth row group. In short, each dual-purpose signal line 19 connects the dielectric elements 15 of the electrode units 12 and the signal ends 14-2 of the temperature sensors 14 in the same row group in series and is used to connect to the adapter 20. It should be noted that these dual-purpose signal lines 19 can selectively transmit AC signals or receive temperature detection signals, which can be achieved by connecting each dual-purpose signal line 19 in series with a bidirectional switch 26 and coordinating the closing or opening of the ground line 18, which will be described in detail below.

[0062] The electrode sheet 10 of this embodiment includes 5 grounding wires 18, each of which is used to ground the grounding terminals 14-1 of the temperature sensors 14 of the same column group. That is, for each column group, each grounding wire 18 can be connected to one of the electrode units 12 or not connected to any of the electrode units 12 in the column group to avoid subsequent output of duplicate signals. The 5 grounding wires 18 of the electrode sheet 10 are respectively a first grounding wire 18-1, a second grounding wire 18-2, a third grounding wire 18-3, a fourth grounding wire 18-4, and a fifth grounding wire 18-5. One end of the first grounding wire 18-1 is connected to the dielectric elements 15 of the four electrode units 12, namely, electrode unit 12-1, electrode unit 12-6, electrode unit 12-11 and electrode unit 12-16, and the grounding end 14-1 of the temperature sensor 14; one end of the second grounding wire 18-2 is connected to the dielectric elements 15 of the four electrode units 12, namely, electrode unit 12-2, electrode unit 12-7, electrode unit 12-12 and electrode unit 12-17, and the grounding end 14-1 of the temperature sensor 14; one end of the third grounding wire 18-3 is connected to the dielectric elements 15 of the four electrode units 12, namely, electrode unit 12-3, electrode unit 12-8, electrode unit 12-13 and electrode unit 14, and the grounding end 14-1 of the temperature sensor 14 The dielectric elements 15 of the four electrode units 12 of the electrode unit 12-18 and the grounding end 14-1 of the temperature sensor 14; one end of the fourth grounding wire 18-4 is connected to the dielectric elements 15 of the four electrode units 12 of the electrode unit 12-4, the electrode unit 12-9, the electrode unit 12-14 and the electrode unit 12-19 and the grounding end 14-1 of the temperature sensor 14; one end of the fifth grounding wire 18-5 is connected to the dielectric elements 15 of the four electrode units 12 of the electrode unit 12-5, the electrode unit 12-10, the electrode unit 12-15 and the electrode unit 12-20 and the grounding end 14-1 of the temperature sensor 14. It should be noted that these grounding wires 18 can be selectively closed or disconnected, which can be achieved by connecting each grounding wire 18 in series with a switch, which will be described in detail below. The above-mentioned “grounding the electrode unit 12” may refer to grounding the ground terminal 14-1 of the temperature sensor 14 in the electrode unit 12, or may refer to connecting the diode 16 in series with the temperature sensor 14 of the same electrode unit 12 and grounding them together. In short, each grounding line 18 short-circuits the ground terminals 14-1 of the temperature sensors 14 of all the electrode units 12 in each column group and grounds them.

[0063] The multiple grounding wires 18 and the multiplexed signal wires 19 are conductive traces embedded in the flexible circuit board 11. The flexible circuit board 11 is electrically connected to the first cable 13. The multiple grounding wires 18 and the multiplexed signal wires 19 embedded in the flexible circuit board 11 are electrically connected to corresponding wires (not shown) in the first cable 13 one by one.

[0064] The tumor electric field treatment system 100 of this embodiment includes at least one pair of the above-mentioned electrode sheets 10, an adapter 20 electrically connected to the electrode sheets 10, and an electric field generator 30 electrically connected to the adapter 20. The adapter 20 is connected between the electrode sheets 10 and the electric field generator 30. The electric field generator 30 provides an alternating current signal to the dielectric elements 15 in the multiple electrode units 12 of the electrode sheets 10 via the adapter 20 and the dual-purpose signal line 19 of the electrode sheets 10, or is used to receive the temperature detection signal output by the temperature sensor 14 in the multiple electrode units 12. The adapter 20 transmits the alternating current signal generated by the electric field generator 30 to the dual-purpose signal line 19 of the electrode sheets 10, and is also configured to receive the temperature detection signal output by the multiplex dual-purpose signal line 19 of the electrode sheets 10.

[0065] refer to Figure 3 and Figure 4 As shown, the adapter 20 includes: a first controller 22, multiple groups of analog-to-digital converters 23 connected to the first controller 22, multiple groups of pressure resistors 24 corresponding to the multiple groups of analog-to-digital converters 23, multiple groups of grounding switches 25, multiple groups of bidirectional switching switches 26 connected to the multiple groups of analog-to-digital converters 23, a first communication unit 27, an AC signal line 28 connected to each group of bidirectional switching switches 26, and a first power supply module 29 connected to the first communication unit 27, the first controller 22 and the multiple groups of analog-to-digital converters 23. The first power supply module 29 provides a DC power supply VCC for each electronic component of the adapter 20.

[0066] The adapter 20 also includes multiple circuit lines (unnumbered). The multiple circuit lines (unnumbered) are electrically connected to the multiple grounding lines 18 and the multiple dual-purpose signal lines 19 in the flexible circuit board 11 of the corresponding electrode sheet 10 through the first cables 13 of the corresponding electrode sheet 10. The multiple circuit lines (unnumbered) include multiple AC signal lines 28 that transmit AC signals to the corresponding electrode sheet 10 and are electrically connected to the multiple dual-purpose signal lines 19 in the flexible circuit board 11 of the corresponding electrode sheet 10, multiple circuit lines (unnumbered) that are electrically connected to the multiple dual-purpose signal lines 19 in the flexible circuit board 11 of the corresponding electrode sheet 10 and are used to supply power to each temperature sensor 14 of the electrode sheet 10 or transmit the temperature detection signal of the electrode sheet 10, and multiple circuit lines (unnumbered) that are electrically connected to the multiple grounding lines 18 in the flexible circuit board 11 of the corresponding electrode sheet 10. The number of circuit lines L that the adapter 20 electrically connects to an electrode sheet 10 is equal to the sum of the number of rows N and the number of columns M of the electrode units 12 of the electrode sheet 10 plus 1; the number of circuits H that the adapter 20 electrically connects to X electrode sheets 10 is equal to X times the number of circuit lines that it electrically connects to a single electrode sheet 10, that is, H=XL=X*(M+N+1). The number of groups of grounding switches 25 and the number of groups of bidirectional switching switches 26 are both related to the number of electrode sheets 10. The number of groups of grounding switches 25 is the same as the number of groups of bidirectional switching switches 26; and is not less than the number of electrode sheets 10. Preferably, the number of groups of grounding switches 25 and bidirectional switching switches 26 is the same as the number of electrode sheets 10. The following is a detailed description taking only the electrical connection between an electrode sheet 10 having 20 electrode units 12 and an adapter 20 as an example.

[0067] Each group of grounding switches 25 is provided with a plurality of grounding switches 25, which are respectively connected to the adapter 20 and are respectively electrically connected to the circuit lines (not numbered) corresponding to the multi-path grounding lines 18 of the corresponding electrode sheet 10, and are configured to control the conduction or disconnection of the multi-path grounding lines 18. The circuit lines (not numbered) that are electrically connected to the multi-path grounding lines 18 of the electrode sheet 10 are grounded at one end close to the grounding switches 25. The number of grounding switches 25 in each group of grounding switches 25 is related to the number of grounding lines 18 of the flexible circuit board 11 of the corresponding electrode sheet 10, and the two are equal in this embodiment. Figure 3As shown, in this embodiment, each group of grounding switches 25 includes a first grounding switch 25-1, a second grounding switch 25-2, a third grounding switch 25-3, a fourth grounding switch 25-4 and a fifth grounding switch 25-5. Each group of multiple grounding switches 25 controls the closing or opening of the corresponding grounding line 18 of a corresponding electrode sheet 10 one by one. Specifically, the first grounding switch 25-1 is used to control the closing or disconnection of the first grounding line 18-1 of the corresponding electrode sheet 10, and can then cooperate with the corresponding group of two-way switching switches 26 to control the power on and off of each temperature sensor 14 of the four electrode units 12, namely, the electrode unit 12-1, the electrode unit 12-6, the electrode unit 12-11 and the electrode unit 12-16 in the first column group of the electrode sheet 10; the second grounding switch 25-2 is used to control the closing or disconnection of the second grounding line 18-2 of the electrode sheet 10, and can then cooperate with the corresponding group of two-way switching switches 26 to control the power on and off of each temperature sensor 14 of the four electrode units 12, namely, the electrode unit 12-2, the electrode unit 12-7, the electrode unit 12-12 and the electrode unit 12-17 in the second column group of the electrode sheet 10; the third grounding switch 25-3 is used to control the closing or disconnection of the third grounding line 18-3 of the electrode sheet 10, and can then cooperate with the corresponding group of two-way switching switches 26 to control the power on and off of each temperature sensor 14 of the four electrode units 12, namely, the electrode unit 12-2, the electrode unit 12-7, the electrode unit 12-12 and the electrode unit 12-17 in the second column group of the electrode sheet 10 The temperature sensors 14 of the four electrode units 12, namely, electrode unit 12-3, electrode unit 12-8, electrode unit 12-13 and electrode unit 12-18 in the third column group are powered on and off; the fourth grounding switch 25-4 is used to control the closing or disconnection of the fourth grounding line 18-4 of the electrode sheet 10, and can then cooperate with the corresponding group of two-way switching switches 26 to control the power on and off of the temperature sensors 14 of the four electrode units 12, namely, electrode unit 12-4, electrode unit 12-9, electrode unit 12-14 and electrode unit 12-19 in the fourth column group of the electrode sheet 10; the fifth grounding switch 25-5 is used to control the closing or disconnection of the fifth grounding line 18-5 of the electrode sheet 10, and can then cooperate with the corresponding group of two-way switching switches 26 to control the power on and off of the temperature sensors 14 of the four electrode units 12, namely, electrode unit 12-5, electrode unit 12-10, electrode unit 12-15 and electrode unit 12-20 in the fifth column group of the electrode sheet 10. The grounding switch 25 may be a mechanical switch, such as a relay. The grounding switch 25 may also be an electronic switch, and each grounding switch 25 may be opened and closed by an additional first controller 22 .

[0068] In this embodiment, the multiple groups of grounding switches 25 are all electronic switches. The first controller 22 is connected to the multiple groups of grounding switches 25 for sequentially and cyclically controlling the opening and closing states of multiple grounding switches 25 in each group of grounding switches 25, and then sequentially and individually conducting each of the multiple grounding wires 18 of the corresponding electrode sheet 10 and cooperating with the switching of the corresponding bidirectional switch 26, so as to continuously and in real time collect the temperature of the patient's body surface detected by all temperature sensors 14 on the electrode sheet 10. The number of switches in each group of grounding switches 25 is equal to the number of grounding wires 18 of the flexible circuit board 11 of the corresponding electrode sheet 10.

[0069] Each group of two-way switching switches 26 is provided with a plurality of two-way switching switches 26, and the plurality of two-way switching switches 26 in each group are respectively connected to the adapter 20 and are respectively electrically connected to the circuit lines (not numbered) corresponding to the multi-channel dual-purpose signal lines 19 of the corresponding electrode sheet 10. The number of two-way switching switches 26 in each group of two-way switching switches 26 is related to the number of dual-purpose signal lines 19 of the flexible circuit board 11 of the corresponding electrode sheet 10, which is greater than or equal to the number of dual-purpose signal lines 19 of the flexible circuit board 11 of the corresponding electrode sheet 10, and the two are equal in this embodiment. Each two-way switching switch 26 has two ends marked as 1 and 2, and the first ends of the plurality of two-way switching switches 26 in the same group are respectively electrically connected to the corresponding detection channels in the plurality of detection channels of the corresponding group of analog-to-digital converters 23, and the second ends of each two-way switching switch 26 in the same group are electrically connected to the corresponding same AC signal line 28. Each bidirectional switch 26 is configured to control the multiplex signal line 19 to access the corresponding AC signal line 28 to transmit an alternating current signal or to access the corresponding detection channel of the corresponding group of analog-to-digital converters 23 to receive the temperature detection signal output by the temperature sensor 14 .

[0070] like Figure 3As shown, taking an electrode sheet 10 electrically connected to an adapter 20 as an example, in this embodiment with 20 electrode units 12, the plurality of bidirectional switches 26 are respectively a first bidirectional switch 26-1, a second bidirectional switch 26-2, a third bidirectional switch 26-3 and a fourth bidirectional switch 26-4. The plurality of bidirectional switches 26 in the same group respectively control the switching of a corresponding one of the multiplexed dual-purpose signal lines 19 of the same electrode sheet 10 between transmitting an alternating current signal and transmitting a temperature detection signal. Specifically, the first bidirectional switch 26-1 is used to control the switching of the first dual-purpose signal line 19-1 of the corresponding electrode sheet 10 between transmitting an alternating current signal and transmitting a temperature detection signal, thereby controlling the switching between the conduction of each dielectric element 15 of the electrode unit 12-1 to the electrode unit 12-5 in the first row group of the electrode sheet 10 and the conduction of the signal end 14-2 of each temperature sensor 14 of the electrode unit 12-1 to the electrode unit 12-5 in the first row group, and cooperating with the corresponding first grounding switch 25-1, the second grounding switch 25-2, the third grounding switch 25-3, the fourth grounding switch 25-4, and the fifth grounding switch 25-5, so that the first row of electrode units 12-1 to the electrode unit 12-5 transmit an alternating current signal to the patient or output the temperature detection signal collected by the temperature sensor 14 of these electrode units 12 to the corresponding analog-to-digital converter 23. The second bidirectional switch 26-2 is used to control the switching of the second dual-purpose signal line 19-2 of the corresponding electrode sheet 10 between transmitting an alternating current signal and transmitting a temperature detection signal, thereby controlling the switching between the conduction of the dielectric elements 15 of the electrode unit 12-6 to the electrode unit 12-10 in the second row group of the electrode sheet 10 and the conduction of the signal end 14-2 of the temperature sensor 14 of the electrode unit 12-6 to the electrode unit 12-10 in the second row group, and cooperating with the corresponding first grounding switch 25-1, the second grounding switch 25-2, the third grounding switch 25-3, the fourth grounding switch 25-4 and the fifth grounding switch 25-5, so that the second row electrode unit 12-6 to the electrode unit 12-10 transmits an alternating current signal to the patient or outputs the temperature detection signal collected by the temperature sensor 14 of the electrode units 12 to the corresponding analog-to-digital converter 23;The third bidirectional switch 26-3 is used to control the switching of the third dual-purpose signal line 19-3 of the corresponding electrode sheet 10 between transmitting an alternating current signal and transmitting a temperature detection signal, thereby controlling the switching between the conduction of each dielectric element 15 of the electrode unit 12-11 to the electrode unit 12-15 in the third row group of the electrode sheet 10 and the conduction of the signal end 14-2 of each temperature sensor 14 of the electrode unit 12-11 to the electrode unit 12-15 in the third row group, and cooperating with the corresponding first grounding switch 25-1, the second grounding switch 25-2, the third grounding switch 25-3, the fourth grounding switch 25-4 and the fifth grounding switch 25-5, so that the third row of electrode units 12-11 to the electrode unit 12-15 transmit an alternating current signal to the patient or output the temperature collected by the temperature sensors 14 of these electrode units 12 to the corresponding analog-to-digital converter 23. The fourth bidirectional switch 26-4 is used to control the switching of the fourth dual-purpose signal line 19-4 of the corresponding electrode sheet 10 between transmitting AC signals and transmitting temperature detection signals, thereby controlling the conduction of the dielectric elements 15 of the electrode units 12-16 to the electrode units 12-20 in the fourth row group of the electrode sheet 10 and the conduction of the signal ends 14-2 of the temperature sensors 14 of the electrode units 12-16 to the electrode units 12-20 in the fourth row group, and cooperating with the corresponding first grounding switch 25-1, the second grounding switch 25-2, the third grounding switch 25-3, and the fourth grounding switch 25-4, so that the fourth row of electrode units 12-16 to the electrode units 12-20 transmit AC signals to the patient or output the temperature detection signals collected by the temperature sensors 14 of the electrode units 12 to the corresponding analog-to-digital converter 23. When the second end of each group of two-way switching switches 26 is turned on and the first end is turned off, and the corresponding group of grounding switches 25 are all turned off, an AC signal can be transmitted to the dielectric element 15 of each electrode unit 12 of the corresponding electrode sheet 10. When the first end of each group of two-way switching switches 26 is turned on and the second end is turned off, it can cooperate with each grounding switch 25 in the corresponding group of grounding switches 25 to transmit the temperature detection signal collected by the temperature sensor 14 of each electrode sheet 10 on the electrode sheet 10 in a time-sharing manner. The above-mentioned two-way switching switch 26 can be a mechanical switch, such as a relay. The two-way switching switch 26 can also be an electronic switch, and each two-way switching switch 26 can be switched by an additional first controller 22. ;

[0071] In this embodiment, the plurality of sets of two-way switches 26 are all electronic switches. The first controller 22 is in communication connection with the plurality of sets of two-way switches 26, and is used to control the plurality of two-way switches 26 in each set of two-way switches 26 to switch between their respective first ends and second ends, and to cooperate with the closing or opening of the corresponding grounding switch 25, so as to continuously monitor the temperature of the patient's body surface detected by all the temperature sensors 14 on the electrode sheet 10 or transmit an AC signal to the patient.

