Traditional Chinese medicine composition for treating parotitis, oral inflammation and laryngitis

Abstract

The invention relates to a traditional Chinese medicine composition for treating parotitis, oral inflammation and laryngitis. The traditional Chinese medicine composition is prepared from 60-85 g of radix et rhizoma rhei, 60-85 g of radix scutellariae, 10-40 g of flos lonicerae, 10-40 g of fructus forsythiae, 10-30 g of agilawood, 10-20 g of chlorite schist aureum and 1-4 g of cinnabar. The traditional Chinese medicine composition adopts traditional Chinese medicines with small or no toxic and side effects, the medication is simple (few and fine medicines are adopted), the compatibility is proper, clinical practice tests for many years prove that the traditional Chinese medicine composition can effectively improve clinical symptoms of children suffering from parotitis, oral inflammation and laryngitis, the total effective rate reaches 90% or above, and the treatment effect is good.

Description

Technical Field

[0001] The invention relates to the field of medicine, and more specifically to a Chinese medicine composition for treating parotitis, stomatitis and laryngitis in children. Background Art

[0002] Mumps is a common infectious disease in children. It is caused by the mumps virus and is often manifested by headache, non-suppurative swelling of the parotid or other salivary glands, and fever. In addition to invading the parotid gland, it can also cause meningitis. Currently, the treatment of mumps is mainly symptomatic treatment + traditional Chinese medicine treatment. Traditional Chinese medicine treatment mainly involves oral traditional Chinese medicine preparations that clear away heat, detoxify, soften hard masses, and relieve pain.

[0003] Pediatric stomatitis refers to inflammation of the oral mucosa of children due to various infections. It can occur alone or be secondary to the whole body. Infections are often caused by viruses, fungi, and bacteria, including exanthematous stomatitis, thrush, bacterial stomatitis, hand, foot and mouth disease, etc. The main clinical symptoms are: oral mucosal congestion, edema, ulcers, small herpes, and pain. Different treatment methods are used for stomatitis caused by different causes, but Chinese medicine treatment for the above-mentioned pediatric stomatitis mainly focuses on clearing heat, detoxifying, and reducing inflammation.

[0004] Pharyngitis in children is also a common disease in children. It is a disease in which inflammation of the throat occurs. Typical symptoms include fever, nausea and vomiting, sore throat, hoarseness, cough with sputum, and difficulty breathing. At present, the treatment of pharyngitis in children is mainly through systemic + local medication to alleviate systemic symptoms, relieve inflammation of the throat mucosa, and improve breathing, swallowing, and voice function; among them, systemic use mainly involves the combined use of antibiotics, antiviral drugs, and mucosal excretion-promoting drugs. For the choice of antiviral drugs, Chinese medicine is usually used for treatment, and Western medicines such as acyclovir and ribavirin can also be used.

[0005] Xiaoer Huadu Powder originated from Saijin Huadu Powder in the Ming Dynasty's "Jinjinglu of Diaozhen", and is now included in the "Pharmacopoeia of the People's Republic of China" (2015 edition). Its drug composition is: artificial bezoar, pearl, realgar, rhubarb, coptis, licorice, radix trichosanthis, Fritillaria cirrhosa, red peony root, frankincense (processed), myrrh (processed), borneol, licorice, which has the effects of clearing heat and detoxifying, promoting blood circulation and reducing swelling. It is suitable for oral sores, ulcers, irritability, thirst, and constipation caused by internal heat and toxicity, and toxic evil. It is often used clinically to treat acute tonsillitis, mumps, erysipelas, ulcerative stomatitis, angular cheilitis, hand, foot and mouth disease, etc., and can effectively improve the clinical symptoms of children; but the realgar in this prescription is an arsenic compound, which has mutagenic and carcinogenic effects. It has been proven that it can cause skin cancer, bronchial cancer, liver cancer, and can induce oral, esophageal, laryngeal and bladder cancer. It is highly toxic, so it is necessary to improve this prescription. Summary of the invention

[0006] The purpose of the present invention is to provide a Chinese medicine composition for treating mumps, stomatitis and laryngitis in children. The Chinese medicine composition adopts Chinese medicine with little or no toxic side effects, simple medication (few but fine medicinal flavors), proper compatibility, and has been proved through many years of clinical practice that the Chinese medicine composition can effectively improve the clinical symptoms of children suffering from mumps, stomatitis and laryngitis, and has a good therapeutic effect.

