Control method, device and system of electrolyte analyzer and storage medium

Abstract

The invention relates to the technical field of electrolyte analysis, solves the problem that the final detection precision is affected due to the fact that an electrode slope value obtained in the calibration process in the prior art is not completely matched with an electrode state during sample detection, and provides a control method, device and system of an electrolyte analyzer and a medium. The method comprises the following steps: in response to a startup instruction, controlling an electrolyte analyzer to perform self-inspection to obtain a self-inspection result; in response to the self-checking result meeting a preset self-checking condition, controlling the electrolyte analyzer to perform calibration according to a preset calibration rule to obtain a calibration result; controlling the electrolyte analyzer to detect the to-be-detected sample in response to the condition that the calibration result meets a preset calibration condition, so as to obtain an initial detection result; and correcting the initial detection result according to the calibration result to obtain a target detection result of the to-be-detected sample. According to the invention, measurement errors caused by unstable electrode performance or improper maintenance can be reduced, and the consistency and reliability of measurement are improved.

Description

Technical Field

[0001] The present invention relates to the technical field of electrolyte detection and analysis, and in particular to a control method, device, system and storage medium of an electrolyte analyzer. Background Art

[0002] An electrolyte analyzer is an analytical device used to measure the electrolyte concentration in biological fluids (such as serum, plasma, whole blood, urine, etc.). Its main principle is based on ion-selective electrode technology, using the selective recognition ability of each electrode for specific ions to determine the concentration value of the ion to be measured by measuring the change in electrode potential. Electrolyte analyzers are widely used in clinical medical testing, body fluid analysis, and patient health monitoring to help medical staff assess the patient's electrolyte balance.

[0003] Existing electrolyte analyzers usually go through a series of self-test and calibration operations after startup to ensure the accuracy and stability of their measurement results. During the calibration process, the system uses a predetermined calibration reagent (such as sodium, potassium standard solution, etc.) to calibrate the slope value and bias value of each ion selective electrode. In general, self-test and calibration operations need to be performed regularly after each startup or during the measurement cycle to eliminate measurement errors caused by environmental factors and instrument aging.

[0004] Although the existing calibration scheme of electrolyte analyzers can ensure the reliability of measurement to a certain extent, there are still the following problems: after the calibration is completed, the accuracy of the initial test results cannot be effectively guaranteed in the subsequent sample testing due to the possible fluctuation of the electrode state or the calibration process not fully reflecting the actual working state of the electrode. This problem is particularly obvious when the electrode has a long service life, is not adequately maintained, or the environmental conditions (such as temperature and humidity) change greatly during calibration.

[0005] Therefore, the electrode slope value obtained during the calibration process of the existing scheme does not completely match the electrode state during sample detection, thereby affecting the final detection accuracy. Summary of the invention

[0006] In view of this, embodiments of the present invention provide a control method, device, system and storage medium for an electrolyte analyzer, so as to solve the problem that the electrode slope value obtained during the calibration process in the prior art does not completely match the electrode state during sample detection, thereby affecting the final detection accuracy. In a first aspect, embodiments of the present invention provide a control method for an electrolyte analyzer, the method comprising: In response to a power-on instruction, controlling the electrolyte analyzer to perform a self-test to obtain a self-test result; In response to the self-test result satisfying a preset self-test condition, controlling the electrolyte analyzer to perform calibration according to a preset calibration rule to obtain a calibration result; In response to the calibration result satisfying a preset calibration condition, controlling the electrolyte analyzer to detect the sample to be tested to obtain an initial test result; The initial detection result is corrected according to the calibration result to obtain the target detection result of the sample to be tested.

[0007] Preferably, in response to the self-test result satisfying a preset self-test condition, controlling the electrolyte analyzer to perform calibration according to a preset calibration rule to obtain a calibration result includes: Determine whether the displayed self-test result meets the preset self-test condition; If satisfied, obtaining a preset calibration cycle, wherein the preset calibration cycle includes several calibration stages; Alternately controlling the electrolyte analyzer to calibrate in each calibration stage by using a first calibration reagent and a second calibration reagent to obtain first calibration data; According to the CO2 standard reagent, controlling the electrolyte analyzer to perform TCO2 calibration to obtain second calibration data; The calibration result is obtained according to the first calibration data and the second calibration data.

[0008] Preferably, the step of alternately controlling the electrolyte analyzer to perform calibration in each calibration stage by using the first calibration reagent and the second calibration reagent to obtain the first calibration data comprises: Controlling the electrolyte analyzer to perform calibration according to the first calibration reagent with a preset sample aspiration amount, and continuously collecting the voltage value of each electrode during the calibration stage; When the difference between two adjacent voltage values ​​collected at each electrode during the calibration phase is less than a preset voltage difference threshold or the duration of the calibration phase exceeds a preset waiting time, the electrolyte analyzer is controlled to be calibrated according to the preset sample aspiration amount of the second calibration reagent, and the voltage value of each electrode is continuously collected during the calibration phase; When the difference between two adjacent voltage values ​​collected at each of the electrodes in the calibration phase is less than a preset voltage difference threshold or the duration of the calibration phase exceeds a preset waiting time, return to control the electrolyte analyzer to calibrate according to the first calibration reagent with a preset sample aspiration amount, and continue to collect the voltage value of each electrode in the calibration phase until the preset calibration cycle ends, and obtain the first potential data of each electrode in each calibration phase; Obtaining the slope value of each electrode according to the first potential data and the Nernst equation in a specified calibration phase, wherein the specified calibration phase includes the second calibration phase and the fourth calibration phase in the preset calibration cycle; The first calibration data is obtained according to the first potential data of each electrode and the slope value in each calibration stage.

[0009] Preferably, in response to the calibration result satisfying a preset calibration condition, controlling the electrolyte analyzer to detect the sample to be tested to obtain an initial detection result includes: Determining whether the calibration result meets the preset calibration condition; If the conditions are met, the electrolyte analyzer is controlled to absorb the sample to be tested according to the preset sample adsorption amount, so that the sample to be tested completely covers the measuring area of ​​each electrode; Determining a signal acquisition time according to a sample type of the sample to be tested; Controlling each of the electrodes to analyze the sample to be tested according to the signal acquisition time to obtain an initial analysis result of each of the electrodes; The initial detection result is obtained according to the initial analysis result of each electrode.

[0010] Preferably, the correcting the initial detection result according to the calibration result to obtain the target detection result of the sample to be tested includes: Acquire the potential data of the electrode at a preset time in the last calibration stage in the preset calibration cycle, and record it as first calibration data; Controlling the electrolyte analyzer to perform calibration according to the first calibration reagent to obtain potential data of each electrode at the preset time during the calibration process, which is recorded as second calibration data; Adjusting the slope value of each of the electrodes according to the difference between the first correction data and the second correction data; Correcting the initial analysis result of each electrode according to the adjusted slope value to obtain a first corrected analysis result; According to the preset extended Nernst equation, the first correction analysis result of the designated electrode is adjusted to obtain a second correction analysis result; A target detection result of the sample to be tested is obtained according to the first calibration analysis result and the second calibration analysis result.

[0011] Preferably, the designated electrode includes at least a lithium electrode and a magnesium electrode, and the first correction analysis result of the designated electrode is adjusted according to the preset extended Nernst equation to obtain the second correction analysis result, including: Obtaining an interfering ion corresponding to the lithium electrode as a first interfering ion, wherein the first interfering ion is a sodium ion; Obtaining an interfering ion corresponding to the magnesium electrode as a second interfering ion, wherein the second interfering ion is a calcium ion; According to the preset extended Nernst equation, the ion parameters of the first interfering ion and the second interfering ion, the first correction analysis result of each designated electrode is adjusted to obtain the corresponding second correction analysis result, wherein the ion parameters include activity and charge number, and the expression of the preset extended Nernst equation is: Where, E is the potential measurement value of the specified electrode, E 0 is the standard electrode potential, R is the gas constant, F is the Faraday constant, T is the absolute temperature, i is the ion to be measured, j is the interfering ion, a i and a j are the activities of the ion to be measured and the interfering ion, respectively, i is the charge number of the ion to be measured, z j is the charge number of the interfering ion, k ij is the selectivity coefficient between the ion to be measured and the interfering ion.

[0012] Preferably, adjusting the first calibration analysis result of each designated electrode according to the preset extended Nernst equation, the first interfering ion and the second interfering ion to obtain the corresponding second calibration analysis result includes: Respectively dividing the concentration ranges of the first interfering ion and the second interfering ion to obtain a first concentration interval and a second concentration interval, wherein the first concentration interval and the second concentration interval both include a high concentration interval, a medium concentration interval, and a low concentration interval; For each of the first concentration intervals, a preset number of first mixed solutions are obtained, wherein the first mixed solutions include first interfering ions and corresponding ions to be detected, and different first mixed solutions have different concentration ratios of the first interfering ions and the corresponding ions to be detected; For each of the second concentration intervals, a preset number of second mixed solutions are obtained, wherein the second mixed solutions include second interfering ions and corresponding ions to be measured, and different second mixed solutions have different concentration ratios of the second interfering ions and the corresponding ions to be measured; Obtaining a first multi-point calibration data set corresponding to each of the first concentration intervals according to the potential values ​​of the lithium electrode in all the first mixed solutions; Obtaining a second multi-point calibration data set corresponding to each of the second concentration intervals according to the potential values ​​of the magnesium electrode in all the second mixed solutions; Fitting the first multi-point calibration data set and the second multi-point calibration data set by linear fitting or polynomial fitting to obtain a first functional relationship between the selectivity coefficient in different first concentration intervals and the concentration of the first interfering ion and a second functional relationship between the selectivity coefficient in different second concentration intervals and the concentration of the second interfering ion; According to the actual concentrations of the first interfering ion and the second interfering ion in the sample to be tested, obtaining the corresponding first selectivity coefficient and the second selectivity coefficient through the first functional relationship and the second functional relationship; According to the first selectivity coefficient, the second selectivity coefficient and the preset extended Nernst equation, the first correction analysis result of each designated electrode is adjusted respectively to obtain a corresponding second correction analysis result.

