Anti-allergic paste as well as preparation method and application thereof

Abstract

The invention provides an anti-allergic ointment and a preparation method and application thereof, and belongs to the technical field of medicinal ointments, the anti-allergic ointment comprises a carrier and an ointment body; the carrier is prepared from the following components in percentage by mass: 41 to 44 percent of grease, 21 to 23 percent of hydrogel, 13 to 14 percent of fatty alcohol, 4 to 5 percent of emulsifier, 12 to 13 percent of thermosensitive hydroxypropyl methyl cellulose and the balance of water; the ointment body is prepared from the following components in parts by weight: 5 to 7 parts of artocarpus nanchuanensis, 4 to 5 parts of radix scutellariae, 2 to 3 parts of cortex phellodendri, 0.3 to 0.5 part of honeysuckle flower-fructus gardeniae-herba portulacae water vapor extract, 2 to 3 parts of fructus forsythiae, 0.7 to 0.9 part of radix sophorae flavescentis, 0.5 to 0.8 part of cortex dictamni, 0.5 to 0.8 part of fructus kochiae and 5 to 6 parts of blumea oil. The traditional Chinese medicine composition improves the curative effect and reduces side effects.

Description

Technical Field

[0001] The invention belongs to the technical field of pharmaceutical ointments, and in particular relates to an anti-allergic ointment and a preparation method and application thereof. Background Art

[0002] Local skin allergy refers to the allergic reaction of the skin to certain substances, usually manifested as local skin redness, itching, swelling, rash and other symptoms. There are many reasons, such as contact with allergens, cosmetics, detergents, metals, etc.; food allergies, such as seafood, milk, eggs, etc.; drug allergies, such as antibiotics, non-steroidal anti-inflammatory drugs, etc.; environmental factors, such as climate change, ultraviolet rays, etc. The current common treatment methods are: avoid contact with allergens, that is, find out the cause of the allergy and try to avoid contact; local cold compress, that is, use ice packs or wet towels to cool the affected area, which helps relieve itching and swelling; moisturizing, that is, use mild moisturizing creams or lotions to keep the skin moist to help relieve symptoms; drug treatment, that is, use anti-allergic drugs, such as antihistamines (loratadine, chlorpheniramine, etc.) or topical hormone ointments (hydrocortisone cream, dexamethasone acetate ointment, etc.).

[0003] The above-mentioned commonly used anti-allergic drugs are all Western medicines, mainly used to treat allergic reactions, such as local skin allergy symptoms. Although antihistamines (loratadine, chlorpheniramine, etc.) can relieve allergic symptoms, such as redness, itching and swelling, these drugs are usually divided into three generations, each with its own specific side effects. Hormone ointments (hydrocortisone cream and dexamethasone acetate ointment) contain hormone ingredients, which can quickly relieve inflammation and allergic reactions. However, long-term use or large-area use may cause side effects such as thinning of the skin and pigmentation, and rebound phenomenon is prone to occur after discontinuation of the drug, that is, the symptoms worsen. Summary of the invention

[0004] In order to solve the problems existing in the background technology, the present invention provides an anti-allergic paste and a preparation method and application thereof, which can improve the efficacy and reduce the side effects.

[0005] In order to achieve the above-mentioned object, in a first aspect, the present invention provides an anti-allergic paste, comprising a carrier and a paste body;

[0006] The carrier comprises the following components by mass percentage: 41-44% of oil, 21-23% of hydrogel, 13-14% of fatty alcohol, 4-5% of emulsifier, 12-13% of thermosensitive hydroxypropyl methylcellulose and the balance of water;

[0007] The paste body comprises the following components by weight: 5-7 parts of Artocarpus nanchuanensis, 4-5 parts of Scutellaria baicalensis, 2-3 parts of Phellodendron amurense, 0.3-0.5 parts of honeysuckle-gardenia-portulaca oleracea steam extract, 2-3 parts of Forsythia suspensa, 0.7-0.9 parts of Sophora flavescens, 0.5-0.8 parts of Dictamni cortex, 0.5-0.8 parts of Kochia scoparia and 5-6 parts of Artemisia argyi oil.

[0008] Furthermore, the preparation method of the thermosensitive hydroxypropyl methylcellulose is as follows:

[0009] A1. Mix equal amounts of a 7-9% hydroxypropyl methylcellulose aqueous solution and a 7-9% poly (N-isopropylacrylamide) aqueous solution to obtain a mixed solution;

[0010] A2, treat the mixture obtained in A1 in a fume hood at 60-70°C until a viscous gel-like substance is formed;

[0011] A3. Transfer the gel-like substance obtained in A2 to an oven, dry it at 85-90°C for 3-5 hours, take it out, grind it into powder, and obtain thermosensitive hydroxypropyl methylcellulose.

