Artificial bone preparation method and artificial bone material

Abstract

The invention provides a preparation method of an artificial bone. The preparation method comprises the following steps: S1, synthesizing beta-tricalcium phosphate powder; s2, preparing an organic template, wherein the organic template is obtained by forming organic template particles in an organic template mold; s3, preparing artificial bone slurry, wherein the raw materials of the artificial bone slurry comprise beta-tricalcium phosphate powder, water, a dispersing agent and an adhesive; s4, grouting: grouting the artificial bone slurry into an artificial bone mold containing an organic template; s5, drying; and S6, sintering. By synthesizing the beta-tricalcium phosphate powder, the beta-tricalcium phosphate powder with fine crystal grains, good crystalline state and good dispersity can be obtained, so that the quality of the formed artificial bone is improved. The artificial bone is obtained through the preparation method, the artificial bone can be prepared in batches, and compared with an existing preparation technology, the production efficiency of the preparation method provided by the invention is obviously better.

Description

Technical Field

[0001] The present invention relates to the technical field of artificial bone preparation, in particular to an artificial bone preparation method and an artificial bone material. Background Art

[0002] Artificial bone is a biomaterial used to simulate the function of human bones. It can be used to repair, replace or strengthen damaged bones. There are many types of artificial bones, including metal bones, bioceramic bones, polymer bones, etc. Among them, bioceramic bones are widely studied and applied due to their excellent biocompatibility and osteoconductivity.

[0003] Bioceramic bone materials include hydroxyapatite and tricalcium phosphate, which have chemical compositions similar to human bones and have good biocompatibility and osteoinductivity.

[0004] The existing bioceramic bone preparation methods have low preparation efficiency and are difficult to produce bioceramic bones in large quantities. Summary of the invention

[0005] The purpose of the present invention is to provide an artificial bone preparation method and an artificial bone material to solve the problem that the preparation method has low preparation efficiency and is difficult to produce bioceramic bones in large quantities.

[0006] To achieve the above-mentioned purpose, the present invention provides the following technical scheme: an artificial bone preparation method, the preparation method comprising the following steps: S1, synthesizing β-tricalcium phosphate powder; S2, preparing an organic template, the organic template is obtained by molding organic template particles in an organic template mold; S3, preparing artificial bone slurry, the raw materials of the artificial bone slurry include: β-tricalcium phosphate powder, water, a dispersant and a binder; S4, grouting, pouring the artificial bone slurry into an artificial bone mold containing the organic template; S5, drying; S6, sintering.

[0007] Compared with the prior art, the preparation method of the present invention has the following beneficial effects: by synthesizing β-tricalcium phosphate powder, the present invention can obtain β-tricalcium phosphate powder with fine grains, good crystal state and good dispersibility, thereby improving the quality of the formed artificial bone. By obtaining artificial bone through the preparation method of the present invention, artificial bone can be prepared in batches. Compared with the existing preparation technology, the production efficiency of the preparation method provided by the present invention is significantly better.

[0008] Preferably, the above S1 specifically includes the following steps: weighing 3MOL of calcium chloride and 2MOL of diammonium hydrogen phosphate according to a calcium-phosphorus ratio of 1.5; dissolving the calcium chloride in 4L of ultrapure water, stirring and dissolving, and transferring to a reactor; dissolving diammonium hydrogen phosphate in 4L of ultrapure water, stirring and dissolving, and transferring to an upper dropping tank; slowly dropping the uniformly mixed diammonium hydrogen phosphate solution into the calcium chloride solution; stirring the reactor at a speed of 150 rpm; adjusting the pH to 6.5-7.2 with aqueous ammonia; until the diammonium hydrogen phosphate solution is completely added; after the addition is completed, continuing the reaction for 21 hours, and controlling the pH to 6.5-7.2; After aging for 20 hours, the liquid on the β-tricalcium phosphate powder is poured off after settling, and then washed with ultrapure water, and then washed with water for 3 times after settling. The washed powder is centrifuged, washed with water for 3 times, and then washed with ethanol for 3 times, and then thoroughly centrifuged until no liquid flows out; The centrifuged and cleaned β-tricalcium phosphate powder was transferred to a drying oven for drying at a temperature of 80°C for 24 hours. After drying, the β-tricalcium phosphate powder was transferred to a muffle furnace for sintering to obtain β-TCP powder, which was then ground and sieved (300 mesh).

