Roller valves, switching devices and immunoadsorption devices

Abstract

The present application provides a rolling valve, a switching device and an immunoadsorption device, which relate to the field of blood purification technology. The rolling valve includes an annular hose, an extrusion rod and a plurality of connectors located in a shell. The outer wall of the annular hose includes a proximal outer wall located on one side of the ring center and an opposite distal outer wall. A plurality of connectors are arranged on the distal outer wall at intervals around the ring center and are all connected to the annular hose. The annular hose is arranged on the inner bottom wall of the shell and the distal outer wall abuts against the inner wall of the shell. Each connector passes through the shell. The extrusion rod is rotatably arranged on the inner bottom wall of the shell. Both ends of the extrusion rod abut against the proximal outer wall and squeeze the proximal outer wall toward the inner wall of the shell, so that the internal space of the annular hose is divided into two subspaces by the extrusion rod, and all connectors connected to the same subspace are interconnected. Based on this, the rolling valve can be used in an immunoadsorption system with dual adsorption columns to reduce the amount of operations required by medical staff when switching between the dual adsorption columns.

Description

Technical Field

[0001] The present application relates to the technical field of blood purification, and in particular to a roller valve, a switching device and an immunoadsorption device. Background Art

[0002] Blood purification is a technique that uses extracorporeal circulation to remove certain pathogenic substances from a patient's blood. Specifically, the patient's blood is drawn out of the body, purified (i.e., removing certain pathogenic substances from the blood) through a purification device, and then returned to the patient's body, ultimately achieving the goal of treating diseases such as kidney disease, poisoning, autoimmune diseases, and liver disease. There are many methods for blood purification, such as hemodialysis, hemofiltration, hemoperfusion, plasma exchange, and immunoadsorption, but in recent years, immunoadsorption has become increasingly widely used.

[0003] Immunoadsorption involves combining highly specific antigens, antibodies, or substances with specific physical and chemical affinities (called ligands) with an adsorption material (called a carrier) to form an adsorbent. This adsorbent is then loaded into a column to create an adsorption column. The column selectively or specifically adsorbs pathogenic substances from the blood, thereby purifying the blood and treating the disease. However, the adsorption column has a limited capacity for adsorption of pathogenic substances, typically requiring multiple adsorption cycles to achieve a therapeutic effect. This results in prolonged treatment for patients. After each adsorption cycle, the column requires a lengthy flushing (a process called regeneration). While this can remove adsorbed pathogens and facilitate the next adsorption cycle, it also further increases treatment time.

[0004] In the related art, two adsorption columns are provided in the immunoadsorption system, and several pipes are connected between the two adsorption columns. These pipes are provided with multiple tube clamps. The switching between the two adsorption columns is achieved by controlling the multiple tube clamps, so that the immunoadsorption system is always in a working state of "one adsorption column adsorbs pathogenic substances and the other adsorption column regenerates". Although this can reduce the patient's treatment time, each switching requires the simultaneous control of multiple tube clamps. The medical staff has a large amount of operation and is prone to errors. At the very least, it will affect the patient's treatment process, and at worst, it will endanger the patient's life. Summary of the Invention

[0005] The present application provides a rolling valve, a switching device and an immunoadsorption device, which aim to solve the problems of large amount of operations and high error rate when medical staff switch between dual adsorption columns in related technologies.

[0006] In order to solve the above-mentioned drawbacks existing in the related art, the first aspect of the present application provides a rolling valve, comprising an annular hose and a plurality of connectors, the outer wall of the annular hose comprising a proximal outer wall located on one side of the annular center and an opposite distal outer wall, a plurality of connectors being arranged on the distal outer wall at intervals around the annular center and all being connected to the annular hose. The rolling valve also comprises an extrusion rod and a hollow shell, the extrusion rod, the annular hose and the plurality of connectors being all located within the shell, the annular hose being arranged on the inner bottom wall of the shell, and the distal outer wall being in contact with the inner side wall of the shell, the end of each connector away from the annular hose being passed through the shell and being used to connect to an external pipe, a rotating shaft being arranged on the inner bottom wall of the shell, the extrusion rod being arranged on the rotating shaft and being rotatably matched with the rotating shaft, the opposite ends of the extrusion rod being in contact with the proximal outer wall and squeezing the proximal outer wall toward the inner side wall of the shell, so that the internal space of the annular hose is divided into two subspaces by the extrusion rod, and all connectors connected to the same subspace are interconnected. The extrusion rod is used to rotate around the rotation axis under the action of external force to adjust the joints communicating with each subspace and change the flow direction of the liquid entering the annular hose through the pipeline.

[0007] In some implementations, an operating window communicating with the interior is provided on the outer wall of the housing, and the operating window corresponds to the extrusion rod; or, a through hole communicating with the interior is provided on the outer wall of the housing, and the through hole corresponds to the extrusion rod. The rolling valve further includes a knob and a connecting rod, wherein the knob is provided on one end of the connecting rod, and the other end of the connecting rod passes through the hole and enters the housing and is provided on the extrusion rod. In one implementation, the knob includes a base, one side of the base is connected to the connecting rod, and a handle is formed on the other opposite side, wherein the length direction of the handle is consistent with the axis direction of the extrusion rod; further, a plurality of marking points are provided on the housing at intervals around the knob, and the marking points at different positions on the housing correspond to different valve states of the rolling valve. Different valve states have different connectors connected to each subspace. The marking points are used to indicate to the user the current valve state of the rolling valve when the end of the handle is aligned with itself.

[0008] In some implementation schemes, the rolling valve also includes two rollers, both of which are rotatably set on the extrusion rod. The two rollers are respectively located on both sides of the rotating shaft. The rollers are in contact with the inner bottom wall of the shell. The rollers are used to roll on the inner bottom wall of the shell when the extrusion rod rotates around the rotating shaft.

[0009] In some implementation schemes, an annular groove surrounding the rotating shaft is opened on the inner bottom wall of the shell, and two sliders are slidingly arranged in the annular groove. Both sliders are connected to the extrusion rod and are respectively located on both sides of the rotating shaft. The sliders are used to slide in the annular groove when the extrusion rod rotates around the rotating shaft.

[0010] In some implementations, the annular hose is in the shape of a donut.

[0011] The second aspect of the present application provides a switching device, which is used in an immunoadsorption device. The immunoadsorption device includes a plasma separation device, a flushing device, a left adsorption column, a right adsorption column and a waste liquid bag. The two ends of the plasma separation device are respectively used to connect the patient's artery and vein. The switching device includes a first roller valve and a second roller valve. The first roller valve and the second roller valve are both the roller valves mentioned in the first aspect of the present application. The first roller valve has a first joint, a second joint, a third joint and a fourth joint. The second roller valve has a fifth joint, a sixth joint, a seventh joint and an eighth joint. The two ends of the left adsorption column are respectively connected to the second joint and the sixth joint. The plasma separation device is connected to the first joint. The fifth joint is used to connect to the vein. The two ends of the right adsorption column are respectively connected to the third joint and the seventh joint. The flushing device is connected to the fourth joint. The waste liquid bag is connected to the eighth joint. Among them, the plasma separation device is used to draw blood from the artery and separate plasma; the flushing device is used to provide flushing fluid; the switching device is used to adjust the working state of the immunoadsorption device by rotating the extrusion rods in the first roller valve and the second roller valve.