[0012] Furthermore, the oil comprises one of white vaseline, liquid paraffin, and lanolin, or a mixture of at least two of them.

[0013] Furthermore, the hydrogel is carbomer.

[0014] Furthermore, the fatty alcohol includes stearyl alcohol or cetyl alcohol.

[0015] Furthermore, the emulsifier includes polysorbate or Span.

[0016] Furthermore, the preparation method of the honeysuckle-gardenia-purslane water vapor extract is as follows:

[0017] A1. Weigh honeysuckle, gardenia and purslane in a mass ratio of 1: (1-1.2): (1.3-1.5), mix to obtain a raw material, add 3-4 times the weight of the raw materials in 65-70° C. water, soak for 1-2 hours, and obtain an soaked material;

[0018] A2, add 7-8 times the total weight of water of the raw materials to the soaked material obtained in A1, and distill and reflux for 10-12 hours to obtain a feed liquid;

[0019] A3. Concentrate the liquid obtained in A2 to 3-3.5 times the total weight of the raw materials, let it stand for 8-12 hours to precipitate, take the supernatant and concentrate it under reduced pressure to a relative density of 1.17 at 60°C, spray dry, collect powder, and grind to obtain the honeysuckle-gardenia-purslane steam extract.

[0020] In a second aspect, the present invention provides a method for preparing the above-mentioned anti-allergic paste, comprising the following steps:

[0021] S1. preparing a carrier;

[0022] Heat and melt the oil, mix the hydrogel and water, add fatty alcohol after the two are mixed, add emulsifier while stirring continuously, then add heat-sensitive hydroxypropyl methylcellulose, transfer to a high-speed homogenizer for homogenization, and naturally cool to room temperature to obtain a carrier;

[0023] S2, preparing the paste body;

[0024] Crush Artocarpus nanchuanensis, Scutellaria baicalensis, Phellodendron amurense, Fructus Forsythiae, Sophora flavescens, Dictamni cortex and Kochia scoparia to obtain a mixed fine material; evenly mix the mixed fine material with honeysuckle-gardenia-purslane steam extract, add wormwood oil, and continue stirring to mix well to obtain the paste body.

[0025] Furthermore, in S1, the speed of the high-speed homogenizer is 5000-6000 r / min, the temperature is 28-30° C., and the processing time is 1-1.5 h.

[0026] In a third aspect, the present invention provides an application of the above-mentioned anti-allergic cream, wherein the carrier is first applied to the affected area of ​​the skin and its surrounding area, and then pressed clockwise for 3-5 minutes to form a carrier layer, and then the cream body is applied on the carrier layer.

[0027] This application has the following beneficial effects:

[0028] 1. The anti-allergic paste of the present invention comprises a carrier and a paste body. The paste body is a pure herbal (traditional Chinese medicine) ingredient, has no side effects, and has good anti-allergic / antipruritic effects. The carrier can assist in the sustained release of the effective therapeutic ingredients of the paste body, ensure that the therapeutic effect is long-lasting and reliable, and thus improve the anti-allergic / antipruritic effects. Moreover, it has been verified by experiments that the addition of thermosensitive hydroxypropyl methylcellulose in the preparation of the carrier of the present invention and the addition of honeysuckle-gardenia-portulaca water vapor extract in the preparation of the paste body of the present invention have a synergistic effect, which can synergistically improve the anti-allergic / antipruritic effects of the anti-allergic paste of the present invention.

[0029] 2. In the preparation of the carrier of the present invention, oil can form a protective film on the skin surface, which is helpful for the slow release of the drug components in the paste body; hydrogel can absorb and retain water, thereby helping the gradual release of the drug components; fatty alcohol can form a stable oil-water mixture to maintain the sustained-release balance of different drug components; emulsifiers are beneficial to the mutual dissolution of oil and water on the one hand, and can help the drug components to form a stable state between oil and water on the other hand, thereby prolonging the stable residence time of the drug on the skin; thermosensitive hydroxypropyl methylcellulose is more sensitive to the body temperature of mice / humans. After being applied to the skin surface, it is beneficial to more accurately screen the relevant drug components and control their sustained-release speed and effect, which is beneficial to improve the efficacy of the drug and reduce side effects.