[0009] Preferably, the sintering method is to raise the temperature to 800° C. within 240 minutes and keep the temperature for 2 hours.

[0010] Preferably, the above S2 specifically includes the following steps: adding organic template particles into an organic template mold, placing a gasket on the bottom surface of the organic template mold, adding 75% concentration acetone solvent, soaking for 3-4 minutes, turning on the air pump to drain the acetone solvent in the organic template mold, adding purified water to clean the acetone, using a push rod to push the organic template out of the organic template mold, soaking the organic template in purified water for 5 minutes, taking out the organic template and putting it in an oven for drying, the drying temperature is 60 degrees and lasts for 2 hours.

[0011] Preferably, the organic template particles are PMMA particles, and the particle size of the organic template particles is 500 μm.

[0012] Preferably, the above S3 specifically includes the following steps: adding water accounting for 29%wt of the total mass of artificial bone paste, dispersant accounting for 1%wt of the total mass of artificial bone paste and β-tricalcium phosphate powder accounting for 65%wt of the total mass of artificial bone paste in sequence, then adding a mill, covering and tightening the nut to fix it; putting it into the mill and grinding it for 2 hours; after stopping the machine and opening the cover, check the tank to confirm that it has become a slurry, and add an adhesive accounting for 5%wt of the total mass of the artificial bone paste according to the process parameters; putting it into a mixer and stirring it for 10 minutes.

[0013] Preferably, the above S4 specifically includes the following steps: Place the prepared organic template neatly in the artificial bone mold, pour the slurry on the surface of the organic template, and always keep the slurry submerged in the organic template; wait for the slurry to penetrate into the organic template and fill the organic template, ensure that the dried slurry solid phase finally fills the organic template, the grouting is completed, and the slurry is naturally and completely dry.

[0014] Preferably, in the above S5, the drying temperature is 50 degrees and the drying time is 24 hours.

[0015] Preferably, the above S6 specifically includes the following steps: S61, the temperature increases at a rate of 1°C / min; S62, temperature rises to 220℃, keep warm for 12 hours S63, the temperature increases at a rate of 1°C / min; S64, the temperature is raised to 260°C and kept at this temperature for 6 hours; S65, the temperature increases at a rate of 1°C / min; S66, the temperature is raised to 290°C and kept for 3 hours; S67, the temperature increases at a rate of 3°C / min; S68, the temperature is raised to 1100°C and kept at this temperature for 3 hours; S69, cooling (cooling with the furnace).

[0016] Based on another purpose of the present invention, the present invention provides the following technical solution: an artificial bone material, the artificial bone material is the β-tricalcium phosphate powder in the above-mentioned artificial bone preparation method, and the β-tricalcium phosphate powder includes the following raw materials: diammonium hydrogen phosphate, calcium chloride, ammonia water, purified water, and ethanol. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the provided drawings without paying creative work.

[0018] Figure 1 A technical roadmap for an artificial bone preparation method; Figure 2 is the X-ray diffraction pattern of β-tricalcium phosphate; Figure 3 Schematic diagram of the three-dimensional structure of the organic template mold; Figure 4 is a cross-sectional view of an organic template mold; Figure 5 for Figure 4 A partial enlarged view of point A in the middle.

[0019] In the figure: base 1, sealing strip 2, air hole 3, organic template 4, uniform cross-section cavity 5, ejector rod 6, handle 7, guide hole 8, guide plate 9, molding main board 11, gasket 12, air hole bottom plate 13, installation space 14, positioning part 15. DETAILED DESCRIPTION

[0020] In order to enable those skilled in the art to better understand the solution of the present invention, the present invention is further described in detail below in conjunction with the accompanying drawings and specific implementation methods.

[0021] In this article, the terms "upper, lower, inside, outside" and the like are established based on the positional relationships shown in the drawings. The corresponding positional relationships may also change depending on the drawings, and therefore cannot be understood as absolute limitations on the scope of protection; moreover, relational terms such as "first" and "second" and the like are merely used to distinguish one component from another with the same name, and do not necessarily require or imply any actual relationship or order between these components.