[0013] In a second aspect, an embodiment of the present invention further provides a control device for an electrolyte analyzer, the device comprising: A self-test module, for responding to a power-on instruction, controlling the electrolyte analyzer to perform a self-test and obtain a self-test result; A calibration module, configured to control the electrolyte analyzer to perform calibration to obtain a calibration result according to a preset calibration rule in response to the self-test result satisfying a preset self-test condition; A detection module, configured to control the electrolyte analyzer to detect the sample to be tested and obtain an initial detection result in response to the calibration result satisfying a preset calibration condition; The calibration module is used to calibrate the initial detection result according to the calibration result to obtain the target detection result of the sample to be tested.

[0014] In a third aspect, an embodiment of the present invention provides an electrolyte analysis system, comprising: an electrolyte analyzer and a controller, wherein the controller controls the electrolyte analyzer by executing the control method of the electrolyte analyzer described in the first aspect.

[0015] In a fourth aspect, an embodiment of the present invention provides a storage medium having computer program instructions stored thereon, which implements the method of the first aspect in the above-mentioned embodiment when the computer program instructions are executed by a processor.

[0016] In summary, the beneficial effects of the present invention are as follows: The control method, device, system and storage medium of the electrolyte analyzer provided by the embodiment of the present invention can timely identify the hardware fault of the system before the instrument enters the working state through the self-check operation at startup, prevent the measurement failure or error increase caused by the faulty operation, and the self-check process can improve the operation safety and reliability of the equipment, reduce the risk of mismeasurement caused by hardware failure, and ensure the effectiveness of the subsequent calibration and sample detection process. By judging whether the self-check result meets the preset conditions, the equipment can be prevented from entering the calibration step if the self-check fails, avoiding the miscalibration operation under the fault state, thereby improving the working stability of the system. The calibration process can correct the characteristic parameters of each electrode before the instrument starts the sample detection, eliminate the deviation caused by the aging of the electrode or the change of the external environment, and ensure the reference accuracy of the measurement. By judging whether the calibration result meets the preset conditions, it can be ensured that the sample detection is only performed when the calibration result is stable and accurate, thereby improving the accuracy of the sample analysis and avoiding the detection error caused by the calibration abnormality. The judgment of the calibration condition can reflect the working state of the electrode in the actual measurement to a certain extent, so that the initial detection result can be closer to the true characteristics of the sample. Correcting the initial test results based on the calibration results can eliminate the measurement deviation caused by electrode state fluctuations or calibration errors, making the target test results more accurate and stable. Through the correction operation, the measurement error caused by unstable electrode performance or improper maintenance can be reduced, and the consistency and reliability of the measurement can be improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] In order to more clearly illustrate the technical solution of the embodiment of the present invention, the drawings required for use in the embodiment of the present invention will be briefly introduced below. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work, and these are all within the protection scope of the present invention.

[0018] Figure 1 The present invention is a flowchart of a control method for an electrolyte analyzer according to an embodiment of the present invention.

[0019] Figure 2 The present invention is another flowchart of a control method for an electrolyte analyzer according to an embodiment of the present invention.

[0020] Figure 3 4 is a timing diagram of each calibration stage in a calibration cycle of an embodiment of the present invention.

[0021] Figure 4 It is a schematic structural diagram of a control device of an electrolyte analyzer according to an embodiment of the present invention. DETAILED DESCRIPTION

[0022] The features and exemplary embodiments of various aspects of the present invention will be described in detail below. In order to make the purpose, technical solutions and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and Examples. It should be understood that the specific embodiments described herein are only configured to explain the present invention and are not configured to limit the present invention. For those skilled in the art, the present invention can be implemented without the need for some of these specific details. The following description of the embodiments is only to provide a better understanding of the present invention by illustrating examples of the present invention.

[0023] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, the elements defined by the statement "include..." do not exclude the presence of other identical elements in the process, method, article or device including the elements.

[0024] It should be noted that all actions of acquiring signals, information or data in the present invention are performed in compliance with the corresponding data protection laws and policies of the location and with the authorization given by the owner of the corresponding device.

[0025] Example 1

[0026] See also Figure 1 , an embodiment of the present invention provides a control method for an electrolyte analyzer, the method comprising: S1, in response to a power-on instruction, controlling the electrolyte analyzer to perform a self-test to obtain a self-test result, wherein the self-test result includes a motor self-test result, a distribution valve test result, a storage chip test result, and a liquid circuit test result; Specifically, after the electrolyte analyzer is started, in order to ensure that the equipment can stably and accurately complete the subsequent calibration and sample detection operations, the system will perform comprehensive self-test operations on each core component in turn according to the preset process. First, multiple key motors in the electrolyte analyzer are tested one by one to ensure that each motor can operate normally according to the predetermined parameters and motion accuracy. The motor self-test results include peristaltic pump motors, distribution valve electrodes, injection needle motors, injection plate motors, CO2 reaction liquid motors, etc. By testing multiple motors one by one, it can be ensured that during the sample and reagent delivery process, all transmission motors can meet stable and accurate motion standards, avoiding sample confusion, transmission volume errors or measurement abnormalities caused by motor failure or positioning offset.

[0027] The distribution valve is then tested. The distribution valve is used to select different liquids (such as samples, liquid A, liquid B, auxiliary liquid) for channel switching. The working position detection of the distribution valve is a key link in the self-test. During the self-test, the system detects the sensor feedback signal of the distribution valve at each position to confirm that it can accurately reach and stay at each set position. In particular, the system will detect whether the signal change at each position is as expected (for example, when the distribution valve is switched to the "air position", the corresponding liquid path should show a state where no liquid passes), so as to judge the channel switching ability and position control accuracy of the distribution valve. By accurately detecting the position of each distribution valve, it can be ensured that during the sample measurement or calibration process, different reagents and samples can be accurately distributed to their respective liquid channels to avoid cross-contamination of reagents or confusion of samples.

[0028] The memory chip is used to store important parameters of the electrolyte analyzer (such as correction factors, calibration data, user settings, etc.). The chip detection steps are designed to determine whether it can read and write data correctly. During self-test, the system will read the known test data of a specific storage area from the memory chip and perform a checksum calculation to determine whether the read data matches the expected value. If the read data checksum is wrong, the system will determine that there is a data read and write error or damage to the chip, and prompt the operator to replace or repair it. The memory chip detection can promptly detect measurement errors caused by data storage damage or data transmission errors, thereby avoiding inaccurate measurement results due to incorrect calibration parameters.

[0029] The liquid path system is an important component used to transmit samples and reagents in electrolyte analyzers. Liquid path patency detection is the basis for ensuring that various liquids can smoothly enter each reaction chamber according to the predetermined process. Liquid detectors are used to determine whether each liquid path (including sample liquid path, calibration liquid path, reaction liquid liquid path, etc.) has abnormal conditions such as blockage, leakage or liquid shortage. The system will switch each liquid channel one by one, detect the flow state of each channel and the liquid transmission speed (through feedback signals from sensors such as pressure and flow rate), determine whether the liquid can be smoothly transmitted to the predetermined position, and ensure that various reagents are prepared in place. Through liquid path patency detection, measurement failures or errors caused by problems such as poor liquid transmission, bubble blockage or liquid shortage can be prevented, thereby ensuring the continuity and stability of the measurement.

[0030] After the self-test is completed, the system will integrate the test data of each self-test link to generate a comprehensive self-test report (i.e., self-test result). The self-test result includes the status information of each motor, distribution valve, storage chip, and liquid circuit. By analyzing the self-test results, the system can determine whether the current device meets the requirements of subsequent calibration and sample testing operations.

[0031] The self-check operation can comprehensively check the working status of each core component before the instrument officially starts measuring, ensuring that faults are discovered and eliminated before the equipment starts working, thereby improving the measurement reliability of the equipment and avoiding measurement errors or sample waste caused by hardware problems.

[0032] S2, in response to the self-test result satisfying a preset self-test condition, controlling the electrolyte analyzer to perform calibration according to a preset calibration rule to obtain a calibration result; Specifically, after the self-test is completed and all self-test items meet the preset conditions (i.e., the motor, dispensing valve, storage chip, liquid circuit, etc. are all working properly), the electrolyte analyzer enters the calibration step. The purpose of calibration is to ensure that each electrode can achieve accurate and stable working conditions before sample measurement. Calibration usually uses standard reagents of known concentrations (such as high and low concentrations of sodium and potassium reagents) to determine the response curve of the electrode, and calculates the slope and offset of the electrode according to the Nernst Equation. During the calibration process, the system uses calibration reagents of different concentrations in a predetermined order to react with each electrode in turn, collect the potential data of the electrode, and calculate the response characteristics of the electrode. The system obtains the slope value, offset value or selectivity coefficient of each electrode by fitting or calculation based on the collected electrode potential data and the known concentrations of each calibration reagent. The calibration result is the final output of the entire calibration process, including key parameters such as the slope and intercept of each electrode. These parameters will be used to calibrate the subsequent sample measurement results to ensure the accuracy of the measurement results.