[0030] 3. In the preparation of thermosensitive hydroxypropyl methylcellulose, hydroxypropyl methylcellulose is a water-soluble polymer, and poly (N-isopropylacrylamide) is a temperature-sensitive polymer, which has unique temperature responsiveness in a water environment. When the temperature is higher than its lower critical solution temperature (about 32°C), it will undergo a phase transition from hydrophilic to hydrophobic. This also makes the thermosensitive hydroxypropyl methylcellulose prepared in the present invention have this thermosensitive ability, so that when the thermosensitive hydroxypropyl methylcellulose of the present invention is applied to the skin of mice / human beings, a phase change occurs due to body temperature, thereby more accurately screening and controlling the sustained release rate and effect of the honeysuckle-gardenia-purslane water vapor extract, so as to synergistically improve the anti-allergic / antipruritic effect of the anti-allergic cream of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 , a comparative trend chart of the anti-allergic / antipruritic effect test data of the products obtained from Examples 1-7 of the present invention and Comparative Examples 1-7. DETAILED DESCRIPTION

[0032] The present application is further described in detail below with reference to the embodiments.

[0033] Unless otherwise specified, the raw materials used in the examples and comparative examples of the present application are all commercially available.

[0034] Example 1: (1) Preparation of heat-sensitive hydroxypropyl methylcellulose, the preparation method is as follows:

[0035] A1. Mix equal amounts of 8% hydroxypropyl methylcellulose aqueous solution and poly (N-isopropylacrylamide) aqueous solution, and stir at 250 r / min for 20 min to achieve a uniform mixing effect to obtain a mixed solution.

[0036] A2. Stir the mixture obtained in A1 in a fume hood at 68°C at a stirring speed of 200 r / min to allow the water to evaporate slowly until a viscous gel-like substance is formed; the whole process takes 11.5 hours.

[0037] A3. Transfer the gel-like substance obtained in A2 to an oven, dry it at 86°C for 4 hours, take it out, grind it into powder, and obtain thermosensitive hydroxypropyl methylcellulose.

[0038] (2) Prepare the carrier, and the preparation method thereof is as follows:

[0039] Calculate the components by mass percentage: 42% oil, 22% hydrogel, 13.5% fatty alcohol, 4.5% emulsifier, 12.5% ​​thermosensitive hydroxypropyl methylcellulose and 5.5% water.

[0040] Heat and melt the oil, mix the hydrogel with water, add the fatty alcohol after the two are mixed, add the emulsifier while stirring at a stirring speed of 280r / min, then add the thermosensitive hydroxypropyl methylcellulose, continue stirring at a stirring speed of 280r / min for 20min, and then transfer to a high-speed homogenizer for homogenization. The speed of the high-speed homogenizer is 5500r / min, the temperature is 30°C, and the processing time is 1.2h. Then, take it out and place it in a container, and cool it naturally to room temperature to obtain the carrier.

[0041] The oil is white vaseline, the hydrogel is carbomer, the fatty alcohol is stearyl alcohol, and the emulsifier is polysorbate.

[0042] White vaseline (petroleum grease-vaseline, oil content 70%), purchased from Shanghai Yuejiang Titanium Dioxide Chemical Products Co., Ltd. Carbomer (model 676, content ≥99%, brand American Lubrizol), purchased from Guangzhou Gongying Chemical Co., Ltd. Stearyl alcohol is specifically 1618 alcohol (cetostearyl alcohol), purchased from Guangzhou Bolu Chemical Co., Ltd. Polysorbate (Tween 80, premium grade) was purchased from Hai'an Petrochemical Plant in Jiangsu Province.

[0043] (3) Preparation of honeysuckle-gardenia-purslane steam extract, the preparation method is as follows:

[0044] A1. Weigh honeysuckle, gardenia and purslane in a mass ratio of 1:1:1, mix to obtain a raw material, add 68°C water 3 times their weight, soak for 1.5 hours, and obtain an soaked material.

[0045] A2. Add 7 times the total weight of water to the soaked material obtained in A1, and distill and reflux for 11 hours to obtain a feed solution.

[0046] A3. Concentrate the liquid obtained in A2 to 3 times the total weight of the raw materials, let it stand for 10 hours to precipitate, take the supernatant and concentrate it under reduced pressure to a relative density of 1.17 at 60°C, spray dry, collect powder, and grind to obtain the honeysuckle-gardenia-purslane steam extract.