[0072] In the present embodiment, each group of analog-to-digital converters 23 is electrically connected one by one to the first ends of the plurality of bidirectional switching switches 26 in the corresponding group of bidirectional switching switches 26 through the multi-channel circuit lines (unnumbered) in the adapter 20, and is configured to receive the temperature detection signal transmitted by the multi-channel dual-purpose signal line 19 of the corresponding electrode sheet 10, and convert the temperature detection signal from an analog signal to a digital signal. Each group of analog-to-digital converters 23 includes a plurality of detection channels A, B, C, and D, and each detection channel A, B, C, and D is used to connect a corresponding one-channel dual-purpose signal line 19 in the multi-channel dual-purpose signal line 19 through the corresponding bidirectional switching switch 26. The number of detection channels in each group of analog-to-digital converters 23 is related to the number of bidirectional switching switches 26 in the corresponding group. The number of detection channels in each group of analog-to-digital converters 23 is related to the number of row groups of the electrode units 12 of the corresponding electrode sheet 10. Specifically, the number of detection channels in each group of analog-to-digital converters 23 is equal to the number of bidirectional switching switches 26 in the group of bidirectional switching switches 26 corresponding thereto, which is not less than the number of row groups of the electrode units 12 of the corresponding electrode sheet 10. As Figure 3 As shown, each group of analog-to-digital converters 23 includes a total of 4 detection channels A, B, C, and D, which are the first detection channel A, the second detection channel B, the third detection channel C, and the fourth detection channel D. The first detection channel A is connected to the first dual-purpose signal line 19-1 through the first end of the first two-way switch 26-1, the second detection channel B is connected to the second dual-purpose signal line 19-2 through the first end of the second two-way switch 26-2, the third detection channel C is connected to the third dual-purpose signal line 19-3 through the first end of the third two-way switch 26-3, and the fourth detection channel D is connected to the fourth dual-purpose signal line 19-4 through the first end of the fourth two-way switch 26-4. Each detection channel A, B, C, and D is used to receive the temperature detection signal collected by the temperature sensor 14 of the electrode unit 12 to which the corresponding dual-purpose signal line 19 is connected. In addition, each detection channel A, B, C, and D is connected to the first power module 29 for providing detection voltage to the detection channel A, B, C, and D through a corresponding voltage divider resistor 24 in the adapter 20, and the first power module 29 provides direct current.

[0073] In this embodiment, the first communication unit 27 is configured to obtain the digital signals output by the multiple analog-to-digital converters 23 and send the digital signals to the electric field generator 30. The electric field generator 30 is also configured to control and adjust the voltage, current or power of the AC signal provided to the multiple electrode units 12 of the electrode sheet 10 according to the received digital signals. Exemplarily, when any of the multiple digital signals received exceeds the preset threshold value, it means that the temperature of the human body surface to which the corresponding dielectric element 15 is attached detected by at least one temperature sensor 14 in the electrode sheet 10 exceeds the preset threshold temperature (for example, 41°C, 42°C, etc.), and at this time, the voltage, current or power of the AC signal output by the electric field generator 30 can be appropriately reduced to avoid the electrode unit 12 of the electrode sheet 10 from being too high when the AC signal is applied, causing low-temperature burns to the patient's skin. The above-mentioned preset threshold temperature and preset threshold value can be determined according to the human safety threshold value. The first communication unit 27 is controlled by the first controller 22 and transmits the digital signals converted by the multiple analog-to-digital converters 23 in series. In this embodiment, the preset temperature threshold value can be a value within 36°C-45°C.

[0074] refer to Figure 3 and Figure 4 As shown, in this embodiment, the first power module 29 is electrically connected to the second power module 31 of the electric field generator 30, and is configured to supply power to the first controller 22, the multiple analog-to-digital converters 23, and the first communication unit 27 of the adapter 20. A first connector 40 is connected between each electrode sheet 10 and the adapter 20, and the first connector 40 is suitable for connecting the corresponding electrode sheet 10 to the adapter 20. Figure 1 As shown, the first connector 40 includes a first plug 41 provided at an end of the first cable 13 away from the electrode sheet 10 and a first socket 42 provided on the adapter 20. The first plug 41 and the first socket 42 are push-type spring connectors, that is, the first connector 40 uses a connector to connect the adapter 20 with the electrode sheet 10. Each first cable 13 has four wires electrically connected to the two-way switch 26-1, 26-2, 26-3, and 26-4 in the corresponding group of two-way switch 26, and five wires electrically connected to the grounding switch 25-1, 25-2, 25-3, 25-4, and 25-5 in the corresponding group of grounding switch 25. That is, each first connector 40 is electrically connected to a corresponding group of two-way switch 26 and a corresponding group of grounding switch 25 of the adapter 20 through nine wires; and is connected to the electric field generator 30 through a corresponding AC signal line 28 of the adapter 20.

[0075] A second connector 50 is provided between the adapter 20 and the electric field generator 30, and the second connector 50 is suitable for connecting the electric field generator 30 to the adapter 20. The adapter 20 also includes a second cable 21 connected to the second connector 50. The second connector 50 includes a second plug 51 provided at an end of the second cable 21 away from the first controller 22 and a second socket 52 provided on the electric field generator 30. The second plug 51 and the second socket 52 are press-type spring connectors, that is, the second connector 50 uses a connector to connect the adapter 20 to the electric field generator 30. Each first connector 40, such as X1, Y1, X2 and Y2, is connected to the second connector 50 through a corresponding AC signal line 28, and the first connector 40, such as X1, Y1, X2 and Y2, is also connected to a corresponding set of grounding switches 25 and a corresponding set of analog-to-digital converters 23, wherein each first connector 40 is connected to the second connector 50 and a corresponding set of analog-to-digital converters 23 through a corresponding set of bidirectional switching switches 26. The second cable 21 has 8 conductors, including 4 conductors 1 to 4 which are electrically connected to the corresponding AC signal lines 28 and used to transmit alternating current signals, a conductor 5 which is electrically connected to the data receiving line RX of the first communication unit 27, a conductor 6 which is electrically connected to the data sending line TX of the first communication unit 27, a conductor 7 which is electrically connected to the VCC power line of the first power module 29, and a conductor 8 which is electrically connected to the GND line of the first power module 29.

[0076] The second connector 50 is connected to the first communication unit 27 via a data receiving line RX and a data sending line TX, the VCC pin of the second connector 50 is connected to the VVC power line of the first power module 29, the GND pin of the second connector 50 is connected to the GND line of the first power module 29 and grounded, and the VCC pin of the second connector 50 is also connected to a corresponding group of voltage dividers 24 and a corresponding group of analog-to-digital converters 23 via the VCC power line of the first power module 29.

[0077] refer to Figure 5The electric field generator 30 includes: a second power module 31, a second controller 32, an AC signal generator 34, a second communication unit 33 and a set of AC signal switches 35. The VCC pin of the second connector 50 is also electrically connected to the VCC power line of the second power module 31, and the GND pin of the second connector 50 is grounded through the GND line of the second power module 31. The second power module 31 is also connected to the second controller 32 and the AC signal generator 34 respectively and supplies power to them. The second communication unit 33 is electrically connected to the wire 5 of the second connector 50 through its data receiving line RX and is electrically connected to the wire 6 of the second connector 50 through its data sending line TX, thereby realizing information interaction between the electric field generator 30 and the adapter 20. The second controller 32 is also electrically connected to the second communication unit 33, the AC signal generator 34 and a group of AC signal switches 35. The second controller 32 is configured to control the opening and closing of each AC signal switch 35 in the group of AC signal switches 35 and adjust the relevant parameters of the AC signal applied by the AC signal generator 34 according to the relevant digital signal received by the second communication unit 33 from the adapter 20. The AC signal generator 34 is electrically connected to the wires 1 to 4 for transmitting the AC signal of the second connector 50 through a group of AC signal switches 35. A group of AC signal switches 35 includes a plurality of AC signal switches 35, and the plurality of AC signal switches 35 are arranged in a one-to-one correspondence with the plurality of electrode sheets 10. Each AC signal switch 35 is electrically connected to a corresponding wire 1, 2, 3, 4 for transmitting the AC signal in the second connector 50 through an AC signal connection 36-1, 36-2, 36-3, 36-4 and is electrically connected to the corresponding electrode sheet 10 through the corresponding wires 1, 2, 3, 4 of the second connector 50, so as to transmit the AC signal to each electrode sheet 10. The AC signal generator 34 is electrically connected to the group of AC signal switches 35 through a group of AC signal wirings 36. Specifically, the number of AC signal switches 35 of the electric field generator 30 is related to the number of electrode sheets 10. In this embodiment, the number of AC signal switches 35 is equal to the number of electrode sheets 10 and both are 4. The AC signal switches 35 include a first AC signal switch 35-1, a second AC signal switch 35-2, a third AC signal switch 35-3, and a fourth AC signal switch 35-4, which are electrically connected to the wires 1 to 4 of the second connector 50 in a one-to-one correspondence.One end of the first AC signal switch 35-1 is electrically connected to the AC signal generator 34 through the AC signal connection 36 of the electric field generator 30, and the other end is electrically connected to the corresponding wire 1 for transmitting AC signals in the second connector 50 through an AC signal connection 36-1, and is electrically connected to the AC signal line 28 at the port X1 of the adapter 20 through the wire 1 of the second connector 50, the AC signal line 28 at the port X1 of the adapter 20 is electrically connected to the first connector 40, and the first connector 40 at the port X1 of the adapter 20 is electrically connected to the corresponding electrode sheet 10, so as to control whether the AC signal generator 34 transmits an AC signal to the electrode sheet 10 electrically connected to the port X1 of the adapter 20; One end of the second AC signal switch 35-2 is electrically connected to the AC signal generator 34 through the AC signal connection 36 of the electric field generator 30, and the other end is electrically connected to the corresponding wire 2 for transmitting AC signals in the second connector 50 through an AC signal connection 36-2 and is electrically connected to the AC signal line 28 at the port Y1 of the adapter 20 through the wire 2 of the second connector 50, the AC signal line 28 at the port Y1 of the adapter 20 is electrically connected to the first connector 40, and the first connector 40 at the port Y1 of the adapter 20 is electrically connected to the corresponding electrode sheet 10, so as to control whether the AC signal generator 34 transmits an AC signal to the electrode sheet 10 electrically connected to the port Y1 of the adapter 20; One end of the third AC signal switch 35-3 is electrically connected to the AC signal generator 34 through the AC signal connection 36 of the electric field generator 30, and the other end is electrically connected to the corresponding wire 3 for transmitting AC signals in the second connector 50 through an AC signal connection 36-3, and is electrically connected to the AC signal line 28 at the port X2 of the adapter 20 through the wire 3 of the second connector 50, the AC signal line 28 at the port X2 of the adapter 20 is electrically connected to the first connector 40, and the first connector 40 at the port X2 of the adapter 20 is electrically connected to the corresponding electrode sheet 10, so as to control whether the AC signal generator 34 transmits an AC signal to the electrode sheet 10 electrically connected to the port X2 of the adapter 20; One end of the fourth AC signal switch 35-4 is electrically connected to the AC signal generator 34 through the AC signal connection 36 of the electric field generator 30, and the other end is electrically connected to the corresponding conductor 4 for transmitting AC signals in the second connector 50 through an AC signal connection 36-4 and electrically connected to the AC signal line 28 at the port Y2 of the adapter 20 through the conductor 4 of the second connector 50, the AC signal line 28 at the port Y2 of the adapter 20 is electrically connected to the first connector 40, and the first connector 40 at the port Y2 of the adapter 20 is electrically connected to the corresponding electrode sheet 10, so as to control whether the AC signal generator 34 transmits AC signals to the electrode sheet 10 electrically connected to the port Y1 of the adapter 20.

[0078] The following will refer to Figures 3 to 5The working principle of the tumor electric field treatment system 100 of this embodiment is described in detail.

[0079] Specifically, when it is necessary to detect the temperature of each electrode unit 12 of a certain electrode sheet 10, the electric field generator 30 controls the corresponding group of AC signal switches 35 to be completely disconnected, and the first controller 22 of the adapter 20 or the second controller 32 of the electric field generator 30 controls each of the multiple bidirectional switching switches 26 of a group of bidirectional switching switches 26 electrically connected to the electrode sheet 10 to perform the action of turning on the first end and disconnecting the second end in sequence and in time sharing. At the same time, the first controller 22 of the adapter 20 or the second controller 32 of the electric field generator 30 controls each of the grounding switches 25 of a group of grounding switches 25 electrically connected to the electrode sheet 10 to be turned on in sequence and in time sharing. At this time, the temperature detection signals of the temperature sensors 14 of one or more electrode units 12 in each row group of the electrode sheet 10 can be collected in time sharing and in sequence through multiple detection channels A, B, C, and D of a group of analog-to-digital converters 23 corresponding to the electrode sheet 10. Each detection channel A, B, C, and D of each group of analog-to-digital converters 23 only collects the temperature detection signals of the temperature sensors 14 of one or more corresponding electrode units 12 in each electrode unit 12 in the same group of the electrode sheet 10 at the same time. Among the five grounding switches 25 in a group of grounding switches 25 corresponding to the electrode sheet 10, only one grounding switch 25 can be turned on at the same time, and the other four grounding switches 25 are turned off.