[0007] To achieve the above object, the present invention adopts the following technical solutions:

[0008] A traditional Chinese medicine composition for treating parotitis, stomatitis and laryngitis in children, the traditional Chinese medicine composition consists of 60-85g of rhubarb, 60-85g of scutellaria, 10-40g of honeysuckle, 10-40g of forsythia, 10-30g of agarwood, 10-20g of golden stone and 1-4g of cinnabar.

[0009] As a preferred embodiment of the present invention, the Chinese medicine composition is composed of 75g of rhubarb, 75g of scutellaria, 25g of honeysuckle, 25g of forsythia, 20g of agarwood, 15g of golden stone, and 2.5g of cinnabar.

[0010] The Chinese medicine composition provided by the present invention has been proved through clinical trials that it has good therapeutic effects on children with mumps, stomatitis and acute laryngitis, and the total effective rate is more than 90%. Therefore, the Chinese medicine composition can be used in the preparation of medicines for treating mumps, stomatitis and laryngitis.

[0011] The dosage form of the medicine for treating mumps, stomatitis and laryngitis of the present invention is an oral preparation or an external preparation; wherein the oral preparation is selected from any one of powders, granules, tablets, capsules, oral liquids or pills.

[0012] The present invention also provides a Chinese medicine powder for treating parotitis, stomatitis and laryngitis in children, wherein the Chinese medicine powder is composed of the following raw materials by weight: 60-85g of rhubarb, 60-85g of scutellaria, 10-40g of honeysuckle, 10-40g of forsythia, 10-30g of agarwood, 10-20g of gold stone and 1-4g of cinnabar;

[0013] The preparation method of the Chinese medicine powder comprises the following steps:

[0014] Step 1. Mix rhubarb, scutellaria, honeysuckle, forsythia, agarwood, and golden stone, grind into fine powder, and sieve;

[0015] Step 2. Grind the cinnabar into fine powder, mix it evenly with the medicinal powder prepared in step 1, and divide it into packages.

[0016] Advantages and beneficial effects of the present invention:

[0017] (1) The Chinese medicine composition provided by the present invention has simple medication and proper compatibility. The rhubarb in the prescription is bitter and cold in nature and enters the spleen, stomach, large intestine, liver and pericardium meridians, and has the functions of clearing away heat and purging fire, cooling blood and detoxifying; the scutellaria baicalensis is bitter and cold in nature and enters the lung, gallbladder, spleen, large intestine and small intestine meridians, and has the functions of clearing heat and dampness, purging fire and detoxifying, cooling blood and stopping bleeding; in addition, it also has antibacterial and antiviral effects, and has a certain inhibitory effect on various pathogenic bacteria and viruses; the forsythia is slightly cold in nature and bitter in taste and enters the lung, heart and small intestine meridians, and has the functions of clearing heat and detoxifying, reducing swelling and dispersing nodules, and evacuating wind-heat, and also has the functions of antibacterial and anti-inflammatory; the honeysuckle is sweet and cold in nature and enters the lung, heart and stomach meridians; it has the functions of evacuating wind-heat, clearing heat and detoxifying It has a certain inhibitory effect on many pathogenic bacteria and viruses; Rhubarb and Scutellaria both have the effect of purging fire and detoxifying. When used with Forsythia suspensa and Honeysuckle, they can more comprehensively clear the fire and heat toxins in the body and relieve various symptoms caused by heat toxins; Forsythia suspensa and Honeysuckle both have the effect of reducing swelling and dispersing nodules. Their combination can enhance this effect and is used to treat various carbuncles, sores and other diseases; Agarwood is pungent and bitter in taste, slightly warm in nature, warms the middle and promotes qi circulation, can neutralize the bitter and cold nature of the above four medicines, and also has the effect of antibacterial, anti-inflammatory and analgesic; Jinlunshi is a heavy sedative and calms the mind, cinnabar clears away heat and detoxifies, calms the mind and calms the nerves. When used with the above medicines, it can quickly relieve the symptoms of intense heat and toxins, and effectively prevent heat shock.

[0018] (2) The Chinese medicine composition provided by the present invention uses Chinese medicine with little or no toxic side effects. The prescription has been proven through many years of clinical practice to be effective in improving the clinical symptoms of children suffering from mumps, stomatitis, and laryngitis, with a total effective rate of more than 90%. The therapeutic effect is good, and the therapeutic effect for acute laryngitis is significantly better than that of Xiaoer Huadu San. DETAILED DESCRIPTION

[0019] The present invention discloses a Chinese medicine composition for treating mumps, stomatitis and laryngitis. Those skilled in the art can refer to the contents of this article and appropriately improve the component parameters or process parameters to achieve the above. It should be particularly noted that all similar substitutions and modifications are obvious to those skilled in the art and are deemed to be included in the scope of protection of the present invention.