[0047] (4) Prepare the paste body, the preparation method is as follows:

[0048] The components were weighed in parts by weight: 6 parts of Artocarpus nanchuanensis, 4.5 parts of Scutellaria baicalensis, 2.5 parts of Phellodendron amurense, 0.4 parts of honeysuckle-gardenia-portulaca oleracea steam extract, 2.5 parts of Forsythia suspensa, 0.8 parts of Sophora flavescens, 0.7 parts of Dictamni cortex, 0.6 parts of Kochia scoparia and 5.5 parts of Artemisia argyi oil.

[0049] Crush Artocarpus nanchuanensis, Scutellaria baicalensis, Phellodendron amurense, Forsythia suspensa, Sophora flavescens, Dictamni cortex and Kochia scoparia to obtain a mixed fine material; mix the mixed fine material with the honeysuckle-gardenia-portulaca water vapor extract, stir at a stirring speed of 200 r / min for 30 minutes until the mixture is uniform, add wormwood oil, and continue stirring at a stirring speed of 300 r / min for 30 minutes to mix well, to obtain the paste body.

[0050] Among them, Artocarpus nanchuanensis is fresh meat without core and baked until the water content reaches about 10%. Scutellaria baicalensis, Phellodendron chinense, Forsythia suspensa, Sophora flavescens, Dictamni cortex and Kochia scoparia are all commercially available dry medicinal materials.

[0051] (5) Application of anti-allergic cream: Specific steps: first apply the carrier evenly to the affected area and surrounding areas. The dosage is calculated based on the skin area, about 0.3g / cm 2 , rotate clockwise and press for 3 minutes to form a carrier layer on the skin. Then, apply the cream evenly on the carrier layer. The amount is calculated based on the skin area, about 0.6g / cm 2 That is, the amount of the ointment body is about twice that of the carrier. After rotating counterclockwise and pressing for 1 minute, an ointment layer is formed on the carrier layer.

[0052] Example 2: The difference between this example and Example 1 is that: (2) a carrier is prepared, and the preparation method thereof is as follows:

[0053] Calculate the components by mass percentage: 41% oil, 21% hydrogel, 13% fatty alcohol, 4% emulsifier, 12% thermosensitive hydroxypropyl methylcellulose and 9% water.

[0054] Heat and melt the oil, mix the hydrogel with water, add the fatty alcohol after the two are mixed, add the emulsifier while stirring at a stirring speed of 280r / min, then add the thermosensitive hydroxypropyl methylcellulose, continue stirring at a stirring speed of 280r / min for 20min, and then transfer to a high-speed homogenizer for homogenization. The speed of the high-speed homogenizer is 6000r / min, the temperature is 30°C, and the processing time is 1.2h. Then, take it out and place it in a container, and cool it naturally to room temperature to obtain the carrier.

[0055] Example 3: The difference between this example and Example 1 is that: (2) a carrier is prepared, and the preparation method thereof is as follows:

[0056] Calculate the components by mass percentage: 41% oil, 21% hydrogel, 14% fatty alcohol, 4% emulsifier, 13% thermosensitive hydroxypropyl methylcellulose and 7% water.

[0057] Heat and melt the oil, mix the hydrogel with water, add the fatty alcohol after the two are mixed, add the emulsifier while stirring at a stirring speed of 280r / min, then add the thermosensitive hydroxypropyl methylcellulose, continue stirring at a stirring speed of 280r / min for 20min, and transfer to a high-speed homogenizer for homogenization. The speed of the high-speed homogenizer is 5000r / min, the temperature is 30°C, and the processing time is 1.5h. Then, take it out and place it in a container, and cool it naturally to room temperature to obtain the carrier.

[0058] Example 4: The difference between this example and Example 1 is that: (3) preparing honeysuckle-gardenia-purslane steam extract, the preparation method is as follows:

[0059] A1. Weigh honeysuckle, gardenia and purslane in a mass ratio of 1:1.1:1.4, mix to obtain a raw material, add 70°C water of 4 times their weight, soak for 1 hour, and obtain an soaked material.

[0060] A2. Add 7 times the total weight of water to the soaked material obtained in A1, and distill and reflux for 11 hours to obtain a feed solution.

[0061] A3. Concentrate the liquid obtained in A2 to 3 times the total weight of the raw materials, let it stand for 11 hours to precipitate, take the supernatant and concentrate it under reduced pressure to a relative density of 1.17 at 60°C, spray dry, collect powder, and grind to obtain the honeysuckle-gardenia-purslane steam extract.