[0080] Specifically, when all the AC signal switches 35 of the corresponding group are disconnected; the first grounding switch 25-1 is closed, and the remaining grounding switches 25 are disconnected; and the first end of the first bidirectional switching switch 26-1 is turned on and the second end is disconnected, and the first ends of the remaining bidirectional switching switches 26 are disconnected and the second ends are turned on, at this time, the temperature sensor 14 of the electrode unit 12-1 in the first row group is energized, and the first detection channel A in the group of analog-to-digital converters 23 samples to obtain the temperature detection signal of the temperature sensor 14 of the electrode unit 12-1 in the first row group. When all the AC signal switches 35 of the corresponding group are disconnected; the second grounding switch 25-2 is closed, and the remaining grounding switches 25 are disconnected; and the first end of the first bidirectional switching switch 26-1 is turned on and the second end is disconnected, and the first ends of the remaining bidirectional switching switches 26 are disconnected and the second ends are turned on, at this time, the two temperature sensors 14 of the electrode unit 12-1 to the electrode unit 12-2 in the first row group are energized, and the first detection channel A in the group of analog-to-digital converters 23 samples to obtain the temperature detection signal after the two temperature sensors 14 of the electrode unit 12-1 to the electrode unit 12-2 in the first row group are merged. When all the AC signal switches 35 of the corresponding group are disconnected; the third grounding switch 25-3 is closed, and the remaining grounding switches 25 are disconnected; and the first end of the first bidirectional switching switch 26-1 is turned on and the second end is disconnected, and the first ends of the remaining bidirectional switching switches 26 are all disconnected and the second ends are all turned on, at this time, the three temperature sensors 14 of the electrode unit 12-1 to the electrode unit 12-3 in the first row group are energized, and the first detection channel A in the group of analog-to-digital converters 23 samples to obtain the temperature detection signal after the three temperature sensors 14 of the electrode unit 12-1 to the electrode unit 12-3 in the first row group are merged. When all the AC signal switches 35 of the corresponding group are disconnected; the fourth grounding switch 25-4 is closed, and the remaining grounding switches 25 are disconnected; and the first end of the first bidirectional switching switch 26-1 is turned on and the second end is disconnected, and the first ends of the remaining bidirectional switching switches 26 are disconnected and the second ends are turned on, at this time, the four temperature sensors 14 of the electrode unit 12-1 to the electrode unit 12-4 in the first row group are energized, and the first detection channel A in the group of analog-to-digital converters 23 samples to obtain the temperature detection signal after the four temperature sensors 14 of the electrode unit 12-1 to the electrode unit 12-4 in the first row group are merged. When all the AC signal switches 35 of the corresponding group are disconnected; the fifth grounding switch 25-5 is closed, and the remaining grounding switches 25 are disconnected; and the first end of the first bidirectional switching switch 26-1 is turned on and the second end is disconnected, and the first ends of the remaining bidirectional switching switches 26 are all disconnected and the second ends are all turned on, at this time, the five temperature sensors 14 of the electrode unit 12-1 to the electrode unit 12-5 in the first row group are energized, and the first detection channel A in the group of analog-to-digital converters 23 samples to obtain the temperature detection signal after the five temperature sensors 14 of the electrode unit 12-1 to the electrode unit 12-5 in the first row group are merged.

[0081] When all the AC signal switches 35 of the corresponding group are disconnected; the first grounding switch 25-1 is closed, and the remaining grounding switches 25 are disconnected; and the first end of the second two-way switch 26-2 is turned on and the second end is turned off, and the first ends of the remaining two-way switches 26 are all turned off and the second ends are all turned on, at this time, the temperature sensor 14 of the electrode unit 12-6 in the second row group is powered on, and the first detection channel B in the group of analog-to-digital converters 23 samples to obtain the temperature detection signal of the temperature sensor 14 of the electrode unit 12-6 in the second row group. When all the AC signal switches 35 of the corresponding group are disconnected; the second grounding switch 25-2 is closed, and the remaining grounding switches 25 are all disconnected; and the first end of the second two-way switch 26-2 is turned on and the second end is turned off, and the first ends of the remaining two-way switch 26 are all turned off and the second ends are all turned on, at this time, the two temperature sensors 14 of the electrode unit 12-6 to the electrode unit 12-7 in the second row group are powered on, and the second detection channel B in the group of analog-to-digital converters 23 samples to obtain the temperature detection signal after the two temperature sensors 14 of the electrode unit 12-6 to the electrode unit 12-7 in the second row group are combined. When all the AC signal switches 35 of the corresponding group are disconnected; the third grounding switch 25-3 is closed, and the remaining grounding switches 25 are disconnected; and the first end of the second bidirectional switching switch 26-2 is turned on and the second end is turned off, and the first ends of the remaining bidirectional switching switches 26 are all turned off and the second ends are all turned on, at this time, the three temperature sensors 14 of the electrode unit 12-6 to the electrode unit 12-8 in the second row group are energized, and the second detection channel B in the group of analog-to-digital converters 23 samples to obtain the temperature detection signal after the three temperature sensors 14 of the electrode unit 12-6 to the electrode unit 12-8 in the second row group are merged. When all the AC signal switches 35 of the corresponding group are disconnected; the fourth grounding switch 25-4 is closed, and the remaining grounding switches 25 are disconnected; and the first end of the second bidirectional switching switch 26-2 is turned on and the second end is turned off, and the first ends of the remaining bidirectional switching switches 26 are all turned off and the second ends are all turned on, at this time, the four temperature sensors 14 of the electrode unit 12-6 to the electrode unit 12-9 in the second row group are energized, and the second detection channel B in the group of analog-to-digital converters 23 samples to obtain the temperature detection signal after the four temperature sensors 14 of the electrode unit 12-6 to the electrode unit 12-9 in the second row group are merged. When all the AC signal switches 35 of the corresponding group are disconnected; the fifth grounding switch 25-5 is closed, and the remaining grounding switches 25 are disconnected; and the first end of the second bidirectional switching switch 26-2 is turned on and the second end is turned off, and the first ends of the remaining bidirectional switching switches 26 are all turned off and the second ends are all turned on, at this time, the five temperature sensors 14 of the electrode unit 12-6 to the electrode unit 12-10 in the second row group are energized, and the second detection channel B in the group of analog-to-digital converters 23 samples to obtain the temperature detection signal after the five temperature sensors 14 of the electrode unit 12-6 to the electrode unit 12-10 in the second row group are merged.

[0082] The first communication unit 27 is controlled by the first controller 22. The first controller 22 calculates and converts the digital temperature signals of each temperature sensor 14 through the first communication unit 27 and transmits the digital temperature signals to the electric field generator 30 in series.

[0083] Preferably, the temperature sensor 14 is a thermistor. Figure 3 As shown, when the serial numbers 12-1 to 12-20 of the electrode units 12 are used as the temperature measurement point numbers, the resistance value of the thermistor corresponding to each temperature measurement point number can be represented by Rtn. For example, the resistance value of the thermistor corresponding to the temperature measurement point number 12-1 is Rt1, which is specifically the resistance value of the first thermistor in the first row group at the corresponding temperature, and the resistance value of the thermistor corresponding to the temperature measurement point number 12-2 is Rt2, which is specifically the resistance value of the second thermistor in the first row group at the corresponding temperature, and so on.

[0084] After the first controller 22 obtains the temperature detection signal corresponding to the temperature measurement point number, the temperature detection signal is the resistance value of one or more corresponding combinations of all temperature sensors 14 of the electrode sheet 10, and calculates the actual temperature of the thermistor corresponding to the temperature measurement point number by the following formula (1):

[0085]

[0086] Among them, Tn is the actual temperature of the thermistor corresponding to the temperature measuring point number n, x is the temperature detection signal corresponding to the temperature measuring point number n obtained by sampling, span is the maximum range of the analog-to-digital converter 23, for example, when the analog-to-digital converter 23 uses a 16-bit sampling chip, span is 65535, and R is the resistance value of the voltage divider resistor 24.

[0087] The resistance value of the thermistor corresponding to the temperature measurement point number can be calculated by the following formula (2):

[0088]

[0089] It can be understood that by transforming formula (2), when the resistance value of the thermistor corresponding to the temperature measurement point number is obtained, the temperature detection signal of the thermistor corresponding to the temperature measurement point number can be obtained:

[0090]

[0091] Wherein, y is the temperature detection signal of the thermistor corresponding to the temperature measurement point number.

[0092] It should be noted that by selecting a voltage divider resistor 24 with a suitable resistance value, the current flowing through the thermistor can be limited to avoid excessive current causing excessive temperature rise of the thermistor, thereby affecting the test accuracy, and in severe cases may even cause damage to the thermistor.

[0093] Thus, the first controller 22 of the adapter 20 or the second controller 32 of the electric field generator 30 can collect the temperature detection signals of the temperature sensors 14 of all the electrode units 12 of a certain electrode sheet 10 by controlling a group of two-way switching switches 26 and a group of grounding switches 25 that are electrically connected to the electrode sheet 10. Similarly, the temperature detection signals of the temperature sensors 14 of each electrode unit 12 of other electrode sheets 10 can be obtained. The first controller 22, multiple groups of analog-to-digital converters 23 and multiple groups of two-way switching switches 26 can automatically perform the above-mentioned temperature detection signal collection operation through pre-programmed program codes to obtain the temperature detection signals of all the temperature sensors 14 on the electrode sheet 10. Similarly, the temperature detection signals of all the temperature sensors 14 on at least one pair of electrode sheets 10 are obtained through this operation.

[0094] The tumor electric field therapy system 100 of the present application can realize real-time and comprehensive monitoring of the temperature of all electrode units 12 on the electrode sheet 10 without increasing the weight of the electrode sheet 10 or the core of the first cable 13 electrically connected to the electrode sheet 10, and then determine whether the electrode sheet 10 is qualified based on the obtained temperature detection signal; or determine whether the temperature sensor 14 of the electrode sheet 10 is faulty or abnormal based on the obtained temperature detection signal, and determine whether the electrode sheet 10 needs to be replaced based on the number of faulty or abnormal temperature sensors 14 obtained; or if the electrode sheet is qualified, identify the type of the electrode sheet based on the obtained temperature detection signal; or if the electrode sheet is qualified, determine whether the electrode unit 12 of the electrode sheet 10 is over-temperature based on the obtained temperature detection signal, and then control the alternating electric signal applied to the electrode sheet 10 or the electrode unit 12 of the corresponding column of the electrode sheet 10, so as to avoid low-temperature burns on the patient's body surface when the electrode sheet 10 is used for tumor treatment. In addition, the flexible circuit board 11 of the electrode sheet 10 of the present application is electrically connected to the dielectric element 15 of the same electrode unit 12 and the signal end 14-2 of the temperature sensor 14 through the same dual-purpose signal line 19. While it can transmit both AC signals and DC signals for temperature signal collection and collected temperature detection signals through the dual-purpose signal line 19, it also greatly reduces the number of conductive traces (grounding line 18, dual-purpose signal line 19) arranged thereon, reduces the wiring difficulty of the flexible circuit board 11, simplifies the manufacturing process, reduces the weight of the flexible circuit board 11, and reduces the manufacturing cost. The electrode sheet 10 of the present application can also switch between applying AC signals for tumor treatment and transmitting DC signals for temperature collection and transmitting collected temperature detection signals through the combined control of the grounding switch 25 electrically connected to the grounding line 18 arranged thereon and the bidirectional switching switch 26 electrically connected to the dual-purpose signal line 19.

[0095] When it is necessary to apply an alternating current signal to the patient through the electrode units 12 of a certain electrode sheet 10, the first controller 22 of the adapter 20 or the second controller 32 of the electric field generator 30 controls all the grounding switches 25 in a group of grounding switches 25 corresponding to the electrode sheet 10 to be disconnected, and at the same time controls all the bidirectional switching switches 26 in a group of bidirectional switching switches 26 corresponding to the electrode sheet 10 to be switched to their respective second ends, so that the first ends of the bidirectional switching switches 26 are all disconnected and the second ends are all turned on, so that all the dual-purpose signal lines 19 of the electrode sheet 10 are electrically connected to an AC signal line 28 corresponding to the adapter 20 and the electrode sheet 10, thereby transmitting the alternating current signal to the electrode units 12 of the electrode sheet 10.When the temperature detection signal of the temperature sensor 14 of all the electrode units 12 of the electrode sheet 10 is far lower than the preset temperature threshold stored in the electric field generator 30 or the adapter 20, the electric field generator 30 controls the AC signal generator 34 through its second controller 32 to continue to generate an AC signal with an increased voltage or current amplitude or a constant voltage or current amplitude, and then transmits it to the corresponding pair of electrode sheets 10 through a corresponding AC signal line 28 of the adapter 20, so that the pair of electrode sheets 10 continue to apply the AC signal; when the temperature detection signal of the temperature sensor 14 of all the electrode units 12 of the electrode sheet 10 is lower than but close to the preset temperature threshold stored in the electric field generator 30 or the adapter 20 The electric field generator 30 can reduce the voltage or current of the alternating current signal generated by the AC signal generator 34 through the second controller 32, thereby reducing the voltage or current of the alternating current signal applied to the pair of electrode sheets 10; when it is detected that the temperature detection signal of the temperature sensor 14 of an electrode unit 12 in a certain electrode sheet 10 is greater than a preset temperature threshold, the electric field generator 30 controls the AC signal switch 35 electrically connected to the electrode sheet 10 to be disconnected through the second controller 32 to stop applying the alternating current signal to the electrode sheet 10; or the second controller 32 of the electric field generator 30 or the first controller 22 of the adapter 20 controls all the bidirectional switches 26 electrically connected to the electrode sheet 10 The switching switches 26 are all switched from the second end to the first end, that is, the first ends of all the bidirectional switches of a group of bidirectional switching switches 26 electrically connected to the electrode sheet 10 are all turned on and the second ends are all turned off, thereby stopping the application of the alternating electric signal to the electrode sheet 10; or, when it is detected that the temperature detection signal of the temperature sensor 14 of an electrode unit 12 of a certain electrode sheet 10 is greater than the preset temperature threshold, the second controller 32 of the electric field generator 30 controls the AC signal switch 35 electrically connected to the electrode sheet 10 to continue to be turned on, and the second controller 32 of the electric field generator 30 or the first controller 22 of the adapter 20 controls a bidirectional switching switch electrically connected to the electrode unit 12 of the electrode sheet 10 to be turned on. The switch 26 is switched from its second end to its first end, and the second controller 32 of the electric field generator 30 or the first controller 22 of the adapter 20 simultaneously controls the remaining bidirectional switches 26 electrically connected to the electrode units 12 of the electrode sheet 10 whose temperature detection signals do not exceed the preset temperature threshold and are in different rows from the electrode units 12 whose temperature detection signals exceed the preset temperature threshold to continue to maintain electrical connection with their respective second ends, so as to stop applying the AC signal to all the electrode units 12 in the row where the electrode units 12 whose temperature detection signals of the electrode sheet 10 exceed the preset temperature threshold are located, and continue to apply the AC signal to the electrode units 12 in the remaining rows whose temperature detection signals of the electrode sheet 10 do not exceed the preset temperature threshold. In this way, the control method of applying the AC signal based on the temperature detection signal of the tumor electric field treatment system 100 is realized.

[0096] In the embodiment of the present application, the grounding switch 25 electrically connected to the multi-way grounding wires 18 of the electrode sheet 10 and the bidirectional switch 26 electrically connected to the multi-way dual-purpose signal wires 19 of the electrode sheet 10 are both provided in the adapter 20. However, in other embodiments, the grounding switch 25 electrically connected to the grounding wire 18 and the bidirectional switch 26 electrically connected to the dual-purpose signal wire 19 can also be provided on the electrode sheet 10 or provided in the electric field generator 30, which will not be described in detail here. In addition, the analog-to-digital converter 23 provided in the adapter 20 can also be provided in the electric field generator 30 and directly controlled by the second controller 32.

[0097] The present application also provides other embodiments of the electrode sheet 10 and the adapter 20. The differences among the multiple embodiments of the electrode sheet 10 are mainly the different numbers of electrode units 12 and / or the different circuit distribution methods of the electrode units 12. The multiple embodiments of the adapter 20 are adapted to the electrode sheets 10 in different embodiments. The main difference is the different numbers of grounding switches 25 and bidirectional switching switches 26, which will be explained separately below.

[0098] like Figure 6 As shown, the present application also provides another tumor treatment system 100A. The electrode sheet 10A in the tumor treatment system 100A includes 13 electrode units 12 and 13 temperature sensors 14 corresponding to the electrode units 12. The 13 electrode units 12 are arranged in an array of five rows and five columns in the spatial structure. The first and last rows are each provided with two electrode units, and the middle three rows are each provided with three electrode units. The first and last rows have a total of four electrode units 12 arranged in two columns, and the middle three rows have a total of nine electrode units 12 arranged in three columns, and are staggered with the two columns formed by the electrode units 12 in the first and last rows. The flexible circuit board 11A is provided with a plurality of connecting portions 111, and each electrode unit 12 is connected to all adjacent electrode units 12 through the connecting portions 111. In other structures of the electrode sheet 10A, some electrode units 12 may exist, especially the electrode units 12 located at the periphery may be spaced from the adjacent electrode units 12 without the connecting portions 111. As Figure 7 As shown, the electrode sheet 10A' and the electrode sheet 10A" form a gap D1 between the two electrode units 12 in the first row and the last row, and form a gap D2 between some of the electrode units 12 located in the middle three rows and the adjacent electrode units 12. The intervals D1 and D2 can avoid wrinkles when attaching the electrode sheets 10A' and 10A".