[0022] Embodiment 1 like Figure 1 As shown, this embodiment provides an artificial bone preparation method, and the preparation method includes the following steps: S1, synthesizing β-tricalcium phosphate powder; S2, preparing an organic template, which is obtained by molding organic template particles in an organic template mold; S3, preparing artificial bone slurry, and the raw materials of the artificial bone slurry include: β-tricalcium phosphate powder, water, a dispersant and a binder; S4, grouting, pouring the artificial bone slurry into an artificial bone mold containing the organic template; S5, drying; S6, sintering.

[0023] Specifically, by synthesizing β-tricalcium phosphate powder, this embodiment can obtain β-tricalcium phosphate powder with fine grains, good crystal state and good dispersibility, thereby improving the quality of the formed artificial bone. By obtaining artificial bone through the preparation method of this embodiment, artificial bone can be prepared in batches. Compared with the existing preparation technology, the production efficiency of the preparation method provided by this embodiment is significantly better.

[0024] Furthermore, the above S1 specifically includes the following steps: weighing 3MOL of calcium chloride and 2MOL of diammonium hydrogen phosphate according to a calcium-phosphorus ratio of 1.5; dissolving the calcium chloride in 4L of ultrapure water, stirring and dissolving, and transferring to a reactor; dissolving diammonium hydrogen phosphate in 4L of ultrapure water, stirring and dissolving, and transferring to an upper dropping tank; slowly dropping the uniformly mixed diammonium hydrogen phosphate solution into the calcium chloride solution; stirring the reactor at a speed of 150 rpm; adjusting the pH to 6.5-7.2 with ammonia water; until the diammonium hydrogen phosphate solution is added dropwise; after the addition is completed, continuing the reaction for 21 hours, and controlling the pH to 6.5-7.2; The aging treatment is carried out for 20 hours. The aging treatment is carried out in a sealed container for 20 hours. After the β-tricalcium phosphate powder settles, the liquid on the surface is poured out, and then ultrapure water is added for washing. The powder is washed with water for three times after sedimentation. The washed powder is centrifuged, washed with water three times and then with ethanol three times, and thoroughly centrifuged until no liquid flows out. The centrifuged and cleaned β-tricalcium phosphate powder was transferred to a drying oven for drying at 80°C for 24 hours. After drying, the β-tricalcium phosphate powder was transferred to a muffle furnace for sintering. The sintering method was to heat the powder to 800°C in 240 minutes and keep the temperature for 2 hours. After sintering, the β-TCP powder was obtained and then ground and sieved (300 mesh).

[0025] Further, the above S2 specifically includes the following steps: adding organic template particles to an organic template mold, placing a gasket on the bottom surface of the organic template mold, adding 75% acetone solvent, soaking for 3 to 4 minutes, turning on the air pump to drain the acetone solvent in the organic template mold, adding purified water to clean the acetone, using a push rod to push the organic template out of the organic template mold, soaking the organic template in purified water for 5 minutes, taking out the organic template and putting it in an oven for drying, the drying temperature is 60 degrees and lasts for 2 hours. Further, the organic template particles are PMMA particles, and the particle size of the organic template particles is 500μm.

[0026] Specifically, Figure 3-5 As shown, this embodiment provides an organic template mold, including: a base 1, in which an installation space 14 is provided; a pore 3 bottom plate, in which the pore 3 bottom plate is installed on the base 1, and the pore 3 bottom plate is provided with a plurality of pores 3; a gasket 12, in which the gasket 12 is placed on the pore 3 bottom plate and covers the plurality of pores 3; a molding main board 11, in which a plurality of equal-section mold cavities 5 are provided, and the upper and lower ends of the equal-section mold cavities 5 are both open. In the process of preparing the organic template 4, the pore 3 bottom plate is directly installed into the base 1. The gasket 12 is laid flat on the pores 3. When laying the gasket 12 flat, it should be noted that the gasket 12 must cover all the pores 3. After laying the gasket 12, the molding main board 11 is pressed into the base 1. During installation, the molding main board 11 and the gasket 12 should be tightly attached to each other without leaking. Add the organic template 4 particles into the equal-section mold cavity 5 of the molding main board 11 without overflowing. Add the solvent acetone, and after the organic template 4 in the uniform cross-section mold cavity 5 is formed, remove the mold main board 11 and remove the gasket 12, then reinstall the mold main board 11 into the base 1, open the negative pressure on the bottom plate of the air hole 3, drain the acetone, and add purified water to clean the organic template 4. After cleaning, the organic template 4 can be obtained from the uniform cross-section mold cavity 5. Through the above steps, a batch of organic templates 4 can be easily obtained.

