Preparation method of hydrogen-based blasting bead for removing free radicals in cigarette smoke

Abstract

The invention discloses a preparation method of a hydrogen-based blasting bead for removing free radicals in cigarette smoke, which comprises the following steps: step 1, weighing a hydrolysis hydrogen production material and low-molecular-weight polyethylene glycol in a mass ratio of 1: (100-500), mixing the hydrolysis hydrogen production material and the low-molecular-weight polyethylene glycol, performing ultrasonic treatment for 30-60 minutes, standing for 6-12 hours, and taking an upper turbid liquid as a core material of the hydrogen-producing blasting bead; step 2, taking a prepolymer, a diluent and a photoinitiator as wall materials and a core material of the hydrogen-producing blasting bead obtained in the step 1, and preparing the hydrogen-producing blasting bead through a millifluidics method in an external phase solution; and step 3, preparing the high-water-content blasting bead from the core material and the wall material of the high-water-content blasting bead in an external phase solution through a millifluidics method. The hydrogen-producing blasting beads are prepared by taking the hydrolysis hydrogen production material dispersed in liquid organic matters such as polyethylene glycol as the core material and the light-cured resin as the wall material, and the hydrogen-producing blasting beads are combined with the blasting beads of the high-water-content core material for use to prepare the hydrogen-based blasting bead filter tip containing the double blasting beads, so that the effects of simultaneously smoking and absorbing hydrogen and reducing the damage of free radicals of smoke to the body are achieved.

Description

Technical Field

[0001] The invention relates to the technical field of cigarette additives, in particular to a method for preparing hydrogen-based explosive beads for removing free radicals from cigarette smoke. Background Art

[0002] Smoking is harmful to health, and one of the most harmful components to the human body is free radicals. Each puff of smoke produces about 1×10 16 Free radicals in cigarette smoke are generally divided into gas-phase free radicals and solid-phase free radicals. The solid-phase free radicals are mainly quinone / semiquinone free radicals and condensed aromatic hydrocarbon free radicals. Most of the solid-phase free radicals can be filtered out with ordinary acetate filter tips, but the solid-phase free radicals that enter the body can also undergo self-oxidation reactions to generate a series of active oxygen free radicals such as hydroxyl free radicals.

[0003] Gas-phase free radicals are very active and short-lived, mainly alkyl free radicals and alkoxy free radicals. When the human body ingests excessive amounts of active free radicals, they will attack cells, causing abnormal metabolism of proteins, fats, and nucleotides, and causing diseases. In order to reduce the harm of free radicals in smoke to smokers, a common method at home and abroad is to add antioxidants, including natural plant extracts and minerals, to filters or tobacco shreds. However, there are still problems such as low efficiency in scavenging free radicals and the generation of new harmful components. (Wang Jilian et al., Research Progress on Free Radical Scavenging in Cigarette Smoke, Food Industry Science and Technology, 2012, 10, 158)

[0004] Hydrogen molecules have weak reducing properties and can react with active free radicals to eliminate them. They have many beneficial effects on the human body and even have certain therapeutic effects on many diseases. Hydrogen health has thus become an important research and application field (Shigeo Ohta et al., Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals, Nature Medicine, 2007, 13, 688; Jiang Xue et al., Progress in clinical research on the application of hydrogen molecules in disease treatment, Journal of Shandong First Medical University (Shandong Academy of Medical Sciences), 2023, 44).

[0005] If you inhale a small amount of hydrogen while smoking cigarettes, you can significantly eliminate the active free radicals brought by the smoke and reduce the health hazards of smoking, but there is currently no relevant technology.

[0006] "Exploding beads" refer to small liquid beads embedded in the tobacco filter, which are wrapped with liquids of different types of flavors. Smokers can pinch and burst the beads during smoking to make the liquid in the beads flow out, making the cigarette taste richer and more fragrant, giving smokers a more comfortable experience.

[0007] In the early days, the explosive beads were made of oily core materials (oil-soluble flavors, glyceryl stearate, etc.) and water-soluble wall materials (gelatin, gum arabic, alginate, etc.). In recent years, explosive beads with water-based core materials (water-soluble flavors, water, etc.) and oil-soluble wall materials (photocurable resins such as polylactic acid, polyethylene, and polyurethane acrylate, etc.) have also appeared in large numbers.

[0008] Active metals and their hydrides (magnesium, magnesium hydride, calcium hydride), etc. can react with water to produce hydrogen, and their applications in the field of hydrogen health are also being studied. For example, Cong Xu et al. used hyaluronic acid-coated magnesium powder to react with water to slowly release hydrogen and used it to treat inflammation (Nano Lett. 2021, 21, 1982). Fei Gong et al. reacted polyethylene glycol-dispersed nano-calcium hydride with water to slowly release hydrogen and used it for synergistic treatment of tumors. However, their application in tobacco explosive beads is still blank, so a method for preparing hydrogen-based explosive beads for removing free radicals in cigarette smoke is provided. Summary of the invention

[0009] The purpose of the present invention is to provide a method for preparing hydrogen-based explosive beads for removing free radicals in cigarette smoke in view of the defects of the prior art, so as to solve the problems raised by the above-mentioned background technology.