[0099] refer to Figure 8As shown, the flexible circuit board 11A of the electrode sheet 10A of the second embodiment arranges the 13 electrode units 12 into three rows and five columns in terms of circuit connection, wherein two rows each have five electrode units 12, and the remaining row has three electrode units 12. The electrode sheet 10A includes five grounding wires 18 and three dual-purpose signal wires 19, each of which is used to ground the grounding terminals 14-1 of the temperature sensors 14 in the same column group, and each dual-purpose signal wire 19 is respectively connected to all the electrode units 12 in each row group, for receiving temperature detection signals or transmitting AC signals.

[0100] The three dual-purpose signal lines 19 of the electrode sheet 10A include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, and a third dual-purpose signal line 19-3. In the three row groups of the electrode sheet 10A, the first row group includes electrode units 12-1 to 12-5, the second row group includes electrode units 12-6 to 12-10, and the third row group includes electrode units 12-11 to 12-13. One end of the first dual-purpose signal line 19-1 is connected in series with the dielectric elements 15 of the five electrode units 12 from electrode unit 12-1 to electrode unit 12-5 and the signal end 14-2 of the temperature sensor 14; one end of the second dual-purpose signal line 19-2 is connected in series with the dielectric elements 15 of the five electrode units 12 from electrode unit 12-6 to electrode unit 12-10 and the signal end 14-2 of the temperature sensor 14; one end of the third dual-purpose signal line 19-3 is connected in series with the dielectric elements 15 of the three electrode units 12 from electrode unit 12-11 to electrode unit 12-3 and the signal end 14-2 of the temperature sensor 14. In short, each dual-purpose signal line 19 connects the dielectric elements 15 of the electrode units 12 in the same row group and the signal end 14-2 of the corresponding temperature sensor 14 in series and is used to connect to the adapter 20A.

[0101] The five grounding wires 18 of the electrode sheet 10A are respectively a first grounding wire 18-1, a second grounding wire 18-2, a third grounding wire 18-3, a fourth grounding wire 18-4 and a fifth grounding wire 18-5. Specifically, the first grounding wire 18-1 is used to short-circuit the grounding terminals 14-1 of the temperature sensors 14 corresponding to the electrode units 12-1, 12-6 and 12-11 in the first column group and then to ground; the second grounding wire 18-2 is used to short-circuit the grounding terminals 14-1 of the temperature sensors 14 corresponding to the electrode units 12-2, 12-7 and 12-12 in the second column group and then to ground; the third grounding wire 18-3 is used to short-circuit the grounding terminals 14-1 of the temperature sensors 14 corresponding to the electrode units 12-2, 12-7 and 12-12 in the third column group and then to ground; -3, the grounding terminals 14-1 of the temperature sensors 14 corresponding to the electrode units 12-8 and 12-13 are short-circuited and grounded; the fourth grounding wire 18-4 is used to short-circuit the grounding terminals 14-1 of the temperature sensors 14 corresponding to the electrode units 12-4 and 12-9 in the fourth column group and ground them; the fifth grounding wire 18-5 is used to short-circuit the grounding terminals 14-1 of the temperature sensors 14 corresponding to the electrode units 12-5 and 12-10 in the fifth column group and ground them. In short, each grounding wire 18 short-circuits the grounding terminals 14-1 of the temperature sensors 14 of all the electrode units 12 in each column group and grounds them.

[0102] Combination Fig. 9 The electrode sheet 10A of the second embodiment is adapted to the adapter 20A of the second embodiment. The adapter 20A is provided with five grounding switches 25 (a first grounding switch 25-1, a second grounding switch 25-2, a third grounding switch 25-3, a third grounding switch 25-4, and a third grounding switch 25-5) and three bidirectional switching switches 26 (a first bidirectional switching switch 26-1, a second bidirectional switching switch 26-2, and a third bidirectional switching switch 26-3). The first grounding switch 25-1, the second grounding switch 25-2, the third grounding switch 25-3, the fourth grounding switch 25-4, and the fifth grounding switch 25-5 on the adapter 20A are electrically connected to the first grounding wire 18-1, the second grounding wire 18-2, the third grounding wire 18-3, the fourth grounding wire 18-4, and the fifth grounding wire 18-5 of the electrode sheet 10A through the first connector 40A. The first two-way switch 26-1, the second two-way switch 26-2 and the third two-way switch 26-3 on the adapter 20A are electrically connected to the first two-purpose signal line 19-1, the second two-purpose signal line 19-2 and the third two-purpose signal line 19-3 of the electrode sheet 10A through the first connector 40A.

[0103] The working mode of the tumor electric field treatment system formed by the electrode sheet 10A, the adapter 20A and the electric field generator 30 is the same as the previous tumor electric field treatment system 100. When the second ends of all the two-way switching switches 26 are turned on, all the dual-purpose signal lines 19 and the AC signal line 28 are turned on, and all the electrode units 12 are connected to the AC signal; in all the two-way switching switches 26, the first end of one two-way switching switch 26 is turned on and the second end is turned off, and the second ends of the remaining two-way switching switches 26 are turned on and the first ends are turned off in sequence and time-sharing. At the same time, the grounding switches 25 are turned on in sequence to obtain the temperature detection signals of the temperature sensors 14 of each electrode unit 12 of each row group in sequence.

[0104] refer to Fig.10 As shown, the electrode sheet 10B of the third embodiment is provided with 13 electrode units 12 like the electrode sheet 10A of the second embodiment, but the flexible circuit board 11B of the electrode sheet 10B arranges the 13 electrode units 12 into four rows and four columns in the circuit, wherein three rows are provided with four electrode units 12 each, and the remaining row is provided with one electrode unit 12. The electrode sheet 10B includes four grounding wires 18 and four dual-purpose signal wires 19, each of which is used to ground the grounding end 14-1 of the temperature sensor 14 of the same column group, and each dual-purpose signal wire 19 is respectively connected to all the electrode units 12 in each row group, and is used to receive temperature detection signals or transmit AC signals.

[0105] The four dual-purpose signal lines 19 of the electrode sheet 10B include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, a third dual-purpose signal line 19-3, and a fourth dual-purpose signal line 19-4. In the four row groups of the electrode sheet 10B, the first row group includes electrode units 12-1 to 12-4, the second row group includes electrode units 12-5 to 12-8, the third row group includes electrode units 12-9 to 12-12, and the third row group includes electrode unit 12-13. One end of the first dual-purpose signal line 19-1 is connected in series with the dielectric elements 15 of the four electrode units 12 from electrode unit 12-1 to electrode unit 12-4 and the signal end 14-2 of the temperature sensor 14; one end of the second dual-purpose signal line 19-2 is connected in series with the dielectric elements 15 of the four electrode units 12 from electrode unit 12-5 to electrode unit 12-8 and the signal end 14-2 of the temperature sensor 14; one end of the third dual-purpose signal line 19-3 is connected in series with the dielectric elements 15 of the four electrode units 12 from electrode unit 12-9 to electrode unit 12-12 and the signal end 14-2 of the temperature sensor 14; one end of the fourth dual-purpose signal line 19-4 is connected in series with the dielectric element 15 of electrode unit 12-13 and the signal end 14-2 of the temperature sensor 14. In short, each dual-purpose signal line 19 connects the dielectric elements 15 of the electrode units 12 in the same row group and the signal end 14-2 of the corresponding temperature sensor 14 in series and is used to connect to the adapter 20B.

[0106] The four grounding wires 18 of the electrode sheet 10B are respectively a first grounding wire 18 - 1 , a second grounding wire 18 - 2 , a third grounding wire 18 - 3 and a fourth grounding wire 18 - 4 . Specifically, the first grounding wire 18-1 is used to short-circuit the grounding ends 14-1 of the temperature sensors 14 corresponding to the electrode units 12-1, 12-5, 12-9 and 12-13 in the first column group and ground them; the second grounding wire 18-2 is used to short-circuit the grounding ends 14-1 of the temperature sensors 14 corresponding to the electrode units 12-2, 12-6 and 12-10 in the second column group and ground them; the third grounding wire 18-3 is used to short-circuit the grounding ends 14-1 of the temperature sensors 14 corresponding to the electrode units 12-3, 12-7 and 12-11 in the third column group and ground them; the fourth grounding wire 18-4 is used to short-circuit the grounding ends 14-1 of the temperature sensors 14 corresponding to the electrode units 12-4, 12-8 and 12-12 in the fourth column group and ground them. In short, each ground line 18 short-circuits the ground terminals 14 - 1 of the temperature sensors 14 of all the electrode units 12 in each column group and connects them to ground.

[0107] Combination Fig.12The adapter 20B of the third embodiment can be adapted to the electrode sheet 10B of the third embodiment. The first grounding switch 25-1, the second grounding switch 25-2, the third grounding switch 25-3 and the fourth grounding switch 25-4 on the adapter 20B are electrically connected to the first grounding line 18-1, the second grounding line 18-2, the third grounding line 18-3 and the fourth grounding line 18-4 of the electrode sheet 10B through the second connector 40B. The first two-way switch 26-1, the second two-way switch 26-2, the third two-way switch 26-3 and the fourth two-way switch 26-4 on the adapter 20B are electrically connected to the first two-purpose signal line 19-1, the second two-purpose signal line 19-2, the third two-purpose signal line 19-3 and the fourth two-purpose signal line 19-4 of the electrode sheet 10B through the first connector 40B.

[0108] The working mode of the tumor electric field treatment system formed by the electrode sheet 10B, the adapter 20B and the electric field generator 30 is the same as the previous tumor electric field treatment system 100. When the second ends of all the two-way switching switches 26 are turned on, all the dual-purpose signal lines 19 and the AC signal line 28 are turned on, and all the electrode units 12 are connected to the AC signal; in all the two-way switching switches 26, the first end of one two-way switching switch 26 is turned on and the second end is turned off, and the second ends of the remaining two-way switching switches 26 are turned on and the first ends are turned off in sequence and time-sharing. At the same time, the grounding switches 25 are turned on in sequence to obtain the temperature detection signals of the temperature sensors 14 of each electrode unit 12 of each row group in sequence.

[0109] refer to Fig.11 As shown, the electrode sheet 10C of the fourth embodiment is provided with 13 electrode units 12 like the electrode sheet 10B of the third embodiment. The flexible circuit board 11C of the electrode sheet 10C arranges the 13 electrode units 12 into four rows and four columns on the circuit, wherein three rows are provided with three electrode units 12 each, and the remaining row is provided with four electrode units 12. The electrode sheet 10C includes four grounding wires 18 and four dual-purpose signal wires 19, each of which is used to ground the grounding end 14-1 of the temperature sensor 14 of the same column group, and each dual-purpose signal wire 19 is respectively connected to all the electrode units 12 in each row group, and is used to receive temperature detection signals or transmit AC signals.

[0110] The four dual-purpose signal lines 19 of the electrode sheet 10C include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, a third dual-purpose signal line 19-3, and a fourth dual-purpose signal line 19-4. In the four row groups of the electrode sheet 10B, the first row group includes electrode units 12-1 to 12-4, the second row group includes electrode units 12-5 to 12-7, the third row group includes electrode units 12-8 to 12-10, and the fourth row group includes electrode units 12-11 to 12-13. One end of the first dual-purpose signal line 19-1 is connected in series with the dielectric elements 15 of the four electrode units 12 from electrode unit 12-1 to electrode unit 12-4 and the signal ends 14-2 of the temperature sensors 14; one end of the second dual-purpose signal line 19-2 is connected in series with the dielectric elements 15 of the three electrode units 12 from electrode unit 12-5 to electrode unit 12-7 and the signal ends 14-2 of the temperature sensors 14; one end of the third dual-purpose signal line 19-3 is connected in series with the dielectric elements 15 of the three electrode units 12 from electrode unit 12-8 to electrode unit 12-10 and the signal ends 14-2 of the temperature sensors 14; one end of the fourth dual-purpose signal line 19-4 is connected in series with the dielectric elements 15 of the three electrode units 12 from electrode unit 12-11 to electrode unit 12-13 and the signal ends 14-2 of the temperature sensors 14. In short, each dual-purpose signal line 19 short-circuits each dielectric element 15 of each electrode unit 12 in the same row group and the signal terminal 14 - 2 of the corresponding temperature sensor 14 , and then connects them in series and is used to connect to the adapter 20B.

[0111] The four grounding lines 18 of the electrode sheet 10C are respectively a first grounding line 18 - 1 , a second grounding line 18 - 2 , a third grounding line 18 - 3 and a fourth grounding line 18 - 4 . Specifically, the first grounding wire 18-1 is used to short-circuit the grounding terminals 14-1 of the temperature sensors 14 corresponding to the electrode units 12-1, 12-5, 12-8 and 12-12 in the first column group and ground them; the second grounding wire 18-2 is used to short-circuit the grounding terminals 14-1 of the temperature sensors 14 corresponding to the electrode units 12-2, 12-6, 12-9 and 12-12 in the second column group and ground them; the third grounding wire 18-3 is used to short-circuit the grounding terminals 14-1 of the temperature sensors 14 corresponding to the electrode units 12-3, 12-7, 12-10 and 12-13 in the third column group and ground them; the fourth grounding wire 18-4 is used to ground the grounding terminal 14-1 of the temperature sensor 14 of the electrode unit 12-4 in the fourth column group. In short, each ground line 18 short-circuits the ground terminals 14 - 1 of the temperature sensors 14 of all the electrode units 12 in each column group and connects them to ground.

[0112] Combination Fig.12 The adapter 20B of the third embodiment can be adapted to the electrode sheet 10C of the fourth embodiment. The first grounding switch 25-1, the second grounding switch 25-2, the third grounding switch 25-3 and the fourth grounding switch 25-4 on the adapter 20B are respectively electrically connected to the first grounding line 18-1, the second grounding line 18-2, the third grounding line 18-3 and the fourth grounding line 18-4 of the electrode sheet 10C through the second connector 40B. The first two-way switch 26-1, the second two-way switch 26-2, the third two-way switch 26-3 and the fourth two-way switch 26-4 on the adapter 20B are respectively electrically connected to the first two-purpose signal line 19-1, the second two-purpose signal line 19-2, the third two-purpose signal line 19-3 and the fourth two-purpose signal line 19-4 of the electrode sheet 10C through the first connector 40B.

[0113] The working mode of the tumor electric field therapy system formed by the electrode sheet 10C, the adapter 20B and the electric field generator 30 is the same as the previous tumor electric field therapy system 100. When the second ends of all the two-way switching switches 26 are turned on, all the dual-purpose signal lines 19 and the AC signal line 28 are turned on, and all the electrode units 12 are connected to the AC signal; in all the two-way switching switches 26, the first end of one two-way switching switch 26 is turned on and the second end is turned off, and the second ends of the remaining two-way switching switches 26 are turned on and the first ends are turned off in sequence and time-sharing. At the same time, the grounding switches 25 are turned on in sequence to obtain the temperature detection signals of the temperature sensors 14 of each electrode unit 12 of each row group in sequence.

[0114] refer to Fig.13 and Fig.14 As shown, the present application also provides another tumor treatment system 100D, the electrode sheet 10D of the fifth embodiment is provided with 9 electrode units 12, and the flexible circuit board 11D of the electrode sheet 10D arranges the 9 electrode units 12 into three rows and four columns on the circuit, wherein two rows are provided with 4 electrode units 12 each, and the other row is provided with 1 electrode unit 12. The electrode sheet 10D includes 4 grounding wires 18 and 3 dual-purpose signal wires 19, each of which is used to ground the grounding end 14-1 of the temperature sensor 14 of the same column group, and each dual-purpose signal wire 19 is respectively connected to all the electrode units 12 in each row group, and is used to receive temperature detection signals or transmit AC signals.