[0033] Preferably, refer to Figure 2In response to the self-test result satisfying a preset self-test condition, controlling the electrolyte analyzer to calibrate according to a preset calibration rule to obtain a calibration result, including: S21, determining whether the displayed self-test result meets the preset self-test condition; Specifically, before the calibration begins, the system first checks the self-test results obtained in the self-test step (i.e., step S1) to determine whether the preset self-test conditions for entering the calibration phase are met. The standards for setting the self-test conditions usually involve the integrity of the hardware equipment, the smoothness of the liquid circuit, and the status of key functional components. For example, all key motors (such as peristaltic pump motors, sample plate motors, distribution valve motors, etc.) can start and rotate normally, and reach the expected speed and position within the specified time; all liquid level sensors, voltage sensors, etc. can work normally without abnormal output; the status of each pipeline and valve in the liquid circuit is normal, and the liquid can flow freely between each path, read the known data in the specific area of ​​the storage chip, calculate its checksum, and ensure that the read and write functions of the storage chip are normal without data loss or error. If all of the above conditions are in the "pass" state, the self-test conditions are met and the calibration phase can be entered. If any one of the conditions is unqualified (such as motor failure, liquid circuit blockage, chip failure), the self-test conditions are all "unsatisfied", and the system will report an error and stop the operation.

[0034] S22. If the conditions are met, obtain a preset calibration cycle, wherein the preset calibration cycle includes several calibration stages; Specifically, after confirming that the self-test conditions are met, the system obtains the current calibration cycle according to the internally stored calibration rules. The preset calibration cycle refers to a series of operations performed by the system in accordance with the specified time sequence and reagent switching strategy during the calibration process. The preset calibration cycle usually includes multiple calibration stages, and each stage has different calibration reagents. The preset calibration cycle ensures the standardization and repeatability of the calibration process, so that each calibration can follow the same steps, thereby improving the reliability of the calibration results. The calibration cycle includes at least 4 calibration stages. The number of calibration stages is an important factor in optimizing the performance of the electrolyte analyzer. It should be determined based on multiple factors such as actual needs, sample characteristics, and equipment calibration accuracy. For applications with higher precision requirements, such as ion concentration determination in medical testing, multiple stages such as 6-8 can be set to ensure that the results are reliable; S23, alternately controlling the electrolyte analyzer to perform calibration in each calibration stage by using a first calibration reagent and a second calibration reagent to obtain first calibration data, wherein the first calibration data includes a slope value of each electrode; After the calibration cycle begins, the system will calibrate each electrode one by one using different calibration reagents in a predetermined order, and collect the response data (voltage or current value) of the electrode to obtain the first calibration data. The first calibration reagent and the second calibration reagent are usually two standard solutions of known concentrations. In each calibration stage, the system controls the corresponding reagents to flow through each electrode and collects the voltage data of the electrode in real time. At the end of the calibration stage, the system calculates the average potential value of each electrode. The system fits the known concentration of each calibration reagent with the potential data of the electrode, and calculates the slope value (Slope) of each electrode through the Nernst equation or its extended form to reflect the response sensitivity of the electrode. After the calibration is completed, the system outputs the first calibration data of each electrode, which includes: the potential value of each electrode under different reagents, the calculated slope value and other characteristic parameters.

[0035] Alternating between two different calibration reagents can effectively evaluate the linear response characteristics of the electrode, ensuring that the calibration results can reflect the sensitivity and accuracy of the electrode in different concentration ranges. By calculating the slope value, the response characteristics of the electrode can be quantified, which serves as an important basis for ion concentration conversion when measuring samples.

[0036] Preferably, the step of alternately controlling the electrolyte analyzer to perform calibration in each calibration stage by using the first calibration reagent and the second calibration reagent to obtain the first calibration data comprises: S231, controlling the electrolyte analyzer to perform calibration according to the first calibration reagent with a preset sample aspiration amount, and continuously collecting the voltage value of each electrode during the calibration stage; Specifically, this step first performs calibration by using a first calibration reagent with a preset sample volume, starts the calibration process of the electrolyte analyzer, and uses the first calibration reagent to obtain the voltage response data of the electrode under the reagent. During this calibration phase, the system continuously monitors and records the voltage value of each electrode to capture the response of each electrode to the first calibration reagent.

[0037] S232, when the difference between two adjacent voltage values ​​collected at each electrode in the calibration phase is less than a preset voltage difference threshold or the duration of the calibration phase exceeds a preset waiting time, the electrolyte analyzer is controlled to be calibrated according to the preset sample aspiration amount of the second calibration reagent, and the voltage value of each electrode is continuously collected in the calibration phase; Specifically, during the calibration process, if a calibration stage meets the preset switching condition, it switches to the next calibration stage. In this embodiment, the preset switching condition includes that the difference between the voltage values ​​collected twice by each electrode in the calibration stage is less than the preset voltage difference threshold or the duration of the calibration stage exceeds the preset waiting time. First, it is determined whether the voltage of the electrode is stable. If it is stable, it switches to the next calibration stage and calibrates with the second calibration reagent. Whether it is stable can be determined by real-time monitoring of the voltage value of the electrode and comparing the two adjacent sampling data. If the difference between the two adjacent voltage values ​​of all electrodes is less than the preset voltage difference threshold (such as 0.1 mV), the current calibration stage can be ended; at the same time, a preset waiting time is also set, and the preset waiting time allows the system to perform sufficient voltage stability monitoring in each calibration stage. By giving the electrode enough time to reach a stable state, the misjudgment caused by the fluctuation of the electrode data in a short time can be effectively reduced. Only when the voltage is stable can reliable calibration data be obtained. The preset waiting time provides a fault-tolerant mechanism. For some electrodes, it may take longer to stabilize due to poor maintenance or aging. By setting a maximum waiting time (e.g., 20 seconds), the system can tolerate fluctuations in these electrodes within a normal range and avoid interrupting the calibration process due to occasional signal instability.

[0038] In one embodiment, when the duration exceeds a preset waiting time, the corresponding electrodes are marked, which often indicates that the performance of these electrodes may be affected due to long-term lack of maintenance.

[0039] In another embodiment, after step S231 and before step S232, the method further includes: determining whether the current calibration stage satisfies a preset switching condition, specifically including: S2311, periodically collecting instantaneous voltage values ​​of each electrode, and storing the instantaneous voltage values ​​in a data buffer; In this step, the electrolyte analyzer reads the voltage signal from the electrode at a fixed time interval (periodic) and puts the instantaneous voltage value into the data buffer. The data buffer here can be a queue or list, which is used to store the voltage values ​​of several recent samples for subsequent processing. Through continuous sampling, it is ensured that there is enough voltage data for smoothing and stability judgment. Periodic acquisition enables the system to monitor the dynamic changes of electrode potential over time, laying a data foundation for subsequent denoising and analysis.

[0040] S2312, performing smoothing processing on the voltage data in the data buffer, wherein the smoothing processing includes performing moving average on a preset number of recent collected values, or performing exponential smoothing on a current collected value and a previous smoothed value, to obtain a smoothed voltage value at the current moment; In this step, the raw voltage values ​​collected multiple times are calculated and processed using multiple data stored in the buffer to remove high-frequency noise and instantaneous mutations. Common smoothing methods include: Moving average: take the average of the most recent N voltage values ​​to obtain a relatively stable voltage reference value. Using the method of E_smooth = α*E_new + (1-α)*E_old (where 0<α<1), newer data is given a higher weight, so as to quickly track trends while reducing the impact of sudden noise. Smoothing reduces the amplitude of data fluctuations, which helps to more accurately compare the differences between adjacent reference values ​​in subsequent steps, thereby improving the reliability of voltage stability judgment.

[0041] S2313, taking the smoothed voltage value as the current reference voltage value, and comparing it with the smoothed voltage value obtained last time, and calculating the difference between the two smoothed voltage values; After obtaining the smoothed voltage value at the current moment, use it as the current reference voltage value E_ref and compare it with the smoothed voltage value E_ref_old obtained in the previous iteration. By calculating the difference between the two, ΔE = |E_ref - E_ref_old|, the change between the current voltage value and the previous stable value can be determined. Since it has been smoothed, the difference here can basically represent the trend change rather than random noise, making the determination of stability more accurate. Using the difference as the basis for determination and evaluating the magnitude of the voltage change in a quantitative manner can help determine whether the electrode potential is stabilizing.

[0042] S2314: if the difference is less than a preset voltage difference threshold, determine that the electrode voltage tends to be stable; In this step, if ΔE (the difference between two smoothed voltage values) is less than the set voltage difference threshold, it means that the electrode voltage changes very little in two consecutive smoothing calculations, that is, the electrode potential approaches a certain stable value.

[0043] S2315: If the difference is greater than the preset voltage difference threshold, return to S2311; If ΔE is still large, it means that the current voltage value has not reached a stable state, and data collection and subsequent smoothing processing need to be continued. At this time, the process will return to step S2311, periodically collect new instantaneous voltage values ​​and repeat the entire judgment process until the voltage reaches a stable state or reaches a preset timeout condition.