[0020] Example 1

[0021] The present embodiment provides a traditional Chinese medicine composition for treating mumps, stomatitis and laryngitis in children, wherein the traditional Chinese medicine composition is composed of 75g of rhubarb, 75g of scutellaria, 25g of honeysuckle, 25g of forsythia, 20g of agarwood, 15g of golden stone and 2.5g of cinnabar.

[0022] The composition provided in this embodiment can be made into an oral preparation when actually used; of course, it can also be made into an external preparation as needed; wherein, the oral preparation includes powders, granules, tablets, capsules, oral liquids or pills, etc. Among the above dosage forms, powders have the advantages of being simple and easy to prepare and can be taken orally or externally, so powders are preferred.

[0023] Specifically, the preparation method of the powder comprises the following steps:

[0024] Step 1. Mix rhubarb, scutellaria, honeysuckle, forsythia, agarwood, and golden stone, grind into fine powder, and sieve;

[0025] Step 2. Grind the cinnabar into fine powder, mix it evenly with the medicinal powder prepared in step 1, and divide it into packages.

[0026] It should be noted that the Chinese medicine powder provided in this embodiment can be appropriately added or subtracted according to the severity of the child's symptoms and the length of the course of the disease when clinically used; for example, the dosage of gold and silver stone and cinnabar can be appropriately increased for children with high fever, and the dosage of scutellaria baicalensis can be appropriately increased for children with a long course of disease; of course, the dosage of each raw material of the above-mentioned Chinese medicine powder needs to be controlled within the following range no matter how it is added or subtracted:

[0027] Rhubarb 60-85g, Scutellaria baicalensis 60-85g, Honeysuckle 10-40g, Forsythia suspensa 10-40g, Agarwood 10-30g, Chrysanthemum stone 10-20g, Cinnabar 1-4g.

[0028] The rhubarb in the Chinese medicine composition provided by the present invention has the functions of clearing away heat, purging fire, cooling blood and detoxifying; the scutellaria has the functions of clearing heat and drying dampness, purging fire and detoxifying, cooling blood and stopping bleeding; in addition, it also has antibacterial and antiviral effects, and has a certain inhibitory effect on various pathogenic bacteria and viruses; the forsythia has the effects of clearing heat and detoxifying, reducing swelling and dispersing knots, and evacuating wind-heat, and also has the effects of antibacterial and anti-inflammatory; the honeysuckle has the effects of evacuating wind-heat, clearing heat and detoxifying, and has a certain inhibitory effect on various pathogenic bacteria and viruses; both rhubarb and scutellaria have the functions of purging fire and detoxifying, and after being matched with forsythia and honeysuckle, they can more comprehensively eliminate the fire and heat poison in the body and relieve Various symptoms caused by heat toxins; Forsythia suspensa and honeysuckle both have the effect of reducing swelling and dispersing nodules, and their combination can enhance this effect and is used to treat various carbuncle, sore and other diseases; Agarwood can neutralize the bitter and cold nature of the above four herbs, and at the same time has the effect of antibacterial, anti-inflammatory and analgesic; Jinlunshi is a heavy tranquilizer, while cinnabar clears away heat and detoxifies, calms the nerves and calms the nerves. When used in combination with the above drugs, it can quickly relieve the symptoms of intense heat toxins and effectively prevent heat shock. This prescription has been used in Jilin Children's Hospital for many years and is effective for children with mumps, stomatitis and laryngitis. The following clinical data will illustrate the therapeutic effect of the Chinese medicine composition of the present invention, as follows:

[0029] 1. The clinical efficacy of treating mumps is as follows:

[0030] 1. Clinical data

[0031] A total of 48 children with mumps who visited the outpatient department of Jilin Children's Hospital from August 2021 to June 2023 (meeting the diagnostic criteria for mumps, age <12 years old) were selected as research subjects. They were randomly divided into a control group and a study group, with 24 cases in each group. There were 16 males and 8 females in the control group, aged 4 to 10 years old, with a course of 1 to 5 days; there were 14 males and 10 females in the study group, aged 5 to 11 years old, with a course of 1 to 5 days; there was no statistically significant difference in the general data between the two groups, and they were comparable.