[0115] The three dual-purpose signal lines 19 of the electrode sheet 10D include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, and a third dual-purpose signal line 19-3. Among the three row groups of the electrode sheet 10D, the first row group includes electrode units 12-1 to 12-4, the second row group includes electrode units 12-5 to 12-8, and the third row group includes electrode unit 12-9. One end of the first dual-purpose signal line 19-1 is connected in series with the dielectric elements 15 of the four electrode units 12 of electrode units 12-1 to 12-4 and the signal ends 14-2 of the temperature sensors 14 of the four electrode units; one end of the second dual-purpose signal line 19-2 is connected in series with the dielectric elements 15 of the four electrode units 12 of electrode units 12-5 to 12-8 and the signal ends 14-2 of the temperature sensors 14 of the four electrode units; one end of the third dual-purpose signal line 19-3 is connected with the dielectric element 15 of the electrode unit 12-9 and the signal ends 14-2 of the temperature sensors 14 of the four electrode units 12-1 to 12-4. In short, each dual-purpose signal line 19 short-circuits each dielectric element 15 of each electrode unit 12 in the same row group and the signal terminal 14 - 2 of the corresponding temperature sensor 14 , and then connects them in series and is used to connect to the adapter 20D.

[0116] The four grounding wires 18 of the electrode sheet 10D are respectively a first grounding wire 18-1, a second grounding wire 18-2, a third grounding wire 18-3 and a fourth grounding wire 18-4. Specifically, the first grounding wire 18-1 is used to short-circuit the grounding terminals 14-1 of the temperature sensors 14 corresponding to the electrode units 12-1, 12-5 and 12-9 in the first column group and then to ground; the second grounding wire 18-2 is used to short-circuit the grounding terminals 14-1 of the temperature sensors 14 corresponding to the electrode units 12-2 and 12-6 in the second column group and then to ground; the third grounding wire 18-3 is used to short-circuit the grounding terminals 14-1 of the temperature sensors 14 corresponding to the electrode units 12-3 and 12-7 in the third column group and then to ground; the fourth grounding wire 18-4 is used to short-circuit the grounding terminals 14-1 of the temperature sensors 14 corresponding to the electrode units 12-4 and 12-8 in the fourth column group and then to ground. In short, each ground line 18 short-circuits the ground terminals 14 - 1 of the temperature sensors 14 of all the electrode units 12 in each column group and connects them to the ground.

[0117] Combination Fig.15The adapter 20D of the fourth embodiment can be adapted to the electrode sheet 10D of the fifth embodiment. The first grounding switch 25-1, the second grounding switch 25-2, the third grounding switch 25-3 and the fourth grounding switch 25-4 on the adapter 20D are respectively electrically connected to the first grounding line 18-1, the second grounding line 18-2, the third grounding line 18-3 and the fourth grounding line 18-4 of the electrode sheet 10D through the second connector 40D. The first two-way switch 26-1, the second two-way switch 26-2 and the third two-way switch 26-3 on the adapter 20C are respectively electrically connected to the first dual-purpose signal line 19-1, the second dual-purpose signal line 19-2 and the third dual-purpose signal line 19-3 of the electrode sheet 10D through the first connector 40D.

[0118] The working mode of the tumor electric field therapy system formed by the electrode sheet 10D, the adapter 20D and the electric field generator 30 is the same as that of the previous tumor electric field therapy system 100. When the second ends of all the two-way switching switches 26 are turned on, all the dual-purpose signal lines 19 and the AC signal line 28 are turned on, and all the electrode units 12 are connected to the AC signal; in all the two-way switching switches 26, the first end of one two-way switching switch 26 is turned on and the second end is turned off, and the second ends of the remaining two-way switching switches 26 are turned on and the first ends are turned off in sequence and time-sharing. At the same time, the grounding switches 25 are turned on in sequence to obtain the temperature detection signals of the temperature sensors 14 of each electrode unit 12 of each row group in sequence.

[0119] refer to Fig.16 As shown, the electrode sheet 10E of the sixth embodiment is also provided with 9 electrode units 12. The flexible circuit board 11E of the electrode sheet 10E arranges the 9 electrode units 12 into three rows and three columns on the circuit, and each row is provided with 3 electrode units 12. The electrode sheet 10E includes 3 grounding wires 18 and 3 dual-purpose signal wires 19. Each grounding wire 18 is used to ground the grounding end 14-1 of the temperature sensor 14 in the same row group, and each dual-purpose signal wire 19 is respectively connected to all electrode units 12 in each row group for receiving temperature detection signals or transmitting AC signals.

[0120] The three dual-purpose signal lines 19 of the electrode sheet 10E include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, and a third dual-purpose signal line 19-3. In the three row groups of the electrode sheet 10E, the first row group includes electrode units 12-1 to 12-3, the second row group includes electrode units 12-4 to 12-6, and the third row group includes electrode units 12-7 to 12-9. One end of the first dual-purpose signal line 19-1 is connected in series with the dielectric elements 15 of the three electrode units 12 from electrode unit 12-1 to electrode unit 12-3 and the signal end 14-2 of the temperature sensor 14; one end of the second dual-purpose signal line 19-2 is connected in series with the dielectric elements 15 of the three electrode units 12 from electrode unit 12-4 to electrode unit 12-6 and the signal end 14-2 of the temperature sensor 14; one end of the third dual-purpose signal line 19-3 is connected in series with the dielectric elements 15 of electrode unit 12-7 to electrode unit 12-9 and the signal end 14-2 of the temperature sensor 14. In short, each dual-purpose signal line 19 connects the dielectric elements 15 of the electrode units 12 in the same row group and the signal end 14-2 of the corresponding temperature sensor 14 in series and is used to connect to the adapter 20E.

[0121] The three grounding wires 18 of the electrode sheet 10E are respectively the first grounding wire 18-1, the second grounding wire 18-2 and the third grounding wire 18-3. Specifically, the first grounding wire 18-1 is used to short-circuit the grounding terminals 14-1 of the temperature sensors 14 corresponding to the electrode units 12-1, 12-4 and 12-7 in the first column group and then to ground; the second grounding wire 18-2 is used to short-circuit the grounding terminals 14-1 of the temperature sensors 14 corresponding to the electrode units 12-2, 12-5 and 12-8 in the second column group and then to ground; the third grounding wire 18-3 is used to short-circuit the grounding terminals 14-1 of the temperature sensors 14 corresponding to the electrode units 12-3, 12-6 and 12-9 in the third column group and then to ground. In short, each grounding wire 18 short-circuits the grounding terminals 14-1 of the temperature sensors 14 of all the electrode units 12 in each column group and grounds them.

[0122] Combination Fig.17The adapter 20E of the fifth embodiment can be adapted to the electrode sheet 10E of the sixth embodiment. The first grounding switch 25-1, the second grounding switch 25-2 and the third grounding switch 25-3 on the adapter 20E are electrically connected to the first grounding line 18-1, the second grounding line 18-2 and the third grounding line 18-3 of the electrode sheet 10E through the second connector 40E. The first two-way switch 26-1, the second two-way switch 26-2 and the third two-way switch 26-3 on the adapter 20E are electrically connected to the first dual-purpose signal line 19-1, the second dual-purpose signal line 19-2 and the third dual-purpose signal line 19-3 of the electrode sheet 10E through the first connector 40D.

[0123] The working mode of the tumor electric field treatment system formed by the electrode sheet 10E, the adapter 20E and the electric field generator 30 is the same as the previous tumor electric field treatment system 100. When the second ends of all the two-way switching switches 26 are turned on, all the dual-purpose signal lines 19 and the AC signal line 28 are turned on, and all the electrode units 12 are connected to the AC signal; in all the two-way switching switches 26, the first end of one two-way switching switch 26 is turned on and the second end is turned off, and the second ends of the remaining two-way switching switches 26 are turned on and the first ends are turned off in sequence and time-sharing. At the same time, the grounding switches 25 are turned on in sequence to obtain the temperature detection signals of the temperature sensors 14 of each electrode unit 12 of each row group in sequence.

[0124] In the tumor electric field therapy system of the present application, the flexible circuit board of each electrode sheet divides its electrode unit 12 into multiple rows and columns in the circuit, and electrically connects the electrode unit 12 in the same column to the same ground line 18, and electrically connects the electrode unit 12 in the same row to the same dual-purpose signal line 19; the adapter 20 is provided with multiple grounding switches 25 and multiple bidirectional switching switches 26, each grounding line 18 of the electrode sheet is electrically connected to the corresponding grounding switch 25 one by one, and each dual-purpose signal line 19 is electrically connected to the corresponding bidirectional switching switch 26 one by one. Among them, the number of grounding switches 25 is equal to the number of grounding lines 18, and the number of bidirectional switching switches 26 is equal to the number of dual-purpose signal lines 19. Selecting a suitable adapter for the corresponding electrode sheet avoids the occurrence of idle grounding switches 25 and / or bidirectional switching switches 26, which facilitates circuit control.

[0125] The present application also provides some temperature detection methods and AC signal application control methods, which are described below using the electrode sheet 10 as an example.

[0126] The present application embodiment provides an electrode sheet temperature detection method, which is applied to the above-mentioned electrode sheet 10 or tumor electric field treatment system 100. Fig.18 As shown, it includes the following steps:

[0127] Step 210: Control the electric field generator 30 to disconnect the AC signal applied to the dielectric element 15 of each electrode unit 12 of the electrode sheet 10, and control each bidirectional switch 26 electrically connected to each electrode unit 12 of the electrode sheet 10 to sequentially connect the DC signal applied to the signal terminal 14-2 of the temperature sensor 14 of each electrode unit 12 in each row group of the electrode sheet 10 in a time-sharing manner;

[0128] Step 220 : sequentially turn on the grounding switches 25 electrically connected to the grounding terminals 14 - 1 of the temperature sensors 14 of the electrode units 12 of the electrode sheet 10 to obtain temperature detection signals from the temperature sensors 14 of the electrode units 12 of the electrode sheet 10 .

[0129] Step 210 is specifically as follows: controlling the AC signal switch 35 of the electric field generator 30 to disconnect the AC signal applied to the dielectric element 15 of each electrode unit 12 of the electrode sheet 10, and controlling each of the two-way switching switches 26 electrically connected to each electrode unit 12 of the electrode sheet 10 to switch from the end thereof electrically connected to the AC signal (i.e., the second end of the two-way switching switch 26) to the end thereof electrically connected to the DC signal (i.e., the first end of the two-way switching switch 26) in a time-sharing sequence, and the remaining two-way switching switches 26 switch from the end thereof electrically connected to the DC signal to the end thereof electrically connected to the AC signal.

[0130] The electrode sheet temperature detection method of the present application can quickly and accurately obtain the temperatures of all electrode units of the electrode sheet; and based on the temperature detection signals of all the temperature sensors of the electrode sheet, it can be judged whether the temperature sensors of the electrode sheet are faulty, whether there is an abnormality, whether the electrode sheet is qualified, and whether it needs to be replaced; it is also possible to judge whether each electrode unit of the electrode sheet is over-temperature based on the temperature detection signals of all the temperature sensors of the electrode sheet when each temperature sensor of the electrode sheet is normal, and then control the alternating current signal applied to the electrode sheet or to each electrode unit of the electrode sheet; it is also possible to identify the type of electrode sheet when there is no abnormality in the temperature detection signals of each temperature sensor of the electrode sheet.

[0131] Ginseng Fig.19 As shown, the embodiment of the present application also provides a method for controlling application of an alternating current signal for electric field therapy of tumors, which includes the above steps 210 and 220, and after step 220, further includes:

[0132] Step 260 : When it is determined that the electrode sheet does not need to be replaced, the alternating current signal applied to each electrode unit 12 of the electrode sheet 10 is controlled or adjusted according to the temperature detection signal of the temperature sensor 14 of each electrode unit 12 of the electrode sheet 10 .

[0133] Controlling or adjusting the alternating current signal applied to each electrode unit 12 of the electrode sheet 10 in step 260 also includes:

[0134] Step 261: When the temperature detection signals of the electrode units 12 of the electrode sheet 10 obtained do not exceed the preset temperature threshold, continue to apply an alternating current signal to the electrode units 12 of the electrode sheet 10; or

[0135] Step 262 : when there is a temperature detection signal exceeding a preset temperature threshold among the temperature detection signals of all the electrode units 12 of the electrode sheet 10 , stop applying the alternating current signal to the electrode units 12 of the electrode sheet 10 .

[0136] Stopping the application of the AC signal to the electrode unit 12 of the electrode sheet 10 described in step 262 includes stopping applying the AC signal to all electrode units 12 of the electrode sheet 10, stopping applying the AC signal to the electrode unit 12 in the electrode sheet 10 whose temperature detection signal exceeds the preset temperature threshold, and stopping applying the AC signal to all electrode units 12 in the row where the electrode unit 12 in the electrode sheet 10 whose temperature detection signal exceeds the preset temperature threshold is located.

[0137] When the application of the AC signal to the electrode unit 12 in the electrode sheet 10 whose temperature detection signal exceeds the preset temperature threshold is stopped, the AC signal continues to be applied to the electrode unit 12 in the electrode sheet 10 whose temperature detection signal does not exceed the preset temperature threshold.

[0138] When the application of the AC signal to all the electrode units 12 in the row where the electrode unit 12 whose temperature detection signal exceeds the preset temperature threshold in the electrode sheet 10 is located is stopped, the AC signal continues to be applied to all the electrode units 12 in the electrode sheet 10 where the temperature detection signal does not exceed the preset temperature threshold and which are in different rows from the electrode unit 12 whose temperature detection signal exceeds the preset temperature threshold.

[0139] The process of continuing to apply the alternating current signal to the electrode sheet 10 in step 261 is specifically as follows:

[0140] Step 263: When the temperature detection signal is much lower than the preset temperature threshold, the AC signal is continuously applied to each electrode unit 12 of the electrode sheet 10 in a manner of increasing the voltage or current amplitude of the AC signal applied to each electrode unit 12 of the electrode sheet 10 or the AC signal is continuously applied to each electrode unit 12 of the electrode sheet 10 in a manner of keeping the voltage or current amplitude of the AC signal applied to each electrode unit 12 of the electrode sheet 10 unchanged; or

[0141] Step 264: When the temperature detection signal approaches a preset temperature threshold, continue to apply the AC signal to each electrode unit 12 of the electrode sheet 10 in a manner that keeps the voltage or current amplitude of the AC signal applied to each electrode unit 12 of the electrode sheet 10 unchanged, or continue to apply the AC signal to each electrode unit 12 of the electrode sheet 10 in a manner that reduces the voltage or current amplitude of the AC signal applied to each electrode unit 12 of the electrode sheet 10.

[0142] Ginseng Fig. 20 As shown, the present application also provides a signal control method for tumor electric field therapy, which is used for the above-mentioned electrode sheet 10, and the method includes:

[0143] Step 310: Combining and controlling the grounding switch 25 and the bidirectional switch 26 electrically connected to the corresponding electrode sheet 10 to apply an AC signal to each electrode unit 12 of the electrode sheet 10 and executing step 320;

[0144] Step 320: Combining and controlling the grounding switch 25 and the bidirectional switch 26 electrically connected to the electrode sheet 10 to collect the temperature detection signals of the electrode units of the electrode sheet 10 in a row and executing step 330;

[0145] Step 330: Determine the combined control mode of the grounding switch 25 and the bidirectional switch 26 electrically connected to the electrode sheet 10 according to the collected temperature detection signal and execute step 340;

[0146] Step 340 : Control the working state of each electrode unit 12 of the electrode sheet 10 according to the determined combined control mode of the grounding switch 25 and the bidirectional switch 26 .

[0147] The working state of each electrode unit 12 of the electrode sheet 10 described in step 340 includes at least one of: stopping applying the AC signal and continuing to collect the temperature detection signal and stopping collecting the temperature detection signal and continuing to apply the AC signal. Continuing to apply the AC signal includes continuing to apply the AC signal in a manner of increasing the voltage or current amplitude of the currently applied AC signal, continuing to apply the AC signal in a manner of keeping the voltage or current amplitude of the currently applied AC signal unchanged, and continuing to apply the AC signal in a manner of reducing the voltage or current amplitude of the currently applied AC signal.