[0044] Repeat the above judgment steps before reaching the preset waiting time. If the difference value is continuously less than the preset voltage difference threshold value during the preset waiting time, the voltage stability judgment is completed. If the stability condition is still not reached after exceeding the preset waiting time, the calibration phase is terminated and the corresponding status information is recorded. Through the synergy of the above five steps, the scheme organically combines the original instantaneous voltage sampling, data smoothing, difference comparison and cyclic judgment. The smoothing algorithm can be used to reduce the impact of instantaneous interference, so that the voltage value can better represent the real steady-state of the electrode. The difference between adjacent reference values ​​after smoothing is used to judge whether the voltage is stabilizing, reducing the misjudgment caused by single sampling fluctuations. When the electrode is stable, the judgment ends immediately, saving time; if the voltage is not stable yet, it will continue to observe automatically to ensure that the final potential data is reliable enough. Without the need for additional parameter manual adjustment, the direction and timing of the next action can be automatically determined according to the data, improving the intelligence of the entire electrolyte analyzer.

[0045] S233, when the difference between two adjacent voltage values ​​collected at each of the electrodes in the calibration phase is less than a preset voltage difference threshold or the duration of the calibration phase exceeds a preset waiting time, return to control the electrolyte analyzer to calibrate according to the first calibration reagent of the preset sample aspiration volume, and continue to collect the voltage value of each electrode in the calibration phase until the preset calibration cycle ends, and obtain the first potential data of each electrode in each calibration phase; Specifically, similar to step S232, determine whether the voltage data of the second calibration stage is stable, or whether the duration of this stage exceeds the preset waiting time. If the conditions are met, switch to the next calibration stage, and continue calibration using a calibration reagent different from that of this stage until the preset calibration cycle ends. Record the voltage value in each stage to obtain the first potential data of each electrode.

[0046] Specifically, in one embodiment, refer to Figure 3 , a timing diagram of a preset calibration cycle, which includes five calibration stages, each stage alternately using the first calibration reagent A and the second calibration reagent B for calibration; the first calibration stage t1 uses reagent A to calibrate the initial electrode performance and collect the initial voltage value of the electrode; the second calibration stage t2 switches to reagent B to detect the performance changes of the electrode in the reagent B environment and collect voltage data. The third calibration stage t3 returns to reagent A, analyzes the impact of the previous reagent B on the electrode performance, and corrects the electrode performance parameters. The fourth calibration stage t4 uses reagent B again to verify the stability of the electrode and capture a new round of voltage data. The fifth calibration stage t5 uses reagent A to complete the final calibration, correct the electrode data of all stages, and obtain the final calibration result.

[0047] It should be noted that the accuracy and stability of the calibration process using the same preset sample volume in the three calibration steps S231, S232, and S233 depends not only on the characteristics of the electrode itself, but also on the conditions of use of the calibration reagent. If there are differences in the sample volume in each step, additional variables may be introduced, making it difficult to distinguish whether the change in the electrode's response to the signal is caused by a change in the electrode state or by different sample volumes. Unifying the sample volume can significantly reduce this uncertainty, making the calibration process simpler and more controllable, and the calibration results more repeatable and reliable. The potential response and signal stability of the electrode are related to the volume of the solution it contacts and the ion concentration environment. When the sample volume remains consistent, the volume of solution contacted by the electrode each time is similar, and the interface conditions formed by the solution on the electrode surface are also relatively stable and predictable. Such control is conducive to the rapid stabilization of the potential, thereby more efficiently judging whether the difference between two adjacent voltage acquisition values ​​is less than the threshold. When the sample volume remains fixed in the three steps, if the calibration data is abnormal or the time required for the electrode to reach stability changes abnormally, engineers or technicians can more easily troubleshoot the system and tune parameters. Because the sample volume parameter is fixed, analysts can give priority to other factors (such as reagent problems, electrode status, pipeline patency, acquisition circuit stability, etc.), reducing the difficulty of problem location. During the calibration stage, if you need to switch back and forth between different reagents, if the sample volume is different each time you switch, the electrode needs to be rebalanced under different solution volume conditions, which may increase the time required for the electrode signal to stabilize. A consistent sample volume allows the electrode to alternately contact the reagent under a relatively fixed liquid phase volume condition, reducing the time to adapt to new conditions and increasing the efficiency of the voltage value reaching a stable state, thereby improving the overall calibration efficiency.

[0048] In general, the beneficial effects of using the same preset sample aspiration volume in steps S231, S232 and S233 are: by maintaining the consistency of operating conditions during the calibration process, the accuracy and stability of the calibration results can be improved, the instrument control and debugging process can be simplified, and the calibration efficiency and repeatability can be improved.

[0049] S234, obtaining the slope value of each electrode according to the first potential data of the specified calibration stage and the Nernst equation, wherein the specified calibration stage includes the second calibration stage and the fourth calibration stage in the preset calibration cycle; Specifically, the recorded potential value is obtained from the specified calibration stage, and the specified calibration stage includes the second calibration stage and the fourth calibration stage in the preset calibration cycle; selecting these stages can ensure that the acquired data is more representative and avoid errors caused by transient effects that may occur in the initial stage. Specifically, the second calibration stage is usually after the first calibration stage, and the electrode has begun to adapt to the new calibration environment, so it is more likely to reach a stable measurement state. The fourth calibration stage is at the end of the entire calibration cycle. At this time, the system has undergone multiple alternating calibrations and the response of the electrode has also tended to stabilize. Therefore, the data from these two stages can better reflect the performance of the electrode under stable conditions.

[0050] In addition, although the other calibration stages are not directly used to specify the final calculation of the calibration data, they still play an important auxiliary or supplementary role in the entire calibration cycle. Specifically, the first calibration stage is mainly used to initialize the calibration cycle and detect the basic state of the electrode, including the initial potential and performance of the electrode; the third calibration stage is located in the middle of the calibration cycle, and the first calibration reagent is used for recalibration to check whether the electrode performance remains consistent during the calibration process; through the calibration data of the third stage, the response trend of the electrode can be discovered and adjusted in real time. If the performance fluctuation is found to exceed the preset range, further processing can be triggered. The last stage is used to verify the integrity of the entire calibration cycle and ensure the accuracy of the data of all previous stages. It also provides the final electrode performance data, which can be compared with the data of the first stage to detect whether the electrode has drifted.

[0051] Finally, the slope value of each electrode was calculated according to the Nernst equation, reflecting the response sensitivity of the electrode to concentration changes.

[0052] S235. Obtain the first calibration data according to the first potential data of each electrode and the slope value in each calibration stage.

[0053] Finally, the first potential data of each electrode at different calibration stages are integrated with the calculated slope value.

[0054] S24, controlling the electrolyte analyzer to perform TCO2 calibration according to the CO2 standard reagent to obtain second calibration data; For CO2 electrodes, their working principle is different from that of ordinary ion-selective electrodes. They are usually calibrated by contacting with CO2 reaction liquid to generate CO2 gas. This step is specifically for calibrating CO2 electrodes. The CO2 standard reagent is a carbon dioxide reaction liquid with a known concentration. When reacting with the CO2 electrode, carbon dioxide gas will be generated. The introduced CO2 standard liquid interacts with the reaction liquid inside the instrument to produce a chemical reaction and produce gas. The generation of these gases is based on the reaction of CO2 with water and other components in the solution to form carbonic acid (H2CO3), which is then further dissociated into carbon dioxide molecules and ions, increasing the gas pressure inside the cavity. Due to the gas produced by the reaction, the gas pressure in the closed cavity gradually increases. This process is dynamic, and the change in gas pressure is directly related to the CO2 concentration. The gas pressure value in the cavity reflects the change in the concentration of CO2 in the liquid, providing a physical basis for subsequent measurements. The pressure sensor is used to monitor the change in gas pressure in the cavity. The sensor converts the gas pressure in the cavity into an electrical signal and outputs a corresponding voltage or current signal. These signals are directly related to the CO2 concentration and provide the necessary measurement data for the calibration process. In the electrical signal obtained by the pressure sensor, multiple measurements are performed to ensure the accuracy and reliability of the data. Through multiple measurements, the random errors that may be caused by a single measurement can be eliminated, and more stable results can be obtained. These measurement results are averaged to obtain representative calibration data.

[0055] S25. Obtain the calibration result according to the first calibration data and the second calibration data.

[0056] Specifically, after the calibration cycle is completed, the system integrates all calibration data to form the final calibration result, and comprehensively analyzes the electrode slope in the first calibration data and the second calibration data of the CO2 electrode to determine whether the response curve of each electrode conforms to the linear law. The calibration results include the final slope, offset, selectivity coefficient, etc. of each electrode, and serve as the correction basis for subsequent sample measurements.

[0057] The calibration step can effectively eliminate the impact of factors such as electrode aging and ambient temperature changes on electrode performance, ensuring that each electrode can maintain a linear response characteristic during sample testing, thereby improving the accuracy of the measurement results.