[0012] Specifically, the working states include a left column adsorption state and a right column adsorption state. In the left column adsorption state, the first connector is connected to the second connector, the fifth connector is connected to the sixth connector, the third connector is connected to the fourth connector, and the seventh connector is connected to the eighth connector. The flow path of the plasma is the first connector, the second connector, the left adsorption column, the sixth connector, the fifth connector and the vein, and the flow path of the flushing liquid is the fourth connector, the third connector, the right adsorption column, the seventh connector, the eighth connector and the waste liquid bag; in the right column adsorption state, the first connector is connected to the third connector, the fifth connector is connected to the seventh connector, the second connector is connected to the fourth connector, and the sixth connector is connected to the eighth connector. The flow path of the plasma is the first connector, the third connector, the right adsorption column, the seventh connector, the fifth connector and the vein, and the flow path of the flushing liquid is the fourth connector, the second connector, the left adsorption column, the sixth connector, the eighth connector and the waste liquid bag.

[0013] The third aspect of the present application provides an immunoadsorption device, including a plasma separation device, a flushing device, a left adsorption column, a right adsorption column, a waste liquid bag and the switching device mentioned in the second aspect of the present application. The two ends of the plasma separation device are respectively used to connect the patient's artery and vein, the first roller valve in the switching device has a first connector, a second connector, a third connector and a fourth connector, the second roller valve in the switching device has a fifth connector, a sixth connector, a seventh connector and an eighth connector, the two ends of the left adsorption column are respectively connected to the second connector and the sixth connector, the plasma separation device is connected to the first connector, the fifth connector is used to connect to the vein, the two ends of the right adsorption column are respectively connected to the third connector and the seventh connector, the flushing device is connected to the fourth connector, and the waste liquid bag is connected to the eighth connector. Among them, the plasma separation device is used to draw blood from the artery and separate plasma; the flushing device is used to provide flushing fluid; the switching device is used to adjust the working state of the immunoadsorption device by rotating the extrusion rods in the first roller valve and the second roller valve;

[0014] Specifically, the working states include a left column adsorption state and a right column adsorption state. In the left column adsorption state, the first connector is connected to the second connector, the fifth connector is connected to the sixth connector, the third connector is connected to the fourth connector, and the seventh connector is connected to the eighth connector. The flow path of the plasma is the first connector, the second connector, the left adsorption column, the sixth connector, the fifth connector and the vein, and the flow path of the flushing liquid is the fourth connector, the third connector, the right adsorption column, the seventh connector, the eighth connector and the waste liquid bag; in the right column adsorption state, the first connector is connected to the third connector, the fifth connector is connected to the seventh connector, the second connector is connected to the fourth connector, and the sixth connector is connected to the eighth connector. The flow path of the plasma is the first connector, the third connector, the right adsorption column, the seventh connector, the fifth connector and the vein, and the flow path of the flushing liquid is the fourth connector, the second connector, the left adsorption column, the sixth connector, the eighth connector and the waste liquid bag.

[0015] In some implementations, the plasma separation device includes a first blood pump and a plasma separator, one end of the plasma separator being connected to the first blood pump, which is connected to an artery, and the other end of the plasma separator being connected to a vein, and the plasma separator being further connected to a first connector. The first blood pump is configured to draw blood from the artery and pump it to the plasma separator, and the plasma separator is configured to separate plasma from the blood.

[0016] In one embodiment, the plasma separator further includes an arterial and venous chambers. One end of the plasma separator is connected to the first blood pump via the arterial chamber, and the other end is connected to a vein via the venous chamber. The venous chamber is connected to a fifth connector. In one embodiment, the plasma separator further includes a second blood pump connected between the plasma separator and the first connector to draw plasma from the plasma separator and pump it to the first connector.

[0017] In some implementation schemes, the flushing liquid includes an elution liquid, a balancing liquid and a pre-flushing liquid, and the flushing device includes an elution bag, a balancing bag and a pre-flushing bag, and the elution bag, the balancing bag and the pre-flushing bag are respectively connected to the fourth joint; specifically, the elution bag is used to store the elution liquid, the balancing bag is used to store the balancing liquid, and the pre-flushing bag is used to store the pre-flushing liquid. In one implementation scheme, the flushing device also includes a third blood pump, an elution switch, a balance switch and a pre-flush switch. The elution bag is connected to the third blood pump through the elution switch, the balance bag is connected to the third blood pump through the balance switch, the pre-flush bag is connected to the third blood pump through the pre-flush switch, and the third blood pump is connected to the fourth connector. Specifically, the elution switch is used to connect the third blood pump and the elution bag when it is turned on, or to block the third blood pump and the elution bag when it is turned off. The balance switch is used to connect the third blood pump and the balance bag when it is turned on, or to block the third blood pump and the balance bag when it is turned off. The pre-flush switch is used to connect the third blood pump and the pre-flush bag when it is turned on, or to block the third blood pump and the pre-flush bag when it is turned off. The third blood pump is used to draw eluent from the elution bag and pump it to the fourth connector when the elution switch is turned on, or to draw balance liquid from the balance bag and pump it to the fourth connector when the balance switch is turned on, or to draw pre-flush liquid from the pre-flush bag and pump it to the fourth connector when the pre-flush switch is turned on.

[0018] The rolling valve provided in the first aspect of the present application includes a hollow shell and an annular hose, an extrusion rod and multiple joints located in the shell. The outer wall of the annular hose includes a proximal outer wall located on one side of the ring center and an opposite distal outer wall. Multiple joints are arranged on the distal outer wall at intervals around the ring center and are all connected to the annular hose. The annular hose is arranged on the inner bottom wall of the shell and the distal outer wall abuts against the inner wall of the shell. One end of each joint away from the annular hose passes through the shell and is used to connect to an external pipe. A rotating shaft is provided on the inner bottom wall of the shell, and the extrusion rod is rotatably provided on the rotating shaft. The opposite ends of the extrusion rod abut against the proximal outer wall and squeeze the proximal outer wall toward the inner wall of the shell, so that the internal space of the annular hose is divided into two sub-spaces by the extrusion rod, and all joints connected to the same sub-space are interconnected. In actual applications, the extrusion rod can be rotated around the rotating axis. Since the annular hose is fixed, the position on the annular hose squeezed by the extrusion rod will change during the rotation of the extrusion rod, which will cause the joint connected to each subspace to change. Then, the flow direction of the liquid entering the annular hose through the pipeline will naturally change accordingly. Based on this, at least one roller valve can be used in an immunoadsorption system including two adsorption columns. Specifically, at least one roller valve can be set in a pipe network connecting the two adsorption columns, and multiple connectors of the roller valve can be connected to several pipes in the pipe network respectively. In this way, the flow direction of the plasma or flushing fluid entering the roller valve can be adjusted by rotating the extrusion rod in the roller valve, thereby realizing switching between the two adsorption columns for adsorption work (i.e., adsorption of pathogenic substances in the plasma), so that when one adsorption column is performing adsorption work, the other adsorption column is performing regeneration work (i.e., flushing the adsorption column with flushing fluid). The switching of the present application only requires rotating the extrusion rod in the roller valve, and there is no need to control multiple tube clamps at the same time as in the traditional solution. This not only reduces the amount of operation for medical staff, but also reduces the error rate of medical staff during operation.