[0062] Example 5: The difference between this example and Example 1 is that: (3) preparing honeysuckle-gardenia-purslane steam extract, the preparation method is as follows:

[0063] A1. Weigh honeysuckle, gardenia and purslane in a mass ratio of 1:1.2:1.5, mix to obtain a raw material, add 65°C water 3.5 times their weight, soak for 1 hour, and obtain an soaked material.

[0064] A2. Add 8 times the total weight of water to the soaked material obtained in A1, and distill and reflux for 12 hours to obtain a feed solution.

[0065] A3. Concentrate the liquid obtained in A2 to 3 times the total weight of the raw materials, let it stand for 12 hours to precipitate, take the supernatant and concentrate it under reduced pressure to a relative density of 1.17 at 60°C, spray dry, collect powder, and grind to obtain the honeysuckle-gardenia-purslane steam extract.

[0066] Example 6: The difference between this example and Example 1 is that: (4) a paste body is prepared, and the preparation method thereof is as follows:

[0067] The components were weighed in parts by weight: 5 parts of Artocarpus nanchuanensis, 4 parts of Scutellaria baicalensis, 2 parts of Phellodendron amurense, 0.3 parts of honeysuckle-gardenia-portulaca steam extract, 2 parts of Forsythia suspensa, 0.7 parts of Sophora flavescens, 0.5 parts of Dictamni cortex, 0.5 parts of Kochia scoparia and 5 parts of Artemisia argyi oil.

[0068] Crush Artocarpus nanchuanensis, Scutellaria baicalensis, Phellodendron amurense, Forsythia suspensa, Sophora flavescens, Dictamni cortex and Kochia scoparia to obtain a mixed fine material; mix the mixed fine material with the honeysuckle-gardenia-portulaca water vapor extract, stir at a stirring speed of 200 r / min for 30 minutes until the mixture is uniform, add wormwood oil, and continue stirring at a stirring speed of 300 r / min for 30 minutes to mix well, to obtain the paste body.

[0069] Example 7: The difference between this example and Example 1 is that: (4) a paste body is prepared, and the preparation method thereof is as follows:

[0070] The components were weighed in parts by weight: 7 parts of Artocarpus nanchuanensis, 5 parts of Scutellaria baicalensis, 3 parts of Phellodendron amurense, 0.5 parts of honeysuckle-gardenia-portulaca steam extract, 3 parts of Forsythia suspensa, 0.9 parts of Sophora flavescens, 0.8 parts of Dictamni cortex, 0.8 parts of Kochia scoparia and 6 parts of Artemisia argyi oil.

[0071] Crush Artocarpus nanchuanensis, Scutellaria baicalensis, Phellodendron amurense, Forsythia suspensa, Sophora flavescens, Dictamni cortex and Kochia scoparia to obtain a mixed fine material; mix the mixed fine material with the honeysuckle-gardenia-portulaca water vapor extract, stir at a stirring speed of 200 r / min for 30 minutes until the mixture is uniform, add wormwood oil, and continue stirring at a stirring speed of 300 r / min for 30 minutes to mix well, to obtain the paste body.

[0072] Comparative Example 1: The difference between this comparative example and Example 1 is that in the preparation of the carrier, the thermosensitive hydroxypropyl methylcellulose is replaced by hydroxypropyl methylcellulose.

[0073] Specifically, the carrier is prepared, and the preparation method thereof is as follows:

[0074] Calculate the components by mass percentage: 42% oil, 22% hydrogel, 13.5% fatty alcohol, 4.5% emulsifier, 12.5% ​​hydroxypropyl methylcellulose and 5.5% water.

[0075] Heat and melt the oil, mix the hydrogel with water, add the fatty alcohol after the two are mixed, add the emulsifier while stirring at a stirring speed of 280r / min, then add hydroxypropyl methylcellulose, continue stirring at a stirring speed of 280r / min for 20min, and transfer to a high-speed homogenizer for homogenization. The speed of the high-speed homogenizer is 5500r / min, the temperature is 30°C, and the processing time is 1.2h. Then, take it out and place it in a container, and cool it naturally to room temperature to obtain the carrier.

[0076] Comparative Example 2: The difference between this comparative example and Example 1 is that in the preparation of the carrier, the heat-sensitive hydroxypropyl methylcellulose is deleted.

[0077] Specifically, the carrier is prepared, and the preparation method thereof is as follows:

[0078] Calculate the components by mass percentage: 48% oil, 25.1% hydrogel, 15.4% fatty alcohol, 5.1% emulsifier and 6.4% water.