[0010] To achieve the above object, the present invention provides the following technical solution: a method for preparing hydrogen-based explosive beads for removing free radicals in cigarette smoke, the specific steps are as follows:

[0011] Step 1: Weigh the hydrolysis hydrogen production material and low molecular weight polyethylene glycol in a mass ratio of 1:100-500, mix the two, sonicate for 30-60 minutes, let stand for 6-12 hours, and take the upper suspension as the core material of the hydrogen production explosion beads;

[0012] Step 2: using the prepolymer, diluent and photoinitiator as the wall material and the core material of the hydrogen-generating explosive beads obtained in step 1, and preparing the hydrogen-generating explosive beads by millifluidic method under the external phase solution;

[0013] Step 3: Prepare the high water content explosive beads by millifluidic method under the external phase solution.

[0014] As a preferred technical solution of the present invention, the hydrolysis hydrogen production material includes but is not limited to magnesium, calcium and their hydrides; the molecular weight of the polyethylene glycol is 200-600.

[0015] As a preferred technical solution of the present invention, the wall materials in step 2 and step 3 are prepolymer, diluent and photoinitiator, and the mass ratio of the three is 70-99:0-20:1-10;

[0016] As a preferred technical solution of the present invention, the prepolymer is a polyurethane acrylate prepolymer; the diluent is hydroxyethyl acrylate; and the photoinitiator is diphenyl-(2,4,6-trimethylbenzoyl)phosphine oxide.

[0017] As a preferred technical solution of the present invention, the core material of the high water content bursting beads in step 3 is Chinese herbal medicine extract, low molecular weight polyethylene glycol, and distilled water, and the mass ratio of the three is 0-1:0-5:94-100.

[0018] As a preferred technical solution of the present invention, the external phase solution in step 2 and step 3 is an oily liquid.

[0019] As a preferred technical solution of the present invention, the oily liquid is silicone oil and peanut oil.

[0020] As a preferred technical solution of the present invention, in step 2 and step 3, the explosive beads are prepared by the millifluidic method, and the specific steps are as follows:

[0021] The core material solution and the wall material are weighed separately, and the core material, the wall material and the external phase liquid are loaded into the liquid pump respectively; the liquid pump loaded with the core material, the wall material and the external phase liquid are connected to the inner phase, the middle phase and the external phase needles respectively, and the inner phase needle, the middle phase needle and the external phase needle together form a coaxial needle; the coaxial needle is connected to the curing tube filled with the external phase liquid, and the coaxial needle is immersed below the liquid level of the external phase liquid in the curing tube, and ultraviolet lamp beads are arranged on both sides of the curing tube, and the core material, the wall material and the external phase liquid are extruded through the coaxial needle at the same time, and the extrudate passes through the curing tube and is solidified in the curing tube, and the water bursting beads are collected at the bottom of the curing tube.

[0022] A hydrogen-based bursting bead filter for removing free radicals from cigarette smoke is prepared by combining hydrogen-producing bursting beads and high-water-content bursting beads prepared by a preparation method with a filter cotton core, a microporous filter and a soft gel cavity to form a filter.

[0023] Compared with the prior art, the present invention has the following beneficial effects:

[0024] The present invention prepares hydrogen-producing bursting beads by using hydrolysis hydrogen-producing materials (including but not limited to magnesium, calcium and their hydrides) dispersed in liquid organic matter such as polyethylene glycol (molecular weight 200-600) as core material and photocurable resin as wall material, and uses them in combination with bursting beads with high water content core material to prepare hydrogen-based bursting bead filter containing double bursting beads, thereby achieving the effect of smoking and absorbing hydrogen at the same time and reducing the damage of smoke free radicals to the body.

[0025] Moreover, the popping beads with high water content core material can be added with purified Chinese medicinal ingredients (tangerine peel, ginseng, etc.) to further reduce the harm of smoking.