[0019] For the switching device provided in the second aspect of the present application, it includes a first roller valve and a second roller valve. The first roller valve and the second roller valve are both roller valves provided in the first aspect of the present application. The first roller valve has four connectors (i.e., a first connector, a second connector, a third connector, and a fourth connector), and the second roller valve also has four connectors (i.e., a fifth connector, a sixth connector, a seventh connector, and an eighth connector). When the switching device is applied to an immunoadsorption device including a plasma separation device, a flushing device, a waste liquid bag, and two adsorption columns (i.e., a left adsorption column and a right adsorption column), the two ends of the left adsorption column are respectively connected to the second connector and the sixth connector, the plasma separation device is connected to the first connector, the fifth connector is used to connect to the patient's vein, the two ends of the right adsorption column are respectively connected to the third connector and the seventh connector, the flushing device is connected to the fourth connector, and the waste liquid bag is connected to the eighth connector. In actual applications, the plasma separation device can draw blood from the patient's artery and separate plasma, and the flushing device can provide flushing fluid. When the immunoadsorption device is in the left column adsorption state (that is, the left adsorption column is performing adsorption work and the right adsorption column is performing regeneration work), the first connector is connected to the second connector, the fifth connector is connected to the sixth connector, the third connector is connected to the fourth connector, and the seventh connector is connected to the eighth connector. The flow path of the plasma is the first connector, the second connector, the left adsorption column, the sixth connector, the fifth connector, and the vein, and the flow path of the flushing fluid is the fourth connector, the third connector, the right adsorption column, the seventh connector, the eighth connector, and the waste liquid. bag; after that, by rotating the squeezing rods in the first rolling valve and the second rolling valve, the first connector is connected to the third connector, the fifth connector is connected to the seventh connector, the second connector is connected to the fourth connector, and the sixth connector is connected to the eighth connector. In this way, the immunoadsorption device changes from the original left column adsorption state to the right column adsorption state (that is, the right adsorption column performs adsorption work and the left adsorption column performs regeneration work). At this time, the flow path of the flushing liquid is the fourth connector, the second connector, the left adsorption column, the sixth connector, the eighth connector and the waste liquid bag, and the flow path of the plasma is the first connector, the third connector, the right adsorption column, the seventh connector, the fifth connector and the vein. It can be seen from this that when the present application switches between the left column adsorption state and the right column adsorption state of the immunoadsorption device, it is only necessary to rotate the squeezing rods in the first rolling valve and the second rolling valve. There is no need to control multiple tube clamps at the same time as in the traditional solution. This not only reduces the amount of operation for medical staff, but also reduces the error rate during operation of medical staff.

[0020] Regarding the immunoadsorption device provided in the third aspect of the present application, since the immunoadsorption device includes the switching device provided in the second aspect of the present application, the immunoadsorption device has all the advantages of the switching device provided in the second aspect of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] In order to more clearly illustrate the relevant technologies or the technical solutions in the embodiments of the present application, the following briefly introduces the drawings required for the description of the relevant technologies or the embodiments of the present application. Obviously, the drawings described below are only some embodiments of the present application, not all embodiments. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0022] Figure 1 A schematic structural diagram of a rolling valve provided in an embodiment of the present application;

[0023] Figure 2 A schematic diagram of the structure of a switching device provided in an embodiment of the present application;

[0024] Figure 3 This is a schematic diagram of the structure of the immunoadsorption device provided in the embodiments of the present application.

[0025] The symbols in the above drawings represent:

[0026] 100-roller valve, 110-annular hose, 120-connector, 130-extrusion rod, 121-first connector, 122-second connector, 123-third connector, 124-fourth connector, 125-fifth connector, 126-sixth connector, 127-seventh connector, 128-eighth connector, 200-switching device, 210-first roller valve, 220-second roller valve, 300-immunoadsorption device, 310 -Plasma separation device, 320-flushing device, 330-waste liquid bag, 340-left adsorption column, 350-right adsorption column, 311-first blood pump, 312-plasma separator, 313-arterial pot, 314-venous pot, 315-second blood pump, 321-elution bag, 322-balancing bag, 323-pre-flushing bag, 324-elution switch, 325-balancing switch, 326-pre-flushing switch, 327-third blood pump. DETAILED DESCRIPTION

[0027] In the related art, two adsorption columns are provided in the immunoadsorption system, and a number of pipes are connected between the two adsorption columns. These pipes are provided with multiple tube clamps. The switching between the two adsorption columns is achieved by controlling the multiple tube clamps, so that the immunoadsorption system is always in a working state of "one adsorption column adsorbs pathogenic substances and the other adsorption column regenerates". Although this can reduce the treatment time of patients, each switch requires the simultaneous control of multiple tube clamps. The medical staff has a large amount of operation and is prone to errors. At the very least, it will affect the patient's treatment process, and at worst, it will endanger the patient's life. Therefore, the present application proposes a roller valve, a switching device and an immunoadsorption device in the embodiments below. Blood purification by the immunoadsorption device can avoid the above-mentioned disadvantages in the related art.

[0028] In order to make the purpose, technical solutions and advantages of the present application more obvious and easy to understand, the present application will be clearly and completely described below in conjunction with the embodiments of the present application and the corresponding drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements with the same or similar functions. It should be understood that the embodiments of the present application described below are only used to explain the present application and are not used to limit the present application, that is, based on the various embodiments of the present application, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of this application. In addition, the technical features involved in the various embodiments of the present application described below can be combined with each other as long as they do not conflict with each other.

[0029] See also Figure 1 , Figure 1 is a schematic diagram of the structure of a roller valve. This embodiment provides a roller valve 100, which includes an annular hose 110, an extrusion rod 130, multiple connectors 120, and a hollow housing (not shown). The outer wall of the annular hose 110 includes a proximal outer wall located on one side of the annular center of the annular hose 110 and an opposite distal outer wall. The inner wall of the annular hose 110 includes a proximal inner wall located on one side of the annular center and an opposite distal inner wall. In other words, the proximal outer wall and the proximal inner wall are both close to the annular center, while the distal outer wall and the distal inner wall are both away from the annular center. In this embodiment, the annular hose 110 can be made of any material commonly used in the art that exhibits good elasticity and resilience, such as natural rubber, nitrile rubber, silicone rubber, polyethylene (PE), polyvinyl chloride (PVC), and thermoplastic elastomer (TPE). The specific material can be selected based on actual needs and is not limited in this application. It should be noted that the annular hose 110 is preferably annular in shape, with the annular center being the center of the annular ring.

[0030] Specifically, the extrusion rod 130, the annular hose 110 and the plurality of joints 120 are all located in the shell. The plurality of joints 120 are arranged on the distal outer wall of the annular hose 110 at intervals around the annular center. Each joint 120 is connected to the annular hose 110. The annular hose 110 is arranged on the inner bottom wall of the shell and its distal outer wall abuts against the inner side wall of the shell. One end of each joint 120 away from the annular hose 110 passes through the shell and is used to connect to an external pipe (not shown in the figure). A rotating shaft (not shown in the figure) is provided on the inner bottom wall of the shell and is located at the annular hose 110. 0, a squeezing rod 130 is disposed on the rotating shaft and rotatably engages with the rotating shaft. The opposite ends of the squeezing rod 130 abut the proximal outer wall of the annular hose 110 and squeeze the proximal outer wall toward the inner wall of the housing, causing the proximal inner wall of the annular hose 110, where squeezed by the squeezing rod 130, to mate with the distal inner wall. The internal space of the annular hose 110 is now divided into two subspaces by the squeezing rod 130. All connectors 120 connected to the same subspace are interconnected, while connectors 120 connected to different subspaces are unable to communicate with each other. Preferably, the middle portion of the squeezing rod 130 is disposed on the rotating shaft.

[0031] In actual use, the squeeze rod 130 can rotate about the axis under the action of an external force, thereby adjusting the connector 120 connected to each subspace and changing the flow direction of the liquid entering the annular hose 110 through the pipeline. In other words, when the flow direction of the liquid entering the annular hose 110 through the pipeline needs to be adjusted, the user can manipulate the squeeze rod 130 to rotate it about the axis. Since the annular hose 110 is fixed, the position on the annular hose 110 squeezed by the squeeze rod 130 will change during the rotation process. This will cause the connector 120 connected to each subspace to change, and the flow direction of the liquid entering the annular hose 110 through the pipeline will naturally change accordingly. For example, assuming that the roller valve 100 includes four connectors 120, represented by a, b, x, and y, respectively, and that a and b are connected to one subspace, and x and y are connected to another subspace, then liquid entering the annular hose 110 through a will flow out through b, and liquid entering the annular hose 110 through y will flow out through x. If the squeeze rod 130 is subsequently rotated so that a and x are connected to one subspace, and b and y are connected to another subspace, then liquid entering the annular hose 110 through a will no longer flow out through b but will flow out through x, and liquid entering the annular hose 110 through y will no longer flow out through x but will flow out through b, thereby achieving regulation of the flow direction of the liquid in the annular hose 110. It should be noted that the external force in this application comes from the user, that is, the user applies force to the squeeze rod 130, causing the squeeze rod 130 to rotate about the rotation axis.