[0079] Heat the oil to melt, mix the hydrogel with water, add the fatty alcohol after the two are mixed, add the emulsifier while stirring at a stirring speed of 280r / min, continue stirring at a stirring speed of 280r / min for 20min, and transfer to a high-speed homogenizer for homogenization. The speed of the high-speed homogenizer is 5500r / min, the temperature is 30°C, and the processing time is 1.2h. Then, take it out and place it in a container, and cool it naturally to room temperature to obtain the carrier.

[0080] Comparative Example 3: The difference between this comparative example and Example 1 is that the carrier is replaced by white vaseline.

[0081] Specifically, the application of the anti-allergic cream has the following specific steps: first, apply white vaseline evenly to the affected area and the surrounding area. The amount is calculated based on the skin area, which is about 0.3g / cm 2 , rotate clockwise and press for 3 minutes to form a carrier layer on the skin. Then, apply the cream evenly on the carrier layer. The amount is calculated based on the skin area, about 0.6g / cm 2 That is, the amount of the ointment body is about twice that of white vaseline. After pressing counterclockwise for 1 minute, an ointment layer is formed on the carrier layer.

[0082] Comparative Example 4: The difference between this comparative example and Example 1 is that the carrier is deleted.

[0083] Specifically, the application of the anti-allergic cream, the specific use steps are: apply the cream evenly to the affected area and the surrounding area of ​​the skin, the dosage is calculated based on the skin area, about 0.6g / cm 2 , rotate counterclockwise and press for 1 minute to form an ointment layer.

[0084] Comparative Example 5: The difference between this comparative example and Example 1 is that in the preparation of the paste body, the honeysuckle-gardenia-purslane steam extract is replaced by a mixture of honeysuckle steam extract, gardenia steam extract and purslane steam extract. The specific steam extraction method / process remains unchanged. That is, the three are not mixed together for steam extraction, but are steam extracted separately and then physically mixed.

[0085] Specifically, the paste body is prepared, and the preparation method thereof is as follows:

[0086] The components were weighed in parts by weight: 6 parts of Artocarpus nanchuanensis, 4.5 parts of Scutellaria baicalensis, 2.5 parts of Phellodendron amurense, 0.13 parts of honeysuckle steam extract, 0.13 parts of Gardenia jasminoides steam extract, 0.13 parts of Portulaca oleracea steam extract, 2.5 parts of Forsythia suspensa, 0.8 parts of Sophora flavescens, 0.7 parts of Dictamni cortex, 0.6 parts of Kochia scoparia and 5.5 parts of Artemisia argyi oil.

[0087] Crush Artocarpus nanchuanensis, Scutellaria baicalensis, Phellodendron chinense, Forsythia suspensa, Sophora flavescens, Dictamni cortex and Kochia scoparia to obtain a mixed fine material; mix the mixed fine material with honeysuckle steam extract, gardenia steam extract and purslane steam extract, stir at a stirring speed of 200 r / min for 30 minutes until the mixture is uniform, add wormwood oil, and continue stirring at a stirring speed of 300 r / min for 30 minutes to mix well, to obtain the paste body.

[0088] Comparative Example 6: The difference between this comparative example and Example 1 is that in the preparation of the paste body, the honeysuckle-gardenia-purslane steam extract is deleted.

[0089] Specifically, the paste body is prepared, and the preparation method thereof is as follows:

[0090] The components were weighed in parts by weight: 6 parts of Artocarpus nanchuanensis, 4.5 parts of Scutellaria baicalensis, 2.5 parts of Phellodendron amurense, 2.5 parts of Forsythia suspensa, 0.8 parts of Sophora flavescens, 0.7 parts of Dictamni cortex, 0.6 parts of Kochia scoparia and 5.5 parts of Artemisia argyi oil.

[0091] Crush Artocarpus nanchuanensis, Scutellaria baicalensis, Phellodendron chinense, Forsythia suspensa, Sophora flavescens, Dictamni cortex and Kochia scoparia to obtain a mixed fine material; stir at a stirring speed of 200 r / min for 30 minutes until the mixture is uniformly mixed, add Artemisia argyi oil, and continue stirring at a stirring speed of 300 r / min for 30 minutes to mix uniformly, thereby obtaining the paste body.

[0092] Comparative Example 7: The difference between this comparative example and Example 1 is that: in the preparation of the carrier, the heat-sensitive hydroxypropyl methylcellulose is deleted; and in the preparation of the paste body, the honeysuckle-gardenia-purslane steam extract is deleted.