[0058] S3, in response to the calibration result satisfying the preset calibration condition, controlling the electrolyte analyzer to detect the sample to be tested to obtain an initial test result; Specifically, after the calibration is completed and the calibration results meet the preset calibration conditions (such as the slope and offset of the electrode are within the allowable error range), the system enters the sample detection stage. The system controls the injection needle to draw the sample to be tested (such as blood or urine) from the sample bottle and inject it into the measurement chamber to ensure that the sample can completely cover the measurement area of ​​all electrodes. By checking the qualification of the calibration results, the system can effectively avoid measurement errors caused by poor electrode status and improve the reliability of sample detection. The initial detection results can promptly reflect the original concentration distribution of each ion in the sample, serving as the basic data for subsequent correction.

[0059] Preferably, in response to the calibration result satisfying a preset calibration condition, controlling the electrolyte analyzer to detect the sample to be tested to obtain an initial detection result includes: S31, determining whether the calibration result meets the preset calibration condition; Specifically, the preset calibration conditions are used to evaluate whether the calibration data obtained during the calibration process meets the expected standards of the system, so as to determine whether the next step of sample testing can be carried out. This condition is usually set according to indicators such as the stability, repeatability and accuracy of the calibration data. The preset calibration conditions may include checking whether the slope value of each electrode in the calibration data is within the set qualified range, or the system can perform repeated calibration multiple times to check whether the difference between multiple calibration data (such as slope value, offset) is within an acceptable range. Only when the calibration data of all electrodes meet the preset qualified standards can the calibration conditions be considered to be met and enter the sample detection stage. Otherwise, the system will prompt that the calibration has failed and stop the sample analysis.

[0060] S32, if satisfied, controlling the electrolyte analyzer to absorb the sample to be tested according to a preset sample adsorption amount, so that the sample to be tested completely covers the measuring area of ​​each electrode; Specifically, when the preset calibration conditions are met, the system controls the electrolyte analyzer to absorb the sample to be tested according to the preset adsorption amount of each sample, so that the sample to be tested completely covers the measuring area of ​​each electrode. Ensuring that the sample completely covers the measuring area of ​​each electrode can ensure that all electrodes can effectively contact the sample during the analysis process, thereby improving the accuracy of the detection.

[0061] S33, determining a signal acquisition time according to the sample type of the sample to be tested; Specifically, different types of samples may have different electrode reaction times, so the system will determine the signal acquisition time based on the properties of the sample to be tested to ensure that the sample's reaction process can be accurately captured. The system can adjust the acquisition time based on the set sampling frequency and expected accuracy. For example, measurements requiring high precision may result in extended signal acquisition time to ensure data accuracy.

[0062] S34, controlling each of the electrodes to analyze the sample to be tested according to the signal acquisition time, and obtaining an initial analysis result of each of the electrodes; Specifically, according to the determined time, the system controls the electrodes to analyze the sample to be tested. This process ensures that each electrode can react with the sample within the appropriate time. The system switches the electrode test channel through an analog switch and uses a high-speed AD (analog-to-digital conversion) chip to read the electrical signal of the electrode. This design can improve the speed and accuracy of data acquisition and ensure that the voltage signal after the electrode reaction can be obtained quickly and accurately. The collected electrical signals will be recorded and preliminarily analyzed to form the initial analysis results of each electrode. These initial results provide basic data for subsequent result processing.

[0063] S35. Obtain the initial detection result according to the initial analysis result of each electrode.

[0064] Finally, the initial analysis results obtained from each electrode are integrated to form a comprehensive test result. This process can reflect the electrolyte concentration of each component in the sample to be tested. The final initial test result will be used for subsequent result correction and reporting, providing basic data support for subsequent analysis. This result is an important basis for evaluating the sample to be tested.

[0065] S4. Correct the initial detection result according to the calibration result to obtain the target detection result of the sample to be tested.

[0066] Specifically, after obtaining the initial test results, the system corrects the original test data of each electrode according to the calibration results obtained in step S2 to eliminate the influence of electrode inconsistency, drift or cross-interference. By introducing the correction factor, the system can convert the response data of each electrode into the real ion concentration to ensure the accuracy and repeatability of the sample test results. The target test results finally obtained can accurately reflect the concentration of each ion in the sample and provide reliable data support for subsequent diagnosis and analysis.

[0067] Preferably, the correcting the initial detection result according to the calibration result to obtain the target detection result of the sample to be tested includes: S41, obtaining the potential data of the electrode at a preset time in the last calibration stage in the preset calibration cycle, and recording it as first calibration data; Specifically, the system will obtain the potential data of the electrode at a preset time from the last calibration stage in the preset calibration cycle. This data is called the first calibration data. The system records the potential of the electrode at a specified time point in the last calibration stage (such as a specific time at the end of calibration). The first calibration data provides baseline data for subsequent calibrations and can reflect the actual performance of the electrode under calibration. This is a reference for subsequent adjustments and calibrations.

[0068] S42, controlling the electrolyte analyzer to perform calibration according to the first calibration reagent, and obtaining the potential data of each electrode at the preset time during the calibration process, which is recorded as second calibration data; Specifically, in this step, the system will use the first calibration reagent to calibrate the electrolyte analyzer and obtain the potential data of each electrode during the calibration process, which is called the second calibration data. The first calibration data and the second calibration data are both potential data at a preset time. During the analysis and calibration process, the same time point is used to ensure data consistency. This allows potential data from different sources to be directly compared, which is convenient for identification and adjustment. Collecting data at a specific time can reduce fluctuations caused by time changes and ensure that the recorded data reflects the true state of the electrode during the calibration process.

[0069] S43, adjusting the slope value of each electrode according to the difference between the first correction data and the second correction data; Specifically, in electrolyte analysis, the potential value of the electrode may drift due to various factors (such as temperature changes, aging, etc.). This drift will lead to inaccurate measurement results, so correction is required. After completing the analysis of the sample to be tested, the system will absorb a section of the first calibration reagent and stay in the electrode measurement channel. The purpose of this operation is to maintain a stable test environment on the electrode to facilitate subsequent data collection and comparison. The system records the potential value at this time at a preset time (for example, the 5th second) and marks it as the second correction data. This moment is selected to ensure comparability with the previous test data. It is usually collected shortly after the sample test to capture the response of the electrode in this state. By calculating the difference between the second correction data and the previously recorded first correction data, the degree of drift of the electrode during this time period, that is, the change in the electrode response, is reflected. Then the potential data and the difference of the recorded specified calibration stage (the second and fourth calibration stages) are added to obtain a new potential value. These new potential values ​​will be substituted into the Nernst equation to obtain the corrected slope value.

[0070] S44, performing correction according to the adjusted slope value and the initial analysis results of each of the electrodes to obtain a first corrected analysis result; Specifically, the adjusted slope value is used to correct the initial analysis result of the electrode on the sample to be tested, so as to improve the accuracy and reliability of the data.

[0071] S45, adjusting the first correction analysis result of the designated electrode according to the preset extended Nernst equation to obtain a second correction analysis result; Specifically, the extended Nernst equation is used to calculate the impact on the electrode analysis results, and the results are corrected. Through the calculation of the equation, the impact of interfering ions on the electrode response can be compensated, thereby obtaining more accurate analysis results.

[0072] Preferably, the designated electrode includes at least a lithium electrode and a magnesium electrode, and the first correction analysis result of the designated electrode is adjusted according to the preset extended Nernst equation to obtain the second correction analysis result, including: S451, obtaining an interfering ion corresponding to the lithium electrode and recording it as a first interfering ion, wherein the first interfering ion is a sodium ion; Specifically, in the measurement of lithium electrodes, sodium ions are one of the main interfering ions. Since lithium ions and sodium ions have similar chemical properties, they will competitively affect the potential value of the lithium electrode during testing. In order to eliminate the interference of sodium ions on the lithium electrode, this interference effect needs to be taken into account in the calculation. The purpose of this step is to identify the types of ions that may interfere with the measurement of lithium electrodes and provide a basis for subsequent corrections.

[0073] S452, obtaining an interfering ion corresponding to the magnesium electrode and recording it as a second interfering ion, wherein the second interfering ion is a calcium ion; Similarly, in the test process of magnesium electrode, calcium ion is its main interfering ion. Magnesium ion and calcium ion have the same charge and certain similarities in physical and chemical properties, which can easily interfere with each other. The purpose of this step is to identify the calcium ion that interferes with the measurement results of magnesium electrode and provide a reference for subsequent correction.

[0074] S453, adjusting the first calibration analysis result of each designated electrode according to the preset extended Nernst equation, the ion parameters of the first interfering ion and the second interfering ion, to obtain a corresponding second calibration analysis result, wherein the expression of the preset extended Nernst equation is: Where, E is the potential measurement value of the specified electrode, E 0 is the standard electrode potential, R is the gas constant, F is the Faraday constant, T is the absolute temperature, i is the ion to be measured, j is the interfering ion, z is the i is the charge number of the ion to be measured, z j is the charge number of the interfering ion, k ij is the selectivity coefficient between the ion to be measured and the interfering ion.

[0075] Specifically, sodium ions interfere with the potential measurement of the lithium electrode, so they need to be corrected to ensure that the potential of the lithium electrode reflects the true concentration of lithium ions. Similarly, calcium ions have a similar effect on the measurement of the magnesium electrode, so their interference with the magnesium electrode also needs to be corrected to obtain the accurate magnesium ion concentration.