[0032] It is understandable that the roller valve 100 of this embodiment can be used in an immunoadsorption system including two adsorption columns. Specifically, at least one roller valve 100 can be set in a pipe network connecting the two adsorption columns, and the multiple connectors 120 of the roller valve 100 can be connected to several pipes in the pipe network respectively. In this way, the flow direction of the plasma / flushing fluid entering the roller valve 100 can be adjusted by rotating the squeezing rod 130 in the roller valve 100, thereby achieving switching between the two adsorption columns for adsorption work (i.e., adsorption of pathogenic substances in the plasma), so that one adsorption column is performing adsorption work while the other adsorption column is performing regeneration work (i.e., flushing the adsorption column with flushing fluid). This switching in this embodiment only requires rotating the squeezing rod 130 in the roller valve 100, and there is no need to control multiple tube clamps at the same time as in traditional solutions. This not only reduces the amount of operation required by medical staff, but also reduces the error rate during medical staff's operation, thereby ensuring the smooth progress of blood purification.

[0033] In some embodiments, an operating window (not shown) communicating with the interior is provided on the outer wall of the housing, and the operating window corresponds to the squeezing rod 130. It is understood that the squeezing rod 130 is disposed within the housing. Therefore, to facilitate user manipulation of the squeezing rod 130 to rotate it about its axis, an operating window corresponding to the squeezing rod 130 can be provided on the outer wall of the housing. When the flow direction of the liquid within the annular hose 110 needs to be adjusted (i.e., the squeezing rod 130 needs to be rotated about its axis), the user can insert a finger (such as an index finger and thumb) into the housing through the operating window, grasp the squeezing rod 130, and apply a force to rotate the squeezing rod 130. This causes the squeezing rod 130 to rotate about its axis, changing the position on the annular hose 110 squeezed by the squeezing rod 130. This, in turn, causes the connector 120 communicating with each subspace to change, and thus, the flow direction of the liquid entering the annular hose 110 through the pipeline will naturally change accordingly, thereby achieving adjustment of the flow direction of the liquid within the annular hose 110.

[0034] In other embodiments, a through hole (not shown) communicating with the interior of the shell is opened on the outer wall of the shell, and the through hole corresponds to the extrusion rod 130; in addition to the structure given above, the rolling valve 100 also includes a knob (not shown) and a connecting rod (not shown), the knob is arranged on one end of the connecting rod, and the other end of the connecting rod enters the shell through the hole and is arranged on the extrusion rod 130. It can be understood that the squeezing rod 130 is arranged in the shell. In order to facilitate the user to manipulate the squeezing rod 130 to rotate it around the rotation axis, a knob can be set on one end of the connecting rod, and the other end of the connecting rod is inserted into the shell and connected to the squeezing rod 130. When the flow direction of the liquid in the annular hose 110 needs to be adjusted (that is, the squeezing rod 130 needs to be rotated around the rotation axis), the user can hold the knob and apply force to the knob to rotate it. In this way, the knob will drive the squeezing rod 130 to rotate around the rotation axis through the connecting rod, and the position on the annular hose 110 squeezed by the squeezing rod 130 will change, which will cause the joint 120 connected to each subspace to change. Then the flow direction of the liquid entering the annular hose 110 through the pipeline will naturally change accordingly, thereby realizing the adjustment of the liquid flow direction in the annular hose 110.

[0035] In one or more embodiments, the knob includes a base (not shown), one side of the base being connected to the connecting rod and the other side of the base having a grip (not shown). The grip's length aligns with the axis of the squeeze rod 130. It is understood that the portion of the knob intended for the user to grip is actually the grip. That is, when the flow direction of the liquid within the annular hose 110 needs to be adjusted (i.e., when the squeeze rod 130 needs to be rotated about its axis), the user grips the grip on the base and applies a force to the grip to rotate the base. In addition, it should be noted that the extrusion rod 130 divides the internal space of the annular hose 110 into two subspaces, and the two subspaces are respectively located on both sides of the extrusion rod 130. Therefore, when the length direction of the hand-held portion is consistent with the axial direction of the extrusion rod 130, the two subspaces are actually also respectively located on both sides of the hand-held portion. Although the user cannot clearly observe the extrusion rod 130 located in the shell, the user can clearly understand the orientation of the extrusion rod 130 in the shell by observing the hand-held portion, and then analyze the positions of the two subspaces. In this way, it is more convenient for the user to control the rotation of the extrusion rod 130, and it is also more convenient for the user to adjust the flow direction of the liquid in the annular hose 110.

[0036] In one or more embodiments, the housing is provided with a plurality of marking points (not shown) spaced around the knob. The marking points at different locations on the housing correspond to different valve states of the roller valve 100. In different valve states, the connectors 120 communicating with each subspace are different, meaning that the flow direction of the liquid within the annular hose 110 is different in different valve states. Specifically, the marking points indicate to the user the current valve state of the roller valve 100 when the end of the handheld portion is aligned with the handheld portion. That is, to adjust the flow direction of the liquid within the annular hose 110 to a target flow direction (corresponding to a target valve state), the user rotates the extrusion rod 130 about the rotation axis using the knob. When the end of the handheld portion rotated into the knob aligns with the target marking point (corresponding to the target valve state), the roller valve 100 is in the target valve state, and the flow direction of the liquid within the annular hose 110 is the target flow direction. Here, we still use the example given above, assuming that the rolling valve 100 includes four joints 120, a, b, x, and y, and the valve state of the rolling valve 100 includes valve state A and valve state B. The marking points include a first marking point corresponding to valve state A and a second marking point corresponding to valve state B. At the current moment, the end of the handheld portion of the knob is aligned with the first marking, and the rolling valve 100 is in valve state A. In valve state A, a and b are connected to one subspace, and x and y are connected to another subspace. Then, the annular soft The liquid in tube 110 will flow out through b, and the liquid entering the annular hose 110 through y will flow out through x; if the knob is subsequently turned so that the end of the handheld part is aligned with the second marker, the roller valve 100 will change from the original valve state A to the valve state B. In valve state B, a and x are connected to one subspace, and b and y are connected to another subspace. Then, the liquid entering the annular hose 110 through a will no longer flow out through b, but will flow out through x, and the liquid entering the annular hose 110 through y will no longer flow out through x, but will flow out through b.

[0037] In some embodiments, in addition to the structure given above, the rolling valve 100 also includes a support and guide structure (not shown in the figure), which is connected between the extrusion rod 130 and the inner bottom wall of the shell, and is used to support and guide the extrusion rod 130 during the rotation of the extrusion rod 130 around the rotating axis, thereby ensuring the stability of the extrusion rod 130 during the rotation process.

[0038] In one or more embodiments, the support and guide structure includes two rollers (not shown). Both rollers are rotatably mounted on the squeeze rod 130, located on opposite sides of a rotation axis, and each roller contacts the inner bottom wall of the housing. Specifically, the rollers are configured to roll on the inner bottom wall of the housing when the squeeze rod 130 rotates about the rotation axis. In other words, when the flow direction of the liquid in the annular hose 110 needs to be adjusted, the user can manipulate the squeeze rod 130 to rotate it about the rotation axis. Because the rollers are rotatably mounted on the squeeze rod 130 and contact the inner bottom wall of the housing, each roller rolls on the inner bottom wall of the housing during the squeeze rod 130's rotation, thereby supporting and guiding the rotating squeeze rod 130 through the rolling of each roller.