[0148] The working state of each electrode unit 12 of the electrode sheet 10 is determined by the temperature detection signal collected by the electrode unit 12. Each electrode unit 12 of the electrode sheet 10 is divided into different areas, and each electrode unit 12 in each area can be cyclically switched between applying an AC signal and collecting a temperature detection signal through the combination control of a grounding switch 25 and a bidirectional switch 26.

[0149] The present application also provides another method for applying an alternating current signal for tumor electric field therapy, which is applied to the above-mentioned tumor electric field therapy system 100. Please refer to Fig.21 As shown, the AC signal application method includes:

[0150] Step 610: determining the area of ​​the electrode unit 12 in the electrode sheet 10 where the alternating current signal needs to be applied;

[0151] Step 611: Combining and controlling a plurality of grounding switches 25 and a plurality of bidirectional switching switches 26 electrically connected to the electrode sheet 10 to apply an alternating current signal.

[0152] In step 611, “combining and controlling a plurality of grounding switches 25 and a plurality of bidirectional switching switches 26 electrically connected to the electrode sheet 10” is specifically as follows:

[0153] Step 612: disconnect all grounding switches 25 electrically connected to the electrode sheet 10;

[0154] Step 613: determining the row group where the electrode units 12 to which the AC signal needs to be applied are located according to the area where the electrode units 12 to which the AC signal needs to be applied are located;

[0155] Step 614: determining the bidirectional switches 26 electrically connected to the electrode units 12 in the row groups according to the row groups where the electrode units 12 to which the AC signals need to be applied are located;

[0156] In step 610 , every four adjacent electrode units 12 in the electrode sheet 10 are divided into a region, and the four electrode units 12 in each region correspond to a row group and are connected to a dual-purpose signal line 19 corresponding to the same bidirectional switch 26 .

[0157] Step 615: Control the bidirectional switching switch 26 electrically connected to the electrode unit 12 to which an AC signal needs to be applied so that the electrode unit 12 to which an AC signal needs to be applied is electrically connected to the AC signal line 28 to apply the AC signal; at the same time, control the remaining bidirectional switching switches 26 so that the electrical connection between each electrode unit 12 in the area where no AC signal needs to be applied and the AC signal line 28 is disconnected to stop applying the AC signal.

[0158] In step 615, "the electrode units to which an AC signal needs to be applied are electrically connected to the AC signal line 28 to apply the AC signal and the electrical connection between the electrode units 12 in the area where the AC signal does not need to be applied and the AC signal line 28 is disconnected to stop applying the AC signal" is achieved by placing the bidirectional switching switch 26 electrically connected to the electrode units 12 in the row group corresponding to the area to which the AC signal is to be applied in the electrode sheet 10 at its second end, and placing all the bidirectional switching switches 26 electrically connected to the electrode units 12 in the remaining row groups at their first ends.

[0159] The first controller 22 or the electric field generator 30 in the adapter 20 of the tumor electric field therapy system 100 of the embodiment of the present application is provided with a preset quantity threshold, a first preset temperature t1, a second preset temperature t2 and a preset temperature threshold t0, wherein the first preset temperature t1 is lower than the second preset temperature t2, and the second preset temperature t2 is lower than the preset temperature threshold t0.

[0160] The present application also provides an AC signal application method based on a temperature detection signal, which is used in the above-mentioned tumor electric field treatment system 100. Fig. 22 As shown, the application method includes:

[0161] Step 710: Start the tumor therapeutic field system 100;

[0162] Step 711: Combining and controlling the grounding switch 25 and the bidirectional switch 26 electrically connected to the corresponding electrode sheet 10 to apply an AC signal to each electrode unit 12 of the electrode sheet 10;

[0163] Step 712: Combining and controlling the grounding switch 25 and the bidirectional switch 26 electrically connected to the electrode sheet 10 to obtain the temperature of each electrode unit 12 of the electrode sheet 10;

[0164] Step 713: Determine whether there is an electrode unit 12 whose temperature exceeds the first preset temperature t1, and execute step 714 when there is no electrode unit 12 whose temperature exceeds the first preset temperature t1; and execute step 715 when there is an electrode unit 12 whose temperature exceeds the first preset temperature t1;

[0165] Step 714: Continue to apply the AC signal to each electrode unit 12 of the electrode sheet 10 in a manner of increasing the voltage or current amplitude of the currently applied AC signal and return to step 712;

[0166] Step 715: Determine whether there is an electrode unit 12 whose temperature exceeds the second preset temperature t2; when there is no electrode unit 12 whose temperature exceeds the second preset temperature t2, execute step 716; when there is an electrode unit 12 whose temperature exceeds the second preset temperature t2, execute step 717;

[0167] Step 716: Continue to apply the AC signal to each electrode unit 12 of the electrode sheet 10 in a manner that keeps the voltage or current amplitude of the currently applied AC signal unchanged and return to step 712;

[0168] Step 717: Determine whether there is an electrode unit 12 whose temperature exceeds the preset temperature threshold t0. If there is no electrode unit 12 whose temperature exceeds the preset temperature threshold t0, execute step 718; if there is an electrode unit whose temperature exceeds the preset temperature threshold t0, execute step 719;

[0169] Step 718: Continue to apply the AC signal to all electrode units 12 of the electrode sheet 10 in a manner of reducing the voltage or current amplitude of the currently applied AC signal and return to step 712;

[0170] Step 719: Determine the number of over-temperature regions and execute step 720, wherein the over-temperature region is a region containing electrode units whose temperature exceeds a preset temperature threshold t0, and the non-over-temperature region is a region in which the temperature of all electrode units does not exceed the preset temperature threshold t0;

[0171] Step 720: Determine whether the number of over-temperature areas exceeds a preset number threshold, and execute step 721 when the number of over-temperature areas exceeds the preset number threshold; and execute step 724 when the number of over-temperature areas does not exceed the preset number threshold.

[0172] Step 721: stop applying the AC signal to each electrode unit 12 of the electrode sheet 10 and execute step 722;

[0173] Step 722: Combining and controlling the grounding switch 25 and the bidirectional switch 26 electrically connected to the electrode sheet 10 to obtain the temperature of each electrode unit 12 of the electrode sheet 10 and executing step 723;

[0174] Step 723: Determine whether there is an electrode unit 12 with a temperature exceeding the first preset temperature t1, and when the electrode sheet 10 does not have an electrode unit 12 with a temperature exceeding the first preset temperature t1, return to step 711; when the electrode sheet 10 has an electrode unit 12 with a temperature exceeding the first preset temperature t1, return to step 722;

[0175] Step 724: distinguishing an over-temperature area from a non-over-temperature area according to whether there is an electrode unit 12 whose temperature exceeds a preset temperature threshold t0, and executing step 725 when the area is an over-temperature area, and executing step 726 when the area is a non-over-temperature area;

[0176] Step 725: stop applying the AC signal to each electrode unit 12 in the over-temperature area and execute step 731;

[0177] Step 726: Determine whether the temperature of each electrode unit 12 in the non-over-temperature area does not exceed the first preset temperature t1. When the temperature of each electrode unit 12 in the non-over-temperature area does not exceed the first preset temperature t1, execute step 727. When the temperature of each electrode unit 12 in the non-over-temperature area exceeds the first preset temperature t1, execute step 728.

[0178] Step 727: Continue to apply the AC signal to each electrode unit 12 in the non-overtemperature area of ​​the electrode sheet 10 in a manner of increasing the voltage or current amplitude of the currently applied AC signal and execute step 731;

[0179] Step 728: Determine whether the temperature of each electrode unit 12 in the non-overtemperature area does not exceed the second preset temperature t2. When the temperature of each electrode unit 12 in the non-overtemperature area does not exceed the second preset temperature t2, execute step 729. When the temperature of each electrode unit 12 in the non-overtemperature area exceeds the second preset temperature t2, execute step 730.

[0180] Step 729: Continue to apply the AC signal to each electrode unit 12 in the non-overtemperature area of ​​the electrode sheet 10 in a manner that the voltage or current amplitude of the currently applied AC signal remains unchanged and execute step 731;

[0181] Step 730: Continue to apply the AC signal to each electrode unit 12 in the non-overtemperature area of ​​the electrode sheet 10 in a manner of reducing the voltage or current amplitude of the currently applied AC signal and execute step 731;

[0182] Step 731: Combining and controlling the grounding switch 25 and the bidirectional switch 26 electrically connected to the electrode sheet 10 to reacquire the temperature of each electrode unit 12 of the electrode sheet 10 and selecting to execute step 732 or step 734, wherein the temperature of each electrode unit 12 of the electrode sheet 10 includes the temperature of each electrode unit 12 in the over-temperature area and the temperature of each electrode unit 12 in the non-over-temperature area;

[0183] Step 732: Determine whether the temperature of each electrode unit 12 in the over-temperature area does not exceed the first preset temperature t1, and execute step 733 when the temperature of each electrode unit 12 in the over-temperature area does not exceed the first preset temperature t1. When the temperature of each electrode unit 12 in the over-temperature area exceeds the first preset temperature t1, return to step 731;

[0184] Step 733: re-determine the area as a non-overtemperature area and execute step 734;

[0185] Step 734: Determine whether the temperatures of the electrode units 12 in the non-over-temperature area do not exceed the first preset temperature t1. When the temperatures of the electrode units 12 in the non-over-temperature area do not exceed the first preset temperature t1, execute step 735. When the temperatures of the electrode units 12 in the non-over-temperature area exceed the first preset temperature t1, execute step 736.

[0186] Step 735: Continue to apply the AC signal to each electrode unit 12 in the non-overtemperature area by increasing the voltage or current amplitude of the currently applied AC signal and return to step 712;

[0187] Step 736: Determine whether the temperatures of the electrode units 12 in the non-over-temperature area do not exceed the second preset temperature t2. When the temperatures of the electrode units 12 in the non-over-temperature area do not exceed the second preset temperature t2, execute step 737. When the temperatures of the electrode units 12 in the non-over-temperature area exceed the second preset temperature t2, execute step 738.

[0188] Step 737: Continue to apply the AC signal to each electrode unit 12 in the non-overtemperature area in a manner that the voltage or current amplitude of the currently applied AC signal remains unchanged and return to step 712;

[0189] Step 738: Determine whether the temperatures of the electrode units 12 in the non-over-temperature area do not exceed the preset temperature threshold t0. When the temperatures of the electrode units 12 in the non-over-temperature area do not exceed the preset temperature threshold t0, execute step 739. When the temperatures of the electrode units 12 in the non-over-temperature area exceed the preset temperature threshold t0, return to step 719.

[0190] Step 739 : Continue to apply the AC signal to each electrode unit 12 in the non-overtemperature area in a manner of reducing the voltage or current amplitude of the currently applied AC signal and return to step 712 .

[0191] Among them, Fig. 22 As shown, the process of combining and controlling the ground switch 25 and the bidirectional switch 26 electrically connected to the corresponding electrode sheet 10 in step 711 to apply an AC signal to each electrode unit 12 of the electrode sheet is specifically as follows:

[0192] Disconnect all grounding switches 25 electrically connected to the corresponding electrode sheets 10, and simultaneously switch all bidirectional switches 26 electrically connected to the corresponding electrode sheets 10 to one end that applies an AC signal to each electrode unit 12; or

[0193] Disconnect all grounding switches 25 electrically connected to the corresponding electrode sheet 10, and simultaneously switch all bidirectional switches 26 electrically connected to the corresponding electrode sheet 10 to one end that electrically connects each electrode unit 12 to the AC signal line 28; or

[0194] All the grounding switches 25 electrically connected to the corresponding electrode sheets 10 are disconnected, and at the same time, all the bidirectional switches 26 electrically connected to the corresponding electrode sheets 10 are switched to their respective second ends.

[0195] The process of obtaining the temperature of each electrode unit 12 of the electrode sheet 10 in step 712, step 722, and step 731 is specifically as follows:

[0196] Control the AC signal switch 35 of the electric field generator 30 to disconnect the alternating electric signal applied to each electrode unit 12 of the electrode sheet 10, control each of the two-way switching switches 26 electrically connected to the electrode sheet 10 to switch from the end at which the alternating electric signal is applied to each electrode unit 12 to the end at which the temperature of each electrode unit 12 is collected in sequence in a time-sharing manner, and control the remaining two-way switching switches 26 to switch from the end at which the temperature of each electrode unit 12 is collected to the end at which the alternating electric signal is applied to each electrode unit 12, and close the control switches 54 electrically connected to the electrode units 12 of the electrode sheet 10 in sequence in a time-sharing manner to obtain the temperature of each electrode unit 12 of the electrode sheet 10; or

[0197] Controlling the AC signal switch 35 of the electric field generator 30 to disconnect the alternating electric signal applied to each electrode unit 12 of the electrode sheet 10, controlling each of the two-way switching switches 26 electrically connected to the electrode sheet 10 to switch from the second end thereof, which applies the alternating electric signal to each electrode unit 12, to the first end thereof in time-division order, and controlling the remaining two-way switching switches 26 to switch from the first end thereof to the second end thereof, which applies the alternating electric signal to each electrode unit 12, and closing the control switches 54 electrically connected to the electrode units 12 of the electrode sheet 10 in time-division order to obtain the temperature of each electrode unit 12 of the electrode sheet 10; or

[0198] Controlling the AC signal switch 35 of the electric field generator 30 to disconnect the alternating electric signal applied to each electrode unit 12 of the electrode sheet 10, controlling each of the two-way switching switches 26 electrically connected to the electrode sheet 10 to switch the electrode sheet 10 from being electrically connected to the AC signal line 28 to being electrically connected to the corresponding analog-to-digital converter 23, and the remaining two-way switching switches 26 to being electrically connected to the AC signal line 28 from being electrically connected to the corresponding analog-to-digital converter 23, and closing the control switches 54 electrically connected to the electrode units 12 of the electrode sheet 10 in a time-division order to obtain the temperature of each electrode unit 12 of the electrode sheet 10; or

[0199] The AC signal switch 35 of the electric field generator 30 is controlled to disconnect the alternating electric signal applied to each electrode unit 12 of the electrode sheet 10, and each of the two-way switching switches 26 electrically connected to the electrode sheet 10 is controlled to switch each electrode unit 12 of the electrode sheet 10 from transmitting an alternating electric signal to transmitting a direct electric signal or a temperature detection signal in a time-division order, and the remaining two-way switching switches 26 switch from transmitting a direct electric signal or a temperature detection signal to transmitting an alternating electric signal, and the control switch 54 electrically connected to each electrode unit 12 of the electrode sheet 10 is closed in a time-division order to obtain the temperature of each electrode unit 12 of the electrode sheet 10. The first preset temperature in steps 713, 723, 726, 732, and 734 is 40°C-40.3°C, preferably 40.2°C. The second preset temperature in step 715, step 728 and step 736 is 40.4°C to 40.6°C, preferably 40.5°C; the preset temperature threshold in step 717 and step 738 is 41°C to 41.5°C, preferably 41°C; the preset quantity threshold in step 720 is preferably 2.