[0032] 2. Treatment Methods

[0033] After admission, both groups were supplemented with conventional treatment, and physical and drug cooling was adopted for those with high fever; antibacterial drugs were given to those with combined infection. On this basis, the control group was treated with Xiaoer Huadu Powder (Guangxi Nanzhu Pharmaceutical Co., Ltd., National Medicine Standard Z45021270, specification: 0.6g×9 bags / box); oral, 0.6g once, twice a day, for 5 consecutive days. The study group was treated with the Chinese medicine powder of Example 1, orally, 4 to 6 years old, 2g once, twice a day; 7 to 10 years old, 3.5g once, twice a day; over 10 years old, 5g once, twice a day; continuous medication for 5 days.

[0034] 3. Observation indicators

[0035] Markedly effective: After 3 days of medication, the child's body temperature returned to normal, and symptoms such as parotid swelling and pain completely disappeared;

[0036] Effective: After 3 days of medication, the child's body temperature returned to normal, and symptoms such as parotid swelling and pain improved;

[0037] Invalid: Failed to meet the above criteria;

[0038] Total effective rate = (markedly effective + effective) / total number of cases × 100%.

[0039] 4. Treatment Outcomes

[0040] The total effective rate of the study group was 91.7%, and the total effective rate of the control group was 83.3%. The study group was higher than the control group, as shown in Table 1.

[0041] Table 1 shows the treatment of children with mumps using the Chinese medicine powder of Example 1 and the control sample (Xiaoer Huadu Powder)

[0042] Group Number of cases Significant effect efficient invalid Total Effectiveness Control group 24 12 8 4 83.3％ Research Group 24 14 8 2 91.7％

[0043] 2. The clinical efficacy of treating hand, foot and mouth disease is as follows:

[0044] 1. Clinical data

[0045] A total of 84 children with hand, foot and mouth disease (meeting the diagnostic criteria for hand, foot and mouth disease in children, aged <8 years old) who visited the outpatient department of Jilin Children's Hospital from June 2022 to October 2023 were selected as the research subjects. They were randomly divided into a control group and a study group, with 42 cases in each group; the control group had 28 males and 14 females; aged 6 months to 7 years old, body temperature 37.6-40.2℃, 34 common cases, and 8 severe cases; the study group had 26 males and 16 females; aged 5 months to 7 years old, body temperature 37.5-40.3℃, 35 common cases, and 7 severe cases; there was no significant difference in the general data between the two groups, and they were comparable.

[0046] 2. Treatment Methods

[0047] Control group - antibiotic treatment: 50 mg / kg ceftazidime for injection (Qilu Pharmaceutical Co., Ltd.) was added to 100 mL of 0.9% sodium chloride injection and intravenously dripped twice a day for 7 consecutive days; antiviral drug treatment: Xiaoer Huadu Powder (Guangxi Nanzhu Pharmaceutical Co., Ltd., national medicine standard Z45021270, specification: 0.6 g × 9 bags / box) was given for treatment, oral + external use, oral, under 1 year old, 0.15 g once, twice a day; 1 to 3 years old, 0.3 g once, twice a day; 3 to 7 years old, 0.6 g once, twice a day, for 7 consecutive days; external use: dip a cotton swab in an appropriate amount of Xiaoer Huadu Powder and apply it to the affected area of ​​the mouth, once in the morning and once in the evening, for 7 consecutive days.

[0048] Study group: antibiotic treatment is the same as the control group; antiviral drug treatment: oral + external use of the Chinese medicine powder of Example 1; oral, within 1 year old, 0.5g once, twice a day; 2 to 3 years old, 1g once, twice a day; 4 to 6 years old, 2g once, twice a day; 7 years old, 3.5g once, twice a day, for 7 consecutive days. For external use, dip a cotton swab in an appropriate amount and apply it to the affected part of the mouth, once in the morning and evening, for 7 consecutive days.

[0049] 3. Observation indicators

[0050] Recovery: body temperature returns to normal within 1 day, oral pain improves, and rash completely disappears;

[0051] Markedly effective: Body temperature returns to normal in 1-2 days, oral pain is significantly relieved, and most of the rash disappears;

[0052] Effective: Body temperature returns to normal in 2-3 days, oral pain improves, and rash gradually subsides;

[0053] Ineffective: body temperature does not return to normal for ≥ 3 days, oral pain has no obvious change, and rash has no obvious change or even increases;

[0054] Total effective rate = (cured + markedly effective + effective) / total number of cases × 100%.

[0055] 4. Treatment Outcomes

[0056] The total effective rate of the study group was 92.9%, and the total effective rate of the control group was 90.5%. The treatment effects of the study group and the control group were basically the same, as shown in Table 2 for details.