[0039] It should be noted that the number of rollers is not limited to two. In other embodiments, the number of rollers may be one, three, or more. The specific number of rollers may be determined based on actual needs and is not a limitation of this invention. For example, when multiple rollers are provided, the multiple rollers are rotatably mounted on the extrusion rod 130 and spaced apart along the axis of the extrusion rod 130. It should also be noted that, based on the foregoing description, the extrusion rod 130 rotates by being rotatably mounted on a rotating shaft. However, the rotating shaft can be omitted. In other words, the extrusion rod 130 can be directly mounted on the inner side of the annular hose 110, and the opposite ends of the extrusion rod 130 can squeeze the annular hose 110. In this case, the extrusion rod 130 can be confined to the inner side of the annular hose 110 by the inner bottom wall and the inner top wall of the housing, and the rotation of the extrusion rod 130 can be supported and guided by the multiple rollers rotatably mounted on the extrusion rod 130. In this manner, the stability of the extrusion rod 130 during rotation can also be ensured.

[0040] In one or more embodiments, the support and guide structure includes an annular chute (not shown) formed on the inner bottom wall of the housing and surrounding the rotation axis. Two sliders (not shown) are slidably disposed within the chute. Both sliders are connected to the extrusion rod 130 and located on either side of the rotation axis. Specifically, the sliders are configured to slide within the chute as the extrusion rod 130 rotates about the rotation axis. In other words, to adjust the flow direction of the liquid within the annular hose 110, the user can manipulate the extrusion rod 130 to rotate it about the rotation axis. Since the sliders are connected to the extrusion rod 130 and slide in engagement with the chute, each slider slides within the chute during the rotation of the extrusion rod 130, thereby supporting and guiding the rotating extrusion rod 130 through the sliding motion of each slider. In addition, it should be noted that the number of annular slides is not limited to one. In other embodiments, the annular slides may also include two or more, which can be set specifically according to actual needs. This application does not make a sole limitation on this. For example, when the annular slides include multiple, the multiple annular slides are radially arranged around the rotating shaft, and the rotation axis points to the direction of the proximal outer wall. Any two adjacent annular slides are separated, and each annular slide is provided with two sliders (located on both sides of the rotating shaft respectively), and all sliders are connected to the extrusion rod 130.

[0041] In some embodiments, the extrusion rod 130 has two opposite ends each with an inwardly recessed insertion hole (not shown) extending along the axis of the extrusion rod 130. In addition to the aforementioned structure, the roller valve 100 further includes two insertion rods (not shown) and two return springs (not shown). The two return springs are disposed in the two insertion holes, and the two insertion rods are inserted in the two insertion holes. Each return spring has two ends connected to the extrusion rod 130 and the corresponding insertion rod, respectively. Specifically, the return springs are configured to be compressed when the opposite ends of the extrusion rod 130 abut against the proximal outer wall of the annular hose 110. The insertion rods are configured to compress the proximal outer wall of the annular hose 110 under the elastic force of the return springs when the opposite ends of the extrusion rod 130 abut against the proximal outer wall of the annular hose 110. That is to say, when the opposite ends of the squeezing rod 130 abut against the proximal outer wall of the annular hose 110, not only the end of the squeezing rod 130 squeezes the annular hose 110, but the insertion rod also squeezes the annular hose 110 under the elastic force of the return spring. In this way, the effect of the squeezing rod 130 on separating the internal space of the annular hose 110 can be improved, and the liquid in one subspace can be effectively prevented from penetrating into the other subspace through the position squeezed by the squeezing rod 130 in the annular hose 110, that is, the mutual penetration of liquid between the two subspaces can be prevented.

[0042] See also Figure 2 and Figure 3 , Figure 2 is a structural diagram of the switching device. Figure 3This is a schematic diagram of the structure of an immunoadsorption device. This embodiment provides a switching device 200 for use in an immunoadsorption device 300. The immunoadsorption device 300 includes a plasma separation device 310, a flushing device 320, a left adsorption column 340, a right adsorption column 350, and a waste liquid bag 330. The plasma separation device 310 is connected to a patient's artery and vein at both ends, and is used to draw blood from the artery and separate plasma. The flushing device 320 is used to provide flushing fluid. Specifically, the switching device 200 includes a first rolling valve 210 and a second rolling valve 220. The first rolling valve 210 and the second rolling valve 220 are both the rolling valve 100 described above. The connector 120 in the first rolling valve 210 includes a first connector 121, a second connector 122, a third connector 123 and a fourth connector 124. The connector 120 in the second rolling valve 220 includes a fifth connector 125, a sixth connector 126, a seventh connector 127 and an eighth connector 128. The two ends of the left adsorption column 340 are respectively connected to the second connector 122 and the sixth connector 126. The plasma separation device 310 is connected to the first connector 121. The fifth connector 125 is used to connect to the vein. The two ends of the right adsorption column 350 are respectively connected to the third connector 123 and the seventh connector 127. The flushing device 320 is connected to the fourth connector 124. The waste liquid bag 330 is connected to the eighth connector 128.

[0043] In this embodiment, the immunoadsorption device 300 has two working states, namely the left column adsorption state and the right column adsorption state. In the left column adsorption state, the left adsorption column 340 performs adsorption work and the right adsorption column 350 performs regeneration work. The flow path of the plasma is the plasma separation device 310, the first connector 121, the second connector 122, the left adsorption column 340, the sixth connector 126, the fifth connector 125 and the vein. The flow path of the flushing liquid is the flushing device 320, the fourth connector 124, the third connector 123, the right adsorption column 350, the seventh connector 126 and the vein. Connector 127, the eighth connector 128 and the waste liquid bag 330; in the right column adsorption state, the right adsorption column 350 performs adsorption work and the left adsorption column 340 performs regeneration work, the flow path of the plasma is the plasma separation device 310, the first connector 121, the third connector 123, the right adsorption column 350, the seventh connector 127, the fifth connector 125 and the vein, and the flow path of the flushing liquid is the flushing device 320, the fourth connector 124, the second connector 122, the left adsorption column 340, the sixth connector 126, the eighth connector 128 and the waste liquid bag 330.

[0044] In actual applications, the switching device 200 is used to adjust the operating state of the immunoadsorption device 300 by rotating the extrusion rods 130 in the first and second roller valves 210, 220. Specifically, when the operating state of the immunoadsorption device 300 needs to be adjusted, the extrusion rods 130 in the first and second roller valves 210, 220 can be rotated to adjust the flow direction of the liquid in the first and second roller valves 210, 220. This, in turn, adjusts the valve states of the first and second roller valves 210, 220, and thus the operating state of the immunoadsorption device 300. Specifically, the valve state of the rolling valve 100 includes a first valve state and a second valve state. When the first rolling valve 210 and the second rolling valve 220 are both in the first valve state, the first joint 121 is connected to the second joint 122, the fifth joint 125 is connected to the sixth joint 126, the third joint 123 is connected to the fourth joint 124, and the seventh joint 127 is connected to the eighth joint 128, and the immunoadsorption device 300 is in the left column adsorption state; thereafter, the squeezing rod 130 in the first rolling valve 210 and the second rolling valve 220 can be rotated so that the first rolling valve 210 and the second rolling valve 220 are both in the second valve state, that is, the first joint 121 is connected to the third joint 123, the fifth joint 125 is connected to the seventh joint 127, the second joint 122 is connected to the fourth joint 124, and the sixth joint 126 is connected to the eighth joint 128. At this time, the working state of the immunoadsorption device 300 changes from the original left column adsorption state to the right column adsorption state, and the working state adjustment of the immunoadsorption device 300 is realized.