[0200] The process of continuing to apply the AC signal in step 714, step 716, step 718, step 727, step 729, step 730, step 735, step 737, and step 739 is specifically as follows:

[0201] Disconnect the grounding switch 25 electrically connected to the electrode unit 12 to which the AC signal continues to be applied, and at the same time control the bidirectional switch 26 electrically connected to the electrode unit 12 to which the AC signal continues to be applied to conduct the AC signal transmission path electrically connected to the electrode unit 12 to which the AC signal continues to be applied, so as to continue to apply the AC signal to the electrode unit 12 to which the AC signal continues to be applied; or

[0202] Disconnect the grounding switch 25 electrically connected to the electrode unit 12 to which the AC signal is to be continuously applied, and at the same time control the bidirectional switch 26 electrically connected to the electrode unit 12 to which the AC signal is to be continuously applied to switch from its respective first end to its respective second end so as to continue to apply the AC signal to the electrode unit 12 to which the AC signal is to be continuously applied; or

[0203] Disconnect the grounding switch 25 electrically connected to the electrode unit 12 to which the AC signal needs to be continuously applied, and at the same time control the second ends of the bidirectional switching switches 26 electrically connected to the electrode unit 12 to which the AC signal needs to be continuously applied to be electrically connected to the AC signal line 28 so as to continue to apply the AC signal to the electrode unit 12 to which the AC signal needs to be continuously applied; or

[0204] Disconnect the grounding switch 25 electrically connected to the electrode unit 12 to which the AC signal needs to be continuously applied, and at the same time control the bidirectional switch 26 electrically connected to the electrode unit 12 to which the AC signal needs to be continuously applied to close the second end and disconnect the first end thereof, so as to continue to apply the AC signal to the electrode unit 12 to which the AC signal needs to be continuously applied; or

[0205] Disconnect the grounding switch 25 electrically connected to the electrode unit 12 to which the AC signal needs to continue to be applied, and at the same time control the bidirectional switching switch 26 electrically connected to the electrode unit 12 to which the AC signal needs to continue to be applied so that the electrode unit 12 to which the AC signal needs to continue to be applied switches from transmitting the temperature detection signal to applying the AC signal.

[0206] Increasing the voltage or current amplitude of the currently applied AC power signal in step 714, step 727, and step 735 is specifically to boost the voltage of the currently applied AC power signal in a manner of a DC voltage amplitude increment of 0.03 V per second.

[0207] Continuing to apply the AC signal in a manner of reducing the voltage or current amplitude of the currently applied AC signal in step 718, step 730, and step 739 specifically means continuing to apply the AC signal in a manner of 5V less than the voltage amplitude of the currently applied AC signal and continuing for 3 minutes.

[0208] The process of stopping applying the alternating current signal to each electrode unit 12 of the electrode sheet 10 in step 721 is specifically as follows:

[0209] Control the bidirectional switch 26 electrically connected to the electrode sheet 10 to disconnect the electrical connection between each electrode unit 12 of the electrode sheet 10 and the AC signal line 28; or

[0210] Control the bidirectional switch 26 electrically connected to the electrode sheet 10 to switch all ends from the end where the alternating current signal is applied to each electrode unit 12 to the end where the temperature of each electrode unit 12 is collected; or

[0211] Control the bidirectional switch 26 electrically connected to the electrode sheet 10 to switch all the second ends of the electrode units 12 applying the AC signal to the first ends; or

[0212] Controlling the bidirectional switch 26 electrically connected to the electrode sheet 10 to switch the electrode sheet 10 from electrically connecting each electrode unit 12 with the AC signal line 28 to electrically connecting each electrode unit 12 with the corresponding analog-to-digital converter 23; or

[0213] The bidirectional switch 26 electrically connected to the electrode sheet 10 is controlled to switch each electrode unit 12 of the electrode sheet 10 from transmitting an AC signal to transmitting a DC signal or a temperature detection signal.

[0214] The process of stopping applying the AC signal to each electrode unit 12 in the over-temperature area in step 725 is specifically as follows:

[0215] Control the bidirectional switch 26 electrically connected to each electrode unit 12 in the over-temperature area to disconnect the electrical connection between each electrode unit 12 in the over-temperature area and the AC signal line 28; or

[0216] Control the bidirectional switch 26 electrically connected to each electrode unit 12 in the over-temperature region to switch all ends thereof from one end thereof applying an AC signal to each electrode unit 12 in the over-temperature region to one end thereof enabling each electrode unit 12 in the over-temperature region to collect temperature; or

[0217] Control the bidirectional switch 26 electrically connected to each electrode unit 12 in the over-temperature region to switch all of the second ends thereof, which apply the alternating current signal to each electrode unit 12 in the over-temperature region, to the first end thereof; or

[0218] Control the bidirectional switch 26 electrically connected to each electrode unit 12 in the over-temperature region to switch each electrode unit 12 in the over-temperature region from being electrically connected to the AC signal line 28 to being electrically connected to the corresponding analog-to-digital converter 23; or

[0219] The bidirectional switch 26 electrically connected to each electrode unit 12 in the over-temperature area is controlled to switch each electrode unit 12 in the over-temperature area from transmitting an AC signal to transmitting a DC signal or a temperature detection signal.

[0220] In the above application method, the tumor electric field treatment system 100 includes at least two pairs of electrode sheets 10 to alternately apply alternating electric fields with different directions, and each electrode sheet 10 can alternately switch between applying an alternating current signal and transmitting a temperature detection signal.

[0221] The first controller 22 or the electric field generator 30 in the adapter 20 of the tumor electric field treatment system 100 of the present embodiment of the present application is also provided with a third preset temperature t3, and the third preset temperature t3 is higher than the second preset temperature t2 but still lower than the preset temperature threshold t0. The third preset temperature t3 is closer to the preset temperature threshold t0 than the second preset temperature t2. The present embodiment of the present application also provides an AC signal control method based on a temperature detection signal, which is used in the above tumor electric field treatment system, Fig.23 As shown, the AC signal control method includes:

[0222] Step 810: Start the tumor therapeutic field system 100;

[0223] Step 811: Combining and controlling the grounding switch 25 and the bidirectional switch 26 electrically connected to the corresponding electrode sheet 10 to apply an AC signal to each electrode unit 12 of the electrode sheet 10;

[0224] Step 812: Combining and controlling the grounding switch 25 and the bidirectional switch 26 electrically connected to the electrode sheet 10 to obtain the temperature of each electrode unit 12 of the electrode sheet 10;

[0225] Step 813: Determine whether there is an electrode unit 12 whose temperature exceeds the first preset temperature t1, and execute step 814 when there is no electrode unit 12 whose temperature exceeds the first preset temperature t1; and execute step 815 when there is an electrode unit 12 whose temperature exceeds the first preset temperature t1;

[0226] Step 814: Continue to apply the AC signal to each electrode unit 12 of the electrode sheet 10 in a manner of increasing the voltage or current amplitude of the currently applied AC signal and return to step 812;

[0227] Step 815: Determine whether there is an electrode unit 12 whose temperature exceeds the second preset temperature t2; when there is no electrode unit 12 whose temperature exceeds the second preset temperature t2, execute step 816; when there is an electrode unit 12 whose temperature exceeds the second preset temperature t2, execute step 817;

[0228] Step 816: Continue to apply the AC signal to each electrode unit 12 of the electrode sheet 10 in a manner that the voltage or current amplitude of the currently applied AC signal remains unchanged and return to step 812;

[0229] Step 817: Determine whether there is an electrode unit 12 whose temperature exceeds the third preset temperature t3. If there is no electrode unit 12 whose temperature exceeds the third preset temperature t3, execute step 818; if there is an electrode unit whose temperature exceeds the third preset temperature t3, execute step 819;

[0230] Step 818: Continue to apply the AC signal to all electrode units 12 of the electrode sheet 10 in a manner of reducing the voltage or current amplitude of the currently applied AC signal and return to step 812;

[0231] Step 819: Determine whether there is an electrode unit 12 whose temperature exceeds the preset temperature threshold t0, and execute step 820 when there is no electrode unit 12 whose temperature exceeds the preset temperature threshold t0; execute step 821 when there is an electrode unit whose temperature exceeds the preset temperature threshold t0;

[0232] Step 820: Continue to apply the AC signal to all electrode units 12 of the electrode sheet 10 in a manner of reducing the voltage or current amplitude of the currently applied AC signal and return to step 812;

[0233] Step 821: Determine the number of over-temperature regions and execute step 822, wherein the over-temperature region is a region containing electrode units whose temperature exceeds a preset temperature threshold t0, and the non-over-temperature region is a region in which the temperature of all electrode units does not exceed the preset temperature threshold t0;

[0234] Step 822: Determine whether the number of over-temperature areas exceeds a preset number threshold, and execute step 823 when the number of over-temperature areas exceeds the preset number threshold; and execute step 826 when the number of over-temperature areas does not exceed the preset number threshold;

[0235] Step 823: stop applying the AC signal to each electrode unit 12 of the electrode sheet 10 and execute step 824;

[0236] Step 824: Combine and control the ground switch 25 and the bidirectional switch 26 electrically connected to the electrode sheet 10 to obtain the temperature of each electrode unit 12 of the electrode sheet 10 and execute step 825;

[0237] Step 825: Determine whether there is an electrode unit 12 with a temperature exceeding the first preset temperature t1. When the electrode sheet 10 does not have an electrode unit 12 with a temperature exceeding the first preset temperature t1, return to step 811. When the electrode sheet 10 has an electrode unit 12 with a temperature exceeding the first preset temperature t1, return to step 824.

[0238] Step 826: Distinguish the over-temperature area and the non-over-temperature area according to whether there is an electrode unit 12 whose temperature exceeds the preset temperature threshold t0, and execute step 827 when the area is the over-temperature area, and execute step 828 when the area is the non-over-temperature area;

[0239] Step 827: stop applying the AC signal to each electrode unit 12 in the over-temperature area and execute step 835;

[0240] Step 828: Determine whether the temperature of each electrode unit 12 in the non-overtemperature area does not exceed the first preset temperature t1. When the temperature of each electrode unit 12 in the non-overtemperature area does not exceed the first preset temperature t1, execute step 829. When the temperature of each electrode unit 12 in the non-overtemperature area exceeds the first preset temperature t1, execute step 830.

[0241] Step 829: Continue to apply the AC signal to each electrode unit 12 in the non-overtemperature area of ​​the electrode sheet 10 in a manner of increasing the voltage or current amplitude of the currently applied AC signal and execute step 835;

[0242] Step 830: Determine whether the temperature of each electrode unit 12 in the non-overtemperature area does not exceed the second preset temperature t2. When the temperature of each electrode unit 12 in the non-overtemperature area does not exceed the second preset temperature t2, execute step 831. When the temperature of each electrode unit 12 in the non-overtemperature area exceeds the second preset temperature t2, execute step 832.

[0243] Step 831: Continue to apply the AC signal to each electrode unit 12 in the non-overtemperature area of ​​the electrode sheet 10 in a manner that the voltage or current amplitude of the currently applied AC signal remains unchanged and execute step 835;

[0244] Step 832: Determine whether there is an electrode unit 12 in the non-overtemperature area whose temperature exceeds the third preset temperature t3, and execute step 833 when the temperature of each electrode unit 12 in the non-overtemperature area does not exceed the third preset temperature t3; and execute step 834 when there is a temperature exceeding the third preset temperature t3 among the temperatures of each electrode unit 12 in the non-overtemperature area;

[0245] Step 833: Continue to apply the AC signal to each electrode unit 12 in the non-overtemperature area of ​​the electrode sheet 10 in a manner of reducing the voltage or current amplitude of the currently applied AC signal and execute step 835;

[0246] Step 834: Continue to apply the AC signal to each electrode unit 12 in the non-overtemperature area of ​​the electrode sheet 10 in a manner of further reducing the voltage or current amplitude of the currently applied AC signal and execute step 835;

[0247] Step 835: Combining and controlling the grounding switch 25 and the bidirectional switch 26 electrically connected to the electrode sheet 10 to reacquire the temperature of each electrode unit 12 of the electrode sheet 10 and selecting to execute step 836 or step 838, wherein the temperature of each electrode unit 12 of the electrode sheet 10 includes the temperature of each electrode unit 12 in the over-temperature area and the temperature of each electrode unit 12 in the non-over-temperature area;

[0248] Step 836: Determine whether the temperature of each electrode unit 12 in the over-temperature area does not exceed the first preset temperature t1. When the temperature of each electrode unit 12 in the over-temperature area does not exceed the first preset temperature t1, execute step 837. When the temperature of each electrode unit 12 in the over-temperature area exceeds the first preset temperature t1, return to step 835.

[0249] Step 837: re-determine the area as a non-overtemperature area and execute step 838;

[0250] Step 838: Determine whether the temperatures of the electrode units 12 in the non-over-temperature area do not exceed the first preset temperature t1. When the temperatures of the electrode units 12 in the non-over-temperature area do not exceed the first preset temperature t1, execute step 839. When the temperatures of the electrode units 12 in the non-over-temperature area exceed the first preset temperature t1, execute step 840.

[0251] Step 839: Continue to apply the AC signal to each electrode unit 12 in the non-overtemperature area by increasing the voltage or current amplitude of the currently applied AC signal and return to step 812;

[0252] Step 840: Determine whether the temperatures of the electrode units 12 in the non-over-temperature area do not exceed the second preset temperature t2. When the temperatures of the electrode units 12 in the non-over-temperature area do not exceed the second preset temperature t2, execute step 841. When the temperatures of the electrode units 12 in the non-over-temperature area exceed the second preset temperature t2, execute step 842.

[0253] Step 841: Continue to apply the AC signal to each electrode unit 12 in the non-overtemperature area in a manner that the voltage or current amplitude of the currently applied AC signal remains unchanged and return to step 812;

[0254] Step 842: Determine whether the temperatures of the electrode units 12 in the non-over-temperature area do not exceed the third preset temperature t3. When the temperatures of the electrode units 12 in the non-over-temperature area do not exceed the third preset temperature t3, execute step 843. When the temperatures of the electrode units 12 in the non-over-temperature area exceed the third preset temperature t3, execute step 844.

[0255] Step 843: Continue to apply the AC signal to each electrode unit 12 in the non-overtemperature area in a manner of reducing the voltage or current amplitude of the currently applied AC signal and return to step 812;

[0256] Step 844: Determine whether the temperatures of the electrode units 12 in the non-over-temperature area do not exceed the preset temperature threshold t0. When the temperatures of the electrode units 12 in the non-over-temperature area do not exceed the preset temperature threshold t0, execute step 845. When the temperatures of the electrode units 12 in the non-over-temperature area exceed the preset temperature threshold t0, return to step 821.

[0257] Step 845 : Continue to apply the AC signal to each electrode unit 12 in the non-overtemperature area in a manner of further reducing the voltage or current amplitude of the currently applied AC signal and return to step 812 .

[0258] The process of combining and controlling the grounding switch 25 and the bidirectional switch 26 electrically connected to the corresponding electrode sheet 10 in step 811 to apply an AC signal to each electrode unit 12 of the electrode sheet is specifically as follows:

[0259] Disconnect all grounding switches 25 electrically connected to the corresponding electrode sheets 10, and simultaneously switch all bidirectional switches 26 electrically connected to the corresponding electrode sheets 10 to one end that applies an AC signal to each electrode unit 12; or

[0260] Disconnect all grounding switches 25 electrically connected to the corresponding electrode sheet 10, and simultaneously switch all bidirectional switches 26 electrically connected to the corresponding electrode sheet 10 to one end that electrically connects each electrode unit 12 to the AC signal line 28; or

[0261] All the grounding switches 25 electrically connected to the corresponding electrode sheets 10 are disconnected, and at the same time, all the bidirectional switches 26 electrically connected to the corresponding electrode sheets 10 are switched to their respective second ends.