[0076] In order to correct the measurement results of lithium electrode and magnesium electrode, the extended Nerest equation, specifically Nicolsky-Shultz-Eisenman equation, is used. This equation allows the output of the electrode to be adjusted in the presence of interfering ions. It is an improved version of the classical Nernst equation and is used to consider the effect of multiple ions coexisting on the electrode potential. In practical applications, if it is assumed that there is only one major interfering ion in the system (for example, for lithium electrode, only the interference of sodium ions is considered), the extended Nernst equation can be simplified to reduce complexity. The expression of the simplified equation is: body, a H+ is the activity of the target ion, a Na+ For interfering ions (such as Na + ) activity.

[0077] K H + ,Na + It is the selectivity coefficient between the target ion and the interfering ion, indicating the difference in the electrode's response sensitivity to the two. The selectivity coefficient can be solved by preparing mixed solutions of different concentrations and eliminating the variables, which can effectively quantify the effect of interfering ions on the electrode potential, thereby more accurately reflecting the true concentration of the target ion, achieving the purpose of eliminating interference and improving measurement accuracy.

[0078] The core goal of equation simplification is to reduce the computational complexity when multiple interfering ions coexist, and by assuming the existence of a single interfering ion, the original expanded Nernst equation is converted into a binomial form (containing only the target ion and one interfering ion), which facilitates interference correction in actual measurement and data processing.

[0079] In one embodiment, the first calibration analysis result of each designated electrode is adjusted according to the preset extended Nernst equation, the first interfering ion, and the second interfering ion to obtain the corresponding second calibration analysis result, including: S4531, respectively dividing the concentration ranges of the first interfering ion and the second interfering ion to obtain a first concentration interval and a second concentration interval, wherein the first concentration interval and the second concentration interval both include a high concentration interval, a medium concentration interval, and a low concentration interval; In this step, we first need to remove two interfering ions (such as Na + and Ca² + ) to divide the concentration range. These interfering ions will affect the ions to be measured (such as Li + or Mg² +), so in order to reduce the impact of interference, its concentration range is first determined by experiment. Each interfering ion is divided into three concentration ranges: the low concentration range has a low concentration, which is usually the starting concentration or regular concentration of the interfering ion. The medium concentration range has a medium concentration, representing the common interfering ion concentration. The high concentration range has a high concentration, simulating the interference effect in a high concentration environment. This division helps to accurately establish the impact of interfering ions on electrode performance in each concentration range, and then accurately correct the measurement results of the electrode.

[0080] S4532. For each of the first concentration intervals, a preset number of first mixed solutions are obtained, wherein the first mixed solutions include first interfering ions and corresponding ions to be detected, and different first mixed solutions have different concentration ratios of the first interfering ions and the corresponding ions to be detected; Specifically, in this step, in order to obtain accurate calibration data, it is necessary to prepare a plurality of different mixed solutions for each defined first concentration interval, i.e., the first interfering ion concentration interval. Each solution contains the first interfering ion and the corresponding ion to be measured. The ratio of the interfering ion concentration to the ion concentration to be measured of each solution is different, and the purpose is to evaluate the influence of the interfering ions on the measurement at different concentration ratios and generate calibration data.

[0081] S4533. For each of the second concentration intervals, a preset number of second mixed solutions are obtained, wherein the second mixed solutions include second interfering ions and corresponding ions to be detected, and different second mixed solutions have different concentration ratios of the second interfering ions and the corresponding ions to be detected; This step is similar to S4532, except that this time the operation is performed on the second interfering ion. Each mixed solution should contain the second interfering ion and the ion to be measured. The concentration ratio of the second interfering ion to the ion to be measured in each solution is different. The purpose is to simulate the interference of different concentration ratios and evaluate its effect on the electrode potential. This step further evaluates the effect of the second interfering ion on the electrode performance through a variety of mixed solutions with different concentration ratios.

[0082] S4534, obtaining a first multi-point calibration data set corresponding to each of the first concentration intervals according to the potential values ​​of the lithium electrode in all the first mixed solutions; In this step, the potential values ​​are measured in the first mixed solution at different concentration ratios using a lithium electrode. These measurement results constitute a first multi-point calibration data set. The calibration data set includes the relationship between the potential value of the lithium electrode and the concentration of the first interfering ion and the concentration of the ion to be measured in the solution at different concentrations.

[0083] This data set helps to understand the effect of the first interfering ion on the lithium electrode potential at different concentration ranges and provides a basis for subsequent selectivity coefficient calculation and electrode correction.

[0084] S4535, obtaining a second multi-point calibration data set corresponding to each of the second concentration intervals according to the potential values ​​of the magnesium electrode in all the second mixed solutions; Similar to step S4534, in this step, the potential values ​​are measured in all second mixed solutions using the magnesium electrode to form a second multi-point calibration data set. By measuring the potential values ​​of the magnesium electrode in different solutions, the influence of the second interfering ion on the potential of the magnesium electrode is obtained.

[0085] This data set was used to subsequently determine the effect of the second interfering ion on the magnesium electrode measurement results and to provide data support for selectivity coefficient calculation and electrode calibration.

[0086] S4536. Fitting the first multi-point calibration data set and the second multi-point calibration data set by linear fitting or polynomial fitting to obtain a first functional relationship between the selectivity coefficient in different first concentration intervals and the concentration of the first interfering ion and a second functional relationship between the selectivity coefficient in different second concentration intervals and the concentration of the second interfering ion; In this step, a linear fitting or polynomial fitting method is used to fit the previously collected multi-point calibration data set. The goal is to obtain the relationship between the selectivity coefficient and the interfering ion concentration. The first functional relationship describes the relationship between the selectivity coefficient and the first interfering ion concentration in different first concentration intervals. The second functional relationship describes the relationship between the selectivity coefficient and the second interfering ion concentration in different second concentration intervals. By fitting these data, the mathematical relationship between the selectivity coefficient and the interfering ion concentration in different concentration intervals can be obtained, providing accurate parameters for subsequent calibration.

[0087] S4537. According to the actual concentrations of the first interfering ion and the second interfering ion in the sample to be tested, obtain the corresponding first selectivity coefficient and the second selectivity coefficient through the first functional relationship and the second functional relationship; In this step, the first selectivity coefficient and the second selectivity coefficient in the sample are calculated by combining the concentrations of the first interfering ions and the second interfering ions actually present in the sample to be tested with the first functional relationship and the second functional relationship obtained previously. These two coefficients reflect the degree of influence of the interfering ions in the sample to be tested.

[0088] S4538. According to the first selectivity coefficient, the second selectivity coefficient and the preset extended Nernst equation, the first correction analysis result of each designated electrode is adjusted respectively to obtain a corresponding second correction analysis result.

[0089] Finally, the first correction analysis result of the electrode is further adjusted using the obtained first selectivity coefficient and second selectivity coefficient, as well as the preset extended Nernst equation. The extended Nernst equation includes factors such as target ion concentration, interfering ion concentration, and selectivity coefficient. The second correction analysis result obtained by the calculation more accurately reflects the actual concentration of the target ion. This adjustment process eliminates the influence of interfering ions and optimizes the electrode measurement results, thereby improving the accuracy and reliability of the analysis.

[0090] In traditional methods, the selectivity coefficient is usually solved by preparing a mixed solution of several target ions and interfering ions with different concentrations. The electrode potential value is measured, and the data is substituted into the extended Nernst equation for analysis to obtain the selectivity coefficient value under one or a finite number of concentration combinations. The selectivity coefficient is regarded as a fixed parameter and applied to different concentration environments. However, in practice, the selectivity between ions may show nonlinear changes at different concentrations, resulting in a single selectivity coefficient that is insufficient to describe the complex concentration dependence.

[0091] Specifically, in the original method, the selectivity coefficient is obtained only under a single or limited concentration combination. The selectivity coefficient may be more accurate for this specific combination point, but when the concentration of the interfering ion deviates from this combination point, the error will increase.

[0092] In this embodiment, multi-point data are collected in each interval, and the trend of the selectivity coefficient changing with concentration is modeled through a fitting method. This makes it possible to obtain more realistic selectivity coefficient values ​​through interpolation or approximation at any interfering ion concentration, reduce the error caused by single-point extrapolation, and improve the accuracy and stability over the entire concentration range.

[0093] The original method assumes that k ij is a constant and cannot handle nonlinear relationships well. When multi-point fitting is selected and polynomial fitting is allowed, k can be plotted. ij The characteristics of the curve change with concentration. This is particularly important when there are complex interactions between ions and the chemical equilibrium is fine-tuned: nonlinear fitting makes the extended Nernst equation closer to the real conditions in actual sample analysis.

[0094] Moreover, a single selectivity coefficient is only applicable to the case where the interfering ion concentration is close to the test point. Once the ion concentration deviates far from the test point, the error will increase significantly. This embodiment uses a partitioning strategy, and each interval obtains a selectivity coefficient concentration function through multi-point fitting. When the interfering ion concentration varies in different ranges of low, medium, and high, the appropriate selectivity coefficient value can be extracted from the fitting function of the corresponding interval.

[0095] In this embodiment, the multi-point and partitioned data and function fitting relationship can be maintained and updated over time. If the data of multiple concentration points are updated regularly, the function parameters can be easily corrected so that the system can maintain stable accuracy during long-term use. This maintenance is simpler and more flexible, which is conducive to the long-term accurate measurement of the instrument.

[0096] S46. Obtain a target detection result of the sample to be tested according to the first calibration analysis result and the second calibration analysis result.