[0027] Preferably, it also includes: a sealing strip 2, and a sealing strip 2 is provided between the bottom plate of the air hole 3 and the base 1. The sealing strip 2 is first installed on the bottom plate of the air hole 3, and then the bottom plate of the air hole 3 with the sealing strip 2 is directly installed into the base 1. The sealing is ensured and the suction effect is improved when the bottom plate of the air hole 3 is opened to generate negative pressure.

[0028] Preferably, it also includes: a guide plate 9, which is provided with guide holes 8 adapted to a plurality of equal-section mold cavities 5; and a push rod 6, which is adapted to the guide holes 8. The guide holes 8 are also through holes, which penetrate the guide plate 9 along the height of the guide plate 9. After the organic template 4 is cleaned, the molding main board 11 is removed, the guide plate 9 is installed directly above the molding main board 11, and the guide holes 8 are aligned with the equal-section mold cavities 5 of the molding main board 11, and the organic template 4 in the equal-section mold cavities 5 is ejected with the push rod 6. The arrangement of the guide plate 9 and the push rod 6 makes it easier to eject the organic template 4.

[0029] Preferably, it further comprises: a positioning portion 15, which is arranged at both ends of the mold main board 11, and the guide plate 9 is placed on the positioning portion 15. The positioning portion 15 is a stepped square groove, and the shape and size of the positioning portion 15 just match the guide plate 9, that is, the guide plate 9 can just fit into the positioning portion 15. When the guide plate 9 is placed in the positioning portion 15, the guide hole 8 of the guide plate 9 is aligned with the uniform cross-section mold cavity 5 of the mold main board 11. By providing the positioning portion 15, the uniform cross-section mold cavity 5 can be aligned with the guide hole 8 more conveniently.

[0030] Preferably, it also includes a handheld portion 7, which is connected to the ejector rod 6 and has anti-slip patterns. In order to facilitate ejection of the organic template 4 by the ejector rod 6, the handheld portion 7 is specially provided to facilitate the relevant staff to hold it. Of course, the handheld portion 7 can also be connected to a power source to realize automatic ejection of the organic template 4.

[0031] Preferably, the cross section of the uniform cross-section mold cavity 5 is rectangular; or, the cross section of the uniform cross-section mold cavity 5 is arc-shaped; or, the cross section of the uniform cross-section mold cavity 5 is elliptical; or, the cross section of the uniform cross-section mold cavity 5 is trapezoidal. The specific cross section of the uniform cross-section mold cavity 5 is not limited here, and can be selected according to actual conditions. Preferably, the cross section of the uniform cross-section mold cavity 5 is rectangular.

[0032] Preferably, the base 1 is overfitted with the mold main board 11. The mold main board 11 needs to be pressed into the base 1 by external force, and after being pressed in, the position of the mold main board 11 will not change easily.

[0033] Preferably, the bottom plate of the air hole 3 is connected to an air pump to provide suction force.

[0034] Furthermore, the above S3 specifically includes the following steps: adding water accounting for 29%wt of the total mass of artificial bone slurry, dispersant accounting for 1%wt of the total mass of artificial bone slurry and β-tricalcium phosphate powder accounting for 65%wt of the total mass of artificial bone slurry in sequence, and then adding a mill, covering and tightening the nut to fix it; putting it into the mill and grinding it for 2 hours; after stopping the machine and opening the cover, check the tank to confirm that it has become a slurry, and add an adhesive accounting for 5%wt of the total mass of the artificial bone slurry according to the process parameters; putting it into a mixer and stirring for 10 minutes.

[0035] Furthermore, the above S4 specifically includes the following steps: Place the prepared organic template neatly in the artificial bone mold, pour the slurry on the surface of the organic template, and always keep the slurry submerged in the organic template; wait for the slurry to penetrate into the organic template and fill the organic template, ensure that the dried slurry solid phase finally fills the organic template, the grouting is completed, and the slurry is naturally and completely dry.

[0036] Furthermore, in the above S5, the drying temperature is 50 degrees and the drying time is 24 hours.