[0262] The process of obtaining the temperature of each electrode unit 12 of the electrode sheet 10 in step 812, step 824, and step 835 is specifically as follows:

[0263] Control the AC signal switch 35 of the electric field generator 30 to disconnect the alternating electric signal applied to each electrode unit 12 of the electrode sheet 10, control each of the two-way switching switches 26 electrically connected to the electrode sheet 10 to switch from the end at which the alternating electric signal is applied to each electrode unit 12 to the end at which the temperature of each electrode unit 12 is collected in sequence in a time-sharing manner, and control the remaining two-way switching switches 26 to switch from the end at which the temperature of each electrode unit 12 is collected to the end at which the alternating electric signal is applied to each electrode unit 12, and close the control switches 54 electrically connected to the electrode units 12 of the electrode sheet 10 in sequence in a time-sharing manner to obtain the temperature of each electrode unit 12 of the electrode sheet 10; or

[0264] Controlling the AC signal switch 35 of the electric field generator 30 to disconnect the alternating electric signal applied to each electrode unit 12 of the electrode sheet 10, controlling each of the two-way switching switches 26 electrically connected to the electrode sheet 10 to switch from the second end thereof, which applies the alternating electric signal to each electrode unit 12, to the first end thereof in time-division order, and controlling the remaining two-way switching switches 26 to switch from the first end thereof to the second end thereof, which applies the alternating electric signal to each electrode unit 12, and closing the control switches 54 electrically connected to the electrode units 12 of the electrode sheet 10 in time-division order to obtain the temperature of each electrode unit 12 of the electrode sheet 10; or

[0265] Controlling the AC signal switch 35 of the electric field generator 30 to disconnect the alternating electric signal applied to each electrode unit 12 of the electrode sheet 10, controlling each of the two-way switching switches 26 electrically connected to the electrode sheet 10 to switch the electrode sheet 10 from being electrically connected to the AC signal line 28 to being electrically connected to the corresponding analog-to-digital converter 23, and the remaining two-way switching switches 26 to being electrically connected to the AC signal line 28 from being electrically connected to the corresponding analog-to-digital converter 23, and closing the control switches 54 electrically connected to the electrode units 12 of the electrode sheet 10 in a time-division order to obtain the temperature of each electrode unit 12 of the electrode sheet 10; or

[0266] The AC signal switch 35 of the electric field generator 30 is controlled to disconnect the alternating electric signal applied to each electrode unit 12 of the electrode sheet 10, and each of the two-way switching switches 26 electrically connected to the electrode sheet 10 is controlled to switch each electrode unit 12 of the electrode sheet 10 from transmitting an alternating electric signal to transmitting a direct electric signal or a temperature detection signal in a time-division order, and the remaining two-way switching switches 26 switch from transmitting a direct electric signal or a temperature detection signal to transmitting an alternating electric signal, and the control switch 54 electrically connected to each electrode unit 12 of the electrode sheet 10 is closed in a time-division order to obtain the temperature of each electrode unit 12 of the electrode sheet 10. The first preset temperature in steps 813, 825, 828, 836, and 838 is 40°C-40.3°C, preferably 40.2°C. The second preset temperature in step 815, step 830 and step 840 is 40.4°C to 40.6°C, preferably 40.5°C; the third preset temperature in step 817, step 832 and step 842 is 40.7°C to 40.9°C, preferably 40.8°C; the preset temperature threshold in step 819 and step 844 is 41°C to 41.5°C, preferably 41°C; the preset quantity threshold in step 822 is preferably 2.

[0267] The process of continuing to apply the AC signal in step 814, step 816, step 818, step 820, step 829, step 831, step 833, step 834, step 839, step 841, step 843, and step 845 is specifically as follows:

[0268] Disconnect the grounding switch 25 electrically connected to the electrode unit 12 to which the AC signal continues to be applied, and at the same time control the bidirectional switch 26 electrically connected to the electrode unit 12 to which the AC signal continues to be applied to conduct the AC signal transmission path electrically connected to the electrode unit 12 to which the AC signal continues to be applied, so as to continue to apply the AC signal to the electrode unit 12 to which the AC signal continues to be applied; or

[0269] Disconnect the grounding switch 25 electrically connected to the electrode unit 12 to which the AC signal is to be continuously applied, and at the same time control the bidirectional switch 26 electrically connected to the electrode unit 12 to which the AC signal is to be continuously applied to switch from its respective first end to its respective second end so as to continue to apply the AC signal to the electrode unit 12 to which the AC signal is to be continuously applied; or

[0270] Disconnect the grounding switch 25 electrically connected to the electrode unit 12 to which the AC signal needs to be continuously applied, and at the same time control the second ends of the bidirectional switching switches 26 electrically connected to the electrode unit 12 to which the AC signal needs to be continuously applied to be electrically connected to the AC signal line 28 so as to continue to apply the AC signal to the electrode unit 12 to which the AC signal needs to be continuously applied; or

[0271] Disconnect the grounding switch 25 electrically connected to the electrode unit 12 to which the AC signal needs to be continuously applied, and at the same time control the bidirectional switch 26 electrically connected to the electrode unit 12 to which the AC signal needs to be continuously applied to close the second end and disconnect the first end thereof, so as to continue to apply the AC signal to the electrode unit 12 to which the AC signal needs to be continuously applied; or

[0272] Disconnect the grounding switch 25 electrically connected to the electrode unit 12 to which the AC signal needs to continue to be applied, and at the same time control the bidirectional switching switch 26 electrically connected to the electrode unit 12 to which the AC signal needs to continue to be applied so that the electrode unit 12 to which the AC signal needs to continue to be applied switches from transmitting the temperature detection signal to applying the AC signal.

[0273] The method of increasing the voltage or current amplitude of the currently applied AC signal in step 814, step 829, and step 839 is to continue to apply the AC signal by boosting the currently applied AC signal with a DC voltage amplitude increment of 0.03V per second and then continue to apply the AC signal.

[0274] Continuing to apply the AC signal in a manner of reducing the voltage or current amplitude of the currently applied AC signal as described in step 818, step 820, step 833, step 834, step 843 and step 845 specifically means continuing to apply the AC signal in a manner of 5V less than the voltage amplitude of the currently applied AC signal and continuing for 3 minutes.

[0275] The process of stopping applying the AC signal to each electrode unit 12 of the electrode sheet 10 in step 823 is specifically as follows:

[0276] Control the bidirectional switch 26 electrically connected to the electrode sheet 10 to disconnect the electrical connection between each electrode unit 12 of the electrode sheet 10 and the AC signal line 28; or

[0277] Control the bidirectional switch 26 electrically connected to the electrode sheet 10 to switch all ends from the end where the alternating current signal is applied to each electrode unit 12 to the end where the temperature of each electrode unit 12 is collected; or

[0278] Control the bidirectional switch 26 electrically connected to the electrode sheet 10 to switch all the second ends of the electrode units 12 applying the AC signal to the first ends; or

[0279] Controlling the bidirectional switch 26 electrically connected to the electrode sheet 10 to switch the electrode sheet 10 from electrically connecting each electrode unit 12 with the AC signal line 28 to electrically connecting each electrode unit 12 with the corresponding analog-to-digital converter 23; or

[0280] The bidirectional switch 26 electrically connected to the electrode sheet 10 is controlled to switch each electrode unit 12 of the electrode sheet 10 from transmitting an AC signal to transmitting a DC signal or a temperature detection signal.

[0281] The process of stopping applying the AC signal to each electrode unit 12 in the over-temperature area in step 827 is specifically as follows:

[0282] Control the bidirectional switch 26 electrically connected to each electrode unit 12 in the over-temperature area to disconnect the electrical connection between each electrode unit 12 in the over-temperature area and the AC signal line 28; or

[0283] Control the bidirectional switch 26 electrically connected to each electrode unit 12 in the over-temperature region to switch all ends thereof from one end thereof applying an AC signal to each electrode unit 12 in the over-temperature region to one end thereof enabling each electrode unit 12 in the over-temperature region to collect temperature; or

[0284] Control the bidirectional switch 26 electrically connected to each electrode unit 12 in the over-temperature region to switch all of the second ends thereof, which apply the alternating current signal to each electrode unit 12 in the over-temperature region, to the first end thereof; or

[0285] Control the bidirectional switch 26 electrically connected to each electrode unit 12 in the over-temperature region to switch each electrode unit 12 in the over-temperature region from being electrically connected to the AC signal line 28 to being electrically connected to the corresponding analog-to-digital converter 23; or

[0286] The bidirectional switch 26 electrically connected to each electrode unit 12 in the over-temperature area is controlled to switch each electrode unit 12 in the over-temperature area from transmitting an AC signal to transmitting a DC signal or a temperature detection signal.

[0287] When the tumor electric field therapy system 100 is in a standby state before starting work, no AC signal is applied to the electrode unit 12. The first controller 22 of the adapter 20 or the second controller 32 of the electric field generator 30 controls the switching and switching timing of each bidirectional switching switch 26 and each grounding switch 25, so that the analog-to-digital converter 23 receives the temperature detection signal of the temperature sensor 14 corresponding to each row of electrode units 12 in turn.

[0288] The first controller 22 receives the temperature detection signal of the temperature sensor 14 corresponding to each electrode unit 12 through the analog-to-digital converter 23, and transmits it to the AC signal generator 34 of the electric field generator 30 through the first communication unit 27 and the second communication unit 33, and then controls or adjusts the alternating current signal applied to each electrode unit 12 through the second controller 32.

[0289] Although various operations are depicted in the drawings as being in a particular order, this should not be understood as requiring that the operations must be performed in the particular order shown or in sequential order, nor should it be understood as requiring that all illustrated operations must be performed to achieve desirable results.

[0290] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present application, rather than to limit them; although the present application has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein by equivalents; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the present application, and they should all be included in the scope of the claims and specification of the present application. In particular, as long as there is no structural conflict, the various technical features mentioned in the various embodiments can be combined in any way. The present application is not limited to the specific embodiments disclosed herein, but includes all technical solutions that fall within the scope of the claims.

Claims

1. An electrode sheet for electric field therapy of tumors, characterized in that: include: A plurality of electrode units, wherein the plurality of electrode units are divided into a plurality of row groups and a plurality of column groups on a circuit, wherein the electrode units include a dielectric element and a temperature sensor having a signal terminal and a ground terminal, and the dielectric element is short-circuited with the signal terminal of the temperature sensor; as well as A flexible circuit board, a plurality of electrode units are arranged at intervals on the flexible circuit board, the flexible circuit board is embedded with multiple conductive traces, the multiple conductive traces include multiple grounding wires and multiple dual-purpose signal wires, the grounding wires are arranged in a one-to-one correspondence with each column group, the grounding wires are short-circuited with the grounding ends of the temperature sensors corresponding to each electrode unit of each column group and then grounded, the dual-purpose signal wires are arranged in a one-to-one correspondence with each row group, and the dual-purpose signal wires are connected in series with each electrode unit of the corresponding row group.

2. The electrode sheet according to claim 1, characterized in that: Each of the electrode units further includes a diode connected in series with the temperature sensor, and the temperature sensor is grounded through the diode connected in series with the temperature sensor.

3. The electrode sheet according to claim 1, characterized in that: The dual-purpose signal line is selectively connected to an AC signal or a temperature measurement DC signal. When measuring temperature, multiple dual-purpose signal lines are individually connected to the DC signal in sequence, and multiple grounding lines are turned on one by one in sequence; when applying an AC signal, multiple dual-purpose signal lines are fully or partially connected to the AC signal, and multiple grounding lines are all disconnected.

4. The electrode sheet according to claim 1, characterized in that: The plurality of electrode units are divided into four rows and five columns, three rows and five columns, four rows and four columns, three rows and four columns, or three rows and three columns on the circuit.

5. The electrode sheet according to claim 4, characterized in that: The number of electrode units in each row is less than or equal to the number of column groups.

6. The electrode sheet according to claim 1, characterized in that: The plurality of electrode units are structurally arranged into a plurality of rows and columns, the flexible circuit board is provided with a connection portion connecting two adjacent electrode units, wherein the electrode sheet is provided with a gap formed between two adjacent electrode units along the column direction and along the row direction.

7. A tumor electric field treatment system, characterized in that: It comprises at least one pair of electrode sheets according to any one of claims 1 to 4.

8. The tumor electric field treatment system according to claim 7, characterized in that: It also includes an electric field generator and an adapter electrically connected between the electrode sheet and the electric field generator, the adapter includes multiple groups of bidirectional switching switches and multiple groups of grounding switches, each group of bidirectional switching switches is arranged in a one-to-one correspondence with each of the electrode sheets, and the multiple dual-purpose signal lines of the electrode sheet are electrically connected one-to-one with the corresponding bidirectional switching switches of the corresponding row group, and the number of each group of bidirectional switching switches is equal to the number of the dual-purpose signal lines of the corresponding electrode sheet; each group of grounding switches is arranged in a one-to-one correspondence with each of the electrode sheets, and the multiple grounding lines of the electrode sheet are electrically connected one-to-one with the corresponding grounding switches of the corresponding column group, and the number of each group of grounding switches is equal to the number of the grounding lines of the corresponding electrode sheet.

9. The tumor electric field treatment system according to claim 8, characterized in that: The adapter includes an AC signal line, and the AC signal line is configured to provide an alternating current signal to each of the electrode units in the corresponding row group through a plurality of dual-purpose signal lines.

10. The tumor electric field treatment system according to claim 9, characterized in that: The adapter also includes multiple groups of analog-to-digital converters, each group of analog-to-digital converters is arranged corresponding to each of the electrode sheets and includes multiple detection channels, and each of the two-way switching switches has a first end electrically connected to the corresponding detection channel and a second end electrically connected to the AC signal line; when measuring temperature, multiple two-way switching switches are individually placed at their first ends, and the remaining two-way switching switches are all placed at the second ends, and the multiple grounding switches electrically connected to the electrode sheets are turned on one by one; when an alternating current signal is applied, all or part of the multiple two-way switching switches electrically connected to the electrode sheets are placed at the second end, and the multiple grounding switches electrically connected to the electrode sheets are all disconnected.

11. The tumor electric field treatment system according to claim 10, characterized in that: The adapter also includes a first controller, which is electrically connected to multiple groups of grounding switches respectively and is configured to: control the opening and closing states of each grounding switch in each group in sequence and cycle, thereby sequentially connecting each grounding line corresponding to the electrode sheet one by one.

12. The tumor electric field treatment system according to claim 11, characterized in that: The first controller is connected to a plurality of groups of bidirectional switches respectively, and is configured to control the switching state of the plurality of bidirectional switches in each group so that the bidirectional switches are placed at the first end or the second end.

13. A temperature detection method for a tumor electric field treatment system, characterized in that: Applied to the electrode sheet as described in any one of claims 1 to 6 or to the tumor electric field treatment system as described in any one of claims 7 to 12, the method comprises the following steps: sequentially and individually connecting multiplexed signal lines corresponding to the multiple row groups of the corresponding electrode sheet to direct current signals; and sequentially and time-sharingly conducting each of the multiple grounding lines corresponding to the multiple column groups of the corresponding electrode sheet to collect the temperature detection signals of each of the electrode units in each row group of the electrode sheet by row through the multiplexed signal lines.

14. A signal control method for tumor electric field therapy, characterized in that: Applied to the electrode sheet according to any one of claims 1 to 6 or to the tumor electric field therapy system according to any one of claims 7 to 12, the tumor electric field therapy signal is achieved by combining and controlling the conduction and disconnection of multiple dual-purpose signal lines and multiple grounding lines, and the electrode units of the electrode sheet are cyclically switched between applying an alternating current signal or transmitting a temperature detection signal through the multiple dual-purpose signal lines; wherein The process of applying an alternating current signal to each electrode unit of the electrode sheet comprises the following steps: disconnecting the multiple grounding lines electrically connected to the electrode units of each column group of the electrode sheet one by one, and simultaneously connecting the multiple dual-purpose signal lines electrically connected to the electrode units of each row group of the electrode sheet one by one so that the multiple dual-purpose signal lines electrically connected to the electrode sheet transmit the alternating current signal to each electrode unit; The process of enabling each electrode unit of the electrode sheet to transmit a temperature detection signal includes the following steps: sequentially and individually connecting the multiple dual-purpose signal lines electrically connected one by one to the electrode units of each row group of the electrode sheet to a direct current signal; and sequentially and time-sharingly conducting one grounding line among the multiple grounding lines electrically connected one by one to the electrode units of each column group of the electrode sheet to complete the transmission of the temperature detection signal of each electrode unit of the electrode sheet row by row through the multiple dual-purpose signal lines electrically connected to the electrode sheet.

15. The signal control method for tumor electric field therapy according to claim 14, characterized in that: During the process of applying alternating current signals to the electrode units of the electrode sheet, the row group to which the electrode unit to which the alternating current signal needs to be applied is determined according to the area where the electrode unit is located, and the alternating current signal is transmitted to the corresponding dual-purpose signal line electrically connected to the electrode unit in the row group, and the other dual-purpose signal lines stop transmitting the alternating current signal.

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