[0045] As can be seen from the above, in this embodiment, when switching between the left column adsorption state and the right column adsorption state of the immunoadsorption device 300, it is only necessary to rotate the squeezing rod 130 in the first rolling valve 210 and the second rolling valve 220. There is no need to control multiple tube clamps at the same time as in traditional solutions. This not only reduces the amount of operation required by medical staff, but also reduces the error rate during operation.

[0046] See also Figure 3 This embodiment provides an immunoadsorption device 300, including a plasma separation device 310, a flushing device 320, a left adsorption column 340, a right adsorption column 350, a waste liquid bag 330 and the switching device 200 described above. As for the process of using the switching device 200 to switch the working state of the immunoadsorption device 300 (i.e., the left column adsorption state and the right column adsorption state), please refer to the relevant description of the switching device 200 in the above text, and this application will not elaborate on it here.

[0047] In some embodiments, see Figure 3The plasma separator 310 includes a first blood pump 311, a second blood pump 315, and a plasma separator 312. One end of the plasma separator 312 is connected to the first blood pump 311. The first blood pump 311 is used to connect to the patient's artery, and the other end of the plasma separator 312 is used to connect to the patient's vein. The plasma separator 312 is also connected to the first connector 121 via the second blood pump 315. Specifically, the first blood pump 311 is used to draw blood from the artery and pump it to the plasma separator 312; the plasma separator 312 is used to separate plasma from the blood; and the second blood pump 315 is used to draw plasma from the plasma separator 312 and pump it to the first connector 121. In other words, in actual use, the first blood pump 311 can draw blood from the patient's artery and pump the drawn blood to the plasma separator 312. The plasma separator 312 can separate plasma from the blood, and the second blood pump 315 can draw plasma from the plasma separator 312 and pump the drawn plasma to the first connector 121.

[0048] As one or more embodiments thereof, the plasma separator 310 includes, in addition to the structure given above, an arterial pot 313 and a venous pot 314. One end of the plasma separator 312 is connected to the first blood pump 311 through the arterial pot 313, and the other end is used to be connected to the vein through the venous pot 314. The venous pot 314 is also connected to the fifth connector 125. It can be understood that the arterial pot 313 can filter larger particulate matter to prevent these substances from entering the plasma separator 312 and causing blockage or damage to the plasma separator 312; the arterial pot 313 can also play a certain buffering role, allowing blood to enter the plasma separator 312 at a relatively stable flow rate, avoiding the adverse effects of sudden changes in blood flow rate on the entire treatment process; the arterial pot 313 can be provided with a monitoring port, which can be connected to a pressure monitoring device (such as Figure 3 The blood pressure at the blood outlet is monitored in real time using the Pa in the blood flow meter. This helps medical staff to promptly understand the state of blood flow and determine whether there are problems such as pipeline blockage and abnormal pressure. In addition, when a blood test is required, blood samples can be conveniently collected from the arterial bottle 313 without having to be drawn directly from the patient's blood vessels, reducing the patient's pain and infection risk.

[0049] An important function of the intravenous pot 314 is to prevent air from entering the human blood circulation system. The intravenous pot 314 is usually designed with a certain capacity and a special structure to capture and accumulate tiny bubbles that may be mixed into the blood, thereby avoiding the occurrence of serious complications such as air embolism. Similar to the arterial pot 313, the intravenous pot 314 can also be provided with a monitoring port, which can be connected to a pressure monitoring device (such as Figure 3Pb in) to monitor the pressure at the blood return end. Once an abnormal pressure is detected, an alarm can be issued to remind medical staff to take timely measures. The intravenous pot 314 can be equipped with a bubble detector and a liquid level monitoring device. The bubble detector can sensitively detect tiny bubbles and trigger an alarm to ensure the safety of blood return. The liquid level monitoring device can monitor the liquid level of the blood in the intravenous pot 314 to prevent excessive filling or emptying of blood. The intravenous pot 314 is usually provided with a drug addition port. When it is necessary to add drugs to the blood before returning it to the human body, the drug can be conveniently injected through the drug addition port to ensure that the drug and blood are fully mixed before being returned to the patient's body.

[0050] In some embodiments, see Figure 3 The flushing device 320 includes an elution bag 321, a balancing bag 322, and a priming bag 323. The elution bag 321, the balancing bag 322, and the priming bag 323 are respectively connected to the fourth connector 124. Specifically, the flushing liquid includes an eluent, a balancing liquid, and a priming liquid. The elution bag 321 is used to store the eluent, the balancing bag 322 is used to store the balancing liquid, and the priming bag 323 is used to store the priming liquid. In addition, it should be noted that the eluent can be any solution with an elution function commonly used in the art, such as sodium chloride solution, urea, guanidine hydrochloride solution, etc., which can be selected according to actual needs, and this application does not make a sole limitation on this; the balancing solution can also be any solution with a balancing function commonly used in the art, such as phosphate buffer, Tris-HCl buffer, buffer containing bovine serum albumin (BSA), etc., which can be selected according to actual needs, and this application does not make a sole limitation on this; the pre-flush solution can also be any solution with a flushing function commonly used in the art, such as physiological saline (0.9% sodium chloride solution), etc., which can be selected according to actual needs, and this application does not make a sole limitation on this.

[0051] It can be understood that the eluent is mainly used to elute the pathogenic substances adsorbed in the adsorption column, so that the adsorption capacity of the adsorption column can be restored; during the use of the adsorption column, the pathogenic substances will be adsorbed on the adsorbent. Over time, the adsorption capacity of the adsorption column will gradually decrease. By using a specific eluent, the interaction between the pathogenic substances and the adsorbent can be destroyed, thereby eluting the pathogenic substances from the adsorption column; different types of adsorption columns may require different eluents, and the selection usually depends on the type of adsorption column, the adsorbed pathogenic substances and the regeneration requirements.

[0052] The function of the balancing solution is to restore the adsorption column to its initial equilibrium state after elution. After the elution process, the internal environment of the adsorption column may have changed, such as pH value, ionic strength, etc. The balancing solution can adjust these parameters to stabilize the performance of the adsorption column and prepare for the next adsorption. The composition of the balancing solution is usually similar to the buffer solution used in the adsorption process, which can ensure the consistency of the adsorption column during the adsorption and regeneration process. At the same time, the balancing solution can also remove the residual eluent and other impurities in the adsorption column, thereby ensuring the cleanliness of the adsorption column.

[0053] The priming liquid can flush out residual substances in the adsorption column (such as blood, protein, drugs, etc. that may remain after the last use), which helps to reduce the impact of impurities on the regeneration of the adsorption column and improve the regeneration effect of the adsorption column; the priming liquid can expel the air in the adsorption column to ensure that the priming liquid can fully flow through all parts of the adsorption column during the regeneration of the adsorption column, and avoid the occurrence of bubbles that affect the adsorption performance of the adsorption column; during the priming process, you can check whether the connection between the adsorption column and the pipeline is tight and whether there is any leakage to ensure the safety of the adsorption column during regeneration; the priming liquid can make the adsorbent of the adsorption column fully moist, thereby preparing for subsequent regeneration; at the same time, the priming liquid can also adjust parameters such as the temperature and pressure of the adsorption column to make it better adapt to the regeneration of the adsorption column.

[0054] As one or more embodiments thereof, the flushing device 320, in addition to the structure given above, also includes a third blood pump 327, an elution switch 324, a balance switch 325 and a pre-flushing switch 326. The elution bag 321 is connected to the third blood pump 327 through the elution switch 324, the balance bag 322 is connected to the third blood pump 327 through the balance switch 325, the pre-flushing bag 323 is connected to the third blood pump 327 through the pre-flushing switch 326, and the third blood pump 327 is connected to the fourth connector 124. Specifically, the elution switch 324 is used to connect the third blood pump 327 and the elution bag 321 when it is turned on, or to block the third blood pump 327 and the elution bag 321 when it is turned off; the balance switch 325 is used to connect the third blood pump 327 and the balance bag 322 when it is turned on, or to block the third blood pump 327 and the balance bag 322 when it is turned off; the priming switch 326 is used to connect the third blood pump 327 and the priming bag 323 when it is turned on, or to block the third blood pump 327 and the priming bag 323 when it is turned off; the third blood pump 327 is used to draw eluent from the elution bag 321 and pump it to the fourth connector 124 when the elution switch 324 is turned on, or to draw balancing liquid from the balance bag 322 and pump it to the fourth connector 124 when the balance switch 325 is turned on, or to draw priming liquid from the priming bag 323 and pump it to the fourth connector 124 when the priming switch 326 is turned on.