[0037] Furthermore, the above S6 specifically includes the following steps: S61, the temperature increases at a rate of 1°C / min; S62, temperature rises to 220℃, keep warm for 12 hours S63, the temperature increases at a rate of 1°C / min; S64, the temperature is raised to 260°C and kept at this temperature for 6 hours; S65, the temperature increases at a rate of 1°C / min; S66, the temperature is raised to 290°C and kept for 3 hours; S67, the temperature increases at a rate of 3°C / min; S68, the temperature is raised to 1100°C and kept at this temperature for 3 hours; S69, cooling (cooling with the furnace).

[0038] Embodiment 2 The same parts in this embodiment as those in the first embodiment are given the same figure marks, and the same text descriptions are omitted.

[0039] This embodiment discloses an artificial bone material, which is the β-tricalcium phosphate powder in the artificial bone preparation method of embodiment 1, and the β-tricalcium phosphate powder includes the following raw materials: diammonium hydrogen phosphate, calcium chloride, ammonia water, purified water, and ethanol. The specific preparation steps of the β-tricalcium phosphate powder are as follows: weigh 3MOL of calcium chloride and 2MOL of diammonium hydrogen phosphate according to a calcium-phosphorus ratio of 1.5; dissolve the calcium chloride in 4L ultrapure water, stir and dissolve, and transfer to a reactor; dissolve the diammonium hydrogen phosphate in 4L ultrapure water, stir and dissolve, and transfer to the upper dropping tank; slowly drip the uniformly mixed diammonium hydrogen phosphate solution into the calcium chloride solution; stir the reactor at a speed of 150 rpm; adjust the pH to 6.5-7.2 with ammonia water; until the diammonium hydrogen phosphate solution is dripped; after the dripping is completed, continue the reaction for 21 hours, and control the pH to 6.5-7. 2. Aging treatment for 20 hours. To prevent aging treatment, place the β-tricalcium phosphate powder in a sealed container for 20 hours. After the β-tricalcium phosphate powder settles, pour out the liquid on it, add ultrapure water to wash, settle and wash with water 3 times, centrifuge the washed powder, wash with water three times and then with ethanol three times, and centrifuge thoroughly until no liquid flows out; transfer the centrifuged and washed β-tricalcium phosphate powder to a drying oven for drying at 80°C for 24 hours; after drying, transfer the β-tricalcium phosphate powder to a muffle furnace for sintering. The sintering method is to heat up to 800°C in 240 minutes and keep warm for 2 hours. After sintering, the β-TCP powder is obtained and then ground and sieved (300 mesh). Figure 2 As shown, the diffraction peak of the β-tricalcium phosphate powder prepared in this embodiment becomes narrow, sharp and strong, indicating that the material has a good degree of crystallization, and the three main peaks are consistent with the standard spectrum, and no miscellaneous items appear. This shows that the β-tricalcium phosphate powder prepared by the sufficient reaction of calcium chloride and diammonium hydrogen phosphate has a high purity.

[0040] Preferably, the content of β-tricalcium phosphate in β-tricalcium phosphate powder is not less than 95%. The content of trace elements in β-tricalcium phosphate powder should meet the following requirements: maximum content of arsenic (As) 3 (ug / g), maximum content of cadmium (Cd) 5 (ug / g), maximum content of mercury (Hg) 5 (ug / g), maximum content of lead (Pb) 30 (ug / g), and total amount of heavy metals (in terms of Pb) 50 (ug / g).

[0041] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

Claims

1. A method for preparing an artificial bone, characterized in that: The preparation method comprises the following steps: S1, synthetic β-tricalcium phosphate powder; S2, preparing an organic template, wherein the organic template is obtained by molding organic template particles in an organic template mold; S3, preparing artificial bone paste, wherein the raw materials of the artificial bone paste include: β-tricalcium phosphate powder, water, a dispersant and a binder; S4, grouting, pouring the artificial bone slurry into the artificial bone mold containing the organic template; S5, drying; S6. Sintering.