[0097] Finally, the first calibration analysis result and the second calibration analysis result are combined to ensure the integrity of the analysis results, thereby forming the target detection result of the sample to be tested, providing a basis for subsequent data interpretation and application.

[0098] These steps are designed to ensure that the electrolyte analyzer can accurately adjust and correct the response of the electrode during sample analysis, improving the accuracy and reliability of the final test results. Through repeated verification and adjustment of the calibration data, the system can better adapt to changes in different sample types and provide consistent analytical performance.

[0099] Preferably, at each preset time interval, in response to the calibration result satisfying a preset calibration condition, controlling the electrolyte analyzer to detect the sample to be tested, before obtaining an initial detection result, the method further comprises: S03, controlling the electrolyte analyzer to perform a quality control test to obtain a quality control test result, wherein the quality control test result includes quality control data of each electrode of the electrolyte analyzer; Specifically, at preset intervals (e.g., daily), before testing the samples to be tested, perform quality control tests to evaluate the performance of the electrolyte analyzer. Use your own quality control products or third-party quality control products to perform the test. This can include in-house quality control and inter-laboratory quality control. Obtain and record the quality control test results, including the quality control data of each electrode, and form a quality control chart (e.g., LJ quality control chart) for subsequent analysis.

[0100] S04. According to the quality control test result, determine whether the electrolyte analyzer is in a quality control controlled state; Specifically, the quality control test results are used to determine whether the product is in a "quality control controlled state" or a "quality control out of control state". The criteria for determination include: When any quality control test result exceeds the normal range of plus or minus two standard deviations, which means there may be a random error, a warning will be issued to remind the operator that the instrument status or related operations may need to be checked; If the quality control test results exceed plus or minus three times the standard deviation, it indicates that there is a significant random error, which may affect the reliability of the results. At this time, it indicates that the random error has increased and there may be problems with the equipment, which needs to be checked and calibrated.

[0101] If two consecutive quality control test results are both outside the range of plus or minus two standard deviations, this usually indicates a systematic error and the instrument performance may be unstable. The operator should immediately perform an instrument inspection and consider making necessary adjustments or maintenance; When the difference between two quality control test results of the same batch exceeds the mean plus or minus four times the standard deviation, it indicates that there is a significant random error, which may be caused by operation or instrument failure. The quality control process and instrument status need to be re-evaluated to ensure the accuracy of subsequent tests.

[0102] If the results of the same quality control product in four consecutive measurements are all outside the mean plus or minus one standard deviation, it indicates that the instrument may have a systematic error. The operator needs to calibrate or maintain the equipment in a timely manner to prevent error accumulation.

[0103] If seven consecutive QC results are all on the same side of the mean, this may mean that there is a bias in the system. The operator needs to check the instrument settings, reagent validity, and other factors that may cause the bias.

[0104] By setting the above standards, quality control testing can effectively monitor the performance of the electrolyte analyzer and detect potential problems in a timely manner. These judgment criteria ensure the accuracy and reliability of the testing process, thereby improving the credibility of the final test results.

[0105] S05. If the electrolyte analyzer is in a quality control controlled state, control the electrolyte analyzer to detect the sample to be tested to obtain an initial test result; The quality control test confirms that the instrument's working state meets the predetermined requirements and that its performance indicators (such as electrode slope, electrode potential deviation, baseline drift, etc.) are within the normal range. "In-control state" indicates that the instrument's reliability and detection accuracy have reached the standard and can continue to operate normally. Once it is confirmed that the instrument is in the quality control state, the detection process for the sample to be tested is started to obtain the initial test results.

[0106] S06. If the electrolyte analyzer is in a quality control out-of-control state, processing is performed according to the type of the quality control out-of-control state.

[0107] If the instrument is out of control, take appropriate measures. Specifically, for out-of-control conditions, the system needs to classify specific problems and take appropriate measures. The processing logic usually includes: Soft out-of-control: Minor anomalies such as drift or minor electrode slope deviation can be solved by recalibration, cleaning electrodes or adjusting environmental conditions; Hard out-of-control: Major anomalies such as sensor or system hardware damage may require downtime maintenance or replacement of parts; Feedback the out-of-control status and recommended operating steps to the user through the interface to ensure that the problem is quickly resolved.

[0108] Example 2

[0109] See also Figure 4 On the basis of Embodiment 1 of the present invention, Embodiment 2 of the present invention further provides a control device for an electrolyte analyzer, the device comprising: A self-test module, for responding to a power-on instruction, controlling the electrolyte analyzer to perform a self-test to obtain a self-test result, wherein the self-test result includes a motor self-test result, a distribution valve test result, a storage chip test result, and a liquid circuit test result; A calibration module, configured to control the electrolyte analyzer to perform calibration to obtain a calibration result according to a preset calibration rule in response to the self-test result satisfying a preset self-test condition; A detection module, configured to control the electrolyte analyzer to detect the sample to be tested and obtain an initial detection result in response to the calibration result satisfying a preset calibration condition; The calibration module is used to calibrate the initial detection result according to the calibration result to obtain the target detection result of the sample to be tested.

[0110] The control device of the electrolyte analyzer of the embodiment of the present invention can timely identify the hardware fault of the system before the instrument enters the working state through the self-check operation at startup, prevent the measurement failure or error increase caused by the faulty operation, and the self-check process can improve the operation safety and reliability of the equipment, reduce the risk of mismeasurement caused by hardware failure, and ensure the effectiveness of the subsequent calibration and sample detection process. By judging whether the self-check result meets the preset conditions, the equipment can be prevented from entering the calibration step if the self-check fails, avoiding the miscalibration operation under the fault state, thereby improving the working stability of the system. The calibration process can correct the characteristic parameters of each electrode before the instrument starts the sample detection, eliminate the deviation caused by electrode aging or external environment changes, and ensure the benchmark accuracy of the measurement. By judging whether the calibration result meets the preset conditions, it can be ensured that the sample detection is only performed when the calibration result is stable and accurate, thereby improving the accuracy of the sample analysis and avoiding the detection error caused by the calibration abnormality. The judgment of the calibration condition can reflect the working state of the electrode in the actual measurement to a certain extent, so that the initial detection result can be closer to the true characteristics of the sample. Correcting the initial detection result according to the calibration result can eliminate the measurement deviation caused by the electrode state fluctuation or the error during calibration, so that the target detection result is more accurate and stable. Through calibration operations, measurement errors caused by unstable electrode performance or improper maintenance can be reduced, and the consistency and reliability of measurements can be improved.

[0111] It should be noted that the modules and units in the control device of the electrolyte analyzer in this embodiment correspond one-to-one to the steps in the control method of the electrolyte analyzer in the aforementioned embodiment. Therefore, the specific implementation of this embodiment can refer to the implementation of the control method of the aforementioned electrolyte analyzer, which will not be repeated here.

[0112] Example 3

[0113] On the basis of Example 1, Example 3 of the present invention further provides an electrolyte analysis system, an electrolyte analyzer and a controller, wherein the controller controls the electrolyte analyzer by executing the control method of the electrolyte analyzer described in Example 1.

[0114] Specifically, the electrolyte analyzer is the hardware device that actually performs sample testing, including: Electrode module: used to detect the electrolyte ion concentration in the sample.

[0115] Liquid system: used for sample aspiration, reagent injection and waste liquid discharge.

[0116] Sensor module: monitors the working environment and reagent status.

[0117] Data acquisition module: real-time collection of potential, current and other signals of each electrode.

[0118] The controller communicates with the electrolyte analyzer in real time by sending instructions and receiving feedback, coordinating the operation of the entire detection process.

[0119] Example 3 is based on Example 1, and is expanded from a single control method to a complete system design. The electrolyte analyzer is combined with a controller, and an intelligent control method is used to realize automated, high-precision and high-stability electrolyte detection, which has a wide range of practical value and application prospects. The controller executes the automated control method, which can reduce the intervention of human operation and improve the convenience of operation. The application of dynamic correction factors and multi-stage calibration ensures the accuracy of the test results. The quality control management function can monitor the instrument status in real time, discover and handle problems in time, and ensure the long-term stable operation of the system.

[0120] Specifically, the processor may include a central processing unit (CPU), or an application specific integrated circuit (ASIC), or may be configured to implement one or more integrated circuits of the embodiment of the present invention.

[0121] The memory may include a large capacity memory for data or instructions. By way of example and not limitation, the memory may include a hard disk drive (HDD), a floppy disk drive, a flash memory, an optical disk, a magneto-optical disk, a magnetic tape, or a universal serial bus (USB) drive or a combination of two or more of these. Where appropriate, the memory may include a removable or non-removable (or fixed) medium. Where appropriate, the memory may be inside or outside the data processing device. In a particular embodiment, the memory is a non-volatile solid-state memory. In a particular embodiment, the memory includes a read-only memory (ROM). Where appropriate, the ROM may be a mask-programmed ROM, a programmable ROM (PROM), an erasable PROM (EPROM), an electrically erasable PROM (EEPROM), an electrically rewritable ROM (EAROM) or a flash memory or a combination of two or more of these.

[0122] The processor implements any one of the control methods of the electrolyte analyzer in the above embodiments by reading and executing computer program instructions stored in the memory.

[0123] Example 4

[0124] In addition, in combination with the control method of the electrolyte analyzer in the above embodiment, the embodiment of the present invention can provide a computer-readable storage medium for implementation. The computer-readable storage medium stores computer program instructions; when the computer program instructions are executed by the processor, any one of the control methods of the electrolyte analyzer in the above embodiment is implemented.