[0055] That is to say, the connection and disconnection between the third blood pump 327 and the elution bag 321 is controlled by turning the elution switch 324 on / off. Only when the elution switch 324 is on can the third blood pump 327 pump the eluent in the elution bag 321 to the fourth connector 124; the connection and disconnection between the third blood pump 327 and the balancing bag 322 is controlled by turning the balancing switch 325 on / off. Only when the balancing switch 325 is on can the third blood pump 327 pump the balancing liquid in the balancing bag 322 to the fourth connector 124; the connection and disconnection between the third blood pump 327 and the priming bag 323 is controlled by turning the priming switch 326 on / off. Only when the priming switch 326 is on can the third blood pump 327 pump the priming liquid in the priming bag 323 to the fourth connector 124.

[0056] To facilitate those skilled in the art to clearly understand the working process of the immunoadsorption device 300, an example of switching from the left column adsorption state to the right column adsorption state is given below:

[0057] When the immunosorbent device 300 is in the left column adsorption state, the first roller valve 210 and the second roller valve 220 are both in the first valve state (i.e., the first connector 121 is connected to the second connector 122, the fifth connector 125 is connected to the sixth connector 126, the third connector 123 is connected to the fourth connector 124, and the seventh connector 127 is connected to the eighth connector 128). If the immunosorbent device 300 is to be switched to the right column adsorption state, the valve state of the first roller valve 210 can be switched from the first valve state to the second valve state (i.e., the first connector 121 is connected to the third connector 123, and the second connector 122 is connected to the fourth connector 124). At this time, the plasma flow path is the plasma separator 312, the first connector 121, the third connector 123, the right adsorption column 350, the seventh connector 127, the eighth connector 128, and the waste liquid bag 330.

[0058] After 2 minutes, the valve state of the second roller valve 220 can be switched from the first valve state to the second valve state (i.e., the fifth connector 125 is connected to the seventh connector 127, and the sixth connector 126 is connected to the eighth connector 128). At this time, the flow path of the plasma is the plasma separator 312, the first connector 121, the third connector 123, the right adsorption column 350, the seventh connector 127, the fifth connector 125, and the vein. The right adsorption column 350 adsorbs the pathogenic substances in the plasma, and the adsorbed plasma is returned to the patient's vein.

[0059] After 2 minutes, the elution switch 324 can be turned on, and the balance switch 325 and the pre-flushing switch 326 can be turned off. The eluent flows through the elution bag 321, the fourth connector 124, the second connector 122, the left adsorption column 340, the sixth connector 126, the eighth connector 128, and the waste liquid bag 330, and the left adsorption column 340 begins to be eluted with the eluent.

[0060] After 6 minutes, the balancing switch 325 can be turned on, and the elution switch 324 and the pre-flushing switch 326 can be turned off. The balancing liquid flows through the balancing bag 322, the fourth connector 124, the second connector 122, the left adsorption column 340, the sixth connector 126, the eighth connector 128, and the waste liquid bag 330, and the left adsorption column 340 begins to be equilibrated with the balancing liquid.

[0061] After 6 minutes, the priming switch 326 can be turned on, and the balance switch 325 and the elution switch 324 can be turned off. The priming liquid flows through the priming bag 323, the fourth connector 124, the second connector 122, the left adsorption column 340, the sixth connector 126, the eighth connector 128, and the waste liquid bag 330, and the left adsorption column 340 begins to be flushed with the priming liquid.

[0062] After 3 minutes, the regeneration of the left adsorption column 340 is completed, the pre-flushing switch 326 is closed, and then the valve state of the first rolling valve 210 is switched from the second valve state to the first valve state (that is, the first connector 121 is connected to the second connector 122, and the third connector 123 is connected to the fourth connector 124). At this time, the flow path of the plasma is the plasma separator 312, the first connector 121, the second connector 122, the left adsorption column 340, the sixth connector 126, the eighth connector 128 and the waste liquid bag 330, and the next cycle begins.

[0063] The above embodiments are only preferred implementations of the present application. They are not the only limitations on the rolling valve 100, the switching device 200 and the immunoadsorption device 300. In this regard, those skilled in the art can flexibly set them according to the actual application scenarios based on the above embodiments. It can be understood that through the implementation of the above embodiments of the present application, the rolling valve 100 is composed of a hollow shell and an annular hose 110, an extrusion rod 130 and a plurality of connectors 120 located in the shell. The plurality of connectors 120 are arranged on the distal outer wall of the annular hose 110 at intervals around the annular center. Each connector 120 is connected to the annular hose 110. The annular hose 110 is arranged on the inner bottom wall of the shell and its distal outer wall is in contact with the inner side wall of the shell. The end of each connector 120 away from the annular hose 110 passes through the shell and is used to connect to an external pipe. The inner bottom wall of the shell is provided with The rotating shaft is located inside the annular hose 110. The extrusion rod 130 is disposed on the rotating shaft and rotates with the rotating shaft. The opposite ends of the extrusion rod 130 abut the proximal outer wall of the annular hose 110 and squeeze the proximal outer wall toward the inner wall of the housing, so that the proximal inner wall of the annular hose 110 at the location squeezed by the extrusion rod 130 is aligned with the distal inner wall. At this time, the internal space of the annular hose 110 is divided into two subspaces by the extrusion rod 130. All connectors 120 connected to the same subspace are interconnected, while connectors 120 connected to different subspaces are not interconnected. In actual application, the extrusion rod 130 can be rotated about the rotating shaft. Since the annular hose 110 is fixed, the location on the annular hose 110 squeezed by the extrusion rod 130 will change during the rotation of the extrusion rod 130. This causes the connector 120 connected to each subspace to change, and the flow direction of the liquid entering the annular hose 110 through the pipeline will naturally change accordingly. On this basis, at least one roller valve 100 can be applied to an immunoadsorption system including two adsorption columns. Specifically, at least one roller valve 100 can be set in a pipe network connecting the two adsorption columns, and multiple connectors 120 of the roller valve 100 are respectively connected to several pipes in the pipe network. In this way, the flow direction of the plasma / washing fluid entering the roller valve 100 can be adjusted by rotating the squeezing rod 130 in the roller valve 100, thereby realizing switching between the two adsorption columns for adsorption work, so that one adsorption column is performing adsorption work while the other adsorption column is performing regeneration work. This switching only requires rotating the squeezing rod 130 in the rolling valve 100, and there is no need to control multiple tube clamps at the same time as in traditional solutions. This not only reduces the amount of operation for medical staff, but also reduces the error rate during operation. In addition, during the entire process of blood purification, there is no need to adjust the operating speeds of the first blood pump 311, the second blood pump 315, the third blood pump 327, etc., and the adsorption work of the adsorption column does not require any operation. It is only necessary to control the regeneration process of the adsorption column, and the adsorption column can be regenerated in just 20 minutes. The simultaneous use of two adsorption columns can greatly shorten the treatment process.

[0064] It should be noted that the present application is described in a progressive manner in the several embodiments shown above, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the various embodiments can be referred to each other. It should also be noted that in the text description of the present application, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply that there is such an actual relationship or order between these entities or operations. Further, the terms "include", "comprise" or any other corresponding variants are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only these elements, but also other elements not explicitly listed, or elements inherent to such a process, method, article or device; and, in the absence of further restrictions, the elements defined by the sentence "including one..." do not exclude the presence of other identical elements in the process, method, article or device including the elements.