[0093] Test Example 1: Test item: Effect on local skin allergy / itching in mice.

[0094] Test objects: products obtained from Examples 1-7 and Comparative Examples 1-7.

[0095] Test method: 90 mice, half male and half female, were randomly divided into 15 groups, namely, a blank control group (applied with distilled water), Example 1-7 groups (applied with Example 1-7 anti-allergic cream) and Comparative Example 1-7 groups (applied with Comparative Example 1-7 anti-allergic cream). The back skin of each mouse was depilated for about 4 cm 2 Then use coarse sandpaper to scratch the shaved area by 1cm 2 , apply the corresponding substances on the depilatory area, and after 10 minutes, begin to drip 0.01% histamine phosphate solution on the abrasion surface at 0.05 ml / mouse, and then increase the concentration by 0.02%, 0.03%, and 0.04% every 3 minutes, each time at 0.05 ml / mouse, until the mouse turns back to lick, stop dripping histamine phosphate solution, and use the total amount of histamine phosphate dripped as the itch value, record and calculate the average of each group. The larger the average itch value, the better the anti-allergic / itch-relieving effect of the applied substance.

[0096] Test results: See Table 1.

[0097] Table 1. Test data of test example 1

[0098] Group Average itch value (μg) Blank control group 57.37 Example 1 169.51 Example 2 166.12 Example 3 170.57 Example 4 167.28 Example 5 169.17 Example 6 171.55 Example 7 166.92 Comparative Example 1 152.17 Comparative Example 2 145.43 Comparative Example 3 129.08 Comparative Example 4 134.32 Comparative Example 5 154.28 Comparative Example 6 148.74 Comparative Example 7 131.91

[0099] Result analysis: Analyze the blank control group and Examples 1-7 and combine the data in Table 1 and Figure 1 It can be seen that the effective ingredients of the anti-allergic paste of the present invention are all Chinese medicine components, without side effects, and the use effect can increase the itching value from 57.37 μg of the blank control group to more than 166.92 μg, and the anti-allergic / antipruritic effect is significant.

[0100] Analyze Comparative Examples 3 and 4 and combine the data in Table 1 and Figure 1 It can be seen that the itch value measured in Comparative Example 4 (direct application of the cream of the present invention) is 134.32 μg, while the itch value measured in Comparative Example 3 (application of the cream of the present invention after application of white vaseline as a carrier) is 129.08 μg, that is, the application of white vaseline as a carrier alone will cause the anti-allergic / antipruritic effect of the cream of the present invention to decrease instead of increase.

[0101] Analyze Example 1, Comparative Example 1, Comparative Example 2 and Comparative Example 4 and combine the data in Table 1 and Figure 1 It can be seen that when the carrier and the paste body are used together, the addition of hydroxypropyl methylcellulose in the preparation of the carrier of the present invention can improve the anti-allergic / antipruritic effect of the paste body of the present invention, that is, improve the anti-allergic / antipruritic effect of the anti-allergic paste of the present invention; preparing hydroxypropyl methylcellulose into the thermosensitive hydroxypropyl methylcellulose of the present invention and then adding it can further improve the anti-allergic / antipruritic effect of the paste body of the present invention, that is, further improve the anti-allergic / antipruritic effect of the anti-allergic paste of the present invention.

[0102] Analyze Example 1 and Comparative Examples 5-6 and combine the data in Table 1 and Figure 1 It can be seen that in the preparation of the paste body of the present invention, the addition of honeysuckle water vapor extract, gardenia water vapor extract and purslane water vapor extract can improve the anti-allergic / antipruritic effect of the paste body of the present invention, that is, improve the anti-allergic / antipruritic effect of the anti-allergic paste of the present invention; steam extraction of honeysuckle, gardenia and purslane together to obtain honeysuckle-gardenia-purslane water vapor extract and then adding it can further improve the anti-allergic / antipruritic effect of the paste body of the present invention, that is, further improve the anti-allergic / antipruritic effect of the anti-allergic paste of the present invention.

[0103] Analyze Example 1, Comparative Example 2, Comparative Example 6 and Comparative Example 7 and combine the data in Table 1 and Figure 1 It can be seen that the addition of heat-sensitive hydroxypropyl methylcellulose in the preparation of the carrier of the present invention and the addition of honeysuckle-gardenia-portulaca water vapor extract in the preparation of the paste body of the present invention have a synergistic effect, which can synergistically improve the anti-allergic / antipruritic effect of the anti-allergic paste of the present invention.