[0057] Table 2 shows the treatment of children with hand, foot and mouth disease using the Chinese medicine powder of Example 1 and the control sample (Xiaoer Huadu Powder)

[0058] Group Number of cases get well Significant effect efficient invalid Total Effectiveness Control group 42 16 12 10 4 90.5％ Research Group 42 18 13 8 3 92.9％

[0059] 3. The clinical efficacy of treating acute laryngitis is as follows:

[0060] 1. Clinical data

[0061] A total of 108 children with acute laryngitis who visited the outpatient department of Jilin Children's Hospital from August 2022 to December 2023 (meeting the diagnostic criteria for acute laryngitis, course of disease <7 days; symptoms mainly cough, hoarseness, laryngeal chorus and dyspnea) were selected as the research subjects. They were randomly divided into a control group and a study group, with 54 cases in each group; the control group had 26 males and 28 females; aged 3-10 years old, course of disease 1-6 days, and laryngeal obstruction degrees Ⅰ, Ⅱ and Ⅲ in 36, 12 and 6 cases respectively; the study group had 28 males and 26 females; aged 3-10 years old, course of disease 1-6 days, and laryngeal obstruction degrees Ⅰ, Ⅱ and Ⅲ in 34, 13 and 7 cases respectively; there was no significant difference in general data between the two groups, and they were comparable.

[0062] 2. Treatment Methods

[0063] Both groups of children were given comprehensive treatments such as anti-infection, cough and expectoration, and inhalation of budesonide suspension (1 g / time, 2 times / d). On this basis, the control group took Xiaoer Huadu powder orally, 0.6 g once, twice a day, for 5 consecutive days; on this basis, the study group took the powder of Example 1 orally, 1 g once, twice a day for 2 to 3 years old; 2 g once, twice a day for 4 to 6 years old; 3.5 g once, twice a day for 7 years old, for 5 consecutive days.

[0064] 3. Observation indicators

[0065] Markedly effective: After treatment, the child's clinical symptoms such as cough, hoarseness, and larynx were significantly improved and breathing was smooth;

[0066] Effective: After treatment, the children's clinical symptoms such as cough, hoarseness, and laryngitis improved;

[0067] Ineffective: The above symptoms have not improved or have worsened;

[0068] Total effective rate = (markedly effective + effective) / total number of cases × 100%.

[0069] 4. Treatment Outcomes

[0070] The total effective rate of the study group was 100%, and the total effective rate of the control group was 87.0%. The study group was significantly higher than the control group, as shown in Table 3.

[0071] Table 3 shows the treatment of children with acute laryngitis using the Chinese medicine powder of Example 1 and the control sample (Xiaoer Huadu Powder)

[0072] Group Number of cases Significant effect efficient invalid Total Effectiveness Control group 54 21 26 7 87.0％ Research Group 54 38 16 0 <![CDATA[100% * ]]>

[0073] Compared with the control group: *P<0.05.

[0074] The above description is a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating mumps, stomatitis and laryngitis, characterized in that: The traditional Chinese medicine composition consists of 60-85g of rhubarb, 60-85g of scutellaria, 10-40g of honeysuckle, 10-40g of forsythia, 10-30g of agarwood, 10-20g of golden stone and 1-4g of cinnabar.

2. A Chinese medicine composition for treating mumps, stomatitis and laryngitis according to claim 1, characterized in that: The Chinese medicine composition consists of 75g of rhubarb, 75g of scutellaria, 25g of honeysuckle, 25g of forsythia, 20g of agarwood, 15g of golden stone and 2.5g of cinnabar.

3. Use of the Chinese medicine composition according to claim 1 or 2 in the preparation of medicines for treating mumps, stomatitis and laryngitis.

4. The use according to claim 3, characterized in that: The dosage form of the medicine for treating mumps, stomatitis and laryngitis is an oral preparation or an external preparation; wherein the oral preparation is selected from any one of powders, granules, tablets, capsules, oral liquids or pills.

5. A Chinese medicine powder for treating mumps, stomatitis and laryngitis, characterized in that: The Chinese medicine powder is composed of the following raw materials by weight: 60-85g of rhubarb, 60-85g of scutellaria, 10-40g of honeysuckle, 10-40g of forsythia, 10-30g of agarwood, 10-20g of gold agate, and 1-4g of cinnabar; The preparation method of the Chinese medicine powder comprises the following steps: Step 1. Mix rhubarb, scutellaria, honeysuckle, forsythia, agarwood, and golden stone, grind into fine powder, and sieve; Step 2. Grind the cinnabar into fine powder, mix it evenly with the medicinal powder prepared in step 1, and divide it into packages.