2. The method for preparing an artificial bone according to claim 1, characterized in that: The above S1 specifically includes the following steps: weighing 3MOL of calcium chloride and 2MOL of diammonium hydrogen phosphate according to a calcium-phosphorus ratio of 1.5; dissolving the calcium chloride in 4L of ultrapure water, stirring and dissolving, and transferring to a reactor; dissolving diammonium hydrogen phosphate in 4L of ultrapure water, stirring and dissolving, and transferring to the upper dropping tank; slowly dropping the uniformly mixed diammonium hydrogen phosphate solution into the calcium chloride solution; stirring the reactor at a speed of 150 rpm; adjusting the pH to 6.5-7.2 with ammonia water; until the diammonium hydrogen phosphate solution is added dropwise; after the addition is completed, continuing the reaction for 21 hours, and controlling the pH to 6.5-7.2; After aging for 20 hours, the liquid on the β-tricalcium phosphate powder is poured off after settling, and then washed with ultrapure water, and then washed with water for 3 times after settling. The washed powder is centrifuged, washed with water for 3 times, and then washed with ethanol for 3 times, and then thoroughly centrifuged until no liquid flows out; The centrifuged and cleaned β-tricalcium phosphate powder was transferred to a drying oven for drying at a temperature of 80°C for 24 hours. After drying, the β-tricalcium phosphate powder was transferred to a muffle furnace for sintering to obtain β-TCP powder, which was then ground and sieved (300 mesh).

3. The method for preparing an artificial bone according to claim 2, characterized in that: The sintering method is to raise the temperature to 800°C in 240 minutes and keep the temperature for 2 hours.

4. The method for preparing an artificial bone according to claim 1, characterized in that: The above S2 specifically includes the following steps: adding organic template particles into an organic template mold, placing a gasket on the bottom surface of the organic template mold, adding 75% concentration acetone solvent, soaking for 3 to 4 minutes, turning on the air pump to drain the acetone solvent in the organic template mold, adding purified water to clean the acetone, using a push rod to push the organic template out of the organic template mold, soaking the organic template in purified water for 5 minutes, taking out the organic template and putting it in an oven for drying, the drying temperature is 60 degrees and lasts for 2 hours.

5. The method for preparing an artificial bone according to claim 4, characterized in that: The organic template particles are PMMA particles, and the particle size of the organic template particles is 500 μm.

6. The method for preparing an artificial bone according to claim 1, characterized in that: The above S3 specifically includes the following steps: adding water accounting for 29%wt of the total mass of artificial bone paste, dispersant accounting for 1%wt of the total mass of artificial bone paste and β-tricalcium phosphate powder accounting for 65%wt of the total mass of artificial bone paste in sequence, then adding a mill, covering and tightening the nut to fix; putting it into the mill and grinding it for 2 hours; after stopping the machine and opening the cover, check the tank to confirm that it has become a slurry, and add an adhesive accounting for 5%wt of the total mass of artificial bone paste according to the process parameters; putting it into a mixer and stirring for 10 minutes.

7. The method for preparing an artificial bone according to claim 1, characterized in that: The above S4 specifically includes the following steps: Place the prepared organic template neatly in the artificial bone mold, pour the slurry on the surface of the organic template, and always keep the slurry submerged in the organic template; wait for the slurry to penetrate into the organic template and fill the organic template, ensure that the dried slurry solid phase finally fills the organic template, the grouting is completed, and the slurry is naturally and completely dry.

8. The method for preparing an artificial bone according to claim 1, characterized in that: In the above S5, the drying temperature is 50 degrees and the drying time is 24 hours.

9. The method for preparing an artificial bone according to claim 1, characterized in that: The above S6 specifically includes the following steps: S61, the temperature increases at a rate of 1°C / min; S62, temperature rises to 220℃, keep warm for 12 hours S63, the temperature increases at a rate of 1°C / min; S64, the temperature is raised to 260°C and kept at this temperature for 6 hours; S65, the temperature increases at a rate of 1°C / min; S66, the temperature is raised to 290°C and kept for 3 hours; S67, the temperature increases at a rate of 3°C / min; S68, the temperature is raised to 1100°C and kept at this temperature for 3 hours; S69, cooling (cooling with the furnace).

10. An artificial bone material, which is the β-tricalcium phosphate powder in the artificial bone preparation method according to any one of claims 1 to 9, characterized in that: β-tricalcium phosphate powder includes the following raw materials: diammonium hydrogen phosphate, calcium chloride, ammonia water, purified water, and ethanol.

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