[0104] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. In order to avoid unnecessary repetition, the present invention will not further describe various possible combinations.

[0105] In addition, various embodiments of the present invention may be arbitrarily combined, and as long as they do not violate the concept of the present invention, they should also be regarded as the contents disclosed by the present invention.

Claims

1. An anti-allergic paste, characterized in that: It includes a carrier and a paste body; The carrier comprises the following components by mass percentage: 41-44% of oil, 21-23% of hydrogel, 13-14% of fatty alcohol, 4-5% of emulsifier, 12-13% of thermosensitive hydroxypropyl methylcellulose and the balance of water; The paste body comprises the following components by weight: 5-7 parts of Nanchuan woodbine, 4-5 parts of scutellaria baicalensis, 2-3 parts of phellodendron amurense, 0.3-0.5 parts of honeysuckle-gardenia-portulaca water vapor extract, 2-3 parts of forsythia, 0.7-0.9 parts of sophora flavescens, 0.5-0.8 parts of difficile cortex, 0.5-0.8 parts of kochia scoparia and 5-6 parts of wormwood oil.

2. The antiallergic paste according to claim 1, characterized in that: The preparation method of the thermosensitive hydroxypropyl methylcellulose is as follows: A1. Mix equal amounts of a 7-9% hydroxypropyl methylcellulose aqueous solution and a 7-9% poly (N-isopropylacrylamide) aqueous solution to obtain a mixed solution; A2, treat the mixture obtained in A1 in a fume hood at 60-70°C until a viscous gel-like substance is formed; A3. Transfer the gel-like substance obtained in A2 to an oven, dry it at 85-90°C for 3-5 hours, take it out, grind it into powder, and obtain thermosensitive hydroxypropyl methylcellulose.

3. The antiallergic paste according to claim 1, characterized in that: The oil comprises one of white vaseline, liquid paraffin and lanolin or a mixture of at least two of them.

4. The antiallergic paste according to claim 1, characterized in that: The hydrogel is carbomer.

5. The antiallergic paste according to claim 1, characterized in that: The fatty alcohol includes stearyl alcohol or cetyl alcohol.

6. The antiallergic paste according to claim 1, characterized in that: The emulsifier includes polysorbate or Span.

7. The antiallergic paste according to claim 1, characterized in that: The preparation method of the honeysuckle-gardenia-purslane water vapor extract is as follows: A1. Weigh honeysuckle, gardenia and purslane in a mass ratio of 1: (1-1.2): (1.3-1.5), mix to obtain raw materials, add 65-70° C. water in an amount of 3-4 times the total weight of the raw materials, soak for 1-2 hours, and obtain an soaked material; A2, add 7-8 times the total weight of water to the soaked material obtained in A1, and distill and reflux for 10-12 hours to obtain a liquid; A3. Concentrate the liquid obtained in A2 to 3-3.5 times the total weight of the raw materials, let it stand for 8-12 hours to precipitate, take the supernatant and concentrate it under reduced pressure to a relative density of 1.17 at 60°C, spray dry, collect powder, and grind to obtain the honeysuckle-gardenia-purslane steam extract.

8. A method for preparing the antiallergic paste according to any one of claims 1 to 7, characterized in that: The steps include: S1. preparing a carrier; Heat and melt the oil, mix the hydrogel and water, add fatty alcohol after the two are mixed, add emulsifier while stirring continuously, then add heat-sensitive hydroxypropyl methylcellulose, transfer to a high-speed homogenizer for homogenization, and naturally cool to room temperature to obtain a carrier; S2, preparing the paste body; Crush Nanchuan Phellodendron, Scutellaria baicalensis, Phellodendron amurense, Forsythia suspensa, Sophora flavescens, Dictamni cortex and Kochia scoparia to obtain a mixed fine material; evenly mix the mixed fine material with honeysuckle-gardenia-purslane steam extract, add wormwood oil, and continue stirring to mix well to obtain the paste body.

9. The method for preparing the antiallergic paste according to claim 8, characterized in that: In S1, the speed of the high-speed homogenizer is 5000-6000 r / min, the temperature is 28-30°C, and the processing time is 1-1.5 h.

10. Use of the antiallergic paste according to any one of claims 1 to 7, characterized in that: First apply the carrier to the affected area and surrounding areas of the skin, rotate and press clockwise for 3-5 minutes to form a carrier layer, and then apply the ointment body on the carrier layer.

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