[0026] (1) For the first time, the efficacy of hydrogen molecules in eliminating active free radicals was applied to eliminate free radicals in cigarette smoke;

[0027] (2) The hydrogen-producing blasting beads were invented for the first time and used together with high-water-content blasting beads to achieve the effect of instant and slow hydrogen production, allowing for simultaneous smoking and hydrogen inhalation. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 It is a schematic diagram of the structure of the hydrogen-based bursting bead filter of the present invention;

[0029] In the picture: 1. Conical head; 2. Soft gel cavity; 3. Hydrogen-producing blasting beads; 4. High water content blasting beads

[0030] Figure 2 This is a gas chromatogram of the gas produced after the hydrogen-producing explosion beads and the high-water-content explosion beads are squeezed and exploded together in Example 1 of the present invention;

[0031] Figure 3 This is a gas chromatogram of the gas produced after the hydrogen-producing explosion beads and the high-water-content explosion beads are squeezed and exploded together in Example 2 of the present invention;

[0032] Figure 4 This is a gas chromatogram of the gas produced after the hydrogen-producing explosion beads and the high-water-content explosion beads are squeezed and exploded together in Example 3 of the present invention. DETAILED DESCRIPTION

[0033] The preferred embodiments of the present invention are described in detail below in conjunction with the accompanying drawings so that the advantages and features of the present invention can be more easily understood by those skilled in the art, thereby making a clearer and more definite definition of the protection scope of the present invention.

[0034] Example 1: Magnesium hydride powder and polyethylene glycol with a molecular weight of 200 were weighed in a mass ratio of 1:100, mixed, ultrasonicated for 30 minutes, and allowed to stand for 6 hours;

[0035] The upper suspension was used as the core material of hydrogen-producing explosive beads, a mixture of 99 wt% of polyurethane acrylate prepolymer and 1 wt% of diphenyl-(2,4,6-trimethylbenzoyl)phosphine oxide was used as the wall material, and silicone oil with a viscosity of 100 mPa·s was used as the external phase, and hydrogen-producing explosive beads were prepared by millifluidics;

[0036] High-water-content explosive beads were prepared by millifluidics with distilled water as the core material, 97wt% polyurethane acrylate prepolymer and 3wt% diphenyl-(2,4,6-trimethylbenzoyl)phosphine as the wall material, and silicone oil with a viscosity of 100mPa·s as the external phase.

[0037] The obtained hydrogen-producing explosive beads and high-water-containing explosive beads are separated into hydrogen-producing explosive beads and high-water-containing explosive beads according to Figure 1 The schematic diagram of the structure is assembled into a hydrogen-based bursting bead filter.

[0038] Connect the hydrogen-based bursting bead filter to the high-purity nitrogen pipeline, connect a drying tube to the back, and then connect to the gas chromatograph. Use high-purity nitrogen to purge the air in the gas line, then squeeze the two bursting beads in the filter, continue to purge with high-purity nitrogen, and analyze the gas components with a gas chromatograph after 1 minute. The results are as follows: Figure 2 , we can see that hydrogen is indeed produced.

[0039] Example 2: Magnesium powder and polyethylene glycol with a molecular weight of 600 were weighed in a mass ratio of 1:500, mixed, ultrasonicated for 60 minutes, and allowed to stand for 12 hours.

[0040] The upper suspension was taken as the core material of hydrogen-producing explosive beads, 70wt% of polyurethane acrylate prepolymer, 20wt% of hydroxyethyl acrylate and 10wt% of diphenyl-(2,4,6-trimethylbenzoyl)phosphine oxide mixture was used as the wall material, and peanut oil was used as the external phase, and hydrogen-producing explosive beads were prepared by millifluidic method.

[0041] High-water-content explosive beads were prepared by millifluidics using a solution formed by 1wt% tangerine peel extract and 99wt% distilled water as the core material, 85wt% polyurethane acrylate prepolymer, 10wt% hydroxyethyl acrylate and 5wt% diphenyl-(2,4,6-trimethylbenzoyl)phosphine as the wall material, and peanut oil as the external phase.

[0042] The hydrogen-producing blasting beads and high-water-content blasting beads are divided into Figure 1 The schematic diagram of the structure is assembled into a hydrogen-based bursting bead filter.

[0043] Connect the hydrogen-based bursting bead filter to the high-purity nitrogen pipeline, connect a drying tube to the back, and then connect to the gas chromatograph. Use high-purity nitrogen to purge the air in the gas line, then squeeze the two bursting beads in the filter, continue to purge with high-purity nitrogen, and analyze the gas components with a gas chromatograph after 1 minute. The results are as follows: Figure 3 , we can see that hydrogen is indeed produced.

[0044] Example 3: Calcium hydride and polyethylene glycol with a molecular weight of 400 were weighed in a mass ratio of 1:300, mixed, ultrasonicated for 45 minutes, and allowed to stand for 9 hours.

[0045] The upper suspension was taken as the core material of hydrogen-producing explosive beads, 90wt% of polyurethane acrylate prepolymer, 8wt% of hydroxyethyl acrylate and 2wt% of diphenyl-(2,4,6-trimethylbenzoyl)phosphine oxide mixture was used as the wall material, and peanut oil was used as the external phase, and hydrogen-producing explosive beads were prepared by millifluidic method.