[0125] It should be clear that the present invention is not limited to the specific configuration and processing described above and shown in the figures. For the sake of simplicity, a detailed description of the known method is omitted here. In the above embodiments, several specific steps are described and shown as examples. However, the method process of the present invention is not limited to the specific steps described and shown, and those skilled in the art can make various changes, modifications and additions, or change the order between the steps, or perform several steps simultaneously after understanding the spirit of the present invention.

[0126] The above is only a specific implementation of the present invention. Those skilled in the art can clearly understand that for the convenience and simplicity of description, the specific working process of the system, module and unit described above can refer to the corresponding process in the aforementioned method embodiment, and will not be repeated here. It should be understood that the protection scope of the present invention is not limited to this. Any technician familiar with the technical field can easily think of various equivalent modifications or replacements within the technical scope disclosed by the present invention, and these modifications or replacements should be covered within the protection scope of the present invention.

Claims

1. A control method for an electrolyte analyzer, characterized in that: The method comprises: In response to a power-on instruction, controlling the electrolyte analyzer to perform a self-test to obtain a self-test result; In response to the self-test result satisfying a preset self-test condition, controlling the electrolyte analyzer to perform calibration according to a preset calibration rule to obtain a calibration result; In response to the calibration result satisfying a preset calibration condition, controlling the electrolyte analyzer to detect the sample to be tested to obtain an initial test result; The initial detection result is corrected according to the calibration result to obtain the target detection result of the sample to be tested.

2. The control method of the electrolyte analyzer according to claim 1, characterized in that: In response to the self-test result satisfying a preset self-test condition, controlling the electrolyte analyzer to perform calibration according to a preset calibration rule to obtain a calibration result, includes: Determine whether the displayed self-test result meets the preset self-test condition; If satisfied, obtaining a preset calibration cycle, wherein the preset calibration cycle includes several calibration stages; Alternately controlling the electrolyte analyzer to calibrate in each calibration stage by using a first calibration reagent and a second calibration reagent to obtain first calibration data; According to the CO2 standard reagent, controlling the electrolyte analyzer to perform TCO2 calibration to obtain second calibration data; The calibration result is obtained according to the first calibration data and the second calibration data.

3. The control method of the electrolyte analyzer according to claim 2, characterized in that: The method of alternately controlling the electrolyte analyzer to calibrate in each calibration stage by using the first calibration reagent and the second calibration reagent to obtain first calibration data includes: Controlling the electrolyte analyzer to perform calibration according to the first calibration reagent with a preset sample aspiration amount, and continuously collecting the voltage value of each electrode during the calibration stage; When the difference between two adjacent voltage values ​​collected at each electrode during the calibration phase is less than a preset voltage difference threshold or the duration of the calibration phase exceeds a preset waiting time, the electrolyte analyzer is controlled to be calibrated according to the preset sample aspiration amount of the second calibration reagent, and the voltage value of each electrode is continuously collected during the calibration phase; When the difference between two adjacent voltage values ​​collected at each of the electrodes in the calibration phase is less than a preset voltage difference threshold or the duration of the calibration phase exceeds a preset waiting time, return to control the electrolyte analyzer to calibrate according to the first calibration reagent with a preset sample aspiration amount, and continue to collect the voltage value of each electrode in the calibration phase until the preset calibration cycle ends, and obtain the first potential data of each electrode in each calibration phase; Obtaining the slope value of each electrode according to the first potential data and the Nernst equation in a specified calibration phase, wherein the specified calibration phase includes the second calibration phase and the fourth calibration phase in the preset calibration cycle; The first calibration data is obtained according to the first potential data of each electrode and the slope value in each calibration stage.

4. The control method of the electrolyte analyzer according to claim 2, characterized in that: In response to the calibration result satisfying the preset calibration condition, controlling the electrolyte analyzer to detect the sample to be tested to obtain an initial detection result, including: Determining whether the calibration result meets the preset calibration condition; If the conditions are met, the electrolyte analyzer is controlled to absorb the sample to be tested according to the preset sample adsorption amount, so that the sample to be tested completely covers the measurement area of ​​each electrode; Determining a signal acquisition time according to a sample type of the sample to be tested; Controlling each of the electrodes to analyze the sample to be tested according to the signal acquisition time to obtain an initial analysis result of each of the electrodes; The initial detection result is obtained according to the initial analysis result of each electrode.

5. The control method of the electrolyte analyzer according to any one of claims 2 to 4, characterized in that: The step of correcting the initial detection result according to the calibration result to obtain the target detection result of the sample to be tested includes: Acquire the potential data of the electrode at a preset time in the last calibration stage in the preset calibration cycle, and record it as first calibration data; Controlling the electrolyte analyzer to perform calibration according to the first calibration reagent to obtain potential data of each electrode at the preset time during the calibration process, which is recorded as second calibration data; Adjusting the slope value of each of the electrodes according to the difference between the first correction data and the second correction data; Correcting the initial analysis result of each electrode according to the adjusted slope value to obtain a first corrected analysis result; According to the preset extended Nernst equation, the first correction analysis result of the designated electrode is adjusted to obtain a second correction analysis result; A target detection result of the sample to be tested is obtained according to the first calibration analysis result and the second calibration analysis result.

6. The control method of the electrolyte analyzer according to claim 5, characterized in that: The designated electrode includes at least a lithium electrode and a magnesium electrode, and the first correction analysis result of the designated electrode is adjusted according to the preset extended Nernst equation to obtain the second correction analysis result, including: Obtaining an interfering ion corresponding to the lithium electrode as a first interfering ion, wherein the first interfering ion is a sodium ion; Obtaining an interfering ion corresponding to the magnesium electrode as a second interfering ion, wherein the second interfering ion is a calcium ion; According to the preset extended Nernst equation, the ion parameters of the first interfering ion and the second interfering ion, the first correction analysis result of each designated electrode is adjusted to obtain the corresponding second correction analysis result, wherein the ion parameters include activity and charge number, and the expression of the preset extended Nernst equation is: Where, E is the potential measurement value of the specified electrode, E 0 is the standard electrode potential, R is the gas constant, F is the Faraday constant, T is the absolute temperature, i is the ion to be measured, j is the interfering ion, a i and a j are the activities of the ion to be measured and the interfering ion, respectively, i is the charge number of the ion to be measured, z j is the charge number of the interfering ion, k ij is the selectivity coefficient between the ion to be measured and the interfering ion.

7. The control method of the electrolyte analyzer according to claim 6, characterized in that: The first correction analysis result of each designated electrode is adjusted according to the preset extended Nernst equation, the first interfering ion and the second interfering ion to obtain the corresponding second correction analysis result, including: Respectively dividing the concentration ranges of the first interfering ion and the second interfering ion to obtain a first concentration interval and a second concentration interval, wherein the first concentration interval and the second concentration interval both include a high concentration interval, a medium concentration interval, and a low concentration interval; For each of the first concentration intervals, a preset number of first mixed solutions are obtained, wherein the first mixed solutions include first interfering ions and corresponding ions to be detected, and different first mixed solutions have different concentration ratios of the first interfering ions and the corresponding ions to be detected; For each of the second concentration intervals, a preset number of second mixed solutions are obtained, wherein the second mixed solutions include second interfering ions and corresponding ions to be measured, and different second mixed solutions have different concentration ratios of the second interfering ions and the corresponding ions to be measured; Obtaining a first multi-point calibration data set corresponding to each of the first concentration intervals according to the potential values ​​of the lithium electrode in all the first mixed solutions; Obtaining a second multi-point calibration data set corresponding to each of the second concentration intervals according to the potential values ​​of the magnesium electrode in all the second mixed solutions; Fitting the first multi-point calibration data set and the second multi-point calibration data set by linear fitting or polynomial fitting to obtain a first functional relationship between the selectivity coefficient in different first concentration intervals and the concentration of the first interfering ion and a second functional relationship between the selectivity coefficient in different second concentration intervals and the concentration of the second interfering ion; According to the actual concentrations of the first interfering ion and the second interfering ion in the sample to be tested, obtaining the corresponding first selectivity coefficient and the second selectivity coefficient through the first functional relationship and the second functional relationship; According to the first selectivity coefficient, the second selectivity coefficient and the preset extended Nernst equation, the first correction analysis result of each designated electrode is adjusted respectively to obtain a corresponding second correction analysis result.

8. A control device for an electrolyte analyzer, characterized in that: The device comprises: A self-test module, used to control the electrolyte analyzer to perform self-test and obtain self-test results in response to a power-on instruction; A calibration module, configured to control the electrolyte analyzer to perform calibration to obtain a calibration result according to a preset calibration rule in response to the self-test result satisfying a preset self-test condition; A detection module, configured to control the electrolyte analyzer to detect the sample to be tested and obtain an initial detection result in response to the calibration result satisfying a preset calibration condition; The correction module is used to correct the initial detection result according to the calibration result to obtain the target detection result of the sample to be tested.

9. An electrolyte analysis system, characterized in that: include: An electrolyte analyzer and a controller, wherein the controller controls the electrolyte analyzer by executing the control method of the electrolyte analyzer according to any one of claims 1 to 7.

10. A storage medium having computer program instructions stored thereon, characterized in that: When the computer program instructions are executed by a processor, the method according to any one of claims 1 to 7 is implemented.

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