[0065] Furthermore, by implementing the several embodiments described above, those skilled in the art can implement or use the present application. Various modifications to the several embodiments described above will be readily apparent to those skilled in the art, and the general principles defined herein can be implemented in other embodiments not shown without departing from the spirit or scope of the present application. Therefore, the present application is not limited to the several embodiments described above, but rather is intended to conform to the broadest scope consistent with the principles and novel features disclosed herein.

Claims

1. A rolling valve, characterized in that: The invention comprises an annular hose and a plurality of connectors, wherein the outer wall of the annular hose comprises a proximal outer wall located on one side of the annular center and an opposite distal outer wall, and the plurality of connectors are arranged on the distal outer wall at intervals around the annular center and are all connected to the annular hose; The rolling valve also includes an extrusion rod and a hollow shell, the extrusion rod, the annular hose and the plurality of connectors are all located in the shell, the annular hose is arranged on the inner bottom wall of the shell, and the distal outer wall abuts against the inner side wall of the shell, one end of each connector away from the annular hose passes through the shell and is used to connect to an external pipe, a rotating shaft is provided on the inner bottom wall of the shell, the extrusion rod is provided on the rotating shaft and rotatably cooperates with the rotating shaft, the opposite ends of the extrusion rod abut against the proximal outer wall and squeeze the proximal outer wall toward the inner side wall of the shell, so that the internal space of the annular hose is divided into two subspaces by the extrusion rod, and all the connectors connected to the same subspace are interconnected; The extrusion rod is used to rotate around the rotation axis under the action of external force to adjust the joints communicating with each of the subspaces and change the flow direction of the liquid entering the annular hose through the pipeline.

2. The rolling valve according to claim 1, characterized in that: An operating window communicating with the interior is provided on the outer wall of the shell, and the operating window corresponds to the extrusion rod.

3. The rolling valve according to claim 1, characterized in that: A through hole communicating with the interior is provided on the outer wall of the shell, and the through hole corresponds to the extrusion rod. The rolling valve also includes a knob and a connecting rod. The knob is arranged on one end of the connecting rod, and the other end of the connecting rod enters the shell through the through hole and is arranged on the extrusion rod.

4. The rolling valve according to claim 3, characterized in that: The knob comprises a base, one side of the base is connected to the connecting rod, and a hand-held portion is formed on the other opposite side. The length direction of the hand-held portion is consistent with the axial direction of the extrusion rod.

5. The rolling valve according to claim 4, characterized in that: A plurality of marking points are arranged on the shell at intervals around the knob, and the marking points at different positions on the shell correspond to different valve states of the rolling valve. The connectors connected to each subspace are different in different valve states, and the marking points are used to indicate to the user the current valve state of the rolling valve when the end of the handheld portion is aligned with itself.

6. The rolling valve according to claim 1, characterized in that: It also includes two rollers, both of which are rotatably arranged on the extrusion rod, and the two rollers are respectively located on both sides of the rotating shaft. Each of the rollers is in contact with the inner bottom wall of the shell, and the rollers are used to roll on the inner bottom wall of the shell when the extrusion rod rotates around the rotating shaft.

7. The roller valve according to claim 1, characterized in that: An annular groove surrounding the rotating shaft is provided on the inner bottom wall of the shell, and two sliders are slidably arranged in the annular groove. Both sliders are connected to the extrusion rod and are respectively located on both sides of the rotating shaft. The sliders are used to slide in the annular groove when the extrusion rod rotates around the rotating shaft.

8. The roller valve according to claim 1, characterized in that: The annular hose is in the shape of a circular ring.

9. A switching device, characterized in that: Applied to an immunoadsorption device, the immunoadsorption device includes a plasma separation device, a flushing device, a left adsorption column, a right adsorption column and a waste liquid bag, the two ends of the plasma separation device are respectively used to connect the patient's artery and vein, the switching device includes a first roller valve and a second roller valve, the first roller valve and the second roller valve are both roller valves according to any one of claims 1 to 8, the first roller valve has a first joint, a second joint, a third joint and a fourth joint, the second roller valve has a fifth joint, a sixth joint, a seventh joint and an eighth joint, the two ends of the left adsorption column are respectively connected to the second joint and the sixth joint, the plasma separation device is connected to the first joint, the fifth joint is used to connect to the vein, the two ends of the right adsorption column are respectively connected to the third joint and the seventh joint, the flushing device is connected to the fourth joint, and the waste liquid bag is connected to the eighth joint, wherein: The plasma separation device is used to draw blood from the artery and separate plasma; The flushing device is used to provide flushing liquid; The switching device is used to adjust the working state of the immunoadsorption device by rotating the squeezing rods in the first rolling valve and the second rolling valve; The working state includes a left column adsorption state, in which the first connector is connected to the second connector, the fifth connector is connected to the sixth connector, the third connector is connected to the fourth connector, and the seventh connector is connected to the eighth connector, the flow path of the plasma is the first connector, the second connector, the left adsorption column, the sixth connector, the fifth connector, and the vein, and the flow path of the flushing fluid is the fourth connector, the third connector, the right adsorption column, the seventh connector, the eighth connector, and the waste liquid bag; The working state also includes a right column adsorption state. In the right column adsorption state, the first connector is connected to the third connector, the fifth connector is connected to the seventh connector, the second connector is connected to the fourth connector, and the sixth connector is connected to the eighth connector. The flow path of the plasma is the first connector, the third connector, the right adsorption column, the seventh connector, the fifth connector and the vein, and the flow path of the flushing fluid is the fourth connector, the second connector, the left adsorption column, the sixth connector, the eighth connector and the waste liquid bag.

10. An immunoadsorption device, characterized in that: The device comprises a plasma separation device, a waste liquid bag, a flushing device, a left adsorption column, a right adsorption column, and the switching device according to claim 9, wherein the two ends of the plasma separation device are respectively used to connect to the patient's artery and vein, the first roller valve in the switching device has a first connector, a second connector, a third connector, and a fourth connector, the second roller valve in the switching device has a fifth connector, a sixth connector, a seventh connector, and an eighth connector, the two ends of the left adsorption column are respectively connected to the second connector and the sixth connector, the plasma separation device is connected to the first connector, the fifth connector is used to connect to the vein, the two ends of the right adsorption column are respectively connected to the third connector and the seventh connector, the flushing device is connected to the fourth connector, and the waste liquid bag is connected to the eighth connector, wherein: The plasma separation device is used to draw blood from the artery and separate plasma; The flushing device is used to provide flushing liquid; The switching device is used to adjust the working state of the immunoadsorption device by rotating the squeezing rods in the first rolling valve and the second rolling valve; The working state includes a left column adsorption state, in which the first connector is connected to the second connector, the fifth connector is connected to the sixth connector, the third connector is connected to the fourth connector, and the seventh connector is connected to the eighth connector, the flow path of the plasma is the first connector, the second connector, the left adsorption column, the sixth connector, the fifth connector, and the vein, and the flow path of the flushing fluid is the fourth connector, the third connector, the right adsorption column, the seventh connector, the eighth connector, and the waste liquid bag; The working state also includes a right column adsorption state. In the right column adsorption state, the first connector is connected to the third connector, the fifth connector is connected to the seventh connector, the second connector is connected to the fourth connector, and the sixth connector is connected to the eighth connector. The flow path of the plasma is the first connector, the third connector, the right adsorption column, the seventh connector, the fifth connector and the vein, and the flow path of the flushing fluid is the fourth connector, the second connector, the left adsorption column, the sixth connector, the eighth connector and the waste liquid bag.

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