[0046] High-water-content explosive beads were prepared by millifluidics using a solution of 1wt% ginseng extract, 5wt% polyethylene glycol with a molecular weight of 400 and 94wt% distilled water as the core material, 95wt% polyurethane acrylate prepolymer, 2wt% hydroxyethyl acrylate and 3wt% diphenyl-(2,4,6-trimethylbenzoyl)phosphine as the wall material, and peanut oil as the external phase.

[0047] The hydrogen-producing blasting beads and high-water-content blasting beads are divided into Figure 1 The schematic diagram of the structure is assembled into a hydrogen-based bursting bead filter.

[0048] Connect the hydrogen-based bursting bead filter to the high-purity nitrogen pipeline, connect a drying tube to the back, and then connect to the gas chromatograph. Use high-purity nitrogen to purge the air in the gas line, then squeeze the two bursting beads in the filter, continue to purge with high-purity nitrogen, and analyze the gas components with a gas chromatograph after 1 minute. The results are as follows: Figure 4 , we can see that hydrogen is indeed produced.

[0049] The above embodiments only express the implementation methods of the present invention, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the invention patent. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention.

Claims

1. A method for preparing hydrogen-based explosive beads for removing free radicals from cigarette smoke, characterized in that: The specific steps are as follows: Step 1: Weigh the hydrolysis hydrogen production material and low molecular weight polyethylene glycol in a mass ratio of 1:100-500, mix the two, sonicate for 30-60 minutes, let stand for 6-12 hours, and take the upper suspension as the core material of the hydrogen production explosion beads; Step 2: using the prepolymer, diluent and photoinitiator as the wall material and the core material of the hydrogen-generating explosive beads obtained in step 1, and preparing the hydrogen-generating explosive beads by millifluidic method under the external phase solution; Step 3: Prepare the high water content explosive beads by millifluidic method under the external phase solution.

2. The method for preparing hydrogen-based explosive beads for removing free radicals from cigarette smoke according to claim 1, characterized in that: The hydrolysis hydrogen production material includes but is not limited to magnesium, calcium and their hydrides; the molecular weight of the polyethylene glycol is 200-600.

3. The method for preparing hydrogen-based explosive beads for removing free radicals from cigarette smoke according to claim 1, characterized in that: The wall materials in step 2 and step 3 are prepolymer, diluent and photoinitiator, and the mass ratio of the three is 70-99:0-20:1-10.

4. The method for preparing hydrogen-based explosive beads for removing free radicals from cigarette smoke according to claim 3, characterized in that: The prepolymer is a polyurethane acrylate prepolymer; the diluent is hydroxyethyl acrylate; and the photoinitiator is diphenyl-(2,4,6-trimethylbenzoyl)phosphine oxide.

5. The method for preparing hydrogen-based explosive beads for removing free radicals from cigarette smoke according to claim 1, characterized in that: In step 3, the core material of the high water content bursting beads is Chinese herbal medicine extract, low molecular weight polyethylene glycol, and distilled water, and the mass ratio of the three is 0-1:0-5:94-100.

6. The method for preparing hydrogen-based explosive beads for removing free radicals from cigarette smoke according to claim 1, characterized in that: The external phase solution in step 2 and step 3 is an oily liquid.

7. The method for preparing hydrogen-based explosive beads for removing free radicals from cigarette smoke according to claim 6, characterized in that: The oily liquid is silicone oil and peanut oil.

8. The method for preparing hydrogen-based explosive beads for removing free radicals from cigarette smoke according to claim 1, characterized in that: In step 2 and step 3, the explosive beads are prepared by millifluidics, and the specific steps are as follows: The core material solution and the wall material are weighed separately, and the core material, the wall material and the external phase liquid are loaded into the liquid pump respectively; the liquid pump loaded with the core material, the wall material and the external phase liquid are connected to the inner phase, the middle phase and the external phase needles respectively, and the inner phase needle, the middle phase needle and the external phase needle together form a coaxial needle; the coaxial needle is connected to the curing tube filled with the external phase liquid, and the coaxial needle is immersed below the liquid level of the external phase liquid in the curing tube, and ultraviolet lamp beads are arranged on both sides of the curing tube, and the core material, the wall material and the external phase liquid are extruded through the coaxial needle at the same time, and the extrudate passes through the curing tube and is solidified in the curing tube, and the water bursting beads are collected at the bottom of the curing tube.

9. A hydrogen-based burst bead filter for removing free radicals from cigarette smoke, characterized in that: The hydrogen-producing explosive beads and high-water-content explosive beads prepared by the preparation method described in any one of claim 1 are combined with a filter cotton core, a microporous filter and a soft gel cavity to form a filter tip.

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